MCID: NCR014
MIFTS: 19

Necrotizing Soft Tissue Infection

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Necrotizing Soft Tissue Infection

MalaCards integrated aliases for Necrotizing Soft Tissue Infection:

Name: Necrotizing Soft Tissue Infection 56

Characteristics:

Orphanet epidemiological data:

56
necrotizing soft tissue infection
Inheritance: Not applicable;

Classifications:

Orphanet: 56  
Rare infectious diseases


External Ids:

Orphanet 56 ORPHA440368
ICD10 via Orphanet 34 M72.6

Summaries for Necrotizing Soft Tissue Infection

MalaCards based summary : Necrotizing Soft Tissue Infection is related to gorlin-chaudhry-moss syndrome and burns. The drugs Rho(D) Immune Globulin and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and appendix.

Related Diseases for Necrotizing Soft Tissue Infection

Diseases related to Necrotizing Soft Tissue Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
id Related Disease Score Top Affiliating Genes
1 gorlin-chaudhry-moss syndrome 9.7
2 burns 9.7
3 neutropenia 9.7
4 spinal cord injury 9.7
5 osteomyelitis 9.7
6 paronychia 9.7
7 toxic shock syndrome 9.7
8 acute pancreatitis 9.7
9 pancreatitis 9.7
10 decubitus ulcer 9.7
11 epiglottitis 9.7
12 fasciitis 9.7
13 candida glabrata 9.7
14 mycobacterium marinum 9.7
15 streptococcal toxic-shock syndrome 9.7

Graphical network of the top 20 diseases related to Necrotizing Soft Tissue Infection:



Diseases related to Necrotizing Soft Tissue Infection

Symptoms & Phenotypes for Necrotizing Soft Tissue Infection

Drugs & Therapeutics for Necrotizing Soft Tissue Infection

Drugs for Necrotizing Soft Tissue Infection (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Rho(D) Immune Globulin Phase 2
2 gamma-Globulins Phase 2
3 Immunoglobulins Phase 2
4 Immunoglobulins, Intravenous Phase 2
5 Antibodies Phase 2
6
Glycerol Approved, Investigational 56-81-5 753
7
Daptomycin Approved, Investigational 103060-53-3 16129629
8
Protein C Approved
9 Protective Agents
10 methicillin
11 Anti-Bacterial Agents
12 Anti-Infective Agents

Interventional clinical trials:

(show all 16)

id Name Status NCT ID Phase Drugs
1 Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections Recruiting NCT02469857 Phase 3 AB103 0.5 mg/kg
2 Evaluation of Safety, PK and Immunomodulatory Effects of AB103 in Necrotizing Soft Tissue Infections Patients Completed NCT01417780 Phase 2 AB103 0.25 mg/kg;AB103 0.5 mg/kg;NaCl 0.9%
3 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
4 Soft Tissue Ultrasound of Infections Completed NCT01557426 Phase 1
5 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
6 Negative Pressure Wound Therapy and Allogeneic Human Skin Grafts for Wound Bed Preparation Unknown status NCT02314468
7 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
8 Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections Completed NCT00261807 Daptomycin 6mg/kg/day
9 Panton Valentine Leucocidin Completed NCT02798497
10 Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus Completed NCT01141101
11 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352
12 RNAseq Analysis of Microbial Gene Expression in Necrotizing Soft Tissue Infections Recruiting NCT02025816
13 Systems Medicine to Study Necrotizing Soft Tissue Infections (NSTIs). Recruiting NCT01790698
14 Severe Soft Tissue Infections: Perspectives of Patients and Significant Others Recruiting NCT02169128
15 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650
16 Hyperglycemia in Surgical Infections Terminated NCT00353275 Strict Glycemic control;Conventional Glycemic Control

Search NIH Clinical Center for Necrotizing Soft Tissue Infection

Genetic Tests for Necrotizing Soft Tissue Infection

Anatomical Context for Necrotizing Soft Tissue Infection

MalaCards organs/tissues related to Necrotizing Soft Tissue Infection:

39
Skin, Colon, Appendix, Liver, Spinal Cord, Breast

Publications for Necrotizing Soft Tissue Infection

Articles related to Necrotizing Soft Tissue Infection:

(show all 38)
id Title Authors Year
1
Fistulating Richter's Hernia of Groin with Necrotizing Soft Tissue Infection: A Lethal Combination. ( 28892969 )
2017
2
Ureaplasma urealyticum necrotizing soft tissue infection. ( 28803865 )
2017
3
Necrotizing Soft Tissue Infection or Sweet Syndrome: Surgery Versus No Surgery?: A Case Report. ( 28151765 )
2017
4
Retroperitoneal Necrotizing Soft Tissue Infection in a Healthy Adult Masquerading as Acute Pancreatitis. ( 28188947 )
2017
5
Necrotizing Soft Tissue Infection Caused by Spilled Gallstones. ( 27144208 )
2016
6
The Lectin Complement Pathway in Patients with Necrotizing Soft Tissue Infection. ( 27355483 )
2016
7
Pentraxin-3 to better delineate necrotizing soft tissue infection: not really! ( 27311489 )
2016
8
Necrotizing soft tissue infection: analysis of the factors related to mortality in 30 cases of a single institution for 5 years. ( 27433464 )
2016
9
Necrotizing soft tissue infection caused by Serratia marcescens: A case report and literature review. ( 26778253 )
2016
10
Successful treatment of a rare extended retroperitoneal necrotizing soft tissue infection caused by extended-spectrum beta-lactamase-producing Escherichia coli: A case report. ( 27930570 )
2016
11
Failure to decolonize mupirocin and linezolid resistant MRSA from a patient with necrotizing soft tissue infection. ( 26837722 )
2016
12
Necrotizing soft tissue infection following a peripheral bypass. ( 25733218 )
2015
13
Necrotizing soft tissue infection of the right anterolateral abdominal wall caused by a ruptured gangrenous appendix in an elderly diabetic patient. ( 26110301 )
2015
14
Cyclic neutropenia with a novel gene mutation presenting with a necrotizing soft tissue infection and severe sepsis: case report. ( 25880377 )
2015
15
Necrotizing soft-tissue infection in an adult. ( 24642044 )
2014
16
Necrotizing soft-tissue infection: laboratory risk indicator for necrotizing soft tissue infections score. ( 24696561 )
2014
17
Fatal Necrotizing Soft Tissue Infection by Aeromonas hydrophila. ( 24959446 )
2014
18
Necrotizing Soft Tissue Infection Occurring after Exposure to Mycobacterium marinum. ( 25506004 )
2014
19
Predictors of mortality in necrotizing soft tissue infection. ( 25264645 )
2014
20
Streptococcal toxic shock syndrome from necrotizing soft-tissue infection of the breast caused by a mucoid type strain. ( 25260866 )
2014
21
A case of Apophysomyces trapeziformis necrotizing soft tissue infection. ( 23891642 )
2013
22
Immunocompromised status in patients with necrotizing soft-tissue infection. ( 23677405 )
2013
23
Use of Methylnaltrexone to Induce Laxation in Acutely Injured Patients With Burns and Necrotizing Soft-Tissue Infections. ( 23877147 )
2013
24
Vulvar necrotizing soft tissue infection: A review of a multi-disciplinary surgical emergency and management in the modern era. ( 24371682 )
2013
25
Necrotizing soft tissue infection with gas formation caused by Vibrio vulnificus and misdiagnosed as Pseudomonas aeruginosa. ( 23158593 )
2013
26
A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft-tissue infection induced by Streptococcus pyogenes. ( 23493729 )
2013
27
Timing of redAcbridement after initial source control impacts survival in necrotizing soft tissue infection. ( 24160803 )
2013
28
Oxygen free radical and antioxidant status in necrotizing soft tissue infection of the lower extremity; a report of two cases with opposite outcomes. ( 23163625 )
2013
29
Development and validation of a necrotizing soft-tissue infection mortality risk calculator using NSQIP. ( 23628224 )
2013
30
Klebsiella necrotizing soft tissue infections in liver transplant recipients: a case series. ( 23782431 )
2013
31
Severe monobacterial necrotizing soft tissue infection by group A Streptococcus: A surgical emergency. ( 23569908 )
2012
32
Necrotizing soft tissue infection of the scalp after fronto-facial advancement by internal distraction in a 7-year old girl with Gorlin-Chaudhry-Moss syndrome--a case report. ( 21216154 )
2011
33
Can paronychia cause a remote necrotizing soft tissue infection? ( 18296013 )
2011
34
Case Report: Injectable pentazocine abuse leading to necrotizing soft tissue infection and florid osteomyelitis. ( 23204978 )
2011
35
Necrotizing soft-tissue infection caused by both Candida glabrata and Streptococcus agalactiae. ( 19153361 )
2009
36
Fulminant epiglottitis with evolution to necrotizing soft tissue infections and fasciitis due to Aeromonas hydrophila. ( 18165860 )
2008
37
Necrotizing soft tissue infections of the extremities and back. ( 16672902 )
2006
38
Necrotizing soft tissue infection from decubitus ulcer after spinal cord injury. ( 15083007 )
2004

Variations for Necrotizing Soft Tissue Infection

Expression for Necrotizing Soft Tissue Infection

Search GEO for disease gene expression data for Necrotizing Soft Tissue Infection.

Pathways for Necrotizing Soft Tissue Infection

GO Terms for Necrotizing Soft Tissue Infection

Sources for Necrotizing Soft Tissue Infection

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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