MCID: NNT033
MIFTS: 30

Neonatal Hypoxic and Ischemic Brain Injury

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards integrated aliases for Neonatal Hypoxic and Ischemic Brain Injury:

Name: Neonatal Hypoxic and Ischemic Brain Injury 56
Hypoxic-Ischemic Encephalopathy 56 69
Perinatal Asphyxia 56 69
Perinatal Hypoxia 56 69
Hypoxic and Ischemic Brain Injury in the Newborn 56
Encephalopathies Hypoxic-Ischemic 52
Hie 56

Characteristics:

Orphanet epidemiological data:

56
neonatal hypoxic and ischemic brain injury
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: Infancy,Neonatal;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Orphanet 56 ORPHA137577
UMLS via Orphanet 70 C0752304
ICD10 via Orphanet 34 P11.1

Summaries for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards based summary : Neonatal Hypoxic and Ischemic Brain Injury, also known as hypoxic-ischemic encephalopathy, is related to lennox-gastaut syndrome and cerebral palsy, spastic quadriplegic, 1. An important gene associated with Neonatal Hypoxic and Ischemic Brain Injury is ENO2 (Enolase 2), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Neuroscience. The drugs Allopurinol and Mannitol have been mentioned in the context of this disorder. Affiliated tissues include brain and heart, and related phenotypes are behavior/neurological and cellular

Related Diseases for Neonatal Hypoxic and Ischemic Brain Injury

Diseases related to Neonatal Hypoxic and Ischemic Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 47)
id Related Disease Score Top Affiliating Genes
1 lennox-gastaut syndrome 11.1
2 cerebral palsy, spastic quadriplegic, 1 11.0
3 integrative agnosia 10.4 ENO2 MBP
4 submandibular adenitis 10.4 ENO2 MBP
5 pancreatoblastoma 10.4 ENO2 MBP
6 cervical adenomyoma 10.4 ENO2 MBP
7 progressive relapsing multiple sclerosis 10.3 ENO2 MBP
8 extracutaneous mastocytoma 10.3 ENO2 PVALB
9 hypoxia 10.2
10 umbilical hernia 10.2 CKB ENO2
11 rhabdomyosarcoma 2, alveolar 10.2 ENO2 TH
12 kashin-beck disease 10.1 MBP SLC1A3
13 muscular dystrophy, duchenne and becker type 10.0 MBP TH
14 fallopian tube adenomatoid tumor 10.0 BDNF ENO2
15 spinal cord glioma 10.0 ENO2 MBP
16 parietal foramina 3 10.0 MBP TH
17 active cochlear meniere's disease 9.9 BDNF MBP
18 ischemia 9.9
19 late yaws 9.9 BDNF MBP
20 adrenal gland pheochromocytoma 9.9 PVALB TH
21 neuronitis 9.9
22 encephalopathy 9.9
23 leprosy 6 9.8 CKB ENO2
24 west syndrome 9.8 BDNF TH
25 pauci-immune glomerulonephritis with anca 9.7 BDNF TH
26 cerebral palsy 9.7
27 hemolytic-uremic syndrome 9.7
28 kernicterus 9.7
29 neonatal jaundice 9.7 BDNF MBP
30 ovarian cystadenocarcinoma 9.7 BDNF TH
31 hirschsprung disease 1 9.7 BDNF TH
32 ulcerative colitis 9.6 BDNF ENO2 MBP
33 brain meningioma 9.6 BDNF ENO2 MBP
34 personality disorder 9.6 BDNF PVALB
35 idiopathic generalized epilepsy 9.5 BDNF ENO2 PVALB
36 postmenopausal atrophic vaginitis 9.4 BDNF ENO2 TH
37 cystadenoma 9.4 BDNF ENO2 TH
38 osteogenesis imperfecta, type ix 9.4 BDNF SLC1A3
39 partial motor epilepsy 9.4 BDNF TH
40 testicular lymphoma 9.4 BDNF PVALB SLC1A3
41 prostate carcinoma in situ 9.3 BDNF MBP TH
42 hepatic angiomyolipoma 9.3 BDNF MBP TH
43 neuroblastoma 9.3 BDNF ENO2 TH
44 craniosynostosis, adelaide type 9.2 BDNF SLC1A3 TH
45 long qt syndrome 5 8.8 BDNF PVALB SLC1A3 TH
46 schizophrenia 8.3 BDNF MBP PVALB SLC1A3 TH
47 endotheliitis 7.5 BDNF CKB ENO2 MBP PVALB SLC1A3

Graphical network of the top 20 diseases related to Neonatal Hypoxic and Ischemic Brain Injury:



Diseases related to Neonatal Hypoxic and Ischemic Brain Injury

Symptoms & Phenotypes for Neonatal Hypoxic and Ischemic Brain Injury

MGI Mouse Phenotypes related to Neonatal Hypoxic and Ischemic Brain Injury:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 ENO2 MBP PVALB SLC1A3 TH BDNF
2 cellular MP:0005384 9.63 ENO2 MBP PVALB SLC1A3 TH BDNF
3 nervous system MP:0003631 9.5 ENO2 MBP PVALB SLC1A3 TH BDNF
4 no phenotypic analysis MP:0003012 8.92 PVALB SLC1A3 TH BDNF

Drugs & Therapeutics for Neonatal Hypoxic and Ischemic Brain Injury

Drugs for Neonatal Hypoxic and Ischemic Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Allopurinol Approved Phase 3 315-30-0 2094
2
Mannitol Approved, Investigational Phase 3 69-65-8 453 6251
3
Magnesium Sulfate Approved, Vet_approved Phase 2, Phase 3 7487-88-9 24083
4
Choline Approved, Nutraceutical Phase 3 62-49-7 305
5 Antimetabolites Phase 3
6 Antioxidants Phase 3,Phase 1,Phase 2
7 Antirheumatic Agents Phase 3
8 diuretics Phase 3
9 Natriuretic Agents Phase 3
10 Protective Agents Phase 3,Phase 1,Phase 2
11 Anesthetics Phase 2, Phase 3,Phase 1
12 Central Nervous System Depressants Phase 2, Phase 3,Phase 1
13 Analgesics Phase 2, Phase 3,Phase 1
14 Anti-Arrhythmia Agents Phase 2, Phase 3
15 Anticonvulsants Phase 2, Phase 3
16 calcium channel blockers Phase 2, Phase 3
17 Calcium, Dietary Phase 2, Phase 3
18 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 1
19 Tocolytic Agents Phase 2, Phase 3
20 Epoetin alfa Phase 3,Phase 1,Phase 2 113427-24-0
21 Hematinics Phase 3,Phase 1,Phase 2
22 Cytidine Diphosphate Choline Phase 3
23 Nootropic Agents Phase 3
24
Darbepoetin alfa Approved, Investigational Phase 1, Phase 2 11096-26-7, 209810-58-2
25
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068
26
Clonidine Approved Phase 1, Phase 2 4205-90-7 2803
27 Anesthetics, General Phase 1, Phase 2
28 Anesthetics, Inhalation Phase 1, Phase 2
29 Xenon Phase 1, Phase 2
30 Tin Fluorides Phase 1, Phase 2
31 Anti-Asthmatic Agents Phase 1, Phase 2
32 Autonomic Agents Phase 1, Phase 2
33 Bronchodilator Agents Phase 1, Phase 2
34 Endothelium-Dependent Relaxing Factors Phase 1, Phase 2
35 Neurotransmitter Agents Phase 1, Phase 2
36 Respiratory System Agents Phase 1, Phase 2
37 Vasodilator Agents Phase 1, Phase 2
38 Adrenergic Agents Phase 1, Phase 2
39 Adrenergic Agonists Phase 1, Phase 2
40 Adrenergic alpha-2 Receptor Agonists Phase 1, Phase 2
41 Adrenergic alpha-Agonists Phase 1, Phase 2
42 Antihypertensive Agents Phase 1, Phase 2
43 Sympatholytics Phase 1, Phase 2
44 Pharmaceutical Solutions Phase 1
45
Dobutamine Approved 34368-04-2 36811
46
Dopamine Approved 51-61-6, 62-31-7 681
47
Ibuprofen Approved 15687-27-1 3672
48
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
49 Adrenergic beta-Agonists
50 Dopamine Agents

Interventional clinical trials:

(show all 28)

id Name Status NCT ID Phase Drugs
1 Antenatal Allopurinol During Fetal Hypoxia Unknown status NCT00189007 Phase 3 Allopurinol sodium;Mannitol
2 Hypothermia Enhanced by Magnesium Sulphate Completed NCT02499393 Phase 2, Phase 3 Magnesium Sulfate
3 Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy Recruiting NCT03181646 Phase 3 citicoline
4 Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome Not yet recruiting NCT03162653 Phase 3 Allopurinol;Mannitol
5 Erythropoietin in Management of Neonatal Hypoxic Ischemic Encephalopathy Not yet recruiting NCT03163589 Phase 3 Erythropoietin;normal saline
6 Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth Unknown status NCT01545271 Phase 1, Phase 2 xenon gas
7 Systemic Hypothermia Improves Outcome of Hypoxic-Ischemic Encephalopathy Completed NCT00817401 Phase 1, Phase 2
8 Neurological Outcome After Erythropoietin Treatment for Neonatal Encephalopathy Completed NCT00808704 Phase 1, Phase 2 recombinant human erythropoietin
9 Darbe Administration in Newborns Undergoing Cooling for Encephalopathy Completed NCT01471015 Phase 1, Phase 2 Darbepoetin alfa;Darbepoetin alfa;Placebo
10 Erythropoietin in Infants With Hypoxic Ischemic Encephalopathy (HIE) Completed NCT00945789 Phase 1, Phase 2 Human recombinant erythropoietin
11 Safety of Clonidine in Infants With Hypoxic Ischemic Encephalopathy During Therapeutic Hypothermia Completed NCT01862250 Phase 1, Phase 2 Clonidine (Duraclon®)
12 A Multi-site Study of Autologous Cord Blood Cells for Hypoxic Ischemic Encephalopathy Recruiting NCT02612155 Phase 2
13 Xenon and Cooling Therapy in Babies at High Risk of Brain Injury Following Poor Condition at Birth Recruiting NCT02071394 Phase 2 Xenon gas
14 Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) Active, not recruiting NCT01913340 Phase 1, Phase 2 Erythropoietin;Normal saline
15 Cord Blood for Neonatal Hypoxic-ischemic Encephalopathy Completed NCT00593242 Phase 1
16 Autologous Cord Blood Cells for Brain Injury in Term Newborns Completed NCT01649648 Phase 1
17 Melatonin Treatment for Newborn Infants With Moderate to Severe Hypoxic Ischemic Encephalopathy Withdrawn NCT01904786 Phase 1 Melatonin;placebo
18 Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury Completed NCT00375908
19 CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy Completed NCT00383305
20 Prospective Research in Infants With Mild Encephalopathy Completed NCT01747863
21 NeoAdapt 3: Novel Biomarkers in the Evaluation of Neonatal Circulatory Insufficiency in Babies Suffering From Hypoxic Ischemic Encephalopathy Completed NCT02051894 Dobutamine
22 Ascorbic Acid and Ibuprofen in Infants With Hypoxic Ischemic Encephalopathy Completed NCT00624871 Ascorbic acid (vitamin C);Ibuprofen;Placebo
23 Magnetic Resonance Imaging and Spectroscopy Biomarkers of Neonatal Hypoxic Ischemic Encephalopathy Recruiting NCT01481207
24 Perinatal Brain Injury: Potential of Innovative NIRS to Optimize Hypothermia Recruiting NCT02793999
25 Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk Recruiting NCT03246243
26 BiHiVE2 Study. The Investigation and Validation of Predictive Biomarkers in Hypoxic-ischaemic Encephalopathy. Active, not recruiting NCT02019147
27 Hypothermia Therapy in Pediatric Cardiac Intensive Care Unit for Suspected for Brain Injury Not yet recruiting NCT02395276
28 Heart Beat Variability in Neonatal Encephalopathy Not yet recruiting NCT03179553

Search NIH Clinical Center for Neonatal Hypoxic and Ischemic Brain Injury

Genetic Tests for Neonatal Hypoxic and Ischemic Brain Injury

Anatomical Context for Neonatal Hypoxic and Ischemic Brain Injury

MalaCards organs/tissues related to Neonatal Hypoxic and Ischemic Brain Injury:

39
Brain, Heart

Publications for Neonatal Hypoxic and Ischemic Brain Injury

Variations for Neonatal Hypoxic and Ischemic Brain Injury

Expression for Neonatal Hypoxic and Ischemic Brain Injury

Search GEO for disease gene expression data for Neonatal Hypoxic and Ischemic Brain Injury.

Pathways for Neonatal Hypoxic and Ischemic Brain Injury

Pathways related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.54 BDNF SLC1A3 TH
2 11.43 ENO2 MBP SLC1A3 TH
3 11.05 BDNF MBP
4 11.03 BDNF SLC1A3 TH

GO Terms for Neonatal Hypoxic and Ischemic Brain Injury

Cellular components related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 terminal bouton GO:0043195 9.16 PVALB TH
2 neuronal cell body GO:0043025 9.02 CKB MBP PVALB SLC1A3 TH
3 cell periphery GO:0071944 8.96 MBP SLC1A3

Biological processes related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 substantia nigra development GO:0021762 9.16 CKB MBP
2 response to light stimulus GO:0009416 8.96 SLC1A3 TH
3 sensory perception of sound GO:0007605 8.8 MBP SLC1A3 TH

Molecular functions related to Neonatal Hypoxic and Ischemic Brain Injury according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 amino acid binding GO:0016597 8.62 SLC1A3 TH

Sources for Neonatal Hypoxic and Ischemic Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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