MCID: NCR002
MIFTS: 37

Necrobiosis Lipoidica malady

Skin category

Summaries for Necrobiosis Lipoidica

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes but... more...

MalaCards: Necrobiosis Lipoidica is related to granuloma annulare and lip disease. An important gene associated with Necrobiosis Lipoidica is GLI1 (GLI family zinc finger 1), and among its related pathways are AMPK Enzyme Complex Pathway and Insulin secretion. The compounds glimepiride and aicar have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and pancreas, and related mouse phenotypes are embryogenesis and no phenotypic analysis.

Aliases & Classifications for Necrobiosis Lipoidica

Sources:
8Disease Ontology, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 25ICD10
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Related Diseases for Necrobiosis Lipoidica

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to necrobiosis lipoidica

Clinical Features for Necrobiosis Lipoidica

Drugs & Therapeutics for Necrobiosis Lipoidica

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Necrobiosis Lipoidica

Search CenterWatch for Necrobiosis Lipoidica

Genetic Tests for Necrobiosis Lipoidica

Anatomical Context for Necrobiosis Lipoidica

Sources:
33MalaCards
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MalaCards organs/tissues related to Necrobiosis Lipoidica:

33
Skin, Kidney, Pancreas, Thyroid, B cells, Endothelial

Animal Models for Necrobiosis Lipoidica or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Necrobiosis Lipoidica:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.5SLC2A1, INS, GLI1
2MP:00030128.2SLC2A1, INS, GLI1

Publications for Necrobiosis Lipoidica

Sources:
51PubMed
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Articles related to Necrobiosis Lipoidica:

(show top 50)    (show all 354)
idTitleAuthorsYear
1
Necrobiosis lipoidica diabeticorum: necrobiosis lipoidica diabeticorum in a Nigerian from the north. A case report. (24283101)
2013
2
Fractional CO2 laser: a novel therapeutic device for refractory necrobiosis lipoidica. (23210760)
2012
3
Treatment of ulcerative necrobiosis lipoidica with topical calcineurin inhibitor: case report and literature review. (23149208)
2012
4
Treatment of pre-ulcerative necrobiosis lipoidica with infliximab. (21547338)
2011
5
Necrobiosis lipoidica: early diagnosis and treatment with tacrolimus. (21577369)
2011
6
Necrobiosis lipoidica. (22031644)
2011
7
Significant improvement in ulcerative necrobiosis lipoidica with hydroxychloroquine. (20465710)
2010
8
Fumaric acid esters in severe ulcerative necrobiosis lipoidica: a case report and evaluation of current therapies. (20107745)
2010
9
Detection of spirochaetal microorganisms by focus floating microscopy in necrobiosis lipoidica in patients from central Europe. (18462358)
2008
10
Necrobiosis lipoidica and cutaneous anaesthesia: immunohistochemical study of neural fibres. (18587710)
2008
11
Necrobiosis lipoidica: a case with histopathological findings revealed asteroid bodies and was successfully treated with dipyridamole plus intralesional triamcinolone. (18273726)
2008
12
Systemic corticosteroids for the outpatient treatment of necrobiosis lipoidica in a diabetic patient. (17671885)
2007
13
Treatment of necrobiosis lipoidica with pioglitazone. (17938022)
2007
14
Atypical form of necrobiosis lipoidica associated with lymphoedema. (17567322)
2007
15
Visual vignette. Necrobiosis lipoidica. (17599869)
2007
16
Thalidomide for the treatment of refractory necrobiosis lipoidica. (16415381)
2006
17
gli-1 Oncogene is highly expressed in granulomatous skin disorders, including sarcoidosis, granuloma annulare, and necrobiosis lipoidica diabeticorum. (15724024)
2005
18
Clearance of necrobiosis lipoidica with fumaric acid esters. (14657645)
2003
19
Recurrent necrobiosis lipoidica diabeticorum associated with venous insufficiency in an adolescent with poorly controlled type 2 diabetes mellitus. (12183729)
2002
20
Necrobiosis lipoidica in Prader- Willi-associated diabetes mellitus. (12358882)
2002
21
Necrobiosis lipoidica-like skin lesions in systemic sarcoidosis. (9830264)
1998
22
Necrobiosis lipoidica and diabetic control revisited. (8733162)
1996
23
An unusual case of giant dermatofibroma in a patient with diabetes mellitus and necrobiosis lipoidica. (8894427)
1996
24
Endothelin-1 expression is not altered in necrobiosis lipoidica and granuloma annulare. (8011514)
1994
25
Expression of interstitial collagenase, 92-kDa gelatinase, and tissue inhibitor of metalloproteinases-1 in granuloma annulare and necrobiosis lipoidica diabeticorum. (8382717)
1993
26
Necrobiosis lipoidica diabeticorum: association with background retinopathy, smoking, and proteinuria. A case controlled study. (8261754)
1993
27
Anti-collagen antibodies in granuloma annulare and necrobiosis lipoidica. (3246092)
1988
28
Pentoxifylline for necrobiosis lipoidica diabeticorum. (3624574)
1987
29
Necrobiosis lipoidica diabeticorum associated with familial hypo-beta-lipoproteinemia. (3429100)
1987
30
Necrobiosis lipoidica and sarcoidosis. (3427817)
1987
31
Squamous cell carcinoma arising in long-standing necrobiosis lipoidica. (3966816)
1985
32
Sweat gland disturbances in granuloma annulare and necrobiosis lipoidica. (6860561)
1983
33
Polymorphonuclear and mononuclear leucocyte function in necrobiosis lipoidica and granuloma annulare. (6847243)
1983
34
Serum beta-glucuronidase activity in human diabetes mellitus, granuloma annulare and necrobiosis lipoidica. (6883796)
1983
35
Perilesional heparin injections for necrobiosis lipoidica. (6863654)
1983
36
Fibrinolytic agents in the treatment of necrobiosis lipoidica. (629423)
1978
37
Sclerosing lipogranuloma. Necrobiosis lipoidica. (1236554)
1975
38
Necrobiosis lipoidica diabeticorum involving scalp and face. (1240765)
1975
39
Diabetic dermangiopathy.A spectrum including pigmented pretibial patches and necrobiosis lipoidica diabeticorum. (5484714)
1970
40
Necrobiosis lipoidica diabeticorum. (6075931)
1967
41
Necrobiosis lipoidica diabeticorum histopathologic study of 98 cases. (5938218)
1966
42
NECROBIOSIS LIPOIDICA?DIABETICORUM. (14107651)
1964
43
NECROBIOSIS LIPOIDICA DIABETICORUM: ITS RELATIONSHIP TO OTHER COMPLICATIONS OF DIABETES. (14082174)
1963
44
Necrobiosis lipoidica in a three-year-old girl. (13692874)
1961
45
Necrobiosis lipoidica. (18905000)
1948
46
Necrobiosis lipoidica (nondiabetic). (20277313)
1946
47
Necrobiosis lipoidica. (21064474)
1946
48
Necrobiosis lipoidica diabeticorum without diabetes. (20992535)
1946
49
Non-diabetic necrobiosis lipoidica. (21065686)
1945
50
A Case Clinically Resembling MorphA9a with a Tuberculous Background and Indeterminate Histology, suggestive of Necrobiosis Lipoidica. (20915489)
1937

Genetic Variations for Necrobiosis Lipoidica

Expression for genes affiliated with Necrobiosis Lipoidica

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Necrobiosis Lipoidica

Search GEO for disease gene expression data for Necrobiosis Lipoidica.

Pathways for genes affiliated with Necrobiosis Lipoidica

Sources:
52QIAGEN, 30KEGG, 54Reactome, 12EMD Millipore
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Pathways related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1SLC2A1, INS
29.1SLC2A1, INS
39.1INS, SLC2A1
4
Hide members
9.1SLC2A1, INS
59.1SLC2A1, INS

Compounds for genes affiliated with Necrobiosis Lipoidica

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1glimepiride45 50 1111.4SLC2A1, INS
2aicar45 11 2411.4SLC2A1, INS
3alpha lipoic acid459.4SLC2A1, INS
4olanzapine50 45 29 11 2413.4INS, SLC2A1
5glibenclamide45 29 50 6012.4SLC2A1, INS
62-deoxyglucose45 1110.3SLC2A1, INS
7metformin45 50 1111.3SLC2A1, INS
8pioglitazone45 50 29 1112.2SLC2A1, INS
9palmitate459.1INS, SLC2A1
10ibmx45 29 6011.1SLC2A1, INS
11glucose459.1SLC2A1, GLI1
12rosiglitazone45 50 29 11 2413.0SLC2A1, INS
13troglitazone45 29 60 1111.8SLC2A1, INS
14phosphatidylinositol458.7GLI1, INS, SLC2A1

GO Terms for genes affiliated with Necrobiosis Lipoidica

Sources:
16Gene Ontology
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Biological processes related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of DNA replicationGO:0457409.3INS, GLI1
2energy reserve metabolic processGO:0061129.1SLC2A1, INS
3glucose transportGO:0157589.0SLC2A1, INS
4regulation of insulin secretionGO:0507968.8SLC2A1, INS

Products for genes affiliated with Necrobiosis Lipoidica

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  • Proteins
  • Lysates
  • Antibodies

Sources for Necrobiosis Lipoidica

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet