MCID: NCR003
MIFTS: 33

Necrotizing Sialometaplasia

Categories: Oral diseases

Aliases & Classifications for Necrotizing Sialometaplasia

MalaCards integrated aliases for Necrotizing Sialometaplasia:

Name: Necrotizing Sialometaplasia 12 14
Sialometaplasia, Necrotizing 42 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12901
ICD10 33 K11.8
MeSH 42 D012797
SNOMED-CT 64 109769000
UMLS 69 C0037033

Summaries for Necrotizing Sialometaplasia

MalaCards based summary : Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to pediatric infratentorial ependymoma and small intestine leiomyoma. An important gene associated with Necrotizing Sialometaplasia is KRT5 (Keratin 5), and among its related pathways/superpathways are DNA Damage and Activation of BH3-only proteins. Affiliated tissues include salivary gland, t cells and trachea, and related phenotypes are digestive/alimentary and no phenotypic analysis

Wikipedia : 72 Necrotizing sialometaplasia (NS) is a benign, ulcerative lesion, usually located towards the back of the... more...

Related Diseases for Necrotizing Sialometaplasia

Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
id Related Disease Score Top Affiliating Genes
1 pediatric infratentorial ependymoma 10.9 MKI67 TP53
2 small intestine leiomyoma 10.8 KRT5 TP53
3 endometrial disease 10.8 KRT5 KRT7
4 hemangioma of liver 10.8 ACTC1 TP53
5 mucoepidermoid esophageal carcinoma 10.8 KRT5 KRT7
6 bone giant cell tumor 10.8 KRT7 TP63
7 familial periodic paralysis 10.8 KRT5 KRT7
8 acantholytic acanthoma 10.8 KRT5 KRT7
9 female breast axillary tail cancer 10.7 KRT5 KRT7
10 lobular neoplasia 10.7 KRT5 KRT7
11 berk-tabatznik syndrome 10.7 ACTC1 KRT7
12 pancoast tumor 10.7 GFAP TP53
13 brain stem astrocytic neoplasm 10.7 GFAP TP53
14 renal pelvis urothelial papilloma 10.7 GFAP TP53
15 tendon sheath lipoma 10.7 GFAP TP53
16 anaplastic plasmacytoma 10.6 ACTC1 GFAP
17 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.6 GFAP TP53
18 sebaceous adenocarcinoma 10.6 KRT5 TP53 TP63
19 brain glioma 10.6 GFAP TP53
20 fallopian tube germ cell cancer 10.6 ACTC1 TP63
21 lipid-cell variant infiltrating bladder urothelial carcinoma 10.6 KRT5 KRT7 TP53
22 esophagus leiomyosarcoma 10.6 ACTC1 GFAP
23 rh isoimmunization 10.6 GFAP TP53
24 spleen angiosarcoma 10.6 ACTC1 GFAP
25 iodine hypothyroidism 10.6 GFAP TP53
26 third cranial nerve disease 10.6 GFAP TP53
27 hypoglycemia 10.6 GZMB TIA1
28 male infertility 10.6 GZMB TIA1
29 laryngeal neuroendocrine tumor 10.6 ACTC1 GFAP
30 clivus chondroid chordoma 10.6 GZMB TIA1
31 succinic acidemia lactic acidosis congenital 10.6 GZMB TIA1
32 linitis plastica 10.6 ACTC1 KRT5 TP63
33 pleural empyema 10.6 GFAP TP53
34 limb-body wall complex 10.6 GZMB TP53
35 aggressive systemic mastocytosis 10.6 GFAP TP53
36 rubella panencephalitis 10.6 GZMB TIA1
37 gastrointestinal tuberculosis 10.6 GZMB TIA1
38 childhood choroid plexus cancer 10.5 GFAP TP53
39 brachial plexus neuritis 10.5 GFAP TP53
40 congenital sucrase-isomaltase deficiency with starch intolerance 10.5 GZMB TIA1
41 group b strep disease in newborns 10.5 ACTC1 KRT7 TP53
42 laryngeal mucoepidermoid carcinoma 10.5 CRTC1 MAML2
43 breast fibroadenosis 10.5 GZMB TIA1
44 subependymal giant cell astrocytoma 10.5 GFAP TP53
45 eccrine papillary adenoma 10.5 CRTC1 MAML2
46 intrahepatic cholangiocarcinoma 10.5 CD5 KRT7
47 hand dermatosis 10.5 GZMB MKI67 TP53
48 marfanoid habitus-inguinal hernia-advanced bone age syndrome 10.5 ACTC1 KIT
49 degenerative myopia 10.4 CD5 KRT7
50 clear cell squamous cell skin carcinoma 10.4 KIT KRT7

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to Necrotizing Sialometaplasia

Symptoms & Phenotypes for Necrotizing Sialometaplasia

MGI Mouse Phenotypes related to Necrotizing Sialometaplasia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.63 CDKN2A GFAP KIT KRT5 TP53 TP63
2 no phenotypic analysis MP:0003012 9.43 CDKN2A KIT KRT5 TP53 TP63 CD5
3 normal MP:0002873 9.17 ACTC1 CD5 GFAP KIT MKI67 TP53

Drugs & Therapeutics for Necrotizing Sialometaplasia

Search Clinical Trials , NIH Clinical Center for Necrotizing Sialometaplasia

Cochrane evidence based reviews: sialometaplasia, necrotizing

Genetic Tests for Necrotizing Sialometaplasia

Anatomical Context for Necrotizing Sialometaplasia

MalaCards organs/tissues related to Necrotizing Sialometaplasia:

39
Salivary Gland, T Cells, Trachea, Tongue, Testes, Breast

Publications for Necrotizing Sialometaplasia

Articles related to Necrotizing Sialometaplasia:

(show top 50) (show all 162)
id Title Authors Year
1
Necrotizing sialometaplasia of the parotid gland associated with facial nerve paralysis. ( 28330578 )
2017
2
Necrotizing Sialometaplasia of the Hard Palate in a Patient Treated with Topical Nonsteroidal Anti-Inflammatory Drug. ( 27833767 )
2016
3
Necrotizing sialometaplasia: Manifestation of a localized unclassified vasculitis. ( 27166051 )
2016
4
Necrotizing sialometaplasia of the lacrimal sac mimicking squamous cell carcinoma: Necrotizing dacyocystometaplasia. ( 26634609 )
2016
5
Spontaneous necrotizing sialometaplasia of the submandibular salivary gland in a Beagle dog. ( 26441480 )
2015
6
Necrotizing sialometaplasia related to vomiting and silastic ring vertical gastroplasty. ( 26504909 )
2015
7
Review of the literature on necrotizing sialometaplasia and case presentation. ( 25191669 )
2015
8
Contralateral recurrence of necrotizing sialometaplasia of the hard palate after five months: a case report. ( 26734562 )
2015
9
Surgical management of necrotizing sialometaplasia of palate. ( 26672431 )
2015
10
Necrotizing Sialometaplasia of the Hard Palate: A Rare Entity of Dilemma on Cytology, Confirmatory on Histopathology. ( 26816899 )
2015
11
Parotid necrotizing sialometaplasia vs infarcted Warthin tumour. ( 25564889 )
2015
12
Necrotizing sialometaplasia of the palatal mucosa in patient with history of anorexia: review and case report. ( 24667056 )
2014
13
Necrotizing sialometaplasia of the nasopharynx with parapharyngeal extension: Case report and brief review of the literature. ( 25531850 )
2014
14
Necrotizing sialometaplasia: a diagnostic dilemma. ( 25284537 )
2014
15
Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus. ( 24863247 )
2014
16
Imaging findings of necrotizing sialometaplasia of the parotid gland: case report and literature review. ( 24850145 )
2014
17
Necrotizing sialometaplasia: A diagnostic dilemma! ( 25948999 )
2014
18
Two rare entities in the same palate lesion: hyalinizing-type clear cell carcinoma and necrotizing sialometaplasia. ( 24820724 )
2014
19
Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature. ( 24634907 )
2014
20
Early references to necrotizing sialometaplasia. ( 24439923 )
2014
21
Necrotizing sialometaplasia: A rare lesion that mimics oral cancer clinically and histopathologically. ( 24837912 )
2014
22
A case of necrotizing sialometaplasia involving bilateral parotid glands. ( 23159016 )
2013
23
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. ( 24353777 )
2013
24
HIF-1I+, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. ( 23837804 )
2013
25
Necrotizing sialometaplasia in a patient with an eating disorder: palatal ulcer accompanied by dental erosion due to binge-purging. ( 23375898 )
2013
26
Mandibular fracture and necrotizing sialometaplasia in a rabbit. ( 23561940 )
2013
27
Oral and maxillofacial pathology. Case of the month. Diagnosis: Necrotizing sialometaplasia. ( 23930450 )
2013
28
Necrotizing sialometaplasia in an HIV positive cocaine user: a case report. ( 24217688 )
2013
29
Significance of Ki-67 and p53 immunoexpression in the differential diagnosis of oral necrotizing sialometaplasia and squamous cell carcinoma. ( 22197541 )
2012
30
Necrotizing sialometaplasia of palate: a case report. ( 22957289 )
2012
31
Necrotizing sialometaplasia within a benign mixed tumor of parotid gland. ( 22200659 )
2012
32
CT findings of necrotizing sialometaplasia. ( 22074871 )
2012
33
The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. ( 22921832 )
2012
34
Necrotizing sialometaplasia of palate: a case report. ( 21977472 )
2011
35
Case report of necrotizing sialometaplasia. ( 21217621 )
2011
36
Necrotizing sialometaplasia as a cause of a non-ulcerated nodule in the hard palate: a case report. ( 21861916 )
2011
37
Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. ( 20403036 )
2010
38
Necrotizing sialometaplasia of the parotid gland in a dog. ( 21088187 )
2010
39
Necrotizing sialometaplasia in a patient who is HIV positive: a case report. ( 20618783 )
2010
40
Necrotizing sialometaplasia of bronchial mucosa. ( 19948640 )
2010
41
Necrotizing sialometaplasia-a practical approach to the diagnosis. ( 20073597 )
2010
42
A clinical case of necrotizing sialometaplasia and conjunctival hemorrhage. ( 20842082 )
2010
43
Necrotizing sialometaplasia accompanied by adenoid cystic carcinoma on the soft palate. ( 19434292 )
2009
44
Bilateral localization of necrotizing sialometaplasia: a case report. ( 20184708 )
2009
45
Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma. ( 19118785 )
2009
46
Necrotizing sialometaplasia: a practical approach to the diagnosis. ( 19415943 )
2009
47
Necrotizing sialometaplasia of tongue. ( 21886996 )
2009
48
Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. ( 19482450 )
2009
49
Case report. MRI findings of necrotizing sialometaplasia. ( 18487385 )
2008
50
Necrotizing sialometaplasia of the palate in a cocaine-using patient. A case report. ( 18427364 )
2008

Variations for Necrotizing Sialometaplasia

Expression for Necrotizing Sialometaplasia

Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for Necrotizing Sialometaplasia

GO Terms for Necrotizing Sialometaplasia

Cellular components related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.7 ACTC1 CDKN2A CRTC1 GFAP KIT KRT5
2 cytosol GO:0005829 9.32 ACTC1 CDKN2A CRTC1 GFAP GZMB KRT5

Biological processes related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.61 ACTC1 KIT TP53
2 entrainment of circadian clock by photoperiod GO:0043153 9.46 CRTC1 TP53
3 apoptotic process GO:0006915 9.43 ACTC1 CDKN2A GZMB TIA1 TP53 TP63
4 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.4 TP53 TP63
5 replicative senescence GO:0090399 9.37 CDKN2A TP53
6 protein homotetramerization GO:0051289 9.33 CRTC1 TP53 TP63
7 mitotic G1 DNA damage checkpoint GO:0031571 9.32 TP53 TP63
8 somatic stem cell division GO:0048103 9.26 CDKN2A KIT
9 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 8.8 GZMB TP53 TP63

Sources for Necrotizing Sialometaplasia

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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
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32 HPO
33 ICD10
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42 MeSH
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65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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