MCID: NNT009
MIFTS: 52

Neonatal Diabetes Mellitus malady

Categories: Fetal diseases, Genetic diseases, Metabolic diseases, Rare diseases, Endocrine diseases

Aliases & Classifications for Neonatal Diabetes Mellitus

Aliases & Descriptions for Neonatal Diabetes Mellitus:

Name: Neonatal Diabetes Mellitus 12 52 14 69
Neonatal Diabetes 24 29
Diabetes Mellitus Syndrome in Newborn Infant 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11717
ICD10 33 P70.2
ICD9CM 35 775.1
NCIt 47 C99248
SNOMED-CT 64 49817004
UMLS 69 C0158981

Summaries for Neonatal Diabetes Mellitus

MalaCards based summary : Neonatal Diabetes Mellitus, also known as neonatal diabetes, is related to diabetes mellitus, transient neonatal, 1 and diabetes mellitus, permanent neonatal. An important gene associated with Neonatal Diabetes Mellitus is ABCC8 (ATP Binding Cassette Subfamily C Member 8), and among its related pathways/superpathways are Developmental Biology and Insulin secretion. The drugs Metformin and Zinc have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and pancreas, and related phenotypes are shRNA abundance <= 50% and endocrine/exocrine gland

Wikipedia : 71 Neonatal diabetes mellitus (NDM) is a monogenic form of diabetes that occurs in the first 6 months of... more...

Related Diseases for Neonatal Diabetes Mellitus

Diseases in the Neonatal Diabetes Mellitus family:

Diabetes Mellitus, Transient Neonatal, 1 Diabetes Mellitus, Transient Neonatal 2
Diabetes Mellitus, Transient Neonatal, 3 Diabetes Mellitus, 6q24-Related Transient Neonatal
Abcc8-Related Transient Neonatal Diabetes Mellitus 2 Diabetes Mellitus, Kcnj11-Related Transient Neonatal

Diseases related to Neonatal Diabetes Mellitus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
id Related Disease Score Top Affiliating Genes
1 diabetes mellitus, transient neonatal, 1 12.2
2 diabetes mellitus, permanent neonatal 12.2
3 abcc8-related transient neonatal diabetes mellitus 2 12.0
4 abcc8-related permanent neonatal diabetes mellitus 12.0
5 gck-related permanent neonatal diabetes mellitus 12.0
6 ins-related permanent neonatal diabetes mellitus 12.0
7 kcnj11-related permanent neonatal diabetes mellitus 12.0
8 pdx1-related permanent neonatal diabetes mellitus 12.0
9 diabetes mellitus, 6q24-related transient neonatal 11.8
10 diabetes mellitus, transient neonatal, 3 11.8
11 pancreatic and cerebellar agenesis 11.8
12 diabetes mellitus, neonatal, with congenital hypothyroidism 11.6
13 diabetes mellitus, transient neonatal 2 11.6
14 noonan syndrome 3 10.3 ABCC8 KCNJ11
15 diaphanospondylodysostosis 10.2 ABCC8 GCK
16 x small rings 10.2 HYMAI PLAGL1
17 nosophobia 10.2 ABCC8 GCK KCNJ11
18 ritscher-schinzel syndrome 2 10.2 ABCC8 KCNJ11
19 chondroma 10.2 ABCC8 INS KCNJ11
20 exosc3-related pontocerebellar hypoplasia 10.2 HYMAI PLAGL1 ZFP57
21 antidepressant type abuse 10.1 GCK INS KCNJ11
22 pancreatitis 10.1
23 labyrinthine unilateral reactive loss 10.1 ABCC8 GCK INS KCNJ11
24 image syndrome 10.1 INS KCNJ5
25 fanconi renotubular syndrome 2 10.1 ABCC8 PLAGL1 ZFP57
26 alopecia-mental retardation syndrome 2 10.1 ABCC8 INS SLC2A2
27 maturity-onset diabetes of the young, type 13 10.1 ABCC8 GCK INS KCNJ11
28 orbital granuloma 10.1 GCK PDX1
29 diabetic cataract 10.1 ABCC8 GCK INS KCNJ11
30 neurogenic arthropathy 10.1 ABCC8 GCK INS KCNJ11
31 hemorrhagic fever 10.1 ABCC8 KCNJ11
32 pancreatic agenesis 10.0
33 spondylocostal dysostosis 5 10.0 HNF1B SLC2A2
34 autoimmune disease 1 10.0 ABCC8 INS KCNJ11 KCNJ5
35 paroxysmal nonkinesigenic dyskinesia 2 10.0 INS NEUROD1
36 interleukin 1 receptor antagonist deficiency 10.0 EIF2AK3 KCNJ5
37 paternal uniparental disomy of chromosome 6 10.0
38 macroglossia 9.9
39 peroneal neuropathy 9.9 ABCC8 GCK INS KCNJ11 SLC2A2
40 body dysmorphic disorder 9.9 ABCC8 GCK INS KCNJ11 SLC2A2
41 deafness, autosomal recessive 66 9.9 ABCC8 HYMAI INS KCNJ11 PLAGL1 ZFP57
42 exostosis 9.9 ABCC8 GCK INS KCNJ11 KCNJ5
43 ischemic heart disease 9.9 ABCC8 GCK INS PDX1 SLC2A2
44 non-syndromic intellectual disability 9.8 ABCC8 GCK INS KCNJ11 PDX1 PTF1A
45 mosaic trisomy 13 9.8 ABCC8 GCK HNF1B INS KCNJ11 PDX1
46 brain stem glioma 9.8 ABCC8 GCK INS KCNJ11 PDX1 SLC2A2
47 congenital hypothyroidism 9.8
48 hypothyroidism 9.8
49 wolcott-rallison syndrome 9.8
50 hepatitis 9.8

Graphical network of the top 20 diseases related to Neonatal Diabetes Mellitus:



Diseases related to Neonatal Diabetes Mellitus

Symptoms & Phenotypes for Neonatal Diabetes Mellitus

GenomeRNAi Phenotypes related to Neonatal Diabetes Mellitus according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 shRNA abundance <= 50% GR00343-S 9.28 NEUROD1 PDX1 PLAGL1 PTF1A SLC2A2 EIF2AK3

MGI Mouse Phenotypes related to Neonatal Diabetes Mellitus:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.14 ABCC8 EIF2AK3 GCK GLIS3 HNF1B INS
2 growth/size/body region MP:0005378 10.11 EIF2AK3 GCK GLIS3 HNF1B INS KCNJ11
3 cellular MP:0005384 10.09 EIF2AK3 GLIS3 INS NEUROD1 PDX1 PLAGL1
4 homeostasis/metabolism MP:0005376 10.06 ABCC8 EIF2AK3 GCK GLIS3 HNF1B INS
5 mortality/aging MP:0010768 9.93 EIF2AK3 GCK GLIS3 HNF1B INS KCNJ11
6 liver/biliary system MP:0005370 9.8 INS PDX1 PTF1A SLC2A2 EIF2AK3 GCK
7 no phenotypic analysis MP:0003012 9.56 PDX1 PLAGL1 PTF1A ABCC8 EIF2AK3 GLIS3
8 renal/urinary system MP:0005367 9.1 NEUROD1 PDX1 GCK GLIS3 HNF1B INS

Drugs & Therapeutics for Neonatal Diabetes Mellitus

Drugs for Neonatal Diabetes Mellitus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 184)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4,Phase 2,Phase 3 657-24-9 14219 4091
2
Zinc Approved Phase 4,Phase 2,Phase 3 7440-66-6 32051 23994
3
Insulin Lispro Approved Phase 4 133107-64-9
4
Glyburide Approved Phase 4,Phase 3,Phase 2 10238-21-8 3488
5
Insulin Aspart Approved Phase 4,Phase 3,Phase 2 116094-23-6 16132418
6
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
7
Nevirapine Approved Phase 4 129618-40-2 4463
8
Zidovudine Approved Phase 4 30516-87-1 35370
9
Misoprostol Approved Phase 4 59122-46-2 5282381
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
11
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
12
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
13 Hematinics Phase 4
14 Micronutrients Phase 4,Phase 3,Phase 1
15 Trace Elements Phase 4,Phase 3,Phase 1
16 Vitamin B Complex Phase 4
17 Vitamins Phase 4,Phase 3,Phase 1
18 insulin Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
19 Insulin, Globin Zinc Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
20 Hypoglycemic Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
21 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
22 Antioxidants Phase 4,Phase 2,Phase 3
23 Protective Agents Phase 4,Phase 3
24 Insulin, Isophane Phase 4,Phase 3,Phase 2
25 Insulin, Short-Acting Phase 4,Phase 3,Phase 2
26 Isophane insulin, beef Phase 4,Phase 3,Phase 2
27 Isophane Insulin, Human Phase 4,Phase 3,Phase 2
28 Protamines Phase 4,Phase 3
29 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
30 Anti-Infective Agents Phase 4,Phase 2
31 Antimetabolites Phase 4,Phase 2
32 glucagon Phase 4,Phase 2,Phase 1,Early Phase 1
33 Glucagon-Like Peptide 1 Phase 4,Phase 2,Phase 1,Early Phase 1
34
Silicon Phase 4 7440-21-3 4082203
35 Sulfalene Phase 4
36 Anti-HIV Agents Phase 4
37 Anti-Retroviral Agents Phase 4
38 Antiviral Agents Phase 4
39 Cytochrome P-450 CYP3A Inducers Phase 4
40 Nucleic Acid Synthesis Inhibitors Phase 4
41 Reverse Transcriptase Inhibitors Phase 4
42 Antacids Phase 4
43 Anti-Ulcer Agents Phase 4
44 Oxytocics Phase 4
45 Folate Nutraceutical Phase 4
46 Inositol Nutraceutical Phase 4
47 Vitamin B9 Nutraceutical Phase 4
48 Acidophilus Nutraceutical Phase 4,Phase 3
49 Bifidobacterium Nutraceutical Phase 4
50
Diazoxide Approved Phase 2, Phase 3 364-98-7 3019

Interventional clinical trials:

(show top 50) (show all 291)
id Name Status NCT ID Phase
1 Efficacy of Myo-inositol in Preventing Gestational Diabetes in High-risk Pregnant Women Unknown status NCT01511835 Phase 4
2 Antioxidants in Gestational Diabetes Completed NCT02355197 Phase 4
3 Metformin Versus Insulin in Gestational Diabetes Completed NCT01240785 Phase 4
4 Treatment of Mild Gestational Diabetes With Glyburide Versus Placebo Completed NCT00744965 Phase 4
5 A Comparison Between Two Oral Hypoglycemics - Metformin and Glybenclamide for the Treatment of Gestational Diabetes Mellitus Completed NCT01563120 Phase 4
6 Resistance Exercise Training During Pregnancy: a Randomized Controlled Trial Completed NCT00813657 Phase 4
7 Lifestyle Intervention to Limit Excessive Weight Gain During Pregnancy in Minority Women Completed NCT01084941 Phase 4
8 DAME: Induction of Labor or Waiting for Suspicion Fetal Macrosomia Completed NCT00190320 Phase 4
9 Glucose Control During Labour in Gestational Diabetes Mellitus With Insulin Treatment: A Randomized Controlled Trial Recruiting NCT02590016 Phase 4
10 Effect of Probiotics (Vivomixx®) on Weight, Microbiota and Glucose Tolerance in Obese Pregnant Women and Their Newborn Recruiting NCT02508844 Phase 4
11 Study of HIV-Infected and Uninfected Pregnant Woman/Child Dyads in Gabarone, Botawana Recruiting NCT03088410 Phase 4
12 Preventing Recurrent Gestational Diabetes With Metformin Recruiting NCT02394158 Phase 4
13 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Recruiting NCT02639429 Phase 4
14 Myo-Inositol- Based Co-treatment in Women With PCOS Undergoing Assisted Reproductive Technology Recruiting NCT03177122 Phase 4
15 A Study to Confirm the Long-term Safety and Effectiveness of Kalydeco in Patients With Cystic Fibrosis Who Have an R117H-CFTR Mutation, Including Pediatric Patients Active, not recruiting NCT02722057 Phase 4
16 Long-Term Sulfonylurea Response in KCNJ11 Neonatal Diabetes Enrolling by invitation NCT02624817 Phase 4
17 Long-Term Sulfonylurea Response in ABCC8 Neonatal Diabetes (SuResponsSUR) Enrolling by invitation NCT02624830 Phase 4
18 Metabolic Analysis for Treatment Choice in Gestational Diabetes Mellitus Not yet recruiting NCT03029702 Phase 4
19 Failure Rate of GLyburide And Metformin Among Gestational Diabetics Not yet recruiting NCT03078725 Phase 4
20 Glyburide Compared to Insulin in the Management of White's Classification A2 Gestational Diabetes Withdrawn NCT00160485 Phase 4
21 Metformin Treatment in Gestational Diabetes and Noninsulin Dependent Diabetes in Pregnancy in a Developing Country Unknown status NCT01855763 Phase 2, Phase 3
22 A Randomized Clinical Trial of Oral Magnesium Supplementation in Pregnancy Unknown status NCT02032186 Phase 3
23 Diazoxide In the Management Of Hypoglycemic Neonates Unknown status NCT00994149 Phase 2, Phase 3
24 Probiotics (Lactobacillus Rhamnosus) in Reducing Glucose Intolerance During and After Pregnancy Unknown status NCT01436448 Phase 3
25 Glibentek in Patients With Neonatal Diabetes Secondary to Mutations in K+-ATP Channels Completed NCT02375828 Phase 3
26 MAIN STUDY: Low Glycaemic Index (GI) Diet in the Management of GDM SUB-STUDY: The Breast Milk Sub-Study Completed NCT01589757 Phase 2, Phase 3
27 Efficacy of Behavioral Therapy and Exercise in Gestational Diabetes Mellitus (GDM) Completed NCT01506310 Phase 3
28 Lifestyle Interventions for Expectant Mothers (LIFE-Moms Phoenix) - Phoenix Completed NCT01812694 Phase 3
29 Metformin in Obese Non-diabetic Pregnant Women Completed NCT01273584 Phase 2, Phase 3
30 Effect of Vitamin A in the Treatment of Neonatal Sepsis and Necrotizing Enterocolitis Completed NCT00707785 Phase 3
31 Effect of Physical Activity on Metabolic Syndrome in Pregnancy & Fetal Outcome Completed NCT00647595 Phase 3
32 Efficacy and Safety of Insulin Detemir Versus Neutral Protamine Hagedorn (NPH) Insulin in Pregnant Women With Type 1 Diabetes Completed NCT00474045 Phase 3
33 Diabetes Therapy to Improve BMI and Lung Function in CF Completed NCT00072904 Phase 3
34 Early Diagnosis of Diabetes Mellitus in Patients With Cystic Fibrosis Completed NCT00662714 Phase 3
35 The Microvascular Complications Study Completed NCT00222508 Phase 3
36 Insulin Glargine Vs Standard Insulin Therapy Completed NCT00222521 Phase 3
37 Behavioral Treatment of Weight Gain in CF Completed NCT00006169 Phase 3
38 Trial of Progesterone in Twins and Triplets to Prevent Preterm Birth (STTARS) Completed NCT00099164 Phase 3
39 Behavioral & Nutritional Treatment to Help CF Preschoolers Grow Completed NCT00241969 Phase 3
40 Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD) Recruiting NCT02932475 Phase 3
41 Metformin in Women With Type 2 Diabetes in Pregnancy Trial Recruiting NCT01353391 Phase 3
42 Medico-GDM Trial - Metformine to Prevent Gestational Diabetes Mellitus Recruiting NCT02275845 Phase 3
43 Modulation of the Intestinal Flora With the Probiotic VIVOMIXX™ in Pregnant Women at Risk of Metabolic Complications Recruiting NCT02768818 Phase 3
44 Cystic Fibrosis - Insulin Deficiency, Early Action Recruiting NCT01100892 Phase 3
45 A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders Recruiting NCT02336243 Phase 3
46 The Impact of Insulin Therapy on Protein Turnover in Pre-Diabetic Cystic Fibrosis Patients Recruiting NCT02496780 Phase 2, Phase 3
47 Multicenter Randomized Trial of Non-inferiority Between Glyburide and Insulin for the Treatment of Gestational Diabetes Active, not recruiting NCT01731431 Phase 3
48 Effect of a Continuous Glucose Monitoring on Maternal and Neonatal Outcomes in Gestational Diabetes Mellitus Not yet recruiting NCT02838147 Phase 3
49 A Clinical Trial of the Effectiveness of Metformin in Addition to Usual Care in the Reduction of Gestational Diabetes Mellitus Not yet recruiting NCT02980276 Phase 3
50 Glycemic Objectives of Women With Gestational Diabetes Mellitus Terminated NCT02478762 Phase 3

Search NIH Clinical Center for Neonatal Diabetes Mellitus

Genetic Tests for Neonatal Diabetes Mellitus

Genetic tests related to Neonatal Diabetes Mellitus:

id Genetic test Affiliating Genes
1 Neonatal Diabetes Mellitus 29
2 Neonatal Diabetes 24

Anatomical Context for Neonatal Diabetes Mellitus

MalaCards organs/tissues related to Neonatal Diabetes Mellitus:

39
Testes, Kidney, Pancreas, Heart, Brain

Publications for Neonatal Diabetes Mellitus

Articles related to Neonatal Diabetes Mellitus:

(show top 50) (show all 216)
id Title Authors Year
1
Case report: maternal mosaicism resulting in inheritance of a novel GATA6 mutation causing pancreatic agenesis and neonatal diabetes mellitus. ( 28049534 )
2017
2
Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise. ( 27681078 )
2016
3
Age-Adjusted Glycated Albumin at Diagnosis is more Correlated with the Product of Age and Plasma Glucose than Plasma Glucose Alone in Patients with Neonatal Diabetes Mellitus. ( 27121214 )
2016
4
Successful treatment of young infants presenting neonatal diabetes mellitus with continuous subcutaneous insulin infusion before genetic diagnosis. ( 26831749 )
2016
5
Molecular and clinical features of KATP -channel neonatal diabetes mellitus in Japan. ( 27681997 )
2016
6
Successful transition to sulfonylurea therapy in two Iraqi siblings with neonatal diabetes mellitus and iDEND syndrome due to ABCC8 mutation. ( 27849623 )
2016
7
The functional activity of hypothalamic signaling systems in rats with neonatal diabetes mellitus treated with metformin. ( 27193707 )
2016
8
Incidence, prevalence and genetic determinants of neonatal diabetes mellitus: a systematic review and meta-analysis protocol. ( 27832816 )
2016
9
Glycemic control indicator levels at diagnosis of neonatal diabetes mellitus: Comparison with other types of insulin-dependent diabetes mellitus. ( 27995726 )
2016
10
Genetic Analysis and Follow-Up of 25 Neonatal Diabetes Mellitus Patients in China. ( 26839896 )
2016
11
Differentiating Transient Idiopathic Hyperglycaemia and Neonatal Diabetes Mellitus in Preterm Infants. ( 25998132 )
2015
12
Neonatal diabetes mellitus due to a novel mutation in the GATA6 gene accompanying renal dysfunction: A case report. ( 25708516 )
2015
13
A Novel Mitochondrial DNA Deletion in a Patient with Pearson Syndrome and Neonatal Diabetes Mellitus Provides Insight into Disease Etiology, Severity and Progression. ( 26518169 )
2015
14
Sulfonylurea in the treatment of neonatal diabetes mellitus children with heterogeneous genetic backgrounds. ( 25781672 )
2015
15
Role of ZAC1 in transient neonatal diabetes mellitus and glucose metabolism. ( 26322169 )
2015
16
Successful sulfonylurea treatment in a patient with permanent neonatal diabetes mellitus with a novel KCNJ11 mutation. ( 26388896 )
2015
17
Gene Variants Associated with Transient Neonatal Diabetes Mellitus in the Very Low Birth Weight Infant. ( 26315042 )
2015
18
Age-adjusted glycated albumin accurately reflects blood glucose in patients with neonatal diabetes mellitus: comparison with calculated glycated albumin determined by past blood glucose concentrations. ( 25977574 )
2015
19
Permanent neonatal diabetes mellitus - a case report of a rare cause of diabetes mellitus in East Africa. ( 26958039 )
2015
20
Transient Neonatal Diabetes Mellitus followed by recurrent asymptomatic hypoglycaemia: a case report. ( 26631065 )
2015
21
Paediatric endocrinology: Paradigm shift in genetic testing for neonatal diabetes mellitus-new framework for clinical care. ( 26284444 )
2015
22
A novel SNP in 3' UTR of INS gene: A case report of neonatal diabetes mellitus. ( 26212367 )
2015
23
A case of a Japanese patient with neonatal diabetes mellitus caused by a novel mutation in the ABCC8 gene and successfully controlled with oral glibenclamide. ( 26568660 )
2015
24
Neonatal Hyperglycemia due to Transient Neonatal Diabetes Mellitus in Puerto Rico. ( 26576310 )
2015
25
A new compound heterozygosis for inactivating mutations in the glucokinase gene as cause of permanent neonatal diabetes mellitus (PNDM) in double-first cousins. ( 26587058 )
2015
26
Letter to the editor: recent advances in genetic testing and treatment of neonatal diabetes mellitus. ( 25559538 )
2015
27
A novel mitochondrial DNA deletion in a patient with Pearson syndrome and neonatal diabetes mellitus provides insight into disease etiology, severity and progression. ( 26016877 )
2015
28
Permanent neonatal diabetes mellitus in Jordan. ( 24825091 )
2014
29
Permanent neonatal diabetes mellitus in China. ( 25052923 )
2014
30
Deciphering a molecular mechanism of neonatal diabetes mellitus by the chemical synthesis of a protein diastereomer, [D-AlaB8]human proinsulin. ( 25002580 )
2014
31
A novel mutation of KCNJ11 gene in a patient with permanent neonatal diabetes mellitus. ( 24468099 )
2014
32
Microscopic and ultrastructural features in Wolcott-Rallison syndrome, a permanent neonatal diabetes mellitus: about two autopsy cases. ( 25131821 )
2014
33
Glycemic control indicators in patients with neonatal diabetes mellitus. ( 24748932 )
2014
34
A novel activating ABCC8 mutation underlying neonatal diabetes mellitus in an infant presenting with cerebral sinovenous thrombosis. ( 24468609 )
2014
35
Clinical utility gene card for: Transient Neonatal Diabetes Mellitus, 6q24-related. ( 24569603 )
2014
36
Permanent neonatal diabetes mellitus in monozygotic twins achieving low-dose sulfonylurea therapy. ( 23959658 )
2014
37
HbA1c can be a useful glycemic control marker for patients with neonatal diabetes mellitus older than 20 weeks of age. ( 24854496 )
2014
38
Chromosome 6q24 transient neonatal diabetes mellitus and protein sensitive hyperinsulinaemic hypoglycaemia. ( 24859512 )
2014
39
6q24 transient neonatal diabetes mellitus: the first case report from China. ( 25316252 )
2014
40
Relapsing 6q24-related transient neonatal diabetes mellitus successfully treated with a dipeptidyl peptidase-4 inhibitor: a case report. ( 24552466 )
2014
41
Permanent neonatal diabetes mellitus due to an ABCC8 mutation: a case report. ( 24618446 )
2014
42
Treatment of transient neonatal diabetes mellitus: insulin pump or insulin glargine? Our experience. ( 25437016 )
2014
43
Insulin pump therapy in transient neonatal diabetes mellitus. ( 24904869 )
2013
44
KCNJ11 in-frame 15-bp deletion leading to glibenclamide-responsive neonatal diabetes mellitus in a Chinese child. ( 24266052 )
2013
45
Genetics of neonatal diabetes mellitus. ( 23456590 )
2013
46
Age-adjusted glycated albumin: a more robust parameter to establish glycaemic control in neonatal diabetes mellitus. ( 24337793 )
2013
47
KCNJ11 in-frame 15-bp deletion leading to glibenclamide- responsive neonatal diabetes mellitus in a Chinese child. ( 23640936 )
2013
48
Transient neonatal diabetes mellitus in a Turkish patient with three novel homozygous variants in the ZFP57 gene. ( 23748067 )
2013
49
Permanent neonatal diabetes mellitus: prevalence and genetic diagnosis in the SEARCH for Diabetes in Youth Study. ( 23050777 )
2013
50
EIF2AK3 mutations in South Indian children with permanent neonatal diabetes mellitus associated with Wolcott-Rallison syndrome. ( 24168455 )
2013

Variations for Neonatal Diabetes Mellitus

ClinVar genetic disease variations for Neonatal Diabetes Mellitus:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 INS NM_000207.2(INS): c.127T> G (p.Cys43Gly) single nucleotide variant Pathogenic rs80356666 GRCh37 Chromosome 11, 2182075: 2182075
2 INS; INS-IGF2 NM_000207.2(INS): c.94G> A (p.Gly32Ser) single nucleotide variant Pathogenic rs80356664 GRCh37 Chromosome 11, 2182108: 2182108
3 ABCC8 NM_000352.4(ABCC8): c.394T> G (p.Phe132Val) single nucleotide variant Pathogenic rs80356637 GRCh37 Chromosome 11, 17491666: 17491666
4 ABCC8 NM_000352.4(ABCC8): c.3545G> A (p.Arg1182Gln) single nucleotide variant Pathogenic/Likely pathogenic rs193922400 GRCh37 Chromosome 11, 17426071: 17426071

Expression for Neonatal Diabetes Mellitus

Search GEO for disease gene expression data for Neonatal Diabetes Mellitus.

Pathways for Neonatal Diabetes Mellitus

Pathways related to Neonatal Diabetes Mellitus according to GeneCards Suite gene sharing:

(show all 12)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.21 GCK HNF1B INS NEUROD1 PDX1 PTF1A
2
Show member pathways
12.24 ABCC8 GCK INS KCNJ11 PDX1 SLC2A2
3
Show member pathways
12.1 ABCC8 INS KCNJ11 SLC2A2
4 11.93 HNF1B INS NEUROD1 PDX1 PTF1A SLC2A2
5
Show member pathways
11.86 ABCC8 KCNJ11 KCNJ5
6
Show member pathways
11.83 GCK HNF1B INS NEUROD1 PDX1 SLC2A2
7
Show member pathways
11.73 ABCC8 KCNJ11 KCNJ5
8
Show member pathways
11.5 GCK HNF1B INS NEUROD1 PDX1 PTF1A
9 11.33 ABCC8 KCNJ11 KCNJ5
10 11.28 ABCC8 GCK INS KCNJ11 PDX1 SLC2A2
11
Show member pathways
11.21 ABCC8 GCK HNF1B INS KCNJ11 NEUROD1
12 10.68 INS SLC2A2

GO Terms for Neonatal Diabetes Mellitus

Cellular components related to Neonatal Diabetes Mellitus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated potassium channel complex GO:0008076 9.13 ABCC8 KCNJ11 KCNJ5
2 ATP-sensitive potassium channel complex GO:0008282 8.62 ABCC8 KCNJ11

Biological processes related to Neonatal Diabetes Mellitus according to GeneCards Suite gene sharing:

(show all 25)
id Name GO ID Score Top Affiliating Genes
1 transcription from RNA polymerase II promoter GO:0006366 9.93 GLIS3 NEUROD1 PDX1 PLAGL1 PTF1A
2 response to drug GO:0042493 9.8 ABCC8 HNF1B KCNJ11 NEUROD1 PDX1
3 potassium ion transport GO:0006813 9.77 ABCC8 KCNJ11 KCNJ5
4 response to glucose GO:0009749 9.7 HNF1B NEUROD1 PDX1
5 glucose transport GO:0015758 9.63 GCK INS SLC2A2
6 negative regulation of insulin secretion GO:0046676 9.62 ABCC8 KCNJ11
7 pancreas development GO:0031016 9.62 PDX1 PTF1A
8 glucose homeostasis GO:0042593 9.62 GCK INS NEUROD1 PDX1
9 potassium ion import GO:0010107 9.61 KCNJ11 KCNJ5
10 positive regulation of protein localization to nucleus GO:1900182 9.61 EIF2AK3 INS
11 nitric oxide mediated signal transduction GO:0007263 9.58 NEUROD1 PDX1
12 cellular glucose homeostasis GO:0001678 9.58 ABCC8 GCK
13 positive regulation of glycogen biosynthetic process GO:0045725 9.57 GCK INS
14 negative regulation of gluconeogenesis GO:0045721 9.56 GCK INS
15 endocrine pancreas development GO:0031018 9.54 EIF2AK3 NEUROD1 PDX1
16 negative regulation of type B pancreatic cell apoptotic process GO:2000675 9.51 NEUROD1 PDX1
17 exocrine pancreas development GO:0031017 9.49 PDX1 PTF1A
18 amacrine cell differentiation GO:0035881 9.48 NEUROD1 PTF1A
19 glucose metabolic process GO:0006006 9.46 GCK INS KCNJ11 PDX1
20 detection of glucose GO:0051594 9.43 GCK PDX1
21 hindbrain development GO:0030902 9.43 HNF1B NEUROD1 PTF1A
22 insulin secretion GO:0030073 9.26 EIF2AK3 HNF1B NEUROD1 PDX1
23 regulation of insulin secretion GO:0050796 9.02 ABCC8 GCK KCNJ11 NEUROD1 SLC2A2
24 regulation of transcription, DNA-templated GO:0006355 10.19 GLIS3 HNF1B INS NEUROD1 PDX1 PLAGL1
25 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.02 GLIS3 HNF1B NEUROD1 PDX1 PLAGL1 PTF1A

Molecular functions related to Neonatal Diabetes Mellitus according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.7 GLIS3 HNF1B NEUROD1 PDX1 PLAGL1 PTF1A
2 inward rectifier potassium channel activity GO:0005242 8.96 KCNJ11 KCNJ5
3 ATP-activated inward rectifier potassium channel activity GO:0015272 8.62 ABCC8 KCNJ11

Sources for Neonatal Diabetes Mellitus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....