MCID: NCR007
MIFTS: 38

Necrotizing Fasciitis malady

Rare diseases category

Aliases & Classifications for Necrotizing Fasciitis

About this section

Necrotizing Fasciitis, Aliases & Descriptions:

Name: Necrotizing Fasciitis 9 41 11 3 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:9602
NCIt38 C84916
ICD9CM27 728.86
SNOMED-CT55 186428007, 52486002
MeSH33 D019115
ICD1025 M72.6

Summaries for Necrotizing Fasciitis

About this section


NIH Rare Diseases:41 Necrotizing fasciitis is a serious bacterial infection of the skin, subcutaneous tissue (tissue just beneath the skin) and fascia. the infection can be sudden and fast-spreading. the bacteria involved enters the body through an external injury and attacks the surrounding tissues, eventually causing them to die. early signs include flu-like symptoms and redness or pain around the infection site, followed by very high fever, severe pain, swelling and blistering. if the infection is not treated promptly, it may cause multiple organ failure and death. treatment typically includes intravenous antibiotics; surgery to remove infected and dead tissue; hyperbaric oxygen therapy; and intravenous immune globulin therapy. last updated: 5/16/2012

MalaCards based summary: Necrotizing Fasciitis is related to gas gangrene and diabetic ketoacidosis. An important gene associated with Necrotizing Fasciitis is SPEG (SPEG complex locus), and among its related pathways are Complement and coagulation cascades and Type II diabetes mellitus. The compounds monoethylglycinexylidide and ximelagatran have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and breast.

CDC:3 Group A Streptococcus (group A strep, GAS) bacteria can live in a person's nose and throat. The bacteria are spread through contact with droplets from an infected person's cough or sneeze. If you touch your mouth, nose, or eyes after touching something that has these droplets on it, you may become ill. If you drink from the same glass or eat from the same plate as the sick person, you could also become ill. It is also possible for group A strep bacteria to spread from contact with sores from a group A strep skin infection.

Wikipedia:63 Necrotizing fasciitis (/?n?kr??ta?z?? ?f more...

Related Diseases for Necrotizing Fasciitis

About this section

Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to necrotizing fasciitis

Symptoms for Necrotizing Fasciitis

About this section

Drugs & Therapeutics for Necrotizing Fasciitis

About this section

Drug clinical trials:

Search ClinicalTrials for Necrotizing Fasciitis

Search NIH Clinical Center for Necrotizing Fasciitis

Genetic Tests for Necrotizing Fasciitis

About this section

Anatomical Context for Necrotizing Fasciitis

About this section

MalaCards organs/tissues related to Necrotizing Fasciitis:

31
Skin, Eye, Breast, Colon, Liver, Kidney, Bone, Spinal cord, Tonsil, Bone marrow, Heart, Small intestine, Pancreas, Myeloid, Neutrophil

Animal Models for Necrotizing Fasciitis or affiliated genes

About this section

Publications for Necrotizing Fasciitis

About this section

Articles related to Necrotizing Fasciitis:

(show top 50)    (show all 596)
idTitleAuthorsYear
1
Necrotizing fasciitis in patients with head and neck cancer. (25721060)
2015
2
A practitioner's guide to necrotizing fasciitis. (25774815)
2015
3
A fatal case of multidrug resistant acinetobacter necrotizing fasciitis: the changing scary face of nosocomial infection. (25349748)
2014
4
Fulminant necrotizing fasciitis caused by Serratia marcescens in an immunosuppressed host. (22640271)
2014
5
Temporizing surgical management improves outcome in patients with Vibrio necrotizing fasciitis complicated with septic shock on admission. (24138809)
2013
6
Facial necrotizing fasciitis. (23859680)
2013
7
Necrotizing fasciitis: contribution and limitations of diagnostic imaging. (23043899)
2013
8
Necrotizing fasciitis in patients who underwent renal transplantation. (23972528)
2013
9
Necrotizing fasciitis involving the chest and abdominal wall caused by Raoultella planticola. (22423899)
2012
10
Necrotizing fasciitis caused by a primary appendicocutaneous fistula. (22318638)
2012
11
Cervicofacial necrotizing fasciitis following periodontal abscess. (22782044)
2012
12
Group a streptococcus necrotizing fasciitis of the eyelid: a case report of good outcome with medical management. (21415799)
2012
13
Klebsiella pneumoniae cervical necrotizing fasciitis originating as an abscess. (22809880)
2012
14
Life-threatening necrotizing fasciitis due to 'bath salts' injection. (22229605)
2012
15
Factors associated with the mediastinal spread of cervical necrotizing fasciitis. (22115335)
2012
16
Atypical presentation of abdominal group A streptococcal-necrotizing fasciitis after pessary removal. (21789662)
2012
17
Necrotizing Fasciitis of the Cervical Region following Extravasation Injury. (23251188)
2012
18
Diagnosis and management of necrotizing fasciitis. (21410101)
2011
19
Unusual case of necrotizing fasciitis caused by Vibrio cholerae O137. (21159937)
2011
20
Transfer status: a risk factor for mortality in patients with necrotizing fasciitis. (21783216)
2011
21
Necrotizing fasciitis: an unusual presentation. (23024950)
2011
22
Necrotizing fasciitis: early sonographic diagnosis. (21480291)
2011
23
Necrotizing fasciitis of the head and neck. (20848400)
2010
24
Adapting a Vacuum Assisted Closure dressing to challenging wounds: negative pressure treatment for perineal necrotizing fasciitis with rectal prolapse in a newborn affected by acute myeloid leukaemia. (20406723)
2010
25
Molecular pathogenesis of necrotizing fasciitis. (19737105)
2010
26
Necrotizing fasciitis due to Pseudomonas aeruginosa in immuno-compromised children. (20486189)
2010
27
Long-term outcomes of patients with necrotizing fasciitis. (20061842)
2010
28
Necrotizing fasciitis due to acute perforated appendicitis: case report. (18226875)
2010
29
Extended retroperitoneal necrotizing fasciitis with genital involvement, resembling fournier gangrene. (20583955)
2010
30
Necrotizing fasciitis in southeast Taiwan: clinical features, microbiology, and prognosis. (18922719)
2009
31
The epidemiology of necrotizing fasciitis including factors associated with death and amputation. (19351432)
2009
32
Immune cell subsets in necrotizing fasciitis: an immunohistochemical analysis. (19529958)
2009
33
Necrotizing fasciitis in a patient treated with etanercept for dermatomyositis. (18795294)
2009
34
Necrotizing fasciitis and myonecrosis "synergistic necrotizing cellulitis" caused by Bacillus cereus. (19583692)
2009
35
Recurrent thigh abscess with necrotizing fasciitis from a retained transobturator sling segment. (19110187)
2009
36
Cervico-facial necrotizing fasciitis. (19207484)
2009
37
Necrotizing fasciitis. Case report. (19093634)
2008
38
Community-acquired methicillin-resistant Staphylococcus aureus emerging as an important cause of necrotizing fasciitis. (18399783)
2008
39
Severe necrotizing fasciitis complicating odontogenic nfection: a case report. (18605530)
2008
40
A case of necrotizing fasciitis due to Streptococcus agalactiae, Arcanobacterium haemolyticum, and Finegoldia magna in a dog-bitten patient with diabetes. (18594170)
2008
41
Case cluster of necrotizing fasciitis and cellulitis associated with vein sclerotherapy. (18258105)
2008
42
Necrotizing fasciitis in an HIV-infected patient. (18583805)
2008
43
Cervical necrotizing fasciitis in an uncontrolled type II diabetic patient. (18603881)
2006
44
A pilot study of cytokine levels and white blood cell counts in the diagnosis of necrotizing fasciitis. (16338511)
2006
45
Massive soft tissue infections: necrotizing fasciitis and purpura fulminans. (15715517)
2005
46
Streptococcal necrotizing fasciitis with toxic shock syndrome following cervical adenitis. (15302155)
2004
47
Conventional open surgery versus percutaneous catheter drainage in the treatment of cervical necrotizing fasciitis and descending necrotizing mediastinitis. (15149988)
2004
48
Post-varicella epiglottitis and necrotizing fasciitis. (10617750)
2000
49
Report of 2 fatal cases of adult necrotizing fasciitis and toxic shock syndrome caused by Streptococcus agalactiae. (11049806)
2000
50
Surgical implications of necrotizing fasciitis in children with chickenpox. (8863250)
1996

Variations for Necrotizing Fasciitis

About this section

Expression for genes affiliated with Necrotizing Fasciitis

About this section
Search GEO for disease gene expression data for Necrotizing Fasciitis.

Pathways for genes affiliated with Necrotizing Fasciitis

About this section

Pathways related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.8CD46, F5
2
Show member pathways
9.2INS, PIK3C2A

Compounds for genes affiliated with Necrotizing Fasciitis

About this section

Compounds related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1monoethylglycinexylidide4310.1F5, GPT
2ximelagatran43 1211.1F5, GPT
3acarbose43 1211.0INS, GPT
4desogestrel43 1211.0F5, INS
5hind iii439.8CD46, F5
6nash439.8INS, GPT
7metformin43 49 1211.8F5, INS, GPT
8policosanol439.7GPT, PIK3C2A
9penicillin439.7F5, IGHE
10ezetimibe43 1210.7INS, GPT
11alpha-hydroxybutyrate439.7GPT, PIK3C2A
12p-007439.7GPT, PIK3C2A
13acetaminophen43 2 49 24 1213.6IGHE, GPT, F5
14protamine439.6F5, INS, IGHE
15cyproteroneacetate439.6F5, INS
16tacrolimus43 49 1211.5GPT, INS, F5
17cyclophosphamide43 49 1211.5CD46, F5, IGHE
18hydrocortisone43 2 59 1212.5IGHE, INS, F5
19succinylcholine43 49 28 1212.4PIK3C2A, IGHE
20warfarin43 49 24 1212.3F5, GPT, PIK3C2A
21malondialdehyde439.3PIK3C2A, GPT, F5
22gemfibrozil28 43 1211.3PIK3C2A, GPT, INS
23bezafibrate43 28 1211.3INS, GPT, PIK3C2A
24fenofibrate43 49 1211.3INS, GPT, PIK3C2A
25vitamin-e439.3F5, GPT, PIK3C2A
26atorvastatin43 49 28 24 1213.3PIK3C2A, GPT, F5
27urea43 24 1211.3PIK3C2A, GPT, F5
28cocaine43 1210.3F5, GPT, PIK3C2A
29simvastatin43 49 59 28 24 1214.2PIK3C2A, GPT, F5
30ivig439.2PIK3C2A, IGHE, GPT
31prednisolone43 28 1211.1PIK3C2A, IGHE, GPT
32choline43 24 1211.1GPT, IGHE, PIK3C2A
33uric acid43 2410.0PIK3C2A, GPT, INS, F5
34glycerol43 24 1210.9INS, IGHE, PIK3C2A
35fibrinogen438.9PIK3C2A, GPT, INS, F5
36glycogen43 249.9F5, INS, GPT, PIK3C2A
37pge1438.9F5, GPT, IGHE, PIK3C2A
38cyclosporin a43 28 5910.8PIK3C2A, IGHE, GPT, CD46
39heroin43 49 1210.8IGHE, PIK3C2A
40thyroxine43 249.8PIK3C2A, IGHE, GPT, INS
41methotrexate49 43 1210.8PIK3C2A, IGHE, GPT
42epinephrine43 24 1210.8PIK3C2A, IGHE, INS, F5
43aspartate438.7F5, GPT, IGHE, PIK3C2A
44cholesterol43 28 24 1211.7PIK3C2A, GPT, INS, F5
45testosterone43 59 24 1211.6PIK3C2A, IGHE, INS, F5
46lactate438.4PIK3C2A, IGHE, GPT, INS, F5
47creatinine438.4F5, INS, GPT, IGHE, PIK3C2A
48arginine438.4PIK3C2A, IGHE, GPT, INS, F5
49glutamate438.4PIK3C2A, IGHE, GPT, INS, F5
50alanine438.1PIK3C2A, IGHE, GPT, INS, F5, CD46

GO Terms for genes affiliated with Necrotizing Fasciitis

About this section

Products for genes affiliated with Necrotizing Fasciitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Necrotizing Fasciitis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet