MCID: NNT012
MIFTS: 46

Neonatal Jaundice malady

Summaries for Neonatal Jaundice

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63Wikipedia, 32MalaCards
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Wikipedia:63 Neonatal jaundice or Neonatal hyperbilirubinemia, or Neonatal icterus (from the Greek word... more...

MalaCards: Neonatal Jaundice, also known as jaundice neonatal, is related to kernicterus and hepatitis. An important gene associated with Neonatal Jaundice is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Heme Biosynthesis and heme degradation. The compounds n-acetylbenzidine and sn38 glucuronide have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and brain.

Aliases & Classifications for Neonatal Jaundice

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8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

neonatal jaundice 8 10 60
jaundice neonatal 44


External Ids:

Disease Ontology8 DOID:2383
MeSH34 D007567

Related Diseases for Neonatal Jaundice

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17GeneCards, 18GeneDecks
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Diseases related to Neonatal Jaundice via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1kernicterus30.8G6PD, UGT1A9, SLC35A2, RHD, UGT1A7, UGT1A10
2hepatitis30.2UGT1A1
3gilbert syndrome30.2UGT1A7, UGT1A1, UGT1A4, G6PD
4crigler-najjar syndrome29.9UGT1A4, UGT1A1
5hereditary spherocytosis29.9G6PD, UGT1A1, RHD
6beta thalassemia29.9RHD, UGT1A1, G6PD
7glucosephosphate dehydrogenase deficiency29.9G6PD, PKLR
8breast/ovarian cancer, hereditary: brca1/brca2/additional genes sequence analysis multi-gene panels10.6
9biliary atresia10.3
10meconium aspiration syndrome10.3
11hyperbilirubinemia, familial transcient neonatal10.3
12burns10.1
13liver cirrhosis10.0BTD
14cholelithiasis10.0UGT1A1, UGT1A6
15crigler najjar syndrome, type 210.0UGT1A4, UGT1A1
16congenital nonspherocytic hemolytic anemia10.0PKLR, G6PD
17cholestasis10.0HSD3B7, CIRH1A
18neutropenia10.0UGT1A1, UGT1A6
19congenital hemolytic anemia10.0PKLR, G6PD
20bilirubin metabolic disorder10.0G6PD, UGT1A1, UGT1A7
21deficiency anemia10.0G6PD, RHD, PKLR
22hereditary elliptocytosis10.0G6PD, RHD
23diarrhea10.0UGT1A6, UGT1A1
24alpha thalassemia10.0UGT1A1, G6PD
25sickle cell disease10.0BTD, RHD, UGT1A1, G6PD
26hemolytic anemia10.0PKLR, RHD, UGT1A1, G6PD
27phenylketonuria10.0BTD, G6PD
28pyruvate kinase deficiency10.0G6PD, PKLR
29galactosemia10.0HSD3B7, G6PD, UGT1A1, BTD
30cystic fibrosis10.0
31obstructive jaundice10.0
32sensorineural hearing loss10.0
33allergic rhinitis10.0
34cerebritis10.0
35sialuria10.0
36hyperargininemia10.0
37dubin-johnson syndrome10.0
38asthma10.0
39autism spectrum disorder10.0
40blood group incompatibility10.0
41cataract10.0
42intestinal obstruction10.0
43rhinitis10.0
44thalassemia10.0
45toxoplasmosis10.0
46hemoglobinopathy10.0G6PD, BTD
47colorectal cancer10.0OSM, UGT1A9, UGT1A6, UGT1A1, UGT1A7
48colon cancer10.0UGT1A10, UGT1A1, OSM

Graphical network of the top 20 diseases related to Neonatal Jaundice:



Diseases related to neonatal jaundice

Clinical Features for Neonatal Jaundice

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Drugs & Therapeutics for Neonatal Jaundice

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neonatal Jaundice

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Anatomical Context for Neonatal Jaundice

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32MalaCards
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MalaCards organs/tissues related to Neonatal Jaundice:

32
Skin, Breast, Brain, Eye, Colon

Animal Models for Neonatal Jaundice or affiliated genes

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Publications for Neonatal Jaundice

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50PubMed
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Articles related to Neonatal Jaundice:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Management of neonatal jaundice varies by practitioner type. (23946045)
2013
2
The side effects of phototherapy for neonatal jaundice: what do we know? What should we do? (21455834)
2011
3
'Halving the heel pricks': evaluation of a neonatal jaundice protocol incorporating the use of a transcutaneous bilirubinometer. (20722994)
2010
4
Neonatal jaundice, autism, and other disorders of psychological development. (20937652)
2010
5
Decreased neonatal jaundice readmission rate after implementing hyperbilirubinemia guidelines and universal screening for bilirubin. (20693521)
2010
6
Obstructive jaundice in neonates. (20426278)
2009
7
Role of bilirubin as antioxidant in neonatal jaundice and effect of ethanolic extract of sweet lime peel on experimentally induced jaundice in rat. (19374257)
2009
8
Can haptoglobin be an indicator for the early diagnosis of neonatal jaundice? (19021267)
2008
9
Neonatal jaundice: a risk factor for infantile autism? (19000294)
2008
10
A practical approach to neonatal jaundice. (18540490)
2008
11
Phototherapy for neonatal jaundice. (18536103)
2008
12
Readmission for neonatal jaundice in California, 1991-2000: trends and implications. (18381515)
2008
13
Neonatal cholestatic jaundice as the first symptom of a mutation in the hepatocyte nuclear factor-1beta gene (HNF-1beta). (17307554)
2007
14
BiliCheck transcutaneous bilirubinometer: a screening tool for neonatal jaundice in the Chinese population. (16603775)
2006
15
Neonatal jaundice and bilirubin UDP-glucuronosyl transferase 1A1 gene polymorphism in Turkish patients. (16623861)
2006
16
Breast-feeding, neonatal jaundice and kernicterus. (12208098)
2002
17
Early recognition of neonatal jaundice and kernicterus. (12881930)
2002
18
Neonatal jaundice, animal-induced injuries, and immunizations. (11717566)
2001
19
Fibreoptic phototherapy for neonatal jaundice. (11279748)
2001
20
Intestinal colonization leading to fecal urobilinoid excretion may play a role in the pathogenesis of neonatal jaundice. (10749414)
2000
21
Investigation of prolonged neonatal jaundice. (10914965)
2000
22
Neonatal jaundice, animal-induced injuries, and immunizations. (10943826)
2000
23
Neonatal jaundice. Strategies to reduce bilirubin-induced complications. (10576009)
1999
24
The preliminary study on prevention and treatment of neonatal jaundice]. (9596945)
1997
25
Neonatal jaundice, animal-induced injuries and disease, and immunizations. (9300206)
1997
26
Neonatal jaundice: An etiological survey in the Madinah Region. (17372480)
1996
27
G6PD NanKang (517 T-->C; 173 Phe-->Leu): a new Chinese G6PD variant associated with neonatal jaundice. (8807322)
1996
28
Effect of phototherapy for neonatal jaundice on cognitive performance. (8169674)
1994
29
Animal-induced injuries and disease, neonatal jaundice, viral infections, and immunizations. (8374681)
1993
30
Neonatal jaundice in Asia. (1596589)
1992
31
Somatosensory evoked potentials in neonatal jaundice. (2321476)
1990
32
Assessment of neonatal jaundice in low birth weight infants comparing transcutaneous, capillary and arterial bilirubin levels. (2079079)
1990
33
Relationship between exposure to icterogenic agents, glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice in Nigeria. (2603709)
1989
34
Neonatal jaundice. (3281408)
1988
35
Unexplained neonatal jaundice as an early diagnostic sign of septicemia in the newborn. (3236101)
1988
36
Neonatal jaundice: current concepts. (3822013)
1987
37
Phototherapy for neonatal jaundice: clinical equivalence of fluorescent green and "special" blue lamps. (3950827)
1986
38
Neonatal jaundice and coagulopathy. (4067760)
1985
39
Intrapartum infusion of oxytocin and glucose water and neonatal jaundice. (6485318)
1984
40
Phototherapy for neonatal jaundice in infants with intestinal obstruction. (6886916)
1983
41
What causes neonatal jaundice in Harare? (6616585)
1983
42
Early onset of homozygous beta o thalassaemia associated with neonatal jaundice. (570377)
1979
43
Neonatal jaundice in eastern Nigeria. (520244)
1979
44
Some aspects on management of neonatal jaundice in Singapore. (750753)
1978
45
Early onset of homozygous betao-thalassaemia associated with neonatal jaundice. (646434)
1978
46
Red cell metabolism and severe neonatal jaundice in West Malaysia. (409030)
1977
47
Phototherapy for neonatal jaundice. (885072)
1977
48
Phototherapy--current status in the treatment of neonatal jaundice. (977099)
1976
49
Oxytocin and neonatal jaundice. (990767)
1976
50
PATTERN OF SERUM TRANSAMINASE ACTIVITY IN NEONATAL JAUNDICE DUE TO CYTOMEGALIC INCLUSION DISEASE AND TOXOPLASMOSIS WITH HEPATIC INVOLVEMENT. (14074424)
1963

Genetic Variations for Neonatal Jaundice

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Expression for genes affiliated with Neonatal Jaundice

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neonatal Jaundice

Search GEO for disease gene expression data for Neonatal Jaundice.

Pathways for genes affiliated with Neonatal Jaundice

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37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 12EMD Millipore, 29KEGG
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Pathways related to Neonatal Jaundice according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.2UGT1A1, HMOX2
2
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10.2HMOX2, UGT1A1
3
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10.2UGT1A10, UGT1A4
4
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10.2UGT1A1, UGT1A9
5
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10.2UGT1A1, UGT1A8
6
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10.2UGT1A9, UGT1A4
710.2UGT1A9, UGT1A4
8
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10.2G6PD, BPNT1
9
Saturated fatty acid biosynthesis
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10.2BTD, PKLR
1010.0UGT1A3, UGT1A10, UGT1A8
11
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10.0UGT1A9, UGT1A10, UGT1A6
12
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9.9UGT1A1, UGT1A3, UGT1A10, UGT1A9
13
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9.9UGT1A9, UGT1A1, UGT1A6, UGT1A4
14
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9.6UGT1A3, UGT1A10, UGT1A1, UGT1A8, UGT1A4, UGT1A9
15
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9.5UGT1A1, UGT1A3, UGT1A4, UGT1A8, UGT1A6, UGT1A9
169.5UGT1A9, UGT1A3, UGT1A10, UGT1A6, UGT1A8, UGT1A4
17
Acetaminophen metabolism
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9.4UGT1A8, UGT1A9, UGT1A4, UGT1A3, UGT1A10, UGT1A6
18
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9.2UGT1A4, UGT1A8, UGT1A6, UGT1A7, UGT1A1, UGT1A10
19
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9.1UGT1A3, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1
20
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9.1UGT1A9, UGT1A8, UGT1A6, UGT1A1, UGT1A5, UGT1A10
21
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8.9UGT1A3, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1
22
Hide members
8.4BPNT1, UGT1A9, UGT1A8, UGT1A6, UGT1A1, UGT1A5

Compounds for genes affiliated with Neonatal Jaundice

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Neonatal Jaundice according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1n-acetylbenzidine4410.4UGT1A4, UGT1A9, UGT1A1
2sn38 glucuronide4410.3UGT1A7, UGT1A1, UGT1A9
3acetaminophen glucuronide44 2411.3UGT1A1, UGT1A6, UGT1A9
4Ezogabine 1110.3UGT1A1, UGT1A9, UGT1A4, UGT1A3
5lamotrigine44 1111.3UGT1A1, UGT1A4, UGT1A6, UGT1A3
64-methylumbelliferone4410.2UGT1A6, UGT1A1, UGT1A9
71-naphthol4410.2UGT1A6, UGT1A9, UGT1A1
8udp glucuronic acid4410.2UGT1A8, UGT1A6, UGT1A10, UGT1A1
9benzidine4410.2UGT1A6, UGT1A1, UGT1A9, UGT1A4
10n-hydroxy-n-acetylbenzidine4410.2UGT1A9, UGT1A4
11phenol44 2411.2G6PD, UGT1A1, UGT1A6, UGT1A9
12trifluoperazine44 28 1112.2UGT1A4, UGT1A9, UGT1A6, UGT1A1
13etodolac44 1111.1UGT1A9, UGT1A10, UGT1A3
14p-nitrophenol44 1111.1UGT1A9, UGT1A3, UGT1A4, UGT1A1, UGT1A6
15mycophenolic acid44 49 1112.1UGT1A9, UGT1A8, UGT1A1, UGT1A10, UGT1A7
16diclofenac44 28 49 1113.1UGT1A3, UGT1A1, UGT1A6, UGT1A4, UGT1A9
17mycophenolate mofetil44 49 1112.1UGT1A8, UGT1A10, UGT1A1, UGT1A9
18phip4410.0UGT1A9, UGT1A1, UGT1A4
19benzo(a)pyrene4410.0UGT1A1, UGT1A6, UGT1A7, UGT1A9
20uridine44 11 2412.0UGT1A6, UGT1A4, UGT1A9, UGT1A1, UGT1A7
21irinotecan44 49 1112.0UGT1A9, UGT1A7, UGT1A1, UGT1A6
22amine4410.0UGT1A3, UGT1A1, UGT1A7, UGT1A4
23flurbiprofen44 28 49 1112.9UGT1A1, UGT1A3, UGT1A9
24morphine44 49 28 1112.9UGT1A1, UGT1A9, UGT1A8, UGT1A6, UGT1A4, UGT1A3
25tamoxifen44 49 28 1112.9UGT1A1, G6PD, UGT1A9, UGT1A4, UGT1A6, UGT1A3
26glucuronide449.9UGT1A3, UGT1A7, UGT1A9, UGT1A4, UGT1A6, UGT1A1
27acetaminophen44 2 49 11 2413.9G6PD, UGT1A1, UGT1A4, UGT1A9, UGT1A6, UGT1A10
28uridine diphosphate449.8UGT1A9, UGT1A7, UGT1A3, UGT1A10, UGT1A1, UGT1A6
29n-hydroxy phip449.8UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
30propofol44 49 1111.8UGT1A4, UGT1A9, UGT1A6, UGT1A1, UGT1A10, UGT1A8
31troglitazone44 28 59 1112.8UGT1A4, UGT1A1, UGT1A3, UGT1A10, UGT1A6, UGT1A8
32buprenorphine44 28 1111.7UGT1A9, UGT1A1, UGT1A3
33ethyl glucuronide44 2410.7UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10, UGT1A7
34cotinine44 2410.7UGT1A9, UGT1A8, UGT1A1, UGT1A6, UGT1A10, UGT1A7
35imipramine44 49 28 11 2413.7UGT1A4, UGT1A6, UGT1A7, UGT1A9, UGT1A1, UGT1A8
36nicotine44 49 28 1112.6UGT1A4, UGT1A8, UGT1A9, UGT1A1, UGT1A10, UGT1A7
37androsterone glucuronide44 2410.6UGT1A5, UGT1A10, UGT1A7, UGT1A3, UGT1A1, UGT1A6
383-alpha-androstanediol glucuronide44 2410.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
39etiocholanolone44 2410.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
40estriol28 11 2411.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
41estrone44 28 11 2412.6UGT1A7, UGT1A3, UGT1A10, UGT1A5, UGT1A1, UGT1A9
422-methoxyestradiol44 59 2411.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
43(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)249.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
44bilirubin diglucuronide44 2410.6UGT1A10, UGT1A7, UGT1A3, UGT1A5, UGT1A1, UGT1A6
45aldosterone 18-glucuronide44 2410.5UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
46codeine44 49 28 11 2413.5UGT1A3, UGT1A7, UGT1A9, UGT1A4, UGT1A8, UGT1A6
47valproic acid44 49 11 2412.5UGT1A3, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
48testosterone44 59 11 2412.4UGT1A7, UGT1A9, UGT1A10, UGT1A3, G6PD, UGT1A4
49estradiol44 11 2411.3UGT1A6, UGT1A9, UGT1A8, UGT1A4, UGT1A7, UGT1A1
50retinoic acid44 2410.3UGT1A9, UGT1A8, UGT1A3, UGT1A4, UGT1A6, UGT1A1

GO Terms for genes affiliated with Neonatal Jaundice

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16Gene Ontology
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Cellular components related to Neonatal Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular membrane-bounded organelleGO:0432319.4UGT1A9, UGT1A8, UGT1A6, UGT1A5, G6PD
2integral to membraneGO:0160218.8UGT1A10, SLC35A2, TAAR8, UGT1A7, HSD3B7, UGT1A9
3endoplasmic reticulum membraneGO:0057898.8HMOX2, HSD3B7, UGT1A9, UGT1A4, UGT1A8, UGT1A6

Biological processes related to Neonatal Jaundice according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1porphyrin-containing compound metabolic processGO:00677810.2HMOX2, UGT1A1
2negative regulation of steroid metabolic processGO:04593910.2UGT1A1, UGT1A8
3cellular glucuronidationGO:05269510.1UGT1A4, UGT1A10, UGT1A1, UGT1A6
4negative regulation of fatty acid metabolic processGO:04592210.1UGT1A9, UGT1A8, UGT1A7
5coumarin metabolic processGO:00980410.0UGT1A8, UGT1A7
6negative regulation of catalytic activityGO:04308610.0UGT1A9, UGT1A7, UGT1A1, UGT1A8
7flavone metabolic processGO:05155210.0UGT1A7, UGT1A10, UGT1A1, UGT1A8, UGT1A9
8flavonoid glucuronidationGO:05269610.0UGT1A8, UGT1A9, UGT1A1, UGT1A7, UGT1A3
9xenobiotic glucuronidationGO:05269710.0UGT1A3, UGT1A7, UGT1A1, UGT1A8, UGT1A9
10retinoic acid metabolic processGO:04257310.0UGT1A8, UGT1A3, UGT1A7, UGT1A9, UGT1A1
11drug metabolic processGO:01714410.0UGT1A7, UGT1A8, UGT1A9, UGT1A1
12metabolic processGO:0081529.9UGT1A5, UGT1A9, UGT1A6, UGT1A3, UGT1A10
13heme catabolic processGO:0421679.9HMOX2, UGT1A1
14xenobiotic metabolic processGO:0068059.7BPNT1, UGT1A9, UGT1A4, UGT1A5, UGT1A1, UGT1A6
15small molecule metabolic processGO:0442819.1PKLR, HMOX2, BTD, UGT1A1, UGT1A6, UGT1A4

Molecular functions related to Neonatal Jaundice according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00549610.2UGT1A8, UGT1A1
2enzyme inhibitor activityGO:0048579.5UGT1A9, UGT1A8, UGT1A1, UGT1A7
3retinoic acid bindingGO:0019729.4UGT1A3, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1
4enzyme bindingGO:0198999.3UGT1A10, UGT1A1, UGT1A6, UGT1A8, UGT1A4, UGT1A9
5glucuronosyltransferase activityGO:0150209.2UGT1A7, UGT1A3, UGT1A5, UGT1A1, UGT1A6, UGT1A8
6protein heterodimerization activityGO:0469829.2UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10, UGT1A7
7protein homodimerization activityGO:0428039.1G6PD, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1

Products for genes affiliated with Neonatal Jaundice

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  • Antibodies
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Sources for Neonatal Jaundice

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet