MCID: NCR007
MIFTS: 41

Necrotizing Fasciitis malady

Summaries for Necrotizing Fasciitis

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Necrotizing fasciitis is a serious bacterial infection of the skin, subcutaneous tissue (tissue just beneath the skin) and fascia. the infection can be sudden and fast-spreading. the bacteria involved enters the body through an external injury and attacks the surrounding tissues, eventually causing them to die. early signs include flu-like symptoms and redness or pain around the infection site, followed by very high fever, severe pain, swelling and blistering. if the infection is not treated promptly, it may cause multiple organ failure and death. treatment typically includes intravenous antibiotics; surgery to remove infected and dead tissue; hyperbaric oxygen therapy; and intravenous immune globulin therapy. last updated: 5/16/2012

MalaCards: Necrotizing Fasciitis is related to toxic shock syndrome and pneumonia. An important gene associated with Necrotizing Fasciitis is CD46 (CD46 molecule, complement regulatory protein). The compounds warfarin and monoethylglycinexylidide have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and colon.

Wikipedia:63 Necrotizing fasciitis (/ˈnɛkrəˌtaɪzɪŋ ˌfæʃiˈaɪtɪs/ or /ˌfæs-/) or NF, commonly known as... more...

Aliases & Classifications for Necrotizing Fasciitis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt, 27ICD9CM, 25ICD10
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Classifications:



Aliases & Descriptions:

necrotizing fasciitis 8 42 10 60


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Disease Ontology8 DOID:9602
MeSH34 D019115
NCIt39 C84916
SNOMED-CT56 186428007, 52486002
ICD9CM27 728.86
ICD1025 M72.6

Related Diseases for Necrotizing Fasciitis

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to necrotizing fasciitis

Clinical Features for Necrotizing Fasciitis

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Drugs & Therapeutics for Necrotizing Fasciitis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Necrotizing Fasciitis

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Anatomical Context for Necrotizing Fasciitis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Necrotizing Fasciitis:

32
Skin, Breast, Colon, Liver, Kidney, Tonsil, Spinal cord, Bone, Bone marrow, Myeloid, Small intestine, Pancreas, Heart

Animal Models for Necrotizing Fasciitis or affiliated genes

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Publications for Necrotizing Fasciitis

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50PubMed
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Articles related to Necrotizing Fasciitis:

(show top 50)    (show all 556)
idTitleAuthorsYear
1
Bilateral necrotizing fasciitis of the breast following quadrantectomy. (20814771)
2014
2
Ludwig angina progressing to fatal necrotizing fasciitis. (23532644)
2013
3
A unique case of penile necrotizing fasciitis secondary to spontaneous corpus cavernosal abscess. (24198996)
2013
4
Necrotizing cervical fasciitis: Prognosis based on a new grading system. (23532652)
2013
5
Case report of orbital cellulitis and necrotizing fasciitis from melioidosis. (23303132)
2013
6
Vibrio vulnificus necrotizing fasciitis preceding herpes zoster. (23382617)
2013
7
Necrotizing fasciitis caused by methicillin-resistant Staphylococcus pseudintermedius at a previously irradiated site in a dog. (23633717)
2012
8
Necrotizing Fasciitis Associated with Staphylococcus lugdunensis. (22675644)
2012
9
Necrotizing fasciitis: classification, diagnosis, and management. (22491537)
2012
10
Microbiology and surgical indicators of necrotizing fasciitis in a tertiary hospital of southwest Taiwan. (22154593)
2012
11
Necrotizing fasciitis of the thigh secondary to retroperitoneal abscess. (22475736)
2012
12
Primary necrotizing fasciitis of the breast: a case report and review of the literature. (22408223)
2012
13
Does spinal cord injury influence the mortality rate in patients with necrotizing fasciitis? (21946443)
2012
14
Necrotizing fasciitis caused by Aeromonas caviae. (23826556)
2012
15
An Unusual Presentation of Ludwig's Angina Complicated by Cervical Necrotizing Fasciitis: A Case Report and Review of the Literature. (22953129)
2012
16
Surgical management of axillary necrotizing fasciitis: a case report. (22211460)
2012
17
Transfer status: a risk factor for mortality in patients with necrotizing fasciitis. (21783216)
2011
18
Necrotizing fasciitis of face--our experience in its management. (22679050)
2011
19
Necrotizing fasciitis caused by Staphylococcus aureus: the emergence of methicillin-resistant strains. (21407055)
2011
20
Cervical-thoracic facial necrotizing fasciitis of odontogenic origin. (22183289)
2011
21
Necrotizing fasciitis after acupuncture in a patient with aplastic anemia. (21875353)
2011
22
Fatal necrotizing fasciitis following two suicide attempts with petroleum oil injection. (20694733)
2011
23
Rare case of disseminated neonatal zygomycosis mimicking necrotizing enterocolitis with necrotizing fasciitis. (22008359)
2011
24
Adapting a Vacuum Assisted Closure dressing to challenging wounds: negative pressure treatment for perineal necrotizing fasciitis with rectal prolapse in a newborn affected by acute myeloid leukaemia. (20406723)
2010
25
Molecular pathogenesis of necrotizing fasciitis. (19737105)
2010
26
Hospital epidemiology of emergent cervical necrotizing fasciitis. (20606787)
2010
27
Cervical necrotizing fasciitis originating with a periapical infection. (20592406)
2010
28
Necrotizing fasciitis complicating female genital mutilation: case report. (20799561)
2010
29
A difficult case of necrotizing fasciitis caused by Acinetobacter baumannii. (21134952)
2010
30
Fulminant necrotizing fasciitis following the use of herbal concoction: a case report. (20958957)
2010
31
Necrotizing fasciitis of the chest wall. (20019031)
2010
32
Necrotizing fasciitis and myonecrosis "synergistic necrotizing cellulitis" caused by Bacillus cereus. (19583692)
2009
33
Prevalence of necrotizing fasciitis during Ramadan and Hajj 1427-H. (20364760)
2009
34
Necrotizing fasciitis of the face: a life-threatening condition. (19959927)
2009
35
Fungal periorbital necrotizing fasciitis in an immunocompetent adult. (19617805)
2009
36
Early diagnosis of necrotizing fasciitis with soft tissue ultrasound. (19732035)
2009
37
Case reports: fatal necrotizing fasciitis caused by Aeromonas sobria in two diabetic patients. (18800212)
2009
38
Fulminant epiglottitis with evolution to necrotizing soft tissue infections and fasciitis due to Aeromonas hydrophila. (18165860)
2008
39
Necrotizing fasciitis and sepsis caused by Aeromonas hydrophila after crush injury of the lower extremity. (18687029)
2008
40
Necrotizing fasciitis of the shoulder following routine rotator cuff repair. A case report. (18451406)
2008
41
Hyperbaric oxygen in necrotizing fasciitis. (19050570)
2008
42
Use of drotrecogin alfa in necrotizing fasciitis: a case report and pharmacologic review. (18805858)
2008
43
Necrotizing fasciitis of the breast. (18971695)
2008
44
Acute necrotizing fasciitis in Egyptian patients: a case series. (18234571)
2008
45
Necrotizing fasciitis: reviewing the causes and treatment strategies. (17473566)
2007
46
Necrotizing fasciitis: case report and review of literature. (17405595)
2007
47
Necrotizing Fasciitis of the Skull Base and Neck in a Patient with AIDS and Non-Hodgkin's Lymphoma. (17471319)
2006
48
Diagnosis and treatment of necrotizing fasciitis in the head and neck region. (18088660)
2003
49
Post-varicella epiglottitis and necrotizing fasciitis. (10617750)
2000
50
Unusual surgical infections. Gas gangrene necrotizing fasciitis phycomycosis synergistic bacterial gangrene. (5384660)
1969

Genetic Variations for Necrotizing Fasciitis

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Expression for genes affiliated with Necrotizing Fasciitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Necrotizing Fasciitis

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Pathways for genes affiliated with Necrotizing Fasciitis

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Compounds for genes affiliated with Necrotizing Fasciitis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Necrotizing Fasciitis according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.4PIK3C2A
2monoethylglycinexylidide4410.3GPT, F5
3ximelagatran44 1111.2GPT, F5
4acarbose44 1111.2GPT, INS
5desogestrel44 1111.2INS, F5
6hind iii4410.1CD46, F5
7policosanol4410.1GPT, PIK3C2A
8alpha-hydroxybutyrate4410.1GPT, PIK3C2A
9nash4410.1GPT, INS
10p-0074410.0PIK3C2A, GPT
11glycogen44 2411.0INS, PIK3C2A
12cyproteroneacetate449.9INS, F5
13metformin44 49 1111.9GPT, INS, F5
14gemfibrozil44 28 1111.7GPT, INS, PIK3C2A
15bezafibrate44 28 1111.7GPT, INS, PIK3C2A
16malondialdehyde449.7PIK3C2A, F5, GPT
17ezetimibe44 1110.7GPT, INS
18fenofibrate44 49 1111.7PIK3C2A, INS, GPT
19vitamin-e449.7GPT, F5, PIK3C2A
20tacrolimus44 49 1111.7F5, INS, GPT
21atorvastatin44 49 28 11 2413.7PIK3C2A, F5, GPT
22urea44 11 2411.6GPT, F5, PIK3C2A
23cocaine44 1110.6PIK3C2A, F5, GPT
24penicillin449.6IGHE, F5
25simvastatin44 49 59 28 11 2414.5GPT, F5, PIK3C2A, NPHS1
26succinylcholine44 28 1111.5PIK3C2A, IGHE
27uric acid44 2410.4GPT, INS, F5, PIK3C2A
28acetaminophen44 2 49 11 2413.4F5, IGHE, GPT
29protamine449.4F5, IGHE, INS
30fibrinogen449.4GPT, INS, F5, PIK3C2A
31isoflurane44 1110.4GPT, PIK3C2A
32cyclophosphamide44 49 1111.3CD46, IGHE, F5
33hydrocortisone44 2 59 1112.3INS, IGHE, F5
34ivig449.2GPT, IGHE, PIK3C2A
35heroin44 49 1111.2IGHE, PIK3C2A
36prednisolone44 28 1111.2GPT, IGHE, PIK3C2A
37choline44 11 2411.1GPT, IGHE, PIK3C2A
38aspartate449.1PIK3C2A, IGHE, GPT
39pge1449.0PIK3C2A, F5, IGHE, GPT
40glycerol44 11 2410.9INS, IGHE, PIK3C2A
41thyroxine44 249.9PIK3C2A, IGHE, INS, GPT
42cyclosporin a44 28 5910.9GPT, CD46, IGHE, PIK3C2A
43epinephrine44 11 2410.9PIK3C2A, F5, IGHE, INS
44methotrexate44 49 1110.8PIK3C2A, IGHE, GPT
45lactate448.6PIK3C2A, F5, IGHE, INS, GPT
46glutamate448.5PIK3C2A, F5, IGHE, INS, GPT
47testosterone44 59 11 2411.5INS, IGHE, F5, PIK3C2A
48alanine448.3PIK3C2A, F5, IGHE, CD46, INS, GPT
49creatinine448.3GPT, INS, IGHE, F5, PIK3C2A, NPHS1
50arginine448.3NPHS1, PIK3C2A, F5, IGHE, INS, GPT

GO Terms for genes affiliated with Necrotizing Fasciitis

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Products for genes affiliated with Necrotizing Fasciitis

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  • Antibodies
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Sources for Necrotizing Fasciitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet