NDM
MCID: NNT009
MIFTS: 54

Neonatal Diabetes Mellitus (NDM) malady

Endocrine diseases category

Summaries for Neonatal Diabetes Mellitus

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63Wikipedia, 32MalaCards
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Wikipedia:63 Neonatal diabetes mellitus (NDM) is a monogenic form of diabetes that occurs in the first 6 months of... more...

MalaCards: Neonatal Diabetes Mellitus, also known as diabetes mellitus syndrome in newborn infant, is related to diabetes mellitus and permanent neonatal diabetes mellitus. An important gene associated with Neonatal Diabetes Mellitus is KCNJ11 (potassium inwardly-rectifying channel, subfamily J, member 11), and among its related pathways are ATP sensitive Potassium channels and Inwardly rectifying K+ channels. The compounds cibenzoline and minoxidil have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and pancreas, and related mouse phenotypes are renal/urinary system and no phenotypic analysis.

Aliases & Classifications for Neonatal Diabetes Mellitus

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Sources:
8Disease Ontology, 22GTR, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 27ICD9CM, 56SNOMED-CT, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
neonatal diabetes mellitus:
Inheritance: Autosomal dominant,Autosomal recessive,Sporadic; Age of onset: Neonatal/infancy; Age of death: Normal


Aliases & Descriptions:

neonatal diabetes mellitus 8 22 10 44 48 60
diabetes mellitus syndrome in newborn infant 8
ndm 48


External Ids:

Disease Ontology8 DOID:11717
ICD9CM27 775.1
ICD10 via Orphanet26 P70.2
SNOMED-CT56 49817004
SNOMED-CT via Orphanet57 49817004
UMLS via Orphanet61 C0158981

Related Diseases for Neonatal Diabetes Mellitus

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Diabetes Mellitus, 6q24-Related Transient Neonatal family:

neonatal diabetes mellitus Transient Neonatal Diabetes Mellitus
Diabetes Mellitus, Kcnj11-Related Transient Neonatal Abcc8-Related Transient Neonatal Diabetes Mellitus 2
Diabetes Mellitus, Transient Neonatal 2 Diabetes Mellitus, Transient Neonatal, 3

Diseases related to Neonatal Diabetes Mellitus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes mellitus31.8KCNJ11, FOXP3, KCNJ5, HNF1B, PDX1, IGF1
2permanent neonatal diabetes mellitus31.4KCNJ11, INS, ABCC8
3diabetes mellitus, 6q24-related transient neonatal31.0PLAGL1, HYMAI
4pancreatitis30.8INS
5hypothyroidism30.3TPO, INS, IGF1
6pancreatic agenesis30.1PDX1
7beckwith-wiedemann syndrome30.1PLAGL1, ZFP57, ABCC8
8epilepsy syndrome30.1ABCC8, ZACN, KCNJ5, KCNJ11
9maturity-onset diabetes of the young30.1INS, HNF1B, PDX1, GCK, KCNJ11
10hyperinsulinism30.1KCNJ5, ABCC8, INS, IGF1, GCK, KCNJ11
11type 2 diabetes mellitus30.1KCNJ11, IGF1, INS, ABCC8, SLC2A2, PDX1
12transient neonatal diabetes mellitus10.6
13pancreatic beta cell agenesis with neonatal diabetes mellitus10.5
14diabetic ketoacidosis10.3
15type 1 diabetes mellitus10.3
16pneumonia10.3
17congenital hypothyroidism10.2
18hepatitis10.2
19abcc8-related transient neonatal diabetes mellitus 210.2
20abcc8-related permanent neonatal diabetes mellitus10.2
21gck-related permanent neonatal diabetes mellitus10.2
22kcnj11-related permanent neonatal diabetes mellitus10.2
23pdx1-related permanent neonatal diabetes mellitus10.2
24ins-related permanent neonatal diabetes mellitus10.2
25syndromic diarrhea10.1
26fanconi syndrome10.1
27intestinal atresia10.1
28exocrine pancreatic insufficiency10.1
29congenital diaphragmatic hernia10.1
30hepatitis a10.1
31congenital heart defect10.1
32diarrhea10.1
33glaucoma10.1
34hyperimmunoglobulin syndrome10.1
35organic acidemia10.1
36pervasive developmental disorder10.1
37thrombocytopenia10.1
38triple x syndrome10.1
39congenital hepatic fibrosis10.1
40diabetes mellitus, permanent neonatal, with cerebellar agenesis10.1
41diabetes mellitus, kcnj11-related transient neonatal10.1
42diabetes mellitus, neonatal, with congenital hypothyroidism10.1
43diabetes mellitus, insulin-dependent, neonatal10.1
44calciphylaxis10.0
45nondystrophic myotonia10.0
46morbid obesity10.0INS
47essential hypertension10.0INS
48acute myocardial infarction10.0KCNJ5
49donohue syndrome10.0INS
50turner syndrome10.0IGF1

Graphical network of the top 20 diseases related to Neonatal Diabetes Mellitus:



Diseases related to neonatal diabetes mellitus

Clinical Features for Neonatal Diabetes Mellitus

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Drugs & Therapeutics for Neonatal Diabetes Mellitus

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Neonatal Diabetes Mellitus

Drug clinical trials:

Search ClinicalTrials for Neonatal Diabetes Mellitus

Search NIH Clinical Center for Neonatal Diabetes Mellitus

Search CenterWatch for Neonatal Diabetes Mellitus

Genetic Tests for Neonatal Diabetes Mellitus

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22GTR
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Genetic tests related to Neonatal Diabetes Mellitus:

id Genetic test Affiliating Genes
1 Neonatal Diabetes Mellitus22

Anatomical Context for Neonatal Diabetes Mellitus

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32MalaCards
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MalaCards organs/tissues related to Neonatal Diabetes Mellitus:

32
Testes, Kidney, Pancreas, Brain, Heart

Animal Models for Neonatal Diabetes Mellitus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neonatal Diabetes Mellitus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.1HNF1B, PDX1, FOXP3, IGF1, INS, GCK
2MP:00030128.9KCNJ11, PDX1, FOXP3, INS, ABCC8, PLAGL1
3MP:00053708.7GCK, HNF1B, PDX1, FOXP3, INS, PTF1A
4MP:00053858.2KCNJ5, KCNJ11, FOXP3, IGF1, INS, PLAGL1
5MP:00053797.8TPO, KCNJ11, GCK, HNF1B, PDX1, FOXP3
6MP:00053787.8FOXP3, PDX1, HNF1B, GCK, KCNJ11, IGF1
7MP:00053767.6FOXP3, PDX1, HNF1B, GCK, KCNJ11, IGF1
8MP:00107687.6FOXP3, PDX1, HNF1B, GCK, KCNJ11, IGF1

Publications for Neonatal Diabetes Mellitus

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50PubMed
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Articles related to Neonatal Diabetes Mellitus:

(show top 50)    (show all 192)
idTitleAuthorsYear
1
Maternal and neonatal outcome of controlled gestational diabetes mellitus versus high risk group without gestational diabetes mellitus: a comparative study. (23348165)
2013
2
Permanent neonatal diabetes mellitus: prevalence and genetic diagnosis in the SEARCH for Diabetes in Youth Study. (23050777)
2013
3
Clinical presentation of 6q24 transient neonatal diabetes mellitus (6q24 TNDM) and genotype-phenotype correlation in an international cohort of patients. (23385738)
2013
4
Genetics of neonatal diabetes mellitus. (23456590)
2013
5
Age-adjusted glycated albumin: a more robust parameter to establish glycaemic control in neonatal diabetes mellitus. (24337793)
2013
6
Permanent neonatal diabetes mellitus caused by a novel mutation in the KCNJ11 gene. (24150202)
2013
7
Three cases of permanent neonatal diabetes mellitus: genotypes and management outcome. (22815030)
2012
8
Sulfonylurea-responsive neonatal diabetes mellitus diagnosed through molecular genetics in two children and in one adult after a long period of insulin treatment. (22978060)
2012
9
Clinical and molecular basis of transient neonatal diabetes mellitus in Brazilian children. (22749773)
2012
10
Recessive SLC19A2 mutations are a cause of neonatal diabetes mellitus in thiamine-responsive megaloblastic anaemia. (22369132)
2012
11
A new variant of a known mutation in two siblings with permanent neonatal diabetes mellitus. (21823539)
2011
12
Defects in beta cell CaA^+ signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitus. (21271337)
2011
13
Neonatal diabetes mellitus accompanied by diabetic ketoacidosis and mimicking neonatal sepsis: a case report. (21274328)
2010
14
Pancreatic hypoplasia presenting with neonatal diabetes mellitus in association with congenital heart defect and developmental delay. (20082465)
2010
15
Congenital hyperinsulinism and neonatal diabetes mellitus. (20878479)
2010
16
Transcribing neonatal diabetes mellitus. (20410520)
2010
17
Transient neonatal diabetes mellitus type 1. (20803656)
2010
18
The first case report of sulfonylurea use in a woman with permanent neonatal diabetes mellitus due to KCNJ11 mutation during a high-risk pregnancy. (20466780)
2010
19
An oral sulfonylurea in the treatment of transient neonatal diabetes mellitus. (19446154)
2009
20
A murine model of neonatal diabetes mellitus in Glis3-deficient mice. (19481545)
2009
21
Secondary consequences of beta cell inexcitability: identification and prevention in a murine model of K(ATP)-induced neonatal diabetes mellitus. (19187772)
2009
22
Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus. (18451997)
2008
23
Glibenclamide unresponsiveness in a Brazilian child with permanent neonatal diabetes mellitus and DEND syndrome due to a C166Y mutation in KCNJ11 (Kir6.2) gene. (19169493)
2008
24
Permanent neonatal diabetes mellitus caused by a novel homozygous (T168A) glucokinase (GCK) mutation: initial response to oral sulphonylurea therapy. (18571549)
2008
25
Microarray-based DNA methylation analysis of imprinted loci in a patient with transient neonatal diabetes mellitus. (19012334)
2008
26
Management of neonatal and infancy-onset diabetes mellitus. (17986830)
2007
27
Sulphonylurea treatment does not improve psychomotor development in children with KCNJ11 mutations causing permanent neonatal diabetes mellitus accompanied by developmental delay and epilepsy (DEND syndrome). (17888143)
2007
28
Epimutation of the TNDM locus and the Beckwith-Wiedemann syndrome centromeric locus in individuals with transient neonatal diabetes mellitus. (16402210)
2006
29
The genetic basis of neonatal diabetes mellitus. (17261973)
2006
30
From gene to disease; neonatal diabetes mellitus and the KCNJ11 gene]. (16375017)
2005
31
Neonatal diabetes mellitus: patient reports and review of current knowledge and clinical practice. (16459456)
2005
32
Pancreatic agenesis as cause for neonatal diabetes mellitus. (15770578)
2005
33
Unusual case of neonatal diabetes mellitus due to congenital pancreas agenesis. (16390394)
2005
34
Identification of a novel mutation in the GLUT2 gene in a patient with Fanconi-Bickel syndrome presenting with neonatal diabetes mellitus and galactosaemia. (12029458)
2002
35
X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. (11137992)
2001
36
Central precocious puberty in a girl with triple X syndrome and neonatal diabetes mellitus associated with paternal isodisomy of chromosome 6. (11515731)
2001
37
Neonatal diabetes mellitus. (10881652)
2000
38
An imprinted locus associated with transient neonatal diabetes mellitus. (10699182)
2000
39
Permanent neonatal diabetes mellitus: clinical presentation and epidemiology in Oman. (10212083)
1999
40
Significance of genetic testing for paternal uniparental disomy of chromosome 6 in neonatal diabetes mellitus. (9880447)
1999
41
Transient neonatal diabetes mellitus or an exaggerated steroid response? A case study. (9592462)
1998
42
Transient neonatal diabetes mellitus in a child with invdup(6)(q22q23) of paternal origin. (9450188)
1997
43
Paternal uniparental isodisomy of chromosome 6 in transient neonatal diabetes mellitus. (9296544)
1997
44
Transient neonatal diabetes mellitus with ketoacidosis and macroglossia. (17590652)
1995
45
Two interesting cases of transient neonatal diabetes mellitus. (8186824)
1994
46
Transient neonatal diabetes mellitus in a pair of twins. (2741692)
1989
47
Neonatal diabetes mellitus in first cousins. (3284688)
1988
48
Transient neonatal diabetes mellitus. Treatment with chlorpropamide. (760514)
1979
49
Neonatal diabetes mellitus. (4744225)
1973
50
NEONATAL DIABETES MELLITUS. (14198743)
1964

Genetic Variations for Neonatal Diabetes Mellitus

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Expression for genes affiliated with Neonatal Diabetes Mellitus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neonatal Diabetes Mellitus

Search GEO for disease gene expression data for Neonatal Diabetes Mellitus.

Pathways for genes affiliated with Neonatal Diabetes Mellitus

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Sources:
53Reactome, 49PharmGKB, 12EMD Millipore, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Neonatal Diabetes Mellitus

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Neonatal Diabetes Mellitus according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1cibenzoline4410.5ABCC8, KCNJ11
2minoxidil44 28 1112.5ABCC8, KCNJ5
3benzopyran4410.5ABCC8, KCNJ5
4dicyandiamide4410.5ABCC8, KCNJ5
5meglitinide4410.4INS, ABCC8
6chromium picolinate4410.4INS, GCK
7mitiglinide44 1111.4INS, ABCC8
8alloxan4410.4SLC2A2, GCK
9nicorandil44 2811.4KCNJ5, KCNJ11, ABCC8
10mgadp4410.4KCNJ5, KCNJ11, ABCC8
11pinacidil4410.4ABCC8, KCNJ5
12cromakalim44 2811.3KCNJ5, KCNJ11, ABCC8
13gliclazide44 49 1112.3KCNJ11, ABCC8, INS
14glipizide44 1111.3INS, KCNJ5, ABCC8
15levosimendan44 1111.3KCNJ11, KCNJ5
16i-app4410.3GCK, PDX1, INS
17Glyburide1110.3ABCC8, KCNJ11, KCNJ5
18nateglinide44 49 1112.3INS, KCNJ5, ABCC8
19mecasermin44 1111.3INS, IGF1
20proglucagon4410.3SLC2A2, PDX1, GCK
213-o-methylglucose4410.2GCK, SLC2A2
22repaglinide44 49 1112.2INS, ABCC8, KCNJ5, KCNJ11
23glimepiride44 49 1112.2KCNJ5, INS, KCNJ11, ABCC8
24glibenclamide44 28 49 5913.2ABCC8, INS, KCNJ5, KCNJ11
25aicar44 11 2412.1IGF1, GCK, INS
26preproinsulin4410.1INS, PDX1, GCK, SLC2A2
27incretin4410.1INS, PDX1, GCK, SLC2A2
28chlorpropamide44 1111.1ABCC8, INS
29nicotinamide44 1111.1INS, PDX1, HNF1B
30tertiapin-q5910.1KCNJ11, KCNJ5
31oxandrolone44 1111.1INS, IGF1
32streptozotocin4410.1PDX1, INS, SLC2A2, GCK
332-deoxyglucose44 1111.0SLC2A2, INS, GCK, IGF1
34diazoxide44 59 28 1113.0ABCC8, KCNJ5, KCNJ11, GCK, INS
35tolbutamide44 49 28 1113.0ABCC8, KCNJ5, INS, GCK, KCNJ11
36octreotide44 59 28 1113.0INS, PLAGL1, IGF1
37metformin44 49 1111.9KCNJ11, GCK, INS, ABCC8, IGF1
38uric acid44 2410.7HNF1B, INS, TPO
39glycogen44 2410.6ONECUT1, SLC2A2, ABCC8, INS, GCK
40sulfonylurea449.6GCK, KCNJ11, KCNJ5, SLC2A2, ABCC8, INS
41katp449.6INS, SLC2A2, ABCC8, PDX1, GCK, KCNJ11
42testosterone44 59 11 2412.6INS, ABCC8, PLAGL1, KCNJ5, IGF1, TPO
43cholesterol44 28 11 2412.5INS, IGF1, HNF1B, TPO, GCK, ABCC8
44potassium44 11 2411.5TPO, ZACN, GCK, KCNJ11, KCNJ5, SLC2A2
45c-peptide449.5TPO, SLC2A2, INS, IGF1, PDX1, GCK
46glutamate449.5TPO, ABCC8, KCNJ5, KCNJ11, INS, GCK
47oligonucleotide449.3KRBOX4, GCK, PDX1, TPO, SLC2A2, HNF1B
48arginine449.2INS, IGF1, ABCC8, KCNJ11, SLC2A2, TPO
49atp44 2810.0GCK, SLC2A2, ABCC8, KCNJ5, KCNJ11, TPO
50glucose448.4SLC2A2, ABCC8, INS, IGF1, PDX1, HNF1B

GO Terms for genes affiliated with Neonatal Diabetes Mellitus

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16Gene Ontology
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Cellular components related to Neonatal Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated potassium channel complexGO:0080769.9ABCC8, KCNJ11, KCNJ5

Biological processes related to Neonatal Diabetes Mellitus according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1detection of glucoseGO:05159410.2PDX1, GCK
2positive regulation of glycolysisGO:04582110.1GCK, IGF1, INS
3positive regulation of glycogen biosynthetic processGO:04572510.1INS, IGF1, GCK
4exocrine pancreas developmentGO:03101710.0PTF1A, IGF1, PDX1
5negative regulation of gluconeogenesisGO:04572110.0GCK, INS
6hindbrain developmentGO:03090210.0PTF1A, HNF1B
7energy reserve metabolic processGO:0061129.9KCNJ11, INS, ABCC8, SLC2A2
8glucose transportGO:0157589.9SLC2A2, INS, GCK
9regulation of insulin secretionGO:0507969.8KCNJ11, GCK, INS, ABCC8, SLC2A2
10glucose metabolic processGO:0060069.7KCNJ11, PDX1, INS, ONECUT1
11glucose homeostasisGO:0425939.6INS, PDX1, GCK
12endocrine pancreas developmentGO:0310189.1ONECUT1, PTF1A, SLC2A2, INS, PDX1, HNF1B
13positive regulation of transcription from RNA polymerase II promoterGO:0459449.0HNF1B, PDX1, FOXP3, IGF1, PLAGL1, ONECUT1

Molecular functions related to Neonatal Diabetes Mellitus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:00515910.0INS, IGF1

Products for genes affiliated with Neonatal Diabetes Mellitus

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  • Antibodies
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Sources for Neonatal Diabetes Mellitus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet