MCID: NCR002
MIFTS: 36

Necrobiosis Lipoidica malady

Skin diseases category

Aliases & Classifications for Necrobiosis Lipoidica

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Summaries for Necrobiosis Lipoidica

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Wikipedia:64 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes but... more...

MalaCards based summary: Necrobiosis Lipoidica is related to granuloma annulare and venous insufficiency. An important gene associated with Necrobiosis Lipoidica is GLI1 (GLI family zinc finger 1), and among its related pathways are Pathways in cancer and AMPK Enzyme Complex Pathway. The compounds mannose and pd 98,059 have been mentioned in the context of this disorder. Affiliated tissues include skin, pancreas and kidney, and related mouse phenotypes are embryogenesis and no phenotypic analysis.

Related Diseases for Necrobiosis Lipoidica

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Diseases related to Necrobiosis Lipoidica via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1granuloma annulare11.1
2venous insufficiency10.6
3rheumatoid arthritis10.4
4arthritis10.4
5angiokeratoma10.4
6balanitis10.4
7blindness10.4
8endotheliitis10.4
9ataxia-telangiectasia10.3
10obesity10.3
11common variable immunodeficiency10.3
12cutaneous leishmaniasis10.3
13lymphomatoid granulomatosis10.3
14maturity-onset diabetes of the young10.3
15cellulitis10.3
16dermatitis10.3
17eye disease10.3
18glomerulosclerosis10.3
19histiocytosis10.3
20leishmaniasis10.3
21lupus erythematosus10.3
22psoriasis10.3
23pyoderma10.3
24retinal disease10.3
25retinitis10.3
26scleroderma10.3
27syphilis10.3
28tertiary syphilis10.3
29thyroiditis10.3
30necrobiotic xanthogranuloma10.3
31ataxia10.3
32proteinuria10.3
33discoid lupus erythematosus10.3
34hemangioma10.1SLC2A1, CD163
35pancreatic cancer10.1GLI1, SLC2A1
36brain cancer10.1SLC2A1, GLI1
37sarcoma10.0GLI1, CD163
38stomach cancer10.0SLC2A1, GLI1
39mody, type ii10.0SLC2A1, INS
40microvascular complications of diabetes 510.0INS, SLC2A1
41coronary artery disease10.0INS, CD163
42hypoglycemia10.0INS, SLC2A1
43hyperinsulinism10.0SLC2A1, INS
44galactosemia9.9CD163, INS
45microvascular complications of diabetes 39.9SLC2A1, INS
46metabolic syndrome x9.9SLC2A1, INS
47hyperglycemia9.9INS, SLC2A1
48diabetes mellitus, insulin-dependent9.8INS, SLC2A1
49diabetes mellitus, noninsulin-dependent9.8SLC2A1, INS
50primary hyperoxaluria9.7INS, SLC2A1

Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to necrobiosis lipoidica

Symptoms for Necrobiosis Lipoidica

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Drugs & Therapeutics for Necrobiosis Lipoidica

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Drug clinical trials:

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Search NIH Clinical Center for Necrobiosis Lipoidica

Genetic Tests for Necrobiosis Lipoidica

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Anatomical Context for Necrobiosis Lipoidica

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MalaCards organs/tissues related to Necrobiosis Lipoidica:

31
Skin, Pancreas, Kidney, Endothelial, Neutrophil, Eye, Thyroid, Testes

Animal Models for Necrobiosis Lipoidica or affiliated genes

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MGI Mouse Phenotypes related to Necrobiosis Lipoidica:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.5SLC2A1, GLI1, INS
2MP:00030128.2SLC2A1, GLI1, INS

Publications for Necrobiosis Lipoidica

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Articles related to Necrobiosis Lipoidica:

(show top 50)    (show all 367)
idTitleAuthorsYear
1
Residents'corner February 2014. DeRmpath & Clinic: differential diagnosis in palisading non-infectious granulomas. Diagnosis: Case 1: Granuloma annulare. Case 2: Necrobiosis lipoidica. (24691245)
2014
2
Necrobiosis lipoidica with elastophagocytosis on an unusual location. (24786578)
2014
3
Specific features of a rare form of disseminated necrobiosis lipoidica granuloma annulare type: a case report. (25611281)
2014
4
Necrobiosis lipoidica diabeticorum: necrobiosis lipoidica diabeticorum in a Nigerian from the north. A case report. (24283101)
2013
5
Long-term successful healing of ulcerated necrobiosis lipoidica after topical therapy with becaplermin. (23962308)
2013
6
Treatment of pre-ulcerative necrobiosis lipoidica with infliximab. (21547338)
2011
7
Ulcerative necrobiosis lipoidica successfully treated by vacuum-assisted closure therapy. (21700546)
2011
8
Arcuate plaques of the face and scalp. Atypical necrobiosis lipoidica (ANL) of the face and scalp. (20831607)
2010
9
Significant improvement in ulcerative necrobiosis lipoidica with hydroxychloroquine. (20465710)
2010
10
Necrobiosis lipoidica in monozygotic twins. (18209185)
2008
11
Detection of spirochaetal microorganisms by focus floating microscopy in necrobiosis lipoidica in patients from central Europe. (18462358)
2008
12
Necrobiosis lipoidica. (17544959)
2007
13
Clinical and pathologic manifestations of necrobiosis lipoidica-like skin involvement in sarcoidosis. (18092383)
2007
14
Images in clinical medicine. Necrobiosis lipoidica diabeticorum. (17079756)
2006
15
Successful treatment of necrobiosis lipoidica diabeticorum with photodynamic therapy. (17178979)
2006
16
What is necrobiosis lipoidica? (15879976)
2005
17
Necrobiosis lipoidica diabeticorum. (16206686)
2005
18
Epidermoid carcinoma and perforating necrobiosis lipoidica: a rare association. (16268888)
2005
19
Generalized necrobiosis lipoidica treated with a combination of split-thickness autografting and immunomodulatory therapy. (15533073)
2004
20
Clearance of necrobiosis lipoidica with fumaric acid esters. (14657645)
2003
21
Necrobiosis lipoidica associated with KAPbner's phenomenon in a patient with diabetes. (11236227)
2001
22
Tissue-engineered dermal skin grafting in the treatment of ulcerated necrobiosis lipoidica. (11298110)
2001
23
Persistent ulcerated necrobiosis lipoidica responding to treatment with cyclosporin. (10583126)
1999
24
Necrobiosis lipoidica: treatment by hyperbaric oxygen and local corticosteroids. (9592641)
1998
25
Necrobiosis lipoidica-like skin lesions in systemic sarcoidosis. (9830264)
1998
26
Necrobiosis lipoidica diabeticorum and thyroid disease. (9372361)
1997
27
Necrobiosis lipoidica in a diabetic intravenous drug user. (9341590)
1997
28
Necrobiosis lipoidica mimicking cellulitis. (20944321)
1997
29
Endothelin-1 expression is not altered in necrobiosis lipoidica and granuloma annulare. (8011514)
1994
30
Ulceration in necrobiosis lipoidica--a case report and study. (8403479)
1993
31
Ulcerating necrobiosis lipoidica effectively treated with pentoxifylline. (8440063)
1993
32
Familial non-diabetic necrobiosis lipoidica. (1445090)
1992
33
A new histopathologic feature of necrobiosis lipoidica diabeticorum: lymphoid nodules. (3372792)
1988
34
Pentoxifylline for necrobiosis lipoidica diabeticorum. (3624574)
1987
35
Successful treatment of ulcerated necrobiosis: lipoidica diabeticorum with prostaglandin E1 and skin flap transfer--a case report. (3914497)
1985
36
Squamous cell carcinoma arising in long-standing necrobiosis lipoidica. (3966816)
1985
37
Necrobiosis lipoidica: treatment with porcine dressings, split-thickness skin grafts and pressure garments. A case report and review of treatment modalities. (3904539)
1985
38
Direct immunofluorescence studies in granuloma annulare, necrobiosis lipoidica and granulomatosis disciformis Miescher. (381068)
1979
39
Granuloma annulare, rheumatoid nodules and necrobiosis lipoidica. (884054)
1977
40
Proceedings: Necrobiosis lipoidica diabeticorum disseminata. (4811828)
1974
41
Capillaroscopic changes in the course of necrobiosis lipoidica. (5782165)
1969
42
Atypical forms of necrobiosis lipoidica diabeticorum. A report of three cases. (5905217)
1966
43
Necrobiosis lipoidica granulomatosis. Necrobiosis lipoidica diabeticorum in the nondiabetic. (13742950)
1960
44
Scirrhous Metastasis Simulating Necrobiosis Lipoidica. (19993878)
1956
45
Necrobiosis lipoidica diabeticorum with intercapillary glomerulosclerosis. (14360798)
1955
46
Necrobiosis lipoidica. (13269650)
1955
47
Necrobiosis lipoidica diabeticorum following pyoderma. (18208051)
1948
48
Necrobiosis lipoidica diabeticorum. (18100968)
1948
49
Necrobiosis lipoidica without diabetes. (21065490)
1945
50
Necrobiosis Lipoidica Diabeticorum. (19991166)
1937

Variations for Necrobiosis Lipoidica

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Expression for genes affiliated with Necrobiosis Lipoidica

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Search GEO for disease gene expression data for Necrobiosis Lipoidica.

Pathways for genes affiliated with Necrobiosis Lipoidica

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Compounds for genes affiliated with Necrobiosis Lipoidica

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Compounds related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

(show all 22)
idCompoundScoreTop Affiliating Genes
1mannose449.5SLC2A1, CD163
2pd 98,059449.4SLC2A1, GLI1
3glimepiride44 50 1111.4SLC2A1, INS
4aicar44 24 1111.4SLC2A1, INS
5alpha lipoic acid449.4INS, SLC2A1
6glibenclamide44 28 50 6012.4SLC2A1, INS
72-deoxyglucose44 1110.4SLC2A1, INS
8metformin44 50 1111.3INS, SLC2A1
9olanzapine44 50 28 24 1113.3SLC2A1, INS
10paraffin449.3SLC2A1, CD163
11pioglitazone28 44 50 1112.3INS, SLC2A1
12palmitate449.3INS, SLC2A1
13rosiglitazone28 44 50 24 1113.3SLC2A1, INS
14troglitazone44 28 60 1112.2INS, SLC2A1
15ibmx44 60 2811.2SLC2A1, INS
16rapamycin449.1INS, SLC2A1
17ly294002449.0SLC2A1, INS
18wortmannin448.9INS, SLC2A1
19dexamethasone44 50 28 1111.8SLC2A1, CD163, INS
20phosphatidylinositol448.8SLC2A1, GLI1, INS
21glucose448.8SLC2A1, GLI1, INS
22glycogen44 249.7SLC2A1, INS

GO Terms for genes affiliated with Necrobiosis Lipoidica

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Biological processes related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:00069539.2CD163, INS
2positive regulation of DNA replicationGO:00457409.1GLI1, INS
3energy reserve metabolic processGO:00061129.0SLC2A1, INS
4glucose transportGO:00157588.9INS, SLC2A1
5regulation of insulin secretionGO:00507968.7SLC2A1, INS

Molecular functions related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055158.0SLC2A1, CD163, GLI1, INS

Sources for Necrobiosis Lipoidica

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet