MCID: NCR001
MIFTS: 38

Necrotizing Ulcerative Gingivitis

Categories: Rare diseases, Oral diseases

Aliases & Classifications for Necrotizing Ulcerative Gingivitis

MalaCards integrated aliases for Necrotizing Ulcerative Gingivitis:

Name: Necrotizing Ulcerative Gingivitis 12 14 69
Acute Necrotizing Ulcerative Gingivitis 12 50
Vincent's Disease 12 69
Vincent Angina 12 69
Anug 12 50
Acute Necrotising Ulcerative Gingivostomatitis [ambiguous] 12
Acute Necrotising Ulcerative Gingivitis [ambiguous] 12
Acute Necrotising Ulcerative Gingivostomatitis 12
Acute Necrotizing Ulcerative Gingivostomatitis 12
Acute Necrotising Ulcerative Gingivitis 12
Early Acute Necrotising Gingivitis 12
Gingivitis, Necrotizing Ulcerative 42
Acute Ulceromembranous Gingivitis 12
Vincent's Angina - Pharyngitis 12
Vincent's Infection, Any Site 12
Acute Membranous Gingivitis 50
Fusospirillary Gingivitis 50
Phagedenic Gingivitis 50
Vincent's Angina Nos 12
Vincent's Gingivitis 50
Vincent's Stomatitis 50
Vincent's Infection 50
Angina - Vincents 12
Vincent's Angina 12
Fusospirillosis 50
Trench Mouth 12

Classifications:



Summaries for Necrotizing Ulcerative Gingivitis

MalaCards based summary : Necrotizing Ulcerative Gingivitis, also known as acute necrotizing ulcerative gingivitis, is related to gingivitis and hypogonadotropic hypogonadism 16 with or without anosmia. An important gene associated with Necrotizing Ulcerative Gingivitis is GUSB (Glucuronidase Beta), and among its related pathways/superpathways are Staphylococcus aureus infection and B Cell Development Pathways. The drugs Folic Acid and Micronutrients have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are hematopoietic system and immune system

Wikipedia : 72 Acute necrotizing ulcerative gingivitis (ANUG; colloquially known as trench mouth) is a common,... more...

Related Diseases for Necrotizing Ulcerative Gingivitis

Diseases related to Necrotizing Ulcerative Gingivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Related Disease Score Top Affiliating Genes
1 gingivitis 10.7
2 hypogonadotropic hypogonadism 16 with or without anosmia 10.6 GLA GUSB
3 mucolipidosis ii alpha/beta 10.5 BSG GUSB
4 acquired polycythemia 10.5 CD40LG GUSB
5 shigellosis 10.4 CD40LG GUSB
6 periodontitis 10.2
7 milk allergy 10.2 CD40LG IL18
8 multiple familial trichoepithelioma 10.1 CFB IL10
9 endosalpingiosis 10.1 CFB IL10
10 pulmonary tuberculosis 10.1 CD40LG CTRL
11 tick-borne encephalitis 10.1 CD40LG IL18
12 balkan hemorrhagic fever 10.0 CD40LG IL10
13 diabetic angiopathy 10.0 CD40LG IL10
14 dumping syndrome 10.0 CD40LG IL10
15 centronuclear myopathy 5 9.9 CD40LG IL10
16 extrapulmonary tuberculosis 9.9 CD40LG IL10
17 alkhurma hemorrhagic fever 9.9 CD40LG IL10
18 reproductive system disease 9.9 CD40LG IL10
19 tularemia 9.9 CD40LG IL10
20 hepadnavirus infection 9.9 CD40LG IL10
21 cryptococcosis 9.9 CD40LG IL10
22 megaloblastic anemia 9.9 CD40LG IL10
23 conduct disorder 9.9 CD40LG IL10
24 leukemia 9.9
25 bartonellosis 9.9 CD40LG IL10
26 glioblastoma multiforme 9.9 CD40LG IL10
27 ostertagiasis 9.9 CD40LG IL10
28 plummer's disease 9.9 CD40LG IL10
29 residual stage corticosteroid-induced glaucoma 9.9 CD40LG IL10
30 disease of mental health 9.8 CD40LG IL10
31 crustacean allergy 9.8 IL10 IL18
32 motor peripheral neuropathy 9.8 CD40LG IL10
33 ovarian endometrioid cystadenoma 9.8 CD40LG IL10
34 extrahepatic bile duct adenocarcinoma 9.8 CD40LG IL10
35 vascular dementia 9.8 IL10 IL18
36 iida kannari syndrome 9.8 CD40LG IL10
37 atrophy of prostate 9.8 CD40LG IL10
38 acute monoblastic leukemia 9.8 IL10 IL18
39 sublingual gland cancer 9.8 CD40LG IL10
40 progressive relapsing multiple sclerosis 9.8 CD40LG IL10
41 von willebrand's disease 9.7
42 bruxism 9.7
43 lupus erythematosus 9.7
44 stomatitis 9.7
45 noma 9.7
46 systemic lupus erythematosus 9.7
47 bacteremia 9.7
48 drug addiction 9.7
49 acute lymphocytic leukemia 9.7
50 pelvic varices 9.7 CD40LG IL10

Graphical network of the top 20 diseases related to Necrotizing Ulcerative Gingivitis:



Diseases related to Necrotizing Ulcerative Gingivitis

Symptoms & Phenotypes for Necrotizing Ulcerative Gingivitis

MGI Mouse Phenotypes related to Necrotizing Ulcerative Gingivitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 BSG CD40LG CFB GUSB IL10 IL18
2 immune system MP:0005387 9.17 BSG CD40LG CFB GLA IL10 IL18

Drugs & Therapeutics for Necrotizing Ulcerative Gingivitis

Drugs for Necrotizing Ulcerative Gingivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
2 Micronutrients Phase 2
3 Trace Elements Phase 2
4 Vitamin B Complex Phase 2
5 Vitamins Phase 2
6 Folate Nutraceutical Phase 2
7
Pantothenic acid Nutraceutical, Vet_approved Phase 2 79-83-4 988 6613
8 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Dexpanthenol Mouthwash to Treat Oral Mucositis Unknown status NCT01318889 Phase 2 Dexpanthenol

Search NIH Clinical Center for Necrotizing Ulcerative Gingivitis

Cochrane evidence based reviews: gingivitis, necrotizing ulcerative

Genetic Tests for Necrotizing Ulcerative Gingivitis

Anatomical Context for Necrotizing Ulcerative Gingivitis

MalaCards organs/tissues related to Necrotizing Ulcerative Gingivitis:

39
Bone

Publications for Necrotizing Ulcerative Gingivitis

Articles related to Necrotizing Ulcerative Gingivitis:

(show top 50) (show all 103)
id Title Authors Year
1
Unexpected Acute Necrotizing Ulcerative Gingivitis in a Well-controlled HIV-infected Case. ( 28781315 )
2017
2
Prevalence and treatment of necrotizing ulcerative gingivitis (NUG) in the British Armed Forces: a case-control study. ( 27830369 )
2016
3
Complete Genome Sequence for Treponema sp. OMZ 838 (ATCC 700772, DSM 16789), Isolated from a Necrotizing Ulcerative Gingivitis Lesion. ( 25540346 )
2014
4
Managing patients with necrotizing ulcerative gingivitis. ( 23763733 )
2013
5
Necrotizing ulcerative gingivitis and the orthodontic patient: a case series. ( 23524550 )
2013
6
The phylum Synergistetes in gingivitis and necrotizing ulcerative gingivitis. ( 22878253 )
2012
7
Prevalence of necrotizing ulcerative gingivitis and associated factors in Koranic boarding schools in Senegal. ( 22779382 )
2012
8
Necrotizing ulcerative gingivitis: a discussion of four dissimilar presentations. ( 22206178 )
2011
9
Images in emergency medicine. Acute necrotizing ulcerative gingivitis. ( 16492485 )
2006
10
Inflammatory cytokine profile and circulating cortisol levels in malnourished children with necrotizing ulcerative gingivitis. ( 16266866 )
2005
11
Acute necrotizing ulcerative gingivitis and bacteremia caused by Stenotrophomonas maltophilia in an immunocompromised host. ( 15702051 )
2005
12
The epidemiology, etiology, and pathophysiology of acute necrotizing ulcerative gingivitis associated with malnutrition. ( 15318254 )
2004
13
Gingival crevice microbiota from Chinese patients with gingivitis or necrotizing ulcerative gingivitis. ( 14871191 )
2004
14
Treponema putidum sp. nov., a medium-sized proteolytic spirochaete isolated from lesions of human periodontitis and acute necrotizing ulcerative gingivitis. ( 15280279 )
2004
15
Acute myelogenous leukemia complicated by acute necrotizing ulcerative gingivitis due to Aspergillus terreus. ( 12769350 )
2003
16
Oral pemphigoid masquerading as necrotizing ulcerative gingivitis in a child. ( 12083540 )
2002
17
Treponema parvum sp. nov., a small, glucoronic or galacturonic acid-dependent oral spirochaete from lesions of human periodontitis and acute necrotizing ulcerative gingivitis. ( 11411720 )
2001
18
Necrotizing ulcerative gingivitis. ( 10863376 )
1999
19
Acute necrotizing ulcerative gingivitis-periodontitis: a literature review. ( 9597852 )
1998
20
Human Herpesviridae in acute necrotizing ulcerative gingivitis in children in Nigeria. ( 9467378 )
1997
21
Severity of necrotizing ulcerative gingivitis in Nigerian children. ( 9055679 )
1995
22
Necrotizing ulcerative gingivitis, periodontitis, and stomatitis: clinical staging and predisposing factors. ( 8558402 )
1995
23
Case #1. Acute necrotizing ulcerative gingivitis. ( 8619074 )
1995
24
Acute necrotizing ulcerative gingivitis: risk factors involving host defense mechanisms. ( 9673175 )
1994
25
Serum IgG and IgM levels to bacterial antigens in necrotizing ulcerative gingivitis. ( 8463942 )
1993
26
Oral hygiene status and necrotizing ulcerative gingivitis in Nigerian children. ( 8295093 )
1993
27
Acute necrotizing ulcerative gingivitis is associated with attachment loss. ( 1753002 )
1991
28
The treatment of acute necrotizing ulcerative gingivitis. ( 2068255 )
1991
29
Identification of spirochetes related to Treponema pallidum in necrotizing ulcerative gingivitis and chronic periodontitis. ( 1713299 )
1991
30
Pathogen-related spirochetes identified within gingival tissue from patients with acute necrotizing ulcerative gingivitis. ( 1855985 )
1991
31
The problem of the taxonomy of the fusiform bacillus of acute necrotizing ulcerative gingivitis (Vincent's gingivitis). ( 2196849 )
1990
32
Spirochetes in early lesions of necrotizing ulcerative gingivitis experimentally induced in beagles. ( 2087354 )
1990
33
Acute necrotizing ulcerative gingivitis associated with von Willebrand's disease: a case report. ( 2150929 )
1990
34
A case-control study of plasma ascorbate and acute necrotizing ulcerative gingivitis. ( 3163353 )
1988
35
Allelic variants for complement factors C3, C4, and B in acute necrotizing ulcerative gingivitis. ( 3163352 )
1988
36
Epidemiology of acute necrotizing ulcerative gingivitis. ( 3066627 )
1988
37
Acute necrotizing ulcerative gingivitis. A review of diagnosis, etiology and treatment. ( 3514841 )
1986
38
Peripheral blood phagocyte function in acute necrotizing ulcerative gingivitis. ( 2941561 )
1986
39
Acute necrotizing ulcerative gingivitis: etiology and stress relationships. ( 3462166 )
1986
40
Necrotizing ulcerative gingivitis in the military from ancient to modern times. ( 3935959 )
1985
41
ABC's periodontics. "N" is for necrotizing ulcerative gingivitis. ( 3866022 )
1985
42
Necrotizing ulcerative gingivitis in beagle dogs. III. Distribution of spirochetes in interdental gingival tissue. ( 2934537 )
1985
43
Acute necrotizing ulcerative gingivitis in a case of systemic lupus erythematosus. ( 3855317 )
1985
44
Necrotizing ulcerative gingivitis in beagle dogs. I. Attempts at unilateral induction and intraoral transmission of NUG, a microbiological and clinical study. ( 6232371 )
1984
45
Acute necrotizing ulcerative gingivitis: clinical features, etiology and treatment. ( 6585327 )
1984
46
Necrotizing ulcerative gingivitis in beagle dogs. II. Histologic characteristics of NUG in relation to interproximal contacts. ( 6232372 )
1984
47
Demographic and clinical data associated with acute necrotizing ulcerative gingivitis in a dental school population (ANUG-demographic and clinical data). ( 6592176 )
1984
48
Acute necrotizing ulcerative gingivitis: a review. ( 6594833 )
1984
49
Psychiatric, psychosocial, and endocrine correlates of acute necrotizing ulcerative gingivitis (trench mouth): a preliminary report. ( 6599850 )
1983
50
Leukocyte function in the etiology of acute necrotizing ulcerative gingivitis. ( 6577177 )
1983

Variations for Necrotizing Ulcerative Gingivitis

Expression for Necrotizing Ulcerative Gingivitis

Search GEO for disease gene expression data for Necrotizing Ulcerative Gingivitis.

Pathways for Necrotizing Ulcerative Gingivitis

Pathways related to Necrotizing Ulcerative Gingivitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.12 CFB IL10
2 11.05 CD40LG IL10
3 10.95 IL10 IL18
4 10.7 IL10 IL18
5 10.49 CD40LG IL10 IL18
6 10.36 CD40LG IL10 IL18

GO Terms for Necrotizing Ulcerative Gingivitis

Cellular components related to Necrotizing Ulcerative Gingivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CD40LG CFB GLA GUSB IL10 IL18
2 extracellular space GO:0005615 9.1 CD40LG CFB CTRL GUSB IL10 IL18

Biological processes related to Necrotizing Ulcerative Gingivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 B cell proliferation GO:0042100 9.16 CD40LG IL10
2 negative regulation of nitric oxide biosynthetic process GO:0045019 8.96 GLA IL10
3 type 2 immune response GO:0042092 8.62 IL10 IL18

Molecular functions related to Necrotizing Ulcerative Gingivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 CD40LG IL10 IL18
2 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 8.32 GLA

Sources for Necrotizing Ulcerative Gingivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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