Aliases & Classifications for Neonatal Anemia

MalaCards integrated aliases for Neonatal Anemia:

Name: Neonatal Anemia 12 14
Anemia, Neonatal 41 69
Anemia Neonatal 12 51

Classifications:



External Ids:

Disease Ontology 12 DOID:11244
MeSH 41 D000751
UMLS 69 C0002891

Summaries for Neonatal Anemia

MalaCards based summary : Neonatal Anemia, also known as anemia, neonatal, is related to thalassemia and beta-thalassemia. An important gene associated with Neonatal Anemia is EPO (Erythropoietin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation and Paxillin-dependent events mediated by a4b1. The drugs Iron and Citric Acid have been mentioned in the context of this disorder. Affiliated tissues include pituitary, testes and placenta, and related phenotypes are mortality/aging and respiratory system

Related Diseases for Neonatal Anemia

Diseases related to Neonatal Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 thalassemia 29.4 EPO HBA2 HBG1
2 beta-thalassemia 29.0 EPO HBA2 HBG1 KLF1
3 neonatal autoimmune hemolytic anemia 10.9
4 hemoglobin h disease 10.2 EPO HBA2
5 tubulinopathy-associated dysgyria 10.2 TUBB2B TUBB3
6 microcytic anemia 10.2 EPO HBA2
7 hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome 10.2 HBG1 KLF1
8 hereditary persistence of fetal hemoglobin-sickle cell disease syndrome 10.1 HBG1 KLF1
9 paralytic squint 10.1 TUBB2B TUBB3
10 tubulin, beta 10.1 TUBB2B TUBB3
11 tukel syndrome 10.1 TUBB2B TUBB3
12 sickle cell disease 10.0 EPO HBA2 HBG1
13 sickle cell anemia 10.0 EPO HBA2 HBG1
14 alpha-thalassemia 10.0 EPO HBA2 HBG1
15 acquired polycythemia 9.9 EPO EPOR
16 erythrocytosis, familial, 2 9.9 EPO EPOR
17 primary polycythemia 9.9 EPO EPOR
18 congenital nervous system abnormality 9.9 TUBB2B TUBB3
19 ewing's family of tumors 9.9 EPO EPOR
20 exudative vitreoretinopathy 1 9.9 EPO SERPINH1
21 anemia of prematurity 9.9 EPO EPOR
22 erythrocytosis, familial, 1 9.8 EPO EPOR
23 hemangioblastoma 9.8 EPO EPOR
24 deficiency anemia 9.7 EPO EPOR HBA2
25 hemoglobinopathy 9.7 EPO HBA2 HBG1 KLF1
26 congenital hemolytic anemia 9.7 EPO HBA2 HBG1 KLF1
27 fetal hemoglobin quantitative trait locus 1 9.7
28 diamond-blackfan anemia 9.6 EPO EPOR KLF1
29 elliptocytosis 2 9.5
30 ovalocytosis, southeast asian 9.5
31 blood group, junior system 9.5
32 hydrops fetalis, nonimmune, and/or atrial septal defect 9.5
33 hemolytic anemia 9.5
34 thrombocytopenia 9.5
35 cerebritis 9.5
36 choriocarcinoma 9.5
37 myofibroma 9.5
38 hydrops fetalis 9.5
39 polycythemia 9.5 EPO EPOR
40 acute erythroid leukemia 9.3 EPO EPOR HBG1 KLF1

Graphical network of the top 20 diseases related to Neonatal Anemia:



Diseases related to Neonatal Anemia

Symptoms & Phenotypes for Neonatal Anemia

MGI Mouse Phenotypes related to Neonatal Anemia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.5 EPO EPOR HBA2 KLF1 SERPINH1 TUBB2B
2 respiratory system MP:0005388 9.02 EPO EPOR SERPINH1 TUBB2B TUBB3

Drugs & Therapeutics for Neonatal Anemia

Drugs for Neonatal Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 2, Phase 3 7439-89-6 23925
2
Citric Acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
3 Sildenafil Citrate Phase 3 171599-83-0
4 Chelating Agents Phase 3
5 Hematinics Phase 2, Phase 3
6 Vasodilator Agents Phase 3
7 Dextrans Phase 2, Phase 3
8 Anticoagulants Phase 3,Phase 2,Not Applicable
9 Epoetin alfa Phase 2, Phase 3 113427-24-0
10 Phosphodiesterase 5 Inhibitors Phase 3
11 Phosphodiesterase Inhibitors Phase 3
12 Iron-Dextran Complex Phase 2, Phase 3
13 Calcium, Dietary Phase 3
14 Vaccines Phase 3
15 Immunoglobulins Phase 3
16 Antibodies Phase 3
17 Citrate Nutraceutical Phase 3
18
Biotin Approved, Investigational, Nutraceutical Phase 2 58-85-5 171548
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
20 Micronutrients Phase 2
21 Trace Elements Phase 2
22 Vitamin B Complex Phase 2
23 Vitamins Phase 2
24 Folate Nutraceutical Phase 2
25 Vitamin B7 Nutraceutical Phase 2
26 Vitamin B9 Nutraceutical Phase 2
27
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
28
Lidocaine Approved, Vet_approved Not Applicable 137-58-6 3676
29 Racepinephrine Approved Not Applicable 329-65-7
30
Glucosamine Approved, Investigational, Nutraceutical Not Applicable 3416-24-8 439213
31 Fibrinolytic Agents Not Applicable
32 Glucuronyl glucosamine glycan sulfate Not Applicable
33 Anesthetics Not Applicable
34 Anti-Bacterial Agents Not Applicable
35 Epinephryl borate Not Applicable
36 Hypoglycemic Agents Not Applicable
37 Hypolipidemic Agents Not Applicable
38 Antimetabolites Not Applicable
39 Lipid Regulating Agents Not Applicable
40 Antibiotics, Antitubercular Not Applicable
41 Anesthetics, Local Not Applicable

Interventional clinical trials:

(show all 26)

# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial Comparing a Conservative Management and Laser Surgery Recruiting NCT01220011 Phase 4
2 A Trial Evaluating the Role of Sildenafil in the Treatment of Fetal Growth Restriction Completed NCT02590536 Phase 3 Sildenafil citrate;placebo
3 The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Very Low Birth Weight Infants Completed NCT01203514 Phase 2, Phase 3 Erythropoietin
4 Effect of Placental Drainage of Fetal Blood at Cesarean Section on the Incidence of Feto-Maternal Transfusion Completed NCT00470899 Phase 3
5 Clinical Efficacy of Postpartum Immunization of Rh and Coombs Negative Women With Sensitization Risk. Recruiting NCT01666249 Phase 3
6 Immediate VS Delayed Cord Clamping on Newborns Unknown status NCT01029496 Phase 1, Phase 2
7 Red Blood Cell (RBC) Survival Following Transfusion in Infants Completed NCT00731588 Phase 2
8 Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants Completed NCT01081977 Phase 2
9 Optimized Erythropoietin (EPO) Treatment Active, not recruiting NCT02075970 Phase 2 Epoetin Alpha;Biotinylated Red Blood Cells
10 Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates Unknown status NCT02050971 Phase 1
11 Feasibility and Safety of Umbilical Cord Blood Transfusion in the Treatment of Neonatal Cerebral Ischemia and Anemia Recruiting NCT03352310 Phase 1
12 Fetoscopic Selective Laser Photocoagulation in Twin-Twin Transfusion Syndrome Unknown status NCT00345852 Not Applicable
13 Milking Versus Delayed Cord Clamping in Full Term Neonates Completed NCT02454101
14 Identification of Early Predictors of Fetomaternal Hemorrhage Completed NCT01232387
15 Neonatal Outcome for Laser Coagulation in Twin-to-twin-transfusion Syndrome Completed NCT03151915
16 Selective Laser Photocoagulation of Communicating Vessels in Twin-Twin Transfusion Syndrome Completed NCT01622049 Not Applicable
17 Austrian Registry on the Outcome of Monochorionic Pregnancies Recruiting NCT03171909
18 Renal Artery Dopplers in Twin Twin Transfusion Syndrome Recruiting NCT03449823
19 Sequential vs. Standard Laser Treatment of Twin-twin Transfusion Syndrome Recruiting NCT02122328 Not Applicable
20 The Trial of Pessary After Laser for TTTS Recruiting NCT01334489 Not Applicable
21 Determinants of Neonatal Anemia in Women Carrying Multiples Active, not recruiting NCT01582802
22 The Utility of MRI Scoring to Predict Neurodevelopmental Outcomes in Survivors of Twin-to-Twin Transfusion Syndrome Active, not recruiting NCT02249624
23 Monochorial-diamniotic Pregnancies Complicated With a Twin-to-twin Syndrome Active, not recruiting NCT02611856
24 Research of Systemic Management for Late Preterm Infants Nutrition in China Enrolling by invitation NCT02605577
25 Laser Photocoagulation in Twin to Twin Transfusion Syndrome Enrolling by invitation NCT02506049 Not Applicable
26 Clinical Performance of the Histidine Rich Protein 2 (HRP2) Highly Sensitive Rapid Diagnostic Test (HS-RDT) for Malaria Diagnosis in Pregnant Women in Papua New Guinea Not yet recruiting NCT03462615

Search NIH Clinical Center for Neonatal Anemia

Cochrane evidence based reviews: anemia, neonatal

Genetic Tests for Neonatal Anemia

Anatomical Context for Neonatal Anemia

MalaCards organs/tissues related to Neonatal Anemia:

38
Pituitary, Testes, Placenta

Publications for Neonatal Anemia

Articles related to Neonatal Anemia:

(show top 50) (show all 53)
# Title Authors Year
1
Neonatal anemia: Revisiting the enigmatic pyknocyte. ( 28335086 )
2017
2
A Solitary Intestinal Myofibroma: A Rare Cause of Neonatal Anemia. ( 29279689 )
2017
3
Epsilon gamma delta beta thalassemia: A rare cause of fetal and neonatal anemia. ( 29162270 )
2017
4
Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development. ( 28143845 )
2017
5
Management and prevention of neonatal anemia: current evidence and guidelines. ( 24524256 )
2014
6
A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia. ( 23033916 )
2013
7
Imaging diagnosis of neonatal anemia: report of two unusual etiologies. ( 24605254 )
2013
8
Severe neonatal anemia from fetomaternal hemorrhage: report from a multihospital health-care system. ( 23196720 )
2013
9
A novel epsilon gamma delta beta thalassemia presenting with pregnancy complications and severe neonatal anemia. ( 23206178 )
2013
10
Clinical and research issues in neonatal anemia and thrombocytopenia. ( 22227780 )
2012
11
Doppler middle cerebral artery peak systolic velocity for diagnosis of neonatal anemia. ( 22922618 )
2012
12
Nonpharmacological, blood conservation techniques for preventing neonatal anemia--effective and promising strategies for reducing transfusion. ( 22818543 )
2012
13
Intrahepatic and adrenal hemorrhage as a rare cause of neonatal anemia. ( 21388342 )
2011
14
Fetal and neonatal anemia associated with anti-Jr(a) : a case report showing a poorly hemolytic mechanism. ( 21481087 )
2011
15
Risk factors of neonatal anemia in placenta previa. ( 21960747 )
2011
16
Infantile pyknocytosis: a rare form of neonatal anemia. ( 20684190 )
2010
17
Erythropoietin pharmacokinetic/pharmacodynamic analysis suggests higher doses in treating neonatal anemia. ( 19371274 )
2009
18
Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan). ( 19409822 )
2009
19
Treatment and Prevention of Neonatal Anemia. ( 20209037 )
2008
20
Neonatal anemia. ( 18411074 )
2008
21
Assessment of neonatal anemia. ( 17453046 )
2007
22
Neonatal anemia and hydrops fetalis after maternal mycophenolate mofetil use. ( 17180133 )
2007
23
Neonatal anemia associated with Southeast Asian ovalocytosis. ( 16207591 )
2005
24
Profound early-onset neonatal anemia: a case study. ( 12943209 )
2002
25
Hb Dartmouth [alpha66(E15)Leu-->Pro (alpha2) (CTG-->CCG)]: a novel alpha2-globin gene mutation associated with severe neonatal anemia when inherited in trans with Southeast Asian alpha-thalassemia-1. ( 11791870 )
2001
26
[Neonatal anemia and Rhesus incompatibility: is there a place for erythropoietin?]. ( 11147059 )
2000
27
Management of severe neonatal anemia due to fetomaternal transfusion. ( 10458533 )
1999
28
[Prevention of neonatal anemia with recombinant human erythropoietin: a cost-benefit analysis]. ( 10612190 )
1999
29
[Recombinant erythropoietin and early preterm neonatal anemia]. ( 10476641 )
1999
30
The nonreactive nonstress test: predictive value for neonatal anemia in the isoimmunized pregnancy. ( 8752240 )
1996
31
Neonatal anemia: pathophysiology and treatment. ( 7713595 )
1995
32
Recombinant human erythropoietin in neonatal anemia. ( 8521685 )
1995
33
Erythropoietin in the pathogenesis and treatment of neonatal anemia. ( 7998075 )
1995
34
Erythropoietin and neonatal anemia. ( 8139633 )
1994
35
Unusual clinical features of neonatal anemia due to fetomaternal transfusion. ( 8333290 )
1993
36
The changing pattern of maternal and neonatal anemia at Udaipur during 2 decades in relation to poverty, parity, prematurity and vegetarianism. ( 2064586 )
1991
37
Fetal hemoglobin in neonatal anemia. ( 1702888 )
1991
38
Management of neonatal anemia in the delivery room. ( 2094675 )
1990
39
Evaluation of a new method for the prevention of neonatal anemia. ( 2704595 )
1989
40
Nuchal cord as a cause of neonatal anemia. ( 4036898 )
1985
41
Diamond-Blackfan anemia. Neonatal presentation as Rh incompatibility, hemolysis, and active erythropoiesis. ( 4083394 )
1985
42
Nuchal cord as a cause of neonatal anemia. ( 3969987 )
1985
43
Severe neonatal anemia possibly caused by spontaneous cephalic version, with excellent outcome--a case report. ( 6502441 )
1984
44
Choriocarcinoma with neonatal anemia. ( 584929 )
1977
45
Severe neonatal anemia due to massive transplacental hemorrhage. ( 6021546 )
1967
46
Relation of time of ligation of umbilical cord to neonatal anemia. ( 5183183 )
1967
47
Congenital neonatal anemia in Hanford miniature swine. BNWL-280. ( 5301031 )
1966
48
Relation of maternal fetal hemoglobin and bilirubin to neonatal anemia, type of delivery, and outcome of pregnancy. ( 13977769 )
1963
49
Neonatal anemia due to water-soluble vitamin K analogue: case report. ( 13712478 )
1961
50
Neonatal anemia due to transplacental blood loss; a case report. ( 13661246 )
1959

Variations for Neonatal Anemia

Expression for Neonatal Anemia

Search GEO for disease gene expression data for Neonatal Anemia.

Pathways for Neonatal Anemia

Pathways related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.84 EPO KLF1
2
Show member pathways
10.6 EPO EPOR
3 10.05 EPO EPOR

GO Terms for Neonatal Anemia

Cellular components related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemoglobin complex GO:0005833 8.62 HBA2 HBG1

Biological processes related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 erythrocyte differentiation GO:0030218 9.26 EPO KLF1
2 microtubule-based process GO:0007017 9.16 TUBB2B TUBB3
3 oxygen transport GO:0015671 8.96 HBA2 HBG1
4 erythropoietin-mediated signaling pathway GO:0038162 8.62 EPO EPOR

Molecular functions related to Neonatal Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 8.96 HBA2 HBG1
2 oxygen carrier activity GO:0005344 8.62 HBA2 HBG1

Sources for Neonatal Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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