MCID: NNT012
MIFTS: 51

Neonatal Jaundice

Categories: Fetal diseases, Skin diseases

Aliases & Classifications for Neonatal Jaundice

Summaries for Neonatal Jaundice

Disease Ontology : 12 A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant.

MalaCards based summary : Neonatal Jaundice, also known as hyperbilirubinemia, neonatal, is related to pyruvate kinase deficiency of red cells and kernicterus, and has symptoms including newborn physiological jaundice and icterus. An important gene associated with Neonatal Jaundice is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways are Porphyrin and chlorophyll metabolism and Phenytoin Pathway, Pharmacokinetics. The drugs Pyrimethamine and Sulfadoxine have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and breast.

Wikipedia : 72 Neonatal jaundice is a yellowish discoloration of the white part of the eyes and skin in a newborn baby... more...

Related Diseases for Neonatal Jaundice

Diseases related to Neonatal Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 pyruvate kinase deficiency of red cells 32.3 G6PD PKLR
2 kernicterus 32.3 G6PD UGT1A1
3 glucosephosphate dehydrogenase deficiency 29.7 G6PD SLCO1B1 UGT1A1
4 gilbert syndrome 29.7 G6PD SLCO1B1 UGT1A1
5 hereditary spherocytosis 28.9 G6PD PKLR SPTA1 UGT1A1
6 bilirubin metabolic disorder 28.9 G6PD HMOX1 NR1I3 SLCO1B1 UGT1A1
7 sialuria 11.0
8 bile acid synthesis defect, congenital, 4 10.8
9 anemia, nonspherocytic hemolytic, due to g6pd deficiency 10.8
10 immunodeficiency 47 10.8
11 north american indian childhood cirrhosis 10.8
12 bile acid synthesis defect, congenital, 1 10.8
13 peroxisome biogenesis disorder 10b 10.8
14 congenital nonspherocytic hemolytic anemia 10.4 G6PD PKLR
15 hyperbilirubinemia, transient familial neonatal 10.4
16 back pain 10.3 G6PD IL6
17 plasmodium vivax malaria 10.2 G6PD IL6
18 arteriovenous fistula 10.2 HMOX1 IL6
19 irinotecan toxicity 10.2 SLCO1B1 UGT1A1
20 pigmentation disease 10.2 SLCO1B1 UGT1A1
21 sickle cell disease 10.2 G6PD UGT1A1
22 nodular malignant melanoma 10.1 HMOX1 HMOX2
23 pulmonary disease, chronic obstructive 10.1 HMOX1 IL6
24 senile cataract 10.1 G6PD GSTM1
25 ischemic optic neuropathy 10.0 G6PD GSTM1
26 asbestosis 10.0 GSTM1 IL6
27 congenital hemolytic anemia 9.9 G6PD PKLR
28 biliary atresia 9.9
29 intrahepatic cholestasis 9.9 NR1I3 SLCO1B1 UTP4
30 cholestasis 9.9 NR1I3 SLCO1B1 UTP4
31 autism 9.8
32 aging 9.8
33 pneumoconiosis 9.8 GSTM1 IL6
34 toxic encephalopathy 9.8 GSTM1 HMOX1
35 alpha-fetoprotein deficiency 9.8
36 burns 9.8
37 hepatitis 9.8
38 athetosis 9.8
39 cytomegalic inclusion disease 9.8
40 hemolytic anemia 9.7 G6PD PKLR SPTA1
41 malaria 9.7 G6PD HMOX1 IL6 PKLR
42 cataract 5, multiple types 9.6
43 fibrosis of extraocular muscles, congenital, 1 9.6
44 attention deficit-hyperactivity disorder 9.6
45 septooptic dysplasia 9.6
46 crigler-najjar syndrome, type i 9.6
47 cystic fibrosis 9.6
48 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.6
49 dubin-johnson syndrome 9.6
50 asthma 9.6

Graphical network of the top 20 diseases related to Neonatal Jaundice:



Diseases related to Neonatal Jaundice

Symptoms & Phenotypes for Neonatal Jaundice

UMLS symptoms related to Neonatal Jaundice:


newborn physiological jaundice, icterus

Drugs & Therapeutics for Neonatal Jaundice

Drugs for Neonatal Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pyrimethamine Approved, Investigational, Vet_approved Phase 4 58-14-0 4993
2
Sulfadoxine Approved, Investigational Phase 4 2447-57-6 17134
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
4
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
5 Anti-Infective Agents Phase 4,Phase 2
6 Antimalarials Phase 4
7 Antiparasitic Agents Phase 4
8 Antiprotozoal Agents Phase 4
9 Fanasil, pyrimethamine drug combination Phase 4
10 Folic Acid Antagonists Phase 4
11 Renal Agents Phase 4
12 Vitamin B Complex Phase 4
13 Folate Nutraceutical Phase 4
14 Vitamin B9 Nutraceutical Phase 4
15
Tin Phase 3,Phase 2 7440-31-5
16 Tin mesoporphyrin Phase 3,Phase 2
17
Zinc Approved, Investigational Phase 1, Phase 2 7440-66-6 32051 23994
18
Ceftriaxone Approved Phase 2 73384-59-5 5479530 5361919
19 Antioxidants Phase 1, Phase 2
20
Bilirubin Phase 1, Phase 2 635-65-4 5280352
21 Micronutrients Phase 1, Phase 2
22 Protective Agents Phase 1, Phase 2
23 Trace Elements Phase 1, Phase 2
24 Anti-Bacterial Agents Phase 2
25
Menthol Approved 2216-51-5 16666
26
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
27
Glycerol Approved, Investigational 56-81-5 753
28
Glyburide Approved 10238-21-8 3488
29
Metformin Approved 657-24-9 4091 14219
30
Protein C Approved
31
Iron Approved 7439-89-6 23925
32 tannic acid Approved, Nutraceutical
33 Antibodies, Anti-Idiotypic
34 Hypoglycemic Agents
35 insulin
36 Insulin, Globin Zinc
37 Alpha 1-Antitrypsin
38 HIV Protease Inhibitors
39
protease inhibitors
40 Protein C Inhibitor
41 Serine Proteinase Inhibitors
42 Trypsin Inhibitors
43 Pharmaceutical Solutions
44 Acidophilus Nutraceutical
45 serine Nutraceutical

Interventional clinical trials:

(show all 42)

# Name Status NCT ID Phase Drugs
1 Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia Completed NCT00270530 Phase 4 Sulfadoxine-pyrimethamine (Fansidar)
2 Efficacy and Safety of Stannsoporfin in Neonates Completed NCT02685137 Phase 3 stannsoporfin
3 Efficacy and Safety of Probiotics in Neonatal Hyperbilirubinemia Recruiting NCT03266913 Phase 3 Probiotic
4 Treatment of Neonatal Jaundice With Filtered Sunlight Phototherapy: Safety and Efficacy in African Neonates Completed NCT01434810 Phase 1, Phase 2
5 Efficacy of Zinc in Reducing Hyperbilirubinemia Among High Risk Neonates - A Double Blind Randomized Trial Completed NCT00692224 Phase 1, Phase 2 zinc gluconate;placebo
6 Study Evaluating the Safety and Efficacy of Two Doses of Stannsoporfin in Combination With Phototherapy in Neonates With Hyperbilirubinemia Completed NCT01887327 Phase 2 stannsoporfin;Placebo
7 Filtered Sunlight Phototherapy to Treat Significant Jaundice: Safety and Efficacy in Neonates Completed NCT02612727 Phase 1, Phase 2
8 Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants Completed NCT01081977 Phase 2
9 Ceftriaxone and Jaundice in Neonates Recruiting NCT03133637 Phase 2 ceftriaxone
10 Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment. Unknown status NCT02224586
11 Study on Newborn Babies With a Yellow Skin Color (Neonatal Jaundice Study) Unknown status NCT02361788
12 Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis Unknown status NCT00917007
13 Neonatal Jaundice: Knowledge, Attitudes and Practices of Mothers and Medical Trainees and Providers in and Around Ogbomosho Completed NCT03306004
14 Evaluation of a Smartphone Based Optical Diagnostic Tool for Neonatal Jaundice Completed NCT03007563
15 Implementation of a Transcutaneous Bilirubinometer Completed NCT01622699
16 Comparison Between Turquoise and Blue Light in Treatment of Neonatal Jaundice Using Light Emission Diodes Completed NCT02154165
17 Transcutaneous Screening for Risk of Severe Hyperbilirubinemia in South African Newborns Completed NCT02613676
18 BEST ABCs: Benefits and Effectiveness of Support Offered Through A Breastfeeding Clinic Study Completed NCT02043119
19 The Risk of Hyperbilirubinemia in Term Newborns After Placental Transfusion Completed NCT02625688
20 Does Maternal Instruction Prevent Kernicterus in Nigeria? Completed NCT02713464
21 Transcutaneous Measurement of Jaundice in the Newborn Completed NCT01169740
22 Clinical and Developmental Outcomes of Babies Who Became Yellow in the First Month of Life Completed NCT02927093
23 Glycerin Suppositories to Reduce Jaundice in Premature Infants Completed NCT01746511 glycerin suppository
24 Effects of Probiotics on Neonatal Hyperbilirubinemia Completed NCT02807246
25 Transcutaneous Bilirubinometers in the Community Completed NCT00735319
26 Determining Prevalence of Acute Bilirubin Encephalopathy in Developing Countries Completed NCT01754688
27 Evaluating the Effects of SMS Text Messaging Support System Among Frontline Health Workers in Ghana Completed NCT02468310
28 Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. Systematic Review Completed NCT01998113 Glyburide vs Insulin trials;Metformin vs Insulin trials;Metformin vs Glyburide trials
29 Umbilical Cord Milking on the Reduction of Red Blood Cell Transfusion Rates in Infants Completed NCT01523769
30 A Trial of the Irradiance Level of Phototherapy for Neonatal Jaundice Recruiting NCT03055481
31 Comparison of the Efficacy of Phototherapy Using Blue LED's With Wavelength 478 vs. 459 nm. Recruiting NCT03183986
32 Implementation of a Clinical Decision Rule for Treatment of Neonatal Jaundice in the Emergency Department Recruiting NCT02446951
33 Unbound Bilirubin Levels in Healthy Term and Late Preterm Infants Recruiting NCT03237715
34 Efficacy Study of the Draeger Jaundice Meter (JM-105) in Neonates of ≥ 24 Weeks of Gestational Age Recruiting NCT02774434
35 Polygen Defi-Alpha: Genetic Polymorphisms Study in Children With Alpha-1 Antitrypsin Deficiency, Included in the DEFI-ALPHA Cohort Recruiting NCT01862211
36 Cycled Phototherapy: A Safer Effective Treatment for Small Premature Infants? Recruiting NCT01944696
37 Group Versus Traditional Prenatal Care for Diabetes Recruiting NCT03301792
38 Intrapartum Glucose and Insulin Compared to Glucose Alone in Diabetic Women Recruiting NCT03273881 glucose solution and Insulin;glucose solution only
39 Effect of Umbilical Cord Milking on Iron Related Health Outcomes for Cesarean-Delivered Infants Recruiting NCT02892461
40 Understanding Neonatal Jaundice in Rwanda Active, not recruiting NCT03184948
41 Effect of Timing of Umbilical Cord Clamping on Anaemia at 8 and 12 Months and Later Neurodevelopment Active, not recruiting NCT02222805
42 Compassionate Use of Stanate (TM) [Stannsoporfin] No longer available NCT00076960 Stanate (TM) [stannsoporfin, tin-mesoporphyrin]

Search NIH Clinical Center for Neonatal Jaundice

Cochrane evidence based reviews: jaundice, neonatal

Genetic Tests for Neonatal Jaundice

Anatomical Context for Neonatal Jaundice

MalaCards organs/tissues related to Neonatal Jaundice:

38
Skin, Eye, Breast, Liver, Brain, Colon

Publications for Neonatal Jaundice

Articles related to Neonatal Jaundice:

(show top 50) (show all 586)
# Title Authors Year
1
The Contribution of Neonatal Jaundice to Global Child Mortality: Findings From the GBD 2016 Study. ( 29305393 )
2018
2
Yinzhihuang oral liquid in the treatment of neonatal jaundice: a meta-analysis. ( 27937684 )
2017
3
Primary health workers' knowledge and practices relating to neonatal jaundice in Ibadan, Nigeria. ( 28155287 )
2017
4
The lowering of bilirubin levels in patients with neonatal jaundice using massage therapy: A randomized, double-blind clinical trial. ( 28688960 )
2017
5
Umbilical cord bilirubin as a predictor of neonatal jaundice: a retrospective cohort study. ( 28931391 )
2017
6
Neonatal jaundice: aetiology, diagnosis and treatment. ( 29240507 )
2017
7
Phototherapy is commonly used for neonatal jaundice but greater control is needed to avoid toxicity in the most vulnerable infants. ( 29119603 )
2017
8
Sensitivity, Specificity, and Accuracy of Kramer Examination of Neonatal Jaundice: Comparison with Total Bilirubin Serum. ( 29166181 )
2017
9
Ocular findings on follow-up in children who received phototherapy for neonatal jaundice. ( 28919296 )
2017
10
The influence of zinc sulfate on neonatal jaundice: a systematic review and meta-analysis. ( 28372469 )
2017
11
Maternal detection of neonatal jaundice during birth hospitalization using a novel two-color icterometer. ( 28837635 )
2017
12
Nursing Diagnosis of Neonatal Jaundice: Study of Clinical Indicators. ( 29248302 )
2017
13
Clinical practices among healthcare professionals concerning neonatal jaundice and pale stools. ( 28083674 )
2017
14
Filtered sunlight, solar powered phototherapy and other strategies for managing neonatal jaundice in low-resource settings. ( 28919246 )
2017
15
Uniform national guidelines do not prevent wide variations in the clinical application of phototherapy for neonatal jaundice. ( 29119594 )
2017
16
Neonatal jaundice: more than a number. ( 28343534 )
2017
17
Point-of-care device to diagnose and monitor neonatal jaundice in low-resource settings. ( 29203650 )
2017
18
Probiotics Supplementation Therapy for Pathological Neonatal Jaundice: A Systematic Review and Meta-Analysis. ( 28713275 )
2017
19
Use of a Smartphone App to Assess Neonatal Jaundice. ( 28842403 )
2017
20
Association Between Early Idiopathic Neonatal Jaundice and Urinary Tract Infections. ( 28469520 )
2017
21
Correspondence: Hordeum Vulgare in Neonatal Jaundice. ( 28969234 )
2017
22
Severe neonatal jaundice due to a de novo glucose-6-phosphate dehydrogenase deficient mutation. ( 26693676 )
2016
23
Haemolytic and non-haemolytic neonatal jaundice have different risk factor profiles. ( 27173507 )
2016
24
Cotoneaster and Neonatal Jaundice. ( 27891418 )
2016
25
Neonatal jaundice. ( 27353908 )
2016
26
Gene Mutation in Neonatal Jaundice - Mutations in UGT1A1 and OATP2 Genes. ( 26960716 )
2016
27
50 Years Ago in The Journal of Pediatrics: Studies of Prolonged Neonatal Jaundice in the Breast-Fed Infant. ( 26719182 )
2016
28
Management of neonatal jaundice in primary care. ( 28461853 )
2016
29
A Pilot Metabolic Profiling Study of Patients With Neonatal Jaundice and Response to Phototherapy. ( 27306191 )
2016
30
Kernicterus in Neonatal Jaundice-Finding the Needle in the Haystack. ( 26945202 )
2016
31
Neonatal Jaundice Detection System. ( 27229489 )
2016
32
Perceptions, practices, and traditional beliefs related to neonatal jaundice among Egyptian mothers: A cross-sectional descriptive study. ( 27603393 )
2016
33
The role of UGT1A1 promoter polymorphism and exon-1 mutations in neonatal jaundice. ( 27842454 )
2016
34
Prolonged neonatal jaundice and urinary tract infection. ( 27989001 )
2016
35
Cotoneaster: A Safe and Easy Way to Reduce Neonatal Jaundice. ( 27190910 )
2016
36
Neonatal jaundice. ( 27387624 )
2016
37
The effect of Cotoneaster manna on neonatal jaundice: A PRISMA-compliant systematic review. ( 27976153 )
2016
38
Effect of phototherapy on B and T lymphocytes in Egyptian infants suffering from neonatal jaundice. ( 27890454 )
2016
39
A Survey of Practice and Knowledge of Refugee and Migrant Pregnant Mothers Surrounding Neonatal Jaundice on the Thailand-Myanmar Border. ( 27576869 )
2016
40
Phototherapy for the Treatment of Neonatal Jaundice and Breastfeeding Duration and Exclusivity. ( 27057645 )
2016
41
Risk profiles for haemolytic and nonhaemolytic neonatal jaundice. ( 27870210 )
2016
42
The burden and management of neonatal jaundice in Nigeria: A scoping review of the literature. ( 26755212 )
2016
43
Neonatal Jaundice in Low- and Middle-Income Countries: Lessons and Future Directions from the 2015 Don Ostrow Trieste Yellow Retreat. ( 27172942 )
2016
44
Effects of baby massage on neonatal jaundice in healthy Iranian infants: A pilot study. ( 26646074 )
2016
45
Neonatal Jaundice with Splenomegaly: Not a Common Pick. ( 26847548 )
2016
46
Ethnomedicine for neonatal jaundice: A cross-sectional survey in Qom, Iran. ( 27721052 )
2016
47
The study on clinical value of the detection about serum and Unconjugated Bilirubin in diagnosis of neonatal jaundice. ( 27005510 )
2016
48
Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study. ( 25950455 )
2015
49
Hyperactivity in the Gunn rat model of neonatal jaundice: age-related attenuation and emergence of gait deficits. ( 25518009 )
2015
50
Trans-Cutaneous Bilirubinometery versus Serum Bilirubin in Neonatal Jaundice. ( 26749233 )
2015

Variations for Neonatal Jaundice

Expression for Neonatal Jaundice

Search GEO for disease gene expression data for Neonatal Jaundice.

Pathways for Neonatal Jaundice

Pathways related to Neonatal Jaundice according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.96 HMOX1 HMOX2 UGT1A1
2
Show member pathways
11.26 NR1I3 UGT1A1
3
Show member pathways
11.24 SLCO1B1 UGT1A1
4 11.18 HMOX1 HMOX2
5 11.09 G6PD GSTM1 HMOX1 UGT1A1
6
Show member pathways
11.04 SLCO1B1 UGT1A1
7 10.95 HMOX1 IL6
8
Show member pathways
10.9 GSTM1 UGT1A1
9 10.85 HMOX1 IL6
10 10.76 NR1I3 UGT1A1
11 10.43 HMOX1 IL6
12 10.19 NR1I3 SLCO1B1

GO Terms for Neonatal Jaundice

Cellular components related to Neonatal Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic side of plasma membrane GO:0009898 8.62 G6PD SPTA1

Biological processes related to Neonatal Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 glutathione metabolic process GO:0006749 9.4 G6PD GSTM1
2 iron ion homeostasis GO:0055072 9.37 HMOX1 HMOX2
3 response to hypoxia GO:0001666 9.33 HMOX1 HMOX2 PKLR
4 acute-phase response GO:0006953 9.32 IL6 UGT1A1
5 regulation of angiogenesis GO:0045765 9.26 HMOX1 IL6
6 heme oxidation GO:0006788 8.96 HMOX1 HMOX2
7 heme catabolic process GO:0042167 8.8 HMOX1 HMOX2 UGT1A1

Molecular functions related to Neonatal Jaundice according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme oxygenase (decyclizing) activity GO:0004392 8.62 HMOX1 HMOX2

Sources for Neonatal Jaundice

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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