HIE
MCID: NNT033
MIFTS: 21

Neonatal Hypoxic and Ischemic Brain Injury (HIE) malady

Neuronal category

Summaries for Neonatal Hypoxic and Ischemic Brain Injury

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33MalaCards
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MalaCards: Neonatal Hypoxic and Ischemic Brain Injury, also known as hypoxic-ischemic encephalopathy, is related to hypoxia and west syndrome. An important gene associated with Neonatal Hypoxic and Ischemic Brain Injury is EPO (erythropoietin), and among its related pathways are HIF-1 signaling pathway and HIF-1-alpha transcription factor network. The compounds pimonidazole and cocl2 have been mentioned in the context of this disorder. Affiliated tissues include brain.

Aliases & Classifications for Neonatal Hypoxic and Ischemic Brain Injury

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49Orphanet, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
hypoxic-ischemic encephalopathy:
Inheritance: Sporadic; Prevalence: 1-9/100000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

neonatal hypoxic and ischemic brain injury 49
hypoxic-ischemic encephalopathy 49 61
perinatal asphyxia 49 61
perinatal hypoxia 49 61
hypoxic and ischemic brain injury in the newborn 49
hie 49


Related Diseases for Neonatal Hypoxic and Ischemic Brain Injury

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Neonatal Hypoxic and Ischemic Brain Injury:



Diseases related to neonatal hypoxic and ischemic brain injury

Clinical Features for Neonatal Hypoxic and Ischemic Brain Injury

Drugs & Therapeutics for Neonatal Hypoxic and Ischemic Brain Injury

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neonatal Hypoxic and Ischemic Brain Injury

Anatomical Context for Neonatal Hypoxic and Ischemic Brain Injury

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33MalaCards
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MalaCards organs/tissues related to Neonatal Hypoxic and Ischemic Brain Injury:

33
Brain

Animal Models for Neonatal Hypoxic and Ischemic Brain Injury or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Neonatal Hypoxic and Ischemic Brain Injury

Genetic Variations for Neonatal Hypoxic and Ischemic Brain Injury

Expression for genes affiliated with Neonatal Hypoxic and Ischemic Brain Injury

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neonatal Hypoxic and Ischemic Brain Injury

Search GEO for disease gene expression data for Neonatal Hypoxic and Ischemic Brain Injury.

Pathways for genes affiliated with Neonatal Hypoxic and Ischemic Brain Injury

Sources:
30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 54Reactome
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Compounds for genes affiliated with Neonatal Hypoxic and Ischemic Brain Injury

Sources:
45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB
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Compounds related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1pimonidazole459.3EPO, HIF1A
2cocl2459.3EPO, HIF1A
3cobalt chloride459.3EPO, HIF1A
4fumarate45 1110.3HIF1A, EPO
5deferoxamine45 1110.3EPO, HIF1A
6cobalt45 2410.3EPO, HIF1A
7topotecan45 1110.2EPO, HIF1A
8doxycycline45 1110.2HIF1A, EPO
9celecoxib45 60 29 50 11 2414.2EPO, HIF1A
10carboplatin45 50 1111.1EPO, HIF1A
11mitomycin c459.1EPO, HIF1A
12methotrexate45 50 1111.0HIF1A, EPO
13rapamycin459.0EPO, HIF1A
14ascorbic acid45 249.9EPO, HIF1A
15butyrate458.7EPO, HIF1A

GO Terms for genes affiliated with Neonatal Hypoxic and Ischemic Brain Injury

Sources:
16Gene Ontology
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Biological processes related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to hypoxiaGO:0714569.0EPO, HIF1A
2hemoglobin biosynthetic processGO:0425418.9EPO, HIF1A
3regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614188.7EPO, HIF1A

Products for genes affiliated with Neonatal Hypoxic and Ischemic Brain Injury

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neonatal Hypoxic and Ischemic Brain Injury

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet