MCID: NCR003
MIFTS: 34

Necrotizing Sialometaplasia malady

Category: Oral diseases

Aliases & Classifications for Necrotizing Sialometaplasia

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Aliases & Descriptions for Necrotizing Sialometaplasia:

Name: Necrotizing Sialometaplasia 11 13
 
Sialometaplasia, Necrotizing 38 67

Classifications:



External Ids:

Disease Ontology11 DOID:12901
ICD1029 K11.8
SNOMED-CT61 109769000
MeSH38 D012797

Summaries for Necrotizing Sialometaplasia

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Wikipedia:70 Necrotizing sialometaplasia (NS) is a benign, ulcerative lesion, usually located towards the back of the... more...

MalaCards based summary: Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to peptic ulcer disease and cryptosporidiosis. An important gene associated with Necrotizing Sialometaplasia is KRT5 (Keratin 5), and among its related pathways are Inhibition of Ribosome Biogenesis by p14(ARF) and Activation of BH3-only proteins. Affiliated tissues include salivary gland, trachea and tongue, and related mouse phenotypes are digestive/alimentary and muscle.

Related Diseases for Necrotizing Sialometaplasia

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Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1peptic ulcer disease10.7MKI67, TP53
2cryptosporidiosis10.7KRT5, TP53
3mushroom workers' lung10.7ACTC1, TP53
4signet ring basal cell carcinoma10.6KRT7, TP63
5lacrimal gland mucoepidermoid carcinoma10.6KRT5, KRT7
6placental site trophoblastic tumor10.6ACTC1, MKI67
7familial periodic paralysis10.6KRT5, KRT7
8epidermolytic acanthoma10.6KRT5, KRT7
9female breast lower-inner quadrant cancer10.6KRT5, KRT7
10breast neuroendocrine neoplasm10.6KRT5, KRT7
11eccrine papillary adenoma10.6ACTC1, TP53
12mollaret meningitis10.6ACTC1, KRT7
13skin meningioma10.6GFAP, TP53
14vulvar alveolar soft part sarcoma10.6ACTC1, TP63
15glomeruloid hemangioma10.6GFAP, TP53
16infiltrating lipoma10.5GFAP, TP53
17renal pelvis inverted papilloma10.5GFAP, TP53
18skin glomangioma10.5ACTC1, TP53
19brain glioma10.5GFAP, TP53
20vulvar benign neoplasm10.5GFAP, TP53
21hypersensitivity reaction type ii disease10.5GFAP, TP53
22brainstem intraparenchymal clear cell meningioma10.5GFAP, TP53
23anaplastic oligodendroglioma10.5ACTC1, GFAP
24yolk sac tumor of central nervous system10.5GFAP, TP53
25tamoxifen-related endometrial lesion10.5KRT5, KRT7, TP53
26atypical choroid plexus papilloma10.5GFAP, TP53
27external ear disease10.5GFAP, TP53
28ganglioglioma10.5GFAP, TP53
29chondroblastoma10.5ACTC1, GFAP
30male infertility10.5GZMB, TIA1
31mast-cell sarcoma10.5KRT5, KRT7
32eosinophilia10.5GZMB, TIA1
33pulmonary venoocclusive disease10.5ACTC1, GFAP
34subependymal nodular heterotopia10.5GZMB, TIA1
35pseudotyphus of california10.5GZMB, TIA1
36granulomatous gastritis10.5GZMB, TIA1
37clivus chordoma10.5GZMB, TIA1
38plexopathy10.4GFAP, TP53
39diffuse large b-cell lymphoma with chronic inflammation10.4GZMB, TIA1
40polycystic ovary syndrome10.4GZMB, TIA1
41paranasal sinus cancer, adult10.4ACTC1, KRT7, TP53
42mucoepidermoid thyroid carcinoma10.4CRTC1, MAML2
43xq12-q13.3 duplication syndrome10.4ACTC1, KIT
44malignant pineal area germ cell neoplasm10.4GFAP, TP53
45breast fibroadenosis10.4GZMB, TIA1
46syringocystadenoma papilliferum10.4CRTC1, MAML2
47diencephalic astrocytomas10.4GFAP, TP53
48multicentric reticulohistiocytosis10.4CD5, KRT7
49benign angiitis of the central nervous system10.4CD5, TP53
50adult choroid plexus cancer10.4GFAP, TP53

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to necrotizing sialometaplasia

Symptoms for Necrotizing Sialometaplasia

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Drugs & Therapeutics for Necrotizing Sialometaplasia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Necrotizing Sialometaplasia


Cochrane evidence based reviews: sialometaplasia, necrotizing

Genetic Tests for Necrotizing Sialometaplasia

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Anatomical Context for Necrotizing Sialometaplasia

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MalaCards organs/tissues related to Necrotizing Sialometaplasia:

35
Salivary gland, Trachea, Tongue, T cells, Testes

Animal Models for Necrotizing Sialometaplasia or affiliated genes

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MGI Mouse Phenotypes related to Necrotizing Sialometaplasia:

40
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.0CDKN2A, GFAP, KIT, KRT5, TP53, TP63
2MP:00053698.9ACTC1, CDKN2A, GFAP, KIT, TP53, TP63
3MP:00030128.8CD5, CDKN2A, KIT, KRT5, TP53, TP63
4MP:00028738.0ACTC1, CD5, GFAP, KIT, MKI67, TP53
5MP:00053787.8ACTC1, CDKN2A, CRTC1, GFAP, KIT, KRT5

Publications for Necrotizing Sialometaplasia

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Articles related to Necrotizing Sialometaplasia:

(show top 50)    (show all 161)
idTitleAuthorsYear
1
Contralateral recurrence of necrotizing sialometaplasia of the hard palate after five months: a case report. (26734562)
2015
2
Spontaneous necrotizing sialometaplasia of the submandibular salivary gland in a Beagle dog. (26441480)
2015
3
Review of the literature on necrotizing sialometaplasia and case presentation. (25191669)
2015
4
Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature. (24634907)
2014
5
Necrotizing sialometaplasia: a diagnostic dilemma. (25284537)
2014
6
Necrotizing sialometaplasia: A rare lesion that mimics oral cancer clinically and histopathologically. (24837912)
2014
7
Imaging findings of necrotizing sialometaplasia of the parotid gland: case report and literature review. (24850145)
2014
8
Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus. (24863247)
2014
9
Necrotizing sialometaplasia of the palatal mucosa in patient with history of anorexia: review and case report. (24667056)
2014
10
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. (24353777)
2013
11
Necrotizing sialometaplasia in an HIV positive cocaine user: a case report. (24217688)
2013
12
Necrotizing sialometaplasia in a patient with an eating disorder: palatal ulcer accompanied by dental erosion due to binge-purging. (23375898)
2013
13
HIF-1I+, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. (23837804)
2013
14
The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. (22921832)
2012
15
Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. (20403036)
2010
16
Necrotizing sialometaplasia of the parotid gland in a dog. (21088187)
2010
17
Necrotizing sialometaplasia: a practical approach to the diagnosis. (19415943)
2009
18
Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. (19482450)
2009
19
Case of the month. Necrotizing sialometaplasia. (18567189)
2008
20
Necrotizing sialometaplasia: an important diagnosis--review of the literature and spectrum of clinical presentation. (15789986)
2005
21
Necrotizing sialometaplasia: a case report. (15503360)
2004
22
A case of necrotizing sialometaplasia in the upper lip. (12970596)
2003
23
Necrotizing sialometaplasia: a potential diagnostic pitfall. (11952867)
2002
24
Necrotizing sialometaplasia: report of a case after lower lip mucocele excision. (11117693)
2000
25
Necrotizing sialometaplasia: literature review and case reports. (8754467)
1996
26
Necrotizing sialometaplasia. (8084644)
1994
27
Necrotizing sialometaplasia (adenometaplasia) of the trachea. (8495967)
1993
28
Necrotizing sialometaplasia. (1543340)
1992
29
Necrotizing sialometaplasia. A clinicopathologic study of sixty-nine cases and review of the literature. (1923419)
1991
30
Necrotizing sialometaplasia: report of 12 new cases. (2248941)
1990
31
Necrotizing sialometaplasia. (3345688)
1988
32
Necrotizing sialometaplasia obscuring an underlying malignancy: report of a case. (3459842)
1986
33
Necrotizing sialometaplasia of palatal minor salivary glands: a report on 2 cases. (3855981)
1985
34
Case of the month. Necrotizing sialometaplasia. (6592257)
1984
35
Necrotizing sialometaplasia: frequency of histologic misdiagnosis. (6582439)
1984
36
Necrotizing sialometaplasia. (6829370)
1983
37
Necrotizing sialometaplasia: an early, nonulcerative presentation. (6952149)
1982
38
Necrotizing sialometaplasia of the nasal cavity. (7158708)
1982
39
Necrotizing sialometaplasia. (7242209)
1981
40
Necrotizing sialometaplasia in the setting of acute and chronic sinusitis. (7346696)
1981
41
Necrotizing sialometaplasia. (6951608)
1980
42
Necrotizing sialometaplasia: review of the literature and report of nonulcerative case. (286778)
1979
43
Necrotizing sialometaplasia: a result of ischemia? Report of two cases and review of the literature. (298661)
1979
44
Case for diagnosis. Necrotizing sialometaplasia, left hard palate. (113695)
1979
45
Necrotizing sialometaplasia involving the nasal cavity. (839936)
1977
46
Necrotizing sialometaplasia of the palate. Ulcerative or necrotizing stage of leukokeratosis nicotina palati? (826493)
1976
47
Necrotizing sialometaplasia. (1065844)
1976
48
Necrotizing sialometaplasia. Report of a case. (1164230)
1975
49
Necrotizing sialometaplasia. Report of five additional cases. (4524380)
1974
50
Necrotizing sialometaplasia. A disease simulating malignancy. (4716764)
1973

Variations for Necrotizing Sialometaplasia

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Expression for genes affiliated with Necrotizing Sialometaplasia

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Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for genes affiliated with Necrotizing Sialometaplasia

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GO Terms for genes affiliated with Necrotizing Sialometaplasia

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Cellular components related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.5GFAP, KRT5, KRT7
2cytoplasmGO:00057375.5ACTC1, CDKN2A, CRTC1, GFAP, GZMB, KIT

Biological processes related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1response to X-rayGO:001016510.2TP53, TP63
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.1TP53, TP63
3mitotic G1 DNA damage checkpointGO:003157110.0TP53, TP63
4positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:19007409.8GZMB, TP53, TP63
5replicative senescenceGO:00903999.6CDKN2A, TP53
6entrainment of circadian clock by photoperiodGO:00431539.4CRTC1, TP53

Sources for Necrotizing Sialometaplasia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet