MCID: NCR003
MIFTS: 36

Necrotizing Sialometaplasia

Categories: Oral diseases

Aliases & Classifications for Necrotizing Sialometaplasia

MalaCards integrated aliases for Necrotizing Sialometaplasia:

Name: Necrotizing Sialometaplasia 12 14
Sialometaplasia, Necrotizing 41 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12901
ICD10 32 K11.8
MeSH 41 D012797
SNOMED-CT 64 109769000
UMLS 69 C0037033

Summaries for Necrotizing Sialometaplasia

MalaCards based summary : Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to adenosquamous carcinoma and squamous cell carcinoma. An important gene associated with Necrotizing Sialometaplasia is KRT5 (Keratin 5), and among its related pathways/superpathways are DNA Damage and Activation of BH3-only proteins. Affiliated tissues include salivary gland, t cells and trachea, and related phenotypes are digestive/alimentary and no phenotypic analysis

Wikipedia : 72 Necrotizing sialometaplasia (NS) is a benign, ulcerative lesion, usually located towards the back of the... more...

Related Diseases for Necrotizing Sialometaplasia

Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 adenosquamous carcinoma 30.2 KRT5 KRT7 TP53 TP63
2 squamous cell carcinoma 29.6 CDKN2A KRT7 MKI67 TP53 TP63
3 warthin tumor 29.4 CRTC1 KIT KRT7 MAML2
4 balloon cell malignant melanoma 10.6 KRT5 KRT7
5 benign breast adenomyoepithelioma 10.6 KRT5 KRT7
6 sensory organ benign neoplasm 10.6 KRT5 KRT7
7 middle ear adenoma 10.6 KRT5 KRT7
8 bile duct mucoepidermoid carcinoma 10.6 KRT5 KRT7
9 cystic basal cell carcinoma 10.6 KRT7 TP63
10 prostate squamous cell carcinoma 10.6 KRT5 KRT7
11 large cell acanthoma 10.6 KRT5 KRT7
12 vulvar intraepithelial neoplasia 10.6 KRT7 TP53
13 papillary adenoma 10.6 KRT5 KRT7
14 female reproductive endometrioid cancer 10.6 KRT7 TP53
15 apocrine sweat gland neoplasm 10.6 KRT5 KRT7
16 eccrine sweat gland neoplasm 10.6 KRT7 TP53
17 apocrine adenocarcinoma 10.6 KRT5 KRT7
18 brain ependymoma 10.5 MKI67 TP53
19 malignant giant cell tumor 10.5 ACTC1 TP53
20 breast adenomyoepithelioma 10.5 KRT5 KRT7
21 benign metastasizing leiomyoma 10.5 ACTC1 KRT7
22 breast myoepithelial neoplasm 10.5 KRT5 KRT7
23 bladder adenocarcinoma 10.5 KRT7 MKI67
24 papillary serous adenocarcinoma 10.5 KRT7 TP53
25 bowen's disease 10.5 KRT7 MKI67
26 frontal convexity meningioma 10.4 GFAP TP53
27 malignant spiradenoma 10.4 KRT5 KRT7 TP53
28 gliofibroma 10.4 GFAP TP53
29 cerebral convexity meningioma 10.4 GFAP TP53
30 protoplasmic astrocytoma 10.4 GFAP TP53
31 sweat gland cancer 10.4 KRT5 KRT7 TP53
32 cellular ependymoma 10.4 GFAP TP53
33 anaplastic ganglioglioma 10.4 ACTC1 GFAP
34 large cell carcinoma 10.4 KRT5 KRT7 TP63
35 central nervous system primitive neuroectodermal neoplasm 10.4 GFAP TP53
36 cutaneous leiomyosarcoma 10.4 ACTC1 GFAP
37 orbit lymphoma 10.4 GZMB TIA1
38 spiradenoma 10.4 ACTC1 KRT7 TP53
39 lichen sclerosus et atrophicus 10.4 GZMB TIA1
40 lymphomatoid granulomatosis 10.4 GZMB TIA1
41 granulosa cell tumor of the ovary 10.4 ACTC1 KRT7 TP53
42 cerebral neuroblastoma 10.4 GFAP TP53
43 mixed glioma 10.4 GFAP TP53
44 spinal cancer 10.4 GFAP TP53
45 viral esophagitis 10.4 GZMB TIA1
46 subcutaneous panniculitis-like t-cell lymphoma 10.4 GZMB TIA1
47 chordoid glioma 10.4 GFAP TP53
48 lymphocytic gastritis 10.4 GZMB TIA1
49 ependymoblastoma 10.4 GFAP TP53
50 syringocystadenoma papilliferum 10.4 ACTC1 GFAP

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to Necrotizing Sialometaplasia

Symptoms & Phenotypes for Necrotizing Sialometaplasia

MGI Mouse Phenotypes related to Necrotizing Sialometaplasia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.63 CDKN2A GFAP KIT KRT5 TP53 TP63
2 no phenotypic analysis MP:0003012 9.5 CD5 CDKN2A KIT KRT5 MKI67 TP53
3 normal MP:0002873 9.17 TP53 TP63 ACTC1 CD5 GFAP KIT

Drugs & Therapeutics for Necrotizing Sialometaplasia

Search Clinical Trials , NIH Clinical Center for Necrotizing Sialometaplasia

Cochrane evidence based reviews: sialometaplasia, necrotizing

Genetic Tests for Necrotizing Sialometaplasia

Anatomical Context for Necrotizing Sialometaplasia

MalaCards organs/tissues related to Necrotizing Sialometaplasia:

38
Salivary Gland, T Cells, Trachea, Tongue, Testes, Breast

Publications for Necrotizing Sialometaplasia

Articles related to Necrotizing Sialometaplasia:

(show top 50) (show all 162)
# Title Authors Year
1
Necrotizing sialometaplasia of the parotid gland associated with facial nerve paralysis. ( 28330578 )
2017
2
Necrotizing Sialometaplasia of the Hard Palate in a Patient Treated with Topical Nonsteroidal Anti-Inflammatory Drug. ( 27833767 )
2016
3
Necrotizing sialometaplasia of the lacrimal sac mimicking squamous cell carcinoma: Necrotizing dacyocystometaplasia. ( 26634609 )
2016
4
Necrotizing sialometaplasia: Manifestation of a localized unclassified vasculitis. ( 27166051 )
2016
5
Necrotizing Sialometaplasia of the Hard Palate: A Rare Entity of Dilemma on Cytology, Confirmatory on Histopathology. ( 26816899 )
2015
6
Contralateral recurrence of necrotizing sialometaplasia of the hard palate after five months: a case report. ( 26734562 )
2015
7
Parotid necrotizing sialometaplasia vs infarcted Warthin tumour. ( 25564889 )
2015
8
Surgical management of necrotizing sialometaplasia of palate. ( 26672431 )
2015
9
Necrotizing sialometaplasia related to vomiting and silastic ring vertical gastroplasty. ( 26504909 )
2015
10
Spontaneous necrotizing sialometaplasia of the submandibular salivary gland in a Beagle dog. ( 26441480 )
2015
11
Review of the literature on necrotizing sialometaplasia and case presentation. ( 25191669 )
2015
12
Necrotizing sialometaplasia: A diagnostic dilemma! ( 25948999 )
2014
13
Early references to necrotizing sialometaplasia. ( 24439923 )
2014
14
Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus. ( 24863247 )
2014
15
Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature. ( 24634907 )
2014
16
Necrotizing sialometaplasia: A rare lesion that mimics oral cancer clinically and histopathologically. ( 24837912 )
2014
17
Imaging findings of necrotizing sialometaplasia of the parotid gland: case report and literature review. ( 24850145 )
2014
18
Two rare entities in the same palate lesion: hyalinizing-type clear cell carcinoma and necrotizing sialometaplasia. ( 24820724 )
2014
19
Necrotizing sialometaplasia of the nasopharynx with parapharyngeal extension: Case report and brief review of the literature. ( 25531850 )
2014
20
Necrotizing sialometaplasia of the palatal mucosa in patient with history of anorexia: review and case report. ( 24667056 )
2014
21
Necrotizing sialometaplasia: a diagnostic dilemma. ( 25284537 )
2014
22
HIF-1I+, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. ( 23837804 )
2013
23
A case of necrotizing sialometaplasia involving bilateral parotid glands. ( 23159016 )
2013
24
Oral and maxillofacial pathology. Case of the month. Diagnosis: Necrotizing sialometaplasia. ( 23930450 )
2013
25
Necrotizing sialometaplasia in a patient with an eating disorder: palatal ulcer accompanied by dental erosion due to binge-purging. ( 23375898 )
2013
26
Necrotizing sialometaplasia in an HIV positive cocaine user: a case report. ( 24217688 )
2013
27
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. ( 24353777 )
2013
28
Mandibular fracture and necrotizing sialometaplasia in a rabbit. ( 23561940 )
2013
29
CT findings of necrotizing sialometaplasia. ( 22074871 )
2012
30
The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. ( 22921832 )
2012
31
Significance of Ki-67 and p53 immunoexpression in the differential diagnosis of oral necrotizing sialometaplasia and squamous cell carcinoma. ( 22197541 )
2012
32
Necrotizing sialometaplasia within a benign mixed tumor of parotid gland. ( 22200659 )
2012
33
Necrotizing sialometaplasia of palate: a case report. ( 22957289 )
2012
34
Necrotizing sialometaplasia as a cause of a non-ulcerated nodule in the hard palate: a case report. ( 21861916 )
2011
35
Case report of necrotizing sialometaplasia. ( 21217621 )
2011
36
Necrotizing sialometaplasia of palate: a case report. ( 21977472 )
2011
37
Necrotizing sialometaplasia in a patient who is HIV positive: a case report. ( 20618783 )
2010
38
Necrotizing sialometaplasia of bronchial mucosa. ( 19948640 )
2010
39
Necrotizing sialometaplasia-a practical approach to the diagnosis. ( 20073597 )
2010
40
Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. ( 20403036 )
2010
41
Necrotizing sialometaplasia of the parotid gland in a dog. ( 21088187 )
2010
42
A clinical case of necrotizing sialometaplasia and conjunctival hemorrhage. ( 20842082 )
2010
43
Necrotizing sialometaplasia of tongue. ( 21886996 )
2009
44
Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. ( 19482450 )
2009
45
Necrotizing sialometaplasia accompanied by adenoid cystic carcinoma on the soft palate. ( 19434292 )
2009
46
Necrotizing sialometaplasia: a practical approach to the diagnosis. ( 19415943 )
2009
47
Bilateral localization of necrotizing sialometaplasia: a case report. ( 20184708 )
2009
48
Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma. ( 19118785 )
2009
49
Case of the month. Necrotizing sialometaplasia. ( 18567189 )
2008
50
Case report. MRI findings of necrotizing sialometaplasia. ( 18487385 )
2008

Variations for Necrotizing Sialometaplasia

Expression for Necrotizing Sialometaplasia

Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for Necrotizing Sialometaplasia

GO Terms for Necrotizing Sialometaplasia

Cellular components related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.32 ACTC1 CDKN2A CRTC1 GFAP GZMB KRT5

Biological processes related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.78 ACTC1 CDKN2A KIT TP53
2 cell proliferation GO:0008283 9.73 CD5 MKI67 TP53 TP63
3 entrainment of circadian clock by photoperiod GO:0043153 9.46 CRTC1 TP53
4 apoptotic process GO:0006915 9.43 ACTC1 CDKN2A GZMB TIA1 TP53 TP63
5 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.4 TP53 TP63
6 replicative senescence GO:0090399 9.37 CDKN2A TP53
7 protein homotetramerization GO:0051289 9.33 CRTC1 TP53 TP63
8 mitotic G1 DNA damage checkpoint GO:0031571 9.32 TP53 TP63
9 somatic stem cell division GO:0048103 9.26 CDKN2A KIT
10 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 8.8 GZMB TP53 TP63

Molecular functions related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MDM2/MDM4 family protein binding GO:0097371 8.62 TP53 TP63

Sources for Necrotizing Sialometaplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
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41 MeSH
42 MESH via Orphanet
43 MGI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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