MCID: NCR003
MIFTS: 37

Necrotizing Sialometaplasia malady

Oral diseases category
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Summaries for Necrotizing Sialometaplasia

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Wikipedia:65 Necrotizing sialometaplasia (also spelled necrotising sialometaplasia) is a benign ulcerative lesion... more...

MalaCards based summary: Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to barrett's esophagus and papilloma. An important gene associated with Necrotizing Sialometaplasia is MKI67 (marker of proliferation Ki-67), and among its related pathways are Cell Cycle / Checkpoint Control and Pre-NOTCH Expression and Processing. The compounds dutp and irinotecan have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, t cells and tongue.

Aliases & Classifications for Necrotizing Sialometaplasia

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Necrotizing Sialometaplasia, Aliases & Descriptions:

Name: Necrotizing Sialometaplasia 8 10
 
Sialometaplasia, Necrotizing 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Oral diseases


External Ids:

Disease Ontology8 DOID:12901
SNOMED-CT57 109769000
MeSH34 D012797

Related Diseases for Necrotizing Sialometaplasia

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Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to necrotizing sialometaplasia

Symptoms for Necrotizing Sialometaplasia

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Drugs & Therapeutics for Necrotizing Sialometaplasia

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Drug clinical trials:

Search ClinicalTrials for Necrotizing Sialometaplasia

Search NIH Clinical Center for Necrotizing Sialometaplasia

Genetic Tests for Necrotizing Sialometaplasia

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Anatomical Context for Necrotizing Sialometaplasia

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MalaCards organs/tissues related to Necrotizing Sialometaplasia:

32
Salivary gland, T cells, Tongue, Trachea, Breast, Testes

Animal Models for Necrotizing Sialometaplasia or affiliated genes

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Publications for Necrotizing Sialometaplasia

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Articles related to Necrotizing Sialometaplasia:

(show top 50)    (show all 149)
idTitleAuthorsYear
1
Bilateral necrotizing sialometaplasia of the hard palate in a patient with bulimia: a case report and review of the literature. (24634907)
2014
2
Necrotizing sialometaplasia: a diagnostic dilemma. (25284537)
2014
3
Necrotizing sialometaplasia: A rare lesion that mimics oral cancer clinically and histopathologically. (24837912)
2014
4
Early references to necrotizing sialometaplasia. (24439923)
2014
5
Salivary gland tumors in patients with necrotizing sialometaplasia: a case series. (24353777)
2013
6
The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. (22921832)
2012
7
Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. (20403036)
2010
8
Necrotizing sialometaplasia of the parotid gland in a dog. (21088187)
2010
9
Necrotizing sialometaplasia: a practical approach to the diagnosis. (19415943)
2009
10
Adenosquamous carcinoma of the larynx associated with necrotizing sialometaplasia--a diagnostic challenge. (19482450)
2009
11
Case of the month. Necrotizing sialometaplasia. (18567189)
2008
12
Bilateral presentation of necrotizing sialometaplasia--a case report. (18087930)
2007
13
Necrotizing sialometaplasia: a potential diagnostic pitfall. (17044429)
2006
14
Necrotizing sialometaplasia: report of five cases. (15292869)
2004
15
Necrotizing sialometaplasia: a case report. (15503360)
2004
16
Subacute necrotizing sialadenitis: a form of necrotizing sialometaplasia? (12975270)
2003
17
A case of necrotizing sialometaplasia in the upper lip. (12970596)
2003
18
Oral pathology quiz #35. Case number 2. Necrotizing sialometaplasia. (16795953)
2002
19
Necrotizing sialometaplasia: report of a case after lower lip mucocele excision. (11117693)
2000
20
Oral pathology. Fall 1998 case of the month. Necrotizing sialometaplasia. (10596625)
1998
21
Necrotizing sialometaplasia: literature review and case reports. (8754467)
1996
22
Necrotizing sialometaplasia of the larynx. (8607453)
1996
23
Pathologic quiz case 1. Necrotizing sialometaplasia obscuring recurrent well-differentiated squamous cell carcinoma of the maxillary sinus. (7727094)
1995
24
Necrotizing sialometaplasia. (8084644)
1994
25
Necrotizing sialometaplasia (adenometaplasia) of the trachea. (8495967)
1993
26
Necrotizing sialometaplasia (adenometaplasia) of the trachea. (1398527)
1992
27
Necrotizing sialometaplasia occurring during pregnancy: report of a case. (3165123)
1988
28
Necrotizing sialometaplasia of major salivary glands. (3668381)
1987
29
Necrotizing sialometaplasia--a malignancy simulating oral lesion. (3458319)
1986
30
Necrotizing sialometaplasia of the nasal cavity. (3083385)
1986
31
Necrotizing sialometaplasia obscuring an underlying malignancy: report of a case. (3459842)
1986
32
Necrotizing sialometaplasia of palatal minor salivary glands: a report on 2 cases. (3855981)
1985
33
Necrotizing sialometaplasia. (6829370)
1983
34
Necrotizing sialometaplasia: an early, nonulcerative presentation. (6952149)
1982
35
Necrotizing sialometaplasia. (7242209)
1981
36
Necrotizing sialometaplasia: literature review and presentation of five cases. (6944453)
1981
37
Necrotizing sialometaplasia in a patient with Buerger's disease and Raynaud's phenomenon. (6928308)
1980
38
Necrotizing sialometaplasia. (6951608)
1980
39
Necrotizing sialometaplasia: review of the literature and report of nonulcerative case. (286778)
1979
40
Necrotizing sialometaplasia. (285245)
1979
41
Necrotizing sialometaplasia: a result of ischemia? Report of two cases and review of the literature. (298661)
1979
42
Case for diagnosis. Necrotizing sialometaplasia, left hard palate. (113695)
1979
43
Necrotizing sialometaplasia affecting the minor labial glands. (284279)
1979
44
Necrotizing sialometaplasia. (299075)
1979
45
NECROTIZING SIALOMETAPLASIA. (269338)
1977
46
Necrotizing sialometaplasia of the palate. (1066464)
1976
47
Necrotizing sialometaplasia. (1075246)
1976
48
Necrotizing sialometaplasia. Report of a case. (1164230)
1975
49
Necrotizing sialometaplasia. Report of five additional cases. (4524380)
1974
50
Necrotizing sialometaplasia. A disease simulating malignancy. (4716764)
1973

Variations for Necrotizing Sialometaplasia

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Expression for genes affiliated with Necrotizing Sialometaplasia

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Expression patterns in normal tissues for genes affiliated with Necrotizing Sialometaplasia

Search GEO for disease gene expression data for Necrotizing Sialometaplasia.

Pathways for genes affiliated with Necrotizing Sialometaplasia

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Compounds for genes affiliated with Necrotizing Sialometaplasia

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 28IUPHAR
See all sources

Compounds related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1dutp449.6TP53, MKI67
2irinotecan44 50 1111.6TP53, MKI67
3mitomycin c449.5MKI67, TP53
4thymidylate449.5TP53, MKI67
5vincristine44 50 1111.5TP53, MKI67
6cyclophosphamide44 50 1111.4MKI67, TP53
75fluorouracil449.4TP53, MKI67
8tamoxifen44 50 28 1112.3TP53, MKI67
9paraffin449.3TP53, MKI67
10paclitaxel44 50 1111.2MKI67, TP53
11doxorubicin44 50 1111.0TP53, MKI67

GO Terms for genes affiliated with Necrotizing Sialometaplasia

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Cellular components related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:0057308.5CRTC1, TP53, MKI67
2nucleusGO:0056347.7CRTC1, MAML2, TP53, MKI67

Biological processes related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell proliferationGO:0082839.3TP53, MKI67
2Notch signaling pathwayGO:0072199.0MAML2, TP53
3positive regulation of transcription from RNA polymerase II promoterGO:0459448.4CRTC1, MAML2, TP53

Products for genes affiliated with Necrotizing Sialometaplasia

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  • Antibodies
  • Proteins
  • Lysates

Sources for Necrotizing Sialometaplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet