MCID: NCR014
MIFTS: 22

Necrotizing Soft Tissue Infection

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Necrotizing Soft Tissue Infection

MalaCards integrated aliases for Necrotizing Soft Tissue Infection:

Name: Necrotizing Soft Tissue Infection 55

Characteristics:

Orphanet epidemiological data:

55
necrotizing soft tissue infection
Inheritance: Not applicable;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Orphanet 55 ORPHA440368
ICD10 via Orphanet 33 M72.6

Summaries for Necrotizing Soft Tissue Infection

MalaCards based summary : Necrotizing Soft Tissue Infection is related to gallbladder disease 1 and mycobacterium marinum. An important gene associated with Necrotizing Soft Tissue Infection is FCN2 (Ficolin 2). The drugs Rho(D) Immune Globulin and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include skin, appendix and breast.

Related Diseases for Necrotizing Soft Tissue Infection

Diseases related to Necrotizing Soft Tissue Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 gallbladder disease 1 9.8
2 mycobacterium marinum 9.8
3 neutrophilic dermatosis, acute febrile 9.8
4 streptococcal group a invasive disease 9.8
5 episodic pain syndrome, familial, 1 9.8
6 streptococcal toxic-shock syndrome 9.8
7 burns 9.8
8 neutropenia 9.8
9 spinal cord injury 9.8
10 osteomyelitis 9.8
11 paronychia 9.8
12 toxic shock syndrome 9.8
13 ascending colon cancer 9.8
14 acute pancreatitis 9.8
15 pancreatitis 9.8
16 decubitus ulcer 9.8
17 epiglottitis 9.8
18 cyclic neutropenia 9.8
19 fasciitis 9.8
20 gorlin-chaudhry-moss syndrome 9.8
21 candida glabrata 9.8

Graphical network of the top 20 diseases related to Necrotizing Soft Tissue Infection:



Diseases related to Necrotizing Soft Tissue Infection

Symptoms & Phenotypes for Necrotizing Soft Tissue Infection

Drugs & Therapeutics for Necrotizing Soft Tissue Infection

Drugs for Necrotizing Soft Tissue Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Rho(D) Immune Globulin Phase 2
2 gamma-Globulins Phase 2
3 Immunoglobulins Phase 2
4 Immunoglobulins, Intravenous Phase 2
5 Antibodies Phase 2
6
Glycerol Approved, Investigational 56-81-5 753
7
Daptomycin Approved, Investigational 103060-53-3 16129629
8
Protein C Approved
9 Protective Agents
10 Anti-Bacterial Agents
11 Anti-Infective Agents

Interventional clinical trials:

(show all 14)

# Name Status NCT ID Phase Drugs
1 Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections Recruiting NCT02469857 Phase 3 AB103 0.5 mg/kg
2 Evaluation of Safety, PK and Immunomodulatory Effects of AB103 in Necrotizing Soft Tissue Infections Patients Completed NCT01417780 Phase 2 AB103 0.25 mg/kg;AB103 0.5 mg/kg;NaCl 0.9%
3 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
4 Negative Pressure Wound Therapy and Allogeneic Human Skin Grafts for Wound Bed Preparation Unknown status NCT02314468
5 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
6 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
7 Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections Completed NCT00261807 Daptomycin 6mg/kg/day
8 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352
9 RNAseq Analysis of Microbial Gene Expression in Necrotizing Soft Tissue Infections Recruiting NCT02025816
10 Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs). Recruiting NCT01790698
11 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
12 Effects of Repetitive Hyperbaric Oxygen Therapy in Patients With Acute Ischaemic Stroke Recruiting NCT03431402 Hyperbaric oxygen
13 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650
14 Hyperglycemia in Surgical Infections Terminated NCT00353275 Strict Glycemic control;Conventional Glycemic Control

Search NIH Clinical Center for Necrotizing Soft Tissue Infection

Genetic Tests for Necrotizing Soft Tissue Infection

Anatomical Context for Necrotizing Soft Tissue Infection

MalaCards organs/tissues related to Necrotizing Soft Tissue Infection:

38
Skin, Appendix, Breast, Liver, Colon, Spinal Cord

Publications for Necrotizing Soft Tissue Infection

Articles related to Necrotizing Soft Tissue Infection:

(show all 45)
# Title Authors Year
1
Open-to-Air Is a Viable Option for Initial Wound Care in Necrotizing Soft Tissue Infection that Allows Early Detection of Recurrence without Need for Painful Dressing Changes or Return to Operating Room. ( 29211657 )
2018
2
Necrotizing soft tissue infection following femoral venous catheter infection. ( 29387911 )
2018
3
Ureaplasma urealyticum necrotizing soft tissue infection. ( 28803865 )
2017
4
Fistulating Richter's Hernia of Groin with Necrotizing Soft Tissue Infection: A Lethal Combination. ( 28892969 )
2017
5
Necrotizing soft tissue infection: clinical characteristics and outcomes at a reconstructive center in Jilin Province. ( 29281989 )
2017
6
A Woman with a Necrotizing Soft-Tissue Infection. ( 29190840 )
2017
7
Necrotizing soft tissue infection of the thigh associated with retroperitoneal abscess in a patient with locally advanced ascending colon cancer: A case report. ( 29124012 )
2017
8
Retroperitoneal Necrotizing Soft Tissue Infection in a Healthy Adult Masquerading as Acute Pancreatitis. ( 28188947 )
2017
9
Necrotizing Soft Tissue Infection or Sweet Syndrome: Surgery Versus No Surgery?: A Case Report. ( 28151765 )
2017
10
Calculated decisions: LRINEC Score for necrotizing soft-tissue infection ( 29068632 )
2017
11
The Lectin Complement Pathway in Patients with Necrotizing Soft Tissue Infection. ( 27355483 )
2016
12
Failure to decolonize mupirocin and linezolid resistant MRSA from a patient with necrotizing soft tissue infection. ( 26837722 )
2016
13
Successful treatment of a rare extended retroperitoneal necrotizing soft tissue infection caused by extended-spectrum beta-lactamase-producing Escherichia coli: A case report. ( 27930570 )
2016
14
Necrotizing soft tissue infection: analysis of the factors related to mortality in 30 cases of a single institution for 5 years. ( 27433464 )
2016
15
Pentraxin-3 to better delineate necrotizing soft tissue infection: not really! ( 27311489 )
2016
16
Necrotizing Soft Tissue Infection Caused by Spilled Gallstones. ( 27144208 )
2016
17
Necrotizing soft tissue infection caused by Serratia marcescens: A case report and literature review. ( 26778253 )
2016
18
Necrotizing soft tissue infection following a peripheral bypass. ( 25733218 )
2015
19
Necrotizing Soft-Tissue Infection of the Thumb: A Case Report. ( 29252576 )
2015
20
Necrotizing soft tissue infection of the right anterolateral abdominal wall caused by a ruptured gangrenous appendix in an elderly diabetic patient. ( 26110301 )
2015
21
Cyclic neutropenia with a novel gene mutation presenting with a necrotizing soft tissue infection and severe sepsis: case report. ( 25880377 )
2015
22
Predictors of mortality in necrotizing soft tissue infection. ( 25264645 )
2014
23
Necrotizing soft-tissue infection: laboratory risk indicator for necrotizing soft tissue infections score. ( 24696561 )
2014
24
Streptococcal toxic shock syndrome from necrotizing soft-tissue infection of the breast caused by a mucoid type strain. ( 25260866 )
2014
25
Fatal Necrotizing Soft Tissue Infection by Aeromonas hydrophila. ( 24959446 )
2014
26
Necrotizing Soft Tissue Infection Occurring after Exposure to Mycobacterium marinum. ( 25506004 )
2014
27
Necrotizing soft-tissue infection in an adult. ( 24642044 )
2014
28
Necrotizing soft tissue infection with gas formation caused by Vibrio vulnificus and misdiagnosed as Pseudomonas aeruginosa. ( 23158593 )
2013
29
Vulvar necrotizing soft tissue infection: A review of a multi-disciplinary surgical emergency and management in the modern era. ( 24371682 )
2013
30
A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft-tissue infection induced by Streptococcus pyogenes. ( 23493729 )
2013
31
Timing of redAcbridement after initial source control impacts survival in necrotizing soft tissue infection. ( 24160803 )
2013
32
Use of Methylnaltrexone to Induce Laxation in Acutely Injured Patients With Burns and Necrotizing Soft-Tissue Infections. ( 23877147 )
2013
33
A case of Apophysomyces trapeziformis necrotizing soft tissue infection. ( 23891642 )
2013
34
Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes. ( 23163625 )
2013
35
Development and validation of a necrotizing soft-tissue infection mortality risk calculator using NSQIP. ( 23628224 )
2013
36
Klebsiella necrotizing soft tissue infections in liver transplant recipients: a case series. ( 23782431 )
2013
37
Immunocompromised status in patients with necrotizing soft-tissue infection. ( 23677405 )
2013
38
Severe monobacterial necrotizing soft tissue infection by group A Streptococcus: A surgical emergency. ( 23569908 )
2012
39
Necrotizing soft tissue infection of the scalp after fronto-facial advancement by internal distraction in a 7-year old girl with Gorlin-Chaudhry-Moss syndrome--a case report. ( 21216154 )
2011
40
Can paronychia cause a remote necrotizing soft tissue infection? ( 18296013 )
2011
41
Case Report: Injectable pentazocine abuse leading to necrotizing soft tissue infection and florid osteomyelitis. ( 23204978 )
2011
42
Necrotizing soft-tissue infection caused by both Candida glabrata and Streptococcus agalactiae. ( 19153361 )
2009
43
Fulminant epiglottitis with evolution to necrotizing soft tissue infections and fasciitis due to Aeromonas hydrophila. ( 18165860 )
2008
44
Necrotizing soft tissue infections of the extremities and back. ( 16672902 )
2006
45
Necrotizing soft tissue infection from decubitus ulcer after spinal cord injury. ( 15083007 )
2004

Variations for Necrotizing Soft Tissue Infection

Expression for Necrotizing Soft Tissue Infection

Search GEO for disease gene expression data for Necrotizing Soft Tissue Infection.

Pathways for Necrotizing Soft Tissue Infection

GO Terms for Necrotizing Soft Tissue Infection

Sources for Necrotizing Soft Tissue Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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