Neonatal Diabetes Mellitus malady

Wikipedia: Neonatal diabetes mellitus (NDM) is a monogenic form of diabetes that occurs in the first 6 months of...⁴⁴ more...

MalaCards: Neonatal Diabetes Mellitus, also known as diabetes mellitus syndrome in newborn infant, is related to type 2 diabetes mellitus and gestational diabetes. An important gene associated with Neonatal Diabetes Mellitus is KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11), and among its related pathways are Antiarrhythmic Pathway, Pharmacodynamics and Inwardly rectifying K+ channels. The drug chromium picolinate and the compounds cibenzoline and meglitinide have been mentioned in the context of this disorder. Affiliated tissues include kidney, pancreas and t cells, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Descriptions:

neonatal diabetes mellitus 6 8 32 43 diabetes mellitus syndrome in newborn infant 6

diabetes mellitus 43

Diseases related to neonatal diabetes mellitus by text searches and GeneDecks gene sharing:

(show top 50)    (show all 403)

id	Related Disease	Score	Top Affiliating Genes
1	type 2 diabetes mellitus	42.1	KCNJ11, TCF7L2
2	gestational diabetes	37.2	KCNJ11, INS, ABCC8, GCK, TCF7L2
3	permanent neonatal diabetes mellitus	36.1	GCK, ABCC8, INS
4	diabetes mellitus, 6q24-related transient neonatal	35.5	PLAGL1, HYMAI
5	insulin resistance	35.5	HNF1B, IGF1, INS, PDX1, ABCC8, TCF7L2
6	hypertension	34.9	KCNJ11, GCK, F2, KCNJ5, INS, TPO
7	nephropathy	34.3	FOXP3, KCNJ11, TCF7L2, INS, IGF1, HNF1B
8	obesity	33.9	PDX1, KCNJ5, INS, IGF1, HNF1B, ABCC8
9	coronary heart disease	33.0	F2, INS, IGF1, KCNJ5, TCF7L2, KCNJ11
10	hypoglycemia	32.8	PDX1, IGF1, INS, KCNJ5, KCNJ11, GCK
11	homocysteine	32.7	F2, GCK, INS, IGF1, SLC2A2
12	transient neonatal diabetes mellitus	32.6	TNDM, TPO, HYMAI, IGF1, INS, KCNJ11
13	atherosclerosis	32.5	GCK, TCF7L2, F2, INS, IGF1, TPO
14	autoimmune thyroiditis	32.0	FOXP3, TPO, SLC2A2, INS
15	hyperlipidemia	32.0	GCK, INS, IGF1, F2
16	pancreatic agenesis	31.7	INS, ABCC8, GCK, KCNJ11, PDX1
17	celiac disease	31.7	TPO, F2, IGF1, INS, FOXP3, KCNJ11
18	myocardial infarction	31.5	KCNJ5, ZACN, INS, IGF1, F2, TPO
19	essential hypertension	31.4	F2, IGF1, INS, GCK, KCNJ11, KCNJ5
20	hyperglycemia	31.2	SLC2A2, TPO, HNF1B, IGF1, KCNJ11, PDX1
21	hypercholesterolemia	31.1	PDX1, F2, IGF1, INS
22	diabetes mellitus, noninsulin-dependent	31.0	HNF1B, ABCC8, SLC2A2
23	ischemic heart disease	31.0	IGF1, F2, KCNJ5, INS
24	cholesterol	31.0	TPO, ABCC8, F2, HNF1B, GCK, INS
25	thyroiditis	30.8	TPO, HNF1B, F2, IGF1, INS, FOXP3
26	diabetes, type 2	30.6	ABCC8, KCNJ11, INS, TCF7L2
27	ischemia	30.4	F2, IGF1, ABCC8, INS, KCNJ11, GCK
28	diabetes insipidus	30.1	TPO, IGF1, INS
29	glucose intolerance	30.0	GCK, TCF7L2, ABCC8, TPO, IGF1, PDX1
30	rabson-mendenhall syndrome	29.9	INS, IGF1
31	fanconi-bickel syndrome	29.5	SLC2A2, F2, ABCC8
32	acute myocardial infarction	29.5	INS, TPO, F2, IGF1, KCNJ11, KCNJ5
33	hypoparathyroidism	29.4	INS, IGF1, TPO
34	cerebritis	29.4	GCK, IGF1, PDX1, F2, ABCC8, INS
35	morbid obesity	29.3	ABCC8, SLC2A2, INS, F2, IGF1
36	cystic fibrosis	29.1	IGF1, ABCC8, F2, TCF7L2, INS, KCNJ11
37	hyperinsulinism	29.1	GCK, SLC2A2, ABCC8, IGF1, INS, KCNJ5
38	polycystic ovary syndrome	29.1	INS, KCNJ11, F2, TCF7L2, IGF1, TPO
39	congenital hypothyroidism	29.0	IGF1, GLIS3, TPO
40	hyperinsulinemic hypoglycemia	28.8	ABCC8, INS
41	insulinoma	28.7	ABCC8, GCK, KCNJ11, KCNJ5, INS, PDX1
42	hepatitis	28.6	GCK, FOXP3, INS, IGF1, F2, GLIS3
43	type 1 diabetes mellitus	28.5	TPO, IGF1, INS, FOXP3, GCK
44	fetal macrosomia	28.4	INS, IGF1
45	arterial calcification	28.4	KCNJ11, INS, TCF7L2
46	twinning	27.8	HNF1B, GCK, FOXP3, F2, IGF1, TCF7L2
47	diabetes mellitus	27.8	KCNJ11, ZFP57, GCK, ZNF673, ZACN, IGF1
48	alcoholic liver cirrhosis	27.7	INS, IGF1, F2
49	hypothyroidism	27.6	GLIS3, IGF1, GCK, INS, F2, TPO
50	paralysis	27.5	TPO, F2, INS, KCNJ5

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 chromium picolinate

MalaCards organs/tissues related to neonatal diabetes mellitus:

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MGI Mouse Phenotypes related to neonatal diabetes mellitus:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.9	KCNJ11, PTF1A, ABCC8
2	integument phenotype	MP:0010771	8.7	PDX1, PLAGL1, F2, FOXP3, KCNJ11
3	liver/biliary system phenotype	MP:0005370	8.1	PDX1, ONECUT1, PTF1A, HNF1B, INS, FOXP3
4	digestive/alimentary phenotype	MP:0005381	7.3	PDX1, ONECUT1, PTF1A, F2, INS, FOXP3
5	cardiovascular system phenotype	MP:0005385	7.1	PLAGL1, ONECUT1, PTF1A, F2, IGF1, INS
6	growth/size phenotype	MP:0005378	6.7	SLC2A2, PDX1, PLAGL1, ONECUT1, PTF1A, TPO
7	mortality/aging	MP:0010768	6.3	PTF1A, ONECUT1, PLAGL1, PDX1, SLC2A2, TPO
8	homeostasis/metabolism phenotype	MP:0005376	4.6	TPO, PTF1A, ONECUT1, PDX1, ABCC8, TCF7L2

Articles related to neonatal diabetes mellitus:

(show all 49)

id	Title	Authors	Year	Affiliating Genes
1	KCNJ11 activating mutations cause both transient and permanent neonatal diabetes mellitus in Cypriot patients. (21352428)	Ioannou Y.S.... Skordis N.	2011	KCNJ11
2	Neonatal diabetes mellitus: description of two Puerto Rican children with KCNJ11 activating gene mutation. (21682153)	Nieves-Rivera F.... GonzA!lez-Pijem L.	2011	KCNJ11
3	A new variant of a known mutation in two siblings wit h permanent neonatal diabetes mellitus. (21823539)	Aycan Z.... Ceylaner S.	2011	INS
4	Mutations in pancreatic A9-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus. (20878480)	Hussain K.	2010	GCK
5	Neonatal diabetes mellitus with pancreatic agenesis i n an infant with homozygous IPF-1 Pro63fsX60 mutation. (19496967)	Thomas I.H.... Fajans S.S.	2009	GCK, ABCC8, KCNJ11
6	Transfer from insulin to sulfonylurea treatment in a chinese patient with permanent neonatal diabetes mellitus due to a KCNJ11 R201H mutation. (19247925)	Xiao X.... Hansen T.	2009	INS
7	Improved diabetic control during oral sulfonylurea tr eatment in two children with permanent neonatal diabetes mellitus. (19774848)	Ting W.H.... Lee Y.J.	2009	KCNJ11
8	A further example of a distinctive autosomal recessive syndrome comprising neonatal diabetes mellitus, intestinal atresias and gall bladder agenesis. (18512226)	Chappell L.... Crow Y.	2008	ONECUT1
9	Glibenclamide unresponsiveness in a Brazilian child with permanent neonatal diabetes mellitus and DEND syndrome due to a C166Y mutation in KCNJ11 (Kir6.2) gene. (19169493)	Della Manna T.... Reis A.F.	2008	KCNJ11
10	Permanent neonatal diabetes mellitus caused by a novel homozygous (T168A) glucokinase (GCK) mutation: initial response to oral sulphonylurea therapy. (18571549)	Turkkahraman D.... Gloyn A.L.	2008	GCK
11	Permanent neonatal diabetes mellitus due to a C96Y heterozygous mutation in the insulin gene. A case report. (18981553)	Ahamed A.... Edghill E.L.	2008	INS
12	Neonatal diabetes mellitus and KCNJ11 gene mutation: report of a family case (18559200)	Orio Hernandez M.... Gracia Bouthelier R.	2008	KCNJ11, INS
13	Neonatal diabetes mellitus because of pancreatic agenesis with dysmorphic features and recurrent bacterial infections. (18547237)	Taha D.... Polak M.	2008	ABCC8, KCNJ11
14	No major contribution of TCF7L2 sequence variants to maturity onset of diabetes of the young (MODY) or neonatal diabetes mellitus in French white subjects. (17093940)	Cauchi S.... Froguel P.	2007	TCF7L2
15	Neonatal diabetes mellitus: a disease linked to multiple mechanisms. (17349054)	Polak M.... CavAc H.	2007	KCNJ11
16	A mutation in the TMD0-L0 region of sulfonylurea receptor-1 (L225P) causes permanent neonatal diabetes mellitus (PNDM). (17317760)	Masia R.... Nichols C.G.	2007	ABCC8
17	Transition from insulin to glyburide in a 4-month-old girl with neonatal diabetes mellitus caused by a mutation in KCNJ11. (17659066)	Chan Y.M.... Laffel L.M.	2007	KCNJ11, INS
18	The usage of the personal insulin pump for treatment of a 7 week infant with neonatal diabetes mellitus (17239309)	Mysliwiec M.... Nazim J.	2006	INS
19	Mutations in GLIS3 are responsible for a rare syndrome with neonatal diabetes mellitus and congenital hypothyroidism. (16715098)	Senee V.... Julier C.	2006	GLIS3
20	Assessment of insulin sensitivity in adults with permanent neonatal diabetes mellitus due to mutations in the KCNJ11 gene encoding Kir6.2. (17491708)	Skupien J.... Sieradzki J.	2006	KCNJ11, INS, KCNJ5
21	Sulfonylurea treatment outweighs insulin therapy in short-term metabolic control of patients with permanent neonatal diabetes mellitus due to activating mutations of the KCNJ11 (KIR6.2) gene. (16816952)	Tonini G.... Barbetti F.	2006	KCNJ11, INS
22	Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. (16885549)	Babenko A.P.... Froguel P.	2006	ABCC8, KCNJ11, INS
23	ATP-sensitive potassium channels--neonatal diabetes mellitus and beyond. (16885555)	Sperling M.A.	2006	KCNJ5
24	The genetic basis of neonatal diabetes mellitus. (17261973)	Sperling M.A.	2006	INS, PLAGL1
25	Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach. (16873690)	Gloyn A.L.... Frayling T.M.	2006	PLAGL1, ZNF673, HYMAI
26	Neonatal diabetes mellitus. (16891687)	OzlA1 F.... YA1ksel B.	2006	INS
27	Neonatal diabetes mellitus: from understudy to center stage. (16012265)	Sperling M.A.	2005	INS
28	From gene to disease; neonatal diabetes mellitus and the KCNJ11 gene (16375017)	Slingerland A.S.... Bruining G.J.	2005	KCNJ11, INS
29	Neonatal diabetes mellitus: Insulin pump as an alternative management strategy. (16150072)	Bharucha T.... Zacharin M.	2005	INS
30	Unusual case of neonatal diabetes mellitus due to congenital pancreas agenesis. (16390394)	Ashraf A.... Moates J.M.	2005	PDX1
31	Bisulphite sequencing of the transient neonatal diabetes mellitus DMR facilitates a novel diagnostic test but reveals no methylation anomalies in patients of unknown aetiology. (15635480)	Mackay D.J.... Robinson D.O.	2005	TNDM
32	Letter Re: Neonatal diabetes mellitus and mutation in the HNF-1beta gene. (16207896)	D'Amato E.... Lorini R.	2005	HNF1B
33	Neonatal diabetes mellitus and neonatal polycystic, dysplastic kidneys: Phenotypically discordant recurrence of a mutation in the hepatocyte nuclear factor-1beta gene due to germline mosaicism. (15181075)	Yorifuji T.... Nakahata T.	2004	HNF1B
34	Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM. (15286800)	Ma D.... Kelsey G.	2004	PLAGL1, ZACN, HYMAI
35	Continuous subcutaneous insulin infusion in neonatal diabetes mellitus. (15601363)	Wintergerst K.A.... Hsiang H.Y.	2004	INS
36	Permanent neonatal diabetes mellitus manifesting as diabetic ketoacidosis. (14976569)	Lee J.H.... Hsieh W.S.	2003	INS
37	Transient neonatal diabetes mellitus, type 4, type 1 diabetes mellitus, or MODY: which disease is it, anyway? (12014522)	AvRuskin T.W.... Juan C.S.	2002	TPO
38	Identification of a novel mutation in the GLUT2 gene in a patient with Fanconi-Bickel syndrome presenting with neonatal diabetes mellitus and galactosaemia. (12029458)	Yoo H.W.... Kim G.H.	2002	F2, SLC2A2
39	Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus. (11935319)	Mackay D.J.... Robinson D.O.	2002	PLAGL1, HYMAI
40	A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus. (11448939)	Arima T.... Surani M.A.	2001	INS, PLAGL1
41	Neonatal diabetes mellitus due to complete glucokinase deficiency. (11372010)	Njoelstad P.R.... Bell G.I.	2001	GCK
42	X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. (11137992)	Wildin R.S.... Brunkow M.E.	2001	FOXP3
43	Characterization of the methylation-sensitive promoter of the imprinted ZAC gene supports its role in transient neonatal diabetes mellitus. (11297535)	Varrault A.... Journot L.	2001	PLAGL1
44	Neonatal diabetes mellitus: patient report and review of the literature. (11327380)	Sarici S.U.... Gyknay E.	2001	INS
45	HLA-DRB1 and DQB1 genotypes in patients with insulin-dependent neonatal diabetes mellitus. A study of 13 cases. (11034557)	Marquis E.... Diatloff-Zito C.	2000	INS
46	Permanent neonatal diabetes mellitus: clinical presentation and epidemiology in Oman. (10212083)	Bappal B.... Khusaiby S.M.	1999	INS
47	Neonatal diabetes mellitus with hypergalactosemia. (10526252)	Kentrup H.... Heimann G.	1999	SLC2A2
48	Ultralente insulin treatment of transient neonatal diabetes mellitus. (8636827)	Mitamura R.... Okuno A.	1996	INS
49	Transient neonatal diabetes mellitus: a relapse after 10 years of complete remission. (7949222)	Vanelli M.... Chiari G.	1994	IGF1

Genes related to neonatal diabetes mellitus according to GeneCards:

(show all 22)

id	Symbol	Description	Score	GeneCards Section Context
1	KCNJ11	potassium inwardly-rectifying channel, subfamily J, member 11	11.1	Summaries, Publications
2	PLAGL1	pleiomorphic adenoma gene-like 1	11.1	Functions, Publications, Summaries
3	TNDM	diabetes mellitus, transient neonatal	11.1	Summaries, Publications
4	HYMAI	hydatidiform mole associated and imprinted (non-protein coding)	11.1	Summaries, Publications
5	ZFP57	zinc finger protein 57 homolog (mouse)	11.1	Summaries
6	ABCC8	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	11.0	Publications
7	INS	insulin	11.0	Publications
8	PDX1	pancreatic and duodenal homeobox 1	11.0	Publications
9	GCK	glucokinase (hexokinase 4)	11.0	Publications
10	KCNJ5	potassium inwardly-rectifying channel, subfamily J, member 5	11.0	Publications
11	ZACN	zinc activated ligand-gated ion channel	11.0	Publications
12	ZNF673	zinc finger family member 673	11.0	Publications
13	SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	11.0	Publications
14	HNF1B	HNF1 homeobox B	11.0	Publications
15	TPO	thyroid peroxidase	11.0	Publications
16	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
17	PTF1A	pancreas specific transcription factor, 1a	11.0
18	ONECUT1	one cut homeobox 1	11.0	Publications
19	FOXP3	forkhead box P3	11.0	Publications
20	GLIS3	GLIS family zinc finger 3	11.0	Publications
21	TCF7L2	transcription factor 7-like 2 (T-cell specific, HMG-box)	11.0	Publications
22	F2	coagulation factor II (thrombin)	11.0	Publications

Pathways related to neonatal diabetes mellitus according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Antiarrhythmic Pathway, Pharmacodynamics34	9.8	KCNJ11, KCNJ5, ABCC8
2	Inwardly rectifying K+ channels38	9.8	KCNJ11, ABCC8
3	Potassium transporters- outward current10	9.7	KCNJ11, KCNJ5, ABCC8
4	MODY (Maturity-Onset Diabetes of Young)36	9.7	SLC2A2, INS, GCK
5	Regulation of gene expression in early pancreatic precursor cells38	9.5	PDX1, ONECUT1, PTF1A
6	Selected targets of HNF110	9.5	INS, HNF1B, PDX1, SLC2A2
7	Type II diabetes mellitus20	9.2	SLC2A2, ABCC8, PDX1, INS, KCNJ11, GCK
8	Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics34	9.0	GCK, SLC2A2, ABCC8, PDX1, HNF1B, INS
9	Maturity onset diabetes of the young20	8.9	SLC2A2, PDX1, ONECUT1, HNF1B, INS, GCK

Compounds related to neonatal diabetes mellitus according to GeneDecks:

(show all 46)

id	Compound	Score	Top Affiliating Genes
1	cibenzoline32	10.4	ABCC8, KCNJ11
2	meglitinide32	10.4	ABCC8, INS
3	benzopyran32	10.4	ABCC8, KCNJ5
4	dicyandiamide32	10.3	KCNJ5, ABCC8
5	nicorandil32	10.3	ABCC8, KCNJ5
6	chromium picolinate32	10.3	INS, GCK
7	mitiglinide32 9 9	12.3	INS, ABCC8
8	pinacidil32	10.3	KCNJ5, ABCC8
9	levosimendan32 9 9	12.3	KCNJ5, KCNJ11
10	mgadp32	10.2	ABCC8, KCNJ5, KCNJ11
11	gliclazide32 34 9 9	13.2	ABCC8, INS, KCNJ11
12	alloxan32	10.2	SLC2A2, GCK
13	Glyburide9 9	11.2	KCNJ11, KCNJ5, ABCC8
14	glipizide32 9 9	12.2	KCNJ5, INS, ABCC8
15	i-app32	10.2	GCK, INS, PDX1
16	mecasermin32 9 9	12.1	IGF1, INS
17	repaglinide32 42 9 9	13.0	ABCC8, INS, KCNJ5, KCNJ11
18	glimepiride32 34 9 9	13.0	ABCC8, INS, KCNJ5, KCNJ11
19	nateglinide32 42 9 9	13.0	ABCC8, INS, KCNJ5, KCNJ11
20	cromakalim32	10.0	KCNJ5, ABCC8
21	glibenclamide32 34	11.0	ABCC8, INS, KCNJ5, KCNJ11
22	oxandrolone32 9 9	12.0	INS, IGF1
23	chlorpropamide32 9 9	11.9	ABCC8, INS
24	aicar32 42 9 18 9	13.9	IGF1, INS, GCK
25	preproinsulin32	9.9	GCK, INS, PDX1, SLC2A2
26	incretin32	9.9	GCK, INS, PDX1, SLC2A2
27	nicotinamide32 9 9	11.9	INS, HNF1B, PDX1
28	streptozotocin32	9.9	SLC2A2, PDX1, INS, GCK
29	diazoxide32 42 9 9	12.8	ABCC8, INS, KCNJ5, KCNJ11, GCK
30	tolbutamide32 34 9 9	12.8	GCK, KCNJ11, KCNJ5, INS, ABCC8
31	octreotide32 42 9 9	12.8	PLAGL1, IGF1, INS
32	2-deoxyglucose32	9.7	SLC2A2, IGF1, INS, GCK
33	metformin32 34 9 9	12.7	GCK, KCNJ11, INS, IGF1, ABCC8
34	glucose32	9.5	SLC2A2, PDX1, ONECUT1, KCNJ5, KCNJ11
35	glutamate32	9.4	GCK, KCNJ11, KCNJ5, INS, ABCC8
36	proglucagon32	9.3	SLC2A2, TCF7L2, PDX1, GCK
37	sulfonylurea32	9.3	GCK, SLC2A2, ABCC8, PDX1, INS, KCNJ5
38	katp32	9.3	SLC2A2, ABCC8, PDX1, INS, KCNJ5, KCNJ11
39	potassium32 9 18 9	12.1	SLC2A2, ABCC8, TPO, ZACN, KCNJ5, KCNJ11
40	c-peptide32	9.0	SLC2A2, PDX1, TPO, IGF1, INS, KCNJ11
41	cholesterol32 9 18 9	12.0	ABCC8, TPO, HNF1B, IGF1, INS, GCK
42	oligonucleotide32	8.9	SLC2A2, PDX1, TPO, HNF1B, GCK, ZNF673
43	arginine32	8.7	SLC2A2, ABCC8, TPO, HNF1B, IGF1, INS
44	glycogen32 18	9.6	SLC2A2, TCF7L2, ABCC8, ONECUT1, INS, GCK
45	creatinine32	8.5	TPO, F2, IGF1, INS, GCK
46	testosterone32 9 18 9	11.4	TCF7L2, ABCC8, PLAGL1, TPO, IGF1, INS

Cellular components related to neonatal diabetes mellitus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	voltage-gated potassium channel complex	GO:008076	9.8	KCNJ11, KCNJ5, ABCC8

Biological processes related to neonatal diabetes mellitus according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	detection of glucose	GO:051594	10.2	GCK, PDX1
2	negative regulation of gluconeogenesis	GO:045721	10.1	GCK, INS
3	potassium ion transmembrane transport	GO:071805	10.1	KCNJ11, ABCC8
4	positive regulation of glycolysis	GO:045821	9.9	IGF1, INS, GCK
5	positive regulation of glycogen biosynthetic process	GO:045725	9.9	IGF1, INS, GCK
6	energy reserve metabolic process	GO:006112	9.8	SLC2A2, ABCC8, INS, KCNJ11
7	exocrine pancreas development	GO:031017	9.8	IGF1, PTF1A, PDX1
8	regulation of insulin secretion	GO:050796	9.6	SLC2A2, ABCC8, INS, KCNJ11, GCK
9	glucose transport	GO:015758	9.6	GCK, INS, SLC2A2
10	glucose metabolic process	GO:006006	9.6	PDX1, ONECUT1, INS, KCNJ11
11	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.5	F2, IGF1, INS
12	glucose homeostasis	GO:042593	9.2	GCK, INS, PDX1, TCF7L2
13	positive regulation of protein kinase B signaling cascade	GO:051897	9.1	TCF7L2, IGF1, INS
14	response to glucose stimulus	GO:009749	8.7	SLC2A2, TCF7L2, HNF1B
15	endocrine pancreas development	GO:031018	8.6	GCK, INS, HNF1B, PTF1A, ONECUT1, PDX1
16	negative regulation of transcription from RNA polymerase II promoter	GO:000122	8.3	ZFP57, GLIS3, HNF1B, PDX1, TCF7L2
17	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.2	TCF7L2, PDX1, PLAGL1, ONECUT1, HNF1B, GLIS3

Molecular functions related to neonatal diabetes mellitus according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	insulin receptor binding	GO:005158	9.3	INS, IGF1, SLC2A2
2	sequence-specific DNA binding	GO:043565	7.7	FOXP3, HNF1B, PTF1A, ONECUT1, PDX1, TCF7L2