MCID: NCR007
MIFTS: 44

Necrotizing Fasciitis malady

Rare diseases category

Summaries for Necrotizing Fasciitis

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Sources:
44NIH Rare Diseases, 4CDC, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Necrotizing fasciitis is a serious bacterial infection of the skin, subcutaneous tissue (tissue just beneath the skin) and fascia. the infection can be sudden and fast-spreading. the bacteria involved enters the body through an external injury and attacks the surrounding tissues, eventually causing them to die. early signs include flu-like symptoms and redness or pain around the infection site, followed by very high fever, severe pain, swelling and blistering. if the infection is not treated promptly, it may cause multiple organ failure and death. treatment typically includes intravenous antibiotics; surgery to remove infected and dead tissue; hyperbaric oxygen therapy; and intravenous immune globulin therapy. last updated: 5/16/2012

MalaCards: Necrotizing Fasciitis is related to gas gangrene and diabetes mellitus. An important gene associated with Necrotizing Fasciitis is SPEG (SPEG complex locus), and among its related pathways are Complement and coagulation cascades and Type II diabetes mellitus. The compounds monoethylglycinexylidide and ximelagatran have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and breast.

CDC:4 Group A Streptococcus (group A strep, GAS) bacteria can live in a person's nose and throat. The bacteria are spread through contact with droplets from an infected person's cough or sneeze. If you touch your mouth, nose, or eyes after touching something that has these droplets on it, you may become ill. If you drink from the same glass or eat from the same plate as the sick person, you could also become ill. It is also possible for group A strep bacteria to spread from contact with sores from a group A strep skin infection. More

Wikipedia:66 Necrotizing fasciitis (/?n?kr??ta?z?? ?f more...

Aliases & Classifications for Necrotizing Fasciitis

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9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 63UMLS, 28ICD9CM, 36MeSH, 59SNOMED-CT, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

necrotizing fasciitis 9 44 11 63


External Ids:

Disease Ontology9 DOID:9602
ICD9CM28 728.86
MeSH36 D019115
SNOMED-CT59 186428007, 52486002
NCIt41 C84916
ICD1026 M72.6

Related Diseases for Necrotizing Fasciitis

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to necrotizing fasciitis

Symptoms for Necrotizing Fasciitis

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Drugs & Therapeutics for Necrotizing Fasciitis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Necrotizing Fasciitis

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Anatomical Context for Necrotizing Fasciitis

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34MalaCards
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MalaCards organs/tissues related to Necrotizing Fasciitis:

34
Skin, Eye, Breast, Colon, Liver, Kidney, Bone, Spinal cord, Tonsil, Pancreas, Bone marrow, Small intestine, Heart, Myeloid

Animal Models for Necrotizing Fasciitis or affiliated genes

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Publications for Necrotizing Fasciitis

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53PubMed
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Articles related to Necrotizing Fasciitis:

(show top 50)    (show all 540)
idTitleAuthorsYear
1
Fulminant necrotizing fasciitis caused by Serratia marcescens in an immunosuppressed host. (22640271)
2014
2
Temporizing surgical management improves outcome in patients with Vibrio necrotizing fasciitis complicated with septic shock on admission. (24138809)
2013
3
Facial necrotizing fasciitis. (23859680)
2013
4
Necrotizing fasciitis: contribution and limitations of diagnostic imaging. (23043899)
2013
5
Necrotizing fasciitis in patients who underwent renal transplantation. (23972528)
2013
6
Early necrotizing fasciitis or isolated subcutaneous emphysema? (23358045)
2013
7
Necrotizing fasciitis involving the chest and abdominal wall caused by Raoultella planticola. (22423899)
2012
8
Necrotizing fasciitis caused by a primary appendicocutaneous fistula. (22318638)
2012
9
Cervicofacial necrotizing fasciitis following periodontal abscess. (22782044)
2012
10
Group a streptococcus necrotizing fasciitis of the eyelid: a case report of good outcome with medical management. (21415799)
2012
11
Klebsiella pneumoniae cervical necrotizing fasciitis originating as an abscess. (22809880)
2012
12
Life-threatening necrotizing fasciitis due to 'bath salts' injection. (22229605)
2012
13
Factors associated with the mediastinal spread of cervical necrotizing fasciitis. (22115335)
2012
14
Atypical presentation of abdominal group A streptococcal-necrotizing fasciitis after pessary removal. (21789662)
2012
15
Necrotizing Fasciitis of the Cervical Region following Extravasation Injury. (23251188)
2012
16
Diagnosis and management of necrotizing fasciitis. (21410101)
2011
17
Unusual case of necrotizing fasciitis caused by Vibrio cholerae O137. (21159937)
2011
18
Transfer status: a risk factor for mortality in patients with necrotizing fasciitis. (21783216)
2011
19
Necrotizing fasciitis: an unusual presentation. (23024950)
2011
20
Necrotizing fasciitis: early sonographic diagnosis. (21480291)
2011
21
Necrotizing fasciitis of the head and neck. (20848400)
2010
22
Adapting a Vacuum Assisted Closure dressing to challenging wounds: negative pressure treatment for perineal necrotizing fasciitis with rectal prolapse in a newborn affected by acute myeloid leukaemia. (20406723)
2010
23
Molecular pathogenesis of necrotizing fasciitis. (19737105)
2010
24
Necrotizing fasciitis due to Pseudomonas aeruginosa in immuno-compromised children. (20486189)
2010
25
Long-term outcomes of patients with necrotizing fasciitis. (20061842)
2010
26
Necrotizing fasciitis due to acute perforated appendicitis: case report. (18226875)
2010
27
Extended retroperitoneal necrotizing fasciitis with genital involvement, resembling fournier gangrene. (20583955)
2010
28
Necrotizing fasciitis in southeast Taiwan: clinical features, microbiology, and prognosis. (18922719)
2009
29
The epidemiology of necrotizing fasciitis including factors associated with death and amputation. (19351432)
2009
30
Immune cell subsets in necrotizing fasciitis: an immunohistochemical analysis. (19529958)
2009
31
Necrotizing fasciitis in a patient treated with etanercept for dermatomyositis. (18795294)
2009
32
Necrotizing fasciitis and myonecrosis "synergistic necrotizing cellulitis" caused by Bacillus cereus. (19583692)
2009
33
Recurrent thigh abscess with necrotizing fasciitis from a retained transobturator sling segment. (19110187)
2009
34
Cervico-facial necrotizing fasciitis. (19207484)
2009
35
Necrotizing fasciitis. Case report. (19093634)
2008
36
Community-acquired methicillin-resistant Staphylococcus aureus emerging as an important cause of necrotizing fasciitis. (18399783)
2008
37
Severe necrotizing fasciitis complicating odontogenic nfection: a case report. (18605530)
2008
38
A case of necrotizing fasciitis due to Streptococcus agalactiae, Arcanobacterium haemolyticum, and Finegoldia magna in a dog-bitten patient with diabetes. (18594170)
2008
39
Case cluster of necrotizing fasciitis and cellulitis associated with vein sclerotherapy. (18258105)
2008
40
A fatal case of necrotizing fasciitis due to bacterial translocation of Klebsiella oxytoca. (18297453)
2008
41
Necrotizing fasciitis in an HIV-infected patient. (18583805)
2008
42
Staging of necrotizing fasciitis based on the evolving cutaneous features. (17910710)
2007
43
Cervical necrotizing fasciitis in an uncontrolled type II diabetic patient. (18603881)
2006
44
A pilot study of cytokine levels and white blood cell counts in the diagnosis of necrotizing fasciitis. (16338511)
2006
45
Massive soft tissue infections: necrotizing fasciitis and purpura fulminans. (15715517)
2005
46
Streptococcal necrotizing fasciitis with toxic shock syndrome following cervical adenitis. (15302155)
2004
47
Conventional open surgery versus percutaneous catheter drainage in the treatment of cervical necrotizing fasciitis and descending necrotizing mediastinitis. (15149988)
2004
48
Post-varicella epiglottitis and necrotizing fasciitis. (10617750)
2000
49
Report of 2 fatal cases of adult necrotizing fasciitis and toxic shock syndrome caused by Streptococcus agalactiae. (11049806)
2000
50
Surgical implications of necrotizing fasciitis in children with chickenpox. (8863250)
1996

Variations for Necrotizing Fasciitis

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Expression for genes affiliated with Necrotizing Fasciitis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Necrotizing Fasciitis

Search GEO for disease gene expression data for Necrotizing Fasciitis.

Pathways for genes affiliated with Necrotizing Fasciitis

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51PathCards, 31KEGG, 39NCBI BioSystems Database, 52PharmGKB
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Pathways related to Necrotizing Fasciitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.8CD46, F5
2
Show member pathways
9.2INS, PIK3C2A

Compounds for genes affiliated with Necrotizing Fasciitis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 3BitterDB, 25HMDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Necrotizing Fasciitis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1monoethylglycinexylidide4610.1GPT, F5
2ximelagatran46 1211.1F5, GPT
3acarbose46 1211.0INS, GPT
4desogestrel46 1211.0INS, F5
5hind iii469.8CD46, F5
6nash469.8INS, GPT
7metformin46 52 1211.8GPT, INS, F5
8policosanol469.7PIK3C2A, GPT
9penicillin469.7F5, IGHE
10ezetimibe46 1210.7GPT, INS
11alpha-hydroxybutyrate469.7PIK3C2A, GPT
12p-007469.7GPT, PIK3C2A
13acetaminophen46 3 52 25 1213.6F5, GPT, IGHE
14protamine469.6IGHE, F5, INS
15cyproteroneacetate469.6INS, F5
16tacrolimus46 52 1211.5INS, F5, GPT
17cyclophosphamide46 52 1211.5F5, CD46, IGHE
18hydrocortisone46 3 62 1212.5F5, INS, IGHE
19succinylcholine46 52 30 1212.4IGHE, PIK3C2A
20warfarin46 52 25 1212.3F5, GPT, PIK3C2A
21malondialdehyde469.3F5, PIK3C2A, GPT
22gemfibrozil30 46 1211.3INS, GPT, PIK3C2A
23bezafibrate46 30 1211.3GPT, INS, PIK3C2A
24fenofibrate46 52 1211.3PIK3C2A, GPT, INS
25vitamin-e469.3PIK3C2A, GPT, F5
26atorvastatin46 52 30 25 1213.3F5, PIK3C2A, GPT
27urea46 25 1211.3F5, GPT, PIK3C2A
28cocaine46 1210.3PIK3C2A, GPT, F5
29simvastatin46 52 62 30 25 1214.2PIK3C2A, GPT, F5
30ivig469.2IGHE, PIK3C2A, GPT
31prednisolone46 30 1211.1GPT, IGHE, PIK3C2A
32choline46 25 1211.1PIK3C2A, IGHE, GPT
33uric acid46 2510.0PIK3C2A, GPT, INS, F5
34glycerol46 25 1210.9INS, IGHE, PIK3C2A
35fibrinogen468.9INS, GPT, PIK3C2A, F5
36glycogen46 259.9PIK3C2A, GPT, F5, INS
37pge1468.9F5, GPT, IGHE, PIK3C2A
38cyclosporin a46 30 6210.8CD46, GPT, PIK3C2A, IGHE
39heroin46 52 1210.8IGHE, PIK3C2A
40thyroxine46 259.8PIK3C2A, IGHE, GPT, INS
41methotrexate52 46 1210.8IGHE, GPT, PIK3C2A
42epinephrine46 25 1210.8F5, INS, IGHE, PIK3C2A
43aspartate468.7GPT, PIK3C2A, F5, IGHE
44cholesterol46 30 25 1211.7INS, GPT, F5, PIK3C2A
45testosterone46 62 25 1211.6IGHE, PIK3C2A, INS, F5
46lactate468.4F5, INS, GPT, IGHE, PIK3C2A
47creatinine468.4GPT, PIK3C2A, IGHE, F5, INS
48arginine468.4IGHE, GPT, F5, PIK3C2A, INS
49glutamate468.4PIK3C2A, IGHE, GPT, INS, F5
50alanine468.1INS, IGHE, GPT, PIK3C2A, CD46, F5

GO Terms for genes affiliated with Necrotizing Fasciitis

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Products for genes affiliated with Necrotizing Fasciitis

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Sources for Necrotizing Fasciitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet