MCID: NCR007
MIFTS: 43

Necrotizing Fasciitis malady

Rare diseases category

Summaries for Necrotizing Fasciitis

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NIH Rare Diseases:42 Necrotizing fasciitis is a serious bacterial infection of the skin, subcutaneous tissue (tissue just beneath the skin) and fascia. the infection can be sudden and fast-spreading. the bacteria involved enters the body through an external injury and attacks the surrounding tissues, eventually causing them to die. early signs include flu-like symptoms and redness or pain around the infection site, followed by very high fever, severe pain, swelling and blistering. if the infection is not treated promptly, it may cause multiple organ failure and death. treatment typically includes intravenous antibiotics; surgery to remove infected and dead tissue; hyperbaric oxygen therapy; and intravenous immune globulin therapy. last updated: 5/16/2012

MalaCards based summary: Necrotizing Fasciitis is related to gas gangrene and diabetic ketoacidosis. An important gene associated with Necrotizing Fasciitis is SPEG (SPEG complex locus), and among its related pathways are Complement and coagulation cascades and Type II diabetes mellitus. The compounds monoethylglycinexylidide and ximelagatran have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and colon.

Wikipedia:64 Necrotizing fasciitis (/?n?kr??ta?z?? ?f more...

Aliases & Classifications for Necrotizing Fasciitis

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Necrotizing Fasciitis, Aliases & Descriptions:

Name: Necrotizing Fasciitis 9 42 11 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:9602
ICD9CM28 728.86
MeSH34 D019115
SNOMED-CT56 186428007, 52486002
NCIt39 C84916
ICD1026 M72.6

Related Diseases for Necrotizing Fasciitis

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Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to necrotizing fasciitis

Symptoms for Necrotizing Fasciitis

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Drugs & Therapeutics for Necrotizing Fasciitis

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Drug clinical trials:

Search ClinicalTrials for Necrotizing Fasciitis

Search NIH Clinical Center for Necrotizing Fasciitis

Genetic Tests for Necrotizing Fasciitis

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Anatomical Context for Necrotizing Fasciitis

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MalaCards organs/tissues related to Necrotizing Fasciitis:

32
Skin, Breast, Colon, Liver, Kidney, Bone, Spinal cord, Tonsil, Bone marrow, Heart, Small intestine, Pancreas, Myeloid, Neutrophil

Animal Models for Necrotizing Fasciitis or affiliated genes

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Publications for Necrotizing Fasciitis

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Articles related to Necrotizing Fasciitis:

(show top 50)    (show all 571)
idTitleAuthorsYear
1
A fatal case of multidrug resistant acinetobacter necrotizing fasciitis: the changing scary face of nosocomial infection. (25349748)
2014
2
Fulminant necrotizing fasciitis caused by Serratia marcescens in an immunosuppressed host. (22640271)
2014
3
Temporizing surgical management improves outcome in patients with Vibrio necrotizing fasciitis complicated with septic shock on admission. (24138809)
2013
4
Facial necrotizing fasciitis. (23859680)
2013
5
Necrotizing fasciitis: contribution and limitations of diagnostic imaging. (23043899)
2013
6
Necrotizing fasciitis in patients who underwent renal transplantation. (23972528)
2013
7
Early necrotizing fasciitis or isolated subcutaneous emphysema? (23358045)
2013
8
Necrotizing fasciitis involving the chest and abdominal wall caused by Raoultella planticola. (22423899)
2012
9
Necrotizing fasciitis caused by a primary appendicocutaneous fistula. (22318638)
2012
10
Cervicofacial necrotizing fasciitis following periodontal abscess. (22782044)
2012
11
Group a streptococcus necrotizing fasciitis of the eyelid: a case report of good outcome with medical management. (21415799)
2012
12
Klebsiella pneumoniae cervical necrotizing fasciitis originating as an abscess. (22809880)
2012
13
Life-threatening necrotizing fasciitis due to 'bath salts' injection. (22229605)
2012
14
Factors associated with the mediastinal spread of cervical necrotizing fasciitis. (22115335)
2012
15
Atypical presentation of abdominal group A streptococcal-necrotizing fasciitis after pessary removal. (21789662)
2012
16
Necrotizing Fasciitis of the Cervical Region following Extravasation Injury. (23251188)
2012
17
Diagnosis and management of necrotizing fasciitis. (21410101)
2011
18
Unusual case of necrotizing fasciitis caused by Vibrio cholerae O137. (21159937)
2011
19
Transfer status: a risk factor for mortality in patients with necrotizing fasciitis. (21783216)
2011
20
Necrotizing fasciitis: an unusual presentation. (23024950)
2011
21
Necrotizing fasciitis: early sonographic diagnosis. (21480291)
2011
22
Necrotizing fasciitis of the head and neck. (20848400)
2010
23
Adapting a Vacuum Assisted Closure dressing to challenging wounds: negative pressure treatment for perineal necrotizing fasciitis with rectal prolapse in a newborn affected by acute myeloid leukaemia. (20406723)
2010
24
Molecular pathogenesis of necrotizing fasciitis. (19737105)
2010
25
Necrotizing fasciitis due to Pseudomonas aeruginosa in immuno-compromised children. (20486189)
2010
26
Long-term outcomes of patients with necrotizing fasciitis. (20061842)
2010
27
Necrotizing fasciitis due to acute perforated appendicitis: case report. (18226875)
2010
28
Extended retroperitoneal necrotizing fasciitis with genital involvement, resembling fournier gangrene. (20583955)
2010
29
Necrotizing fasciitis in southeast Taiwan: clinical features, microbiology, and prognosis. (18922719)
2009
30
The epidemiology of necrotizing fasciitis including factors associated with death and amputation. (19351432)
2009
31
Immune cell subsets in necrotizing fasciitis: an immunohistochemical analysis. (19529958)
2009
32
Necrotizing fasciitis in a patient treated with etanercept for dermatomyositis. (18795294)
2009
33
Necrotizing fasciitis and myonecrosis "synergistic necrotizing cellulitis" caused by Bacillus cereus. (19583692)
2009
34
Recurrent thigh abscess with necrotizing fasciitis from a retained transobturator sling segment. (19110187)
2009
35
Cervico-facial necrotizing fasciitis. (19207484)
2009
36
Necrotizing fasciitis. Case report. (19093634)
2008
37
Community-acquired methicillin-resistant Staphylococcus aureus emerging as an important cause of necrotizing fasciitis. (18399783)
2008
38
Severe necrotizing fasciitis complicating odontogenic nfection: a case report. (18605530)
2008
39
A case of necrotizing fasciitis due to Streptococcus agalactiae, Arcanobacterium haemolyticum, and Finegoldia magna in a dog-bitten patient with diabetes. (18594170)
2008
40
Case cluster of necrotizing fasciitis and cellulitis associated with vein sclerotherapy. (18258105)
2008
41
A fatal case of necrotizing fasciitis due to bacterial translocation of Klebsiella oxytoca. (18297453)
2008
42
Necrotizing fasciitis in an HIV-infected patient. (18583805)
2008
43
Cervical necrotizing fasciitis in an uncontrolled type II diabetic patient. (18603881)
2006
44
A pilot study of cytokine levels and white blood cell counts in the diagnosis of necrotizing fasciitis. (16338511)
2006
45
Massive soft tissue infections: necrotizing fasciitis and purpura fulminans. (15715517)
2005
46
Streptococcal necrotizing fasciitis with toxic shock syndrome following cervical adenitis. (15302155)
2004
47
Conventional open surgery versus percutaneous catheter drainage in the treatment of cervical necrotizing fasciitis and descending necrotizing mediastinitis. (15149988)
2004
48
Post-varicella epiglottitis and necrotizing fasciitis. (10617750)
2000
49
Report of 2 fatal cases of adult necrotizing fasciitis and toxic shock syndrome caused by Streptococcus agalactiae. (11049806)
2000
50
Surgical implications of necrotizing fasciitis in children with chickenpox. (8863250)
1996

Variations for Necrotizing Fasciitis

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Expression for genes affiliated with Necrotizing Fasciitis

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Expression patterns in normal tissues for genes affiliated with Necrotizing Fasciitis

Search GEO for disease gene expression data for Necrotizing Fasciitis.

Pathways for genes affiliated with Necrotizing Fasciitis

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Pathways related to Necrotizing Fasciitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.8CD46, F5
2
Show member pathways
9.2INS, PIK3C2A

Compounds for genes affiliated with Necrotizing Fasciitis

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Compounds related to Necrotizing Fasciitis according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1monoethylglycinexylidide4410.1GPT, F5
2ximelagatran44 1211.1F5, GPT
3acarbose44 1211.0INS, GPT
4desogestrel44 1211.0INS, F5
5hind iii449.8CD46, F5
6nash449.8INS, GPT
7metformin44 50 1211.8GPT, INS, F5
8policosanol449.7PIK3C2A, GPT
9penicillin449.7F5, IGHE
10ezetimibe44 1210.7GPT, INS
11alpha-hydroxybutyrate449.7PIK3C2A, GPT
12p-007449.7GPT, PIK3C2A
13acetaminophen44 3 50 25 1213.6F5, GPT, IGHE
14protamine449.6IGHE, F5, INS
15cyproteroneacetate449.6INS, F5
16tacrolimus44 50 1211.5INS, F5, GPT
17cyclophosphamide44 50 1211.5F5, CD46, IGHE
18hydrocortisone44 3 60 1212.5F5, INS, IGHE
19succinylcholine44 50 29 1212.4IGHE, PIK3C2A
20warfarin44 50 25 1212.3F5, GPT, PIK3C2A
21malondialdehyde449.3F5, PIK3C2A, GPT
22gemfibrozil29 44 1211.3INS, GPT, PIK3C2A
23bezafibrate44 29 1211.3GPT, INS, PIK3C2A
24fenofibrate44 50 1211.3PIK3C2A, GPT, INS
25vitamin-e449.3PIK3C2A, GPT, F5
26atorvastatin44 50 29 25 1213.3F5, PIK3C2A, GPT
27urea44 25 1211.3F5, GPT, PIK3C2A
28cocaine44 1210.3PIK3C2A, GPT, F5
29simvastatin44 50 60 29 25 1214.2PIK3C2A, GPT, F5
30ivig449.2IGHE, PIK3C2A, GPT
31prednisolone44 29 1211.1GPT, IGHE, PIK3C2A
32choline44 25 1211.1PIK3C2A, IGHE, GPT
33uric acid44 2510.0PIK3C2A, GPT, INS, F5
34glycerol44 25 1210.9INS, IGHE, PIK3C2A
35fibrinogen448.9INS, GPT, PIK3C2A, F5
36glycogen44 259.9PIK3C2A, GPT, F5, INS
37pge1448.9F5, GPT, IGHE, PIK3C2A
38cyclosporin a44 29 6010.8CD46, GPT, PIK3C2A, IGHE
39heroin44 50 1210.8IGHE, PIK3C2A
40thyroxine44 259.8PIK3C2A, IGHE, GPT, INS
41methotrexate50 44 1210.8IGHE, GPT, PIK3C2A
42epinephrine44 25 1210.8F5, INS, IGHE, PIK3C2A
43aspartate448.7GPT, PIK3C2A, F5, IGHE
44cholesterol44 29 25 1211.7INS, GPT, F5, PIK3C2A
45testosterone44 60 25 1211.6IGHE, PIK3C2A, INS, F5
46lactate448.4F5, INS, GPT, IGHE, PIK3C2A
47creatinine448.4GPT, PIK3C2A, IGHE, F5, INS
48arginine448.4IGHE, GPT, F5, PIK3C2A, INS
49glutamate448.4PIK3C2A, IGHE, GPT, INS, F5
50alanine448.1INS, IGHE, GPT, PIK3C2A, CD46, F5

GO Terms for genes affiliated with Necrotizing Fasciitis

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Products for genes affiliated with Necrotizing Fasciitis

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Sources for Necrotizing Fasciitis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet