Aliases & Classifications for Necrotizing Fasciitis

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Aliases & Descriptions for Necrotizing Fasciitis:

Name: Necrotizing Fasciitis 11 48 2 13 68
 
Fasciitis, Necrotizing 39

Classifications:



External Ids:

Disease Ontology11 DOID:9602
ICD1030 M72.6
ICD9CM32 728.86
SNOMED-CT62 186428007, 52486002
MeSH39 D019115
NCIt45 C84916

Summaries for Necrotizing Fasciitis

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NIH Rare Diseases:48 Necrotizing fasciitis is a serious infection of the skin, the tissue just beneath the skin (subcutaneous tissue), and the tissue that covers internal organs (fascia). Necrotizing fasciitis can be caused by several different types of bacteria, and the infection can arise suddenly and spread quickly. Early signs include flu-like symptoms and redness and pain around the infection site. A prompt diagnosis and treatment are essential. If the infection is not treated promptly, it can lead to multiple organ failure and death. Treatment typically includes intravenous (IV) antibiotics and surgery to remove infected and dead tissue. Last updated: 4/12/2016

MalaCards based summary: Necrotizing Fasciitis, also known as fasciitis, necrotizing, is related to pharyngitis and systemic lupus erythematosus, and has symptoms including spasm and generalized muscle weakness. An important gene associated with Necrotizing Fasciitis is CD46 (CD46 Molecule), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and African trypanosomiasis. Affiliated tissues include skin, eye and colon, and related mouse phenotype cardiovascular system.

CDC:2 Group A Streptococcus (group A strep) is a bacterium that can cause many different infections, including strep throat, scarlet fever, impetigo, and others. The bacteria live in the nose and throat. When someone who is infected coughs or sneezes, the bacteria travel in small droplets of water called respiratory droplets. One of the ways you can get sick is if you breathe in those droplets or if you touch something that has the droplets on it and then touch your mouth, nose, or eyes.

Wikipedia:71 Necrotising fasciitis (NF), commonly known as flesh-eating disease, is an infection that results in the... more...

Related Diseases for Necrotizing Fasciitis

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Diseases related to Necrotizing Fasciitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1pharyngitis29.8IL1RN, IL2
2systemic lupus erythematosus29.8IL18, IL2, IL6, LTA
3bullous pemphigoid29.8IL6, MYOM2
4rheumatoid arthritis29.2CXCL8, IL18, IL1RN, IL2, IL6
5fournier gangrene11.4
6fasciitis11.0
7prostate calculus10.6CXCL8, IL18
8cervical incompetence10.6CXCL8, IL18
9corneal deposit10.6CXCL8, IL6
10tarsal tunnel syndrome10.6CXCL8, IL6
11anterior dislocation of lens10.5CXCL8, IL6
12retinal vascular disease10.5CXCL8, IL6
13benign adult familial myoclonic epilepsy10.5CXCL8, IL6
14acute posterior multifocal placoid pigment epitheliopathy10.5CXCL8, IL6
15infancy electroclinical syndrome10.5CXCL8, IL6
16arteriolosclerosis10.5IL18, IL6
17silo filler's disease10.5IL18, IL1RN
18skin disease10.5CXCL8, IL6
19pasteurellosis10.5CXCL8, IL6
20sterility due to immotile flagella10.5IL18, IL6
21subglottis neoplasm10.5CXCL8, IL6
22osteogenesis imperfecta, type x10.5CXCL8, IL6
23syphilitic encephalitis10.5IL18, IL6
24hemometra10.5IL6, LTA
25gasserian ganglion meningioma10.5CXCL8, IL6
26marchiafava bignami disease10.5CXCL8, IL6
27inflammatory spondylopathy10.5CXCL8, IL6
28renal cell carcinoma 410.5IL18, IL6
29carbon baby syndrome10.5IL1RN, IL6
30atrophic vulva10.5IL1RN, IL6
31shwartzman phenomenon10.5CXCL8, IL2
32ocular cancer10.5CXCL8, IL6
33cervicitis10.5
34prostate leiomyosarcoma10.5IL1RN, IL6
35orbital lymphangioma10.4CXCL8, IL6
36human monocytic ehrlichiosis10.4IL18, IL6
37fallopian tube disease10.4CXCL8, IL2
38paraneoplastic polyneuropathy10.4CXCL8, IL6
39kallmann syndrome 410.4IL2, LTA
40addison's disease10.4CXCL8, IL2
41tonsillar fossa cancer10.4CXCL8, IL6
42splenic manifestation of prolymphocytic leukemia10.4IL2, IL6
43mechanical lagophthalmos10.4CXCL8, IL6
44cinca syndrome10.4IL18, IL1RN
45benign fibrous mesothelioma10.4CXCL8, IL2
46abducens nerve neoplasm10.4CXCL8, IL6
47primary biliary cirrhosis10.4IL6, LTA
48vertebral artery insufficiency10.3IL18, IL6
49qualitative platelet defect10.3CXCL8, IL18, IL6
50scrotum melanoma10.3CXCL8, IL18, IL6

Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to necrotizing fasciitis

Symptoms & Phenotypes for Necrotizing Fasciitis

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UMLS symptoms related to Necrotizing Fasciitis:


spasm, generalized muscle weakness

MGI Mouse Phenotypes related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.0CCNF, CD46, IL18, IL1RN, IL2, IL6

Drugs & Therapeutics for Necrotizing Fasciitis

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Drugs for Necrotizing Fasciitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunoglobulins, IntravenousPhase 2324
2AntibodiesPhase 26045
3ImmunoglobulinsPhase 26045
4Rho(D) Immune GlobulinPhase 2317
5gamma-GlobulinsPhase 2317
6Immunoglobulin GPhase 2265
7
Carbon monoxideapprovedPhase 1116630-08-0281
Synonyms:
CO
 
Carbon monoxide
Carboneum oxygenisatum
carbon(II) oxide
8
Daptomycinapproved, investigational86103060-53-316129629
Synonyms:
103060-53-3
AKOS005146218
C12013
C72H101N17O26
CHEBI:600103
CHEMBL508162
Cidecin
Cubicin
Cubicin (TN)
D01080
DAPTOMYCIN
Dapcin
Daptomicina
Daptomicina [Spanish]
Daptomycin (JAN/USAN/INN)
Daptomycin [USAN:INN:BAN]
Daptomycine
 
Daptomycine [French]
Daptomycinum
Daptomycinum [Latin]
Deptomycin
LS-171846
LY 146032
LY-146032
LY146032
MK-3009
MolPort-003-846-138
N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-ox
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
UNII-NWQ5N31VKK
daptomycin
nchembio.184-comp5
9
Azithromycinapproved33383905-01-555185, 53477736, 447043
Synonyms:
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
1-Oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-,(2R-(2R*,3S*
121470-24-4
75199_FLUKA
83905-01-5
9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A
AC-16014
AC1L9KEG
Aritromicina
Azasite
Azenil
Azifast
Azigram
Azimakrol
Azithramycine
Azithromycin
Azithromycin & Tumor Necrosis Factor
Azithromycin (AIDS Initiative)
Azithromycin (anhydrous)
Azithromycin Dihydrate
Azithromycin Monohydrate
Azithromycin Sterile
Azithromycin dihydrate
Azithromycin plus Tumor Necrosis Factor
Azithromycine
Azithromycine [French]
Azithromycinum
Azithromycinum [Latin]
Azitrocin
Azitromax
Azitromicina
Azitromicina [Spanish]
Azitromin
Azythromycin
BIDD:GT0792
BRN 5387583
BSPBio_002285
Bio-0676
C38H72N2O12
CCRIS 1961
CHEBI:2955
CHEMBL529
CID447043
CP-62993
CP62,993
CPD000471864
DCH3
DRG-0104
 
DivK1c_000233
HMS1922G12
HMS2094M11
HMS500L15
HSDB 7205
Hemomycin
IDI1_000233
KBio1_000233
KBio2_000787
KBio2_003355
KBio2_005923
KBio3_001505
KBioGR_000731
KBioSS_000787
LS-1834
MLS001055353
MLS001066331
MLS001201763
MLS001304005
MLS001332499
MLS001332500
Misultina
MolPort-002-507-426
N,N-Dimethyl-4-amino-benzaldehyde
NCGC00090753-01
NCGC00090753-02
NINDS_000233
NSC643732
SAM002589961
SMR000471864
SPBio_001544
SPECTRUM1503679
Spectrum2_001582
Spectrum3_000653
Spectrum4_000186
Spectrum5_001867
Spectrum_000307
Sumamed
Tromix
UNII-JTE4MNN1MD
XZ-450
Z-Pak
ZIT
Zentavion
Zithromac
Zithromax
Zithromax IV
Zithromycin
Zitromax
Zitromax Avium 600
Zmas
Zmax
azithromycin
10Antibiotics, Antitubercular6972
11Anti-Bacterial Agents10884
12Anti-Infective Agents21402

Interventional clinical trials:

(show all 19)
idNameStatusNCT IDPhase
1Negative Pressure Wound Therapy With the Engenex™-Pump and Bio-Dome™ Dressing, an EvaluationRecruitingNCT01107821Phase 4
2Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue InfectionsRecruitingNCT02469857Phase 3
3Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled TrialCompletedNCT02111161Phase 2
4A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic ChildrenCompletedNCT00670891Phase 1
5Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus InfectionsUnknown statusNCT01731483
6Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing FasciitisCompletedNCT01739959
7Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological FeaturesCompletedNCT01139112
8Outcome and Related Factors of Necrotizing Fasciitis of the LimbCompletedNCT00538577
9Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue InfectionsCompletedNCT00261807
10Biomarkers in Patients With Flesh-eating Bacterial InfectionsCompletedNCT02180906
11Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital TractCompletedNCT00299663
12Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean InfectionCompletedNCT01235546
13Factors Associated With Complications of Cervical Necrotizing FasciitisRecruitingNCT02847234
14Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs).RecruitingNCT01790698
15Severe Soft Tissue Infections: Perspectives of Patients and Significant OthersRecruitingNCT02169128
16Genetic Susceptibility to Severe Streptococcal InfectionsRecruitingNCT01911572
17Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen TreatmentRecruitingNCT02501382
18Hyperglycemia in Surgical InfectionsTerminatedNCT00353275
19Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA)WithdrawnNCT00896402

Search NIH Clinical Center for Necrotizing Fasciitis


Cochrane evidence based reviews: fasciitis, necrotizing

Genetic Tests for Necrotizing Fasciitis

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Anatomical Context for Necrotizing Fasciitis

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MalaCards organs/tissues related to Necrotizing Fasciitis:

36
Skin, Eye, Colon, Liver, Kidney, Bone, Tonsil

Publications for Necrotizing Fasciitis

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Articles related to Necrotizing Fasciitis:

(show top 50)    (show all 674)
idTitleAuthorsYear
1
Necrotizing Fasciitis in Aesthetic Surgery: A Review of the Literature. (28062962)
2017
2
Concurrent external and intraluminal vacuum-assisted closure in head and neck necrotizing fasciitis. (28084021)
2017
3
Impact of Intravenous Immunoglobulin on Survival in Necrotizing Fasciitis with Vasopressor-dependent Shock: A Propensity-Score Matched Analysis from 130 US Hospitals. (28034881)
2016
4
A case of labio-facial necrotizing fasciitis complicating acne. (27107717)
2016
5
The diagnosis you wish you had never operated on: Pyoderma gangrenosum misdiagnosed as necrotizing fasciitis-a case report. (27875063)
2016
6
Salvage therapy with intravenous fosfomycin plus ceftriaxone for necrotizing fasciitis caused by penicillin-nonsusceptible Streptococcus pneumoniae. (28082065)
2016
7
Necrotizing Fasciitis of the Lower Extremity Caused by Serratia marcescens A Case Report. (27031553)
2016
8
Diagnosis and Treatment of Pediatric Necrotizing Fasciitis: A Systematic Review of the Literature. (27380058)
2016
9
It's Not Always What It Seems: Necrotizing Fasciitis Mimicking Angioedema. (27072731)
2016
10
Bilateral Necrotizing Fasciitis of the Foot Associated with Group B Streptococcus. (27790114)
2016
11
Necrotizing fasciitis associated with systemic lupus erythematosus in a child. (27626093)
2016
12
Case Report of Necrotizing Fasciitis Associated with Streptococcus pneumoniae. (27366176)
2016
13
Necrotizing fasciitis in a patient receiving tocilizumab for rheumatoid arthritis - Case report. (28041910)
2016
14
Necrotizing fasciitis of anterior abdominal wall following cesarean section in a low-risk patient. (27402541)
2016
15
Triple diagnostics for early detection of ambivalent necrotizing fasciitis. (27766113)
2016
16
Klebsiella pneumoniae necrotizing fasciitis. (27658424)
2016
17
First case report of Nocardia brasiliensis infection causing necrotizing fasciitis in an immunocompetent patient. (27117138)
2016
18
Pediatric Necrotizing Fasciitis: Restitutio Ad Integrum after Early Diagnosis and Aggressive Surgical Treatment. (28035291)
2016
19
Necrotizing fasciitis associated with systemic lupus erythematosus in a child. (27559515)
2016
20
Two non-otic cases of POM-1 metallo-I^-lactamase-producing Pseudomonas otitidis infection: Necrotizing fasciitis and pan-peritonitis. (27835844)
2016
21
Odontogenic cervical necrotizing fasciitis, etiological aspects. (27022806)
2016
22
Evaluation of Factors Associated with Death in Patients with Necrotizing Fasciitis of the Abdominal Wall. (27929925)
2016
23
Synchronous multifocal necrotizing fasciitis prognostic factors: a retrospective case series study in a single center. (27778190)
2016
24
Complete Genome Sequence of Staphylococcus aureus MCRF184, a Necrotizing Fasciitis-Causing Methicillin-Sensitive Sequence Type 45 Staphylococcus Strain. (27174283)
2016
25
Cervical Necrotizing Fasciitis Caused by Dental Extraction. (27375905)
2016
26
Isolated digital necrotizing fasciitis: an unusual presentation. (27881796)
2016
27
Necrotizing Fasciitis as a Complication of a Continuous Sciatic Nerve Catheter Using the Lateral Popliteal Approach. (27662064)
2016
28
Pyoderma gangrenosum and necrotizing fasciitis-like opportunistic invasive cutaneous fungal infection. (27126743)
2016
29
Necrotizing Fasciitis Presenting as an Itchy Thigh. (27579187)
2016
30
Necrotic fasciitis of the lateral muscle group of the thigh following outside-in transobturatory tape procedure. (27918157)
2016
31
Fatal Fulminant Retroperitoneal Necrotizing Fasciitis Caused by Streptococcus viridans. (27097613)
2016
32
Assessment of Administrative Medical Claims Data for Public Health Surveillance of Invasive Group A Streptococcal Necrotizing Fasciitis in Tennessee. (27453600)
2016
33
The Free-style Gluteal Perforator Flap in the Thinning and Delay Process for Perineal Reconstruction After Necrotizing Fasciitis. (27434419)
2016
34
Ludwig's angina complicated by fatal cervicofascial and mediastinal necrotizing fasciitis. (27077024)
2016
35
Comment on: "Cervical Necrotizing Fasciitis-The Value of the Laboratory Risk Indicator for Necrotizing Fasciitis Score as an Indicative Parameter". (26963076)
2016
36
Pattern and predictors of mortality in necrotizing fasciitis patients in a single tertiary hospital. (27508002)
2016
37
Sequential necrotizing fasciitis caused by the monomicrobial pathogens Streptococcus equisimilis and extended-spectrum beta-lactamase-producing Escherichia coli. (26912298)
2016
38
A Necrotizing Fasciitis Fake Out on Point-of-Care Ultrasound-Watch the Shadow. (27743718)
2016
39
AA rare case of necrotizing fasciitis caused by Vibrio cholerae O8 in an immunocompetent patient. (27604649)
2016
40
Instillation Therapy for the Treatment of Necrotizing Fasciitis: A Case Study. (28083461)
2016
41
Rare Complication of Stomas: Peristomal Necrotizing Fasciitis. (28054929)
2016
42
Sonographic Findings in Necrotizing Fasciitis: Two Ends of the Spectrum. (27582527)
2016
43
A 10-Year Review of Necrotizing Fasciitis in the Pediatric Population: Delays to Diagnosis and Management. (27663964)
2016
44
Necrotizing Fasciitis: A Life-threatening Complication of Intraoperative Electromyography. (26973803)
2016
45
Necrotizing fasciitis due to Vibrio cholerae non-O1/non-O139 after exposure to Austrian bathing sites. (26825075)
2016
46
A case report of necrotizing fasciitis of the abdominal wall: A rare, life-threatening complication of a common disease process. (27794239)
2016
47
Ascending Facial Necrotizing Fasciitis in a Patient Taking a Bisphosphonate. (27639154)
2016
48
Nonodontogenic Cervical Necrotizing Fasciitis Caused by Sialadenitis. (27822398)
2016
49
What's new in emergencies, trauma and shock? The tortuous path in the management of necrotizing fasciitis: Is early surgical intervention critical? (26957818)
2016
50
Flow-through Instillation of Hypochlorous Acid in the Treatment of Necrotizing Fasciitis. (26891136)
2016

Variations for Necrotizing Fasciitis

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Expression for genes affiliated with Necrotizing Fasciitis

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Search GEO for disease gene expression data for Necrotizing Fasciitis.

Pathways for genes affiliated with Necrotizing Fasciitis

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Pathways related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 24)
idSuper pathwaysScoreTop Affiliating Genes
19.9CXCL8, IL6
29.8IL18, IL6
39.6IL2, IL6
49.6IL18, IL2
59.5IL2, LTA
6
Show member pathways
9.5CXCL8, IL18, IL6
7
Show member pathways
9.5CXCL8, IL18, IL6
89.5CXCL8, IL18, IL6
99.5CXCL8, IL18, IL6
109.5CXCL8, IL18, IL6
119.4CXCL8, IL1RN, IL6
129.3CXCL8, IL2, IL6
139.3CXCL8, IL2, IL6
149.3CXCL8, IL2, IL6
15
Show member pathways
9.2CXCL8, IL2, LTA
169.2IL18, IL2, LTA
17
Show member pathways
9.1CXCL8, IL18, IL1RN, IL6
18
Show member pathways
9.0CXCL8, IL18, IL2, IL6
19
Show member pathways
8.9IL18, IL2, IL6, LTA
20
Show member pathways
8.9IL18, IL2, IL6, LTA
218.6CXCL8, IL18, IL2, IL6, LTA
22
Show member pathways
8.6CXCL8, IL18, IL2, IL6, LTA
23
Show member pathways
8.6CXCL8, IL18, IL2, IL6, LTA
24
Show member pathways
8.3CD46, CXCL8, IL18, IL2, IL6, LTA

GO Terms for genes affiliated with Necrotizing Fasciitis

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Cellular components related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.1CXCL8, IL18, IL1RN, IL2, IL6, LTA

Biological processes related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immunoglobulin secretionGO:005102410.2IL2, IL6
2natural killer cell activationGO:003010110.2IL18, IL2
3positive regulation of activated T cell proliferationGO:004210410.2IL18, IL2
4positive regulation of regulatory T cell differentiationGO:004559110.2CD46, IL2
5positive regulation of interleukin-17 productionGO:003274010.1IL18, IL2
6positive regulation of interferon-gamma productionGO:00327299.7IL18, IL2, LTA
7positive regulation of tissue remodelingGO:00341059.6IL18, IL2
8positive regulation of T cell proliferationGO:00421029.5CD46, IL2, IL6
9immune responseGO:00069559.4CXCL8, IL18, IL1RN, IL2

Molecular functions related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.4IL18, IL1RN, IL2, IL6, LTA

Sources for Necrotizing Fasciitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet