MCID: NCR002
MIFTS: 32

Necrobiosis Lipoidica malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Necrobiosis Lipoidica

About this section

Summaries for Necrobiosis Lipoidica

About this section
NIH Rare Diseases:48 Necrobiosis lipoidica is a rare skin disorder of collagen degeneration. it is characterized by a rash that occurs on the lower legs. it is more common in women, and there are usually several spots. they are slightly raised shiny red-brown patches. the centers are often yellowish and may develop open sores that are slow to heal. infections can occur but are uncommon. some patients have itching, pain, or abnormal sensations. it usually occurs more often in people with diabetes, in people with a family history of diabetes or a tendency to get diabetes, but can occur in nondiabetic people. about 11% to 65% of patients with necrobiosis lipoidica also have diabetes, but the exact cause is still not known. treatment is difficult. the disease is typically chronic with variable progression and scarring. last updated: 6/6/2016

MalaCards based summary: Necrobiosis Lipoidica is related to granuloma annulare and squamous cell carcinoma. An important gene associated with Necrobiosis Lipoidica is CD163 (CD163 Molecule), and among its related pathways are Cellular Transformation by HTLV1 and Adipocytokine signaling pathway. Affiliated tissues include skin, pancreas and endothelial, and related mouse phenotypes are cellular and vision/eye.

Wikipedia:71 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes... more...

Related Diseases for Necrobiosis Lipoidica

About this section

Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to necrobiosis lipoidica

Symptoms & Phenotypes for Necrobiosis Lipoidica

About this section

MGI Mouse Phenotypes related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053848.4CD163, GLI1, INS, SLC2A1, TNFRSF1B
2MP:00053918.1CD163, INS, RDH11, TNFRSF1B

Drugs & Therapeutics for Necrobiosis Lipoidica

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Necrobiosis Lipoidica


Cochrane evidence based reviews: necrobiosis lipoidica

Genetic Tests for Necrobiosis Lipoidica

About this section

Anatomical Context for Necrobiosis Lipoidica

About this section

MalaCards organs/tissues related to Necrobiosis Lipoidica:

36
Skin, Pancreas, Endothelial, Neutrophil, Thyroid, Tongue, Kidney

Publications for Necrobiosis Lipoidica

About this section

Articles related to Necrobiosis Lipoidica:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Necrobiosis lipoidica developing within a surgical scar in a non-diabetic patient: Type III Koebner phenomenon (isomorphic response), Wolf's isotopic response or Ruocco's immunocompromised cutaneous district? (28071608)
2017
2
Anti-TNFI+ treatment for recalcitrant ulcerative necrobiosis lipoidica diabeticorum: A case report and review of the literature. (26975548)
2016
3
Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012. (26972191)
2016
4
Necrobiosis Lipoidica. (27686584)
2016
5
Sarcoidal Necrobiosis Lipoidica in a Nondiabetic Patient: Usefulness of Skin Ultrasound. (27001349)
2016
6
Necrobiosis Lipoidica. (27771664)
2016
7
Risk factors for necrobiosis lipoidica in Type 1 diabetes mellitus. (27101431)
2016
8
Necrobiosis lipoidica der Peniseichel: ein Fallbericht mit LiteraturA1berblick. (27767276)
2016
9
Kofaktoren und KomorbiditAoten bei Necrobiosis lipoidica - Analyse der deutschen DRG-Daten von 2012. (26972192)
2016
10
Pediatric-onset necrobiosis lipoidica. (26865027)
2016
11
Treatment of refractory ulcerative necrobiosis lipoidica diabeticorum with oral thalidomide. (26951036)
2016
12
Necrobiosis lipoidica of the glans penis: a case report and literature review. (27767287)
2016
13
Scald-Induced Necrobiosis Lipoidica in a Patient with Diabetes Mellitus and Psoriasis. (26889139)
2016
14
Treatment Modalities of Necrobiosis Lipoidica: A Concise Systematic Review. (26236446)
2015
15
Pentoxifylline: An effective therapy for necrobiosis lipoidica. (26559761)
2015
16
Necrobiosis lipoidica diabeticorum. (26057508)
2015
17
Granuloma annulare and necrobiosis lipoidica with sequential occurrence in a patient: report and review of literature. (25692078)
2015
18
Updated results of 100 patients on clinical features and therapeutic options in necrobiosis lipoidica in a retrospective multicentre study. (26575980)
2015
19
Necrobiosis Lipoidica: A Descriptive Study of 35 Cases. (25728565)
2015
20
Necrobiosis lipoidica associated with Hashimoto's thyroiditis and positive detection of ANA and ASMA autoantibodies. (26273437)
2015
21
Necrobiosis Lipoidica. (26143418)
2015
22
Residents'corner February 2014. DeRmpath & Clinic: differential diagnosis in palisading non-infectious granulomas. Diagnosis: Case 1: Granuloma annulare. Case 2: Necrobiosis lipoidica. (24691245)
2014
23
Selective case study describing the use of Apligraf on necrobiosis lipoidica associated with diabetes. (24600755)
2014
24
Necrobiosis lipoidica occurring in a patient with rheumatoid arthritis on concurrent tumor necrosis factor-I+ inhibitor therapy. (24697547)
2014
25
Ulcerated necrobiosis lipoidica to a teenager with diabetes mellitus and obesity. (24715184)
2014
26
Palmoplantar pustulosis associated with necrobiosis lipoidica: a possible role of tumor necrosis factor-I+ and interleukin-17. (24628381)
2014
27
Necrobiosis lipoidica-like cutaneous leishmaniasis. (25368717)
2014
28
Necrobiosis lipoidica with elastophagocytosis on an unusual location. (24786578)
2014
29
Necrobiosis Lipoidica Diabeticorum: A pediatric case report. (24575162)
2014
30
Necrobiosis lipoidica with infiltration of Th17 cells into vascular lesions. (24801926)
2014
31
Specific features of a rare form of disseminated necrobiosis lipoidica granuloma annulare type: a case report. (25611281)
2014
32
Necrobiosis lipoidica. (24600675)
2014
33
Effectiveness of platelet-rich plasma in healing necrobiosis lipoidica diabeticorum ulcers. (25266162)
2014
34
Adipophilin Expression in Necrobiosis Lipoidica, Granuloma Annulare, and Sarcoidosis. (25357017)
2014
35
Clearance of atypical facial necrobiosis lipoidica with tacrolimus ointment. (25353715)
2014
36
Ulcerative necrobiosis lipoidica successfully treated with photodynamic therapy: Case report and literature review. (25150669)
2014
37
Dermoscopy of necrobiosis lipoidica. (23084882)
2013
38
Dermoscopy of necrobiosis lipoidica and granuloma annulare. (23797090)
2013
39
Dermoscopic patterns of granuloma annulare and necrobiosis lipoidica. (23495727)
2013
40
Ulcerated necrobiosis lipoidica as a rare cause for chronic leg ulcers: case report series of ten patients. (24119190)
2013
41
Pigmented necrobiosis lipoidica accompanied by insulin-dependent diabetes mellitus induces CD163a8_ proinflammatory macrophages and interleukin-17-producing cells. (23165891)
2013
42
A diabetic child with lesions over his legs. Necrobiosis lipoidica diabeticorum. (23841546)
2013
43
Necrobiosis lipoidica. (24392215)
2013
44
Necrobiosis lipoidica: A clinicopathological study in the Indian scenario. (24350007)
2013
45
Remission of ulcerated necrobiosis lipoidica diabeticorum after bariatric surgery. (23762652)
2013
46
Hyperkeratotic necrobiosis lipoidica. (23785630)
2013
47
Necrobiotic Granulomatous Tattoo Reaction: Report of an Unusual Case Showing Features of Both Necrobiosis Lipoidica and Granuloma Annulare Patterns. (24335518)
2013
48
Large plaques in a patient with diabetes. Diagnosis: Necrobiosis lipoidica. (24069666)
2013
49
Squamous cell carcinoma arising in ulcerated necrobiosis lipoidica diabeticorum. (24373177)
2013
50
Perforating disseminated necrobiosis lipoidica diabeticorum. (23533835)
2013

Variations for Necrobiosis Lipoidica

About this section

Expression for genes affiliated with Necrobiosis Lipoidica

About this section
Search GEO for disease gene expression data for Necrobiosis Lipoidica.

Pathways for genes affiliated with Necrobiosis Lipoidica

About this section

Pathways related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.3SLC2A1, TNFRSF1B
29.3SLC2A1, TNFRSF1B
3
Show member pathways
9.1INS, SLC2A1
49.1INS, SLC2A1
59.1INS, SLC2A1

GO Terms for genes affiliated with Necrobiosis Lipoidica

About this section

Biological processes related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:00069539.7CD163, INS
2glucose transportGO:00157589.6INS, SLC2A1
3positive regulation of DNA replicationGO:00457409.2GLI1, INS

Sources for Necrobiosis Lipoidica

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet