MCID: NCR003
MIFTS: 35

Necrotizing Sialometaplasia malady

Oral diseases category

Aliases & Classifications for Necrotizing Sialometaplasia

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Aliases & Descriptions for Necrotizing Sialometaplasia:

Name: Necrotizing Sialometaplasia 10 12
 
Sialometaplasia, Necrotizing 65 36


Classifications:



External Ids:

Disease Ontology10 DOID:12901
SNOMED-CT59 109769000
MeSH36 D012797

Summaries for Necrotizing Sialometaplasia

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Wikipedia:68 Necrotizing sialometaplasia (NS) is a benign, ulcerative lesion, usually located towards the back of the... more...

MalaCards based summary: Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to gastric adenosquamous carcinoma and malignant hypertension. An important gene associated with Necrotizing Sialometaplasia is KRT5 (Keratin 5, Type II), and among its related pathways are TP53 network and Glucocorticoid receptor regulatory network. Affiliated tissues include salivary gland, t cells and trachea, and related mouse phenotypes are digestive/alimentary and limbs/digits/tail.

Related Diseases for Necrotizing Sialometaplasia

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Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 161)
idRelated DiseaseScoreTop Affiliating Genes
1gastric adenosquamous carcinoma10.4KRT5, TP53
2malignant hypertension10.3ACTC1, TP53
3brain germinoma10.3MKI67, TP53
4cowden disease10.3ACTC1, TP53
5echinococcosis10.3KRT5, TP53
6pilar sheath acanthoma10.3KRT5, KRT7
7vulva basal cell carcinoma10.3KRT7, TP63
8central nervous system leiomyosarcoma10.3MKI67, TP53
9splenogonadal fusion limb defects micrognatia10.3MKI67, TP53
10amelogenesis imperfecta hypomaturation type10.3MKI67, TP63
11coronary aneurysm10.3KRT5, KRT7
12mixed cell type adenoma of parathyroid10.3KRT7, MKI67
13placental site trophoblastic tumor10.3ACTC1, MKI67
14basal cell carcinoma 710.3ACTC1, TP53
15pediatric cns choriocarcinoma10.3ACTC1, TP63
16breast leiomyoma10.3KRT5, TP63
17benign multicystic peritoneal mesothelioma10.3ACTC1, KRT7
18monocular esotropia10.3KRT5, KRT7
19microcystic variant infiltrating bladder urothelial carcinoma10.3ACTC1, KRT7
20lens-induced iridocyclitis10.3MIB1, TP53
21schwannian stroma-rich and stroma-poor composite ganglioneuroblastoma10.3KRT7, MIB1
22cervicitis10.3KRT7, MIB1
23ampullary signet ring cell adenocarcinoma10.3KRT5, TP53, TP63
24childhood cerebral astrocytoma10.3GFAP, TP53
25anaplastic oligoastrocytoma10.3ACTC1, GFAP
26steatitis10.3KRT5, MKI67, TP53
27fallopian tube clear cell adenocarcinoma10.3KRT5, KRT7, TP53
28iridocyclitis10.3KRT5, MKI67, TP53
29monophasic synovial sarcoma10.3GFAP, TP53
30pineal region yolk sac tumor10.3ACTC1, KRT5, TP63
31oral lichen planus10.3MKI67, TP53
32endocrine exophthalmos10.3MIB1, TP53
33cerebellopontine angle tumor10.3GFAP, TP53
34vulvar benign neoplasm10.2MIB1, TP53
35kidney leiomyosarcoma10.2ACTC1, GFAP
36brachydactyly - arterial hypertension10.2KRT5, KRT7, TP53
37central nervous system sarcoma10.2GFAP, TP53
38small cell sarcoma10.2GZMB, TIA1
39cerebral arterial disease10.2GFAP, TP53
40lysosomal storage disease10.2GZMB, TIA1
41gallbladder mucinous carcinoma10.2KRT5, KRT7, TP53
42charcot-marie-tooth disease10.2MKI67, TP53, TP63
43breast cystic hypersecretory carcinoma10.2MKI67, TP53, TP63
44bronchial disease10.2KRT5, MIB1
45graphite pneumoconiosis10.2ACTC1, KRT7, TP53
46epidemic typhus10.2GFAP, TP53
47bone peripheral neuroepithelioma10.2KRT5, TIA1, TP53
48lung oat cell carcinoma10.2ACTC1, GFAP
49vulvar seborrheic keratosis10.2KRT7, MKI67, TP53
50rosette-forming glioneuronal tumor of fourth ventricule10.2GFAP, TP53

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to necrotizing sialometaplasia

Symptoms for Necrotizing Sialometaplasia

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Drugs & Therapeutics for Necrotizing Sialometaplasia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Necrotizing Sialometaplasia


Cochrane evidence based reviews: Sialometaplasia, Necrotizing

Genetic Tests for Necrotizing Sialometaplasia

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Anatomical Context for Necrotizing Sialometaplasia

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MalaCards organs/tissues related to Necrotizing Sialometaplasia:

33
Salivary gland, T cells, Trachea, Tongue, Testes, Breast

Animal Models for Necrotizing Sialometaplasia or affiliated genes

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MGI Mouse Phenotypes related to Necrotizing Sialometaplasia:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7GFAP, KIT, KRT5, MIB1, TP53, TP63
2MP:00053718.7KIT, KRT5, MAPK14, MIB1, TP53, TP63
3MP:00028737.8ACTC1, CD5, GFAP, KIT, MAPK14, MIB1
4MP:00053857.2ACTC1, CRTC1, GFAP, KIT, MAPK14, MIB1
5MP:00053847.1ACTC1, GFAP, GZMB, KIT, KRT7, MAPK14
6MP:00107686.9ACTC1, GFAP, GZMB, KIT, KRT5, MAPK14
7MP:00053976.9CD5, CRTC1, GZMB, KIT, MAPK14, MIB1
8MP:00053786.5ACTC1, CRTC1, GFAP, KIT, MAPK14, MIB1

Publications for Necrotizing Sialometaplasia

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Articles related to Necrotizing Sialometaplasia:

(show top 50)    (show all 155)
idTitleAuthorsYear
1
Necrotizing sialometaplasia related to vomiting and silastic ring vertical gastroplasty. (26504909)
2015
2
Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature. (24634907)
2014
3
Necrotizing sialometaplasia: a diagnostic dilemma. (25284537)
2014
4
Necrotizing sialometaplasia: A diagnostic dilemma! (25948999)
2014
5
Necrotizing sialometaplasia: A rare lesion that mimics oral cancer clinically and histopathologically. (24837912)
2014
6
Early references to necrotizing sialometaplasia. (24439923)
2014
7
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. (24353777)
2013
8
The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. (22921832)
2012
9
Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. (20403036)
2010
10
Necrotizing sialometaplasia: a practical approach to the diagnosis. (19415943)
2009
11
Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. (19482450)
2009
12
Case of the month. Necrotizing sialometaplasia. (18567189)
2008
13
Bilateral presentation of necrotizing sialometaplasia--a case report. (18087930)
2007
14
Necrotizing sialometaplasia: a potential diagnostic pitfall. (17044429)
2006
15
Necrotizing sialometaplasia: report of five cases. (15292869)
2004
16
Necrotizing sialometaplasia: a case report. (15503360)
2004
17
Subacute necrotizing sialadenitis: a form of necrotizing sialometaplasia? (12975270)
2003
18
A case of necrotizing sialometaplasia in the upper lip. (12970596)
2003
19
Oral pathology quiz #35. Case number 2. Necrotizing sialometaplasia. (16795953)
2002
20
Necrotizing sialometaplasia: report of a case after lower lip mucocele excision. (11117693)
2000
21
Oral pathology. Fall 1998 case of the month. Necrotizing sialometaplasia. (10596625)
1998
22
Necrotizing sialometaplasia: literature review and case reports. (8754467)
1996
23
Necrotizing sialometaplasia of the larynx. (8607453)
1996
24
Pathologic quiz case 1. Necrotizing sialometaplasia obscuring recurrent well-differentiated squamous cell carcinoma of the maxillary sinus. (7727094)
1995
25
Necrotizing sialometaplasia. (8084644)
1994
26
Necrotizing sialometaplasia (adenometaplasia) of the trachea. (8495967)
1993
27
Necrotizing sialometaplasia (adenometaplasia) of the trachea. (1398527)
1992
28
Necrotizing sialometaplasia of major salivary glands. (3668381)
1987
29
Necrotizing sialometaplasia--a malignancy simulating oral lesion. (3458319)
1986
30
Necrotizing sialometaplasia of the nasal cavity. (3083385)
1986
31
Necrotizing sialometaplasia obscuring an underlying malignancy: report of a case. (3459842)
1986
32
Necrotizing sialometaplasia of palatal minor salivary glands: a report on 2 cases. (3855981)
1985
33
Necrotizing sialometaplasia. (6829370)
1983
34
Necrotizing sialometaplasia: an early, nonulcerative presentation. (6952149)
1982
35
Necrotizing sialometaplasia. (7242209)
1981
36
Necrotizing sialometaplasia: literature review and presentation of five cases. (6944453)
1981
37
Necrotizing sialometaplasia in a patient with Buerger's disease and Raynaud's phenomenon. (6928308)
1980
38
Necrotizing sialometaplasia. (6951608)
1980
39
Necrotizing sialometaplasia: review of the literature and report of nonulcerative case. (286778)
1979
40
Necrotizing sialometaplasia. (285245)
1979
41
Necrotizing sialometaplasia: a result of ischemia? Report of two cases and review of the literature. (298661)
1979
42
Case for diagnosis. Necrotizing sialometaplasia, left hard palate. (113695)
1979
43
Necrotizing sialometaplasia affecting the minor labial glands. (284279)
1979
44
Necrotizing sialometaplasia. (299075)
1979
45
NECROTIZING SIALOMETAPLASIA. (269338)
1977
46
Necrotizing sialometaplasia of the palate. (1066464)
1976
47
Necrotizing sialometaplasia. (1075246)
1976
48
Necrotizing sialometaplasia. Report of a case. (1164230)
1975
49
Necrotizing sialometaplasia. Report of five additional cases. (4524380)
1974
50
Necrotizing sialometaplasia. A disease simulating malignancy. (4716764)
1973

Variations for Necrotizing Sialometaplasia

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Expression for genes affiliated with Necrotizing Sialometaplasia

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Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for genes affiliated with Necrotizing Sialometaplasia

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Pathways related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0TP53, TP63
29.5KRT5, MAPK14, TP53
3
Show member pathways
9.2GFAP, KRT5, KRT7
49.2ACTC1, KIT, MAPK14

GO Terms for genes affiliated with Necrotizing Sialometaplasia

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Cellular components related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.8GFAP, KRT5, KRT7
2cytoplasmGO:00057375.3ACTC1, CRTC1, GFAP, GZMB, KIT, KRT5

Biological processes related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.5TP53, TP63
2mitotic G1 DNA damage checkpointGO:003157110.0TP53, TP63
3entrainment of circadian clock by photoperiodGO:00431539.7CRTC1, TP53
4Notch signaling pathwayGO:00072199.3GZMB, MAML2, MIB1, TP53, TP63
5positive regulation of gene expressionGO:00106288.8ACTC1, KIT, MAPK14, TP53
6apoptotic processGO:00069158.2ACTC1, GZMB, MAPK14, TIA1, TP53, TP63

Sources for Necrotizing Sialometaplasia

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet