HIE
MCID: NNT033
MIFTS: 30

Neonatal Hypoxic and Ischemic Brain Injury (HIE) malady

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Neonatal Hypoxic and Ischemic Brain Injury

Aliases & Descriptions for Neonatal Hypoxic and Ischemic Brain Injury:

Name: Neonatal Hypoxic and Ischemic Brain Injury 56
Hypoxic-Ischemic Encephalopathy 56 69
Perinatal Asphyxia 56 69
Perinatal Hypoxia 56 69
Hypoxic and Ischemic Brain Injury in the Newborn 56
Encephalopathies Hypoxic-Ischemic 52
Hie 56

Characteristics:

Orphanet epidemiological data:

56
neonatal hypoxic and ischemic brain injury
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Infancy,Neonatal;

Classifications:



External Ids:

Orphanet 56 ORPHA137577
ICD10 via Orphanet 34 P11.1

Summaries for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards based summary : Neonatal Hypoxic and Ischemic Brain Injury, also known as hypoxic-ischemic encephalopathy, is related to lennox-gastaut syndrome and cerebral palsy, spastic quadriplegic, 1. An important gene associated with Neonatal Hypoxic and Ischemic Brain Injury is ENO2 (Enolase 2), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Neuroscience. The drugs Magnesium Sulfate and Vitamin C have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotypes are behavior/neurological and cellular

Related Diseases for Neonatal Hypoxic and Ischemic Brain Injury

Diseases related to Neonatal Hypoxic and Ischemic Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
id Related Disease Score Top Affiliating Genes
1 lennox-gastaut syndrome 11.2
2 cerebral palsy, spastic quadriplegic, 1 11.0
3 hypoxia 10.2
4 mirror agnosia 10.2 ENO2 MBP
5 postauricular lymphadenitis 10.2 ENO2 MBP
6 central nervous system hemangioma 10.1 ENO2 MBP
7 flat ductal epithelial atypia 10.1 ENO2 MBP
8 multiple chemical sensitivity 10.1 ENO2 PVALB
9 rhabdomyosarcoma 2, alveolar 10.1 ENO2 TH
10 peyronie's disease 10.0 MBP SLC1A3
11 pseudo-gaucher disease 10.0 MBP TH
12 urinary tract obstruction 10.0 BDNF ENO2
13 mastoiditis 10.0 CKB ENO2
14 prion disease with protracted course 10.0 ENO2 PVALB
15 active cochlear meniere's disease 10.0 BDNF MBP
16 autism 19 10.0 MBP TH
17 urea cycle disorder 10.0 BDNF MBP
18 kashin-beck disease 9.9 BDNF TH
19 cytomegalic congenital adrenal hypoplasia 9.9 BDNF TH
20 neonatal jaundice 9.9 BDNF MBP
21 neuronitis 9.9
22 chronic infections, due to mbl deficiency 9.9 BDNF TH
23 breast reconstruction 9.9 BDNF ENO2 MBP
24 ovarian mucinous adenocarcinoma 9.9 BDNF TH
25 encephalopathy 9.9
26 idiopathic generalized epilepsy 9.8 BDNF ENO2 PVALB
27 postmenopausal atrophic vaginitis 9.8 BDNF ENO2 TH
28 cystadenoma 9.8 BDNF ENO2 TH
29 gallbladder adenoma 9.8 PVALB TH
30 thalassemia 9.8 BDNF PVALB SLC1A3
31 substance-induced psychosis 9.8 BDNF MBP TH
32 epithelioid type angiomyolipoma 9.8 BDNF MBP TH
33 endotheliitis 9.7
34 cerebral palsy 9.7
35 dyskinetic cerebral palsy 9.7
36 chorioamnionitis 9.7
37 hemolytic-uremic syndrome 9.7
38 kernicterus 9.7
39 ischemia 9.7
40 cerebritis 9.7
41 weber syndrome 9.7
42 neuroblastoma 9.7 BDNF ENO2 TH
43 long qt syndrome 5 9.5 BDNF PVALB SLC1A3 TH
44 schizophrenia 9.4 BDNF MBP PVALB SLC1A3 TH
45 cytomegalovirus disease in patients with impaired cell mediated immunity deemed at risk 9.1 BDNF CKB ENO2 MBP PVALB SLC1A3

Graphical network of the top 20 diseases related to Neonatal Hypoxic and Ischemic Brain Injury:



Diseases related to Neonatal Hypoxic and Ischemic Brain Injury

Symptoms & Phenotypes for Neonatal Hypoxic and Ischemic Brain Injury

MGI Mouse Phenotypes related to Neonatal Hypoxic and Ischemic Brain Injury:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 BDNF CKB ENO2 MBP PVALB SLC1A3
2 cellular MP:0005384 9.63 BDNF ENO2 MBP PVALB SLC1A3 TH
3 nervous system MP:0003631 9.5 BDNF CKB ENO2 MBP PVALB SLC1A3
4 no phenotypic analysis MP:0003012 8.92 BDNF PVALB SLC1A3 TH

Drugs & Therapeutics for Neonatal Hypoxic and Ischemic Brain Injury

Drugs for Neonatal Hypoxic and Ischemic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium Sulfate Approved, Vet_approved Phase 4,Phase 2,Phase 3 7487-88-9 24083
2
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
3
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
4 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1
5 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
6 Antioxidants Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
7 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
8 Analgesics Phase 4,Phase 2,Phase 3,Phase 1
9 calcium channel blockers Phase 4,Phase 2,Phase 3
10 Tocolytic Agents Phase 4,Phase 2,Phase 3
11 Tocopherols Phase 4
12 Tocotrienols Phase 4
13 Trace Elements Phase 4,Phase 2
14 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
15 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3
16 Vitamins Phase 4,Phase 2
17 Anticonvulsants Phase 4,Phase 2,Phase 3
18 Micronutrients Phase 4,Phase 2
19 Calcium, Dietary Phase 4,Phase 2,Phase 3
20 Tocopherol Nutraceutical Phase 4
21 Tocotrienol Nutraceutical Phase 4
22
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
23
Allopurinol Approved Phase 3 315-30-0 2094
24
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
25
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 5754 657311
26
Butyric Acid Experimental Phase 2, Phase 3 107-92-6 264
27 Epoetin alfa Phase 3,Phase 1,Phase 2 113427-24-0
28 diuretics Phase 3
29 Natriuretic Agents Phase 3
30 Hematinics Phase 3,Phase 1,Phase 2
31 Pharmaceutical Solutions Phase 2, Phase 3,Phase 1
32 Antimetabolites Phase 3
33 Antirheumatic Agents Phase 3
34 Anti-Inflammatory Agents Phase 2, Phase 3
35 glucocorticoids Phase 2, Phase 3
36 Cortisol succinate Phase 2, Phase 3
37 Hydrocortisone 17-butyrate 21-propionate Phase 2, Phase 3
38 Hydrocortisone acetate Phase 2, Phase 3
39 Epinephryl borate Phase 2, Phase 3
40 Hydrocortisone-17-butyrate Phase 2, Phase 3
41 Racepinephrine Phase 2, Phase 3
42
Clonidine Approved Phase 1, Phase 2 4205-90-7 2803
43
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068
44
Darbepoetin alfa Approved, Investigational Phase 1, Phase 2 11096-26-7, 209810-58-2
45
Biotin Approved, Nutraceutical Phase 2 58-85-5 171548
46
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
47 Xenon Phase 1, Phase 2
48 Anesthetics, General Phase 1, Phase 2
49 Anesthetics, Inhalation Phase 1, Phase 2
50 Adrenergic Agents Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 54)
id Name Status NCT ID Phase
1 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4
2 Single High Dose Vitamin C, E in Severe Birth Asphyxia Completed NCT01743742 Phase 4
3 Antenatal Allopurinol During Fetal Hypoxia Unknown status NCT00189007 Phase 3
4 Hypothermia Enhanced by Magnesium Sulphate Completed NCT02499393 Phase 2, Phase 3
5 Whole-Body Cooling for Birth Asphyxia in Term Infants Completed NCT00005772 Phase 3
6 Neonatal Resuscitation in Zambia Completed NCT00097097 Phase 3
7 Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy Recruiting NCT03181646 Phase 3
8 Preemie Hypothermia for Neonatal Encephalopathy Recruiting NCT01793129 Phase 2, Phase 3
9 High-dose Erythropoietin for Asphyxia and Encephalopathy Recruiting NCT02811263 Phase 3
10 Hydrocortisone Treatment In Systemic Low Blood Pressure During Hypothermia in Asphyxiated Newborns Recruiting NCT02700828 Phase 2, Phase 3
11 Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome Not yet recruiting NCT03162653 Phase 3
12 Erythropoietin in Management of Neonatal Hypoxic Ischemic Encephalopathy Not yet recruiting NCT03163589 Phase 3
13 Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth Unknown status NCT01545271 Phase 1, Phase 2
14 Whole Body Cooling Using Phase Changing Material Unknown status NCT01138176 Phase 1, Phase 2
15 Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants Unknown status NCT00910234 Phase 1, Phase 2
16 Systemic Hypothermia Improves Outcome of Hypoxic-Ischemic Encephalopathy Completed NCT00817401 Phase 1, Phase 2
17 Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy Completed NCT00808704 Phase 1, Phase 2
18 Darbe Administration in Newborns Undergoing Cooling for Encephalopathy Completed NCT01471015 Phase 1, Phase 2
19 Erythropoietin in Infants With Hypoxic Ischemic Encephalopathy (HIE) Completed NCT00945789 Phase 1, Phase 2
20 Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia Completed NCT01862250 Phase 1, Phase 2
21 Home Stimulation for Brain-Asphyxiated Infants Completed NCT00006516 Phase 2
22 Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia Completed NCT00934700 Phase 1, Phase 2
23 A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy Recruiting NCT02612155 Phase 2
24 Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth Recruiting NCT02071394 Phase 2
25 Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) Active, not recruiting NCT01913340 Phase 1, Phase 2
26 A Study of 2-Iminobiotin in Neonates With Perinatal Asphyxia Terminated NCT01626924 Phase 2
27 Cord Blood for Neonatal Hypoxic-ischemic Encephalopathy Completed NCT00593242 Phase 1
28 Autologous Cord Blood Cells for Brain Injury in Term Newborns Completed NCT01649648 Phase 1
29 Pilot Study of Head Cooling in Preterm Infants With Hypoxic Ischemic Encephalopathy Completed NCT00620711 Phase 1
30 Sildenafil Administration to Treat Neonatal Encephalopathy Recruiting NCT02812433 Phase 1
31 Hypoxic-Ischemic Encephalopathy Therapy Optimization in Neonates for Better Neuroprotection With Inhalative CO2 Recruiting NCT02700854 Phase 1
32 Phase I Clinical Trial to Determine the Safety of Clonidine in Infants With HIE During Therapeutic Hypothermia. Recruiting NCT02252848 Phase 1
33 Melatonin Treatment for Newborn Infants With Moderate to Severe Hypoxic Ischemic Encephalopathy Withdrawn NCT01904786 Phase 1
34 S100B as a Marker of Brain Injury of Preterm Infants Unknown status NCT02082535
35 Plasma Neutrophil Gelatinase-associated Lipocalin (NGAL) as Early Biomarker for Renal Dysfunction and Good Neurologic Outcome in Out of Hospital Cardiac Arrest Patients Unknown status NCT01987466
36 Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury Completed NCT00375908
37 CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy Completed NCT00383305
38 NeoAdapt 3: Novel Biomarkers in the Evaluation of Neonatal Circulatory Insufficiency in Babies Suffering From Hypoxic Ischemic Encephalopathy Completed NCT02051894
39 Ascorbic Acid and Ibuprofen in Infants With Hypoxic Ischemic Encephalopathy Completed NCT00624871
40 Protein Supplementation in Infants With Brain Injury Completed NCT01936246
41 The TOBY Children Study Completed NCT01092637
42 TOBY (TOtal Body hYpothermia): a Study of Treatment for Perinatal Asphyxia Completed NCT00147030
43 Magnetic Resonance Imaging and Spectroscopy Biomarkers of Neonatal Hypoxic Ischemic Encephalopathy Recruiting NCT01481207
44 Perinatal Brain Injury: Potential of Innovative NIRS to Optimize Hypothermia Recruiting NCT02793999
45 Prospective Research in Infants With Mild Encephalopathy Recruiting NCT01747863
46 Intra-operative Feed Back on Traction Force During Vacuum Extraction: Safe Vacuum Extraction Alliance Recruiting NCT03071783
47 Reno-protective Effect of Brain Cooling in Newborn With Hypoxia Recruiting NCT02683915
48 Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia Recruiting NCT02621944 Early Phase 1
49 Magnetic Resonance Biomarkers in Neonatal Encephalopathy Recruiting NCT01309711
50 The Utility of MRI Scoring to Predict Neurodevelopmental Outcomes in Survivors of Twin-to-Twin Transfusion Syndrome Recruiting NCT02249624

Search NIH Clinical Center for Neonatal Hypoxic and Ischemic Brain Injury

Genetic Tests for Neonatal Hypoxic and Ischemic Brain Injury

Anatomical Context for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards organs/tissues related to Neonatal Hypoxic and Ischemic Brain Injury:

39
Brain

Publications for Neonatal Hypoxic and Ischemic Brain Injury

Variations for Neonatal Hypoxic and Ischemic Brain Injury

Expression for Neonatal Hypoxic and Ischemic Brain Injury

Search GEO for disease gene expression data for Neonatal Hypoxic and Ischemic Brain Injury.

Pathways for Neonatal Hypoxic and Ischemic Brain Injury

Pathways related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.54 BDNF SLC1A3 TH
2 11.43 ENO2 MBP SLC1A3 TH
3 11.05 BDNF MBP
4 11.03 BDNF SLC1A3 TH

GO Terms for Neonatal Hypoxic and Ischemic Brain Injury

Cellular components related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 terminal bouton GO:0043195 9.26 PVALB TH
2 cell periphery GO:0071944 9.16 MBP SLC1A3
3 myelin sheath GO:0043209 9.13 CKB ENO2 MBP
4 neuronal cell body GO:0043025 9.1 CKB ENO2 MBP PVALB SLC1A3 TH

Biological processes related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 substantia nigra development GO:0021762 9.16 CKB MBP
2 response to light stimulus GO:0009416 8.96 SLC1A3 TH
3 sensory perception of sound GO:0007605 8.8 MBP SLC1A3 TH

Molecular functions related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 amino acid binding GO:0016597 8.62 SLC1A3 TH

Sources for Neonatal Hypoxic and Ischemic Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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30 HGMD
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32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
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54 OMIM
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59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
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70 UMLS via Orphanet
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