MCID: NCR003
MIFTS: 34

Necrotizing Sialometaplasia malady

Category: Oral diseases

Aliases & Classifications for Necrotizing Sialometaplasia

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Aliases & Descriptions for Necrotizing Sialometaplasia:

Name: Necrotizing Sialometaplasia 11 13
 
Sialometaplasia, Necrotizing 39 68

Classifications:



External Ids:

Disease Ontology11 DOID:12901
ICD1030 K11.8
SNOMED-CT62 109769000
MeSH39 D012797

Summaries for Necrotizing Sialometaplasia

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Wikipedia:71 Necrotizing sialometaplasia (NS) is a benign, ulcerative lesion, usually located towards the back of the... more...

MalaCards based summary: Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to wolffian adnexal neoplasm and skin amelanotic melanoma. An important gene associated with Necrotizing Sialometaplasia is KRT5 (Keratin 5), and among its related pathways are Activation of BH3-only proteins and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include salivary gland, t cells and trachea, and related mouse phenotypes are digestive/alimentary and no phenotypic analysis.

Related Diseases for Necrotizing Sialometaplasia

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Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 136)
idRelated DiseaseScoreTop Affiliating Genes
1wolffian adnexal neoplasm10.3MKI67, TP53
2skin amelanotic melanoma10.3KRT5, KRT7
3radiculopathy10.3KRT7, TP63
4liver fibrosarcoma10.3GFAP, TP53
5cervical adenoid cystic carcinoma10.3GFAP, TP53
6mucinous cystadenocarcinoma10.3ACTC1, MKI67
7sclerosing breast papilloma10.2KRT5, KRT7, TP53
8angiofollicular lymph hyperplasia10.2ACTC1, GFAP
9benign ependymoma10.2KRT5, TP53, TP63
10cellular ependymoma10.2KRT5, KRT7, TP53
11scirrhous adenocarcinoma10.2ACTC1, KRT5, TP63
12bronchitis10.2GFAP, TP53
13bile duct clear cell adenocarcinoma10.2GFAP, TP53
14growth retardation hydrocephaly lung hypoplasia10.2ACTC1, KRT7, TP53
15small intestine leiomyoma10.2KRT5, TP53
16vagina leiomyosarcoma10.2ACTC1, GFAP
17malignant glioma10.2GZMB, TIA1
18alström syndrome10.2GZMB, TIA1
19childhood mediastinal neurogenic tumor10.2CRTC1, MAML2
20malignant spindle cell melanoma10.2GZMB, MKI67, TP53
21spleen angiosarcoma10.2ACTC1, GFAP
22carbon monoxide-induced parkinsonism10.2ACTC1, KIT
23laryngeal mucoepidermoid carcinoma10.2KRT5, KRT7
24spinal cord intramedullary teratoma10.2CD5, KRT5, TP53
25optic papillitis10.2CD5, TIA1
26skeletal muscle cancer10.2GZMB, TIA1
27linear lichen planus10.2GZMB, TIA1, TP53
28cervical benign neoplasm10.2GFAP, TP53
29childhood medulloblastoma10.2GFAP, TP53, TP63
30cauda equina intradural extramedullary astrocytoma10.2ACTC1, GFAP, TP63
31tibial adamantinoma10.1GZMB, TIA1
32conjunctival intraepithelial neoplasm10.1CRTC1, MAML2
33heavy chain disease10.1GFAP, KRT5, MAML2
34ebola hemorrhagic fever10.1KRT5, KRT7
35superior limbic keratoconjunctivitis10.1GZMB, TIA1
36multidrug-resistant tuberculosis10.1CRTC1, KRT5, MAML2
37malignant teratoma10.1GZMB, KRT7, TIA1
38choriocarcinoma of ovary10.1KIT, KRT5, TP53
39myotonic disease10.1CD5, KRT5, KRT7
40atypical lipomatous tumor10.1KIT, TP63
41clear cell adenofibroma10.1CDKN2A, TP53
42collagen type iii glomerulopathy10.1GZMB, TIA1
43lacrimal gland adenoid cystic carcinoma10.1CDKN2A, TP53
44juvenile astrocytoma10.1ACTC1, GFAP, TP53
45enchondromatosis dwarfism deafness10.1KIT, MKI67, TP53
46deep angioma10.1CRTC1, KRT7, MAML2
47prostate lymphoma10.1KRT5, KRT7
48pustulosis palmaris et plantaris10.1ACTC1, KIT, MKI67
49middle ear adenocarcinoma10.1KIT, KRT5, KRT7
50leiomyomatosis10.1GFAP, KIT

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to necrotizing sialometaplasia

Symptoms & Phenotypes for Necrotizing Sialometaplasia

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MGI Mouse Phenotypes related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5CDKN2A, GFAP, KIT, KRT5, TP53, TP63
2MP:00030128.5CD5, CDKN2A, KIT, KRT5, TP53, TP63
3MP:00028737.8ACTC1, CD5, GFAP, KIT, MKI67, TP53

Drugs & Therapeutics for Necrotizing Sialometaplasia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Necrotizing Sialometaplasia


Cochrane evidence based reviews: sialometaplasia, necrotizing

Genetic Tests for Necrotizing Sialometaplasia

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Anatomical Context for Necrotizing Sialometaplasia

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MalaCards organs/tissues related to Necrotizing Sialometaplasia:

36
Salivary gland, T cells, Trachea, Tongue, Testes, Breast

Publications for Necrotizing Sialometaplasia

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Articles related to Necrotizing Sialometaplasia:

(show top 50)    (show all 161)
idTitleAuthorsYear
1
Necrotizing sialometaplasia: Manifestation of a localized unclassified vasculitis. (27166051)
2016
2
Necrotizing Sialometaplasia of the Hard Palate in a Patient Treated with Topical Nonsteroidal Anti-Inflammatory Drug. (27833767)
2016
3
Necrotizing sialometaplasia of the lacrimal sac mimicking squamous cell carcinoma: Necrotizing dacyocystometaplasia. (26634609)
2016
4
Necrotizing sialometaplasia related to vomiting and silastic ring vertical gastroplasty. (26504909)
2015
5
Contralateral recurrence of necrotizing sialometaplasia of the hard palate after five months: a case report. (26734562)
2015
6
Review of the literature on necrotizing sialometaplasia and case presentation. (25191669)
2015
7
Surgical management of necrotizing sialometaplasia of palate. (26672431)
2015
8
Necrotizing Sialometaplasia of the Hard Palate: A Rare Entity of Dilemma on Cytology, Confirmatory on Histopathology. (26816899)
2015
9
Spontaneous necrotizing sialometaplasia of the submandibular salivary gland in a Beagle dog. (26441480)
2015
10
Parotid necrotizing sialometaplasia vs infarcted Warthin tumour. (25564889)
2015
11
Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature. (24634907)
2014
12
Necrotizing sialometaplasia of the palatal mucosa in patient with history of anorexia: review and case report. (24667056)
2014
13
Two rare entities in the same palate lesion: hyalinizing-type clear cell carcinoma and necrotizing sialometaplasia. (24820724)
2014
14
Necrotizing sialometaplasia of the nasopharynx with parapharyngeal extension: Case report and brief review of the literature. (25531850)
2014
15
Early references to necrotizing sialometaplasia. (24439923)
2014
16
Imaging findings of necrotizing sialometaplasia of the parotid gland: case report and literature review. (24850145)
2014
17
Necrotizing sialometaplasia: a diagnostic dilemma. (25284537)
2014
18
Necrotizing sialometaplasia: A diagnostic dilemma! (25948999)
2014
19
Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus. (24863247)
2014
20
Necrotizing sialometaplasia: A rare lesion that mimics oral cancer clinically and histopathologically. (24837912)
2014
21
Oral and maxillofacial pathology. Case of the month. Diagnosis: Necrotizing sialometaplasia. (23930450)
2013
22
Mandibular fracture and necrotizing sialometaplasia in a rabbit. (23561940)
2013
23
Necrotizing sialometaplasia in a patient with an eating disorder: palatal ulcer accompanied by dental erosion due to binge-purging. (23375898)
2013
24
A case of necrotizing sialometaplasia involving bilateral parotid glands. (23159016)
2013
25
HIF-1I+, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. (23837804)
2013
26
Necrotizing sialometaplasia in an HIV positive cocaine user: a case report. (24217688)
2013
27
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. (24353777)
2013
28
CT findings of necrotizing sialometaplasia. (22074871)
2012
29
Significance of Ki-67 and p53 immunoexpression in the differential diagnosis of oral necrotizing sialometaplasia and squamous cell carcinoma. (22197541)
2012
30
Necrotizing sialometaplasia within a benign mixed tumor of parotid gland. (22200659)
2012
31
Necrotizing sialometaplasia of palate: a case report. (22957289)
2012
32
The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. (22921832)
2012
33
Necrotizing sialometaplasia of palate: a case report. (21977472)
2011
34
Case report of necrotizing sialometaplasia. (21217621)
2011
35
Necrotizing sialometaplasia as a cause of a non-ulcerated nodule in the hard palate: a case report. (21861916)
2011
36
Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. (20403036)
2010
37
Necrotizing sialometaplasia of the parotid gland in a dog. (21088187)
2010
38
A clinical case of necrotizing sialometaplasia and conjunctival hemorrhage. (20842082)
2010
39
Necrotizing sialometaplasia in a patient who is HIV positive: a case report. (20618783)
2010
40
Necrotizing sialometaplasia of bronchial mucosa. (19948640)
2010
41
Necrotizing sialometaplasia-a practical approach to the diagnosis. (20073597)
2010
42
Necrotizing sialometaplasia of tongue. (21886996)
2009
43
Necrotizing sialometaplasia: a practical approach to the diagnosis. (19415943)
2009
44
Necrotizing sialometaplasia accompanied by adenoid cystic carcinoma on the soft palate. (19434292)
2009
45
Bilateral localization of necrotizing sialometaplasia: a case report. (20184708)
2009
46
Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. (19482450)
2009
47
Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma. (19118785)
2009
48
Necrotizing sialometaplasia of the palate in a cocaine-using patient. A case report. (18427364)
2008
49
Case report. MRI findings of necrotizing sialometaplasia. (18487385)
2008
50
Case of the month. Necrotizing sialometaplasia. (18567189)
2008

Variations for Necrotizing Sialometaplasia

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Expression for genes affiliated with Necrotizing Sialometaplasia

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Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for genes affiliated with Necrotizing Sialometaplasia

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GO Terms for genes affiliated with Necrotizing Sialometaplasia

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Cellular components related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytosolGO:00058296.5ACTC1, CDKN2A, CRTC1, GFAP, GZMB, KRT5
2cytoplasmGO:00057376.4ACTC1, CDKN2A, CRTC1, GFAP, GZMB, KIT

Biological processes related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.5TP53, TP63
2mitotic G1 DNA damage checkpointGO:003157110.5TP53, TP63
3entrainment of circadian clock by photoperiodGO:004315310.3CRTC1, TP53
4response to X-rayGO:001016510.2TP53, TP63
5positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:190074010.1GZMB, TP53, TP63
6protein homotetramerizationGO:00512899.8CRTC1, TP53, TP63
7replicative senescenceGO:00903999.8CDKN2A, TP53
8somatic stem cell divisionGO:00481039.0CDKN2A, KIT
9apoptotic processGO:00069158.6ACTC1, CDKN2A, GZMB, TIA1, TP53, TP63

Sources for Necrotizing Sialometaplasia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet