MCID: NCR002
MIFTS: 43

Necrobiosis Lipoidica malady

Skin diseases category

Summaries for Necrobiosis Lipoidica

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66Wikipedia, 34MalaCards
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Wikipedia:66 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes but... more...

MalaCards: Necrobiosis Lipoidica is related to diabetes mellitus and type 2 diabetes mellitus. An important gene associated with Necrobiosis Lipoidica is GLI1 (GLI family zinc finger 1), and among its related pathways are Pathways in cancer and AMPK Enzyme Complex Pathway. The compounds mannose and pd 98,059 have been mentioned in the context of this disorder. Affiliated tissues include skin, pancreas and kidney, and related mouse phenotypes are embryogenesis and no phenotypic analysis.

Aliases & Classifications for Necrobiosis Lipoidica

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9Disease Ontology, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 26ICD10
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Related Diseases for Necrobiosis Lipoidica

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to necrobiosis lipoidica

Symptoms for Necrobiosis Lipoidica

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Drugs & Therapeutics for Necrobiosis Lipoidica

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Necrobiosis Lipoidica

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Genetic Tests for Necrobiosis Lipoidica

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Anatomical Context for Necrobiosis Lipoidica

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34MalaCards
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MalaCards organs/tissues related to Necrobiosis Lipoidica:

34
Skin, Pancreas, Kidney, Endothelial, Eye, Testes, Thyroid

Animal Models for Necrobiosis Lipoidica or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Necrobiosis Lipoidica:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.5SLC2A1, GLI1, INS
2MP:00030128.2SLC2A1, GLI1, INS

Publications for Necrobiosis Lipoidica

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53PubMed
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Articles related to Necrobiosis Lipoidica:

(show top 50)    (show all 351)
idTitleAuthorsYear
1
Necrobiosis lipoidica diabeticorum: necrobiosis lipoidica diabeticorum in a Nigerian from the north. A case report. (24283101)
2013
2
Long-term successful healing of ulcerated necrobiosis lipoidica after topical therapy with becaplermin. (23962308)
2013
3
Unsightly rash on shin. Necrobiosis lipoidica diabeticorum. (22482106)
2012
4
Case of necrobiosis lipoidica diabeticorum successfully treated by photodynamic therapy. (21950273)
2012
5
Treatment of pre-ulcerative necrobiosis lipoidica with infliximab. (21547338)
2011
6
Ulcerative necrobiosis lipoidica successfully treated by vacuum-assisted closure therapy. (21700546)
2011
7
Arcuate plaques of the face and scalp. Atypical necrobiosis lipoidica (ANL) of the face and scalp. (20831607)
2010
8
Significant improvement in ulcerative necrobiosis lipoidica with hydroxychloroquine. (20465710)
2010
9
Necrobiosis lipoidica in monozygotic twins. (18209185)
2008
10
Detection of spirochaetal microorganisms by focus floating microscopy in necrobiosis lipoidica in patients from central Europe. (18462358)
2008
11
Necrobiosis lipoidica. (17544959)
2007
12
Clinical and pathologic manifestations of necrobiosis lipoidica-like skin involvement in sarcoidosis. (18092383)
2007
13
Images in clinical medicine. Necrobiosis lipoidica diabeticorum. (17079756)
2006
14
Successful treatment of necrobiosis lipoidica diabeticorum with photodynamic therapy. (17178979)
2006
15
What is necrobiosis lipoidica? (15879976)
2005
16
Necrobiosis lipoidica diabeticorum. (16206686)
2005
17
Epidermoid carcinoma and perforating necrobiosis lipoidica: a rare association. (16268888)
2005
18
Generalized necrobiosis lipoidica treated with a combination of split-thickness autografting and immunomodulatory therapy. (15533073)
2004
19
Clearance of necrobiosis lipoidica with fumaric acid esters. (14657645)
2003
20
Necrobiosis lipoidica associated with KAPbner's phenomenon in a patient with diabetes. (11236227)
2001
21
Tissue-engineered dermal skin grafting in the treatment of ulcerated necrobiosis lipoidica. (11298110)
2001
22
Persistent ulcerated necrobiosis lipoidica responding to treatment with cyclosporin. (10583126)
1999
23
Necrobiosis lipoidica: treatment by hyperbaric oxygen and local corticosteroids. (9592641)
1998
24
Necrobiosis lipoidica-like skin lesions in systemic sarcoidosis. (9830264)
1998
25
Necrobiosis lipoidica diabeticorum and thyroid disease. (9372361)
1997
26
Necrobiosis lipoidica in a diabetic intravenous drug user. (9341590)
1997
27
Necrobiosis lipoidica mimicking cellulitis. (20944321)
1997
28
Endothelin-1 expression is not altered in necrobiosis lipoidica and granuloma annulare. (8011514)
1994
29
Ulceration in necrobiosis lipoidica--a case report and study. (8403479)
1993
30
Ulcerating necrobiosis lipoidica effectively treated with pentoxifylline. (8440063)
1993
31
Familial non-diabetic necrobiosis lipoidica. (1445090)
1992
32
Periorbital necrobiosis lipoidica. (1390543)
1992
33
A new histopathologic feature of necrobiosis lipoidica diabeticorum: lymphoid nodules. (3372792)
1988
34
Pentoxifylline for necrobiosis lipoidica diabeticorum. (3624574)
1987
35
Successful treatment of ulcerated necrobiosis: lipoidica diabeticorum with prostaglandin E1 and skin flap transfer--a case report. (3914497)
1985
36
Squamous cell carcinoma arising in long-standing necrobiosis lipoidica. (3966816)
1985
37
Necrobiosis lipoidica: treatment with porcine dressings, split-thickness skin grafts and pressure garments. A case report and review of treatment modalities. (3904539)
1985
38
Direct immunofluorescence studies in granuloma annulare, necrobiosis lipoidica and granulomatosis disciformis Miescher. (381068)
1979
39
Granuloma annulare, rheumatoid nodules and necrobiosis lipoidica. (884054)
1977
40
Proceedings: Necrobiosis lipoidica diabeticorum disseminata. (4811828)
1974
41
Capillaroscopic changes in the course of necrobiosis lipoidica. (5782165)
1969
42
Atypical forms of necrobiosis lipoidica diabeticorum. A report of three cases. (5905217)
1966
43
Necrobiosis lipoidica granulomatosis. Necrobiosis lipoidica diabeticorum in the nondiabetic. (13742950)
1960
44
Scirrhous Metastasis Simulating Necrobiosis Lipoidica. (19993878)
1956
45
Necrobiosis lipoidica diabeticorum with intercapillary glomerulosclerosis. (14360798)
1955
46
Necrobiosis lipoidica. (13269650)
1955
47
Necrobiosis lipoidica diabeticorum following pyoderma. (18208051)
1948
48
Necrobiosis lipoidica diabeticorum. (18100968)
1948
49
Necrobiosis lipoidica without diabetes. (21065490)
1945
50
Necrobiosis Lipoidica Diabeticorum. (19991166)
1937

Variations for Necrobiosis Lipoidica

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Expression for genes affiliated with Necrobiosis Lipoidica

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Necrobiosis Lipoidica

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Pathways for genes affiliated with Necrobiosis Lipoidica

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51PathCards, 31KEGG, 54QIAGEN, 56Reactome, 39NCBI BioSystems Database, 13EMD Millipore
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Compounds for genes affiliated with Necrobiosis Lipoidica

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46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1mannose469.5SLC2A1, CD163
2pd 98,059469.4SLC2A1, GLI1
3glimepiride46 52 1211.4SLC2A1, INS
4aicar46 25 1211.4SLC2A1, INS
5alpha lipoic acid469.4INS, SLC2A1
6glibenclamide46 30 52 6212.4SLC2A1, INS
72-deoxyglucose46 1210.4SLC2A1, INS
8metformin46 52 1211.3INS, SLC2A1
9olanzapine46 52 30 25 1213.3SLC2A1, INS
10paraffin469.3SLC2A1, CD163
11pioglitazone30 46 52 1212.3INS, SLC2A1
12palmitate469.3INS, SLC2A1
13rosiglitazone30 46 52 25 1213.3SLC2A1, INS
14troglitazone46 30 62 1212.2INS, SLC2A1
15ibmx46 62 3011.2SLC2A1, INS
16rapamycin469.1INS, SLC2A1
17ly294002469.0SLC2A1, INS
18wortmannin468.9INS, SLC2A1
19dexamethasone46 52 30 1211.8SLC2A1, CD163, INS
20phosphatidylinositol468.8SLC2A1, GLI1, INS
21glucose468.8SLC2A1, GLI1, INS
22glycogen46 259.7SLC2A1, INS

GO Terms for genes affiliated with Necrobiosis Lipoidica

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17Gene Ontology
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Biological processes related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.2CD163, INS
2positive regulation of DNA replicationGO:0457409.1GLI1, INS
3energy reserve metabolic processGO:0061129.0SLC2A1, INS
4glucose transportGO:0157588.9INS, SLC2A1
5regulation of insulin secretionGO:0507968.7SLC2A1, INS

Molecular functions related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.0SLC2A1, CD163, GLI1, INS

Products for genes affiliated with Necrobiosis Lipoidica

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  • Antibodies
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Sources for Necrobiosis Lipoidica

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet