MCID: NCR007
MIFTS: 39

Necrotizing Fasciitis malady

Rare diseases category

Aliases & Classifications for Necrotizing Fasciitis

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Aliases & Descriptions for Necrotizing Fasciitis:

Name: Necrotizing Fasciitis 10 45 12 2 65
 
Fasciitis, Necrotizing 36


Classifications:



External Ids:

Disease Ontology10 DOID:9602
MeSH36 D019115
NCIt42 C84916
SNOMED-CT59 186428007, 52486002
ICD9CM29 728.86
ICD1027 M72.6

Summaries for Necrotizing Fasciitis

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NIH Rare Diseases:45 Necrotizing fasciitis is a serious bacterial infection of the skin, subcutaneous tissue (tissue just beneath the skin) and fascia. the infection can be sudden and fast-spreading. the bacteria involved enters the body through an external injury and attacks the surrounding tissues, eventually causing them to die. early signs include flu-like symptoms and redness or pain around the infection site, followed by very high fever, severe pain, swelling and blistering. if the infection is not treated promptly, it may cause multiple organ failure and death. treatment typically includes intravenous antibiotics; surgery to remove infected and dead tissue; hyperbaric oxygen therapy; and intravenous immune globulin therapy. last updated: 5/16/2012

MalaCards based summary: Necrotizing Fasciitis, also known as fasciitis, necrotizing, is related to pyelonephritis and melioidosis. An important gene associated with Necrotizing Fasciitis is CD46 (CD46 Molecule, Complement Regulatory Protein), and among its related pathways are TSLP Signaling Pathway and African trypanosomiasis. Affiliated tissues include skin, eye and breast, and related mouse phenotypes are immune system and cardiovascular system.

CDC:2 Group A Streptococcus (group A strep, GAS) bacteria can live in a person's nose and throat. The bacteria are spread through contact with droplets from an infected person's cough or sneeze. If you touch your mouth, nose, or eyes after touching something that has these droplets on it, you may become ill. If you drink from the same glass or eat from the same plate as the sick person, you could also become ill. It is also possible for group A strep bacteria to spread from contact with sores from a group A strep skin infection.

Wikipedia:68 Necrotizing fasciitis (/ˈnɛkrəˌtaɪzɪŋ ˌfæʃiˈaɪtɪs/ or /ˌfæs-/), also spelled necrotising... more...

Related Diseases for Necrotizing Fasciitis

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Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to necrotizing fasciitis

Symptoms for Necrotizing Fasciitis

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Drugs & Therapeutics for Necrotizing Fasciitis

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Drugs for Necrotizing Fasciitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunoglobulin GPhase 2167
2Rho(D) Immune GlobulinPhase 2198
3Immunoglobulins, IntravenousPhase 2203
4
Carbon monoxidePhase 199281
Synonyms:
 
CO
Carbon monoxide
5
Azithromycinapproved30983905-01-555185, 53477736, 447043
Synonyms:
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
1-Oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-,(2R-(2R*,3S*
121470-24-4
75199_FLUKA
83905-01-5
9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A
AC-16014
AC1L9KEG
Aritromicina
Azasite
Azenil
Azifast
Azigram
Azimakrol
Azithramycine
Azithromycin
Azithromycin & Tumor Necrosis Factor
Azithromycin (AIDS Initiative)
Azithromycin (anhydrous)
Azithromycin Dihydrate
Azithromycin Monohydrate
Azithromycin Sterile
Azithromycin dihydrate
Azithromycin plus Tumor Necrosis Factor
Azithromycine
Azithromycine [French]
Azithromycinum
Azithromycinum [Latin]
Azitrocin
Azitromax
Azitromicina
Azitromicina [Spanish]
Azitromin
Azythromycin
BIDD:GT0792
BRN 5387583
BSPBio_002285
Bio-0676
C38H72N2O12
CCRIS 1961
CHEBI:2955
CHEMBL529
CID447043
CP-62993
CP62,993
CPD000471864
DCH3
DRG-0104
 
DivK1c_000233
HMS1922G12
HMS2094M11
HMS500L15
HSDB 7205
Hemomycin
IDI1_000233
KBio1_000233
KBio2_000787
KBio2_003355
KBio2_005923
KBio3_001505
KBioGR_000731
KBioSS_000787
LS-1834
MLS001055353
MLS001066331
MLS001201763
MLS001304005
MLS001332499
MLS001332500
Misultina
MolPort-002-507-426
N,N-Dimethyl-4-amino-benzaldehyde
NCGC00090753-01
NCGC00090753-02
NINDS_000233
NSC643732
SAM002589961
SMR000471864
SPBio_001544
SPECTRUM1503679
Spectrum2_001582
Spectrum3_000653
Spectrum4_000186
Spectrum5_001867
Spectrum_000307
Sumamed
Tromix
UNII-JTE4MNN1MD
XZ-450
Z-Pak
ZIT
Zentavion
Zithromac
Zithromax
Zithromax IV
Zithromycin
Zitromax
Zitromax Avium 600
Zmas
Zmax
azithromycin
6
Daptomycinapproved, investigational82103060-53-316129629
Synonyms:
103060-53-3
AKOS005146218
C12013
C72H101N17O26
CHEBI:600103
CHEMBL508162
Cidecin
Cubicin
Cubicin (TN)
D01080
DAPTOMYCIN
Dapcin
Daptomicina
Daptomicina [Spanish]
Daptomycin
Daptomycin (JAN/USAN/INN)
Daptomycin [USAN:INN:BAN]
Daptomycine
 
Daptomycine [French]
Daptomycinum
Daptomycinum [Latin]
Deptomycin
LS-171846
LY 146032
LY-146032
LY146032
MK-3009
MolPort-003-846-138
N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-ox
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
UNII-NWQ5N31VKK
daptomycin
nchembio.184-comp5

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Negative Pressure Wound Therapy With the Engenex™-Pump and Bio-Dome™ Dressing, an EvaluationRecruitingNCT01107821Phase 4
2Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue InfectionsRecruitingNCT02469857Phase 3
3Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled TrialRecruitingNCT02111161Phase 2
4A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic ChildrenCompletedNCT00670891Phase 1
5Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing FasciitisCompletedNCT01739959
6Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological FeaturesCompletedNCT01139112
7Outcome and Related Factors of Necrotizing Fasciitis of the LimbCompletedNCT00538577
8Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue InfectionsCompletedNCT00261807
9Biomarkers in Patients With Flesh-eating Bacterial InfectionsCompletedNCT02180906
10Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital TractCompletedNCT00299663
11Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean InfectionCompletedNCT01235546
12Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs).RecruitingNCT01790698
13Genetic Susceptibility to Severe Streptococcal InfectionsRecruitingNCT01911572
14Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen TreatmentRecruitingNCT02501382
15Severe Soft Tissue Infections: Perspectives of Patients and Significant OthersRecruitingNCT02169128
16Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus InfectionsRecruitingNCT01731483
17Hyperglycemia in Surgical InfectionsTerminatedNCT00353275
18Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA)WithdrawnNCT00896402

Search NIH Clinical Center for Necrotizing Fasciitis


Cochrane evidence based reviews: Fasciitis, Necrotizing

Genetic Tests for Necrotizing Fasciitis

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Anatomical Context for Necrotizing Fasciitis

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MalaCards organs/tissues related to Necrotizing Fasciitis:

33
Skin, Eye, Breast, Bone, Liver, Colon, Kidney

Animal Models for Necrotizing Fasciitis or affiliated genes

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MGI Mouse Phenotypes related to Necrotizing Fasciitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053877.3CRP, CXCL8, IL18, IL1RN, IL2, IL6
2MP:00053856.7CRP, IL18, IL1RN, IL2, IL6, LTA

Publications for Necrotizing Fasciitis

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Articles related to Necrotizing Fasciitis:

(show top 50)    (show all 605)
idTitleAuthorsYear
1
Necrotizing fasciitis in patients with head and neck cancer. (25721060)
2015
2
A practitioner's guide to necrotizing fasciitis. (25774815)
2015
3
A fatal case of multidrug resistant acinetobacter necrotizing fasciitis: the changing scary face of nosocomial infection. (25349748)
2014
4
Fulminant necrotizing fasciitis caused by Serratia marcescens in an immunosuppressed host. (22640271)
2014
5
Temporizing surgical management improves outcome in patients with Vibrio necrotizing fasciitis complicated with septic shock on admission. (24138809)
2013
6
Facial necrotizing fasciitis. (23859680)
2013
7
Necrotizing fasciitis: contribution and limitations of diagnostic imaging. (23043899)
2013
8
Necrotizing fasciitis in patients who underwent renal transplantation. (23972528)
2013
9
Necrotizing fasciitis involving the chest and abdominal wall caused by Raoultella planticola. (22423899)
2012
10
Necrotizing fasciitis caused by a primary appendicocutaneous fistula. (22318638)
2012
11
Cervicofacial necrotizing fasciitis following periodontal abscess. (22782044)
2012
12
Group a streptococcus necrotizing fasciitis of the eyelid: a case report of good outcome with medical management. (21415799)
2012
13
Klebsiella pneumoniae cervical necrotizing fasciitis originating as an abscess. (22809880)
2012
14
Life-threatening necrotizing fasciitis due to 'bath salts' injection. (22229605)
2012
15
Factors associated with the mediastinal spread of cervical necrotizing fasciitis. (22115335)
2012
16
Atypical presentation of abdominal group A streptococcal-necrotizing fasciitis after pessary removal. (21789662)
2012
17
Necrotizing Fasciitis of the Cervical Region following Extravasation Injury. (23251188)
2012
18
Diagnosis and management of necrotizing fasciitis. (21410101)
2011
19
Unusual case of necrotizing fasciitis caused by Vibrio cholerae O137. (21159937)
2011
20
Transfer status: a risk factor for mortality in patients with necrotizing fasciitis. (21783216)
2011
21
Necrotizing fasciitis: an unusual presentation. (23024950)
2011
22
Necrotizing fasciitis: early sonographic diagnosis. (21480291)
2011
23
Necrotizing fasciitis of the head and neck. (20848400)
2010
24
Adapting a Vacuum Assisted Closure dressing to challenging wounds: negative pressure treatment for perineal necrotizing fasciitis with rectal prolapse in a newborn affected by acute myeloid leukaemia. (20406723)
2010
25
Molecular pathogenesis of necrotizing fasciitis. (19737105)
2010
26
Necrotizing fasciitis due to Pseudomonas aeruginosa in immuno-compromised children. (20486189)
2010
27
Long-term outcomes of patients with necrotizing fasciitis. (20061842)
2010
28
Necrotizing fasciitis due to acute perforated appendicitis: case report. (18226875)
2010
29
Extended retroperitoneal necrotizing fasciitis with genital involvement, resembling fournier gangrene. (20583955)
2010
30
Necrotizing fasciitis in southeast Taiwan: clinical features, microbiology, and prognosis. (18922719)
2009
31
The epidemiology of necrotizing fasciitis including factors associated with death and amputation. (19351432)
2009
32
Immune cell subsets in necrotizing fasciitis: an immunohistochemical analysis. (19529958)
2009
33
Necrotizing fasciitis in a patient treated with etanercept for dermatomyositis. (18795294)
2009
34
Necrotizing fasciitis and myonecrosis "synergistic necrotizing cellulitis" caused by Bacillus cereus. (19583692)
2009
35
Recurrent thigh abscess with necrotizing fasciitis from a retained transobturator sling segment. (19110187)
2009
36
Cervico-facial necrotizing fasciitis. (19207484)
2009
37
Necrotizing fasciitis. Case report. (19093634)
2008
38
Community-acquired methicillin-resistant Staphylococcus aureus emerging as an important cause of necrotizing fasciitis. (18399783)
2008
39
Severe necrotizing fasciitis complicating odontogenic nfection: a case report. (18605530)
2008
40
A case of necrotizing fasciitis due to Streptococcus agalactiae, Arcanobacterium haemolyticum, and Finegoldia magna in a dog-bitten patient with diabetes. (18594170)
2008
41
Case cluster of necrotizing fasciitis and cellulitis associated with vein sclerotherapy. (18258105)
2008
42
A fatal case of necrotizing fasciitis due to bacterial translocation of Klebsiella oxytoca. (18297453)
2008
43
Cervical necrotizing fasciitis in an uncontrolled type II diabetic patient. (18603881)
2006
44
A pilot study of cytokine levels and white blood cell counts in the diagnosis of necrotizing fasciitis. (16338511)
2006
45
Massive soft tissue infections: necrotizing fasciitis and purpura fulminans. (15715517)
2005
46
Streptococcal necrotizing fasciitis with toxic shock syndrome following cervical adenitis. (15302155)
2004
47
Conventional open surgery versus percutaneous catheter drainage in the treatment of cervical necrotizing fasciitis and descending necrotizing mediastinitis. (15149988)
2004
48
Post-varicella epiglottitis and necrotizing fasciitis. (10617750)
2000
49
Report of 2 fatal cases of adult necrotizing fasciitis and toxic shock syndrome caused by Streptococcus agalactiae. (11049806)
2000
50
Surgical implications of necrotizing fasciitis in children with chickenpox. (8863250)
1996

Variations for Necrotizing Fasciitis

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Expression for genes affiliated with Necrotizing Fasciitis

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Search GEO for disease gene expression data for Necrotizing Fasciitis.

Pathways for genes affiliated with Necrotizing Fasciitis

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Pathways related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8CXCL8, IL6
29.8IL18, IL6
39.7IL2, IL6
49.6IL18, IL2
59.5IL2, LTA
6
Salmonella infection (KEGG)
Show member pathways
9.4IL2, LTA
79.4CXCL8, IL18, IL6
89.4CXCL8, IL18, IL6
9
Show member pathways
9.4CXCL8, IL18, IL6
109.4CXCL8, IL18, IL6
119.4CXCL8, IL2, IL6
129.4CXCL8, IL2, IL6
139.4CXCL8, IL2, IL6
149.2CXCL8, IL1RN, IL6
15
Show member pathways
9.2CXCL8, IL2, LTA
16
Show member pathways
8.8CXCL8, IL18, IL1RN, IL6
17
Show member pathways
8.8IL18, IL2, IL6, LTA
18
Show member pathways
8.8IL18, IL2, IL6, LTA
19
Show member pathways
8.5CXCL8, IL18, IL2, IL6, LTA
20
Show member pathways
8.5CXCL8, IL18, IL2, IL6, LTA
21
Show member pathways
8.2CD46, CXCL8, IL18, IL2, IL6, LTA
22
Show member pathways
7.3CD46, CRP, IL18, IL1RN, IL2, IL6

GO Terms for genes affiliated with Necrotizing Fasciitis

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Cellular components related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.5CRP, CXCL8, IL18, IL1RN, IL2, IL6
2extracellular spaceGO:00056157.3CRP, CXCL8, IL18, IL1RN, IL2, IL6

Biological processes related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of tissue remodelingGO:003410510.3IL18, IL2
2positive regulation of interleukin-17 productionGO:003274010.3IL18, IL2
3positive regulation of immunoglobulin secretionGO:005102410.3IL2, IL6
4negative regulation of lipid storageGO:001088810.2CRP, IL6
5positive regulation of regulatory T cell differentiationGO:004559110.2CD46, IL2
6natural killer cell activationGO:003010110.2IL18, IL2
7positive regulation of activated T cell proliferationGO:004210410.2IL18, IL2
8positive regulation of tyrosine phosphorylation of Stat3 proteinGO:004251710.1IL18, IL6
9cellular response to lipopolysaccharideGO:00712229.7CXCL8, IL18, IL6
10positive regulation of interferon-gamma productionGO:00327299.7IL18, IL2, LTA
11acute-phase responseGO:00069539.5CRP, IL1RN, IL6
12response to lipopolysaccharideGO:00324969.3IL1RN, IL6, LTA
13defense response to Gram-positive bacteriumGO:00508309.2CRP, IL6, LTA
14inflammatory responseGO:00069549.1CRP, CXCL8, IL18, IL6
15positive regulation of T cell proliferationGO:00421029.1CD46, IL2, IL6
16positive regulation of gene expressionGO:00106288.9CD46, CRP, IL18, IL6
17immune responseGO:00069557.9CXCL8, IL18, IL1RN, IL2, IL6, LTA

Molecular functions related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.2IL18, IL1RN, IL2, IL6, LTA

Sources for Necrotizing Fasciitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet