MCID: NCR003
MIFTS: 34

Necrotizing Sialometaplasia malady

Categories: Oral diseases

Aliases & Classifications for Necrotizing Sialometaplasia

Aliases & Descriptions for Necrotizing Sialometaplasia:

Name: Necrotizing Sialometaplasia 12 14
Sialometaplasia, Necrotizing 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12901
ICD10 33 K11.8
MeSH 42 D012797
SNOMED-CT 64 109769000
UMLS 69 C0037033

Summaries for Necrotizing Sialometaplasia

MalaCards based summary : Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to wolffian adnexal neoplasm and skin amelanotic melanoma. An important gene associated with Necrotizing Sialometaplasia is KRT5 (Keratin 5), and among its related pathways/superpathways are DNA Damage and Activation of BH3-only proteins. Affiliated tissues include salivary gland, t cells and trachea, and related phenotypes are digestive/alimentary and no phenotypic analysis

Wikipedia : 71 Necrotizing sialometaplasia (NS) is a benign, ulcerative lesion, usually located towards the back of the... more...

Related Diseases for Necrotizing Sialometaplasia

Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
id Related Disease Score Top Affiliating Genes
1 wolffian adnexal neoplasm 10.3 MKI67 TP53
2 skin amelanotic melanoma 10.3 KRT5 KRT7
3 radiculopathy 10.3 KRT7 TP63
4 liver fibrosarcoma 10.3 GFAP TP53
5 cervical adenoid cystic carcinoma 10.3 GFAP TP53
6 mucinous cystadenocarcinoma 10.3 ACTC1 MKI67
7 sclerosing breast papilloma 10.2 KRT5 KRT7 TP53
8 angiofollicular lymph hyperplasia 10.2 ACTC1 GFAP
9 benign ependymoma 10.2 KRT5 TP53 TP63
10 cellular ependymoma 10.2 KRT5 KRT7 TP53
11 scirrhous adenocarcinoma 10.2 ACTC1 KRT5 TP63
12 bronchitis 10.2 GFAP TP53
13 bile duct clear cell adenocarcinoma 10.2 GFAP TP53
14 growth retardation hydrocephaly lung hypoplasia 10.2 ACTC1 KRT7 TP53
15 small intestine leiomyoma 10.2 KRT5 TP53
16 vagina leiomyosarcoma 10.2 ACTC1 GFAP
17 malignant glioma 10.2 GZMB TIA1
18 alström syndrome 10.2 GZMB TIA1
19 childhood mediastinal neurogenic tumor 10.2 CRTC1 MAML2
20 malignant spindle cell melanoma 10.2 GZMB MKI67 TP53
21 spleen angiosarcoma 10.2 ACTC1 GFAP
22 carbon monoxide-induced parkinsonism 10.2 ACTC1 KIT
23 laryngeal mucoepidermoid carcinoma 10.2 KRT5 KRT7
24 spinal cord intramedullary teratoma 10.2 CD5 KRT5 TP53
25 optic papillitis 10.2 CD5 TIA1
26 skeletal muscle cancer 10.2 GZMB TIA1
27 linear lichen planus 10.2 GZMB TIA1 TP53
28 childhood medulloblastoma 10.2 GFAP TP53 TP63
29 cervical benign neoplasm 10.2 GFAP TP53
30 cauda equina intradural extramedullary astrocytoma 10.2 ACTC1 GFAP TP63
31 tibial adamantinoma 10.1 GZMB TIA1
32 conjunctival intraepithelial neoplasm 10.1 CRTC1 MAML2
33 heavy chain disease 10.1 GFAP KRT5 MAML2
34 ebola hemorrhagic fever 10.1 KRT5 KRT7
35 superior limbic keratoconjunctivitis 10.1 GZMB TIA1
36 multidrug-resistant tuberculosis 10.1 CRTC1 KRT5 MAML2
37 malignant teratoma 10.1 GZMB KRT7 TIA1
38 choriocarcinoma of ovary 10.1 KIT KRT5 TP53
39 myotonic disease 10.1 CD5 KRT5 KRT7
40 atypical lipomatous tumor 10.1 KIT TP63
41 clear cell adenofibroma 10.1 CDKN2A TP53
42 collagen type iii glomerulopathy 10.1 GZMB TIA1
43 lacrimal gland adenoid cystic carcinoma 10.1 CDKN2A TP53
44 juvenile astrocytoma 10.1 ACTC1 GFAP TP53
45 enchondromatosis dwarfism deafness 10.1 KIT MKI67 TP53
46 deep angioma 10.1 CRTC1 KRT7 MAML2
47 prostate lymphoma 10.1 KRT5 KRT7
48 pustulosis palmaris et plantaris 10.1 ACTC1 KIT MKI67
49 middle ear adenocarcinoma 10.1 KIT KRT5 KRT7
50 leiomyomatosis 10.1 GFAP KIT

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to Necrotizing Sialometaplasia

Symptoms & Phenotypes for Necrotizing Sialometaplasia

MGI Mouse Phenotypes related to Necrotizing Sialometaplasia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.63 CDKN2A GFAP KIT KRT5 TP53 TP63
2 no phenotypic analysis MP:0003012 9.43 CD5 CDKN2A KIT KRT5 TP53 TP63
3 normal MP:0002873 9.17 TP63 ACTC1 CD5 GFAP KIT MKI67

Drugs & Therapeutics for Necrotizing Sialometaplasia

Search Clinical Trials , NIH Clinical Center for Necrotizing Sialometaplasia

Cochrane evidence based reviews: sialometaplasia, necrotizing

Genetic Tests for Necrotizing Sialometaplasia

Anatomical Context for Necrotizing Sialometaplasia

MalaCards organs/tissues related to Necrotizing Sialometaplasia:

39
Salivary Gland, T Cells, Trachea, Tongue, Testes, Breast

Publications for Necrotizing Sialometaplasia

Articles related to Necrotizing Sialometaplasia:

(show top 50) (show all 161)
id Title Authors Year
1
Necrotizing sialometaplasia: Manifestation of a localized unclassified vasculitis. ( 27166051 )
2016
2
Necrotizing Sialometaplasia of the Hard Palate in a Patient Treated with Topical Nonsteroidal Anti-Inflammatory Drug. ( 27833767 )
2016
3
Necrotizing sialometaplasia of the lacrimal sac mimicking squamous cell carcinoma: Necrotizing dacyocystometaplasia. ( 26634609 )
2016
4
Necrotizing sialometaplasia related to vomiting and silastic ring vertical gastroplasty. ( 26504909 )
2015
5
Contralateral recurrence of necrotizing sialometaplasia of the hard palate after five months: a case report. ( 26734562 )
2015
6
Review of the literature on necrotizing sialometaplasia and case presentation. ( 25191669 )
2015
7
Surgical management of necrotizing sialometaplasia of palate. ( 26672431 )
2015
8
Necrotizing Sialometaplasia of the Hard Palate: A Rare Entity of Dilemma on Cytology, Confirmatory on Histopathology. ( 26816899 )
2015
9
Spontaneous necrotizing sialometaplasia of the submandibular salivary gland in a Beagle dog. ( 26441480 )
2015
10
Parotid necrotizing sialometaplasia vs infarcted Warthin tumour. ( 25564889 )
2015
11
Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature. ( 24634907 )
2014
12
Necrotizing sialometaplasia of the palatal mucosa in patient with history of anorexia: review and case report. ( 24667056 )
2014
13
Two rare entities in the same palate lesion: hyalinizing-type clear cell carcinoma and necrotizing sialometaplasia. ( 24820724 )
2014
14
Necrotizing sialometaplasia of the nasopharynx with parapharyngeal extension: Case report and brief review of the literature. ( 25531850 )
2014
15
Early references to necrotizing sialometaplasia. ( 24439923 )
2014
16
Imaging findings of necrotizing sialometaplasia of the parotid gland: case report and literature review. ( 24850145 )
2014
17
Necrotizing sialometaplasia: a diagnostic dilemma. ( 25284537 )
2014
18
Necrotizing sialometaplasia: A diagnostic dilemma! ( 25948999 )
2014
19
Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus. ( 24863247 )
2014
20
Necrotizing sialometaplasia: A rare lesion that mimics oral cancer clinically and histopathologically. ( 24837912 )
2014
21
Oral and maxillofacial pathology. Case of the month. Diagnosis: Necrotizing sialometaplasia. ( 23930450 )
2013
22
Mandibular fracture and necrotizing sialometaplasia in a rabbit. ( 23561940 )
2013
23
Necrotizing sialometaplasia in a patient with an eating disorder: palatal ulcer accompanied by dental erosion due to binge-purging. ( 23375898 )
2013
24
A case of necrotizing sialometaplasia involving bilateral parotid glands. ( 23159016 )
2013
25
HIF-1I+, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. ( 23837804 )
2013
26
Necrotizing sialometaplasia in an HIV positive cocaine user: a case report. ( 24217688 )
2013
27
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. ( 24353777 )
2013
28
CT findings of necrotizing sialometaplasia. ( 22074871 )
2012
29
Significance of Ki-67 and p53 immunoexpression in the differential diagnosis of oral necrotizing sialometaplasia and squamous cell carcinoma. ( 22197541 )
2012
30
Necrotizing sialometaplasia within a benign mixed tumor of parotid gland. ( 22200659 )
2012
31
Necrotizing sialometaplasia of palate: a case report. ( 22957289 )
2012
32
The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. ( 22921832 )
2012
33
Necrotizing sialometaplasia of palate: a case report. ( 21977472 )
2011
34
Case report of necrotizing sialometaplasia. ( 21217621 )
2011
35
Necrotizing sialometaplasia as a cause of a non-ulcerated nodule in the hard palate: a case report. ( 21861916 )
2011
36
Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. ( 20403036 )
2010
37
Necrotizing sialometaplasia of the parotid gland in a dog. ( 21088187 )
2010
38
A clinical case of necrotizing sialometaplasia and conjunctival hemorrhage. ( 20842082 )
2010
39
Necrotizing sialometaplasia in a patient who is HIV positive: a case report. ( 20618783 )
2010
40
Necrotizing sialometaplasia of bronchial mucosa. ( 19948640 )
2010
41
Necrotizing sialometaplasia-a practical approach to the diagnosis. ( 20073597 )
2010
42
Necrotizing sialometaplasia of tongue. ( 21886996 )
2009
43
Necrotizing sialometaplasia: a practical approach to the diagnosis. ( 19415943 )
2009
44
Necrotizing sialometaplasia accompanied by adenoid cystic carcinoma on the soft palate. ( 19434292 )
2009
45
Bilateral localization of necrotizing sialometaplasia: a case report. ( 20184708 )
2009
46
Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. ( 19482450 )
2009
47
Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma. ( 19118785 )
2009
48
Necrotizing sialometaplasia of the palate in a cocaine-using patient. A case report. ( 18427364 )
2008
49
Case report. MRI findings of necrotizing sialometaplasia. ( 18487385 )
2008
50
Case of the month. Necrotizing sialometaplasia. ( 18567189 )
2008

Variations for Necrotizing Sialometaplasia

Expression for Necrotizing Sialometaplasia

Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for Necrotizing Sialometaplasia

GO Terms for Necrotizing Sialometaplasia

Cellular components related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.65 ACTC1 CDKN2A CRTC1 GFAP GZMB KRT5
2 cytoplasm GO:0005737 9.4 ACTC1 CDKN2A CRTC1 GFAP GZMB KIT

Biological processes related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to X-ray GO:0010165 9.46 TP53 TP63
2 entrainment of circadian clock by photoperiod GO:0043153 9.43 CRTC1 TP53
3 apoptotic process GO:0006915 9.43 ACTC1 CDKN2A GZMB TIA1 TP53 TP63
4 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.4 TP53 TP63
5 replicative senescence GO:0090399 9.37 CDKN2A TP53
6 protein homotetramerization GO:0051289 9.33 CRTC1 TP53 TP63
7 mitotic G1 DNA damage checkpoint GO:0031571 9.32 TP53 TP63
8 somatic stem cell division GO:0048103 9.26 CDKN2A KIT
9 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 8.8 GZMB TP53 TP63

Sources for Necrotizing Sialometaplasia

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70 UMLS via Orphanet
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