Neonatal Alloimmune Thrombocytopenia malady

Wikipedia: Neonatal Alloimmune Thrombocytopenia (NAITP or NAIT or NAT for short; or fetal and neonatal alloimmune...⁴⁴ more...

MalaCards: Neonatal Alloimmune Thrombocytopenia, also known as thrombocytopenia, neonatal alloimmune, is related to heparin-induced thrombocytopenia and wiskott-aldrich syndrome. An important gene associated with Neonatal Alloimmune Thrombocytopenia is ITGA2 (integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)), and among its related pathways are Cell adhesion_Integrin inside-out signaling and Cell adhesion_Endothelial cell contacts by non-junctional mechanisms. The drugs interferon gamma-1b and danaparoid sodium and the compounds gr 144053 trihydrochloride and mns have been mentioned in the context of this disorder. Affiliated tissues include placenta and t cells.

neonatal alloimmune thrombocytopenia 7 33 43 thrombocytopenia, neonatal alloimmune 33

thrombocytopenia 43

Diseases related to neonatal alloimmune thrombocytopenia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 199)

id	Related Disease	Score	Top Affiliating Genes
1	heparin-induced thrombocytopenia	35.3	ITGA2, ITGA2B, ITGB3
2	wiskott-aldrich syndrome	31.2	ITGB3, ITGA2B, ITGA2
3	thrombocytopenia	30.3	POU2F3, HLA-DRB3, MMRN1, ITGB3, ITGB2, ITGA2B
4	thrombosis	29.4	POU2F3, MMRN1, ITGB3, ITGB2, ITGA2B, ITGA2
5	hepatitis c	28.9	HLA-DRB3, ITGB3, ITGA2B, ITGA2
6	hepatitis	28.9	HLA-DRB3, MMRN1, ITGB3, ITGB2, ITGA2B, ITGA2
7	von willebrand's disease	28.7	ITGA2, ITGA2B, ITGB3, MMRN1
8	lupus erythematosus	28.1	HLA-DRB3, ITGB3, ITGB2, ITGA2B, ITGA2
9	autoimmune thrombocytopenic purpura	27.8	ITGA2B, ITGB3
10	systemic lupus erythematosus	27.7	HLA-DRB3, ITGB3, ITGB2, ITGA2B, ITGA2
11	antiphospholipid syndrome	27.3	ITGA2, ITGA2B, ITGB3
12	purpura	26.3	POU2F3, HLA-DRB3, ITGB3, ITGB2, ITGA2B, ITGA2
13	hemorrhagic fever with renal syndrome	25.4	ITGB3, ITGA2B
14	bernard-soulier syndrome	25.2	ITGB3, ITGA2B, ITGA2
15	glanzmann's thrombasthenia	25.2	ITGA2, ITGA2B, ITGB3
16	thrombasthenia	25.2	ITGB3, ITGA2B, ITGA2
17	hypertrophic cardiomyopathy	24.9	ITGB3, ITGA2B, ITGA2
18	polycythemia vera	24.9	ITGA2, ITGB2, ITGB3, MMRN1
19	polycythemia	24.9	MMRN1, ITGB3, ITGB2, ITGA2
20	acute myocardial infarction	24.4	ITGB3, ITGB2, ITGA2B, ITGA2
21	nephropathy	24.1	ITGA2, ITGA2B, ITGB2, ITGB3
22	myocardial infarction	22.7	POU2F3, MMRN1, ITGB3, ITGB2, ITGA2B, ITGA2
23	coronary thrombosis	12.8	ITGB3, POU2F3
24	essential thrombocythemia	12.6	ITGA2, ITGB2, ITGB3
25	macrothrombocytopenia	12.6	ITGB3, ITGA2B
26	vascular disease	12.5	ITGA2, ITGB3, MMRN1
27	blood platelet disease	12.5	ITGA2B, MMRN1
28	atrial fibrillation	12.4	MMRN1, ITGB3, ITGA2
29	takayasu's arteritis	12.4	ITGA2B, ITGB3
30	migraine without aura	12.4	ITGA2, ITGB2, ITGB3
31	myocarditis	12.4	HLA-DRB3, ITGB3, ITGB2
32	retinal vein occlusion	12.3	ITGA2, ITGA2B, ITGB3
33	pre-eclampsia	12.3	ITGA2, ITGB2, ITGB3
34	sickle cell anemia	12.3	ITGA2, ITGA2B, ITGB3
35	arteriosclerosis	12.3	ITGA2, ITGA2B, ITGB3
36	eclampsia	12.2	ITGA2, ITGB2, ITGB3
37	cerebrovascular disease	12.2	ITGB3, ITGA2B, ITGA2
38	cerebrovascular accident	12.2	ITGA2, ITGA2B, ITGB3
39	sickle cell disease	12.2	ITGA2, ITGA2B, ITGB3
40	factor v leiden thrombophilia	12.2	ITGA2, ITGA2B, ITGB3
41	glomerulonephritis	12.1	ITGA2, ITGB2, ITGB3
42	cadasil	12.1	MMRN1, ITGB3, ITGB2, ITGA2
43	bartter disease	12.0	MMRN1, ITGB3, ITGB2, ITGA2
44	periodontitis	12.0	HLA-DRB3, MMRN1, ITGB2, ITGA2
45	dmd-associated dilated cardiomyopathy	11.9	ITGA2, ITGA2B, ITGB3
46	coronary artery anomaly	11.8	ITGB3, ITGB2, ITGA2B, ITGA2
47	asthma	11.6	HLA-DRB3, MMRN1, ITGB3, ITGB2, ITGA2
48	diabetic retinopathy	11.3	MMRN1, ITGB3, ITGB2, ITGA2B, ITGA2
49	diabetes mellitus	11.3	HLA-DRB3, ITGB3, ITGB2, ITGA2B, ITGA2
50	atherosclerosis	11.1	ITGA2, ITGA2B, ITGB2, ITGB3, POU2F3

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 anagrelide, anagrelide hydrochloride, argatroban, danaparoid, danaparoid sodium, desmopressin, desmopressin acetate, interferon, interferon alfa 2-b, interferon alfa-2a, interferon alfa-2a,recombinant, interferon alfa-2b,recombinant, interferon alfa-3n,human leukocyte derived, interferon alfacon-1, interferon beta-1a,recombinant, interferon beta-1b,recombinant, interferon gamma-1b, lepirudin, peginterferon alfa-2a, peginterferon alfa-2b

MalaCards organs/tissues related to neonatal alloimmune thrombocytopenia:

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Articles related to neonatal alloimmune thrombocytopenia:

id	Title	Authors	Year	Affiliating Genes
1	New low-frequency platelet glycoprotein polymorphisms associated with neonatal alloimmune thrombocytopenia. (19821948)	Peterson J.A.... Aster R.	2010	ITGB2, ITGB3
2	T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells. (19136661)	Ahlen M.T.... Stuge T.B.	2009	HLA-DRB3
3	HPA-13bw neonatal alloimmune thrombocytopenia and low frequency alloantigens: case report and review of the literature. (17655596)	Bertrand G.... Kaplan C.	2007	MMRN1
4	A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. (16317099)	Ni H.... Freedman J.	2006	ITGB3
5	A functional platelet fibrinogen receptor with a deletion in the cysteine-rich repeat region of the beta(3) integrin: the Oe(a) alloantigen in neonatal alloimmune thrombocytopenia. (11830467)	Santoso S.... Kroll H.	2002	ITGB3
6	Prediction of neonatal alloimmune thrombocytopenia us ing PCR. (8165025)	Marshall L.R.... Munro T.E.	1994	POU2F3
7	Single point mutation in human glycoprotein IIIa is associated with a new platelet-specific alloantigen (Mo) involved in neonatal alloimmune thrombocytopenia. (8093349)	Kuijpers R.W.A.M.... von dem Borne A.E.G.K.	1993	ITGB3

Genes related to neonatal alloimmune thrombocytopenia according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	ITGA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	11.1	Summaries
2	ITGB3	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	11.0	Functions, Publications
3	HLA-DRB3	major histocompatibility complex, class II, DR beta 3	11.0	Publications
4	POU2F3	POU class 2 homeobox 3	11.0	Publications
5	MMRN1	multimerin 1	11.0	Publications
6	ITGA2B	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	11.0	UniProt Related
7	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	11.0	Publications

Pathways related to neonatal alloimmune thrombocytopenia according to GeneDecks:

(show all 48)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion_Integrin inside-out signaling41	10.1	ITGB3, ITGA2
2	Cell adhesion_Endothelial cell contacts by non-junctional mechanisms41	9.7	ITGA2, ITGB3
3	Cell adhesion Endothelial cell contacts by non-junctional mechanisms10	9.6	ITGB3, ITGA2
4	Viral myocarditis20	9.5	HLA-DRB3, ITGB2
5	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics34	9.2	ITGA2B, ITGA2, ITGB3
6	Staphylococcus aureus infection20	9.2	HLA-DRB3, ITGB2
7	Arrhythmogenic right ventricular cardiomyopathy (ARVC)20	9.2	ITGB3, ITGA2B, ITGA2
8	Hypertrophic cardiomyopathy (HCM)20	9.2	ITGA2B, ITGA2, ITGB3
9	ECM-receptor interaction20	9.2	ITGA2, ITGB3, ITGA2B
10	Dilated cardiomyopathy20	9.1	ITGA2, ITGA2B, ITGB3
11	Phagosome20	9.1	ITGA2, ITGB2, ITGB3, HLA-DRB3
12	Focal adhesion20	9.0	ITGB3, ITGA2B, ITGA2
13	Hematopoietic cell lineage20	8.8	HLA-DRB3, ITGB3, ITGA2B, ITGA2
14	Phagocytosis of Microbes36	8.8	ITGB2, ITGA2B, ITGB3, ITGA2
15	Cell adhesion Integrin inside-out signaling10	8.8	ITGB2, ITGA2, ITGA2B, ITGB3
16	HGF Pathway36	8.8	ITGA2, ITGA2B, ITGB2, ITGB3
17	Reelin Pathway (Cajal-Retzius cells)36	8.8	ITGB2, ITGA2B, ITGA2, ITGB3
18	Calpain Protease Regulates Cellular Mechanics36	8.8	ITGB2, ITGB3, ITGA2B, ITGA2
19	Actin Nucleation and Branching36	8.8	ITGA2B, ITGB3, ITGA2, ITGB2
20	RhoA Pathway36	8.8	ITGA2, ITGB2, ITGA2B, ITGB3
21	Glioma Invasiveness36	8.8	ITGA2B, ITGB2, ITGB3, ITGA2
22	UPA-UPAR Pathway36	8.8	ITGA2, ITGA2B, ITGB2, ITGB3
23	Actin Nucleation by ARP-WASP Complex36	8.8	ITGA2, ITGB3, ITGB2, ITGA2B
24	FAK1 Signaling36	8.8	ITGB3, ITGB2, ITGA2B, ITGA2
25	Sertoli-Sertoli Cell Junction Dynamics36	8.8	ITGB3, ITGA2, ITGB2, ITGA2B
26	CDK5 Pathway36	8.7	ITGB2, ITGB3, ITGA2, ITGA2B
27	Regulation of eIF4 and p70S6K36	8.7	ITGA2, ITGA2B, ITGB2, ITGB3
28	PPAR Pathway36	8.7	ITGB2, ITGB3, ITGA2, ITGA2B
29	Integrin Pathway36	8.7	ITGB2, ITGA2, ITGB3, ITGA2B
30	Regulation of actin cytoskeleton20	8.7	ITGB3, ITGB2, ITGA2B, ITGA2
31	Rac1 Pathway36	8.7	ITGA2B, ITGA2, ITGB2, ITGB3
32	Signaling Involved in Cardiac Hypertrophy36	8.7	ITGB2, ITGA2, ITGA2B, ITGB3
33	Actin-Based Motility by Rho Family GTPases36	8.7	ITGA2, ITGB3, ITGA2B, ITGB2
34	Paxillin Interactions36	8.7	ITGA2, ITGB2, ITGB3, ITGA2B
35	Rap1 Pathway36	8.7	ITGA2B, ITGB3, ITGA2, ITGB2
36	GnRH Signaling36	8.7	ITGB3, ITGA2, ITGA2B, ITGB2
37	Ras Pathway36	8.7	ITGA2B, ITGA2, ITGB3, ITGB2
38	Epithelial Tight Junctions36	8.7	ITGB2, ITGA2B, ITGA2, ITGB3
39	PTEN Pathway36	8.7	ITGA2, ITGA2B, ITGB2, ITGB3
40	Tec Kinases Signaling36	8.6	ITGA2B, ITGB3, ITGA2, ITGB2
41	Transendothelial Migration of Leukocytes36	8.6	ITGB2, ITGA2B, ITGA2, ITGB3
42	Phospholipase-C Pathway36	8.6	ITGA2B, ITGA2, ITGB2, ITGB3
43	MAPK Signaling36	8.6	ITGB3, ITGA2, ITGB2, ITGA2B
44	Akt Signaling36	8.5	ITGB3, ITGB2, ITGA2B, ITGA2
45	Rho Family GTPases36	8.5	ITGB3, ITGB2, ITGA2B, ITGA2
46	ERK Signaling36	8.5	ITGB3, ITGA2B, ITGB2, ITGA2
47	Molecular Mechanisms of Cancer36	8.4	ITGB2, ITGA2B, ITGA2, ITGB3
48	CDC42 Pathway36	8.3	ITGA2, HLA-DRB3, ITGB3, ITGB2, ITGA2B

Compounds related to neonatal alloimmune thrombocytopenia according to GeneDecks:

(show all 13)

id	Compound	Score	Top Affiliating Genes
1	gr 144053 trihydrochloride42	9.5	ITGA2B, ITGB3
2	mns42	9.4	ITGA2B, ITGB3
3	echistatin, alpha1 isoform 42	9.4	ITGB3, ITGA2B
4	rgds peptide42	9.4	ITGB3, ITGA2B
5	abciximab32 9 9	11.4	ITGA2B, ITGB2
6	polyacrylamide32	9.2	ITGA2, ITGB2, ITGB3
7	tirofiban32 9 9	11.1	ITGA2, ITGA2B, ITGB3
8	okt332	9.0	MMRN1, ITGB2
9	12-o-tetradecanoylphorbol 13-acetate32	8.7	ITGB2, ITGA2B, ITGA2
10	lysine32	8.5	ITGB3, ITGA2B, ITGA2, ITGB2
11	adp32 18	9.3	ITGB3, ITGB2, ITGA2B, ITGA2
12	cysteine32	8.3	ITGB3, ITGB2, ITGA2B, ITGA2
13	fibrinogen32	8.0	ITGA2, ITGB3, ITGB2, ITGA2B, MMRN1

Cellular components related to neonatal alloimmune thrombocytopenia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule membrane	GO:031092	8.9	ITGA2B, ITGB3
2	external side of plasma membrane	GO:009897	8.8	ITGA2, ITGA2B, HLA-DRB3
3	integrin complex	GO:008305	8.2	ITGA2, ITGA2B, ITGB2, ITGB3

Biological processes related to neonatal alloimmune thrombocytopenia according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	wound healing	GO:042060	9.5	ITGB3, POU2F3
2	platelet degranulation	GO:002576	8.6	ITGB3, ITGA2B, MMRN1
3	axon guidance	GO:007411	8.6	ITGB3, ITGA2, ITGA2B
4	integrin-mediated signaling pathway	GO:007229	8.5	ITGB2, ITGB3, ITGA2B, ITGA2
5	platelet activation	GO:030168	8.5	MMRN1, ITGB3, ITGA2B
6	cell-matrix adhesion	GO:007160	8.5	ITGB3, ITGB2, ITGA2B, ITGA2
7	cell adhesion	GO:007155	7.8	MMRN1, ITGB3, ITGB2, ITGA2B, ITGA2
8	blood coagulation	GO:007596	7.8	ITGA2B, MMRN1, ITGB2, ITGB3, ITGA2