MCID: NCR002
MIFTS: 33

Necrobiosis Lipoidica malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Necrobiosis Lipoidica

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Aliases & Descriptions for Necrobiosis Lipoidica:

Name: Necrobiosis Lipoidica 11 46 13 37 66
 
Necrobiosis Lipoidica Diabeticorum 46 66

Classifications:



External Ids:

Disease Ontology11 DOID:3486
MeSH37 D009335
NCIt43 C34840
ICD1028 L92.1

Summaries for Necrobiosis Lipoidica

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NIH Rare Diseases:46 Necrobiosis lipoidica is a rare skin disorder of collagen degeneration. it is characterized by a rash that occurs on the lower legs. it is more common in women, and there are usually several spots. they are slightly raised shiny red-brown patches. the centers are often yellowish and may develop open sores that are slow to heal. infections can occur but are uncommon. some patients have itching, pain, or abnormal sensations. it usually occurs more often in people with diabetes, in people with a family history of diabetes or a tendency to get diabetes, but can occur in nondiabetic people. about 11% to 65% of patients with necrobiosis lipoidica also have diabetes, but the exact cause is still not known. treatment is difficult. the disease is typically chronic with variable progression and scarring. last updated: 6/6/2016

MalaCards based summary: Necrobiosis Lipoidica, also known as necrobiosis lipoidica diabeticorum, is related to granuloma annulare and venous insufficiency. An important gene associated with Necrobiosis Lipoidica is CD163 (CD163 Molecule), and among its related pathways are IL-3 Signaling Pathway and Adipocytokine signaling pathway. Affiliated tissues include skin, pancreas and endothelial.

Wikipedia:69 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes... more...

Related Diseases for Necrobiosis Lipoidica

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Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to necrobiosis lipoidica

Symptoms for Necrobiosis Lipoidica

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Drugs & Therapeutics for Necrobiosis Lipoidica

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Necrobiosis Lipoidica


Cochrane evidence based reviews: necrobiosis lipoidica

Genetic Tests for Necrobiosis Lipoidica

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Anatomical Context for Necrobiosis Lipoidica

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MalaCards organs/tissues related to Necrobiosis Lipoidica:

34
Skin, Pancreas, Endothelial, Neutrophil, Thyroid, Kidney, Eye

Animal Models for Necrobiosis Lipoidica or affiliated genes

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Publications for Necrobiosis Lipoidica

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Articles related to Necrobiosis Lipoidica:

(show top 50)    (show all 386)
idTitleAuthorsYear
1
Anti-TNFI+ treatment for recalcitrant ulcerative necrobiosis lipoidica diabeticorum: A case report and review of the literature. (26975548)
2016
2
Necrobiosis lipoidica with elastophagocytosis on an unusual location. (24786578)
2014
3
Specific features of a rare form of disseminated necrobiosis lipoidica granuloma annulare type: a case report. (25611281)
2014
4
Long-term successful healing of ulcerated necrobiosis lipoidica after topical therapy with becaplermin. (23962308)
2013
5
Large plaques in a patient with diabetes. Diagnosis: Necrobiosis lipoidica. (24069666)
2013
6
Photodynamic therapy for necrobiosis lipoidica is an unpredictable option: three cases with different results. (24261738)
2013
7
Unsightly rash on shin. Necrobiosis lipoidica diabeticorum. (22482106)
2012
8
Case of necrobiosis lipoidica diabeticorum successfully treated by photodynamic therapy. (21950273)
2012
9
Resolution of long-standing necrobiosis lipoidica diabeticorum (NLD) lesion after restoration of euglycemia following successful pancreas after kidney (PAK) transplantation: a case report. (22099781)
2011
10
Intralesional infliximab in noninfectious cutaneous granulomas: three cases of necrobiosis lipoidica. (21625077)
2011
11
Arcuate plaques of the face and scalp. Atypical necrobiosis lipoidica (ANL) of the face and scalp. (20831607)
2010
12
Significant improvement in ulcerative necrobiosis lipoidica with hydroxychloroquine. (20465710)
2010
13
Necrobiosis lipoidica and cutaneous anaesthesia: immunohistochemical study of neural fibres. (18587710)
2008
14
Dermacase. Necrobiosis lipoidica. (18556491)
2008
15
Clinical and pathologic manifestations of necrobiosis lipoidica-like skin involvement in sarcoidosis. (18092383)
2007
16
Systemic corticosteroids for the outpatient treatment of necrobiosis lipoidica in a diabetic patient. (17671885)
2007
17
Tuberous necrobiosis lipoidica. (17438196)
2007
18
Using a protease-modulating dressing to treat necrobiosis lipoidica diabeticorum. (16521596)
2006
19
Healing of severe ulcerative necrobiosis lipoidica with cyclosporin. (15068460)
2004
20
Clearance of necrobiosis lipoidica with fumaric acid esters. (14657645)
2003
21
Necrobiosis lipoidica: only a minority of patients have diabetes mellitus. (10233223)
1999
22
Necrobiosis lipoidica: treatment by hyperbaric oxygen and local corticosteroids. (9592641)
1998
23
Necrobiosis lipoidica and diabetic control revisited. (8733162)
1996
24
Ulceration in necrobiosis lipoidica--a case report and study. (8403479)
1993
25
Expression of interstitial collagenase, 92-kDa gelatinase, and tissue inhibitor of metalloproteinases-1 in granuloma annulare and necrobiosis lipoidica diabeticorum. (8382717)
1993
26
Familial non-diabetic necrobiosis lipoidica. (1445090)
1992
27
Periorbital necrobiosis lipoidica. (1390543)
1992
28
Rapid healing of ulcerated necrobiosis lipoidica with optimum glycaemic control and seaweed-based dressings. (1760369)
1991
29
Focal endothelial cell degeneration and proliferative endarteritis in trauma-induced early lesions of necrobiosis lipoidica diabeticorum. (1805659)
1991
30
High dose nicotinamide in the treatment of necrobiosis lipoidica. (2969260)
1988
31
Necrobiosis-lipoidica-like skin manifestation in lymphomatoid granulomatosis (Liebow). (3556699)
1987
32
Antithrombotic agents in necrobiosis lipoidica. (2424230)
1986
33
Successful treatment of ulcerated necrobiosis: lipoidica diabeticorum with prostaglandin E1 and skin flap transfer--a case report. (3914497)
1985
34
Squamous cell carcinoma arising in long-standing necrobiosis lipoidica. (3966816)
1985
35
Sweat gland disturbances in granuloma annulare and necrobiosis lipoidica. (6860561)
1983
36
Treatment with benzoyl peroxide of ulcers on legs within lesions of necrobiosis lipoidica diabeticorum. (701591)
1978
37
Granuloma annulare, rheumatoid nodules and necrobiosis lipoidica. (884054)
1977
38
Systemic sarcoidosis with necrobiosis lipoidica-like scalp lesions. (70934)
1977
39
Capillaroscopic changes in the course of necrobiosis lipoidica. (5782165)
1969
40
Atypical forms of necrobiosis lipoidica diabeticorum. A report of three cases. (5905217)
1966
41
Necrobiosis lipoidica diabeticorum. A clinical and pathological investigation of 171 cases. (5910868)
1966
42
Sarcoidosis with skin lesions simulating necrobiosis lipoidica. (13453416)
1957
43
Scirrhous Metastasis Simulating Necrobiosis Lipoidica. (19993878)
1956
44
Necrobiosis lipoidica diabeticorum with intercapillary glomerulosclerosis. (14360798)
1955
45
Necrobiosis lipoidica (diabeticorum?) a histologic study and comparison with granuloma annulare. (18113617)
1949
46
Necrobiosis lipoidica diabeticorum following pyoderma. (18208051)
1948
47
Necrobiosis lipoidica diabeticorum. (18100968)
1948
48
Necrobiosis lipoidica. (18905000)
1948
49
Necrobiosis lipoidica without diabetes. (21065490)
1945
50
Necrobiosis Lipoidica Diabeticorum. (19991166)
1937

Variations for Necrobiosis Lipoidica

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Expression for genes affiliated with Necrobiosis Lipoidica

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Search GEO for disease gene expression data for Necrobiosis Lipoidica.

Pathways for genes affiliated with Necrobiosis Lipoidica

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Pathways related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3SLC2A1, TNFRSF1B
29.3SLC2A1, TNFRSF1B
3
Show member pathways
9.3SLC2A1, TNFRSF1B
49.1INS, SLC2A1

GO Terms for genes affiliated with Necrobiosis Lipoidica

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Biological processes related to Necrobiosis Lipoidica according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glucose transportGO:00157589.5INS, SLC2A1
2acute-phase responseGO:00069539.4CD163, INS
3positive regulation of MAPK cascadeGO:00434109.0INS, TNFRSF1B
4positive regulation of DNA replicationGO:00457408.9GLI1, INS

Sources for Necrobiosis Lipoidica

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet