MCID: NCR002
MIFTS: 32

Necrobiosis Lipoidica malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Necrobiosis Lipoidica

Summaries for Necrobiosis Lipoidica

NIH Rare Diseases : 50 necrobiosis lipoidica is a rare skin disorder of collagen degeneration. it is characterized by a rash that occurs on the lower legs. it is more common in women, and there are usually several spots. they are slightly raised shiny red-brown patches. the centers are often yellowish and may develop open sores that are slow to heal. infections can occur but are uncommon. some patients have itching, pain, or abnormal sensations. it usually occurs more often in people with diabetes, in people with a family history of diabetes or a tendency to get diabetes, but can occur in nondiabetic people. about 11% to 65% of patients with necrobiosis lipoidica also have diabetes, but the exact cause is still not known. treatment is difficult. the disease is typically chronic with variable progression and scarring. last updated: 6/6/2016

MalaCards based summary : Necrobiosis Lipoidica is related to granuloma annulare and squamous cell carcinoma. An important gene associated with Necrobiosis Lipoidica is CD163 (CD163 Molecule), and among its related pathways/superpathways are Insulin resistance and HIF-1 signaling pathway. Affiliated tissues include skin, pancreas and neutrophil, and related phenotypes are cellular and vision/eye

Wikipedia : 71 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes... more...

Related Diseases for Necrobiosis Lipoidica

Diseases related to Necrobiosis Lipoidica via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
id Related Disease Score Top Affiliating Genes
1 granuloma annulare 10.7
2 squamous cell carcinoma 10.3
3 venous insufficiency 10.2
4 rheumatoid arthritis 10.0
5 arthritis 10.0
6 balanitis 10.0
7 angiokeratoma 10.0
8 thyroiditis 10.0
9 psoriasis 10.0
10 endotheliitis 10.0
11 hematologic cancer 9.9 GLI1 TNFRSF1B
12 obesity 9.9
13 ataxia-telangiectasia 9.9
14 common variable immunodeficiency 9.9
15 cutaneous leishmaniasis 9.9
16 lymphomatoid granulomatosis 9.9
17 maturity-onset diabetes of the young 9.9
18 dermatitis 9.9
19 histiocytosis 9.9
20 cellulitis 9.9
21 retinitis 9.9
22 syphilis 9.9
23 pyoderma 9.9
24 eye disease 9.9
25 retinal disease 9.9
26 tertiary syphilis 9.9
27 lupus erythematosus 9.9
28 leishmaniasis 9.9
29 necrobiotic xanthogranuloma 9.9
30 ataxia 9.9
31 discoid lupus erythematosus 9.9
32 brain stem glioma 9.8 INS SLC2A1
33 acinic cell breast carcinoma 9.8 SLC2A1 TNFRSF1B
34 signet ring cell adenocarcinoma 9.1 CD163 GLI1 INS RDH11 SLC2A1 TNFRSF1B

Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to Necrobiosis Lipoidica

Symptoms & Phenotypes for Necrobiosis Lipoidica

MGI Mouse Phenotypes related to Necrobiosis Lipoidica:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.35 INS SLC2A1 TNFRSF1B CD163 GLI1
2 vision/eye MP:0005391 8.92 CD163 INS RDH11 TNFRSF1B

Drugs & Therapeutics for Necrobiosis Lipoidica

Search Clinical Trials , NIH Clinical Center for Necrobiosis Lipoidica

Cochrane evidence based reviews: necrobiosis lipoidica

Genetic Tests for Necrobiosis Lipoidica

Anatomical Context for Necrobiosis Lipoidica

MalaCards organs/tissues related to Necrobiosis Lipoidica:

39
Skin, Pancreas, Neutrophil, Endothelial, Kidney, Thyroid, Tongue

Publications for Necrobiosis Lipoidica

Articles related to Necrobiosis Lipoidica:

(show top 50) (show all 391)
id Title Authors Year
1
Necrobiosis lipoidica developing within a surgical scar in a non-diabetic patient: Type III Koebner phenomenon (isomorphic response), Wolf's isotopic response or Ruocco's immunocompromised cutaneous district? ( 28071608 )
2017
2
Anti-TNFI+ treatment for recalcitrant ulcerative necrobiosis lipoidica diabeticorum: A case report and review of the literature. ( 26975548 )
2016
3
Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012. ( 26972191 )
2016
4
Necrobiosis Lipoidica. ( 27686584 )
2016
5
Sarcoidal Necrobiosis Lipoidica in a Nondiabetic Patient: Usefulness of Skin Ultrasound. ( 27001349 )
2016
6
Necrobiosis Lipoidica. ( 27771664 )
2016
7
Risk factors for necrobiosis lipoidica in Type 1 diabetes mellitus. ( 27101431 )
2016
8
Necrobiosis lipoidica der Peniseichel: ein Fallbericht mit LiteraturA1berblick. ( 27767276 )
2016
9
Kofaktoren und KomorbiditAoten bei Necrobiosis lipoidica - Analyse der deutschen DRG-Daten von 2012. ( 26972192 )
2016
10
Pediatric-onset necrobiosis lipoidica. ( 26865027 )
2016
11
Treatment of refractory ulcerative necrobiosis lipoidica diabeticorum with oral thalidomide. ( 26951036 )
2016
12
Necrobiosis lipoidica of the glans penis: a case report and literature review. ( 27767287 )
2016
13
Scald-Induced Necrobiosis Lipoidica in a Patient with Diabetes Mellitus and Psoriasis. ( 26889139 )
2016
14
Treatment Modalities of Necrobiosis Lipoidica: A Concise Systematic Review. ( 26236446 )
2015
15
Pentoxifylline: An effective therapy for necrobiosis lipoidica. ( 26559761 )
2015
16
Necrobiosis lipoidica diabeticorum. ( 26057508 )
2015
17
Granuloma annulare and necrobiosis lipoidica with sequential occurrence in a patient: report and review of literature. ( 25692078 )
2015
18
Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study. ( 26575980 )
2015
19
Necrobiosis Lipoidica: A Descriptive Study of 35 Cases. ( 25728565 )
2015
20
Necrobiosis lipoidica associated with Hashimoto's thyroiditis and positive detection of ANA and ASMA autoantibodies. ( 26273437 )
2015
21
Necrobiosis Lipoidica. ( 26143418 )
2015
22
Residents'corner February 2014. DeRmpath & Clinic: differential diagnosis in palisading non-infectious granulomas. Diagnosis: Case 1: Granuloma annulare. Case 2: Necrobiosis lipoidica. ( 24691245 )
2014
23
Selective case study describing the use of Apligraf on necrobiosis lipoidica associated with diabetes. ( 24600755 )
2014
24
Necrobiosis lipoidica occurring in a patient with rheumatoid arthritis on concurrent tumor necrosis factor-I+ inhibitor therapy. ( 24697547 )
2014
25
Ulcerated necrobiosis lipoidica to a teenager with diabetes mellitus and obesity. ( 24715184 )
2014
26
Palmoplantar pustulosis associated with necrobiosis lipoidica: a possible role of tumor necrosis factor-I+ and interleukin-17. ( 24628381 )
2014
27
Necrobiosis lipoidica-like cutaneous leishmaniasis. ( 25368717 )
2014
28
Necrobiosis lipoidica with elastophagocytosis on an unusual location. ( 24786578 )
2014
29
Necrobiosis Lipoidica Diabeticorum: A pediatric case report. ( 24575162 )
2014
30
Necrobiosis lipoidica with infiltration of Th17 cells into vascular lesions. ( 24801926 )
2014
31
Specific features of a rare form of disseminated necrobiosis lipoidica granuloma annulare type: a case report. ( 25611281 )
2014
32
Necrobiosis lipoidica. ( 24600675 )
2014
33
Effectiveness of platelet-rich plasma in healing necrobiosis lipoidica diabeticorum ulcers. ( 25266162 )
2014
34
Adipophilin Expression in Necrobiosis Lipoidica, Granuloma Annulare, and Sarcoidosis. ( 25357017 )
2014
35
Clearance of atypical facial necrobiosis lipoidica with tacrolimus ointment. ( 25353715 )
2014
36
Ulcerative necrobiosis lipoidica successfully treated with photodynamic therapy: Case report and literature review. ( 25150669 )
2014
37
Dermoscopy of necrobiosis lipoidica. ( 23084882 )
2013
38
Dermoscopy of necrobiosis lipoidica and granuloma annulare. ( 23797090 )
2013
39
Dermoscopic patterns of granuloma annulare and necrobiosis lipoidica. ( 23495727 )
2013
40
Ulcerated necrobiosis lipoidica as a rare cause for chronic leg ulcers: case report series of ten patients. ( 24119190 )
2013
41
Pigmented necrobiosis lipoidica accompanied by insulin-dependent diabetes mellitus induces CD163a8_ proinflammatory macrophages and interleukin-17-producing cells. ( 23165891 )
2013
42
A diabetic child with lesions over his legs. Necrobiosis lipoidica diabeticorum. ( 23841546 )
2013
43
Necrobiosis lipoidica. ( 24392215 )
2013
44
Necrobiosis lipoidica: A clinicopathological study in the Indian scenario. ( 24350007 )
2013
45
Remission of ulcerated necrobiosis lipoidica diabeticorum after bariatric surgery. ( 23762652 )
2013
46
Hyperkeratotic necrobiosis lipoidica. ( 23785630 )
2013
47
Necrobiotic Granulomatous Tattoo Reaction: Report of an Unusual Case Showing Features of Both Necrobiosis Lipoidica and Granuloma Annulare Patterns. ( 24335518 )
2013
48
Large plaques in a patient with diabetes. Diagnosis: Necrobiosis lipoidica. ( 24069666 )
2013
49
Squamous cell carcinoma arising in ulcerated necrobiosis lipoidica diabeticorum. ( 24373177 )
2013
50
Perforating disseminated necrobiosis lipoidica diabeticorum. ( 23533835 )
2013

Variations for Necrobiosis Lipoidica

Expression for Necrobiosis Lipoidica

Search GEO for disease gene expression data for Necrobiosis Lipoidica.

Pathways for Necrobiosis Lipoidica

Pathways related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.36 INS SLC2A1
2 11.25 INS SLC2A1
3 10.99 SLC2A1 TNFRSF1B
4
Show member pathways
10.65 SLC2A1 TNFRSF1B
5 9.83 INS SLC2A1

GO Terms for Necrobiosis Lipoidica

Biological processes related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA replication GO:0045740 9.16 GLI1 INS
2 glucose transport GO:0015758 8.96 INS SLC2A1
3 acute-phase response GO:0006953 8.62 CD163 INS

Sources for Necrobiosis Lipoidica

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