MCID: NCR002
MIFTS: 39

Necrobiosis Lipoidica malady

Skin diseases category

Summaries for Necrobiosis Lipoidica

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63Wikipedia, 32MalaCards
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Wikipedia:63 Necrobiosis lipoidica is a necrotising skin condition that usually occurs in patients with diabetes but... more...

MalaCards: Necrobiosis Lipoidica is related to proteinuria and retinal disease. An important gene associated with Necrobiosis Lipoidica is GLI1 (GLI family zinc finger 1), and among its related pathways are AMPK Enzyme Complex Pathway and Insulin secretion. The compounds glimepiride and aicar have been mentioned in the context of this disorder. Affiliated tissues include skin, pancreas and kidney, and related mouse phenotypes are embryogenesis and no phenotypic analysis.

Aliases & Classifications for Necrobiosis Lipoidica

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8Disease Ontology, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 25ICD10
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Related Diseases for Necrobiosis Lipoidica

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Necrobiosis Lipoidica:



Diseases related to necrobiosis lipoidica

Clinical Features for Necrobiosis Lipoidica

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Drugs & Therapeutics for Necrobiosis Lipoidica

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Necrobiosis Lipoidica

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Anatomical Context for Necrobiosis Lipoidica

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32MalaCards
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MalaCards organs/tissues related to Necrobiosis Lipoidica:

32
Skin, Pancreas, Kidney, Endothelial, Eye, Thyroid, Testes

Animal Models for Necrobiosis Lipoidica or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Necrobiosis Lipoidica:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.5SLC2A1, INS, GLI1
2MP:00030128.2SLC2A1, INS, GLI1

Publications for Necrobiosis Lipoidica

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50PubMed
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Articles related to Necrobiosis Lipoidica:

(show top 50)    (show all 354)
idTitleAuthorsYear
1
Long-term successful healing of ulcerated necrobiosis lipoidica after topical therapy with becaplermin. (23962308)
2013
2
A diabetic child with lesions over his legs. Necrobiosis lipoidica diabeticorum. (23841546)
2013
3
Necrobiotic Granulomatous Tattoo Reaction: Report of an Unusual Case Showing Features of Both Necrobiosis Lipoidica and Granuloma Annulare Patterns. (24335518)
2013
4
Treatment of ulcerated necrobiosis lipoidica with ovine forestomach matrix. (24159661)
2013
5
Dermoscopy of necrobiosis lipoidica and granuloma annulare. (23797090)
2013
6
Dermatoscopy of early-onset necrobiosis lipoidica. (22421129)
2012
7
Simultaneous occurrence of ulcerated necrobiosis lipoidica and granuloma annulare in a patient: case report. (22147045)
2011
8
Necrobiosis lipoidica of the glans penis. (21103831)
2011
9
Necrobiosis lipoidica of the scrotum. (21233076)
2011
10
Necrobiosis lipoidica and inflammatory eye disease. (21369527)
2011
11
Necrobiosis lipoidica therapy with biologicals: an ulcerated case responding to etanercept and a review of the literature. (20805688)
2010
12
Photodynamic therapy of necrobiosis lipoidica--a multicenter study of 18 patients. (19060464)
2009
13
Does pancreas transplant in diabetic patients affect the evolution of necrobiosis lipoidica? (19702981)
2009
14
A case of perforating necrobiosis lipoidica in an African American female. (18718194)
2008
15
Necrobiosis lipoidica: an important cutaneous manifestation of diabetes that may respond to antiplatelet therapy. (18996827)
2008
16
Necrobiosis lipoidica. (17544959)
2007
17
Tuberous necrobiosis lipoidica. (17438196)
2007
18
Healing of chronic necrobiosis lipoidica lesions in a type 1 diabetic patient after pancreas-kidney transplantation: a case report. (17505163)
2007
19
Successful treatment of necrobiosis lipoidica diabeticorum with photodynamic therapy. (17178979)
2006
20
Long-term results of topical PUVA in necrobiosis lipoidica. (16309486)
2006
21
Ulcerated necrobiosis lipoidica: a combined treatment approach with dermatosurgery and PUVA. (15866853)
2003
22
Necrobiosis lipoidica diabeticorum. (12387963)
2002
23
Necrobiosis lipoidica in a 9-year-old girl with new-onset type II diabetes mellitus. (11576406)
2001
24
Squamous cell carcinoma developing in necrobiosis lipoidica. (11437865)
2001
25
Necrobiosis lipoidica. Indolent plaques may signal diabetes. (11265368)
2001
26
Necrobiosis lipoidica diabeticorum treated with the pulsed dye laser. (12006191)
2001
27
The prevalence of necrobiosis lipoidica diabeticorum in children with type 1 diabetes. (10583092)
1999
28
Interference of dapsone in HbA1c monitoring of a type I diabetic patient with necrobiosis lipoidica. (7821184)
1994
29
Focal endothelial cell degeneration and proliferative endarteritis in trauma-induced early lesions of necrobiosis lipoidica diabeticorum. (1805659)
1991
30
Increased activity of serum amine oxidases in granuloma annulare, necrobiosis lipoidica and diabetes. (2885024)
1987
31
Treatment of necrobiosis lipoidica with low-dose acetylsalicylic acid. A randomized double-blind trial. (2411079)
1985
32
Direct immunofluorescence studies in granuloma annulare, necrobiosis lipoidica and granulomatosis disciformis Miescher. (381068)
1979
33
Systemic sarcoidosis with necrobiosis lipoidica-like scalp lesions. (70934)
1977
34
Necrobiosis lipoidica diabeticorum. (5548408)
1971
35
Atypical forms of necrobiosis lipoidica diabeticorum. A report of three cases. (5905217)
1966
36
Hydrocortisone in necrobiosis lipoidica diabeticorum. (13479664)
1957
37
Necrobiosis lipoidica diabeticorum with intercapillary glomerulosclerosis. (14360798)
1955
38
Necrobiosis lipoidica. (13269650)
1955
39
Necrobiosis lipoidica diabeticorum of the scalp. (13194655)
1954
40
Necrobiosis lipoidica diabeticorum. (12996058)
1952
41
A case for diagnosis: tertiary syphilis? Necrobiosis lipoidica? (14789251)
1951
42
Necrobiosis lipoidica diabeticorum resembling deep type granuloma annulare (two cases). (14853974)
1951
43
Two cases of necrobiosis lipoidica diabeticorum. (14789433)
1950
44
Necrobiosis lipoidica diabeticorum very difficult to differentiate from lymphogranulomatosis of Schaumann (illustration). (14789440)
1950
45
Necrobiosis lipoidica diabeticorum. (18100968)
1948
46
Necrobiosis lipoidica diabeticorum. (20287996)
1947
47
Necrobiosis lipoidica (diabeticorum?). (21026333)
1946
48
Necrobiosis lipoidica without diabetes. (21065490)
1945
49
Necrobiosis lipoidica diabeticorum. (21005913)
1945
50
Multiple Minute Fibro-angiomata of Face and Ears (Pringle's Disease, Darier's Type). ? Morphoea with Tuberculous Histology: ? Necrobiosis Lipoidica. Mucin in Granuloma Annulare. Angiokeratoma. A Form of "Mamillated Tongue". Sarcoidosis. (19993071)
1945

Genetic Variations for Necrobiosis Lipoidica

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Expression for genes affiliated with Necrobiosis Lipoidica

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Necrobiosis Lipoidica

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Pathways for genes affiliated with Necrobiosis Lipoidica

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51QIAGEN, 29KEGG, 53Reactome, 12EMD Millipore
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Pathways related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1SLC2A1, INS
29.1SLC2A1, INS
39.1INS, SLC2A1
4
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9.1SLC2A1, INS
59.1SLC2A1, INS

Compounds for genes affiliated with Necrobiosis Lipoidica

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

(show all 14)
idCompoundScoreTop Affiliating Genes
1glimepiride44 49 1111.4SLC2A1, INS
2aicar44 11 2411.4SLC2A1, INS
3alpha lipoic acid449.4SLC2A1, INS
4olanzapine49 44 28 11 2413.4INS, SLC2A1
5glibenclamide44 28 49 5912.4SLC2A1, INS
62-deoxyglucose44 1110.3SLC2A1, INS
7metformin44 49 1111.3SLC2A1, INS
8pioglitazone44 49 28 1112.2SLC2A1, INS
9palmitate449.1INS, SLC2A1
10ibmx44 28 5911.1SLC2A1, INS
11glucose449.1SLC2A1, GLI1
12rosiglitazone44 49 28 11 2413.0SLC2A1, INS
13troglitazone44 28 59 1111.8SLC2A1, INS
14phosphatidylinositol448.7GLI1, INS, SLC2A1

GO Terms for genes affiliated with Necrobiosis Lipoidica

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16Gene Ontology
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Biological processes related to Necrobiosis Lipoidica according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of DNA replicationGO:0457409.3INS, GLI1
2energy reserve metabolic processGO:0061129.1SLC2A1, INS
3glucose transportGO:0157589.0SLC2A1, INS
4regulation of insulin secretionGO:0507968.8SLC2A1, INS

Products for genes affiliated with Necrobiosis Lipoidica

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Sources for Necrobiosis Lipoidica

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet