Aliases & Classifications for Neonatal Anemia

MalaCards integrated aliases for Neonatal Anemia:

Name: Neonatal Anemia 12 14
Anemia, Neonatal 42 69
Anemia Neonatal 12 52

Classifications:



External Ids:

Disease Ontology 12 DOID:11244
MeSH 42 D000751
UMLS 69 C0002891

Summaries for Neonatal Anemia

MalaCards based summary : Neonatal Anemia, also known as anemia, neonatal, is related to sickle cell anemia and neonatal autoimmune hemolytic anemia. An important gene associated with Neonatal Anemia is EPO (Erythropoietin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation and Paxillin-dependent events mediated by a4b1. The drugs Iron and Copper have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and neutrophil, and related phenotypes are mortality/aging and respiratory system

Related Diseases for Neonatal Anemia

Diseases related to Neonatal Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
id Related Disease Score Top Affiliating Genes
1 sickle cell anemia 29.4 EPO HBA2 KLF1
2 neonatal autoimmune hemolytic anemia 10.8
3 timothy syndrome type 2 10.5 EPO HBA2
4 pyruvate kinase deficiency 10.5 EPO HBA2
5 cat-scratch disease 10.4 EPO HBA2
6 spastic paraplegia 8 10.4 EPO HBA2
7 autosomal recessive spastic paraplegia type 68 10.2 TUBB2B TUBB3
8 thalassemia-beta, dominant inclusion-body 10.2 EPO HBA2
9 mental retardation, autosomal recessive 59 10.2 TUBB2B TUBB3
10 tjp2-related familial hypercholanemia 10.2 EPO HBA2 KLF1
11 endometrial adenocarcinoma 10.1 EPO HBA2 KLF1
12 adult malignant mesenchymoma 10.1 EPO HBA2 KLF1
13 albinism, oculocutaneous, type ia 10.1 EPO SERPINH1
14 abducens nerve disease 10.1 TUBB2B TUBB3
15 microcephaly-micromelia syndrome 10.1 TUBB2B TUBB3
16 erythropoietin polycythemia 10.0 EPO EPOR
17 atrioventricular septal defect 2 10.0 EPO EPOR
18 methemoglobinemia 10.0 EPO EPOR
19 angiodysplasia 10.0 TUBB2B TUBB3
20 exertional headache 10.0 EPO EPOR
21 cerebellar hypoplasia and mental retardation with or without quadrupedal locomotion 1 10.0 EPO EPOR
22 dic in newborn 10.0 EPO EPOR
23 inflammatory leiomyosarcoma 9.8 EPO EPOR
24 nelson syndrome 9.7 EPO EPOR
25 dilated cardiomyopathy 9.6 EPO EPOR KLF1
26 thrombocythemia 3 9.6 EPO EPOR
27 thalassemia 9.5
28 thrombocytopenia 9.5
29 anemia of prematurity 9.5
30 cerebritis 9.5
31 choriocarcinoma 9.5
32 hydrops fetalis 9.5
33 hemochromatosis 9.5
34 diamond-blackfan anemia 9.5
35 hemolytic anemia 9.5
36 afferent loop syndrome 9.4 EPO EPOR
37 acute leukemia 9.3 EPO EPOR HBA2 KLF1
38 disseminated intravascular coagulation 6.8 ACCS CMC2 EPO EPOR HBA2 KLF1

Graphical network of the top 20 diseases related to Neonatal Anemia:



Diseases related to Neonatal Anemia

Symptoms & Phenotypes for Neonatal Anemia

MGI Mouse Phenotypes related to Neonatal Anemia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.5 EPO EPOR HBA2 KLF1 SERPINH1 TUBB2B
2 respiratory system MP:0005388 9.02 EPO EPOR SERPINH1 TUBB2B TUBB3

Drugs & Therapeutics for Neonatal Anemia

Drugs for Neonatal Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 143)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 2,Phase 3 7439-89-6 23925
2
Copper Approved Phase 4 7440-50-8 27099
3
Hydroxocobalamin Approved Phase 4,Phase 3 13422-51-0 11953898 5460373 44475014
4
Selenium Approved, Vet_approved Phase 4,Phase 3 7782-49-2
5
Zinc Approved Phase 4 7440-66-6 32051 23994
6
Sulfamethoxazole Approved Phase 4,Phase 3 723-46-6 5329
7
Trimethoprim Approved, Vet_approved Phase 4,Phase 3 738-70-5 5578
8
Pyrimethamine Approved, Vet_approved Phase 4,Phase 3 58-14-0 4993
9
Levoleucovorin Approved Phase 4 68538-85-2
10
Spiramycin Approved Phase 4 24916-50-5
11
Sulfadiazine Approved, Vet_approved Phase 4 68-35-9 5215
12
Desogestrel Approved Phase 4 54024-22-5 40973
13
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
14
Cyanocobalamin Approved, Nutraceutical Phase 4,Phase 3 68-19-9 44176380
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
16
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 1 58-05-9 143 6006
17
Niacin Approved, Investigational, Nutraceutical Phase 4,Phase 3 59-67-6 938
18
Nicotinamide Approved, Nutraceutical Phase 4,Phase 3 98-92-0 936
19
Pyridoxal Approved, Nutraceutical Phase 4 66-72-8 1050
20
Pyridoxine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 65-23-6 1054
21
Riboflavin Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 83-88-5 493570
22
Thiamine Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 59-43-8 1130
23 Tocopherol Approved, Nutraceutical Phase 4
24
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 11103-57-4, 68-26-8 445354
25
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
26
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
27
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
28
Iodine Investigational Phase 4,Phase 3 7553-56-2 807
29 Antioxidants Phase 4,Phase 2,Phase 1
30
Bilirubin Phase 4 635-65-4 5280352
31 Pharmaceutical Solutions Phase 4
32 Protective Agents Phase 4,Phase 2,Phase 1
33 Micronutrients Phase 4,Phase 3,Phase 2
34 Trace Elements Phase 4,Phase 3,Phase 2
35 Hematinics Phase 4,Phase 2,Phase 3,Phase 1
36 Anti-Infective Agents Phase 4,Phase 3,Phase 1
37 Antiparasitic Agents Phase 4,Phase 3,Phase 1
38 Antibodies Phase 4
39 gamma-Globulins Phase 4
40 Immunoglobulins Phase 4
41 Immunoglobulins, Intravenous Phase 4
42 Rho(D) Immune Globulin Phase 4
43 cadexomer iodine Phase 4,Phase 3
44 Nicotinic Acids Phase 4,Phase 3
45 Retinol palmitate Phase 4,Phase 2
46 Tocopherols Phase 4
47 Tocotrienols Phase 4
48 Vitamin B 12 Phase 4,Phase 3
49 Vitamin B 6 Phase 4,Phase 3
50 Vitamin B Complex Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 87)

id Name Status NCT ID Phase Drugs
1 Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency Unknown status NCT02594904 Phase 4 Yinzhihuang Oral Liquid
2 Iron Supplementation of Marginally Low Birth Weight Infants Unknown status NCT00558454 Phase 4 Iron
3 Effectiveness of Adaptation of the Dose of Iron Supplementation in Pregnancy on Maternal-child Health. (ECLIPSES) Completed NCT03196882 Phase 4 40mg/day of iron;20mg/day of iron;80mg/day of iron
4 Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic Disease Completed NCT00288600 Phase 4 Intravenous Immunoglobulin;Normal saline solution
5 Prevention of Intrauterine Growth Retardation in Hounde District, Burkina Faso Completed NCT00642408 Phase 4
6 Safety of Cotrimoxazole in HIV- and HAART-exposed Infants Completed NCT01086878 Phase 4 cotrimoxazole
7 Resistance Exercise Training During Pregnancy: a Randomized Controlled Trial Completed NCT00813657 Phase 4
8 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4 ferric carboxymaltose
9 Randomized Controlled Trial Comparing a Conservative Management and Laser Surgery Recruiting NCT01220011 Phase 4
10 Supplementing Iron and Development in Breastfed Infants (SIDBI Study) Recruiting NCT02242188 Phase 4 Iron
11 Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis Recruiting NCT00004317 Phase 4 Leucovorin calcium;Pyrimethamine;Spiramycin;Sulfadiazine
12 Contraception in Women With Sickle Cell Disease Active, not recruiting NCT02594462 Phase 4 etonogestrel-releasing implant contraceptive
13 Treatment and Prevention of Severe Anemia in Pregnant Zanzibari Women Unknown status NCT00148629 Phase 3 multivitamin, mebendazole
14 A Trial Evaluating the Role of Sildenafil in the Treatment of Fetal Growth Restriction Completed NCT02590536 Phase 3 Sildenafil citrate;placebo
15 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
16 The Effects of Erythropoietin (EPO) on the Transfusion Requirements of Very Low Birth Weight Infants Completed NCT01203514 Phase 2, Phase 3 Erythropoietin
17 a Randomized Multicenter Trial Comparing Vacuum Assisted Delivery With the New Device "iCUP" Versus the Reference Cup. Completed NCT01058200 Phase 3
18 Establishing Effectiveness of Daily Co-trimoxazole Prophylaxis For Prevention of Malaria in Pregnancy Completed NCT01053325 Phase 3 Cotrimoxazole prophylaxis;SP IPT
19 Impact of Prenatal Vitamin/Mineral Supplements on Perinatal Mortality Completed NCT00133744 Phase 3
20 Transfusion of Prematures Trial Active, not recruiting NCT01702805 Phase 3
21 EPO-4-Rhesus: Role of Darbepoetin Alfa in Reducing Late Anaemia in Neonates With Red Blood Cell Alloimmunization After Intrauterine Transfusions Not yet recruiting NCT03104426 Phase 2, Phase 3 Darbepoetin Alfa
22 Daily Co-trimoxazole Prophylaxis to Prevent Malaria in Pregnancy Terminated NCT00711906 Phase 3 Cotrimoxazole;Sulfadoxine-pyrimethamine
23 Immediate VS Delayed Cord Clamping on Newborns Unknown status NCT01029496 Phase 1, Phase 2
24 Darbepoetin Administration to Preterm Infants Unknown status NCT00334737 Phase 2 darbepoetin alfa;erythropoietin;sham injection
25 Milking the Umbilical Cord Versus Immediate Clamping in Pre-term Infants < 33 Weeks Unknown status NCT01819532 Phase 2
26 Red Blood Cell (RBC) Survival Following Transfusion in Infants Completed NCT00731588 Phase 2
27 Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants Completed NCT01081977 Phase 2
28 Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy Completed NCT00808704 Phase 1, Phase 2 recombinant human erythropoietin
29 Optimized Erythropoietin (EPO) Treatment Recruiting NCT02075970 Phase 2 Epoetin Alpha;Biotinylated Red Blood Cells
30 Safety Study of Cord Blood Units for Stem Cell Transplants Recruiting NCT01861093 Phase 2
31 Single-dose Postpartum Vitamin A Supplementation of Mothers and Neonates Active, not recruiting NCT00198718 Phase 2 Vitamin A (retinyl palmitate)
32 Realizing Effectiveness Across Continents With Hydroxyurea (REACH) Active, not recruiting NCT01966731 Phase 1, Phase 2 Hydroxyurea
33 Prevention of Transfusion Related Acute Gut Injury (TRAGI) in Extremely Low Gestational Age Neonates (ELGANs) Using iNO Not yet recruiting NCT02851472 Phase 1, Phase 2 Inhaled Nitric Oxide;Placebo
34 High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study Terminated NCT00589953 Phase 2 Erythropoietin;Saline placebo
35 Autologous Cord Blood Infusion for the Prevention and Treatment of Prematurity Complications In Preterm Neonates Unknown status NCT02050971 Phase 1
36 Autologous Umbilical Cord Blood Transfusion for Preterm Neonates Unknown status NCT01121328 Phase 1
37 Chlorproguanil-Dapsone in Pregnant Women Suspended NCT00126971 Phase 1 chlorproguanil-dapsone
38 Study on Newborn Babies With a Yellow Skin Color (Neonatal Jaundice Study) Unknown status NCT02361788
39 Risk Factors for Severe Morbidity and Mortality in Mothers and Neonates Unknown status NCT01757028
40 Research Network for Neonatal Diseases Induced by Tissular Fetomaternal Alloimmunization Unknown status NCT00199628
41 Delayed Umbilical Cord Clamping in Infants Less Than 32 Weeks Unknown status NCT00562536
42 Milking Versus Delayed Cord Clamping in Full Term Neonates Completed NCT02454101
43 Identification of Early Predictors of Fetomaternal Hemorrhage Completed NCT01232387
44 Measurements of Anemia and Physiologic Tissue Response to Blood Transfusions in VLBW Infants Using Quantitative NIRS Completed NCT00544375
45 Impact of Maternal Iron Status on Neonatal Iron Status and Auditory Brainstem Response in the Newborn Completed NCT01019902
46 Effect of Maternal Hemoglobin on Neurobehavioural Development of Late Preterm Neonates : A Cohort Study Completed NCT02840292
47 Splanchnic Tissue Oxygenation During Enteral Feedings in Anemic Premature Infants at Risk for Necrotizing Enterocolitis Completed NCT01735578
48 Hepcidin Levels in Preterm Infants Completed NCT01539356
49 Post Partum Maternal and Neonatal Intervention Package Completed NCT01389219
50 Newborn Vitamin A (VA) Supplementation Pilot Project, Pakistan Completed NCT00674089

Search NIH Clinical Center for Neonatal Anemia

Cochrane evidence based reviews: anemia, neonatal

Genetic Tests for Neonatal Anemia

Anatomical Context for Neonatal Anemia

MalaCards organs/tissues related to Neonatal Anemia:

39
Heart, Testes, Neutrophil, Bone, Skin, Endothelial, Brain

Publications for Neonatal Anemia

Articles related to Neonatal Anemia:

(show all 50)
id Title Authors Year
1
Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development. ( 28143845 )
2017
2
Neonatal anemia: Revisiting the enigmatic pyknocyte. ( 28335086 )
2017
3
Management and prevention of neonatal anemia: current evidence and guidelines. ( 24524256 )
2014
4
A novel epsilon gamma delta beta thalassemia presenting with pregnancy complications and severe neonatal anemia. ( 23206178 )
2013
5
Imaging diagnosis of neonatal anemia: report of two unusual etiologies. ( 24605254 )
2013
6
A mathematical modeling approach to quantify the role of phlebotomy losses and need for transfusions in neonatal anemia. ( 23033916 )
2013
7
Severe neonatal anemia from fetomaternal hemorrhage: report from a multihospital health-care system. ( 23196720 )
2013
8
Doppler middle cerebral artery peak systolic velocity for diagnosis of neonatal anemia. ( 22922618 )
2012
9
Clinical and research issues in neonatal anemia and thrombocytopenia. ( 22227780 )
2012
10
Nonpharmacological, blood conservation techniques for preventing neonatal anemia--effective and promising strategies for reducing transfusion. ( 22818543 )
2012
11
Fetal and neonatal anemia associated with anti-Jr(a) : a case report showing a poorly hemolytic mechanism. ( 21481087 )
2011
12
Risk factors of neonatal anemia in placenta previa. ( 21960747 )
2011
13
Intrahepatic and adrenal hemorrhage as a rare cause of neonatal anemia. ( 21388342 )
2011
14
Infantile pyknocytosis: a rare form of neonatal anemia. ( 20684190 )
2010
15
Erythropoietin pharmacokinetic/pharmacodynamic analysis suggests higher doses in treating neonatal anemia. ( 19371274 )
2009
16
Hematologic characterization and chromosomal localization of the novel dominantly inherited mouse hemolytic anemia, neonatal anemia (Nan). ( 19409822 )
2009
17
Neonatal anemia. ( 18411074 )
2008
18
Treatment and Prevention of Neonatal Anemia. ( 20209037 )
2008
19
Assessment of neonatal anemia. ( 17453046 )
2007
20
Neonatal anemia and hydrops fetalis after maternal mycophenolate mofetil use. ( 17180133 )
2007
21
Neonatal anemia associated with Southeast Asian ovalocytosis. ( 16207591 )
2005
22
Profound early-onset neonatal anemia: a case study. ( 12943209 )
2002
23
Hb Dartmouth [alpha66(E15)Leu-->Pro (alpha2) (CTG-->CCG)]: a novel alpha2-globin gene mutation associated with severe neonatal anemia when inherited in trans with Southeast Asian alpha-thalassemia-1. ( 11791870 )
2001
24
[Neonatal anemia and Rhesus incompatibility: is there a place for erythropoietin?]. ( 11147059 )
2000
25
[Recombinant erythropoietin and early preterm neonatal anemia]. ( 10476641 )
1999
26
Management of severe neonatal anemia due to fetomaternal transfusion. ( 10458533 )
1999
27
[Prevention of neonatal anemia with recombinant human erythropoietin: a cost-benefit analysis]. ( 10612190 )
1999
28
The nonreactive nonstress test: predictive value for neonatal anemia in the isoimmunized pregnancy. ( 8752240 )
1996
29
Neonatal anemia: pathophysiology and treatment. ( 7713595 )
1995
30
Erythropoietin in the pathogenesis and treatment of neonatal anemia. ( 7998075 )
1995
31
Recombinant human erythropoietin in neonatal anemia. ( 8521685 )
1995
32
Erythropoietin and neonatal anemia. ( 8139633 )
1994
33
Unusual clinical features of neonatal anemia due to fetomaternal transfusion. ( 8333290 )
1993
34
The changing pattern of maternal and neonatal anemia at Udaipur during 2 decades in relation to poverty, parity, prematurity and vegetarianism. ( 2064586 )
1991
35
Fetal hemoglobin in neonatal anemia. ( 1702888 )
1991
36
Management of neonatal anemia in the delivery room. ( 2094675 )
1990
37
Evaluation of a new method for the prevention of neonatal anemia. ( 2704595 )
1989
38
Nuchal cord as a cause of neonatal anemia. ( 4036898 )
1985
39
Nuchal cord as a cause of neonatal anemia. ( 3969987 )
1985
40
Severe neonatal anemia possibly caused by spontaneous cephalic version, with excellent outcome--a case report. ( 6502441 )
1984
41
Choriocarcinoma with neonatal anemia. ( 584929 )
1977
42
Severe neonatal anemia due to massive transplacental hemorrhage. ( 6021546 )
1967
43
Relation of time of ligation of umbilical cord to neonatal anemia. ( 5183183 )
1967
44
Congenital neonatal anemia in Hanford miniature swine. BNWL-280. ( 5301031 )
1966
45
Relation of maternal fetal hemoglobin and bilirubin to neonatal anemia, type of delivery, and outcome of pregnancy. ( 13977769 )
1963
46
Neonatal anemia due to water-soluble vitamin K analogue: case report. ( 13712478 )
1961
47
Neonatal anemia due to transplacental blood loss; a case report. ( 13661246 )
1959
48
Fetal-maternal transfusion with consequent neonatal anemia; report of a case. ( 13661109 )
1959
49
Neonatal anemia due to fetal hemorrhage into the maternal circulation. ( 13441371 )
1957
50
Prevention of neonatal anemia in the rat by the pituitary erythropoietic factor. ( 13230163 )
1955

Variations for Neonatal Anemia

Expression for Neonatal Anemia

Search GEO for disease gene expression data for Neonatal Anemia.

Pathways for Neonatal Anemia

Pathways related to Neonatal Anemia according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.84 EPO KLF1
2
Show member pathways
10.6 EPO EPOR
3 10.05 EPO EPOR

GO Terms for Neonatal Anemia

Biological processes related to Neonatal Anemia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 erythrocyte differentiation GO:0030218 9.16 EPO KLF1
2 microtubule-based process GO:0007017 8.96 TUBB2B TUBB3
3 erythropoietin-mediated signaling pathway GO:0038162 8.62 EPO EPOR

Sources for Neonatal Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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