MCID: NCR003
MIFTS: 35

Necrotizing Sialometaplasia malady

Category: Oral diseases

Aliases & Classifications for Necrotizing Sialometaplasia

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Aliases & Descriptions for Necrotizing Sialometaplasia:

Name: Necrotizing Sialometaplasia 11 13
 
Sialometaplasia, Necrotizing 37 66

Classifications:



External Ids:

Disease Ontology11 DOID:12901
ICD1028 K11.8
SNOMED-CT60 109769000
MeSH37 D012797

Summaries for Necrotizing Sialometaplasia

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Wikipedia:69 Necrotizing sialometaplasia (NS) is a benign, ulcerative lesion, usually located towards the back of the... more...

MalaCards based summary: Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to peptic ulcer disease and mushroom workers' lung. An important gene associated with Necrotizing Sialometaplasia is KRT5 (Keratin 5), and among its related pathways are Inhibition of Ribosome Biogenesis by p14(ARF) and Activation of BH3-only proteins. Affiliated tissues include salivary gland, t cells and trachea, and related mouse phenotypes are muscle and no phenotypic analysis.

Related Diseases for Necrotizing Sialometaplasia

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Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1peptic ulcer disease10.9MKI67, TP53
2mushroom workers' lung10.8ACTC1, TP53
3cryptosporidiosis10.8KRT5, TP53
4placental site trophoblastic tumor10.8ACTC1, MKI67
5signet ring basal cell carcinoma10.7KRT7, TP63
6lacrimal gland mucoepidermoid carcinoma10.7KRT5, KRT7
7familial periodic paralysis10.7KRT5, KRT7
8epidermolytic acanthoma10.7KRT5, KRT7
9eccrine papillary adenoma10.7ACTC1, TP53
10mollaret meningitis10.7ACTC1, KRT7
11skin meningioma10.7GFAP, TP53
12female breast lower-inner quadrant cancer10.7KRT5, KRT7
13glomeruloid hemangioma10.7GFAP, TP53
14breast neuroendocrine neoplasm10.7KRT5, KRT7
15vulvar alveolar soft part sarcoma10.7ACTC1, TP63
16skin glomangioma10.7ACTC1, TP53
17infiltrating lipoma10.6GFAP, TP53
18renal pelvis inverted papilloma10.6GFAP, TP53
19brain glioma10.6GFAP, TP53
20vulvar benign neoplasm10.6GFAP, TP53
21anaplastic oligodendroglioma10.6ACTC1, GFAP
22hypersensitivity reaction type ii disease10.6GFAP, TP53
23brainstem intraparenchymal clear cell meningioma10.6GFAP, TP53
24yolk sac tumor of central nervous system10.6GFAP, TP53
25atypical choroid plexus papilloma10.6GFAP, TP53
26chondroblastoma10.6ACTC1, GFAP
27external ear disease10.6GFAP, TP53
28ganglioglioma10.6GFAP, TP53
29tamoxifen-related endometrial lesion10.6KRT5, KRT7, TP53
30pulmonary venoocclusive disease10.6ACTC1, GFAP
31male infertility10.6GZMB, TIA1
32eosinophilia10.6GZMB, TIA1
33subependymal nodular heterotopia10.5GZMB, TIA1
34pseudotyphus of california10.5GZMB, TIA1
35localized epiphyseal dysplasia10.5ACTC1, TP53, TP63
36plexopathy10.5GFAP, TP53
37granulomatous gastritis10.5GZMB, TIA1
38paranasal sinus cancer, adult10.5ACTC1, KRT7, TP53
39mast-cell sarcoma10.5KRT5, KRT7
40clivus chordoma10.5GZMB, TIA1
41diffuse large b-cell lymphoma with chronic inflammation10.5GZMB, TIA1
42polycystic ovary syndrome10.5GZMB, TIA1
43xq12-q13.3 duplication syndrome10.5ACTC1, KIT
44mucoepidermoid thyroid carcinoma10.5CRTC1, MAML2
45malignant pineal area germ cell neoplasm10.5GFAP, TP53
46diencephalic astrocytomas10.5GFAP, TP53
47breast fibroadenosis10.5GZMB, TIA1
48syringocystadenoma papilliferum10.5CRTC1, MAML2
49multicentric reticulohistiocytosis10.5CD5, KRT7
50benign angiitis of the central nervous system10.4CD5, TP53

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to necrotizing sialometaplasia

Symptoms for Necrotizing Sialometaplasia

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Drugs & Therapeutics for Necrotizing Sialometaplasia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Necrotizing Sialometaplasia


Cochrane evidence based reviews: sialometaplasia, necrotizing

Genetic Tests for Necrotizing Sialometaplasia

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Anatomical Context for Necrotizing Sialometaplasia

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MalaCards organs/tissues related to Necrotizing Sialometaplasia:

34
Salivary gland, T cells, Trachea, Tongue, Testes, Breast

Animal Models for Necrotizing Sialometaplasia or affiliated genes

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MGI Mouse Phenotypes related to Necrotizing Sialometaplasia:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2ACTC1, CDKN2A, GFAP, KIT, TP53, TP63
2MP:00030128.1CD5, CDKN2A, KIT, KRT5, TP53, TP63
3MP:00053818.0CDKN2A, GFAP, KIT, KRT5, TP53, TP63
4MP:00028737.7ACTC1, CD5, GFAP, KIT, MKI67, TP53
5MP:00053787.0ACTC1, CDKN2A, CRTC1, GFAP, KIT, KRT5

Publications for Necrotizing Sialometaplasia

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Articles related to Necrotizing Sialometaplasia:

(show top 50)    (show all 160)
idTitleAuthorsYear
1
Contralateral recurrence of necrotizing sialometaplasia of the hard palate after five months: a case report. (26734562)
2015
2
Spontaneous necrotizing sialometaplasia of the submandibular salivary gland in a Beagle dog. (26441480)
2015
3
Review of the literature on necrotizing sialometaplasia and case presentation. (25191669)
2015
4
Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature. (24634907)
2014
5
Necrotizing sialometaplasia: a diagnostic dilemma. (25284537)
2014
6
Necrotizing sialometaplasia: A rare lesion that mimics oral cancer clinically and histopathologically. (24837912)
2014
7
Imaging findings of necrotizing sialometaplasia of the parotid gland: case report and literature review. (24850145)
2014
8
Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus. (24863247)
2014
9
Necrotizing sialometaplasia of the palatal mucosa in patient with history of anorexia: review and case report. (24667056)
2014
10
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. (24353777)
2013
11
Necrotizing sialometaplasia in an HIV positive cocaine user: a case report. (24217688)
2013
12
Necrotizing sialometaplasia in a patient with an eating disorder: palatal ulcer accompanied by dental erosion due to binge-purging. (23375898)
2013
13
HIF-1I+, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. (23837804)
2013
14
The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. (22921832)
2012
15
Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. (20403036)
2010
16
Necrotizing sialometaplasia of the parotid gland in a dog. (21088187)
2010
17
Necrotizing sialometaplasia: a practical approach to the diagnosis. (19415943)
2009
18
Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. (19482450)
2009
19
Case of the month. Necrotizing sialometaplasia. (18567189)
2008
20
Necrotizing sialometaplasia: an important diagnosis--review of the literature and spectrum of clinical presentation. (15789986)
2005
21
Necrotizing sialometaplasia: a case report. (15503360)
2004
22
A case of necrotizing sialometaplasia in the upper lip. (12970596)
2003
23
Necrotizing sialometaplasia: a potential diagnostic pitfall. (11952867)
2002
24
Necrotizing sialometaplasia: report of a case after lower lip mucocele excision. (11117693)
2000
25
Necrotizing sialometaplasia: literature review and case reports. (8754467)
1996
26
Necrotizing sialometaplasia. (8084644)
1994
27
Necrotizing sialometaplasia (adenometaplasia) of the trachea. (8495967)
1993
28
Necrotizing sialometaplasia. (1543340)
1992
29
Necrotizing sialometaplasia. A clinicopathologic study of sixty-nine cases and review of the literature. (1923419)
1991
30
Necrotizing sialometaplasia: report of 12 new cases. (2248941)
1990
31
Necrotizing sialometaplasia. (3345688)
1988
32
Necrotizing sialometaplasia obscuring an underlying malignancy: report of a case. (3459842)
1986
33
Necrotizing sialometaplasia of palatal minor salivary glands: a report on 2 cases. (3855981)
1985
34
Case of the month. Necrotizing sialometaplasia. (6592257)
1984
35
Necrotizing sialometaplasia: frequency of histologic misdiagnosis. (6582439)
1984
36
Necrotizing sialometaplasia. (6829370)
1983
37
Necrotizing sialometaplasia: an early, nonulcerative presentation. (6952149)
1982
38
Necrotizing sialometaplasia of the nasal cavity. (7158708)
1982
39
Necrotizing sialometaplasia. (7242209)
1981
40
Necrotizing sialometaplasia in the setting of acute and chronic sinusitis. (7346696)
1981
41
Necrotizing sialometaplasia. (6951608)
1980
42
Necrotizing sialometaplasia: review of the literature and report of nonulcerative case. (286778)
1979
43
Necrotizing sialometaplasia: a result of ischemia? Report of two cases and review of the literature. (298661)
1979
44
Case for diagnosis. Necrotizing sialometaplasia, left hard palate. (113695)
1979
45
Necrotizing sialometaplasia involving the nasal cavity. (839936)
1977
46
Necrotizing sialometaplasia of the palate. Ulcerative or necrotizing stage of leukokeratosis nicotina palati? (826493)
1976
47
Necrotizing sialometaplasia. (1065844)
1976
48
Necrotizing sialometaplasia. Report of a case. (1164230)
1975
49
Necrotizing sialometaplasia. Report of five additional cases. (4524380)
1974
50
Necrotizing sialometaplasia. A disease simulating malignancy. (4716764)
1973

Variations for Necrotizing Sialometaplasia

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Expression for genes affiliated with Necrotizing Sialometaplasia

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Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for genes affiliated with Necrotizing Sialometaplasia

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GO Terms for genes affiliated with Necrotizing Sialometaplasia

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Cellular components related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.5GFAP, KRT5, KRT7
2cytoplasmGO:00057375.5ACTC1, CDKN2A, CRTC1, GFAP, GZMB, KIT

Biological processes related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.2TP53, TP63
2mitotic G1 DNA damage checkpointGO:003157110.1TP53, TP63
3response to X-rayGO:001016510.0TP53, TP63
4positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:19007409.8GZMB, TP53, TP63
5replicative senescenceGO:00903999.6CDKN2A, TP53
6entrainment of circadian clock by photoperiodGO:00431539.4CRTC1, TP53

Sources for Necrotizing Sialometaplasia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet