MCID: NCR007
MIFTS: 32

Necrotizing Fasciitis malady

Category: Rare diseases

Aliases & Classifications for Necrotizing Fasciitis

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Aliases & Descriptions for Necrotizing Fasciitis:

Name: Necrotizing Fasciitis 10 45 12 2 65
 
Fasciitis, Necrotizing 36 2

Classifications:



External Ids:

Disease Ontology10 DOID:9602
ICD1027 M72.6
ICD9CM29 728.86
SNOMED-CT59 186428007, 52486002
MeSH36 D019115
NCIt42 C84916
UMLS65 C0238124

Summaries for Necrotizing Fasciitis

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NIH Rare Diseases:45 Necrotizing fasciitis is a serious infection of the skin, subcutaneous tissue (tissue just beneath the skin) and fascia. the infection can arise suddenly and spread quickly. necrotizing fasciitis can be caused by several different types of bacteria. early signs include flu-like symptoms and redness and pain around the infection site. if the infection is not treated promptly, it can lead to multiple organ failure and death. as a result, prompt diagnosis and treatment is essential. treatment typically includes intravenous antibiotics and surgery to remove infected and dead tissue. last updated: 4/12/2016

MalaCards based summary: Necrotizing Fasciitis, also known as fasciitis, necrotizing, is related to fournier gangrene and hepatitis. An important gene associated with Necrotizing Fasciitis is CD46 (CD46 Molecule). Affiliated tissues include skin, eye and lung.

CDC:2 Group A Streptococcus (group A strep, GAS) bacteria can live in a person's nose and throat. The bacteria are spread through contact with droplets from an infected person's cough or sneeze. If you touch your mouth, nose, or eyes after touching something that has these droplets on it, you may become ill. If you drink from the same glass or eat from the same plate as the sick person, you could also become ill. It is also possible for group A strep bacteria to spread from contact with sores from a group A strep skin infection.

Wikipedia:68 Necrotising fasciitis (NF), commonly known as flesh-eating disease, is a rare infection (0.04 cases per... more...

Related Diseases for Necrotizing Fasciitis

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Graphical network of the top 20 diseases related to Necrotizing Fasciitis:



Diseases related to necrotizing fasciitis

Symptoms for Necrotizing Fasciitis

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Drugs & Therapeutics for Necrotizing Fasciitis

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Drugs for Necrotizing Fasciitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Immunologic FactorsPhase 218483
2AntibodiesPhase 24477
3Immunoglobulins, IntravenousPhase 2211
4Rho(D) Immune GlobulinPhase 2206
5Immunoglobulin GPhase 2146
6ImmunoglobulinsPhase 24477
7
Carbon monoxidePhase 1102281
Synonyms:
 
CO
Carbon monoxide
8
Daptomycinapproved, investigational83103060-53-316129629
Synonyms:
103060-53-3
AKOS005146218
C12013
C72H101N17O26
CHEBI:600103
CHEMBL508162
Cidecin
Cubicin
Cubicin (TN)
D01080
DAPTOMYCIN
Dapcin
Daptomicina
Daptomicina [Spanish]
Daptomycin
Daptomycin (JAN/USAN/INN)
Daptomycin [USAN:INN:BAN]
Daptomycine
 
Daptomycine [French]
Daptomycinum
Daptomycinum [Latin]
Deptomycin
LS-171846
LY 146032
LY-146032
LY146032
MK-3009
MolPort-003-846-138
N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine 1.13-3.4-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon(1)-lactone
N-decanoyl-L-tryptophyl-D-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-ox
N-decanoyl-L-tryptophyl-L-asparaginyl-N-[(3S,6S,9R,15S,18R,21S,24S,30S,31R)-3-[2-(2-aminophenyl)-2-oxoethyl]-24-(3-aminopropyl)-15,21-bis(carboxymethyl)-6-[(2R)-1-carboxypropan-2-yl]-9-(hydroxymethyl)-18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontan-30-yl]-L-alpha-asparagine
UNII-NWQ5N31VKK
daptomycin
nchembio.184-comp5
9
Azithromycinapproved32283905-01-555185, 53477736, 447043
Synonyms:
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-b-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-11-{[3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy}-1-oxa-6-azacyclopentadecan-13-yl 2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranoside
(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)13-((2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-1-oxa-6-azacyclopentadecan-15-one
1-Oxa-6-azacyclopentadecan-15-one, 13-((2,6-dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy)-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-((3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl)oxy)-,(2R-(2R*,3S*
121470-24-4
75199_FLUKA
83905-01-5
9-Deoxo-9a-aza-9a-methyl-9a-homoerythromycin A
AC-16014
AC1L9KEG
Aritromicina
Azasite
Azenil
Azifast
Azigram
Azimakrol
Azithramycine
Azithromycin
Azithromycin & Tumor Necrosis Factor
Azithromycin (AIDS Initiative)
Azithromycin (anhydrous)
Azithromycin Dihydrate
Azithromycin Monohydrate
Azithromycin Sterile
Azithromycin dihydrate
Azithromycin plus Tumor Necrosis Factor
Azithromycine
Azithromycine [French]
Azithromycinum
Azithromycinum [Latin]
Azitrocin
Azitromax
Azitromicina
Azitromicina [Spanish]
Azitromin
Azythromycin
BIDD:GT0792
BRN 5387583
BSPBio_002285
Bio-0676
C38H72N2O12
CCRIS 1961
CHEBI:2955
CHEMBL529
CID447043
CP-62993
CP62,993
CPD000471864
DCH3
DRG-0104
 
DivK1c_000233
HMS1922G12
HMS2094M11
HMS500L15
HSDB 7205
Hemomycin
IDI1_000233
KBio1_000233
KBio2_000787
KBio2_003355
KBio2_005923
KBio3_001505
KBioGR_000731
KBioSS_000787
LS-1834
MLS001055353
MLS001066331
MLS001201763
MLS001304005
MLS001332499
MLS001332500
Misultina
MolPort-002-507-426
N,N-Dimethyl-4-amino-benzaldehyde
NCGC00090753-01
NCGC00090753-02
NINDS_000233
NSC643732
SAM002589961
SMR000471864
SPBio_001544
SPECTRUM1503679
Spectrum2_001582
Spectrum3_000653
Spectrum4_000186
Spectrum5_001867
Spectrum_000307
Sumamed
Tromix
UNII-JTE4MNN1MD
XZ-450
Z-Pak
ZIT
Zentavion
Zithromac
Zithromax
Zithromax IV
Zithromycin
Zitromax
Zitromax Avium 600
Zmas
Zmax
azithromycin
10Antibiotics, Antitubercular5971
11Anti-Bacterial Agents9140
12Anti-Infective Agents17220

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Negative Pressure Wound Therapy With the Engenex™-Pump and Bio-Dome™ Dressing, an EvaluationRecruitingNCT01107821Phase 4
2Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue InfectionsRecruitingNCT02469857Phase 3
3Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled TrialActive, not recruitingNCT02111161Phase 2
4A Clinical Trial of the Clinical Effects of Hyperbaric Oxygen Therapy in Thai Autistic ChildrenCompletedNCT00670891Phase 1
5Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing FasciitisCompletedNCT01739959
6Klebsiella Pneumoniae Necrotizing Fasciitis: Clinical and Microbiological FeaturesCompletedNCT01139112
7Outcome and Related Factors of Necrotizing Fasciitis of the LimbCompletedNCT00538577
8Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue InfectionsCompletedNCT00261807
9Biomarkers in Patients With Flesh-eating Bacterial InfectionsCompletedNCT02180906
10Long Term Follow-up of Patients With Group A Streptococcal Infection Originating From the Genital TractCompletedNCT00299663
11Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean InfectionCompletedNCT01235546
12Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs).RecruitingNCT01790698
13Genetic Susceptibility to Severe Streptococcal InfectionsRecruitingNCT01911572
14Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen TreatmentRecruitingNCT02501382
15Severe Soft Tissue Infections: Perspectives of Patients and Significant OthersRecruitingNCT02169128
16Coagulation and Fibrinolysis as Virulence Factors for Invasive Staphylococcus Aureus and Streptococcus InfectionsRecruitingNCT01731483
17Hyperglycemia in Surgical InfectionsTerminatedNCT00353275
18Chlorhexidine Versus Betadine in Preventing Colonization of Femoral Nerve Catheters After Total Joint Arthroplasty (TJA)WithdrawnNCT00896402

Search NIH Clinical Center for Necrotizing Fasciitis


Cochrane evidence based reviews: fasciitis, necrotizing

Genetic Tests for Necrotizing Fasciitis

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Anatomical Context for Necrotizing Fasciitis

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MalaCards organs/tissues related to Necrotizing Fasciitis:

33
Skin, Eye, Lung, Breast, Brain, T cells, Prostate

Animal Models for Necrotizing Fasciitis or affiliated genes

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MGI Mouse Phenotypes related to Necrotizing Fasciitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Necrotizing Fasciitis

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Articles related to Necrotizing Fasciitis:

(show top 50)    (show all 612)
idTitleAuthorsYear
1
Churg-Strauss syndrome associated with antiphospholipid antibodies in a patient with retinal vasculitis. (27068137)
2016
2
PO-07 - Excluding pulmonary embolism in cancer patients using the Wells rule and age-adjusted D-dimer testing: an individual patient data meta-analysis. (27161697)
2016
3
Congenital adrenal hyperplasia patient perception of 'disorders of sex development' nomenclature. (25780368)
2015
4
Clinical features of 280 hospitalized patients with lymphangioleiomyomatosis in Japan. (25385157)
2014
5
Sexual dysfunctions and psychological disorders associated with type IIIa chronic prostatitis: a clinical survey in China. (25158893)
2014
6
DNA methylation aberrations rather than polymorphisms of FZD3 gene increase the risk of spina bifida in a high-risk region for neural tube defects. (25131656)
2014
7
MicroRNA 181a improves proliferation and invasion, suppresses apoptosis of osteosarcoma cell. (23740615)
2013
8
The application of vizilite in oral cancer. (23450083)
2013
9
Hospitalisation rates for pneumonia following the introduction of a pneumococcal vaccination. (24043635)
2013
10
Development of pyloric stenosis after a 4-day course of oral erythromycin. (23558266)
2013
11
Choroidal Metastases Responsive to Crizotinib Therapy in a Lung Adenocarcinoma Patient with ALK 2p23 Fusion Identified by ALK Immunohistochemistry. (24389446)
2013
12
5'-Triphosphate-short interfering RNA: potent inhibition of influenza A virus infection by gene silencing and RIG-I activation. (22787226)
2012
13
The first descriptions of syringomyelia. (22843644)
2012
14
SNP rs2470152 in CYP19 is correlated to aromatase activity in Chinese polycystic ovary syndrome patients. (21972004)
2012
15
Interaction of GAPR-1 with lipid bilayers is regulated by alternative homodimerization. (22560898)
2012
16
Letter to the editor regarding JAPrg Christoph Prinz et al. "The Nessos shirt: did Herakles die from scleroderma?" in J Dtsch Dermatol Ges 2011; 9: 336-7. (21910264)
2011
17
Functional KCa3.1 K+ channels are required for human fibrocyte migration. (21872912)
2011
18
Gait variability of patients with intermittent claudication is similar before and after the onset of claudication pain. (21450380)
2011
19
Surgical treatment for scoliosis in patients with Shprintzen-Goldberg syndrome. (21307714)
2011
20
Increasing tPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse. (20140248)
2010
21
Cellular pathophysiological consequences of BCS1L mutations in mitochondrial complex III enzyme deficiency. (20518024)
2010
22
Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth. (19610136)
2009
23
An unusual cause of obstructive jaundice. (21686538)
2009
24
Plasma biomarkers of acute attacks in patients with angioedema due to C1-inhibitor deficiency. (19076541)
2009
25
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP. (18218782)
2008
26
Hyporeninemic hypoaldosteronism from secondary amyloidosis. (18670413)
2008
27
Glibenclamide exerts an antitumor activity through reactive oxygen species-c-jun NH2-terminal kinase pathway in human gastric cancer cell line MGC-803. (18840412)
2008
28
Antibody array-generated cytokine profiles of tears of patients with vernal keratoconjunctivitis or giant papillary conjunctivitis. (16767372)
2006
29
Interleukin-10 promoter polymorphisms in male and female fertility and fecundity. (17051272)
2006
30
Dynamic association and localization of human H/ACA RNP proteins. (17135485)
2006
31
Advances in therapy for ascites and hepatorenal syndrome]. (15650969)
2005
32
Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease. (15068971)
2004
33
Effects of gene dosage, promoters, and substrates on unfolded protein stress of recombinant Pichia pastoris. (14755554)
2004
34
Autoregulatory role of interleukin-10 in hepatitis C patients treated with IFN-alpha. (15626155)
2004
35
Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus. (15638460)
2004
36
Arsenite stimulated glucose transport in 3T3-L1 adipocytes involves both Glut4 translocation and p38 MAPK activity. (14511371)
2003
37
Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimics. (12456321)
2003
38
Simple method for screening Candida species isolates for the presence of secreted proteinases: a tool for the prediction of successful inhibitory treatment. (12574271)
2003
39
Bystander transfer of functional human CD40 ligand from gene-modified fibroblasts to B-chronic lymphocytic leukemia cells. (12718765)
2003
40
Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway. (12730237)
2003
41
Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women. (11791143)
2002
42
Addition of a single gp120 glycan confers increased binding to dendritic cell-specific ICAM-3-grabbing nonintegrin and neutralization escape to human immunodeficiency virus type 1. (12239306)
2002
43
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. (12477941)
2002
44
Nonfunctional parathyroid carcinoma. (11491274)
2001
45
Tumor escaping mechanisms present in microenvironment of laryngeal cancer]. (15852789)
2001
46
Laryngeal amyloidosis with laryngocele: MRI and CT. (9689634)
1998
47
A human ubiquitin conjugating enzyme, L-UBC, maps in the Alzheimer's disease locus on chromosome 14q24.3. (8563171)
1995
48
Allergic contact cheilitis from a lipstick containing oxybenzone. (1451504)
1992
49
III. TOLERANCE FOR MERCURY POISONING INCREASED BY FREQUENT HEMOGLOBIN INJECTIONS. (19870018)
1932
50

Variations for Necrotizing Fasciitis

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Expression for genes affiliated with Necrotizing Fasciitis

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Search GEO for disease gene expression data for Necrotizing Fasciitis.

Pathways for genes affiliated with Necrotizing Fasciitis

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GO Terms for genes affiliated with Necrotizing Fasciitis

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Sources for Necrotizing Fasciitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet