MCID: NCR003
MIFTS: 32

Necrotizing Sialometaplasia malady

Summaries for Necrotizing Sialometaplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Necrotizing sialometaplasia (also spelled necrotising sialometaplasia) is a benign ulcerative lesion... more...

MalaCards: Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to squamous cell carcinoma and sickle cell anemia. An important gene associated with Necrotizing Sialometaplasia is TP53 (tumor protein p53), and among its related pathways is Notch signaling pathway. The compounds dutp and irinotecan have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, t cells and tongue.

Aliases & Classifications for Necrotizing Sialometaplasia

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

necrotizing sialometaplasia 8 10
sialometaplasia, necrotizing 60


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Disease Ontology8 DOID:12901
SNOMED-CT56 109769000
MeSH34 D012797

Related Diseases for Necrotizing Sialometaplasia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma10.4
2sickle cell anemia10.1
3tracheitis10.1
4maxillary sinus squamous cell carcinoma10.1
5sialadenitis10.1
6adenoid cystic carcinoma10.1
7adenosquamous carcinoma10.1
8adenoiditis10.1
9adenocarcinoma10.1
10eating disorder10.1
11esophagus adenocarcinoma10.1
12ischemia10.1
13lip cancer10.1
14actinic keratosis10.0TP53
15esophageal cancer10.0TP53
16benign meningioma10.0MKI67
17keratoacanthoma10.0MKI67
18smooth muscle tumor10.0MKI67
19ductal carcinoma in situ10.0TP53
20leukoplakia10.0MKI67
21cervical squamous cell carcinoma10.0MKI67
22leiomyosarcoma10.0TP53
23ependymoma10.0MKI67
24cervical intraepithelial neoplasia10.0MKI67
25gastrointestinal stromal tumor10.0MKI67
26kidney cancer10.0TP53
27bladder transitional cell carcinoma10.0TP53, MKI67
28breast cancer, invasive ductal10.0TP53, MKI67
29barrett's esophagus10.0MKI67, TP53
30adrenocortical carcinoma10.0MKI67, TP53
31leukemia10.0TP53
32bladder carcinoma10.0MKI67, TP53
33anaplastic astrocytoma10.0TP53, MKI67
34basal cell carcinoma10.0MKI67, TP53
35transitional cell carcinoma10.0MKI67, TP53
36lacrimal gland cancer10.0CRTC1, MAML2
37cutaneous mucoepidermoid carcinoma10.0MAML2, CRTC1
38lipoadenoma10.0MAML2, CRTC1
39cervical adenosquamous carcinoma10.0CRTC1, MAML2
40epithelial-myoepithelial carcinoma10.0MAML2, CRTC1
41hidradenoma10.0MAML2, CRTC1
42oligodendroglioma10.0TP53, MKI67
43b-cell lymphomas10.0MKI67, TP53
44mucoepidermoid carcinoma10.0MAML2, MKI67, CRTC1

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to necrotizing sialometaplasia

Clinical Features for Necrotizing Sialometaplasia

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Drugs & Therapeutics for Necrotizing Sialometaplasia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Necrotizing Sialometaplasia

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Anatomical Context for Necrotizing Sialometaplasia

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32MalaCards
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MalaCards organs/tissues related to Necrotizing Sialometaplasia:

32
Salivary gland, T cells, Tongue, Trachea, Breast, Testes

Animal Models for Necrotizing Sialometaplasia or affiliated genes

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Publications for Necrotizing Sialometaplasia

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50PubMed
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Articles related to Necrotizing Sialometaplasia:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. (24353777)
2013
2
Necrotizing sialometaplasia in an HIV positive cocaine user: a case report. (24217688)
2013
3
Necrotizing sialometaplasia within a benign mixed tumor of parotid gland. (22200659)
2012
4
Significance of Ki-67 and p53 immunoexpression in the differential diagnosis of oral necrotizing sialometaplasia and squamous cell carcinoma. (22197541)
2012
5
Necrotizing sialometaplasia as a cause of a non-ulcerated nodule in the hard palate: a case report. (21861916)
2011
6
Necrotizing sialometaplasia of palate: a case report. (21977472)
2011
7
Case report of necrotizing sialometaplasia. (21217621)
2011
8
A clinical case of necrotizing sialometaplasia and conjunctival hemorrhage. (20842082)
2010
9
Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. (19482450)
2009
10
Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma. (19118785)
2009
11
Case of the month. Necrotizing sialometaplasia. (18567189)
2008
12
Necrotizing sialometaplasia of the palate in a cocaine-using patient. A case report. (18427364)
2008
13
Bilateral presentation of necrotizing sialometaplasia--a case report. (18087930)
2007
14
Necrotizing sialometaplasia: report of five cases. (15292869)
2004
15
Oral pathology quiz #35. Case number 2. Necrotizing sialometaplasia. (16795953)
2002
16
Necrotizing sialometaplasia coincident with ipsilateral infarcted antral polyps. (8645669)
1996
17
Canine necrotizing sialometaplasia: a case report and review of the literature. (7820759)
1995
18
Necrotizing sialometaplasia of the larynx. A report of two cases and a review of the literature. (7741108)
1995
19
Necrotizing sialometaplasia (adenometaplasia) of the trachea. (8495967)
1993
20
Necrotizing sialometaplasia: a review and two case reports. (1521257)
1992
21
Necrotizing sialometaplasia. (1624902)
1992
22
Necrotizing sialometaplasia. A clinicopathologic study of sixty-nine cases and review of the literature. (1923419)
1991
23
Necrotizing sialometaplasia: report of two cases. (3473698)
1987
24
Necrotizing sialometaplasia obscuring an underlying malignancy: report of a case. (3459842)
1986
25
Necrotizing sialometaplasia: a sheep in wolf's clothing. Healing as a diagnostic test. (3947128)
1986
26
Necrotizing sialometaplasia: a case with metachronous lesions. (3465934)
1986
27
Necrotizing sialometaplasia: report of a case and review of the Japanese literature. (3869223)
1985
28
Recurrent necrotizing sialometaplasia of the nasal cavity. (3927243)
1985
29
Necrotizing sialometaplasia: a diagnostic dilemma. (6584633)
1984
30
Necrotizing sialometaplasia. (6829370)
1983
31
Necrotizing sialometaplasia: report of five cases. (6836063)
1983
32
Necrotizing sialometaplasia: an early, nonulcerative presentation. (6952149)
1982
33
Necrotizing sialometaplasia of the nasal cavity. (7158708)
1982
34
Necrotizing sialometaplasia. (7242209)
1981
35
Necrotizing sialometaplasia: literature review and presentation of five cases. (6944453)
1981
36
Necrotizing sialometaplasia--a lesion of minor salivary glands that mimics malignancies. (7337385)
1981
37
Necrotizing sialometaplasia--a clinical entity for dental awareness. (6765804)
1981
38
Necrotizing sialometaplasia: report of an ulcerative case. (6942043)
1981
39
Necrotizing sialometaplasia-a clinical enity for dental awareness. (6940266)
1981
40
Necrotizing sialometaplasia in a patient with Buerger's disease and Raynaud's phenomenon. (6928308)
1980
41
Necrotizing sialometaplasia of the cheek: report of case and review of literature. (6929908)
1980
42
Necrotizing sialometaplasia. (299075)
1979
43
Necrotizing sialometaplasia. (284281)
1979
44
NECROTIZING SIALOMETAPLASIA. (269338)
1977
45
A patient with necrotizing sialometaplasia. (412803)
1977
46
Necrotizing sialometaplasia of the mandible. (266152)
1977
47
Necrotizing sialometaplasia involving the mucous glands of the nasal cavity. (903148)
1977
48
Necrotizing sialometaplasia of the palate. (1066464)
1976
49
Necrotizing sialometaplasia: report of three cases. (1066463)
1976
50
Necrotizing sialometaplasia. Report of five additional cases. (4524380)
1974

Genetic Variations for Necrotizing Sialometaplasia

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Expression for genes affiliated with Necrotizing Sialometaplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Necrotizing Sialometaplasia

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Pathways for genes affiliated with Necrotizing Sialometaplasia

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4TP53, MAML2

Compounds for genes affiliated with Necrotizing Sialometaplasia

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dutp449.2TP53, MKI67
2irinotecan44 49 1111.2TP53, MKI67
3mitomycin c449.1TP53, MKI67
4cyclophosphamide44 49 1111.1TP53, MKI67
5vincristine44 49 1111.0MKI67, TP53
6thymidylate448.8TP53, MKI67

GO Terms for genes affiliated with Necrotizing Sialometaplasia

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16Gene Ontology
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Biological processes related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:0459448.8TP53, MAML2, CRTC1

Products for genes affiliated with Necrotizing Sialometaplasia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Necrotizing Sialometaplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet