Aliases & Classifications for Necrotizing Fasciitis

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Aliases & Descriptions for Necrotizing Fasciitis:

Name: Necrotizing Fasciitis 11 48 2 13 68
 
Fasciitis, Necrotizing 39

Classifications:



External Ids:

Disease Ontology11 DOID:9602
ICD1030 M72.6
ICD9CM32 728.86
SNOMED-CT62 186428007, 52486002
MeSH39 D019115
NCIt45 C84916

Summaries for Necrotizing Fasciitis

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NIH Rare Diseases:48 Necrotizing fasciitis is a serious infection of the skin, the tissue just beneath the skin (subcutaneous tissue), and the tissue that covers internal organs (fascia). necrotizing fasciitis can be caused by several different types of bacteria, and the infection can arise suddenly and spread quickly. early signs include flu-like symptoms and redness and pain around the infection site. a prompt diagnosis and treatment are essential. if the infection is not treated promptly, it can lead to multiple organ failure and death. treatment typically includes intravenous (iv) antibiotics and surgery to remove infected and dead tissue. last updated: 4/12/2016

MalaCards based summary: Necrotizing Fasciitis, also known as fasciitis, necrotizing, is related to rheumatoid arthritis and fournier gangrene, and has symptoms including spasm and generalized muscle weakness. An important gene associated with Necrotizing Fasciitis is CD46 (CD46 Molecule), and among its related pathways are Validated transcriptional targets of AP1 family members Fra1 and Fra2 and Overview of nanoparticle effects. Affiliated tissues include skin, eye and breast, and related mouse phenotype cardiovascular system.

CDC:2 Group A Streptococcus (group A strep) is a bacterium that can cause many different infections, including strep throat, scarlet fever, impetigo, and others. The bacteria live in the nose and throat. When someone who is infected coughs or sneezes, the bacteria travel in small droplets of water called respiratory droplets. One of the ways you can get sick is if you breathe in those droplets or if you touch something that has the droplets on it and then touch your mouth, nose, or eyes.

Wikipedia:71 Necrotising fasciitis (NF), commonly known as flesh-eating disease, is an infection that results in the... more...

Related Diseases for Necrotizing Fasciitis

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Diseases related to Necrotizing Fasciitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis29.4CXCL8, IL18, IL1RN, IL2, IL6, LTA
2fournier gangrene11.4
3fasciitis11.0
4cervicitis10.4
5oculomotor nerve paralysis10.3CXCL8, IL6
6common peroneal nerve lesion10.3CXCL8, IL6
7neonatal hypoxic and ischemic brain injury10.3CXCL8, IL6
8acute gonococcal cystitis10.2CXCL8, IL18
9psychotic disorder10.2CXCL8, IL6
10chromophobe adenoma10.2CXCL8, IL2
11egg allergy10.2IL18, IL1RN
12coronary arterial fistulas10.2CXCL8, IL1RN
13cutaneous sclerosis10.2IL1RN, IL6
14shoulder impingement syndrome10.2IL1RN, IL6
15toxic shock syndrome10.2
16pneumonia10.2
17schwannoma of ureter10.2CXCL8, IL6
18retinal vascular disease10.2CXCL8, IL6
19childhood electroclinical syndrome10.2CXCL8, IL6
20kaposiform hemangioendothelioma10.2IL2, LTA
21acute panmyelosis with myelofibrosis10.2CXCL8, IL6
22fallopian tube carcinoma10.2CXCL8, IL2
23drug dependence10.2IL6, LTA
24acquired thrombocytopenia10.2CXCL8, IL18, IL6
25allergic bronchopulmonary aspergillosis10.2CXCL8, IL18, IL6
26lacrimal system cancer10.2CXCL8, IL18, IL6
27plantar wart10.2CXCL8, IL2
28benign neonatal seizures10.2IL18, IL1RN, IL6
29laryngotracheoesophageal cleft type 210.1IL18, IL2, IL6
30kidney leiomyosarcoma10.1IL1RN, IL6
31autosomal recessive type iv ehlers-danlos syndrome10.1CXCL8, IL1RN, IL6
32classic type lipoma10.1CXCL8, IL1RN, IL6
33esophagus lymphoma10.1CXCL8, IL6
34labyrinthine bilateral reactive loss10.1CXCL8, IL2, IL6
35histiocytosis10.1CXCL8, IL1RN, IL6
36thyroid hyalinizing trabecular adenoma10.1CXCL8, IL2, IL6
37mediastinitis10.1
38intratubular embryonal carcinoma10.1CXCL8, IL1RN, IL6
39lichen disease10.1CXCL8, IL2, IL6
40gastroduodenitis10.1CD46, IL2, IL6
41pigmentation disease10.1CXCL8, IL2, IL6
42detrusor sphincter dyssynergia10.1CXCL8, IL2, IL6
43adnp syndrome10.1CXCL8, IL6, LTA
44wagr syndrome10.1CXCL8, IL2, IL6
45streptococcal toxic-shock syndrome10.1
46exophthalmos10.1CXCL8, IL2, IL6
47retinal vascular occlusion10.1CXCL8, IL1RN, LTA
48collagenous colitis10.1CXCL8, IL2, IL6
49necrotizing soft tissue infection10.1
50glycogen storage disease ix10.1CXCL8, IL18, IL6

Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to necrotizing fasciitis

Symptoms & Phenotypes for Necrotizing Fasciitis

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UMLS symptoms related to Necrotizing Fasciitis:


spasm, generalized muscle weakness

MGI Mouse Phenotypes related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.1CCNF, CD46, IL18, IL1RN, IL2, IL6

Drugs & Therapeutics for Necrotizing Fasciitis

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Drugs for Necrotizing Fasciitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunoglobulins, IntravenousPhase 2333
2Rho(D) Immune GlobulinPhase 2326
3ImmunoglobulinsPhase 26394
4Immunoglobulin GPhase 2275
5gamma-GlobulinsPhase 2326
6AntibodiesPhase 26394
7
Carbon monoxideapprovedPhase 1124630-08-0281
Synonyms:
CO
 
Carbon monoxide
Carboneum oxygenisatum
carbon(II) oxide
8
Azithromycinapproved34683905-01-555185, 53477736, 447043
Synonyms:
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
1-Oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-,(2R-(2R*,3S*
121470-24-4
75199_FLUKA
83905-01-5
9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A
AC-16014
AC1L9KEG
Aritromicina
Azasite
Azenil
Azifast
Azigram
Azimakrol
Azithramycine
Azithromycin
Azithromycin & Tumor Necrosis Factor
Azithromycin (AIDS Initiative)
Azithromycin (anhydrous)
Azithromycin Dihydrate
Azithromycin Monohydrate
Azithromycin Sterile
Azithromycin dihydrate
Azithromycin plus Tumor Necrosis Factor
Azithromycine
Azithromycine [French]
Azithromycinum
Azithromycinum [Latin]
Azitrocin
Azitromax
Azitromicina
Azitromicina [Spanish]
Azitromin
Azythromycin
BIDD:GT0792
BRN 5387583
BSPBio_002285
Bio-0676
C38H72N2O12
CCRIS 1961
CHEBI:2955
CHEMBL529
CID447043
CP-62993
CP62,993
CPD000471864
DCH3
DRG-0104
 
DivK1c_000233
HMS1922G12
HMS2094M11
HMS500L15
HSDB 7205
Hemomycin
IDI1_000233
KBio1_000233
KBio2_000787
KBio2_003355
KBio2_005923
KBio3_001505
KBioGR_000731
KBioSS_000787
LS-1834
MLS001055353
MLS001066331
MLS001201763
MLS001304005
MLS001332499
MLS001332500
Misultina
MolPort-002-507-426
N,N-Dimethyl-4-amino-benzaldehyde
NCGC00090753-01
NCGC00090753-02
NINDS_000233
NSC643732
SAM002589961
SMR000471864
SPBio_001544
SPECTRUM1503679
Spectrum2_001582
Spectrum3_000653
Spectrum4_000186
Spectrum5_001867
Spectrum_000307
Sumamed
Tromix
UNII-JTE4MNN1MD
XZ-450
Z-Pak
ZIT
Zentavion
Zithromac
Zithromax
Zithromax IV
Zithromycin
Zitromax
Zitromax Avium 600
Zmas
Zmax
azithromycin
9
Daptomycinapproved, investigational88103060-53-316129629
Synonyms:
103060-53-3
AKOS005146218
C12013
C72H101N17O26
CHEBI:600103
CHEMBL508162
Cidecin
Cubicin
Cubicin (TN)
D01080
DAPTOMYCIN
Dapcin
Daptomicina
Daptomicina [Spanish]
Daptomycin (JAN/USAN/INN)
Daptomycin [USAN:INN:BAN]
Daptomycine
 
Daptomycine [French]
Daptomycinum
Daptomycinum [Latin]
Deptomycin
LS-171846
LY 146032
LY-146032
LY146032
MK-3009
MolPort-003-846-138
N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-ox
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
UNII-NWQ5N31VKK
daptomycin
nchembio.184-comp5
10Anti-Infective Agents22062
11Antibiotics, Antitubercular7180
12Anti-Bacterial Agents11226
13Protein C118

Interventional clinical trials:

(show all 20)
idNameStatusNCT IDPhase
1Negative Pressure Wound Therapy With the Engenex™-Pump and Bio-Dome™ Dressing, an EvaluationUnknown statusNCT01107821Phase 4
2Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue InfectionsRecruitingNCT02469857Phase 3
3Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled TrialCompletedNCT02111161Phase 2
4A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic ChildrenCompletedNCT00670891Phase 1
5Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus InfectionsUnknown statusNCT01731483
6Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing FasciitisCompletedNCT01739959
7Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological FeaturesCompletedNCT01139112
8Outcome and Related Factors of Necrotizing Fasciitis of the LimbCompletedNCT00538577
9Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue InfectionsCompletedNCT00261807
10Biomarkers in Patients With Flesh-eating Bacterial InfectionsCompletedNCT02180906
11Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital TractCompletedNCT00299663
12Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean InfectionCompletedNCT01235546
13Factors Associated With Complications of Cervical Necrotizing FasciitisRecruitingNCT02847234
14Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs).RecruitingNCT01790698
15Severe Soft Tissue Infections: Perspectives of Patients and Significant OthersRecruitingNCT02169128
16Genetic Susceptibility to Severe Streptococcal InfectionsRecruitingNCT01911572
17Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen TreatmentRecruitingNCT02501382
18Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort StudyRecruitingNCT03147352
19Hyperglycemia in Surgical InfectionsTerminatedNCT00353275
20Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA)WithdrawnNCT00896402

Search NIH Clinical Center for Necrotizing Fasciitis


Cochrane evidence based reviews: fasciitis, necrotizing

Genetic Tests for Necrotizing Fasciitis

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Anatomical Context for Necrotizing Fasciitis

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MalaCards organs/tissues related to Necrotizing Fasciitis:

36
Skin, Eye, Breast, Colon, Liver, Kidney, Tonsil

Publications for Necrotizing Fasciitis

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Articles related to Necrotizing Fasciitis:

(show top 50)    (show all 675)
idTitleAuthorsYear
1
Application of a Silicone Sheet in Negative-Pressure Wound Therapy to Treat an Abdominal Wall Defect after Necrotizing Fasciitis. (28194352)
2017
2
Concurrent external and intraluminal vacuum-assisted closure in head and neck necrotizing fasciitis. (28084021)
2017
3
Necrotizing Fasciitis in Aesthetic Surgery: A Review of the Literature. (28062962)
2017
4
First case report of Nocardia brasiliensis infection causing necrotizing fasciitis in an immunocompetent patient. (27117138)
2016
5
Pyoderma gangrenosum and necrotizing fasciitis-like opportunistic invasive cutaneous fungal infection. (27126743)
2016
6
Bilateral Necrotizing Fasciitis of the Foot Associated with Group B Streptococcus. (27790114)
2016
7
Skin-Sparing DAcbridement for Necrotizing Fasciitis in Children. (27556624)
2016
8
A 10-Year Review of Necrotizing Fasciitis in the Pediatric Population: Delays to Diagnosis and Management. (27663964)
2016
9
Evaluation of Factors Associated with Death in Patients with Necrotizing Fasciitis of the Abdominal Wall. (27929925)
2016
10
It's Not Always What It Seems: Necrotizing Fasciitis Mimicking Angioedema. (27072731)
2016
11
The Free-style Gluteal Perforator Flap in the Thinning and Delay Process for Perineal Reconstruction After Necrotizing Fasciitis. (27434419)
2016
12
Diagnosis and Treatment of Pediatric Necrotizing Fasciitis: A Systematic Review of the Literature. (27380058)
2016
13
Sequential necrotizing fasciitis caused by the monomicrobial pathogens Streptococcus equisimilis and extended-spectrum beta-lactamase-producing Escherichia coli. (26912298)
2016
14
Ludwig's angina complicated by fatal cervicofascial and mediastinal necrotizing fasciitis. (27077024)
2016
15
First report of monomicrobial Candida parapsilosis necrotizing fasciitis. (27385469)
2016
16
Salvage therapy with intravenous fosfomycin plus ceftriaxone for necrotizing fasciitis caused by penicillin-nonsusceptible Streptococcus pneumoniae. (28082065)
2016
17
What's new in emergencies, trauma and shock? The tortuous path in the management of necrotizing fasciitis: Is early surgical intervention critical? (26957818)
2016
18
Cervical Necrotizing Fasciitis Caused by Dental Extraction. (27375905)
2016
19
Triple diagnostics for early detection of ambivalent necrotizing fasciitis. (27766113)
2016
20
Rare Complication of Stomas: Peristomal Necrotizing Fasciitis. (28054929)
2016
21
A case report of necrotizing fasciitis of the abdominal wall: A rare, life-threatening complication of a common disease process. (27794239)
2016
22
Successful Treatment of a Case of Necrotizing Fasciitis due to Vibrio vulnificus in a Cold Climate in Japan. (27086822)
2016
23
Case Report of Necrotizing Fasciitis Associated with Streptococcus pneumoniae. (27366176)
2016
24
Isolated digital necrotizing fasciitis: an unusual presentation. (27881796)
2016
25
Necrotic fasciitis of the lateral muscle group of the thigh following outside-in transobturatory tape procedure. (27918157)
2016
26
Necrotizing fasciitis of anterior abdominal wall following cesarean section in a low-risk patient. (27402541)
2016
27
Necrotizing fasciitis associated with systemic lupus erythematosus in a child. (27626093)
2016
28
Necrotizing Fasciitis of the Lower Extremity Caused by Serratia marcescens A Case Report. (27031553)
2016
29
AA rare case of necrotizing fasciitis caused by Vibrio cholerae O8 in an immunocompetent patient. (27604649)
2016
30
Necrotizing fasciitis in a patient receiving tocilizumab for rheumatoid arthritis - Case report. (28041910)
2016
31
Necrotizing fasciitis due to Streptococcus mitis caused by accidental human bite. (26829544)
2016
32
A Necrotizing Fasciitis Fake Out on Point-of-Care Ultrasound-Watch the Shadow. (27743718)
2016
33
Pattern and predictors of mortality in necrotizing fasciitis patients in a single tertiary hospital. (27508002)
2016
34
Ascending Facial Necrotizing Fasciitis in a Patient Taking a Bisphosphonate. (27639154)
2016
35
Two non-otic cases of POM-1 metallo-I^-lactamase-producing Pseudomonas otitidis infection: Necrotizing fasciitis and pan-peritonitis. (27835844)
2016
36
Impact of Intravenous Immunoglobulin on Survival in Necrotizing Fasciitis with Vasopressor-dependent Shock: A Propensity-Score Matched Analysis from 130 US Hospitals. (28034881)
2016
37
The diagnosis you wish you had never operated on: Pyoderma gangrenosum misdiagnosed as necrotizing fasciitis-a case report. (27875063)
2016
38
Nonodontogenic Cervical Necrotizing Fasciitis Caused by Sialadenitis. (27822398)
2016
39
Odontogenic cervical necrotizing fasciitis, etiological aspects. (27022806)
2016
40
Assessment of Administrative Medical Claims Data for Public Health Surveillance of Invasive Group A Streptococcal Necrotizing Fasciitis in Tennessee. (27453600)
2016
41
Sonographic Findings in Necrotizing Fasciitis: Two Ends of the Spectrum. (27582527)
2016
42
Primary Necrotizing Fasciitis of the Breast in an Untreated Patient with Diabetes. (27896201)
2016
43
Necrotizing Fasciitis Presenting as an Itchy Thigh. (27579187)
2016
44
Necrotizing fasciitis due to Vibrio cholerae non-O1/non-O139 after exposure to Austrian bathing sites. (26825075)
2016
45
Fatal Fulminant Retroperitoneal Necrotizing Fasciitis Caused by Streptococcus viridans. (27097613)
2016
46
Flow-through Instillation of Hypochlorous Acid in the Treatment of Necrotizing Fasciitis. (26891136)
2016
47
Comment on: "Cervical Necrotizing Fasciitis-The Value of the Laboratory Risk Indicator for Necrotizing Fasciitis Score as an Indicative Parameter". (26963076)
2016
48
Necrotizing Fasciitis as a Complication of a Continuous Sciatic Nerve Catheter Using the Lateral Popliteal Approach. (27662064)
2016
49
Necrotizing fasciitis associated with systemic lupus erythematosus in a child. (27559515)
2016
50
Synchronous multifocal necrotizing fasciitis prognostic factors: a retrospective case series study in a single center. (27778190)
2016

Variations for Necrotizing Fasciitis

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Expression for genes affiliated with Necrotizing Fasciitis

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Search GEO for disease gene expression data for Necrotizing Fasciitis.

Pathways for genes affiliated with Necrotizing Fasciitis

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Pathways related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathwaysScoreTop Affiliating Genes
19.9CXCL8, IL6
29.9CXCL8, IL6
39.8IL18, IL6
49.8IL18, IL6
59.7IL2, IL6
69.7IL18, IL2
79.6IL2, LTA
8
Show member pathways
9.5CXCL8, IL18, IL6
99.5CXCL8, IL18, IL6
109.5CXCL8, IL18, IL6
119.5CXCL8, IL18, IL6
129.5CXCL8, IL18, IL6
139.5CXCL8, IL1RN, IL6
14
Show member pathways
9.4CXCL8, IL2, IL6
159.4CXCL8, IL2, IL6
169.4CXCL8, IL2, IL6
179.4CXCL8, IL18, IL2
18
Show member pathways
9.3CXCL8, IL2, LTA
199.3IL18, IL2, LTA
209.1CXCL8, IL18, IL1RN, IL6
21
Show member pathways
9.0CXCL8, IL2, IL6, LTA
22
Show member pathways
8.9IL18, IL2, IL6, LTA
238.6CXCL8, IL18, IL2, IL6, LTA
24
Show member pathways
8.6CXCL8, IL18, IL2, IL6, LTA
25
Show member pathways
8.6CXCL8, IL18, IL2, IL6, LTA
26
Show member pathways
8.4CD46, CXCL8, IL18, IL2, IL6, LTA
27
Show member pathways
8.3CXCL8, IL18, IL1RN, IL2, IL6, LTA
28
Show member pathways
7.4CCNF, CD46, CXCL8, IL18, IL1RN, IL2

GO Terms for genes affiliated with Necrotizing Fasciitis

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Cellular components related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.3CXCL8, IL18, IL1RN, IL2, IL6, LTA

Biological processes related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of interleukin-1-mediated signaling pathwayGO:200066010.4IL1RN, IL6
2positive regulation of regulatory T cell differentiationGO:004559110.3CD46, IL2
3positive regulation of immunoglobulin secretionGO:005102410.3IL2, IL6
4natural killer cell activationGO:003010110.3IL18, IL2
5positive regulation of activated T cell proliferationGO:004210410.3IL18, IL2
6positive regulation of T-helper 2 cell differentiationGO:004563010.3IL18, IL6
7positive regulation of interleukin-17 productionGO:003274010.3IL18, IL2
8positive regulation of tissue remodelingGO:003410510.2IL18, IL2
9positive regulation of T cell proliferationGO:00421029.9CD46, IL2, IL6
10positive regulation of interferon-gamma productionGO:00327299.8IL18, IL2, LTA
11inflammatory responseGO:00069549.7CXCL8, IL18, IL1RN, IL6
12positive regulation of tyrosine phosphorylation of STAT proteinGO:00425319.4IL18, IL2, IL6
13immune responseGO:00069558.9CXCL8, IL18, IL1RN, IL2, IL6, LTA

Molecular functions related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00051258.3CXCL8, IL18, IL1RN, IL2, IL6, LTA

Sources for Necrotizing Fasciitis

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