MCID: NCR003
MIFTS: 34

Necrotizing Sialometaplasia malady

Category: Oral diseases

Aliases & Classifications for Necrotizing Sialometaplasia

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Aliases & Descriptions for Necrotizing Sialometaplasia:

Name: Necrotizing Sialometaplasia 11 13
 
Sialometaplasia, Necrotizing 39 68

Classifications:



External Ids:

Disease Ontology11 DOID:12901
ICD1030 K11.8
SNOMED-CT62 109769000
MeSH39 D012797

Summaries for Necrotizing Sialometaplasia

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Wikipedia:71 Necrotizing sialometaplasia (NS) is a benign, ulcerative lesion, usually located towards the back of the... more...

MalaCards based summary: Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to peptic ulcer disease and cryptosporidiosis. An important gene associated with Necrotizing Sialometaplasia is KRT5 (Keratin 5), and among its related pathways are Inhibition of Ribosome Biogenesis by p14(ARF) and Activation of BH3-only proteins. Affiliated tissues include salivary gland, trachea and tongue, and related mouse phenotypes are digestive/alimentary and muscle.

Related Diseases for Necrotizing Sialometaplasia

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Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1peptic ulcer disease10.7MKI67, TP53
2cryptosporidiosis10.7KRT5, TP53
3mushroom workers' lung10.7ACTC1, TP53
4signet ring basal cell carcinoma10.6KRT7, TP63
5lacrimal gland mucoepidermoid carcinoma10.6KRT5, KRT7
6placental site trophoblastic tumor10.6ACTC1, MKI67
7familial periodic paralysis10.6KRT5, KRT7
8epidermolytic acanthoma10.6KRT5, KRT7
9female breast lower-inner quadrant cancer10.6KRT5, KRT7
10breast neuroendocrine neoplasm10.6KRT5, KRT7
11eccrine papillary adenoma10.6ACTC1, TP53
12mollaret meningitis10.6ACTC1, KRT7
13skin meningioma10.6GFAP, TP53
14vulvar alveolar soft part sarcoma10.6ACTC1, TP63
15glomeruloid hemangioma10.6GFAP, TP53
16infiltrating lipoma10.5GFAP, TP53
17renal pelvis inverted papilloma10.5GFAP, TP53
18skin glomangioma10.5ACTC1, TP53
19brain glioma10.5GFAP, TP53
20vulvar benign neoplasm10.5GFAP, TP53
21hypersensitivity reaction type ii disease10.5GFAP, TP53
22brainstem intraparenchymal clear cell meningioma10.5GFAP, TP53
23anaplastic oligodendroglioma10.5ACTC1, GFAP
24yolk sac tumor of central nervous system10.5GFAP, TP53
25tamoxifen-related endometrial lesion10.5KRT5, KRT7, TP53
26atypical choroid plexus papilloma10.5GFAP, TP53
27external ear disease10.5GFAP, TP53
28ganglioglioma10.5GFAP, TP53
29chondroblastoma10.5ACTC1, GFAP
30male infertility10.5GZMB, TIA1
31mast-cell sarcoma10.5KRT5, KRT7
32eosinophilia10.5GZMB, TIA1
33pulmonary venoocclusive disease10.5ACTC1, GFAP
34subependymal nodular heterotopia10.5GZMB, TIA1
35pseudotyphus of california10.5GZMB, TIA1
36granulomatous gastritis10.5GZMB, TIA1
37clivus chordoma10.5GZMB, TIA1
38plexopathy10.4GFAP, TP53
39diffuse large b-cell lymphoma with chronic inflammation10.4GZMB, TIA1
40polycystic ovary syndrome10.4GZMB, TIA1
41paranasal sinus cancer, adult10.4ACTC1, KRT7, TP53
42mucoepidermoid thyroid carcinoma10.4CRTC1, MAML2
43xq12-q13.3 duplication syndrome10.4ACTC1, KIT
44malignant pineal area germ cell neoplasm10.4GFAP, TP53
45breast fibroadenosis10.4GZMB, TIA1
46syringocystadenoma papilliferum10.4CRTC1, MAML2
47diencephalic astrocytomas10.4GFAP, TP53
48multicentric reticulohistiocytosis10.4CD5, KRT7
49benign angiitis of the central nervous system10.4CD5, TP53
50adult choroid plexus cancer10.4GFAP, TP53

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to necrotizing sialometaplasia

Symptoms & Phenotypes for Necrotizing Sialometaplasia

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MGI Mouse Phenotypes related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.0CDKN2A, GFAP, KIT, KRT5, TP53, TP63
2MP:00053698.9ACTC1, CDKN2A, GFAP, KIT, TP53, TP63
3MP:00030128.8CD5, CDKN2A, KIT, KRT5, TP53, TP63
4MP:00028738.0ACTC1, CD5, GFAP, KIT, MKI67, TP53
5MP:00053787.8ACTC1, CDKN2A, CRTC1, GFAP, KIT, KRT5

Drugs & Therapeutics for Necrotizing Sialometaplasia

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Necrotizing Sialometaplasia


Cochrane evidence based reviews: sialometaplasia, necrotizing

Genetic Tests for Necrotizing Sialometaplasia

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Anatomical Context for Necrotizing Sialometaplasia

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MalaCards organs/tissues related to Necrotizing Sialometaplasia:

36
Salivary gland, Trachea, Tongue, T cells, Testes

Publications for Necrotizing Sialometaplasia

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Articles related to Necrotizing Sialometaplasia:

(show top 50)    (show all 161)
idTitleAuthorsYear
1
Necrotizing Sialometaplasia of the Hard Palate in a Patient Treated with Topical Nonsteroidal Anti-Inflammatory Drug. (27833767)
2016
2
Necrotizing sialometaplasia: Manifestation of a localized unclassified vasculitis. (27166051)
2016
3
Necrotizing sialometaplasia of the lacrimal sac mimicking squamous cell carcinoma: Necrotizing dacyocystometaplasia. (26634609)
2016
4
Contralateral recurrence of necrotizing sialometaplasia of the hard palate after five months: a case report. (26734562)
2015
5
Spontaneous necrotizing sialometaplasia of the submandibular salivary gland in a Beagle dog. (26441480)
2015
6
Review of the literature on necrotizing sialometaplasia and case presentation. (25191669)
2015
7
Parotid necrotizing sialometaplasia vs infarcted Warthin tumour. (25564889)
2015
8
Surgical management of necrotizing sialometaplasia of palate. (26672431)
2015
9
Necrotizing sialometaplasia related to vomiting and silastic ring vertical gastroplasty. (26504909)
2015
10
Necrotizing Sialometaplasia of the Hard Palate: A Rare Entity of Dilemma on Cytology, Confirmatory on Histopathology. (26816899)
2015
11
Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature. (24634907)
2014
12
Necrotizing sialometaplasia: a diagnostic dilemma. (25284537)
2014
13
Necrotizing sialometaplasia: A rare lesion that mimics oral cancer clinically and histopathologically. (24837912)
2014
14
Imaging findings of necrotizing sialometaplasia of the parotid gland: case report and literature review. (24850145)
2014
15
Necrotizing sialometaplasia-like change of the esophageal submucosal glands is associated with Barrett's esophagus. (24863247)
2014
16
Necrotizing sialometaplasia of the palatal mucosa in patient with history of anorexia: review and case report. (24667056)
2014
17
Necrotizing sialometaplasia of the nasopharynx with parapharyngeal extension: Case report and brief review of the literature. (25531850)
2014
18
Necrotizing sialometaplasia: A diagnostic dilemma! (25948999)
2014
19
Early references to necrotizing sialometaplasia. (24439923)
2014
20
Two rare entities in the same palate lesion: hyalinizing-type clear cell carcinoma and necrotizing sialometaplasia. (24820724)
2014
21
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. (24353777)
2013
22
Necrotizing sialometaplasia in an HIV positive cocaine user: a case report. (24217688)
2013
23
Necrotizing sialometaplasia in a patient with an eating disorder: palatal ulcer accompanied by dental erosion due to binge-purging. (23375898)
2013
24
HIF-1I+, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. (23837804)
2013
25
Mandibular fracture and necrotizing sialometaplasia in a rabbit. (23561940)
2013
26
Oral and maxillofacial pathology. Case of the month. Diagnosis: Necrotizing sialometaplasia. (23930450)
2013
27
A case of necrotizing sialometaplasia involving bilateral parotid glands. (23159016)
2013
28
The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. (22921832)
2012
29
Necrotizing sialometaplasia within a benign mixed tumor of parotid gland. (22200659)
2012
30
CT findings of necrotizing sialometaplasia. (22074871)
2012
31
Significance of Ki-67 and p53 immunoexpression in the differential diagnosis of oral necrotizing sialometaplasia and squamous cell carcinoma. (22197541)
2012
32
Necrotizing sialometaplasia of palate: a case report. (22957289)
2012
33
Necrotizing sialometaplasia as a cause of a non-ulcerated nodule in the hard palate: a case report. (21861916)
2011
34
Necrotizing sialometaplasia of palate: a case report. (21977472)
2011
35
Case report of necrotizing sialometaplasia. (21217621)
2011
36
Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. (20403036)
2010
37
Necrotizing sialometaplasia of the parotid gland in a dog. (21088187)
2010
38
Necrotizing sialometaplasia-a practical approach to the diagnosis. (20073597)
2010
39
Necrotizing sialometaplasia in a patient who is HIV positive: a case report. (20618783)
2010
40
Necrotizing sialometaplasia of bronchial mucosa. (19948640)
2010
41
A clinical case of necrotizing sialometaplasia and conjunctival hemorrhage. (20842082)
2010
42
Necrotizing sialometaplasia: a practical approach to the diagnosis. (19415943)
2009
43
Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. (19482450)
2009
44
Necrotizing sialometaplasia of the palate associated with angiocentric T-cell lymphoma. (19118785)
2009
45
Necrotizing sialometaplasia of tongue. (21886996)
2009
46
Bilateral localization of necrotizing sialometaplasia: a case report. (20184708)
2009
47
Necrotizing sialometaplasia accompanied by adenoid cystic carcinoma on the soft palate. (19434292)
2009
48
Case of the month. Necrotizing sialometaplasia. (18567189)
2008
49
Necrotizing sialometaplasia of the palate in a cocaine-using patient. A case report. (18427364)
2008
50
Case report. MRI findings of necrotizing sialometaplasia. (18487385)
2008

Variations for Necrotizing Sialometaplasia

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Expression for genes affiliated with Necrotizing Sialometaplasia

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Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for genes affiliated with Necrotizing Sialometaplasia

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GO Terms for genes affiliated with Necrotizing Sialometaplasia

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Cellular components related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.0GFAP, KRT5, KRT7
2cytoplasmGO:00057376.1ACTC1, CDKN2A, CRTC1, GFAP, GZMB, KIT

Biological processes related to Necrotizing Sialometaplasia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.5TP53, TP63
2mitotic G1 DNA damage checkpointGO:003157110.4TP53, TP63
3entrainment of circadian clock by photoperiodGO:004315310.2CRTC1, TP53
4positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathwayGO:190074010.0GZMB, TP53, TP63
5replicative senescenceGO:009039910.0CDKN2A, TP53
6response to X-rayGO:00101659.9TP53, TP63

Sources for Necrotizing Sialometaplasia

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet