MCID: NCR002
MIFTS: 39

Necrobiosis Lipoidica malady

Skin diseases category

Summaries for Necrobiosis Lipoidica

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63Wikipedia, 32MalaCards
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Wikipedia:63 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes but... more...

MalaCards: Necrobiosis Lipoidica is related to proteinuria and retinal disease. An important gene associated with Necrobiosis Lipoidica is GLI1 (GLI family zinc finger 1), and among its related pathways are AMPK Enzyme Complex Pathway and Insulin secretion. The compounds glimepiride and aicar have been mentioned in the context of this disorder. Affiliated tissues include skin, pancreas and kidney, and related mouse phenotypes are embryogenesis and no phenotypic analysis.

Aliases & Classifications for Necrobiosis Lipoidica

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Necrobiosis Lipoidica

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to necrobiosis lipoidica

Clinical Features for Necrobiosis Lipoidica

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Drugs & Therapeutics for Necrobiosis Lipoidica

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Necrobiosis Lipoidica

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Genetic Tests for Necrobiosis Lipoidica

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Anatomical Context for Necrobiosis Lipoidica

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32MalaCards
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MalaCards organs/tissues related to Necrobiosis Lipoidica:

32
Skin, Pancreas, Kidney, Endothelial, Eye, Thyroid, Testes

Animal Models for Necrobiosis Lipoidica or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Necrobiosis Lipoidica:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.5SLC2A1, INS, GLI1
2MP:00030128.2SLC2A1, INS, GLI1

Publications for Necrobiosis Lipoidica

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50PubMed
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Articles related to Necrobiosis Lipoidica:

(show top 50)    (show all 354)
idTitleAuthorsYear
1
Photodynamic therapy for necrobiosis lipoidica is an unpredictable option: three cases with different results. (24261738)
2013
2
Necrobiosis lipoidica. (24392215)
2013
3
Squamous cell carcinoma arising in ulcerated necrobiosis lipoidica diabeticorum. (24373177)
2013
4
Unsightly rash on shin. Necrobiosis lipoidica diabeticorum. (22482106)
2012
5
Case of necrobiosis lipoidica diabeticorum successfully treated by photodynamic therapy. (21950273)
2012
6
Necrobiosis lipoidica diabeticorum: A case-based review of literature. (22837927)
2012
7
Images in clinical medicine. Necrobiosis lipoidica diabeticorum. (22738100)
2012
8
Arcuate plaques of the face and scalp. Atypical necrobiosis lipoidica (ANL) of the face and scalp. (20831607)
2010
9
Dramatic response of chronic ulcerating necrobiosis lipoidica to ultraviolet A1 phototherapy. (21140992)
2010
10
Treatment of necrobiosis lipoidica with etanercept and adalimumab. (20040262)
2009
11
Necrobiosis lipoidica in monozygotic twins. (18209185)
2008
12
Perforating necrobiosis lipoidica in a girl with type 1 diabetes mellitus: a new case reported. (18718195)
2008
13
Periorbital necrobiosis lipoidica diabeticorum: case report. (17914605)
2008
14
Clinical and pathologic manifestations of necrobiosis lipoidica-like skin involvement in sarcoidosis. (18092383)
2007
15
Familial necrobiosis lipoidica not associated with diabetes. (18328220)
2007
16
Photo quiz. Case 9. Necrobiosis lipoidica diabeticorum. (18189021)
2007
17
Images in clinical medicine. Necrobiosis lipoidica diabeticorum. (17079756)
2006
18
UVA1 phototherapy for treatment of necrobiosis lipoidica. (16487100)
2006
19
What is necrobiosis lipoidica? (15879976)
2005
20
Healing of severe ulcerative necrobiosis lipoidica with cyclosporin. (15068460)
2004
21
Necrobiosis lipoidica diabeticorum: response to pentoxiphylline. (14759079)
2003
22
Necrobiosis lipoidica associated with KAPbner's phenomenon in a patient with diabetes. (11236227)
2001
23
Successful treatment of ulcerated necrobiosis lipoidica with mycophenolate mofetil. (11028876)
2000
24
Severe disabling KAPebnerizing ulcerated necrobiosis lipoidica successfully managed with topical PUVA. (10971363)
2000
25
Healing of chronic leg ulcers in diabetic necrobiosis lipoidica with local granulocyte-macrophage colony stimulating factor treatment. (10432176)
1999
26
Necrobiosis lipoidica mimicking cellulitis. (20944321)
1997
27
Perforating elastosis in necrobiosis lipoidica diabeticorum. (8726715)
1996
28
Increased natural autoantibody activity to cytoskeleton proteins in sera from patients with necrobiosis lipoidica, with or without insulin-dependent diabetes mellitus. (7578889)
1995
29
Familial non-diabetic necrobiosis lipoidica. (1445090)
1992
30
Periorbital necrobiosis lipoidica. (1390543)
1992
31
Diffuse necrobiosis lipoidica diabeticorum. (1516382)
1992
32
Epidermal dendritic S100 positive cells in necrobiosis lipoidica and granuloma annulare. (2265092)
1990
33
The cutaneous immunopathology of necrobiosis lipoidica diabeticorum. (3046497)
1988
34
Immunofluorescence, necrobiosis lipoidica, and blood vessels. Fluorescent lights in the tunnels. (3046500)
1988
35
Increased plasma fibronectin in diabetes mellitus, necrobiosis lipoidica and widespread granuloma annulare. (6733961)
1984
36
HLA antigens and necrobiosis lipoidica diabeticorum--a comparison between insulin-dependent diabetics with and without necrobiosis. (6581479)
1983
37
Aspirin iin the management of necrobiosis lipoidica. (6179354)
1982
38
Necrobiosis lipoidica and granuloma annulare. Simultaneous occurrence in a patient. (7065670)
1982
39
Non-diabetic necrobiosis lipoidica. Hitherto unrecognized papulonecrotic, nodulo-ulcerative and familial forms of the disease. (7466484)
1981
40
A randomized double blind comparison of an aspirin dipyridamole combination versus a placebo in the treatment of necrobiosis lipoidica. (6167117)
1981
41
An unusual example of necrobiosis lipoidica affecting the face. (7370465)
1980
42
Aspirin and dipyridamole ineffective in treatment of necrobiosis lipoidica. (7001236)
1980
43
Atypical necrobiosis lipoidica of the face. (78648)
1978
44
Diabetes mellitus, sarcoidosis,?necrobiosis lipoidica. (5818027)
1969
45
Atypical (annular) necrobiosis lipoidica of the face and scalp. A report of the clinical and histological features of 7 cases. (6033000)
1967
46
Necrobiosis lipoidica diabeticorum. (5957504)
1966
47
NECROBIOSIS LIPOIDICA: A HISTOPATHOLOGICAL AND HISTOCHEMICAL STUDY. (14319916)
1965
48
Case of necrobiosis lipoidica diabeticorum. (18153195)
1949
49
Multiple Minute Fibro-angiomata of Face and Ears (Pringle's Disease, Darier's Type).A ? MorphA9a with Tuberculous Histology:A ? Necrobiosis Lipoidica. Mucin in Granuloma Annulare. Angiokeratoma. A Form of "Mamillated Tongue". Sarcoidosis. (20917468)
1945
50
Necrobiosis Lipoidica Diabeticorum (Urbach-Oppenheim). (19989758)
1934

Genetic Variations for Necrobiosis Lipoidica

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Expression for genes affiliated with Necrobiosis Lipoidica

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Necrobiosis Lipoidica

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Pathways for genes affiliated with Necrobiosis Lipoidica

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51QIAGEN, 29KEGG, 53Reactome, 12EMD Millipore
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Pathways related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1SLC2A1, INS
29.1SLC2A1, INS
39.1INS, SLC2A1
4
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9.1SLC2A1, INS
59.1SLC2A1, INS

Compounds for genes affiliated with Necrobiosis Lipoidica

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1glimepiride44 49 1111.4SLC2A1, INS
2aicar44 11 2411.4SLC2A1, INS
3alpha lipoic acid449.4SLC2A1, INS
4olanzapine49 44 28 11 2413.4INS, SLC2A1
5glibenclamide44 28 49 5912.4SLC2A1, INS
62-deoxyglucose44 1110.3SLC2A1, INS
7metformin44 49 1111.3SLC2A1, INS
8pioglitazone44 49 28 1112.2SLC2A1, INS
9palmitate449.1INS, SLC2A1
10ibmx44 28 5911.1SLC2A1, INS
11glucose449.1SLC2A1, GLI1
12rosiglitazone44 49 28 11 2413.0SLC2A1, INS
13troglitazone44 28 59 1111.8SLC2A1, INS
14phosphatidylinositol448.7GLI1, INS, SLC2A1

GO Terms for genes affiliated with Necrobiosis Lipoidica

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16Gene Ontology
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Biological processes related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of DNA replicationGO:0457409.3INS, GLI1
2energy reserve metabolic processGO:0061129.1SLC2A1, INS
3glucose transportGO:0157589.0SLC2A1, INS
4regulation of insulin secretionGO:0507968.8SLC2A1, INS

Products for genes affiliated with Necrobiosis Lipoidica

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  • Antibodies
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Sources for Necrobiosis Lipoidica

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet