MCID: NCR003
MIFTS: 32

Necrotizing Sialometaplasia malady

Summaries for Necrotizing Sialometaplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Necrotizing sialometaplasia (also spelled necrotising sialometaplasia) is a benign ulcerative lesion... more...

MalaCards: Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to squamous cell carcinoma and sickle cell anemia. An important gene associated with Necrotizing Sialometaplasia is TP53 (tumor protein p53), and among its related pathways is Notch signaling pathway. The compounds dutp and irinotecan have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, t cells and tongue.

Aliases & Classifications for Necrotizing Sialometaplasia

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

necrotizing sialometaplasia 8 10
sialometaplasia, necrotizing 60


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Disease Ontology8 DOID:12901
SNOMED-CT56 109769000
MeSH34 D012797

Related Diseases for Necrotizing Sialometaplasia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma10.4
2sickle cell anemia10.1
3tracheitis10.1
4maxillary sinus squamous cell carcinoma10.1
5sialadenitis10.1
6adenoid cystic carcinoma10.1
7adenosquamous carcinoma10.1
8adenoiditis10.1
9adenocarcinoma10.1
10eating disorder10.1
11esophagus adenocarcinoma10.1
12ischemia10.1
13lip cancer10.1
14actinic keratosis10.0TP53
15esophageal cancer10.0TP53
16benign meningioma10.0MKI67
17keratoacanthoma10.0MKI67
18smooth muscle tumor10.0MKI67
19ductal carcinoma in situ10.0TP53
20leukoplakia10.0MKI67
21cervical squamous cell carcinoma10.0MKI67
22leiomyosarcoma10.0TP53
23ependymoma10.0MKI67
24cervical intraepithelial neoplasia10.0MKI67
25gastrointestinal stromal tumor10.0MKI67
26kidney cancer10.0TP53
27bladder transitional cell carcinoma10.0TP53, MKI67
28breast cancer, invasive ductal10.0TP53, MKI67
29barrett's esophagus10.0MKI67, TP53
30adrenocortical carcinoma10.0MKI67, TP53
31leukemia10.0TP53
32bladder carcinoma10.0MKI67, TP53
33anaplastic astrocytoma10.0TP53, MKI67
34basal cell carcinoma10.0MKI67, TP53
35transitional cell carcinoma10.0MKI67, TP53
36lacrimal gland cancer10.0CRTC1, MAML2
37cutaneous mucoepidermoid carcinoma10.0MAML2, CRTC1
38lipoadenoma10.0MAML2, CRTC1
39cervical adenosquamous carcinoma10.0CRTC1, MAML2
40epithelial-myoepithelial carcinoma10.0MAML2, CRTC1
41hidradenoma10.0MAML2, CRTC1
42oligodendroglioma10.0TP53, MKI67
43b-cell lymphomas10.0MKI67, TP53
44mucoepidermoid carcinoma10.0MAML2, MKI67, CRTC1

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to necrotizing sialometaplasia

Clinical Features for Necrotizing Sialometaplasia

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Drugs & Therapeutics for Necrotizing Sialometaplasia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Necrotizing Sialometaplasia

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Anatomical Context for Necrotizing Sialometaplasia

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32MalaCards
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MalaCards organs/tissues related to Necrotizing Sialometaplasia:

32
Salivary gland, T cells, Tongue, Trachea, Breast, Testes

Animal Models for Necrotizing Sialometaplasia or affiliated genes

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Publications for Necrotizing Sialometaplasia

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50PubMed
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Articles related to Necrotizing Sialometaplasia:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Necrotizing sialometaplasia in a patient with an eating disorder: palatal ulcer accompanied by dental erosion due to binge-purging. (23375898)
2013
2
HIF-1I+, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. (23837804)
2013
3
A case of necrotizing sialometaplasia involving bilateral parotid glands. (23159016)
2013
4
Mandibular fracture and necrotizing sialometaplasia in a rabbit. (23561940)
2013
5
The clinical, histologic, and treatment spectrum in necrotizing sialometaplasia. (22921832)
2012
6
Necrotizing sialometaplasia of the parotid gland associated with angiocentric T-cell lymphoma: a case report and review of the literature. (20403036)
2010
7
Necrotizing sialometaplasia-a practical approach to the diagnosis. (20073597)
2010
8
Necrotizing sialometaplasia accompanied by adenoid cystic carcinoma on the soft palate. (19434292)
2009
9
Necrotizing sialometaplasia of tongue. (21886996)
2009
10
Bilateral localization of necrotizing sialometaplasia: a case report. (20184708)
2009
11
Case report. MRI findings of necrotizing sialometaplasia. (18487385)
2008
12
Necrotizing sialometaplasia versus invasive carcinoma of the head and neck: the use of myoepithelial markers and keratin subtypes as an adjunct to diagnosis. (17650214)
2007
13
Necrotizing sialometaplasia: a potential diagnostic pitfall. (17044429)
2006
14
Diagnostic quiz. Case no. 2: acute necrotizing sialometaplasia. (17939178)
2006
15
Necrotizing sialometaplasia: an unusual bilateral presentation associated with antecedent anaesthesia and lack of response to intralesional steroids. Case report and review of the literature. (14739958)
2004
16
Subacute necrotizing sialadenitis: a form of necrotizing sialometaplasia? (12975270)
2003
17
Necrotizing sialometaplasia of parotid gland: a possible vasculitic cause. (12049830)
2002
18
Necrotizing sialometaplasia: report of a case after lower lip mucocele excision. (11117693)
2000
19
Experimental study on necrotizing sialometaplasia of the palate in rats. Role of local anesthetic injections. (8872232)
1996
20
Pathologic quiz case 1. Necrotizing sialometaplasia obscuring recurrent well-differentiated squamous cell carcinoma of the maxillary sinus. (7727094)
1995
21
Necrotizing Sialometaplasia after Silastic Ring Vertical Gastroplasty: Case Report and Review of Literature. (10733808)
1995
22
Necrotizing sialometaplasia. (8084644)
1994
23
Necrotizing sialometaplasia. (1543340)
1992
24
Necrotizing sialometaplasia in a patient with sickle-cell anemia. (2056377)
1991
25
Necrotizing sialometaplasia in the mouth floor secondary to reconstructive surgery for tongue carcinoma. (1776469)
1991
26
Necrotizing sialometaplasia masquerading as residual cancer of the lip. (3178123)
1988
27
Necrotizing sialometaplasia of major salivary glands. (3668381)
1987
28
Necrotizing sialometaplasia--a malignancy simulating oral lesion. (3458319)
1986
29
Necrotizing sialometaplasia of palatal minor salivary glands: a report on 2 cases. (3855981)
1985
30
Necrotizing sialometaplasia. Case report. (3864410)
1985
31
Case of the month. Necrotizing sialometaplasia. (6592257)
1984
32
Necrotizing sialometaplasia in the setting of acute and chronic sinusitis. (7346696)
1981
33
Warthin tumor exhibiting sebaceous differentiation and necrotizing sialometaplasia. (7281493)
1981
34
Necrotizing sialometaplasia. (6951608)
1980
35
Necrotizing sialometaplasia of the lip simulating squamous cell carcinoma. (7353814)
1980
36
Necrotizing sialometaplasia: review of the literature and report of nonulcerative case. (286778)
1979
37
Necrotizing sialometaplasia. (285245)
1979
38
Necrotizing sialometaplasia: a result of ischemia? Report of two cases and review of the literature. (298661)
1979
39
Necrotizing sialometaplasia affecting the minor labial glands. (284279)
1979
40
Necrotizing sialometaplasia of the nasopharynx. (464526)
1979
41
Necrotizing sialometaplasia. A condition simulating malignancy. (434849)
1979
42
Necrotizing sialometaplasia involving the nasal cavity. (839936)
1977
43
Necrotizing sialometaplasia: a source of confusion with carcinoma of the palate. (851091)
1977
44
Necrotizing sialometaplasia. (1075246)
1976
45
Necrotizing sialometaplasia of the palate. Ulcerative or necrotizing stage of leukokeratosis nicotina palati? (826493)
1976
46
Necrotizing sialometaplasia. (1065844)
1976
47
Necrotizing sialometaplasia. Report of a case. (1164230)
1975
48
Necrotizing sialometaplasia of parotid. (1184074)
1975
49
Necrotizing sialometaplasia. Pathologic quiz case 1. (1119996)
1975
50
Necrotizing sialometaplasia. A disease simulating malignancy. (4716764)
1973

Genetic Variations for Necrotizing Sialometaplasia

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Expression for genes affiliated with Necrotizing Sialometaplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Necrotizing Sialometaplasia

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Pathways for genes affiliated with Necrotizing Sialometaplasia

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.4TP53, MAML2

Compounds for genes affiliated with Necrotizing Sialometaplasia

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dutp449.2TP53, MKI67
2irinotecan44 49 1111.2TP53, MKI67
3mitomycin c449.1TP53, MKI67
4cyclophosphamide44 49 1111.1TP53, MKI67
5vincristine44 49 1111.0MKI67, TP53
6thymidylate448.8TP53, MKI67

GO Terms for genes affiliated with Necrotizing Sialometaplasia

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16Gene Ontology
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Biological processes related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:0459448.8TP53, MAML2, CRTC1

Products for genes affiliated with Necrotizing Sialometaplasia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Necrotizing Sialometaplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet