Aliases & Classifications for Necrotizing Fasciitis

Aliases & Descriptions for Necrotizing Fasciitis:

Name: Necrotizing Fasciitis 12 50 3 14 69
Fasciitis, Necrotizing 42

Classifications:



External Ids:

Disease Ontology 12 DOID:9602
ICD10 33 M72.6
ICD9CM 35 728.86
MeSH 42 D019115
NCIt 47 C84916
SNOMED-CT 64 186428007 52486002
UMLS 69 C0238124

Summaries for Necrotizing Fasciitis

NIH Rare Diseases : 50 necrotizing fasciitis is a serious infection of the skin, the tissue just beneath the skin (subcutaneous tissue), and the tissue that covers internal organs (fascia). necrotizing fasciitis can be caused by several different types of bacteria, and the infection can arise suddenly and spread quickly. early signs include flu-like symptoms and redness and pain around the infection site. a prompt diagnosis and treatment are essential. if the infection is not treated promptly, it can lead to multiple organ failure and death. treatment typically includes intravenous (iv) antibiotics and surgery to remove infected and dead tissue. last updated: 4/12/2016

MalaCards based summary : Necrotizing Fasciitis, also known as fasciitis, necrotizing, is related to rheumatoid arthritis and fournier gangrene, and has symptoms including spasm and generalized muscle weakness. An important gene associated with Necrotizing Fasciitis is CD46 (CD46 Molecule), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Immunoglobulin G and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and breast, and related phenotype is cardiovascular system.

CDC : 3 Group A Streptococcus (group A strep) is a bacterium that can cause many different infections, including strep throat, scarlet fever, impetigo, and others. The bacteria live in the nose and throat. When someone who is infected coughs or sneezes, the bacteria travel in small droplets of water called respiratory droplets. One of the ways you can get sick is if you breathe in those droplets or if you touch something that has the droplets on it and then touch your mouth, nose, or eyes.

Wikipedia : 71 Necrotising fasciitis (NF), commonly known as flesh-eating disease, is an infection that results in the... more...

Related Diseases for Necrotizing Fasciitis

Diseases related to Necrotizing Fasciitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 195)
id Related Disease Score Top Affiliating Genes
1 rheumatoid arthritis 29.4 CXCL8 IL18 IL1RN IL2 IL6 LTA
2 fournier gangrene 11.4
3 fasciitis 11.0
4 cervicitis 10.4
5 oculomotor nerve paralysis 10.3 CXCL8 IL6
6 common peroneal nerve lesion 10.3 CXCL8 IL6
7 neonatal hypoxic and ischemic brain injury 10.3 CXCL8 IL6
8 acute gonococcal cystitis 10.2 CXCL8 IL18
9 psychotic disorder 10.2 CXCL8 IL6
10 chromophobe adenoma 10.2 CXCL8 IL2
11 egg allergy 10.2 IL18 IL1RN
12 coronary arterial fistulas 10.2 CXCL8 IL1RN
13 cutaneous sclerosis 10.2 IL1RN IL6
14 shoulder impingement syndrome 10.2 IL1RN IL6
15 pneumonia 10.2
16 toxic shock syndrome 10.2
17 schwannoma of ureter 10.2 CXCL8 IL6
18 retinal vascular disease 10.2 CXCL8 IL6
19 childhood electroclinical syndrome 10.2 CXCL8 IL6
20 kaposiform hemangioendothelioma 10.2 IL2 LTA
21 acute panmyelosis with myelofibrosis 10.2 CXCL8 IL6
22 fallopian tube carcinoma 10.2 CXCL8 IL2
23 drug dependence 10.2 IL6 LTA
24 acquired thrombocytopenia 10.2 CXCL8 IL18 IL6
25 allergic bronchopulmonary aspergillosis 10.2 CXCL8 IL18 IL6
26 lacrimal system cancer 10.2 CXCL8 IL18 IL6
27 plantar wart 10.2 CXCL8 IL2
28 benign neonatal seizures 10.2 IL18 IL1RN IL6
29 laryngotracheoesophageal cleft type 2 10.1 IL18 IL2 IL6
30 kidney leiomyosarcoma 10.1 IL1RN IL6
31 autosomal recessive type iv ehlers-danlos syndrome 10.1 CXCL8 IL1RN IL6
32 classic type lipoma 10.1 CXCL8 IL1RN IL6
33 esophagus lymphoma 10.1 CXCL8 IL6
34 labyrinthine bilateral reactive loss 10.1 CXCL8 IL2 IL6
35 histiocytosis 10.1 CXCL8 IL1RN IL6
36 thyroid hyalinizing trabecular adenoma 10.1 CXCL8 IL2 IL6
37 mediastinitis 10.1
38 intratubular embryonal carcinoma 10.1 CXCL8 IL1RN IL6
39 lichen disease 10.1 CXCL8 IL2 IL6
40 gastroduodenitis 10.1 CD46 IL2 IL6
41 pigmentation disease 10.1 CXCL8 IL2 IL6
42 detrusor sphincter dyssynergia 10.1 CXCL8 IL2 IL6
43 adnp syndrome 10.1 CXCL8 IL6 LTA
44 wagr syndrome 10.1 CXCL8 IL2 IL6
45 streptococcal toxic-shock syndrome 10.1
46 exophthalmos 10.1 CXCL8 IL2 IL6
47 retinal vascular occlusion 10.1 CXCL8 IL1RN LTA
48 collagenous colitis 10.1 CXCL8 IL2 IL6
49 necrotizing soft tissue infection 10.1
50 glycogen storage disease ix 10.1 CXCL8 IL18 IL6

Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to Necrotizing Fasciitis

Symptoms & Phenotypes for Necrotizing Fasciitis

UMLS symptoms related to Necrotizing Fasciitis:


spasm, generalized muscle weakness

MGI Mouse Phenotypes related to Necrotizing Fasciitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.23 CCNF CD46 IL18 IL1RN IL2 IL6

Drugs & Therapeutics for Necrotizing Fasciitis

Drugs for Necrotizing Fasciitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulin G Phase 2
2 Immunoglobulins Phase 2
3 gamma-Globulins Phase 2
4 Immunoglobulins, Intravenous Phase 2
5 Rho(D) Immune Globulin Phase 2
6 Antibodies Phase 2
7
Carbon monoxide Approved Phase 1 630-08-0 281
8
Azithromycin Approved 83905-01-5 55185 53477736 447043
9
Daptomycin Approved, Investigational 103060-53-3 16129629
10 Anti-Bacterial Agents
11 Anti-Infective Agents
12 Antibiotics, Antitubercular
13 Protein C

Interventional clinical trials:

(show all 20)
id Name Status NCT ID Phase
1 Negative Pressure Wound Therapy With the Engenex™-Pump and Bio-Dome™ Dressing, an Evaluation Unknown status NCT01107821 Phase 4
2 Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections Recruiting NCT02469857 Phase 3
3 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2
4 A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic Children Completed NCT00670891 Phase 1
5 Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus Infections Unknown status NCT01731483
6 Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing Fasciitis Completed NCT01739959
7 Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological Features Completed NCT01139112
8 Outcome and Related Factors of Necrotizing Fasciitis of the Limb Completed NCT00538577
9 Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections Completed NCT00261807
10 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
11 Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital Tract Completed NCT00299663
12 Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection Completed NCT01235546
13 Factors Associated With Complications of Cervical Necrotizing Fasciitis Recruiting NCT02847234
14 Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs). Recruiting NCT01790698
15 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
16 Genetic Susceptibility to Severe Streptococcal Infections Recruiting NCT01911572
17 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Recruiting NCT02501382
18 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352
19 Hyperglycemia in Surgical Infections Terminated NCT00353275
20 Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA) Withdrawn NCT00896402

Search NIH Clinical Center for Necrotizing Fasciitis

Cochrane evidence based reviews: fasciitis, necrotizing

Genetic Tests for Necrotizing Fasciitis

Anatomical Context for Necrotizing Fasciitis

MalaCards organs/tissues related to Necrotizing Fasciitis:

39
Skin, Eye, Breast, Colon, Liver, Kidney, Tonsil

Publications for Necrotizing Fasciitis

Articles related to Necrotizing Fasciitis:

(show top 50) (show all 675)
id Title Authors Year
1
Application of a Silicone Sheet in Negative-Pressure Wound Therapy to Treat an Abdominal Wall Defect after Necrotizing Fasciitis. ( 28194352 )
2017
2
Concurrent external and intraluminal vacuum-assisted closure in head and neck necrotizing fasciitis. ( 28084021 )
2017
3
Necrotizing Fasciitis in Aesthetic Surgery: A Review of the Literature. ( 28062962 )
2017
4
First case report of Nocardia brasiliensis infection causing necrotizing fasciitis in an immunocompetent patient. ( 27117138 )
2016
5
Pyoderma gangrenosum and necrotizing fasciitis-like opportunistic invasive cutaneous fungal infection. ( 27126743 )
2016
6
Bilateral Necrotizing Fasciitis of the Foot Associated with Group B Streptococcus. ( 27790114 )
2016
7
Skin-Sparing DAcbridement for Necrotizing Fasciitis in Children. ( 27556624 )
2016
8
A 10-Year Review of Necrotizing Fasciitis in the Pediatric Population: Delays to Diagnosis and Management. ( 27663964 )
2016
9
Evaluation of Factors Associated with Death in Patients with Necrotizing Fasciitis of the Abdominal Wall. ( 27929925 )
2016
10
It's Not Always What It Seems: Necrotizing Fasciitis Mimicking Angioedema. ( 27072731 )
2016
11
The Free-style Gluteal Perforator Flap in the Thinning and Delay Process for Perineal Reconstruction After Necrotizing Fasciitis. ( 27434419 )
2016
12
Diagnosis and Treatment of Pediatric Necrotizing Fasciitis: A Systematic Review of the Literature. ( 27380058 )
2016
13
Sequential necrotizing fasciitis caused by the monomicrobial pathogens Streptococcus equisimilis and extended-spectrum beta-lactamase-producing Escherichia coli. ( 26912298 )
2016
14
Ludwig's angina complicated by fatal cervicofascial and mediastinal necrotizing fasciitis. ( 27077024 )
2016
15
First report of monomicrobial Candida parapsilosis necrotizing fasciitis. ( 27385469 )
2016
16
Salvage therapy with intravenous fosfomycin plus ceftriaxone for necrotizing fasciitis caused by penicillin-nonsusceptible Streptococcus pneumoniae. ( 28082065 )
2016
17
What's new in emergencies, trauma and shock? The tortuous path in the management of necrotizing fasciitis: Is early surgical intervention critical? ( 26957818 )
2016
18
Cervical Necrotizing Fasciitis Caused by Dental Extraction. ( 27375905 )
2016
19
Triple diagnostics for early detection of ambivalent necrotizing fasciitis. ( 27766113 )
2016
20
Rare Complication of Stomas: Peristomal Necrotizing Fasciitis. ( 28054929 )
2016
21
A case report of necrotizing fasciitis of the abdominal wall: A rare, life-threatening complication of a common disease process. ( 27794239 )
2016
22
Successful Treatment of a Case of Necrotizing Fasciitis due to Vibrio vulnificus in a Cold Climate in Japan. ( 27086822 )
2016
23
Case Report of Necrotizing Fasciitis Associated with Streptococcus pneumoniae. ( 27366176 )
2016
24
Isolated digital necrotizing fasciitis: an unusual presentation. ( 27881796 )
2016
25
Necrotic fasciitis of the lateral muscle group of the thigh following outside-in transobturatory tape procedure. ( 27918157 )
2016
26
Necrotizing fasciitis of anterior abdominal wall following cesarean section in a low-risk patient. ( 27402541 )
2016
27
Necrotizing fasciitis associated with systemic lupus erythematosus in a child. ( 27626093 )
2016
28
Necrotizing Fasciitis of the Lower Extremity Caused by Serratia marcescens A Case Report. ( 27031553 )
2016
29
AA rare case of necrotizing fasciitis caused by Vibrio cholerae O8 in an immunocompetent patient. ( 27604649 )
2016
30
Necrotizing fasciitis in a patient receiving tocilizumab for rheumatoid arthritis - Case report. ( 28041910 )
2016
31
Necrotizing fasciitis due to Streptococcus mitis caused by accidental human bite. ( 26829544 )
2016
32
A Necrotizing Fasciitis Fake Out on Point-of-Care Ultrasound-Watch the Shadow. ( 27743718 )
2016
33
Pattern and predictors of mortality in necrotizing fasciitis patients in a single tertiary hospital. ( 27508002 )
2016
34
Ascending Facial Necrotizing Fasciitis in a Patient Taking a Bisphosphonate. ( 27639154 )
2016
35
Two non-otic cases of POM-1 metallo-I^-lactamase-producing Pseudomonas otitidis infection: Necrotizing fasciitis and pan-peritonitis. ( 27835844 )
2016
36
Impact of Intravenous Immunoglobulin on Survival in Necrotizing Fasciitis with Vasopressor-dependent Shock: A Propensity-Score Matched Analysis from 130 US Hospitals. ( 28034881 )
2016
37
The diagnosis you wish you had never operated on: Pyoderma gangrenosum misdiagnosed as necrotizing fasciitis-a case report. ( 27875063 )
2016
38
Nonodontogenic Cervical Necrotizing Fasciitis Caused by Sialadenitis. ( 27822398 )
2016
39
Odontogenic cervical necrotizing fasciitis, etiological aspects. ( 27022806 )
2016
40
Assessment of Administrative Medical Claims Data for Public Health Surveillance of Invasive Group A Streptococcal Necrotizing Fasciitis in Tennessee. ( 27453600 )
2016
41
Sonographic Findings in Necrotizing Fasciitis: Two Ends of the Spectrum. ( 27582527 )
2016
42
Primary Necrotizing Fasciitis of the Breast in an Untreated Patient with Diabetes. ( 27896201 )
2016
43
Necrotizing Fasciitis Presenting as an Itchy Thigh. ( 27579187 )
2016
44
Necrotizing fasciitis due to Vibrio cholerae non-O1/non-O139 after exposure to Austrian bathing sites. ( 26825075 )
2016
45
Fatal Fulminant Retroperitoneal Necrotizing Fasciitis Caused by Streptococcus viridans. ( 27097613 )
2016
46
Flow-through Instillation of Hypochlorous Acid in the Treatment of Necrotizing Fasciitis. ( 26891136 )
2016
47
Comment on: "Cervical Necrotizing Fasciitis-The Value of the Laboratory Risk Indicator for Necrotizing Fasciitis Score as an Indicative Parameter". ( 26963076 )
2016
48
Necrotizing Fasciitis as a Complication of a Continuous Sciatic Nerve Catheter Using the Lateral Popliteal Approach. ( 27662064 )
2016
49
Necrotizing fasciitis associated with systemic lupus erythematosus in a child. ( 27559515 )
2016
50
Synchronous multifocal necrotizing fasciitis prognostic factors: a retrospective case series study in a single center. ( 27778190 )
2016

Variations for Necrotizing Fasciitis

Expression for Necrotizing Fasciitis

Search GEO for disease gene expression data for Necrotizing Fasciitis.

Pathways for Necrotizing Fasciitis

Pathways related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 28)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.8 CCNF CD46 CXCL8 IL18 IL1RN IL2
2
Show member pathways
13.14 CXCL8 IL18 IL1RN IL2 IL6 LTA
3
Show member pathways
13.09 CXCL8 IL18 IL2 IL6 LTA
4
Show member pathways
12.63 CXCL8 IL2 IL6 LTA
5
Show member pathways
12.43 CD46 CXCL8 IL18 IL2 IL6 LTA
6 11.97 CXCL8 IL1RN IL6
7 11.82 CXCL8 IL2 IL6
8 11.79 CXCL8 IL18 IL6
9 11.68 CXCL8 IL18 IL2
10 11.65 CXCL8 IL18 IL6
11
Show member pathways
11.65 IL18 IL2 IL6 LTA
12 11.62 CXCL8 IL18 IL6
13
Show member pathways
11.59 CXCL8 IL2 LTA
14 11.57 CXCL8 IL2 IL6
15 11.54 IL18 IL2 LTA
16
Show member pathways
11.41 CXCL8 IL2 IL6
17 11.32 CXCL8 IL18 IL6
18 11.23 CXCL8 IL18 IL6
19
Show member pathways
11.23 CXCL8 IL18 IL2 IL6 LTA
20 11.18 IL18 IL6
21 11.16 CXCL8 IL6
22 11.13 IL18 IL6
23 11.09 IL2 IL6
24 11.06 IL18 IL2
25 11.02 IL2 LTA
26 10.95 CXCL8 IL18 IL1RN IL6
27 10.85 CXCL8 IL6
28 10.78 CXCL8 IL18 IL2 IL6 LTA

GO Terms for Necrotizing Fasciitis

Cellular components related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Biological processes related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.8 CXCL8 IL18 IL1RN IL6
2 positive regulation of activated T cell proliferation GO:0042104 9.52 IL18 IL2
3 natural killer cell activation GO:0030101 9.51 IL18 IL2
4 positive regulation of T cell proliferation GO:0042102 9.5 CD46 IL2 IL6
5 positive regulation of interleukin-17 production GO:0032740 9.48 IL18 IL2
6 positive regulation of immunoglobulin secretion GO:0051024 9.46 IL2 IL6
7 positive regulation of regulatory T cell differentiation GO:0045591 9.43 CD46 IL2
8 positive regulation of T-helper 2 cell differentiation GO:0045630 9.4 IL18 IL6
9 positive regulation of tissue remodeling GO:0034105 9.37 IL18 IL2
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.33 IL18 IL2 IL6
11 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.26 IL1RN IL6
12 positive regulation of interferon-gamma production GO:0032729 9.13 IL18 IL2 LTA
13 immune response GO:0006955 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Molecular functions related to Necrotizing Fasciitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CXCL8 IL18 IL1RN IL2 IL6 LTA

Sources for Necrotizing Fasciitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....