Aliases & Classifications for Necrotizing Fasciitis

MalaCards integrated aliases for Necrotizing Fasciitis:

Name: Necrotizing Fasciitis 12 72 49 3 14 69
Fasciitis, Necrotizing 41

Classifications:



External Ids:

Disease Ontology 12 DOID:9602
ICD10 32 M72.6
ICD9CM 34 728.86
MeSH 41 D019115
NCIt 46 C84916
SNOMED-CT 64 186428007 52486002
UMLS 69 C0238124

Summaries for Necrotizing Fasciitis

NIH Rare Diseases : 49 Necrotizing fasciitis is a serious infection of the skin, the tissue just beneath the skin (subcutaneous tissue), and the tissue that covers internal organs (fascia). Necrotizing fasciitis can be caused by several different types of bacteria, and the infection can arise suddenly and spread quickly. Early signs include flu-like symptoms and redness and pain around the infection site. A prompt diagnosis and treatment are essential. If the infection is not treated promptly, it can lead to multiple organ failure and death. Treatment typically includes intravenous (IV) antibiotics and surgery to remove infected and dead tissue. Last updated: 4/12/2016

MalaCards based summary : Necrotizing Fasciitis, also known as fasciitis, necrotizing, is related to fasciitis and noma, and has symptoms including generalized muscle weakness and spasm. An important gene associated with Necrotizing Fasciitis is CD46 (CD46 Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Rho(D) Immune Globulin and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and breast, and related phenotype is cardiovascular system.

CDC : 3 Group A Streptococcus (group A strep) is a bacterium that can cause many different infections, including strep throat, scarlet fever, impetigo, and others. The bacteria live in the nose and throat. When someone who is infected coughs or sneezes, the bacteria travel in small droplets of water called respiratory droplets. One of the ways you can get sick is if you breathe in those droplets or if you touch something that has the droplets on it and then touch your mouth, nose, or eyes.

Wikipedia : 72 Necrotizing fasciitis (NF), commonly known as flesh-eating disease, is an infection that results in the... more...

Related Diseases for Necrotizing Fasciitis

Diseases related to Necrotizing Fasciitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 251)
# Related Disease Score Top Affiliating Genes
1 fasciitis 31.2 CD46 CXCL8 IL18 IL6 RPS17
2 noma 30.6 CXCL8 IL18
3 immune suppression 30.0 IL2 IL6
4 adult-onset still's disease 29.8 IL18 IL1RN IL6
5 perinatal necrotizing enterocolitis 29.8 CXCL8 IL6
6 conjunctivitis 29.7 CXCL8 IL2 IL6
7 colitis 29.7 CXCL8 IL2 IL6
8 arthritis 29.6 CXCL8 IL18 IL1RN IL6 LTA
9 tonsillitis 29.5 CXCL8 IL2 IL6 LTA
10 pharyngitis 29.4 CXCL8 MYOM2
11 toxic shock syndrome 29.4 CXCL8 IL2 IL6 LTA MYOM2
12 rheumatoid arthritis 29.4 CXCL8 IL18 IL1RN IL2 IL6
13 aplastic anemia 29.2 IL2 IL6 RPS17
14 streptococcal toxic-shock syndrome 29.2 CXCL8 IL2 IL6 LTA MYOM2
15 psoriasis 29.0 CXCL8 IL18 IL2 IL6 LTA
16 fournier gangrene 11.5
17 cervicitis 10.6
18 sapho syndrome 10.5 CXCL8 IL18
19 recurrent corneal erosion 10.5 CXCL8 IL6
20 bagassosis 10.5 CXCL8 IL6
21 acute transverse myelitis 10.4 CXCL8 IL6
22 denture stomatitis 10.4 CXCL8 IL6
23 papillary conjunctivitis 10.4 CXCL8 IL6
24 funisitis 10.4 CXCL8 IL6
25 stachybotrys chartarum 10.4 IL18 IL6
26 listeria meningitis 10.4 IL18 LTA
27 acute monoblastic leukemia 10.4 CXCL8 IL6
28 schnitzler syndrome 10.4 IL18 IL1RN
29 null-cell leukemia 10.4 IL6 LTA
30 meconium aspiration syndrome 10.4 CXCL8 IL6
31 cysticercosis 10.4 IL18 IL6
32 vaginal disease 10.4 CXCL8 IL6
33 pouchitis 10.4 CXCL8 IL1RN
34 louse-borne relapsing fever 10.4 CXCL8 IL6
35 vaginitis 10.4 CXCL8 IL6
36 preterm premature rupture of the membranes 10.4 CXCL8 IL6
37 cryopyrin-associated periodic syndrome 10.4 IL1RN IL6
38 endometrial disease 10.4 CXCL8 IL6
39 acute cholangitis 10.4 IL1RN IL6
40 transverse myelitis 10.4 CXCL8 IL6
41 toxicodendron dermatitis 10.4 CXCL8 IL2
42 pleural tuberculosis 10.4 CXCL8 IL18
43 cowpox 10.4 CXCL8 IL6
44 trichomoniasis 10.4 CXCL8 IL2
45 extramedullary plasmacytoma 10.3 IL2 IL6
46 juvenile spondyloarthropathy 10.3 IL2 LTA
47 clonorchiasis 10.3 CXCL8 IL2
48 retinitis pigmentosa 44 10.3 CXCL8 IL2
49 crohn's colitis 10.3 CXCL8 IL2
50 pneumonia 10.3

Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to Necrotizing Fasciitis

Symptoms & Phenotypes for Necrotizing Fasciitis

UMLS symptoms related to Necrotizing Fasciitis:


generalized muscle weakness, spasm

MGI Mouse Phenotypes related to Necrotizing Fasciitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 CCNF CD46 IL18 IL1RN IL2 IL6

Drugs & Therapeutics for Necrotizing Fasciitis

Drugs for Necrotizing Fasciitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Rho(D) Immune Globulin Phase 2
2 gamma-Globulins Phase 2
3 Immunoglobulins Phase 2
4 Immunoglobulins, Intravenous Phase 2
5 Antibodies Phase 2
6
Carbon monoxide Approved, Investigational Phase 1 630-08-0 281
7 Vaccines Phase 1
8 Pharmaceutical Solutions Phase 1
9
Daptomycin Approved, Investigational 103060-53-3 16129629
10
Protein C Approved
11 Anti-Bacterial Agents
12 Anti-Infective Agents

Interventional clinical trials:

(show all 21)

# Name Status NCT ID Phase Drugs
1 Negative Pressure Wound Therapy With the Engenex™-Pump and Bio-Dome™ Dressing, an Evaluation Unknown status NCT01107821 Phase 4
2 Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections Recruiting NCT02469857 Phase 3 AB103 0.5 mg/kg
3 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
4 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
5 Controlled Human Infection for Vaccination Against Streptococcus Pyogenes Not yet recruiting NCT03361163 Phase 1
6 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
7 Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections Unknown status NCT01731483
8 Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features Completed NCT01139112
9 Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing Fasciitis Completed NCT01739959
10 Outcome and Related Factors of Necrotizing Fasciitis of the Limb Completed NCT00538577
11 Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections Completed NCT00261807 Daptomycin 6mg/kg/day
12 Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Completed NCT03443544
13 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
14 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
15 Factors Associated With Complications of Cervical Necrotizing Fasciitis Recruiting NCT02847234
16 Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs). Recruiting NCT01790698
17 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
18 Genetic Susceptibility to Severe Streptococcal Infections Recruiting NCT01911572
19 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352
20 Hyperglycemia in Surgical Infections Terminated NCT00353275 Strict Glycemic control;Conventional Glycemic Control
21 Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA) Withdrawn NCT00896402 Skin antisepsis with chlorhexidine;povidone-iodine

Search NIH Clinical Center for Necrotizing Fasciitis

Cochrane evidence based reviews: fasciitis, necrotizing

Genetic Tests for Necrotizing Fasciitis

Anatomical Context for Necrotizing Fasciitis

MalaCards organs/tissues related to Necrotizing Fasciitis:

38
Skin, Eye, Breast, Colon, Liver, Kidney, Tonsil

Publications for Necrotizing Fasciitis

Articles related to Necrotizing Fasciitis:

(show top 50) (show all 719)
# Title Authors Year
1
Acute appendicitis complicated with necrotizing fasciitis in a patient with adult-onset Still's disease: A case report. ( 29384877 )
2018
2
Immunoglobulin Attenuates Streptokinase-Mediated Virulence in Streptococcus dysgalactiae Subspecies equisimilis Necrotizing Fasciitis. ( 29099935 )
2018
3
Necrotizing fasciitis following spinal anesthesia: A rare and devastating complication. ( 29416475 )
2018
4
Group B Streptococcal Cellulitis and Necrotizing Fasciitis in Infants: A Systematic Review. ( 29424798 )
2018
5
Necrotizing fasciitis following minor skin surgery in a patient receiving treatment with infliximab and prednisolone. ( 29400281 )
2018
6
The Incidence of Necrotizing Fasciitis in Taiwan: A Nationwide Population-Based Study. ( 29369913 )
2018
7
Re: Laboratory Risk Indicator for Necrotizing Fasciitis score for early diagnosis of necrotizing fasciitis in Darwin. ( 29205823 )
2017
8
Chest Necrotizing Fasciitis with Mediastinitis. ( 28674375 )
2017
9
Cervical-thoracic necrotizing fasciitis of odontogenic origin in a diabetic patient: a case report. ( 28682278 )
2017
10
Successful Treatment of Necrotizing Fasciitis and Streptococcal Toxic Shock Syndrome with the Addition of Linezolid. ( 28299216 )
2017
11
Post-partum streptococcal toxic shock syndrome associated with necrotizing fasciitis. ( 28725564 )
2017
12
Application of a Silicone Sheet in Negative-Pressure Wound Therapy to Treat an Abdominal Wall Defect after Necrotizing Fasciitis. ( 28194352 )
2017
13
Shewanella putrefaciens necrotizing fasciitis of the lower limb. ( 28734629 )
2017
14
Necrotizing Fasciitis: A Rare Complication of Acute Necrotizing Pancreatitis. ( 28764243 )
2017
15
Pasteurella multocida ecthyma complicated by necrotizing fasciitis. ( 28541874 )
2017
16
Fournier's Gangrene: Lessons Learned from Multimodal and Multidisciplinary Management of Perineal Necrotizing Fasciitis. ( 28740847 )
2017
17
A case of disseminated cryptococcosis with necrotizing fasciitis in a non-HIV patient. ( 29123908 )
2017
18
Cervical Necrotizing Fasciitis of Odontogenic Origin and Hyperbaric Oxygen Therapy. ( 28857997 )
2017
19
First Necrotizing Fasciitis Caused by<i>Haemophilus influenza</i>Serotype a. ( 29124073 )
2017
20
Candida parapsilosis associated with cervical necrotizing fasciitis and descending mediastinitis. ( 28458871 )
2017
21
Necrotizing fasciitis following venomous snakebites in a tertiary hospital of southwest Taiwan. ( 28811229 )
2017
22
Presenting features of extremity necrotizing fasciitis in the pediatric patient: a case-control analysis. ( 28877051 )
2017
23
Necrotizing Sweet's syndrome presenting as necrotizing fasciitis with a good response to immune suppressant treatment. ( 28815908 )
2017
24
Antimicrobial treatment of necrotizing fasciitis and septic polyarthritis in a cat associated with Streptococcus canis infection. ( 28776781 )
2017
25
Rapid identification of pathogens responsible for necrotizing fasciitis on an integrated microfluidic system. ( 29282420 )
2017
26
Response to Re: Laboratory Risk Indicator for Necrotizing Fasciitis score for early diagnosis of necrotizing fasciitis in Darwin. ( 29205831 )
2017
27
Cervical necrotizing fasciitis: an overlooked diagnosis of a fatal disease. ( 29105542 )
2017
28
Concurrent external and intraluminal vacuum-assisted closure in head and neck necrotizing fasciitis. ( 28084021 )
2017
29
Fusobacterium emphysematous pyomyositis with necrotizing fasciitis of the leg presenting as compartment syndrome: a case report. ( 29179775 )
2017
30
Necrotizing fasciitis of the lower leg caused by Escherichia coli, and an association with pyogenic spondylitis. ( 28925014 )
2017
31
A Randomized Controlled Trial on the Outcome in Comparing an Alginate Silver Dressing With a Conventional Treatment of a Necrotizing Fasciitis Wound. ( 28682725 )
2017
32
Necrotizing fasciitis associated with primary cutaneous B-cell lymphoma. A case report. ( 29205142 )
2017
33
Alcohol use disorder increases the risk of necrotizing fasciitis: A nationwide retrospective cohort study. ( 28796035 )
2017
34
Group A Streptococci-Associated Necrotizing Fasciitis following Cat Bite in an Immunocompromised Patient. ( 29348946 )
2017
35
Necrotizing fasciitis. Possible profiles of professional liability with reference to two cases. ( 29311423 )
2017
36
Necrotizing fasciitis after high-dose rate brachytherapy and external beam radiation for prostate cancer: a case report. ( 29162067 )
2017
37
Necrotizing fasciitis caused by genogroup A9 Neisseria meningitidis. ( 28911029 )
2017
38
Thigh Necrotizing Fasciitis Secondary to Perforated Sigmoid Diverticulitis. ( 29229358 )
2017
39
Hyperbaric oxygen may only be optional in head and neck necrotizing fasciitis: a retrospective analysis of 43 cases and review of the literature. ( 28644692 )
2017
40
Retroperitoneal Necrotizing Fasciitis from Fournier's Gangrene in an Immunocompromised Patient. ( 29333313 )
2017
41
Necrotizing Fasciitis in Aesthetic Surgery: A Review of the Literature. ( 28062962 )
2017
42
Clostridium perfringens necrotizing fasciitis with massive hemolysis. ( 28782816 )
2017
43
Whole-Genome Sequencing of a Human Clinical Isolate of<i>emm28 Streptococcus pyogenes</i>Causing Necrotizing Fasciitis Acquired Contemporaneously with Hurricane Harvey. ( 29122881 )
2017
44
Mesh erosion to urinary bladder causing fistulation to abdominal wall resulting in necrotizing fasciitis: A case report of late complication of incisional hernia. ( 28846952 )
2017
45
Negative Pressure Wound Therapy for a Giant Wound Secondary to Malignancy-induced Necrotizing Fasciitis: Case Report and Review of the Literature. ( 28862979 )
2017
46
It's Not Always What It Seems: Necrotizing Fasciitis Mimicking Angioedema. ( 27072731 )
2016
47
Pediatric Necrotizing Fasciitis: Restitutio Ad Integrum after Early Diagnosis and Aggressive Surgical Treatment. ( 28035291 )
2016
48
AA rare case of necrotizing fasciitis caused by Vibrio cholerae O8 in an immunocompetent patient. ( 27604649 )
2016
49
Necrotizing Fasciitis of the Lower Extremity Caused by Serratia marcescens A Case Report. ( 27031553 )
2016
50
Necrotizing fasciitis of anterior abdominal wall following cesarean section in a low-risk patient. ( 27402541 )
2016

Variations for Necrotizing Fasciitis

Expression for Necrotizing Fasciitis

Search GEO for disease gene expression data for Necrotizing Fasciitis.

Pathways for Necrotizing Fasciitis

Pathways related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 CCNF CD46 CXCL8 IL18 IL1RN IL2
2
Show member pathways
13.14 CXCL8 IL18 IL1RN IL2 IL6 LTA
3
Show member pathways
13.1 CXCL8 IL18 IL2 IL6 LTA
4
Show member pathways
12.65 CXCL8 IL2 IL6 LTA
5
Show member pathways
12.43 CD46 CXCL8 IL18 IL2 IL6 LTA
6 11.98 CXCL8 IL1RN IL6
7 11.83 CXCL8 IL2 IL6
8 11.8 CXCL8 IL18 IL6
9 11.7 CXCL8 IL18 IL2
10 11.67 CXCL8 IL18 IL6
11
Show member pathways
11.64 IL18 IL2 IL6 LTA
12 11.63 CXCL8 IL18 IL6
13
Show member pathways
11.61 CXCL8 IL2 LTA
14 11.58 CXCL8 IL2 IL6
15 11.56 IL18 IL2 LTA
16
Show member pathways
11.43 CXCL8 IL2 IL6
17 11.32 CXCL8 IL18 IL6
18 11.23 CXCL8 IL18 IL6
19
Show member pathways
11.23 CXCL8 IL18 IL2 IL6 LTA
20 11.19 IL18 IL6
21 11.17 CXCL8 IL6
22 11.13 IL18 IL6
23 11.1 IL2 IL6
24 11.06 IL18 IL2
25 11.03 IL2 LTA
26 10.95 CXCL8 IL18 IL1RN IL6
27 10.86 CXCL8 IL6
28 10.78 CXCL8 IL18 IL2 IL6 LTA
29 10.73 CXCL8 IL18 IL2 IL6 LTA

GO Terms for Necrotizing Fasciitis

Cellular components related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Biological processes related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.81 CXCL8 IL18 IL1RN IL6
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IL18 IL2 IL6
3 positive regulation of activated T cell proliferation GO:0042104 9.54 IL18 IL2
4 natural killer cell activation GO:0030101 9.52 IL18 IL2
5 positive regulation of T cell proliferation GO:0042102 9.5 CD46 IL2 IL6
6 positive regulation of interleukin-17 production GO:0032740 9.49 IL18 IL2
7 positive regulation of immunoglobulin secretion GO:0051024 9.48 IL2 IL6
8 neutrophil activation GO:0042119 9.46 CXCL8 IL18
9 positive regulation of regulatory T cell differentiation GO:0045591 9.43 CD46 IL2
10 immune response GO:0006955 9.43 CXCL8 IL18 IL1RN IL2 IL6 LTA
11 positive regulation of tissue remodeling GO:0034105 9.37 IL18 IL2
12 positive regulation of interferon-gamma production GO:0032729 9.33 IL18 IL2 LTA
13 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.26 IL1RN IL6
14 regulation of receptor activity GO:0010469 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Molecular functions related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Sources for Necrotizing Fasciitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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