HIE
MCID: NNT033
MIFTS: 25

Neonatal Hypoxic and Ischemic Brain Injury (HIE) malady

Neuronal diseases category

Summaries for Neonatal Hypoxic and Ischemic Brain Injury

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Neonatal Hypoxic and Ischemic Brain Injury, also known as hypoxic-ischemic encephalopathy, is related to cerebritis and west syndrome. An important gene associated with Neonatal Hypoxic and Ischemic Brain Injury is EPO (erythropoietin), and among its related pathways are HIF-1 signaling pathway and HIF-1-alpha transcription factor network. The compounds pimonidazole and cocl2 have been mentioned in the context of this disorder. Affiliated tissues include brain.

Aliases & Classifications for Neonatal Hypoxic and Ischemic Brain Injury

About this section
Sources:
48Orphanet, 60UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
hypoxic-ischemic encephalopathy:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

neonatal hypoxic and ischemic brain injury 48
hypoxic-ischemic encephalopathy 48 60
perinatal asphyxia 48 60
perinatal hypoxia 48 60
hypoxic and ischemic brain injury in the newborn 48
hie 48


Related Diseases for Neonatal Hypoxic and Ischemic Brain Injury

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Neonatal Hypoxic and Ischemic Brain Injury:



Diseases related to neonatal hypoxic and ischemic brain injury

Clinical Features for Neonatal Hypoxic and Ischemic Brain Injury

About this section

Drugs & Therapeutics for Neonatal Hypoxic and Ischemic Brain Injury

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Neonatal Hypoxic and Ischemic Brain Injury

Drug clinical trials:

Search ClinicalTrials for Neonatal Hypoxic and Ischemic Brain Injury

Search NIH Clinical Center for Neonatal Hypoxic and Ischemic Brain Injury

Search CenterWatch for Neonatal Hypoxic and Ischemic Brain Injury

Genetic Tests for Neonatal Hypoxic and Ischemic Brain Injury

About this section

Anatomical Context for Neonatal Hypoxic and Ischemic Brain Injury

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Neonatal Hypoxic and Ischemic Brain Injury:

32
Brain

Animal Models for Neonatal Hypoxic and Ischemic Brain Injury or affiliated genes

About this section

Publications for Neonatal Hypoxic and Ischemic Brain Injury

About this section

Genetic Variations for Neonatal Hypoxic and Ischemic Brain Injury

About this section

Expression for genes affiliated with Neonatal Hypoxic and Ischemic Brain Injury

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Neonatal Hypoxic and Ischemic Brain Injury

Search GEO for disease gene expression data for Neonatal Hypoxic and Ischemic Brain Injury.

Pathways for genes affiliated with Neonatal Hypoxic and Ischemic Brain Injury

About this section
Sources:
29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 53Reactome
See all sources

Compounds for genes affiliated with Neonatal Hypoxic and Ischemic Brain Injury

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
See all sources

Compounds related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1pimonidazole449.3EPO, HIF1A
2cocl2449.3EPO, HIF1A
3cobalt chloride449.3EPO, HIF1A
4fumarate44 1110.3HIF1A, EPO
5deferoxamine44 1110.3EPO, HIF1A
6cobalt44 2410.3EPO, HIF1A
7topotecan44 1110.2EPO, HIF1A
8doxycycline44 1110.2HIF1A, EPO
9celecoxib44 59 28 49 11 2414.2EPO, HIF1A
10carboplatin44 49 1111.1EPO, HIF1A
11mitomycin c449.1EPO, HIF1A
12methotrexate44 49 1111.0HIF1A, EPO
13rapamycin449.0EPO, HIF1A
14ascorbic acid44 249.9EPO, HIF1A
15butyrate448.7EPO, HIF1A

GO Terms for genes affiliated with Neonatal Hypoxic and Ischemic Brain Injury

About this section
Sources:
16Gene Ontology
See all sources

Biological processes related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to hypoxiaGO:0714569.0EPO, HIF1A
2hemoglobin biosynthetic processGO:0425418.9EPO, HIF1A
3regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614188.7EPO, HIF1A

Products for genes affiliated with Neonatal Hypoxic and Ischemic Brain Injury

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neonatal Hypoxic and Ischemic Brain Injury

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet