MCID: NCR003
MIFTS: 32

Necrotizing Sialometaplasia malady

Summaries for Necrotizing Sialometaplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Necrotizing sialometaplasia (also spelled necrotising sialometaplasia) is a benign ulcerative lesion... more...

MalaCards: Necrotizing Sialometaplasia, also known as sialometaplasia, necrotizing, is related to squamous cell carcinoma and sickle cell anemia. An important gene associated with Necrotizing Sialometaplasia is TP53 (tumor protein p53), and among its related pathways is Notch signaling pathway. The compounds dutp and irinotecan have been mentioned in the context of this disorder. Affiliated tissues include salivary gland, t cells and tongue.

Aliases & Classifications for Necrotizing Sialometaplasia

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8Disease Ontology, 10DISEASES, 60UMLS, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

necrotizing sialometaplasia 8 10
sialometaplasia, necrotizing 60


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Disease Ontology8 DOID:12901
SNOMED-CT56 109769000
MeSH34 D012797

Related Diseases for Necrotizing Sialometaplasia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Necrotizing Sialometaplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1squamous cell carcinoma10.4
2sickle cell anemia10.1
3tracheitis10.1
4maxillary sinus squamous cell carcinoma10.1
5sialadenitis10.1
6adenoid cystic carcinoma10.1
7adenosquamous carcinoma10.1
8adenoiditis10.1
9adenocarcinoma10.1
10eating disorder10.1
11esophagus adenocarcinoma10.1
12ischemia10.1
13lip cancer10.1
14actinic keratosis10.0TP53
15esophageal cancer10.0TP53
16benign meningioma10.0MKI67
17keratoacanthoma10.0MKI67
18smooth muscle tumor10.0MKI67
19ductal carcinoma in situ10.0TP53
20leukoplakia10.0MKI67
21cervical squamous cell carcinoma10.0MKI67
22leiomyosarcoma10.0TP53
23ependymoma10.0MKI67
24cervical intraepithelial neoplasia10.0MKI67
25gastrointestinal stromal tumor10.0MKI67
26kidney cancer10.0TP53
27bladder transitional cell carcinoma10.0TP53, MKI67
28breast cancer, invasive ductal10.0TP53, MKI67
29barrett's esophagus10.0MKI67, TP53
30adrenocortical carcinoma10.0MKI67, TP53
31leukemia10.0TP53
32bladder carcinoma10.0MKI67, TP53
33anaplastic astrocytoma10.0TP53, MKI67
34basal cell carcinoma10.0MKI67, TP53
35transitional cell carcinoma10.0MKI67, TP53
36lacrimal gland cancer10.0CRTC1, MAML2
37cutaneous mucoepidermoid carcinoma10.0MAML2, CRTC1
38lipoadenoma10.0MAML2, CRTC1
39cervical adenosquamous carcinoma10.0CRTC1, MAML2
40epithelial-myoepithelial carcinoma10.0MAML2, CRTC1
41hidradenoma10.0MAML2, CRTC1
42oligodendroglioma10.0TP53, MKI67
43b-cell lymphomas10.0MKI67, TP53
44mucoepidermoid carcinoma10.0MAML2, MKI67, CRTC1

Graphical network of the top 20 diseases related to Necrotizing Sialometaplasia:



Diseases related to necrotizing sialometaplasia

Clinical Features for Necrotizing Sialometaplasia

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Drugs & Therapeutics for Necrotizing Sialometaplasia

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Necrotizing Sialometaplasia

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Genetic Tests for Necrotizing Sialometaplasia

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Anatomical Context for Necrotizing Sialometaplasia

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32MalaCards
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MalaCards organs/tissues related to Necrotizing Sialometaplasia:

32
Salivary gland, T cells, Tongue, Trachea, Breast, Testes

Animal Models for Necrotizing Sialometaplasia or affiliated genes

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Publications for Necrotizing Sialometaplasia

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50PubMed
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Articles related to Necrotizing Sialometaplasia:

(show top 50)    (show all 141)
idTitleAuthorsYear
1
Oral and maxillofacial pathology. Case of the month. Diagnosis: Necrotizing sialometaplasia. (23930450)
2013
2
CT findings of necrotizing sialometaplasia. (22074871)
2012
3
Necrotizing sialometaplasia of the parotid gland in a dog. (21088187)
2010
4
Necrotizing sialometaplasia in a patient who is HIV positive: a case report. (20618783)
2010
5
Necrotizing sialometaplasia of bronchial mucosa. (19948640)
2010
6
A clinical case of necrotizing sialometaplasia and conjunctival hemorrhage. (20842082)
2010
7
Necrotizing sialometaplasia: a practical approach to the diagnosis. (19415943)
2009
8
Necrotizing sialometaplasia of the palate in a cocaine-using patient. A case report. (18427364)
2008
9
Necrotizing sialometaplasia: an important diagnosis--review of the literature and spectrum of clinical presentation. (15789986)
2005
10
Necrotizing sialometaplasia: a case report. (15503360)
2004
11
A case of necrotizing sialometaplasia in the upper lip. (12970596)
2003
12
Necrotizing sialometaplasia. (12955830)
2003
13
Oral pathology quiz #35. Case number 2. Necrotizing sialometaplasia. (16795953)
2002
14
Necrotizing sialometaplasia: a potential diagnostic pitfall. (11952867)
2002
15
First case of full-thickness palatal necrotizing sialometaplasia. (11893268)
2002
16
Oral pathology. Fall 1998 case of the month. Necrotizing sialometaplasia. (10596625)
1998
17
Necrotizing sialometaplasia: literature review and case reports. (8754467)
1996
18
Necrotizing sialometaplasia of the larynx. (8607453)
1996
19
Necrotizing sialometaplasia coincident with ipsilateral infarcted antral polyps. (8645669)
1996
20
Necrotizing sialometaplasia: a case report. (7875358)
1994
21
Necrotizing squamous metaplasia in herpetic tracheitis following prolonged intubation: a lesion similar to necrotizing sialometaplasia. (8388361)
1993
22
Necrotizing sialometaplasia (adenometaplasia) of the trachea. (1398527)
1992
23
Necrotizing sialometaplasia. (1624902)
1992
24
Necrotizing sialometaplasia: report of 12 new cases. (2248941)
1990
25
Necrotizing sialometaplasia: review of 127 cases. (2699611)
1989
26
Necrotizing sialometaplasia occurring during pregnancy: report of a case. (3165123)
1988
27
Necrotizing sialometaplasia. (3345688)
1988
28
Posttraumatic lobular squamous metaplasia of breast. An unusual pseudocarcinomatous metaplasia resembling squamous (necrotizing) sialometaplasia of the salivary gland. (3237714)
1988
29
Necrotizing sialometaplasia: report of two cases. (3473698)
1987
30
Necrotizing sialometaplasia of the nasal cavity. (3083385)
1986
31
Necrotizing sialometaplasia obscuring an underlying malignancy: report of a case. (3459842)
1986
32
Necrotizing sialometaplasia: a sheep in wolf's clothing. Healing as a diagnostic test. (3947128)
1986
33
Necrotizing sialometaplasia. (3869291)
1985
34
Necrotizing sialometaplasia: frequency of histologic misdiagnosis. (6582439)
1984
35
Necrotizing sialometaplasia: report of five cases. (6836063)
1983
36
Necrotizing sialometaplasia of the larynx secondary to atheromatous embolization. (7064921)
1982
37
Necrotizing sialometaplasia. (7242209)
1981
38
Necrotizing sialometaplasia--a lesion of minor salivary glands that mimics malignancies. (7337385)
1981
39
Bilateral necrotizing sialometaplasia: a case report. (6942128)
1981
40
Necrotizing sialometaplasia: report of an ulcerative case. (6942043)
1981
41
Necrotizing sialometaplasia of the bucca. (7315317)
1981
42
Necrotizing sialometaplasia of the palate and adenocarcinoma of the esophagus. (7389596)
1980
43
Case for diagnosis. Necrotizing sialometaplasia, left hard palate. (113695)
1979
44
Necrotizing sialometaplasia of palate. (454999)
1979
45
Necrotizing sialometaplasia. A self-limited pseudotumoral palatal ulcer. (655582)
1978
46
Necrotizing sialometaplasia. (103857)
1978
47
NECROTIZING SIALOMETAPLASIA. (269338)
1977
48
A patient with necrotizing sialometaplasia. (412803)
1977
49
Necrotizing sialometaplasia: report of three cases. (1066463)
1976
50
Necrotizing sialometaplasia. Report of five additional cases. (4524380)
1974

Genetic Variations for Necrotizing Sialometaplasia

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Expression for genes affiliated with Necrotizing Sialometaplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Necrotizing Sialometaplasia

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Pathways for genes affiliated with Necrotizing Sialometaplasia

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29KEGG, 37NCBI BioSystems Database
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Pathways related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.4TP53, MAML2

Compounds for genes affiliated with Necrotizing Sialometaplasia

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dutp449.2TP53, MKI67
2irinotecan44 49 1111.2TP53, MKI67
3mitomycin c449.1TP53, MKI67
4cyclophosphamide44 49 1111.1TP53, MKI67
5vincristine44 49 1111.0MKI67, TP53
6thymidylate448.8TP53, MKI67

GO Terms for genes affiliated with Necrotizing Sialometaplasia

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16Gene Ontology
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Biological processes related to Necrotizing Sialometaplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoterGO:0459448.8TP53, MAML2, CRTC1

Products for genes affiliated with Necrotizing Sialometaplasia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Necrotizing Sialometaplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet