MCID: NCR002
MIFTS: 35

Necrobiosis Lipoidica

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Necrobiosis Lipoidica

Summaries for Necrobiosis Lipoidica

NIH Rare Diseases : 49 Necrobiosis lipoidica is a rare skin disorder of collagen degeneration. It is characterized by a rash that occurs on the lower legs. It is more common in women, and there are usually several spots. They are slightly raised shiny red-brown patches. The centers are often yellowish and may develop open sores that are slow to heal. Infections can occur but are uncommon. Some patients have itching, pain, or abnormal sensations. It usually occurs more often in people with diabetes, in people with a family history of diabetes or a tendency to get diabetes, but can occur in nondiabetic people. About 11% to 65% of patients with necrobiosis lipoidica also have diabetes, but the exact cause is still not known. Treatment is difficult. The disease is typically chronic with variable progression and scarring. Last updated: 6/6/2016

MalaCards based summary : Necrobiosis Lipoidica is related to granuloma annulare and diabetes mellitus. An important gene associated with Necrobiosis Lipoidica is CD163 (CD163 Molecule), and among its related pathways/superpathways are Insulin resistance and HIF-1 signaling pathway. Affiliated tissues include skin, pancreas and thyroid, and related phenotypes are cellular and vision/eye

Wikipedia : 72 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes... more...

Related Diseases for Necrobiosis Lipoidica

Diseases related to Necrobiosis Lipoidica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 granuloma annulare 30.7 GLI1 TNFRSF1B
2 diabetes mellitus 10.6
3 squamous cell carcinoma 10.4
4 venous insufficiency 10.3
5 rheumatoid arthritis 10.2
6 arthritis 10.2
7 skin sarcoidosis 10.2
8 thyroiditis 10.2
9 balanitis 10.1
10 pustulosis of palm and sole 10.1
11 angiokeratoma 10.1
12 psoriasis 10.1
13 endotheliitis 10.1
14 blood group, i system 10.0
15 hashimoto thyroiditis 10.0
16 neutrophil migration 10.0
17 ataxia-telangiectasia 10.0
18 body mass index quantitative trait locus 11 10.0
19 ataxia and polyneuropathy, adult-onset 10.0
20 body mass index quantitative trait locus 9 10.0
21 body mass index quantitative trait locus 8 10.0
22 maturity-onset diabetes of the young 10.0
23 vitiligo-associated multiple autoimmune disease susceptibility 1 10.0
24 body mass index quantitative trait locus 4 10.0
25 body mass index quantitative trait locus 10 10.0
26 kala-azar 1 10.0
27 body mass index quantitative trait locus 7 10.0
28 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
29 body mass index quantitative trait locus 12 10.0
30 body mass index quantitative trait locus 14 10.0
31 body mass index quantitative trait locus 18 10.0
32 common variable immunodeficiency 10.0
33 cutaneous leishmaniasis 10.0
34 lymphomatoid granulomatosis 10.0
35 skin disease 10.0
36 hypothyroidism 10.0
37 dermatitis 10.0
38 histiocytosis 10.0
39 cellulitis 10.0
40 retinitis 10.0
41 syphilis 10.0
42 pyoderma 10.0
43 retinal disease 10.0
44 tertiary syphilis 10.0
45 lupus erythematosus 10.0
46 leishmaniasis 10.0
47 necrobiotic xanthogranuloma 10.0
48 discoid lupus erythematosus 10.0
49 central nervous system tuberculosis 9.9 CD163 GLI1
50 chronic salpingitis 9.6 SLC2A1 TNFRSF1B

Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to Necrobiosis Lipoidica

Symptoms & Phenotypes for Necrobiosis Lipoidica

MGI Mouse Phenotypes related to Necrobiosis Lipoidica:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.35 SLC2A1 TNFRSF1B CD163 GLI1 INS
2 vision/eye MP:0005391 8.92 CD163 INS RDH11 TNFRSF1B

Drugs & Therapeutics for Necrobiosis Lipoidica

Search Clinical Trials , NIH Clinical Center for Necrobiosis Lipoidica

Cochrane evidence based reviews: necrobiosis lipoidica

Genetic Tests for Necrobiosis Lipoidica

Anatomical Context for Necrobiosis Lipoidica

MalaCards organs/tissues related to Necrobiosis Lipoidica:

38
Skin, Pancreas, Thyroid, Endothelial, Neutrophil, Kidney, Tongue

Publications for Necrobiosis Lipoidica

Articles related to Necrobiosis Lipoidica:

(show top 50) (show all 404)
# Title Authors Year
1
Necrobiosis lipoidica with mucin deposition in a patient with autoimmune thyroiditis. ( 29411412 )
2018
2
Refractory Ulcerated Necrobiosis Lipoidica: Closure of a Difficult Wound with Topical Tacrolimus. ( 28914682 )
2017
3
Atypical Localization of Necrobiosis Lipoidica: Involvement of the Face and Scalp. ( 28560219 )
2017
4
A systematic review of the relationship between glycemic control and necrobiosis lipoidica diabeticorum in patients with diabetes mellitus. ( 28650076 )
2017
5
Necrobiosis lipoidica following Q-switched laser tattoo removal. ( 28660728 )
2017
6
Update: Therapie der Necrobiosis lipoidica. ( 28214306 )
2017
7
Ulcerative necrobiosis lipoidica in the setting of anti-tumor necrosis factor-I+ and hydroxychloroquine treatment for rheumatoid arthritis. ( 28331899 )
2017
8
Narrow-band UVB for pretibial (necrobiosis lipoidica-like) involvement of cutaneous sarcoidosis: a promising therapeutic option. ( 28681723 )
2017
9
A case of annular elastolytic giant cell granuloma on unusual sites requiring the differential diagnosis of necrobiosis lipoidica. ( 28698165 )
2017
10
Necrobiosis lipoidica developing within a surgical scar in a non-diabetic patient: Type III Koebner phenomenon (isomorphic response), Wolf's isotopic response or Ruocco's immunocompromised cutaneous district? ( 28071608 )
2017
11
Update: Treatment of necrobiosis lipoidica. ( 28214312 )
2017
12
Granulomatous skin disease with a histological pattern of palisading granuloma - an atypical facial necrobiosis lipoidica or more? ( 29422829 )
2017
13
Necrobiosis Lipoidica ( 29083569 )
2017
14
A granulomatous conundrum: Concurrent necrobiosis lipoidica, cutaneous sarcoidosis and erythema nodosum in a nondiabetic patient. ( 28211041 )
2017
15
Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012. ( 26972191 )
2016
16
Necrobiosis Lipoidica. ( 27686584 )
2016
17
Kofaktoren und KomorbiditAoten bei Necrobiosis lipoidica - Analyse der deutschen DRG-Daten von 2012. ( 26972192 )
2016
18
Sarcoidal Necrobiosis Lipoidica in a Nondiabetic Patient: Usefulness of Skin Ultrasound. ( 27001349 )
2016
19
Necrobiosis lipoidica of the glans penis: a case report and literature review. ( 27767287 )
2016
20
Necrobiosis lipoidica der Peniseichel: ein Fallbericht mit LiteraturA1berblick. ( 27767276 )
2016
21
Risk factors for necrobiosis lipoidica in Type 1 diabetes mellitus. ( 27101431 )
2016
22
Anti-TNFI+ treatment for recalcitrant ulcerative necrobiosis lipoidica diabeticorum: A case report and review of the literature. ( 26975548 )
2016
23
Pediatric-onset necrobiosis lipoidica. ( 26865027 )
2016
24
Treatment of refractory ulcerative necrobiosis lipoidica diabeticorum with oral thalidomide. ( 26951036 )
2016
25
Scald-Induced Necrobiosis Lipoidica in a Patient with Diabetes Mellitus and Psoriasis. ( 26889139 )
2016
26
Necrobiosis Lipoidica. ( 27771664 )
2016
27
Necrobiosis lipoidica associated with Hashimoto's thyroiditis and positive detection of ANA and ASMA autoantibodies. ( 26273437 )
2015
28
Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study. ( 26575980 )
2015
29
Granuloma annulare and necrobiosis lipoidica with sequential occurrence in a patient: report and review of literature. ( 25692078 )
2015
30
Necrobiosis Lipoidica. ( 26143418 )
2015
31
Necrobiosis lipoidica diabeticorum. ( 26057508 )
2015
32
Pentoxifylline: An effective therapy for necrobiosis lipoidica. ( 26559761 )
2015
33
Necrobiosis Lipoidica: A Descriptive Study of 35 Cases. ( 25728565 )
2015
34
Treatment Modalities of Necrobiosis Lipoidica: A Concise Systematic Review. ( 26236446 )
2015
35
Necrobiosis lipoidica-like cutaneous leishmaniasis. ( 25368717 )
2014
36
Selective case study describing the use of Apligraf on necrobiosis lipoidica associated with diabetes. ( 24600755 )
2014
37
Ulcerated necrobiosis lipoidica to a teenager with diabetes mellitus and obesity. ( 24715184 )
2014
38
Residents'corner February 2014. DeRmpath & Clinic: differential diagnosis in palisading non-infectious granulomas. Diagnosis: Case 1: Granuloma annulare. Case 2: Necrobiosis lipoidica. ( 24691245 )
2014
39
Effectiveness of platelet-rich plasma in healing necrobiosis lipoidica diabeticorum ulcers. ( 25266162 )
2014
40
Palmoplantar pustulosis associated with necrobiosis lipoidica: a possible role of tumor necrosis factor-I+ and interleukin-17. ( 24628381 )
2014
41
Necrobiosis lipoidica with elastophagocytosis on an unusual location. ( 24786578 )
2014
42
Necrobiosis Lipoidica Diabeticorum: A pediatric case report. ( 24575162 )
2014
43
Ulcerative necrobiosis lipoidica successfully treated with photodynamic therapy: Case report and literature review. ( 25150669 )
2014
44
Necrobiosis lipoidica with infiltration of Th17 cells into vascular lesions. ( 24801926 )
2014
45
Specific features of a rare form of disseminated necrobiosis lipoidica granuloma annulare type: a case report. ( 25611281 )
2014
46
Necrobiosis lipoidica occurring in a patient with rheumatoid arthritis on concurrent tumor necrosis factor-I+ inhibitor therapy. ( 24697547 )
2014
47
Clearance of atypical facial necrobiosis lipoidica with tacrolimus ointment. ( 25353715 )
2014
48
Necrobiosis lipoidica. ( 24600675 )
2014
49
Adipophilin Expression in Necrobiosis Lipoidica, Granuloma Annulare, and Sarcoidosis. ( 25357017 )
2014
50
Necrobiosis lipoidica: A clinicopathological study in the Indian scenario. ( 24350007 )
2013

Variations for Necrobiosis Lipoidica

Expression for Necrobiosis Lipoidica

Search GEO for disease gene expression data for Necrobiosis Lipoidica.

Pathways for Necrobiosis Lipoidica

Pathways related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.36 INS SLC2A1
2 11.26 INS SLC2A1
3 10.99 SLC2A1 TNFRSF1B
4
Show member pathways
10.65 SLC2A1 TNFRSF1B
5 9.83 INS SLC2A1

GO Terms for Necrobiosis Lipoidica

Biological processes related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA replication GO:0045740 9.16 GLI1 INS
2 acute-phase response GO:0006953 8.96 CD163 INS
3 glucose transport GO:0015758 8.62 INS SLC2A1

Sources for Necrobiosis Lipoidica

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