NDM
MCID: NNT009
MIFTS: 51

Neonatal Diabetes Mellitus (NDM) malady

Endocrine category

Summaries for Neonatal Diabetes Mellitus

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Neonatal diabetes mellitus (NDM) is a monogenic form of diabetes that occurs in the first 6 months of... more...

MalaCards: Neonatal Diabetes Mellitus, also known as diabetes mellitus syndrome in newborn infant, is related to permanent neonatal diabetes mellitus and diabetes mellitus, 6q24-related transient neonatal. An important gene associated with Neonatal Diabetes Mellitus is KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11), and among its related pathways are ATP sensitive Potassium channels and Antiarrhythmic Pathway, Pharmacodynamics. The compounds cibenzoline and minoxidil have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and heart, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Aliases & Classifications for Neonatal Diabetes Mellitus

Sources:
8Disease Ontology, 22GTR, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 27ICD9CM, 57SNOMED-CT, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Characteristics (Orphanet epidemiological data):

49
neonatal diabetes mellitus:
Inheritance: Autosomal dominant,Autosomal recessive,Sporadic; Age of onset: Neonatal/infancy; Age of death: Normal


Aliases & Descriptions:

neonatal diabetes mellitus 8 22 10 45 49 61
diabetes mellitus syndrome in newborn infant 8
ndm 49


External Ids:

Disease Ontology8 DOID:11717
ICD9CM27 775.1
ICD10 via Orphanet26 P70.2
SNOMED-CT57 49817004
SNOMED-CT via Orphanet58 49817004
UMLS via Orphanet62 C0158981

Related Diseases for Neonatal Diabetes Mellitus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the diabetes mellitus, 6q24-related transient neonatal family:

neonatal diabetes mellitus transient neonatal diabetes mellitus
diabetes mellitus, neonatal, with congenital hypothyroidism diabetes mellitus, transient neonatal 2
diabetes mellitus, transient neonatal, 3

Diseases related to Neonatal Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1permanent neonatal diabetes mellitus31.4GCK, INS, ABCC8
2diabetes mellitus, 6q24-related transient neonatal30.9PLAGL1, HYMAI
3pancreatic agenesis30.8PDX1
4beckwith-wiedemann syndrome30.1PLAGL1, ABCC8, ZFP57
5hyperinsulinism30.1KCNJ5, KCNJ11, GCK, IGF1, INS, ABCC8
6transient neonatal diabetes mellitus11.0
7diabetes, permanent neonatal10.9
8n syndrome10.7
9pancreatic beta cell agenesis with neonatal diabetes mellitus10.5
10macroglossia10.4
11klebsiella10.3
12diabetic ketoacidosis10.3
13congenital hypothyroidism10.3
14cerebellar agenesis10.3
15neonatal hypothyroidism10.3
16abcc8-related transient neonatal diabetes mellitus 210.3
17abcc8-related permanent neonatal diabetes mellitus10.3
18gck-related permanent neonatal diabetes mellitus10.3
19kcnj11-related permanent neonatal diabetes mellitus10.3
20pdx1-related permanent neonatal diabetes mellitus10.3
21ins-related permanent neonatal diabetes mellitus10.3
22diabetes mellitus, insulin-dependent, neonatal10.3
23klinefelter's syndrome10.1
24fanconi syndrome10.1
25hepatitis d10.1
26intestinal atresia10.1
27exocrine pancreatic insufficiency10.1
28congenital diaphragmatic hernia10.1
29thrombocytopenia10.1
30congenital hepatic fibrosis10.1
31cerebellar hypoplasia10.1
32precocious puberty10.1
33fanconi bickel syndrome10.1
34glaucoma, congenital10.1
35kid syndrome10.1
36diabetes mellitus, permanent neonatal, with cerebellar agenesis10.1
37diabetes mellitus, kcnj11-related transient neonatal10.1
38central precocious puberty10.1
39hypertriglyceridemia10.1
40sepsis10.1
41intermediate dend syndrome10.1
42calciphylaxis10.0
43nondystrophic myotonia10.0
44pancreatitis10.0INS
45morbid obesity10.0INS
46essential hypertension10.0INS
47acute myocardial infarction10.0KCNJ5
48donohue syndrome10.0INS
49turner syndrome10.0IGF1
50fetal macrosomia10.0INS

Graphical network of the top 20 diseases related to Neonatal Diabetes Mellitus:



Diseases related to neonatal diabetes mellitus

Clinical Features for Neonatal Diabetes Mellitus

Drugs & Therapeutics for Neonatal Diabetes Mellitus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Neonatal Diabetes Mellitus

Drug clinical trials:

Search ClinicalTrials for Neonatal Diabetes Mellitus

Search NIH Clinical Center for Neonatal Diabetes Mellitus

Search CenterWatch for Neonatal Diabetes Mellitus

Genetic Tests for Neonatal Diabetes Mellitus

Sources:
22GTR
See all sources

Genetic tests related to Neonatal Diabetes Mellitus:

id Genetic test Affiliating Genes
1 Neonatal Diabetes Mellitus22

Anatomical Context for Neonatal Diabetes Mellitus

Sources:
33MalaCards
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MalaCards organs/tissues related to Neonatal Diabetes Mellitus:

33
Brain, Kidney, Heart, Pancreas, Fetal brain, Pancreatic islet

Animal Models for Neonatal Diabetes Mellitus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Neonatal Diabetes Mellitus

Sources:
51PubMed
See all sources

Articles related to Neonatal Diabetes Mellitus:

(show top 50)    (show all 189)
idTitleAuthorsYear
1
Unsuccessful switch from insulin to sulfonylurea therapy in permanent neonatal diabetes mellitus due to an R201H mutation in the KCNJ11 gene: a case report. (23434183)
2013
2
Neonatal Diabetes Mellitus Due to a Novel ABCC8 Gene Mutation Mimicking an Organic Acidemia. (23783767)
2013
3
Transient neonatal diabetes mellitus in a Turkish patient with three novel homozygous variants in the ZFP57 gene. (23748067)
2013
4
Disproportionate body composition and neonatal outcome in offspring of mothers with and without gestational diabetes mellitus. (24159180)
2013
5
Neonatal diabetes mellitus in China: a case report and review of the Chinese literature. (22144719)
2012
6
Improved long-term glucose control in neonatal diabetes mellitus after early sulfonylurea allergy. (22768668)
2012
7
Permanent neonatal diabetes mellitus. (23569512)
2012
8
Maternal body mass index is a predictor of neonatal hypoglycemia in gestational diabetes mellitus. (22419709)
2012
9
Early-onset, severe lipoatrophy in a patient with permanent neonatal diabetes mellitus secondary to a recessive mutation in the INS gene. (21910811)
2012
10
Successful sulfonylurea treatment of a neonate with neonatal diabetes mellitus due to a novel missense mutation, p.P1199L, in the ABCC8 gene. (22842804)
2012
11
Transient neonatal diabetes mellitus caused by a de novoABCC8 gene mutation. (21738553)
2011
12
Intranasal administration of insulin eliminates the deficit of long-term spatial memory in rats with neonatal diabetes mellitus. (22095122)
2011
13
Treatment of transient neonatal diabetes mellitus with subcutaneous insulin glargine in an extremely low birth weight neonate. (22768014)
2011
14
Neonatal diabetes mellitus due to L233F mutation in the KCNJ11 gene. (21210267)
2011
15
KCNJ11 activating mutations cause both transient and permanent neonatal diabetes mellitus in Cypriot patients. (21352428)
2011
16
Mutations in pancreatic A9-cell Glucokinase as a cause of hyperinsulinaemic hypoglycaemia and neonatal diabetes mellitus. (20878480)
2010
17
A case of transient neonatal diabetes mellitus. (21131807)
2010
18
Neonatal hemochromatosis and Martinez-Frias syndrome of intestinal atresia and diabetes mellitus in a consanguineous newborn. (19887127)
2010
19
Partial paternal uniparental disomy of chromosome 6 in monozygotic twins with transient neonatal diabetes mellitus and macroglossia. (20412110)
2010
20
Molecular diagnosis of neonatal diabetes mellitus using next-generation sequencing of the whole exome. (21049026)
2010
21
Transient neonatal diabetes mellitus in an extremely preterm infant. (21686427)
2009
22
A Turkish newborn infant with cerebellar agenesis/neonatal diabetes mellitus and PTF1A mutation. (19650412)
2009
23
Transfer from insulin to sulfonylurea treatment in a chinese patient with permanent neonatal diabetes mellitus due to a KCNJ11 R201H mutation. (19247925)
2009
24
Compound heterozygosity for mutations in PAX6 in a patient with complex brain anomaly, neonatal diabetes mellitus, and microophthalmia. (19876904)
2009
25
Neonatal diabetes mellitus and KCNJ11 gene mutation: report of a family case]. (18559200)
2008
26
Placental mesenchymal dysplasia associated with transient neonatal diabetes mellitus and paternal UPD6. (18486206)
2008
27
Neonatal diabetes mellitus due to pancreatic agenesis. (18426328)
2008
28
A mutation in the TMD0-L0 region of sulfonylurea receptor-1 (L225P) causes permanent neonatal diabetes mellitus (PNDM). (17317760)
2007
29
Activating mutations in the ABCC8 gene in neonatal diabetes mellitus. (16885549)
2006
30
Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach. (16873690)
2006
31
Assessment of insulin sensitivity in adults with permanent neonatal diabetes mellitus due to mutations in the KCNJ11 gene encoding Kir6.2. (17491708)
2006
32
A maternal hypomethylation syndrome presenting as transient neonatal diabetes mellitus. (16816970)
2006
33
Sulfonylurea treatment outweighs insulin therapy in short-term metabolic control of patients with permanent neonatal diabetes mellitus due to activating mutations of the KCNJ11 (KIR6.2) gene. (16816952)
2006
34
Transient neonatal diabetes mellitus is associated with a recurrent (R201H) KCNJ11 (KIR6.2) mutation. (16205880)
2005
35
Neonatal diabetes mellitus, congenital hypothyroidism, hepatic fibrosis, polycystic kidneys, and congenital glaucoma: a new autosomal recessive syndrome? (12966531)
2003
36
Transient neonatal diabetes mellitus, type 4, type 1 diabetes mellitus, or MODY: which disease is it, anyway? (12014522)
2002
37
Understanding neonatal diabetes mellitus. (12378179)
2002
38
A conserved imprinting control region at the HYMAI/ZAC domain is implicated in transient neonatal diabetes mellitus. (11448939)
2001
39
Neonatal diabetes mellitus due to complete glucokinase deficiency. (11372010)
2001
40
Variable features of transient neonatal diabetes mellitus with paternal isodisomy of chromosome 6. (10757646)
2000
41
HLA-DRB1 and DQB1 genotypes in patients with insulin-dependent neonatal diabetes mellitus. A study of 13 cases. (11034557)
2000
42
Neonatal diabetes mellitus with hypergalactosemia. (10526252)
1999
43
Paternal uniparental disomy of chromosome 6 and transient neonatal diabetes mellitus. (9894800)
1998
44
Neonatal diabetes mellitus with severe hypertriglyceridemia. (8887156)
1996
45
Transient neonatal diabetes mellitus and macroglossia. (8866300)
1996
46
Neonatal diabetes mellitus associated with severe diarrhea, hyperimmunoglobulin E syndrome, and absence of islets of Langerhans. (8597835)
1995
47
Neonatal diabetes mellitus. (7769543)
1995
48
Transient neonatal diabetes mellitus. (3235149)
1988
49
Transient neonatal diabetes mellitus in sibs. (5440211)
1970
50
Transient neonatal diabetes mellitus in half sisters. (6067278)
1967

Genetic Variations for Neonatal Diabetes Mellitus

Expression for genes affiliated with Neonatal Diabetes Mellitus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Neonatal Diabetes Mellitus

Search GEO for disease gene expression data for Neonatal Diabetes Mellitus.

Pathways for genes affiliated with Neonatal Diabetes Mellitus

Sources:
54Reactome, 50PharmGKB, 12EMD Millipore, 38NCBI BioSystems Database, 30KEGG
See all sources

Compounds for genes affiliated with Neonatal Diabetes Mellitus

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Neonatal Diabetes Mellitus according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1cibenzoline4510.5KCNJ11, ABCC8
2minoxidil45 29 1112.5KCNJ5, ABCC8
3benzopyran4510.5KCNJ5, ABCC8
4dicyandiamide4510.5ABCC8, KCNJ5
5meglitinide4510.4INS, ABCC8
6chromium picolinate4510.4GCK, INS
7mitiglinide45 1111.4INS, ABCC8
8nicorandil45 2911.4ABCC8, KCNJ11, KCNJ5
9alloxan4510.4GCK, SLC2A2
10mgadp4510.4KCNJ5, KCNJ11, ABCC8
11pinacidil4510.4KCNJ5, ABCC8
12cromakalim45 2911.3ABCC8, KCNJ11, KCNJ5
13gliclazide45 50 1112.3KCNJ11, INS, ABCC8
14levosimendan45 1111.3KCNJ5, KCNJ11
15glipizide45 1111.3ABCC8, INS, KCNJ5
16i-app4510.3GCK, PDX1, INS
17Glyburide1110.3ABCC8, KCNJ11, KCNJ5
18nateglinide45 50 1112.3KCNJ5, INS, ABCC8
19proglucagon4510.3SLC2A2, PDX1, GCK
20mecasermin45 1111.2IGF1, INS
213-o-methylglucose4510.2GCK, SLC2A2
22repaglinide45 50 1112.2ABCC8, INS, KCNJ11, KCNJ5
23glimepiride45 50 1112.2KCNJ5, KCNJ11, INS, ABCC8
24glibenclamide45 29 50 6013.2KCNJ5, KCNJ11, INS, ABCC8
25aicar45 11 2412.1INS, IGF1, GCK
26preproinsulin4510.1SLC2A2, INS, PDX1, GCK
27incretin4510.1GCK, PDX1, INS, SLC2A2
28chlorpropamide45 1111.1INS, ABCC8
29nicotinamide45 1111.1INS, PDX1, HNF1B
30tertiapin-q6010.1KCNJ11, KCNJ5
31oxandrolone45 1111.1INS, IGF1
32streptozotocin4510.1GCK, PDX1, INS, SLC2A2
332-deoxyglucose45 1111.0SLC2A2, INS, IGF1, GCK
34diazoxide45 60 29 1113.0KCNJ5, KCNJ11, GCK, INS, ABCC8
35tolbutamide45 50 29 1113.0KCNJ5, KCNJ11, GCK, INS, ABCC8
36octreotide45 60 29 1113.0PLAGL1, INS, IGF1
37metformin45 50 1111.9KCNJ11, GCK, IGF1, INS, ABCC8
38uric acid45 2410.7TPO, INS, HNF1B
39glycogen45 2410.6GCK, INS, ABCC8, SLC2A2, ONECUT1
40sulfonylurea459.6SLC2A2, KCNJ5, KCNJ11, GCK, PDX1, INS
41katp459.6KCNJ5, KCNJ11, GCK, PDX1, INS, ABCC8
42testosterone45 60 11 2412.6KCNJ5, IGF1, INS, ABCC8, PLAGL1, TPO
43cholesterol45 29 11 2412.5GCK, HNF1B, IGF1, INS, ABCC8, TPO
44potassium45 11 2411.5KCNJ5, KCNJ11, GCK, ZACN, ABCC8, SLC2A2
45c-peptide459.5KCNJ11, GCK, PDX1, IGF1, INS, SLC2A2
46glutamate459.5KCNJ5, KCNJ11, GCK, INS, ABCC8, TPO
47oligonucleotide459.3GCK, HNF1B, PDX1, SLC2A2, KRBOX4, TPO
48arginine459.2KCNJ11, GCK, HNF1B, IGF1, INS, ABCC8
49atp45 2910.0KCNJ5, KCNJ11, GCK, ABCC8, SLC2A2, TPO
50glucose458.4KLF11, KCNJ5, KCNJ11, GCK, HNF1B, PDX1

GO Terms for genes affiliated with Neonatal Diabetes Mellitus

Sources:
16Gene Ontology
See all sources

Cellular components related to Neonatal Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated potassium channel complexGO:0080769.9ABCC8, KCNJ11, KCNJ5

Biological processes related to Neonatal Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1detection of glucoseGO:05159410.2PDX1, GCK
2positive regulation of glycolysisGO:04582110.1GCK, IGF1, INS
3positive regulation of glycogen biosynthetic processGO:04572510.1INS, IGF1, GCK
4exocrine pancreas developmentGO:03101710.0PTF1A, IGF1, PDX1
5negative regulation of gluconeogenesisGO:04572110.0GCK, INS
6hindbrain developmentGO:03090210.0PTF1A, HNF1B
7energy reserve metabolic processGO:0061129.9KCNJ11, INS, ABCC8, SLC2A2
8glucose transportGO:0157589.9SLC2A2, INS, GCK
9regulation of insulin secretionGO:0507969.8KCNJ11, GCK, INS, ABCC8, SLC2A2
10glucose metabolic processGO:0060069.7KCNJ11, PDX1, INS, ONECUT1
11glucose homeostasisGO:0425939.6INS, PDX1, GCK
12endocrine pancreas developmentGO:0310189.1ONECUT1, PTF1A, SLC2A2, INS, PDX1, HNF1B
13positive regulation of transcription from RNA polymerase II promoterGO:0459449.0HNF1B, PDX1, FOXP3, IGF1, PLAGL1, ONECUT1

Molecular functions related to Neonatal Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.0INS, IGF1

Products for genes affiliated with Neonatal Diabetes Mellitus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neonatal Diabetes Mellitus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet