MCID: NNT033
MIFTS: 33

Neonatal Hypoxic and Ischemic Brain Injury

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards integrated aliases for Neonatal Hypoxic and Ischemic Brain Injury:

Name: Neonatal Hypoxic and Ischemic Brain Injury 55
Hypoxic-Ischemic Encephalopathy 55 69
Perinatal Asphyxia 55 69
Perinatal Hypoxia 55 69
Hypoxic and Ischemic Brain Injury in the Newborn 55
Encephalopathies Hypoxic-Ischemic 51
Hie 55

Characteristics:

Orphanet epidemiological data:

55
neonatal hypoxic and ischemic brain injury
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Infancy,Neonatal;

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Orphanet 55 ORPHA137577
UMLS via Orphanet 70 C0752304
ICD10 via Orphanet 33 P11.1

Summaries for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards based summary : Neonatal Hypoxic and Ischemic Brain Injury, also known as hypoxic-ischemic encephalopathy, is related to lennox-gastaut syndrome and cerebral palsy, spastic quadriplegic, 1. An important gene associated with Neonatal Hypoxic and Ischemic Brain Injury is ENO2 (Enolase 2), and among its related pathways/superpathways are Neuroscience and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Dopamine and Levodopa have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotypes are behavior/neurological and cellular

Related Diseases for Neonatal Hypoxic and Ischemic Brain Injury

Diseases related to Neonatal Hypoxic and Ischemic Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 lennox-gastaut syndrome 11.2
2 cerebral palsy, spastic quadriplegic, 1 11.1
3 asphyxia neonatorum 11.1
4 hypoxia 10.3
5 finger agnosia 10.3 ENO2 MBP
6 juvenile pilocytic astrocytoma 10.2 ENO2 MBP
7 optic nerve glioma 10.2 ENO2 MBP
8 secondary progressive multiple sclerosis 10.2 ENO2 MBP
9 intraocular retinoblastoma 10.2 ENO2 PVALB
10 cardiac arrest 10.1 CKB ENO2
11 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.1 MBP TH
12 rhabdomyosarcoma 2 10.1 ENO2 TH
13 multiple system atrophy 1 10.0 MBP TH
14 nodular ganglioneuroblastoma 10.0 BDNF ENO2
15 hyperphenylalaninemia 10.0 MBP TH
16 neuronitis 10.0
17 oligodendroglioma 10.0 ENO2 MBP
18 supranuclear palsy, progressive, 1 9.9 PVALB TH
19 encephalopathy 9.9
20 childhood disintegrative disease 9.9 BDNF MBP
21 synucleinopathy 9.9 PVALB TH
22 meningoencephalitis 9.9 BDNF MBP
23 sturge-weber syndrome 9.8
24 cerebral palsy 9.8
25 ischemia 9.8
26 relapsing-remitting multiple sclerosis 9.8 BDNF MBP
27 tendinosis 9.8 BDNF TH
28 neuronal ceroid-lipofuscinoses 9.8 MBP PVALB SLC1A3
29 early-onset schizophrenia 9.8 BDNF TH
30 toxic encephalopathy 9.7 BDNF TH
31 central hypoventilation syndrome, congenital 9.7 BDNF TH
32 traumatic brain injury 9.7 BDNF ENO2 MBP
33 brain injury 9.7 BDNF ENO2 MBP
34 disease of mental health 9.7 BDNF PVALB
35 west syndrome 9.7 PVALB TH
36 gilles de la tourette syndrome 9.6 BDNF SLC1A3
37 status epilepticus 9.6 BDNF ENO2 PVALB
38 peripheral nervous system neoplasm 9.5 BDNF ENO2 TH
39 autonomic nervous system neoplasm 9.5 BDNF ENO2 TH
40 temporal lobe epilepsy 9.5 BDNF PVALB SLC1A3
41 nervous system disease 9.5 BDNF MBP TH
42 central nervous system disease 9.5 BDNF MBP TH
43 attention deficit-hyperactivity disorder 9.4 BDNF SLC1A3 TH
44 neuroblastoma 9.4 BDNF ENO2 TH
45 parkinson disease, late-onset 9.4 BDNF PVALB TH
46 bipolar disorder 9.3 BDNF PVALB TH
47 autism 9.3 BDNF MBP TH
48 mood disorder 9.3 BDNF TH
49 amyotrophic lateral sclerosis 1 9.0 BDNF PVALB SLC1A3 TH
50 schizophrenia 8.7 BDNF MBP PVALB SLC1A3 TH

Graphical network of the top 20 diseases related to Neonatal Hypoxic and Ischemic Brain Injury:



Diseases related to Neonatal Hypoxic and Ischemic Brain Injury

Symptoms & Phenotypes for Neonatal Hypoxic and Ischemic Brain Injury

MGI Mouse Phenotypes related to Neonatal Hypoxic and Ischemic Brain Injury:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 BDNF CKB ENO2 MBP PVALB SLC1A3
2 cellular MP:0005384 9.63 BDNF ENO2 MBP PVALB SLC1A3 TH
3 nervous system MP:0003631 9.5 ENO2 MBP PVALB SLC1A3 TH BDNF
4 no phenotypic analysis MP:0003012 8.92 BDNF PVALB SLC1A3 TH

Drugs & Therapeutics for Neonatal Hypoxic and Ischemic Brain Injury

Drugs for Neonatal Hypoxic and Ischemic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 136)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
2
Levodopa Approved Phase 4 59-92-7 6047
3
Tranexamic Acid Approved Phase 4 1197-18-8 5526
4
Vitamin C Approved, Nutraceutical Phase 4,Not Applicable 50-81-7 54670067 5785
5 Tocopherol Approved, Investigational, Nutraceutical Phase 4
6
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
7 Neurotransmitter Agents Phase 4,Phase 1,Phase 2,Early Phase 1,Not Applicable
8 Dihydroxyphenylalanine Phase 4
9 Dopamine Agents Phase 4,Phase 2
10 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
11 Protective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Autonomic Agents Phase 4,Phase 1,Phase 2,Not Applicable
13 Carbidopa, levodopa drug combination Phase 4
14 Micronutrients Phase 4,Not Applicable
15 Tocopherols Phase 4
16 Tocotrienols Phase 4
17 Trace Elements Phase 4,Not Applicable
18 Vitamins Phase 4,Phase 1,Phase 2,Not Applicable
19 Antioxidants Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
20 Coagulants Phase 4
21 Hemostatics Phase 4
22 Antifibrinolytic Agents Phase 4
23 Tocotrienol Investigational, Nutraceutical Phase 4 6829-55-6
24
Benzocaine Approved, Investigational Phase 3,Not Applicable 1994-09-7, 94-09-7 2337
25
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
26
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
27
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 657311 5754
28 Racepinephrine Approved Phase 2, Phase 3 329-65-7
29
Mannitol Approved, Investigational Phase 3 69-65-8 6251 453
30
Allopurinol Approved Phase 3 315-30-0 2094
31 tannic acid Approved, Nutraceutical Phase 3,Not Applicable
32
Choline Approved, Nutraceutical Phase 3 62-49-7 305
33
Butyric Acid Experimental, Investigational Phase 2, Phase 3 107-92-6 264
34 Analgesics Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
35 calcium channel blockers Phase 3
36 Central Nervous System Depressants Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable
37 Tocolytic Agents Phase 3
38 Hematinics Phase 3,Phase 1,Phase 2
39 Anesthetics Phase 3,Phase 1,Phase 2,Not Applicable
40 Anti-Arrhythmia Agents Phase 3
41 Epoetin alfa Phase 3,Phase 1,Phase 2 113427-24-0
42 Anticonvulsants Phase 3,Phase 2,Phase 1,Not Applicable
43 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
44 Calcium, Dietary Phase 3
45 diuretics Phase 3,Phase 1,Phase 2
46 Natriuretic Agents Phase 3,Phase 1,Phase 2
47 Neuroprotective Agents Phase 3,Phase 2,Phase 1
48 Nootropic Agents Phase 3,Phase 2,Not Applicable
49 Anti-Inflammatory Agents Phase 2, Phase 3,Not Applicable
50 Antirheumatic Agents Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 109)

# Name Status NCT ID Phase Drugs
1 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
2 Single High Dose Vitamin C, E in Severe Birth Asphyxia Completed NCT01743742 Phase 4 Vitamin E, Vitamin C
3 Prevention of Postpartum Hemorrhage With TXA Not yet recruiting NCT03326596 Phase 4 Tranexamic Acid 1000 mg/10ml normal saline infusion
4 Efficacy of Erythropoietin to Improve Survival and Neurological Outcome in Hypoxic Ischemic Encephalopathy Unknown status NCT01732146 Phase 3 erythropoietin Beta;Placebo
5 Efficacy Study of Hypothermia Plus Magnesium Sulphate(MgSO4) in the Management of Term and Near Term Babies With Hypoxic Ischemic Encephalopathy Unknown status NCT01646619 Phase 3 Magnesium Sulphate;Placebo
6 Supreme-LMA for Neonatal Resuscitation: a Prospective, Randomized Single-center Study Unknown status NCT01963936 Phase 3
7 Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy Completed NCT00890409 Phase 3
8 Late Hypothermia for Hypoxic-Ischemic Encephalopathy Completed NCT00614744 Phase 2, Phase 3
9 Whole-Body Cooling for Birth Asphyxia in Term Infants Completed NCT00005772 Phase 3
10 Neonatal Resuscitation in Zambia Completed NCT00097097 Phase 3
11 High Dose of Erythropoietin Analogue After Cardiac Arrest Completed NCT00999583 Phase 3 EPOETINE ALPHA
12 Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial Completed NCT00880087 Phase 3
13 PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns Recruiting NCT03079167 Phase 3 Epoetin Alfa;Normal saline
14 Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy Recruiting NCT03181646 Phase 3 citicoline
15 Preemie Hypothermia for Neonatal Encephalopathy Recruiting NCT01793129 Phase 2, Phase 3
16 Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns Recruiting NCT02700828 Phase 2, Phase 3 Hydrocortisone;Placebo
17 High-dose Erythropoietin for Asphyxia and Encephalopathy Recruiting NCT02811263 Phase 3 Normal saline placebo;Erythropoietin
18 Erythropoietin in Management of Neonatal Hypoxic Ischemic Encephalopathy Not yet recruiting NCT03163589 Phase 3 Erythropoietin;normal saline
19 Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome Not yet recruiting NCT03162653 Phase 3 Allopurinol;Mannitol
20 Optimizing (Longer, Deeper) Cooling for Neonatal Hypoxic-Ischemic Encephalopathy(HIE) Terminated NCT01192776 Phase 3
21 Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth Unknown status NCT01545271 Phase 1, Phase 2 xenon gas
22 Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) Unknown status NCT01913340 Phase 1, Phase 2 Erythropoietin;Normal saline
23 Whole Body Cooling Using Phase Changing Material Unknown status NCT01138176 Phase 1, Phase 2
24 Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia Completed NCT01241019 Phase 2 Topiramate in newborns with hypoxic ischemic encephalopathy treated with therapeutic hypothermia
25 Study of Cerebrolysin for Treatment of Infants With History of Neonatal Hypoxic Ischemic Encephalopathy Completed NCT01059461 Phase 2 Cerebrolysin®
26 Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy Completed NCT01765218 Phase 1, Phase 2 Topiramate;Placebo
27 Systemic Hypothermia Improves Outcome of Hypoxic-Ischemic Encephalopathy Completed NCT00817401 Phase 1, Phase 2
28 Moderate Hypothermia in Neonatal Hypoxic Ischemic Encephalopathy Completed NCT02826941 Phase 2
29 Erythropoietin in Infants With Hypoxic Ischemic Encephalopathy (HIE) Completed NCT00945789 Phase 1, Phase 2 Human recombinant erythropoietin
30 Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia Completed NCT01862250 Phase 1, Phase 2 Clonidine (Duraclon®)
31 Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy Completed NCT00808704 Phase 1, Phase 2 recombinant human erythropoietin
32 Darbe Administration in Newborns Undergoing Cooling for Encephalopathy Completed NCT01471015 Phase 1, Phase 2 Darbepoetin alfa;Darbepoetin alfa;Placebo
33 Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia Completed NCT00934700 Phase 1, Phase 2
34 NEMO1:NEonatal Seizure Using Medication Off-patent Completed NCT01434225 Phase 1, Phase 2 Bumetanide
35 A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy Recruiting NCT02612155 Phase 2
36 Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth Recruiting NCT02071394 Phase 2 Xenon gas
37 Levetiracetam Treatment of Neonatal Seizures: Safety and Efficacy Phase II Study Recruiting NCT02229123 Phase 2 Intravenous Levetiracetam
38 Neuroprotective Effect of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonatal Encephalopathy Recruiting NCT02551003 Phase 1, Phase 2 Autologous cord blood
39 Mild Encephalopathy in the Newborn Treated With Darbepoetin Recruiting NCT03071861 Phase 2 Darbepoetin Alfa;Normal Saline
40 TIBOHCA: Safety, Tolerability and Pharmacokinetics of 2-Iminobiotin (2-IB) After OHCA Recruiting NCT02836340 Phase 1, Phase 2 2-Iminobiotin
41 Effect of Methylphenidate on Ecologic Function in Paediatric Acquired Brain Injury Population Recruiting NCT02227056 Phase 2 Methylphenidate
42 Autologous Cord Blood and Human Placental Derived Stem Cells in Neonates With Severe Hypoxic-Ischemic Encephalopathy Not yet recruiting NCT02434965 Phase 2 HPDSC;Cord blood
43 Neonatal Hypoxic Ischemic Encephalopathy : Safety and Feasibility Study of a Curative Treatment With Autologous Cord Blood Stem Cells Not yet recruiting NCT02881970 Phase 1, Phase 2 autologous cord blood stem cell
44 Umbilical Cord Derived Mesenchymal Stem Cells Therapy in Hypoxic Ischemic Encephalopathy Unknown status NCT01962233 Phase 1
45 Autologous Cord Blood Cell Therapy for Neonatal Encephalopathy Unknown status NCT02256618 Phase 1
46 Cord Blood for Neonatal Hypoxic-ischemic Encephalopathy Completed NCT00593242 Phase 1
47 Pilot Study of Head Cooling in Preterm Infants With Hypoxic Ischemic Encephalopathy Completed NCT00620711 Phase 1
48 Autologous Cord Blood Cells for Brain Injury in Term Newborns Completed NCT01649648 Phase 1
49 Neonatal Erythropoietin in Asphyxiated Term Newborns Completed NCT00719407 Phase 1 erythropoietin
50 Hypoxic-Ischemic Encephalopathy Therapy Optimization in Neonates for Better Neuroprotection With Inhalative CO2 Recruiting NCT02700854 Phase 1

Search NIH Clinical Center for Neonatal Hypoxic and Ischemic Brain Injury

Genetic Tests for Neonatal Hypoxic and Ischemic Brain Injury

Anatomical Context for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards organs/tissues related to Neonatal Hypoxic and Ischemic Brain Injury:

38
Brain

Publications for Neonatal Hypoxic and Ischemic Brain Injury

Articles related to Neonatal Hypoxic and Ischemic Brain Injury:

(show top 50) (show all 64)
# Title Authors Year
1
Antepartum risk factors for moderate to severe neonatal hypoxic ischemic encephalopathy: a Swedish national cohort study. ( 29450878 )
2018
2
Hypoxic-Ischemic Encephalopathy and Other Neonatal Encephalopathies. ( 29432237 )
2018
3
Benefits of starting hypothermia treatment within 6A h vs. 6-12A h in newborns with moderate neonatal hypoxic-ischemic encephalopathy. ( 29433475 )
2018
4
The Applicability of Amide Proton Transfer Imaging in the Nervous System: Focus on Hypoxic-Ischemic Encephalopathy in the Neonate. ( 28942555 )
2017
5
The Neuroprotective Strategic Analysis for Patients with Acute Myocardial Infarction Combined with Hypoxic Ischemic Encephalopathy in ICU. ( 28065791 )
2017
6
Delayed Transient Cortical Blindness from Hypoxic Ischemic Encephalopathy. ( 28390792 )
2017
7
Feasibility and Safety of Controlled Active Hypothermia Treatment During Transport in Neonates With Hypoxic-Ischemic Encephalopathy. ( 28938291 )
2017
8
Perinatal inflammation/infection and its association with correction of metabolic acidosis in hypoxic-ischemic encephalopathy. ( 26796123 )
2016
9
Hypoxic-Ischemic Encephalopathy and Serum Magnesium Monitoring and Maintenance. ( 27194611 )
2016
10
Therapeutic hypothermia for infants with hypoxic ischemic encephalopathy: A five years' single center experience in Kuwait. ( 27197929 )
2016
11
Sex-dependent mitochondrial respiratory impairment and oxidative stress in a rat model of neonatal hypoxic-ischemic encephalopathy. ( 27197831 )
2016
12
The association between pro- and anti-inflammatory cytokine polymorphisms and periventricular leukomalacia in newborns with hypoxic-ischemic encephalopathy. ( 27217792 )
2016
13
Comparison of Passive and Servo-Controlled Active Cooling for Infants with Hypoxic-Ischemic Encephalopathy during Neonatal Transfers. ( 27182995 )
2016
14
Umbilical cord blood concentrations of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) and glial fibrillary acidic protein (GFAP) in neonates developing hypoxic-ischemic encephalopathy. ( 26135781 )
2016
15
The therapeutic effect of CD133(+) cells derived from human umbilical cord blood on neonatal mouse hypoxic-ischemic encephalopathy model. ( 27287679 )
2016
16
Are neonatal stroke and hypoxic-ischemic encephalopathy related? ( 27234275 )
2016
17
Early EEG Grade and Outcome at 5 Years After Mild Neonatal Hypoxic Ischemic Encephalopathy. ( 27650049 )
2016
18
Erythropoietin improves hypoxic-ischemic encephalopathy in Neonatal Rats after Short-term Anoxia by Enhancing Angiogenesis. ( 27659964 )
2016
19
The Association between NOS3 Gene Polymorphisms and Hypoxic-Ischemic Encephalopathy Susceptibility and Symptoms in Chinese Han Population. ( 28070505 )
2016
20
Implementation of a Neurocritical Care Program: Improved Seizure Detection and Decreased Antiseizure Medication at Discharge in Neonates With Hypoxic-Ischemic Encephalopathy. ( 27647155 )
2016
21
The temporal characteristics of seizures in neonatal hypoxic ischemic encephalopathy treated with hypothermia. ( 26571073 )
2015
22
Serum levels of S-100I^ correlate with the clinical status and severity of hypoxic-ischemic encephalopathy in neonates. ( 26600537 )
2015
23
Impact of Thrombophilia on the Risk of Hypoxic-Ischemic Encephalopathy in Term Neonates. ( 26400660 )
2015
24
NF-I_B Signaling is Involved in the Effects of Intranasally Engrafted Human Neural Stem Cells on Neurofunctional Improvements in Neonatal Rat Hypoxic-Ischemic Encephalopathy. ( 26255634 )
2015
25
ER stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy. ( 26261584 )
2015
26
Dietary Interventions Designed to Protect the Perinatal Brain from Hypoxic-Ischemic Encephalopathy - Creatine Prophylaxis and The Need for Multi-Organ Protection. ( 26576837 )
2015
27
Downregulation of Umbilical Cord Blood Levels of miR-374a in Neonatal Hypoxic Ischemic Encephalopathy. ( 26001314 )
2015
28
Hypoxic ischemic encephalopathy in a case of intranuclear rod myopathy without any prenatal sentinel event. ( 24787270 )
2014
29
Apolipoprotein E genotype and outcome in infants with hypoxic-ischemic encephalopathy. ( 24322171 )
2014
30
Association of NOS3 gene variants and clinical contributors of hypoxic-ischemic encephalopathy. ( 25140814 )
2014
31
Epilepsy and West syndrome in neonates with hypoxic-ischemic encephalopathy. ( 24274080 )
2013
32
Successful Hypothermia Treatment of Hypoxic-Ischemic Encephalopathy in a Neonate with Epidermolysis Bullosa. ( 23934101 )
2013
33
Serum biomarkers of MRI brain injury in neonatal hypoxic ischemic encephalopathy treated with whole-body hypothermia: a pilot study. ( 23392373 )
2013
34
Hypoxic-ischemic encephalopathy following vaso-occlusive crisis in hemoglobin SC disease. ( 29443262 )
2012
35
Congenital diaphragmatic hernia repair during whole body hypothermia for neonatal hypoxic ischemic encephalopathy. ( 23190939 )
2012
36
Association of NOS3 tag polymorphisms with hypoxic-ischemic encephalopathy. ( 21674837 )
2011
37
Cortical blindness and paraplegia following hypoxic ischemic encephalopathy as a complication of common krait bite. ( 21876601 )
2011
38
Activin A in asphyxiated full-term newborns with hypoxic ischemic encephalopathy. ( 20036850 )
2010
39
Status epilepticus and capillary leak syndrome in a neonate related to perinatal hypoxic-ischemic encephalopathy. ( 20140779 )
2010
40
Prolonged EEG depression in term and near-term infants with hypoxic ischemic encephalopathy and later development of West syndrome. ( 20887363 )
2010
41
Urinary S100A1B and S100BB to predict hypoxic ischemic encephalopathy at term. ( 19482672 )
2009
42
Hypoxic/ischemic encephalopathy associated with placental insufficiency in a cloned foal. ( 19112119 )
2009
43
[Changes of electroencephalographic background patterns and serum neuron specific enolase levels in neonates with hypoxic-ischemic encephalopathy]. ( 19292949 )
2009
44
Expression of T subsets and mIL-2R in peripheral blood of newborns with hypoxic ischemic encephalopathy. ( 18661772 )
2008
45
Neurokinin A level in hypoxic-ischemic encephalopathy. ( 18353057 )
2008
46
[Efficacy of hyperbaric oxygen therapy under different pressures on neonatal hypoxic-ischemic encephalopathy]. ( 18433528 )
2008
47
Intrapartum electronic fetal heart rate monitoring and the identification of metabolic acidosis and hypoxic-ischemic encephalopathy. ( 17826429 )
2007
48
The dynamic changes of plasma neuropeptide y and neurotensin and their role in regulating cerebral hemodynamics in neonatal hypoxic-ischemic encephalopathy. ( 17616921 )
2007
49
A decoy oligonucleotide inhibiting nuclear factor-kappaB binding to the IgGkappaB consensus site reduces cerebral injury and apoptosis in neonatal hypoxic-ischemic encephalopathy. ( 17348043 )
2007
50
Brief update on animal models of hypoxic-ischemic encephalopathy and neonatal stroke. ( 16391429 )
2006

Variations for Neonatal Hypoxic and Ischemic Brain Injury

Expression for Neonatal Hypoxic and Ischemic Brain Injury

Search GEO for disease gene expression data for Neonatal Hypoxic and Ischemic Brain Injury.

Pathways for Neonatal Hypoxic and Ischemic Brain Injury

Pathways related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 ENO2 MBP SLC1A3 TH
2 11.54 BDNF SLC1A3 TH
3 11.05 BDNF MBP
4 10.7 BDNF SLC1A3 TH

GO Terms for Neonatal Hypoxic and Ischemic Brain Injury

Cellular components related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 terminal bouton GO:0043195 9.26 PVALB TH
2 cell periphery GO:0071944 9.16 MBP SLC1A3
3 myelin sheath GO:0043209 9.13 CKB ENO2 MBP
4 neuronal cell body GO:0043025 9.1 CKB ENO2 MBP PVALB SLC1A3 TH

Biological processes related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 substantia nigra development GO:0021762 9.16 CKB MBP
2 response to light stimulus GO:0009416 8.96 SLC1A3 TH
3 sensory perception of sound GO:0007605 8.8 MBP SLC1A3 TH

Molecular functions related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 amino acid binding GO:0016597 8.62 SLC1A3 TH

Sources for Neonatal Hypoxic and Ischemic Brain Injury

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