MCID: NNT011
MIFTS: 33

Neonatal Anemia malady

Categories: Blood diseases

Aliases & Classifications for Neonatal Anemia

Aliases & Descriptions for Neonatal Anemia:

Name: Neonatal Anemia 12 14
Anemia, Neonatal 42 69
Anemia Neonatal 12 52

Classifications:



External Ids:

Disease Ontology 12 DOID:11244
MeSH 42 D000751
UMLS 69 C0002891

Summaries for Neonatal Anemia

MalaCards based summary : Neonatal Anemia, also known as anemia, neonatal, is related to neonatal autoimmune hemolytic anemia and tmem216-related meckel syndrome. An important gene associated with Neonatal Anemia is EPO (Erythropoietin), and among its related pathways/superpathways are Jak/STAT Signaling Pathway and Hematopoietic Stem Cell Differentiation. The drugs Iron and Pyrimethamine have been mentioned in the context of this disorder. Affiliated tissues include pituitary, testes and placenta, and related phenotype is Decreased viability after Maraba virus infection.

Related Diseases for Neonatal Anemia

Diseases related to Neonatal Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
id Related Disease Score Top Affiliating Genes
1 neonatal autoimmune hemolytic anemia 10.8
2 tmem216-related meckel syndrome 10.2 EPO HBA2
3 adenosine triphosphate, elevated, of erythrocytes 10.2 EPO HBA2
4 cat-scratch disease 10.1 EPO HBA2
5 long qt syndrome 10.1 EPO EPOR
6 atrioventricular septal defect 2 10.1 EPO EPOR
7 tmem237-related joubert syndrome 10.1 EPO HBA2 KLF1
8 larynx sarcoma 10.1 EPO HBA2 KLF1
9 meningeal melanocytoma 10.1 EPO HBA2 KLF1
10 queensland tick typhus 10.1 EPO EPOR
11 thalassemia-beta, dominant inclusion-body 10.1 EPO HBA2 KLF1
12 tracheal cancer 10.1 EPO HBA2 KLF1
13 cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1 10.1 EPO EPOR
14 gastrointestinal anthrax 10.1 KIF23 KLF1
15 albinism, oculocutaneous, type ib 10.1 EPO SERPINH1
16 extranodal nasal nk/t cell lymphoma 10.1 EPO EPOR
17 tk2-related mitochondrial dna depletion syndrome, myopathic form 10.1 EPO HBA2
18 dic in newborn 10.0 EPO EPOR
19 granular cell leiomyosarcoma 10.0 EPO EPOR
20 fetal hemoglobin quantitative trait locus 1 10.0 EPO HBA2
21 acute liver failure 10.0 EPO EPOR KLF1
22 drug-induced hepatitis 9.9 EPO EPOR KLF1
23 diamond-blackfan anemia 9.4
24 hemolytic anemia 9.4
25 thalassemia 9.4
26 thrombocytopenia 9.4
27 cerebritis 9.4
28 choriocarcinoma 9.4
29 hydrops fetalis 9.4
30 disseminated intravascular coagulation 8.8 ACCS CMC2 EPO EPOR HBA2 KIF23

Graphical network of the top 20 diseases related to Neonatal Anemia:



Diseases related to Neonatal Anemia

Symptoms & Phenotypes for Neonatal Anemia

GenomeRNAi Phenotypes related to Neonatal Anemia according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability after Maraba virus infection GR00252-A-1 9.28 ACCS EPOR KIF23
2 Decreased viability after Maraba virus infection GR00252-A-2 9.28 ACCS CMC2 EPOR KIF23
3 Decreased viability after Maraba virus infection GR00252-A-3 9.28 CMC2 EPOR

Drugs & Therapeutics for Neonatal Anemia

Drugs for Neonatal Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 208)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 2,Phase 3 7439-89-6 23925
2
Pyrimethamine Approved, Vet_approved Phase 4,Phase 3 58-14-0 4993
3
Sulfadoxine Approved Phase 4,Phase 3 2447-57-6 17134
4
Copper Approved Phase 4 15158-11-9, 7440-50-8 27099
5
Hydroxocobalamin Approved Phase 4,Phase 3 13422-51-0 11953898 5460373 44475014
6
Selenium Approved, Vet_approved Phase 4,Phase 3 7782-49-2
7
Zinc Approved Phase 4 7440-66-6 32051 23994
8
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
9
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
10
Lumefantrine Approved Phase 4,Phase 3 82186-77-4 6437380
11
Levoleucovorin Approved Phase 4 68538-85-2
12
Spiramycin Approved Phase 4 24916-50-5
13
Sulfadiazine Approved, Vet_approved Phase 4 68-35-9 5215
14
Desogestrel Approved Phase 4 54024-22-5 40973
15
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
16
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
17
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
18
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 3 68-19-9 44176380
19
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3 59-67-6 938
20
Nicotinamide Approved, Nutraceutical Phase 4,Phase 3 98-92-0 936
21
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
22
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 65-23-6 1054
23
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 83-88-5 493570
24
Thiamine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-43-8 1130
25
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 11103-57-4, 68-26-8 445354
26
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
27
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
28 Micronutrients Phase 4,Phase 3,Phase 2
29 Trace Elements Phase 4,Phase 3,Phase 2
30 Pharmaceutical Solutions Phase 4,Phase 1,Phase 2
31 Hematinics Phase 4,Phase 2,Phase 3,Phase 1
32 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1
33 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
34 Antimalarials Phase 4,Phase 3,Phase 1
35 Antiparasitic Agents Phase 4,Phase 3,Phase 1
36 Antiprotozoal Agents Phase 4,Phase 3,Phase 1
37 Folic Acid Antagonists Phase 4,Phase 3,Phase 2,Phase 1
38 Renal Agents Phase 4,Phase 3
39 Fanasil, pyrimethamine drug combination Phase 4,Phase 3
40 Antibodies Phase 4,Phase 3
41 gamma-Globulins Phase 4
42 Immunoglobulins Phase 4,Phase 3
43 Immunoglobulins, Intravenous Phase 4
44 Rho(D) Immune Globulin Phase 4
45 cadexomer iodine Phase 4,Phase 3
46
Iodine Phase 4,Phase 3 7553-56-2 807
47 Nicotinic Acids Phase 4,Phase 3
48 Retinol palmitate Phase 4,Phase 2
49 Tocopherols Phase 4
50 Tocotrienols Phase 4

Interventional clinical trials:

(show top 50) (show all 136)
id Name Status NCT ID Phase
1 Iron Supplementation of Marginally Low Birth Weight Infants Unknown status NCT00558454 Phase 4
2 Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic Disease Completed NCT00288600 Phase 4
3 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
4 Safety of Cotrimoxazole in HIV- and HAART-exposed Infants Completed NCT01086878 Phase 4
5 Resistance Exercise Training During Pregnancy: a Randomized Controlled Trial Completed NCT00813657 Phase 4
6 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4
7 Intermittent Preventive Treatment Versus Scheduled Screening and Treatment of Malaria in Pregnancy Completed NCT01084213 Phase 4
8 Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia Completed NCT00270530 Phase 4
9 IPT of Malaria With SP in Different Zones of Drug Resistance in Rwanda Completed NCT00372632 Phase 4
10 Randomized Controlled Trial Comparing a Conservative Management and Laser Surgery Recruiting NCT01220011 Phase 4
11 Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency Recruiting NCT02594904 Phase 4
12 Supplementing Iron and Development in Breastfed Infants (SIDBI Study) Recruiting NCT02242188 Phase 4
13 Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis Recruiting NCT00004317 Phase 4
14 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4
15 Treatment and Prevention of Severe Anemia in Pregnant Zanzibari Women Unknown status NCT00148629 Phase 3
16 The Pakistan Early Childhood Development Scale Up Trial Unknown status NCT00715936 Phase 2, Phase 3
17 Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant Diseases Unknown status NCT01019876 Phase 2, Phase 3
18 The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Very Low Birth Weight Infants Completed NCT01203514 Phase 2, Phase 3
19 Effect of Placental Drainage of Fetal Blood at Cesarean Section on the Incidence of Feto-Maternal Transfusion Completed NCT00470899 Phase 3
20 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
21 a Randomized Multicenter Trial Comparing Vacuum Assisted Delivery With the New Device "iCUP" Versus the Reference Cup. Completed NCT01058200 Phase 3
22 Establishing Effectiveness of Daily Co-trimoxazole Prophylaxis For Prevention of Malaria in Pregnancy Completed NCT01053325 Phase 3
23 Impact of Prenatal Vitamin/Mineral Supplements on Perinatal Mortality Completed NCT00133744 Phase 3
24 Intermittent Preventive Treatment (IPTp) Versus Rapid Diagnostic Testing (RDT) and Treatment of Malaria in Pregnancy Completed NCT00432367 Phase 3
25 Supplementing Maternal and Infant Diet With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements (LNS) Completed NCT01239693 Phase 3
26 Chloroquine for Malaria in Pregnancy Completed NCT01443130 Phase 3
27 Gestational Sulfadoxine-pyrimethamine and Azithromycin Treatment to Prevent Preterm Birth Completed NCT00131235 Phase 3
28 Randomised Trial of 3 Artemisinin Combination Therapy for Malaria in Pregnancy Completed NCT01054248 Phase 3
29 Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women Completed NCT00993031 Phase 3
30 Clinical Efficacy of Postpartum Immunization of Rh and Coombs Negative Women With Sensitization Risk. Recruiting NCT01666249 Phase 3
31 Transfusion of Prematures Trial Recruiting NCT01702805 Phase 3
32 Oxygen Therapy and Pregnancy in Sickle Cell Disease Recruiting NCT02813850 Phase 3
33 EPO-4-Rhesus: Role of Darbepoetin Alfa in Reducing Late Anaemia in Neonates With Red Blood Cell Alloimmunization After Intrauterine Transfusions Not yet recruiting NCT03104426 Phase 2, Phase 3
34 A Trial Evaluating the Role of Sildenafil in the Treatment of Fetal Growth Restriction Not yet recruiting NCT02590536 Phase 3
35 Daily Co-trimoxazole Prophylaxis to Prevent Malaria in Pregnancy Terminated NCT00711906 Phase 3
36 Evaluate Azithromycin Plus Chloroquine And Sulfadoxine Plus Pyrimethamine Combinations For Intermittent Preventive Treatment Of Falciparum Malaria Infection In Pregnant Women In Africa Terminated NCT01103063 Phase 3
37 Immediate VS Delayed Cord Clamping on Newborns Unknown status NCT01029496 Phase 1, Phase 2
38 Darbepoetin Administration to Preterm Infants Unknown status NCT00334737 Phase 2
39 Milking the Umbilical Cord Versus Immediate Clamping in Pre-term Infants < 33 Weeks Unknown status NCT01819532 Phase 2
40 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2
41 Red Blood Cell (RBC) Survival Following Transfusion in Infants Completed NCT00731588 Phase 2
42 Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants Completed NCT01081977 Phase 2
43 Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy Completed NCT00808704 Phase 1, Phase 2
44 Phase II Randomized Study of Tin Mesoporphyrin for Neonatal Hyperbilirubinemia Completed NCT00004381 Phase 2
45 Randomized Study of Weekly Erythropoietin Dosing in Preterm Infants Completed NCT01235923 Phase 2
46 Cord Blood Stem Cell Transplantation Study (COBLT) Completed NCT00000603 Phase 2
47 Optimized Erythropoietin (EPO) Treatment Recruiting NCT02075970 Phase 2
48 Safety Study of Cord Blood Units for Stem Cell Transplants Recruiting NCT01861093 Phase 2
49 Single-dose Postpartum Vitamin A Supplementation of Mothers and Neonates Active, not recruiting NCT00198718 Phase 2
50 Realizing Effectiveness Across Continents With Hydroxyurea (REACH) Active, not recruiting NCT01966731 Phase 1, Phase 2

Search NIH Clinical Center for Neonatal Anemia

Cochrane evidence based reviews: anemia, neonatal

Genetic Tests for Neonatal Anemia

Anatomical Context for Neonatal Anemia

MalaCards organs/tissues related to Neonatal Anemia:

39
Pituitary, Testes, Placenta

Publications for Neonatal Anemia

Articles related to Neonatal Anemia:

(show all 48)
id Title Authors Year
1
Management and prevention of neonatal anemia: current evidence and guidelines. ( 24524256 )
2014
2
Severe neonatal anemia from fetomaternal hemorrhage: report from a multihospital health-care system. ( 23196720 )
2013
3
A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia. ( 23033916 )
2013
4
A novel epsilon gamma delta beta thalassemia presenting with pregnancy complications and severe neonatal anemia. ( 23206178 )
2013
5
Imaging diagnosis of neonatal anemia: report of two unusual etiologies. ( 24605254 )
2013
6
Doppler middle cerebral artery peak systolic velocity for diagnosis of neonatal anemia. ( 22922618 )
2012
7
Clinical and research issues in neonatal anemia and thrombocytopenia. ( 22227780 )
2012
8
Nonpharmacological, blood conservation techniques for preventing neonatal anemia--effective and promising strategies for reducing transfusion. ( 22818543 )
2012
9
Intrahepatic and adrenal hemorrhage as a rare cause of neonatal anemia. ( 21388342 )
2011
10
Fetal and neonatal anemia associated with anti-Jr(a) : a case report showing a poorly hemolytic mechanism. ( 21481087 )
2011
11
Risk factors of neonatal anemia in placenta previa. ( 21960747 )
2011
12
Infantile pyknocytosis: a rare form of neonatal anemia. ( 20684190 )
2010
13
Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan). ( 19409822 )
2009
14
Erythropoietin pharmacokinetic/pharmacodynamic analysis suggests higher doses in treating neonatal anemia. ( 19371274 )
2009
15
Neonatal anemia. ( 18411074 )
2008
16
Treatment and Prevention of Neonatal Anemia. ( 20209037 )
2008
17
Neonatal anemia and hydrops fetalis after maternal mycophenolate mofetil use. ( 17180133 )
2007
18
Assessment of neonatal anemia. ( 17453046 )
2007
19
Neonatal anemia associated with Southeast Asian ovalocytosis. ( 16207591 )
2005
20
Profound early-onset neonatal anemia: a case study. ( 12943209 )
2002
21
Hb Dartmouth [alpha66(E15)Leu-->Pro (alpha2) (CTG-->CCG)]: a novel alpha2-globin gene mutation associated with severe neonatal anemia when inherited in trans with Southeast Asian alpha-thalassemia-1. ( 11791870 )
2001
22
[Neonatal anemia and Rhesus incompatibility: is there a place for erythropoietin?]. ( 11147059 )
2000
23
Management of severe neonatal anemia due to fetomaternal transfusion. ( 10458533 )
1999
24
[Recombinant erythropoietin and early preterm neonatal anemia]. ( 10476641 )
1999
25
[Prevention of neonatal anemia with recombinant human erythropoietin: a cost-benefit analysis]. ( 10612190 )
1999
26
The nonreactive nonstress test: predictive value for neonatal anemia in the isoimmunized pregnancy. ( 8752240 )
1996
27
Erythropoietin in the pathogenesis and treatment of neonatal anemia. ( 7998075 )
1995
28
Recombinant human erythropoietin in neonatal anemia. ( 8521685 )
1995
29
Neonatal anemia: pathophysiology and treatment. ( 7713595 )
1995
30
Erythropoietin and neonatal anemia. ( 8139633 )
1994
31
Unusual clinical features of neonatal anemia due to fetomaternal transfusion. ( 8333290 )
1993
32
Fetal hemoglobin in neonatal anemia. ( 1702888 )
1991
33
The changing pattern of maternal and neonatal anemia at Udaipur during 2 decades in relation to poverty, parity, prematurity and vegetarianism. ( 2064586 )
1991
34
Management of neonatal anemia in the delivery room. ( 2094675 )
1990
35
Evaluation of a new method for the prevention of neonatal anemia. ( 2704595 )
1989
36
Nuchal cord as a cause of neonatal anemia. ( 4036898 )
1985
37
Nuchal cord as a cause of neonatal anemia. ( 3969987 )
1985
38
Severe neonatal anemia possibly caused by spontaneous cephalic version, with excellent outcome--a case report. ( 6502441 )
1984
39
Choriocarcinoma with neonatal anemia. ( 584929 )
1977
40
Severe neonatal anemia due to massive transplacental hemorrhage. ( 6021546 )
1967
41
Relation of time of ligation of umbilical cord to neonatal anemia. ( 5183183 )
1967
42
Congenital neonatal anemia in Hanford miniature swine. BNWL-280. ( 5301031 )
1966
43
Relation of maternal fetal hemoglobin and bilirubin to neonatal anemia, type of delivery, and outcome of pregnancy. ( 13977769 )
1963
44
Neonatal anemia due to water-soluble vitamin K analogue: case report. ( 13712478 )
1961
45
Fetal-maternal transfusion with consequent neonatal anemia; report of a case. ( 13661109 )
1959
46
Neonatal anemia due to transplacental blood loss; a case report. ( 13661246 )
1959
47
Neonatal anemia due to fetal hemorrhage into the maternal circulation. ( 13441371 )
1957
48
Prevention of neonatal anemia in the rat by the pituitary erythropoietic factor. ( 13230163 )
1955

Variations for Neonatal Anemia

Expression for Neonatal Anemia

Search GEO for disease gene expression data for Neonatal Anemia.

Pathways for Neonatal Anemia

Pathways related to Neonatal Anemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.08 EPO EPOR
2 10.84 EPO KLF1
3
Show member pathways
10.6 EPO EPOR
4 10.05 EPO EPOR

GO Terms for Neonatal Anemia

Biological processes related to Neonatal Anemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 erythrocyte differentiation GO:0030218 8.96 EPO KLF1
2 erythropoietin-mediated signaling pathway GO:0038162 8.62 EPO EPOR

Sources for Neonatal Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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