MCID: NCR003
MIFTS: 30

Necrotizing Sialometaplasia malady

Summaries for Necrotizing Sialometaplasia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Necrotizing sialometaplasia (also spelled necrotising sialometaplasia) is a benign ulcerative lesion... more...

MalaCards: Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to squamous cell carcinoma and sickle cell anemia. An important gene associated with Necrotizing Sialometaplasia is TP53 (tumor protein p53), and among its related pathways is Notch signaling pathway. The compounds dutp and irinotecan have been mentioned in the context of this disorder. Affiliated tissues include tongue, salivary gland and breast.

Aliases & Classifications for Necrotizing Sialometaplasia

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 35MeSH, 57SNOMED-CT
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Aliases & Descriptions:

necrotizing sialometaplasia 8 10
sialometaplasia, necrotizing 61


External Ids:

Disease Ontology8 DOID:12901
SNOMED-CT57 109769000
MeSH35 D012797

Related Diseases for Necrotizing Sialometaplasia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma10.4
2sickle cell anemia10.2
3tracheitis10.2
4maxillary sinus squamous cell carcinoma10.2
5sialadenitis10.2
6raynaud disease10.2
7adenoid cystic carcinoma10.2
8myoepithelial carcinoma10.2
9adenosquamous carcinoma10.2
10adenocarcinoma10.2
11oral squamous cell carcinoma10.2
12warthin tumor10.2
13sinusitis10.2
14actinic keratosis10.0TP53
15esophageal cancer10.0TP53
16benign meningioma10.0MKI67
17keratoacanthoma10.0MKI67
18smooth muscle tumor10.0MKI67
19ductal carcinoma in situ10.0TP53
20leukoplakia10.0MKI67
21cervical squamous cell carcinoma10.0MKI67
22leiomyosarcoma10.0TP53
23ependymoma10.0MKI67
24cervical intraepithelial neoplasia10.0MKI67
25gastrointestinal stromal tumor10.0MKI67
26kidney cancer10.0TP53
27bladder transitional cell carcinoma10.0TP53, MKI67
28breast cancer, invasive ductal10.0TP53, MKI67
29barrett's esophagus10.0MKI67, TP53
30adrenocortical carcinoma10.0MKI67, TP53
31leukemia10.0TP53
32bladder carcinoma10.0MKI67, TP53
33anaplastic astrocytoma10.0TP53, MKI67
34basal cell carcinoma10.0MKI67, TP53
35transitional cell carcinoma10.0MKI67, TP53
36lacrimal gland cancer10.0CRTC1, MAML2
37cutaneous mucoepidermoid carcinoma10.0MAML2, CRTC1
38lipoadenoma10.0MAML2, CRTC1
39cervical adenosquamous carcinoma10.0CRTC1, MAML2
40epithelial-myoepithelial carcinoma10.0MAML2, CRTC1
41hidradenoma10.0MAML2, CRTC1
42oligodendroglioma10.0TP53, MKI67
43b-cell lymphomas10.0MKI67, TP53
44mucoepidermoid carcinoma10.0MAML2, MKI67, CRTC1

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to necrotizing sialometaplasia

Clinical Features for Necrotizing Sialometaplasia

Drugs & Therapeutics for Necrotizing Sialometaplasia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Necrotizing Sialometaplasia

Search NIH Clinical Center for Necrotizing Sialometaplasia

Search CenterWatch for Necrotizing Sialometaplasia

Genetic Tests for Necrotizing Sialometaplasia

Anatomical Context for Necrotizing Sialometaplasia

Sources:
33MalaCards
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MalaCards organs/tissues related to Necrotizing Sialometaplasia:

33
Tongue, Salivary gland, Breast, T cells, Trachea

Animal Models for Necrotizing Sialometaplasia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Necrotizing Sialometaplasia

Sources:
51PubMed
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Articles related to Necrotizing Sialometaplasia:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. (24353777)
2013
2
Necrotizing sialometaplasia in an HIV positive cocaine user: a case report. (24217688)
2013
3
HIF-1I+, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. (23837804)
2013
4
A case of necrotizing sialometaplasia involving bilateral parotid glands. (23159016)
2013
5
Necrotizing sialometaplasia within a benign mixed tumor of parotid gland. (22200659)
2012
6
Necrotizing sialometaplasia as a cause of a non-ulcerated nodule in the hard palate: a case report. (21861916)
2011
7
Necrotizing sialometaplasia of palate: a case report. (21977472)
2011
8
Case report of necrotizing sialometaplasia. (21217621)
2011
9
Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma. (19118785)
2009
10
Necrotizing sialometaplasia of tongue. (21886996)
2009
11
Bilateral localization of necrotizing sialometaplasia: a case report. (20184708)
2009
12
Case of the month. Necrotizing sialometaplasia. (18567189)
2008
13
Bilateral presentation of necrotizing sialometaplasia--a case report. (18087930)
2007
14
Necrotizing sialometaplasia versus invasive carcinoma of the head and neck: the use of myoepithelial markers and keratin subtypes as an adjunct to diagnosis. (17650214)
2007
15
Necrotizing sialometaplasia: a potential diagnostic pitfall. (17044429)
2006
16
Necrotizing sialometaplasia: report of five cases. (15292869)
2004
17
Subacute necrotizing sialadenitis: a form of necrotizing sialometaplasia? (12975270)
2003
18
Necrotizing sialometaplasia: report of a case after lower lip mucocele excision. (11117693)
2000
19
Necrotizing sialometaplasia in two patients with bulimia and chronic vomiting. (9869289)
1998
20
Experimental study on necrotizing sialometaplasia of the palate in rats. Role of local anesthetic injections. (8872232)
1996
21
Pathologic quiz case 1. Necrotizing sialometaplasia obscuring recurrent well-differentiated squamous cell carcinoma of the maxillary sinus. (7727094)
1995
22
Necrotizing Sialometaplasia after Silastic Ring Vertical Gastroplasty: Case Report and Review of Literature. (10733808)
1995
23
Canine necrotizing sialometaplasia: a case report and review of the literature. (7820759)
1995
24
Necrotizing sialometaplasia of the larynx. A report of two cases and a review of the literature. (7741108)
1995
25
Necrotizing sialometaplasia. (8084644)
1994
26
Necrotizing sialometaplasia (adenometaplasia) of the trachea. (8495967)
1993
27
Necrotizing sialometaplasia: a review and two case reports. (1521257)
1992
28
Necrotizing sialometaplasia in a patient with sickle-cell anemia. (2056377)
1991
29
Necrotizing sialometaplasia masquerading as residual cancer of the lip. (3178123)
1988
30
Necrotizing sialometaplasia of palatal minor salivary glands: a report on 2 cases. (3855981)
1985
31
Case of the month. Necrotizing sialometaplasia. (6592257)
1984
32
Necrotizing sialometaplasia: a diagnostic dilemma. (6584633)
1984
33
Necrotizing sialometaplasia: an early, nonulcerative presentation. (6952149)
1982
34
Necrotizing sialometaplasia of the nasal cavity. (7158708)
1982
35
Necrotizing sialometaplasia: literature review and presentation of five cases. (6944453)
1981
36
Necrotizing sialometaplasia in the setting of acute and chronic sinusitis. (7346696)
1981
37
Necrotizing sialometaplasia--a clinical entity for dental awareness. (6765804)
1981
38
Necrotizing sialometaplasia of the lip simulating squamous cell carcinoma. (7353814)
1980
39
Necrotizing sialometaplasia of the cheek: report of case and review of literature. (6929908)
1980
40
Necrotizing sialometaplasia: review of the literature and report of nonulcerative case. (286778)
1979
41
Necrotizing sialometaplasia. (285245)
1979
42
Necrotizing sialometaplasia. (299075)
1979
43
Necrotizing sialometaplasia after bronchoscopy. (290774)
1979
44
Necrotizing sialometaplasia. (284281)
1979
45
Early and late manifestations of necrotizing sialometaplasia. (280671)
1978
46
Necrotizing sialometaplasia: a source of confusion with carcinoma of the palate. (851091)
1977
47
Necrotizing sialometaplasia involving the mucous glands of the nasal cavity. (903148)
1977
48
Necrotizing sialometaplasia of the palate. (1066464)
1976
49
Necrotizing sialometaplasia of the palate. Ulcerative or necrotizing stage of leukokeratosis nicotina palati? (826493)
1976
50
Necrotizing sialometaplasia. Report of a case. (1164230)
1975

Genetic Variations for Necrotizing Sialometaplasia

Expression for genes affiliated with Necrotizing Sialometaplasia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Necrotizing Sialometaplasia

Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for genes affiliated with Necrotizing Sialometaplasia

Sources:
30KEGG, 38NCBI BioSystems Database
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Pathways related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4TP53, MAML2

Compounds for genes affiliated with Necrotizing Sialometaplasia

Sources:
45Novoseek, 50PharmGKB, 11DrugBank
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Compounds related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dutp459.2TP53, MKI67
2irinotecan45 50 1111.2TP53, MKI67
3mitomycin c459.1TP53, MKI67
4cyclophosphamide45 50 1111.1TP53, MKI67
5vincristine45 50 1111.0MKI67, TP53
6thymidylate458.8TP53, MKI67

GO Terms for genes affiliated with Necrotizing Sialometaplasia

Sources:
16Gene Ontology
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Biological processes related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:0459448.8TP53, MAML2, CRTC1

Products for genes affiliated with Necrotizing Sialometaplasia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Necrotizing Sialometaplasia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet