MCID: NCR002
MIFTS: 39

Necrobiosis Lipoidica malady

Skin diseases category

Summaries for Necrobiosis Lipoidica

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63Wikipedia, 32MalaCards
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Wikipedia:63 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes but... more...

MalaCards: Necrobiosis Lipoidica is related to proteinuria and retinal disease. An important gene associated with Necrobiosis Lipoidica is GLI1 (GLI family zinc finger 1), and among its related pathways are AMPK Enzyme Complex Pathway and Insulin secretion. The compounds glimepiride and aicar have been mentioned in the context of this disorder. Affiliated tissues include skin, pancreas and kidney, and related mouse phenotypes are embryogenesis and no phenotypic analysis.

Aliases & Classifications for Necrobiosis Lipoidica

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Necrobiosis Lipoidica

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to necrobiosis lipoidica

Clinical Features for Necrobiosis Lipoidica

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Drugs & Therapeutics for Necrobiosis Lipoidica

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Necrobiosis Lipoidica

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Genetic Tests for Necrobiosis Lipoidica

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Anatomical Context for Necrobiosis Lipoidica

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32MalaCards
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MalaCards organs/tissues related to Necrobiosis Lipoidica:

32
Skin, Pancreas, Kidney, Endothelial, Testes, Eye, Thyroid

Animal Models for Necrobiosis Lipoidica or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Necrobiosis Lipoidica:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.5SLC2A1, INS, GLI1
2MP:00030128.2SLC2A1, INS, GLI1

Publications for Necrobiosis Lipoidica

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50PubMed
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Articles related to Necrobiosis Lipoidica:

(show top 50)    (show all 354)
idTitleAuthorsYear
1
Hyperkeratotic necrobiosis lipoidica. (23785630)
2013
2
Necrobiosis lipoidica diabeticorum in a tattoo site. (22784523)
2012
3
Ulcerative necrobiosis lipoidica responsive to colchicine. (22881474)
2012
4
Necrobiosis lipoidica diabeticorum. (22606526)
2012
5
Ulcerative necrobiosis lipoidica successfully treated by vacuum-assisted closure therapy. (21700546)
2011
6
Resolution of long-standing necrobiosis lipoidica diabeticorum (NLD) lesion after restoration of euglycemia following successful pancreas after kidney (PAK) transplantation: a case report. (22099781)
2011
7
Pretibial angioplasia: a novel entity encompassing the clinical features of necrobiosis lipoidica and the histopathology of venous insufficiency. (21291651)
2011
8
Links between granuloma annulare, necrobiosis lipoidica diabeticorum and childhood diabetes: a matter of time? (20537071)
2010
9
Necrobiosis lipoidica diabeticorum. (16206686)
2005
10
Generalized necrobiosis lipoidica treated with a combination of split-thickness autografting and immunomodulatory therapy. (15533073)
2004
11
Squamous cell carcinoma arising in long-standing necrobiosis lipoidica. (15009305)
2004
12
Ulcerated necrobiosis lipoidica treated with cyclosporin A. (12735655)
2003
13
A prospective open study of topical psoralen-UV-A therapy for Necrobiosis lipoidica. (11735728)
2001
14
Expression of the human erythrocyte glucose transporter Glut-1 in areas of sclerotic collagen in necrobiosis lipoidica. (11401674)
2001
15
Necrobiosis lipoidica: only a minority of patients have diabetes mellitus. (10233223)
1999
16
Pulsed dye laser treatment of necrobiosis lipoidica: report of a case. (11360467)
1999
17
Necrobiosis lipoidica diabeticorum and thyroid disease. (9372361)
1997
18
Necrobiosis lipoidica in a diabetic intravenous drug user. (9341590)
1997
19
Topically applied bovine collagen in the treatment of ulcerative necrobiosis lipoidica diabeticorum. (9236518)
1997
20
Ulcerating necrobiosis lipoidica effectively treated with pentoxifylline. (8440063)
1993
21
A case of necrobiosis lipoidica treated with systemic corticosteroid. (8340536)
1993
22
Treatment of necrobiosis lipoidica diabeticorum by hyperbaric oxygen. (7906460)
1993
23
Images in clinical medicine. Necrobiosis lipoidica diabeticorum. (8355766)
1993
24
Periorbital necrobiosis lipoidica. (1739694)
1992
25
Rapid healing of ulcerated necrobiosis lipoidica with optimum glycaemic control and seaweed-based dressings. (1760369)
1991
26
Necrobiosis lipoidica and sarcoidosis. (1794173)
1991
27
Focal endothelial cell degeneration and proliferative endarteritis in trauma-induced early lesions of necrobiosis lipoidica diabeticorum. (2029086)
1991
28
Necrobiosis lipoidica. (1802895)
1991
29
Koebner's phenomenon and necrobiosis lipoidica diabeticorum. (2102235)
1990
30
High dose nicotinamide in the treatment of necrobiosis lipoidica. (2969260)
1988
31
Granuloma annulare, necrobiosis lipoidica, and diabetic disease. (3209319)
1988
32
Necrobiosis lipoidica diabeticorum: a clinicopathologic study. (3351015)
1988
33
Skin blood flow in necrobiosis lipoidica during treatment with low-dose acetylsalicylic acid. (2459887)
1988
34
Necrobiosis lipoidica treated with ticlopidine. (2431591)
1986
35
Successful treatment of ulcerated necrobiosis: lipoidica diabeticorum with prostaglandin E1 and skin flap transfer--a case report. (3914497)
1985
36
Necrobiosis lipoidica: treatment with porcine dressings, split-thickness skin grafts and pressure garments. A case report and review of treatment modalities. (3904539)
1985
37
Necrobiosis lipoidica in two diabetic sisters. (3978863)
1985
38
Granuloma annulare, rheumatoid nodules and necrobiosis lipoidica. (884054)
1977
39
Necrobiosis lipoidica. (5038595)
1972
40
NECROBIOSIS LIPOIDICA DIABETICORUM. WITH APPARENTLY NORMAL CARBOHYDRATE TOLERANCE. (14299444)
1965
41
Current concepts of necrobiosis lipoidica. (13692875)
1961
42
Necrobiosis lipoidica diabeticorum. (13050193)
1953
43
Effects of topical cortisone on chronic discoid lupus erythematosus and necrobiosis lipoidica diabeticorum. (14850773)
1951
44
Necrobiosis lipoidica (diabeticorum?) a histologic study and comparison with granuloma annulare. (18113617)
1949
45
Necrobiosis lipoidica (diabeticorum). (18891981)
1948
46
Necrobiosis lipoidica diabeticorum. (20251581)
1947
47
Necrobiosis lipoidica with increased sugar tolerance a case report. (20259992)
1947
48
Necrobiosis Lipoidica (Without Diabetes). (19992942)
1944
49
A Case Clinically Resembling Morphoea with a Tuberculous Background and Indeterminate Histology, suggestive of Necrobiosis Lipoidica. (19991092)
1937
50
Necrobiosis Lipoidica. (19990125)
1935

Genetic Variations for Necrobiosis Lipoidica

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Expression for genes affiliated with Necrobiosis Lipoidica

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Necrobiosis Lipoidica

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Pathways for genes affiliated with Necrobiosis Lipoidica

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51QIAGEN, 29KEGG, 53Reactome, 12EMD Millipore
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Pathways related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1SLC2A1, INS
29.1SLC2A1, INS
39.1INS, SLC2A1
4
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9.1SLC2A1, INS
59.1SLC2A1, INS

Compounds for genes affiliated with Necrobiosis Lipoidica

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1glimepiride44 49 1111.4SLC2A1, INS
2aicar44 11 2411.4SLC2A1, INS
3alpha lipoic acid449.4SLC2A1, INS
4olanzapine49 44 28 11 2413.4INS, SLC2A1
5glibenclamide44 28 49 5912.4SLC2A1, INS
62-deoxyglucose44 1110.3SLC2A1, INS
7metformin44 49 1111.3SLC2A1, INS
8pioglitazone44 49 28 1112.2SLC2A1, INS
9palmitate449.1INS, SLC2A1
10ibmx44 28 5911.1SLC2A1, INS
11glucose449.1SLC2A1, GLI1
12rosiglitazone44 49 28 11 2413.0SLC2A1, INS
13troglitazone44 28 59 1111.8SLC2A1, INS
14phosphatidylinositol448.7GLI1, INS, SLC2A1

GO Terms for genes affiliated with Necrobiosis Lipoidica

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16Gene Ontology
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Biological processes related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of DNA replicationGO:0457409.3INS, GLI1
2energy reserve metabolic processGO:0061129.1SLC2A1, INS
3glucose transportGO:0157589.0SLC2A1, INS
4regulation of insulin secretionGO:0507968.8SLC2A1, INS

Products for genes affiliated with Necrobiosis Lipoidica

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  • Antibodies
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Sources for Necrobiosis Lipoidica

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet