MCID: NNT012
MIFTS: 42

Neonatal Jaundice malady

Summaries for Neonatal Jaundice

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Neonatal jaundice or Neonatal hyperbilirubinemia, or Neonatal icterus (from the Greek word... more...

MalaCards: Neonatal Jaundice, also known as jaundice neonatal, is related to kernicterus and gilbert syndrome. An important gene associated with Neonatal Jaundice is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Heme Biosynthesis and heme degradation. The compounds n-acetylbenzidine and sn38 glucuronide have been mentioned in the context of this disorder.

Aliases & Classifications for Neonatal Jaundice

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

neonatal jaundice 8 10 61
jaundice neonatal 45


External Ids:

Disease Ontology8 DOID:2383
MeSH35 D007567

Related Diseases for Neonatal Jaundice

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Neonatal Jaundice via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1kernicterus30.8G6PD, UGT1A9, SLC35A2, RHD, UGT1A7, UGT1A10
2gilbert syndrome30.3UGT1A7, UGT1A1, UGT1A4, G6PD
3pyruvate kinase deficiency30.2G6PD, PKLR
4crigler-najjar syndrome30.0UGT1A4, UGT1A1
5thalassemia30.0G6PD, UGT1A1
6hereditary spherocytosis30.0G6PD, UGT1A1, RHD
7beta thalassemia30.0RHD, UGT1A1, G6PD
8n syndrome10.4
9biliary atresia10.3
10athetosis10.1
11cytomegalic inclusion disease10.1
12sepsis10.1
13burns10.0
14cystic fibrosis10.0
15sensorineural hearing loss10.0
16allergic rhinitis10.0
17sialuria10.0
18hyperargininemia10.0
19rh isoimmunization10.0
20dubin-johnson syndrome10.0
21asthma10.0
22autism spectrum disorder10.0
23blood group incompatibility10.0
24toxoplasmosis10.0
25char syndrome10.0
26clostridium difficile10.0
27septo-optic dysplasia10.0
28breast/ovarian cancer, hereditary: brca1/brca2/additional genes sequence analysis multi-gene panels10.0
29cytomegalovirus infection10.0
30hepatitis10.0UGT1A1
31liver cirrhosis10.0BTD
32cholelithiasis10.0UGT1A1, UGT1A6
33crigler najjar syndrome, type 210.0UGT1A4, UGT1A1
34congenital nonspherocytic hemolytic anemia10.0PKLR, G6PD
35cholestasis10.0HSD3B7, CIRH1A
36neutropenia10.0UGT1A1, UGT1A6
37congenital hemolytic anemia10.0PKLR, G6PD
38bilirubin metabolic disorder10.0G6PD, UGT1A1, UGT1A7
39deficiency anemia10.0G6PD, RHD, PKLR
40hereditary elliptocytosis10.0G6PD, RHD
41glucosephosphate dehydrogenase deficiency10.0G6PD, PKLR
42diarrhea10.0UGT1A6, UGT1A1
43alpha thalassemia10.0UGT1A1, G6PD
44sickle cell disease10.0BTD, RHD, UGT1A1, G6PD
45hemolytic anemia10.0PKLR, RHD, UGT1A1, G6PD
46phenylketonuria10.0BTD, G6PD
47galactosemia10.0HSD3B7, G6PD, UGT1A1, BTD
48hemoglobinopathy10.0G6PD, BTD
49colorectal cancer10.0OSM, UGT1A9, UGT1A6, UGT1A1, UGT1A7
50colon cancer10.0UGT1A10, UGT1A1, OSM

Graphical network of the top 20 diseases related to Neonatal Jaundice:



Diseases related to neonatal jaundice

Clinical Features for Neonatal Jaundice

Drugs & Therapeutics for Neonatal Jaundice

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Neonatal Jaundice

Drug clinical trials:

Search ClinicalTrials for Neonatal Jaundice

Search NIH Clinical Center for Neonatal Jaundice

Search CenterWatch for Neonatal Jaundice

Genetic Tests for Neonatal Jaundice

Anatomical Context for Neonatal Jaundice

Animal Models for Neonatal Jaundice or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Neonatal Jaundice

Sources:
51PubMed
See all sources

Articles related to Neonatal Jaundice:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Neonatal jaundice and its management: knowledge, attitude, and practice among expectant mothers attending antenatal clinic at University of Benin Teaching Hospital, Benin City, Nigeria. (23563460)
2013
2
Treatment of neonatal jaundice with filtered sunlight in Nigerian neonates: study protocol of a non-inferiority, randomized controlled trial. (24373547)
2013
3
Applying data mining techniques to improve diagnosis in neonatal jaundice. (23216895)
2012
4
Neonatal jaundice is a risk factor for childhood asthma: a retrospective cohort study. (22957782)
2012
5
Baby massage ameliorates neonatal jaundice in full-term newborn infants. (21263210)
2011
6
Intractable neonatal jaundice due to hereditary spherocytosis and Gilbert's syndrome. (22689841)
2011
7
Assessment of UGT polymorphisms and neonatal jaundice. (21641485)
2011
8
The Effect of Traditional Remedies (Camel's Thorn, Flixweed and Sugar Water) on Idiopathic Neonatal Jaundice. (23056809)
2011
9
Effect of neonatal jaundice and phototherapy on the frequency of first-year outpatient visits. (20231183)
2010
10
Neonatal jaundice--are we over-treating? (20222394)
2010
11
Neonatal adrenal hemorrhage presenting as late onset neonatal jaundice. (20419026)
2009
12
Does circumcision increase neonatal jaundice? (18616632)
2008
13
Readmission for neonatal jaundice in California, 1991-2000: trends and implications. (18381515)
2008
14
Neonatal jaundice and bilirubin UDP-glucuronosyl transferase 1A1 gene polymorphism in Turkish patients. (16623861)
2006
15
In vitro and in vivo efficacy of new blue light emitting diode phototherapy compared to conventional halogen quartz phototherapy for neonatal jaundice. (15716604)
2005
16
Immunizations, neonatal jaundice, and animal-induced injuries. (15273509)
2004
17
A primer on neonatal jaundice. (15366777)
2004
18
Different anesthesiologic strategies have no effect on neonatal jaundice. (14997325)
2004
19
Neonatal jaundice and urinary tract infections. (14595074)
2003
20
Neonatal jaundice coinciding with or resulting from urinary tract infections? (14595073)
2003
21
Interest in the study of genetic variants of the promoter region of the UGT1A1 gene in neonatal jaundice]. (11827650)
2002
22
Alternative metalloporphyrins for the treatment of neonatal jaundice. (11803430)
2001
23
Neonatal jaundice and kernicterus. (11533348)
2001
24
Is breastfeeding really favoring early neonatal jaundice? (11230622)
2001
25
Managing the assessment of neonatal jaundice: importance of timing. (11105424)
2000
26
Comparison technetium of Tc-99m disofenin cholescintigraphy with ultrasonography in the differentiation of biliary atresia from other forms of neonatal jaundice. (9035206)
1997
27
Validating assessment of neonatal jaundice with transcutaneous bilirubin measurement. (8716526)
1996
28
Etiology of neonatal jaundice at Shimla. (7875794)
1994
29
Effect of phototherapy for neonatal jaundice on cognitive performance. (8169674)
1994
30
Treating neonatal jaundice with phenobarbitone: the inadvertant administration of significant doses of ethyl alcohol. (1739339)
1992
31
Screening for glucose-6-phosphate dehydrogenase deficiency can prevent severe neonatal jaundice. (1283668)
1992
32
Epidemiologic study of neonatal jaundice. A survey of contributing factors. (2642257)
1989
33
Dr John Burns (1774-1850) and neonatal jaundice. (2686557)
1989
34
Neonatal jaundice in 'healthy' very low birthweight infants. (3662981)
1987
35
Neonatal jaundice: current concepts. (3822013)
1987
36
Risk factors and sib correlation in physiological neonatal jaundice. (3604669)
1987
37
Sunburn from the treatment of neonatal jaundice. (3719406)
1986
38
Neonatal jaundice: its prevalence in Chinese babies and associating factors. (3767789)
1986
39
Cholestatic neonatal jaundice. (3769989)
1986
40
A survey of neonatal jaundice in association with household drugs and chemicals in Nigeria. (2418773)
1985
41
Neonatal jaundice: investigation and monitoring. (3890680)
1985
42
The natural history of neonatal jaundice. (6472969)
1984
43
Phototherapy for neonatal jaundice: in vitro comparison of light sources. (6540860)
1984
44
Cord blood transferrin/alpha-fetoprotein ratios: a predictive index for neonatal jaundice. (6189690)
1983
45
Effectiveness and safety of prenatal phenobarbital for the prevention of neonatal jaundice. (7422399)
1980
46
Some practical aspects of neonatal jaundice. (612581)
1977
47
Neonatal jaundice in association with oxytocin stimulation of labour and operative delivery. (942873)
1976
48
A laboratory survey of A-B-O blood-group incompatibility and neonatal jaundice. (5387801)
1969
49
PATTERN OF SERUM TRANSAMINASE ACTIVITY IN NEONATAL JAUNDICE DUE TO CYTOMEGALIC INCLUSION DISEASE AND TOXOPLASMOSIS WITH HEPATIC INVOLVEMENT. (14074424)
1963
50
Neonatal jaundice and kernicterus. (13157632)
1954

Genetic Variations for Neonatal Jaundice

Expression for genes affiliated with Neonatal Jaundice

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Neonatal Jaundice

Search GEO for disease gene expression data for Neonatal Jaundice.

Pathways for genes affiliated with Neonatal Jaundice

Sources:
38NCBI BioSystems Database, 54Reactome, 50PharmGKB, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Neonatal Jaundice according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2UGT1A1, HMOX2
2
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10.2HMOX2, UGT1A1
3
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10.2UGT1A10, UGT1A4
4
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10.2UGT1A1, UGT1A9
5
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10.2UGT1A1, UGT1A8
6
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10.2UGT1A9, UGT1A4
710.2UGT1A9, UGT1A4
8
Hide members
10.2G6PD, BPNT1
9
Saturated fatty acid biosynthesis
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10.2BTD, PKLR
1010.0UGT1A3, UGT1A10, UGT1A8
11
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10.0UGT1A9, UGT1A10, UGT1A6
12
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9.9UGT1A1, UGT1A3, UGT1A10, UGT1A9
13
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9.9UGT1A9, UGT1A1, UGT1A6, UGT1A4
14
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9.6UGT1A3, UGT1A10, UGT1A1, UGT1A8, UGT1A4, UGT1A9
15
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9.5UGT1A1, UGT1A3, UGT1A4, UGT1A8, UGT1A6, UGT1A9
169.5UGT1A9, UGT1A3, UGT1A10, UGT1A6, UGT1A8, UGT1A4
17
Acetaminophen metabolism
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9.4UGT1A8, UGT1A9, UGT1A4, UGT1A3, UGT1A10, UGT1A6
18
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9.2UGT1A4, UGT1A8, UGT1A6, UGT1A7, UGT1A1, UGT1A10
19
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9.1UGT1A3, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1
20
Hide members
9.1UGT1A9, UGT1A8, UGT1A6, UGT1A1, UGT1A5, UGT1A10
21
Hide members
8.9UGT1A3, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1
22
Hide members
8.4BPNT1, UGT1A9, UGT1A8, UGT1A6, UGT1A1, UGT1A5

Compounds for genes affiliated with Neonatal Jaundice

Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 50PharmGKB, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Neonatal Jaundice according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1n-acetylbenzidine4510.4UGT1A4, UGT1A9, UGT1A1
2sn38 glucuronide4510.3UGT1A7, UGT1A1, UGT1A9
3acetaminophen glucuronide45 2411.3UGT1A1, UGT1A6, UGT1A9
4Ezogabine 1110.3UGT1A1, UGT1A9, UGT1A4, UGT1A3
5lamotrigine45 1111.3UGT1A1, UGT1A4, UGT1A6, UGT1A3
64-methylumbelliferone4510.2UGT1A6, UGT1A1, UGT1A9
71-naphthol4510.2UGT1A6, UGT1A9, UGT1A1
8udp glucuronic acid4510.2UGT1A8, UGT1A6, UGT1A10, UGT1A1
9benzidine4510.2UGT1A6, UGT1A1, UGT1A9, UGT1A4
10n-hydroxy-n-acetylbenzidine4510.2UGT1A9, UGT1A4
11phenol45 2411.2G6PD, UGT1A1, UGT1A6, UGT1A9
12trifluoperazine45 29 1112.2UGT1A4, UGT1A9, UGT1A6, UGT1A1
13etodolac45 1111.1UGT1A9, UGT1A10, UGT1A3
14p-nitrophenol45 1111.1UGT1A9, UGT1A3, UGT1A4, UGT1A1, UGT1A6
15mycophenolic acid45 50 1112.1UGT1A9, UGT1A8, UGT1A1, UGT1A10, UGT1A7
16diclofenac45 29 50 1113.1UGT1A3, UGT1A1, UGT1A6, UGT1A4, UGT1A9
17mycophenolate mofetil45 50 1112.1UGT1A8, UGT1A10, UGT1A1, UGT1A9
18phip4510.0UGT1A9, UGT1A1, UGT1A4
19benzo(a)pyrene4510.0UGT1A1, UGT1A6, UGT1A7, UGT1A9
20uridine45 11 2412.0UGT1A6, UGT1A4, UGT1A9, UGT1A1, UGT1A7
21irinotecan45 50 1112.0UGT1A9, UGT1A7, UGT1A1, UGT1A6
22amine4510.0UGT1A3, UGT1A1, UGT1A7, UGT1A4
23flurbiprofen45 29 50 1112.9UGT1A1, UGT1A3, UGT1A9
24morphine45 50 29 1112.9UGT1A1, UGT1A9, UGT1A8, UGT1A6, UGT1A4, UGT1A3
25tamoxifen45 50 29 1112.9UGT1A1, G6PD, UGT1A9, UGT1A4, UGT1A6, UGT1A3
26glucuronide459.9UGT1A3, UGT1A7, UGT1A9, UGT1A4, UGT1A6, UGT1A1
27acetaminophen45 2 50 11 2413.9G6PD, UGT1A1, UGT1A4, UGT1A9, UGT1A6, UGT1A10
28uridine diphosphate459.8UGT1A9, UGT1A7, UGT1A3, UGT1A10, UGT1A1, UGT1A6
29n-hydroxy phip459.8UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
30propofol45 50 1111.8UGT1A4, UGT1A9, UGT1A6, UGT1A1, UGT1A10, UGT1A8
31troglitazone45 29 60 1112.8UGT1A4, UGT1A1, UGT1A3, UGT1A10, UGT1A6, UGT1A8
32buprenorphine45 29 1111.7UGT1A9, UGT1A1, UGT1A3
33ethyl glucuronide45 2410.7UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10, UGT1A7
34cotinine45 2410.7UGT1A9, UGT1A8, UGT1A1, UGT1A6, UGT1A10, UGT1A7
35imipramine45 50 29 11 2413.7UGT1A4, UGT1A6, UGT1A7, UGT1A9, UGT1A1, UGT1A8
36nicotine45 50 29 1112.6UGT1A4, UGT1A8, UGT1A9, UGT1A1, UGT1A10, UGT1A7
37androsterone glucuronide45 2410.6UGT1A5, UGT1A10, UGT1A7, UGT1A3, UGT1A1, UGT1A6
383-alpha-androstanediol glucuronide45 2410.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
39etiocholanolone45 2410.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
40estriol29 11 2411.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
41estrone45 29 11 2412.6UGT1A7, UGT1A3, UGT1A10, UGT1A5, UGT1A1, UGT1A9
422-methoxyestradiol45 60 2411.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
43(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)249.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
44bilirubin diglucuronide45 2410.6UGT1A10, UGT1A7, UGT1A3, UGT1A5, UGT1A1, UGT1A6
45aldosterone 18-glucuronide45 2410.5UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
46codeine45 50 29 11 2413.5UGT1A3, UGT1A7, UGT1A9, UGT1A4, UGT1A8, UGT1A6
47valproic acid45 50 11 2412.5UGT1A3, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
48testosterone45 60 11 2412.4UGT1A7, UGT1A9, UGT1A10, UGT1A3, G6PD, UGT1A4
49estradiol45 11 2411.3UGT1A6, UGT1A9, UGT1A8, UGT1A4, UGT1A7, UGT1A1
50retinoic acid45 2410.3UGT1A9, UGT1A8, UGT1A3, UGT1A4, UGT1A6, UGT1A1

GO Terms for genes affiliated with Neonatal Jaundice

Sources:
16Gene Ontology
See all sources

Cellular components related to Neonatal Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular membrane-bounded organelleGO:0432319.4UGT1A9, UGT1A8, UGT1A6, UGT1A5, G6PD
2integral to membraneGO:0160218.8UGT1A10, SLC35A2, TAAR8, UGT1A7, HSD3B7, UGT1A9
3endoplasmic reticulum membraneGO:0057898.8HMOX2, HSD3B7, UGT1A9, UGT1A4, UGT1A8, UGT1A6

Biological processes related to Neonatal Jaundice according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1porphyrin-containing compound metabolic processGO:00677810.2HMOX2, UGT1A1
2negative regulation of steroid metabolic processGO:04593910.2UGT1A8, UGT1A1
3cellular glucuronidationGO:05269510.1UGT1A4, UGT1A6, UGT1A1, UGT1A10
4negative regulation of fatty acid metabolic processGO:04592210.1UGT1A9, UGT1A8, UGT1A7
5coumarin metabolic processGO:00980410.0UGT1A7, UGT1A8
6negative regulation of catalytic activityGO:04308610.0UGT1A7, UGT1A1, UGT1A8, UGT1A9
7flavone metabolic processGO:05155210.0UGT1A7, UGT1A9, UGT1A8, UGT1A1, UGT1A10
8xenobiotic glucuronidationGO:05269710.0UGT1A9, UGT1A8, UGT1A1, UGT1A7, UGT1A3
9flavonoid glucuronidationGO:05269610.0UGT1A9, UGT1A8, UGT1A1, UGT1A7, UGT1A3
10retinoic acid metabolic processGO:04257310.0UGT1A9, UGT1A8, UGT1A1, UGT1A7, UGT1A3
11drug metabolic processGO:01714410.0UGT1A7, UGT1A1, UGT1A8, UGT1A9
12metabolic processGO:0081529.9UGT1A3, UGT1A10, UGT1A5, UGT1A6, UGT1A9
13heme catabolic processGO:0421679.9HMOX2, UGT1A1
14xenobiotic metabolic processGO:0068059.7BPNT1, UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A5
15small molecule metabolic processGO:0442819.1UGT1A9, G6PD, BPNT1, HSD3B7, UGT1A4, UGT1A6

Molecular functions related to Neonatal Jaundice according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00549610.2UGT1A8, UGT1A1
2enzyme inhibitor activityGO:0048579.5UGT1A9, UGT1A8, UGT1A1, UGT1A7
3retinoic acid bindingGO:0019729.4UGT1A3, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1
4enzyme bindingGO:0198999.3UGT1A10, UGT1A1, UGT1A6, UGT1A8, UGT1A4, UGT1A9
5glucuronosyltransferase activityGO:0150209.2UGT1A7, UGT1A3, UGT1A5, UGT1A1, UGT1A6, UGT1A8
6protein heterodimerization activityGO:0469829.2UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10, UGT1A7
7protein homodimerization activityGO:0428039.1G6PD, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1

Products for genes affiliated with Neonatal Jaundice

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neonatal Jaundice

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet