MCID: NCR003
MIFTS: 36

Necrotizing Sialometaplasia malady

Oral diseases category
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Summaries for Necrotizing Sialometaplasia

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Necrotizing sialometaplasia (also spelled necrotising sialometaplasia) is a benign ulcerative lesion... more...

MalaCards: Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to sickle cell anemia and tracheitis. An important gene associated with Necrotizing Sialometaplasia is MKI67 (marker of proliferation Ki-67), and among its related pathways are Cell Cycle / Checkpoint Control and Pre-NOTCH Expression and Processing. The compounds dutp and irinotecan have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, tongue and t cells.

Aliases & Classifications for Necrotizing Sialometaplasia

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8Disease Ontology, 10DISEASES, 62UMLS, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


Aliases & Descriptions:

necrotizing sialometaplasia 8 10
sialometaplasia, necrotizing 62


External Ids:

Disease Ontology8 DOID:12901
SNOMED-CT58 109769000
MeSH35 D012797

Related Diseases for Necrotizing Sialometaplasia

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to necrotizing sialometaplasia

Symptoms for Necrotizing Sialometaplasia

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Drugs & Therapeutics for Necrotizing Sialometaplasia

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Necrotizing Sialometaplasia

Search NIH Clinical Center for Necrotizing Sialometaplasia

Genetic Tests for Necrotizing Sialometaplasia

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Anatomical Context for Necrotizing Sialometaplasia

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33MalaCards
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MalaCards organs/tissues related to Necrotizing Sialometaplasia:

33
Salivary gland, Tongue, T cells, Trachea, Testes, Breast

Animal Models for Necrotizing Sialometaplasia or affiliated genes

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Publications for Necrotizing Sialometaplasia

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52PubMed
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Articles related to Necrotizing Sialometaplasia:

(show top 50)    (show all 140)
idTitleAuthorsYear
1
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. (24353777)
2013
2
The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. (22921832)
2012
3
Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. (20403036)
2010
4
Necrotizing sialometaplasia of the parotid gland in a dog. (21088187)
2010
5
Necrotizing sialometaplasia: a practical approach to the diagnosis. (19415943)
2009
6
Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. (19482450)
2009
7
Case of the month. Necrotizing sialometaplasia. (18567189)
2008
8
Bilateral presentation of necrotizing sialometaplasia--a case report. (18087930)
2007
9
Necrotizing sialometaplasia: a potential diagnostic pitfall. (17044429)
2006
10
Necrotizing sialometaplasia: report of five cases. (15292869)
2004
11
Necrotizing sialometaplasia: a case report. (15503360)
2004
12
Subacute necrotizing sialadenitis: a form of necrotizing sialometaplasia? (12975270)
2003
13
A case of necrotizing sialometaplasia in the upper lip. (12970596)
2003
14
Oral pathology quiz #35. Case number 2. Necrotizing sialometaplasia. (16795953)
2002
15
Necrotizing sialometaplasia: report of a case after lower lip mucocele excision. (11117693)
2000
16
Oral pathology. Fall 1998 case of the month. Necrotizing sialometaplasia. (10596625)
1998
17
Necrotizing sialometaplasia: literature review and case reports. (8754467)
1996
18
Necrotizing sialometaplasia of the larynx. (8607453)
1996
19
Pathologic quiz case 1. Necrotizing sialometaplasia obscuring recurrent well-differentiated squamous cell carcinoma of the maxillary sinus. (7727094)
1995
20
Necrotizing sialometaplasia. (8084644)
1994
21
Necrotizing sialometaplasia (adenometaplasia) of the trachea. (8495967)
1993
22
Necrotizing sialometaplasia (adenometaplasia) of the trachea. (1398527)
1992
23
Necrotizing sialometaplasia. A clinicopathologic study of sixty-nine cases and review of the literature. (1923419)
1991
24
Necrotizing sialometaplasia: report of 12 new cases. (2248941)
1990
25
Necrotizing sialometaplasia occurring during pregnancy: report of a case. (3165123)
1988
26
Necrotizing sialometaplasia of major salivary glands. (3668381)
1987
27
Necrotizing sialometaplasia--a malignancy simulating oral lesion. (3458319)
1986
28
Necrotizing sialometaplasia of the nasal cavity. (3083385)
1986
29
Necrotizing sialometaplasia obscuring an underlying malignancy: report of a case. (3459842)
1986
30
Necrotizing sialometaplasia of palatal minor salivary glands: a report on 2 cases. (3855981)
1985
31
Necrotizing sialometaplasia. (6829370)
1983
32
Necrotizing sialometaplasia: report of five cases. (6836063)
1983
33
Necrotizing sialometaplasia: an early, nonulcerative presentation. (6952149)
1982
34
Necrotizing sialometaplasia. (7242209)
1981
35
Necrotizing sialometaplasia: literature review and presentation of five cases. (6944453)
1981
36
Necrotizing sialometaplasia in a patient with Buerger's disease and Raynaud's phenomenon. (6928308)
1980
37
Necrotizing sialometaplasia. (6951608)
1980
38
Necrotizing sialometaplasia: review of the literature and report of nonulcerative case. (286778)
1979
39
Necrotizing sialometaplasia. (285245)
1979
40
Necrotizing sialometaplasia: a result of ischemia? Report of two cases and review of the literature. (298661)
1979
41
Case for diagnosis. Necrotizing sialometaplasia, left hard palate. (113695)
1979
42
Necrotizing sialometaplasia affecting the minor labial glands. (284279)
1979
43
Necrotizing sialometaplasia. (299075)
1979
44
NECROTIZING SIALOMETAPLASIA. (269338)
1977
45
A patient with necrotizing sialometaplasia. (412803)
1977
46
Necrotizing sialometaplasia of the palate. (1066464)
1976
47
Necrotizing sialometaplasia. (1075246)
1976
48
Necrotizing sialometaplasia. Report of a case. (1164230)
1975
49
Necrotizing sialometaplasia. Report of five additional cases. (4524380)
1974
50
Necrotizing sialometaplasia. A disease simulating malignancy. (4716764)
1973

Variations for Necrotizing Sialometaplasia

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Expression for genes affiliated with Necrotizing Sialometaplasia

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Necrotizing Sialometaplasia

Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for genes affiliated with Necrotizing Sialometaplasia

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Sources:
50PathCards, 5Cell Signaling Technology, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN
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Compounds for genes affiliated with Necrotizing Sialometaplasia

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR
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Compounds related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1dutp459.6MKI67, TP53
2irinotecan45 51 1111.6MKI67, TP53
3mitomycin c459.5MKI67, TP53
4thymidylate459.5TP53, MKI67
5vincristine45 51 1111.5TP53, MKI67
6cyclophosphamide45 51 1111.4MKI67, TP53
75fluorouracil459.4TP53, MKI67
8tamoxifen45 51 29 1112.3MKI67, TP53
9paraffin459.3MKI67, TP53
10paclitaxel45 51 1111.2MKI67, TP53
11doxorubicin45 51 1111.0MKI67, TP53

GO Terms for genes affiliated with Necrotizing Sialometaplasia

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16Gene Ontology
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Cellular components related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:0057308.5CRTC1, TP53, MKI67
2nucleusGO:0056347.7CRTC1, MAML2, TP53, MKI67

Biological processes related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell proliferationGO:0082839.3TP53, MKI67
2Notch signaling pathwayGO:0072199.0MAML2, TP53
3positive regulation of transcription from RNA polymerase II promoterGO:0459448.4CRTC1, MAML2, TP53

Products for genes affiliated with Necrotizing Sialometaplasia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Necrotizing Sialometaplasia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet