MCID: NNT012
MIFTS: 46

Neonatal Jaundice malady

Fetal diseases category

Summaries for Neonatal Jaundice

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Disease Ontology:10 A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant.

MalaCards based summary: Neonatal Jaundice, also known as neonatal hyperbilirubinemia, is related to glucose-6-phosphate dehydrogenase deficiency and kernicterus. An important gene associated with Neonatal Jaundice is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Glucose / Energy Metabolism and Metabolism of porphyrins. The compounds zinc protoporphyrin and phenol have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and brain.

Wikipedia:65 Neonatal jaundice or Neonatal hyperbilirubinemia, or Neonatal icterus (from the Greek word ???????),... more...

Aliases & Classifications for Neonatal Jaundice

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Sources:
10Disease Ontology, 12DISEASES, 62UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH, 27ICD10
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Related Diseases for Neonatal Jaundice

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Diseases related to Neonatal Jaundice via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1glucose-6-phosphate dehydrogenase deficiency31.0G6PD, UGT1A1
2kernicterus30.9UGT1A1, G6PD
3gilbert syndrome30.3UGT1A1
4hereditary spherocytosis30.3UGT1A1, G6PD
5cholestasis30.1CIRH1A, HSD3B7
6thalassemia30.0G6PD, UGT1A1
7biliary atresia10.3
8meconium aspiration syndrome10.3
9hyperbilirubinemia, familial transient neonatal10.3
10niemann-pick disease, type a10.2
11pyruvate kinase deficiency10.2
12hemolytic anemia due to g6pd deficiency10.2
13burns10.2
14hepatitis10.2
15athetosis10.2
16cytomegalic inclusion disease10.2
17lucey-driscoll syndrome10.2
18spastic paraplegia 29, autosomal dominant10.1
19cleidocranial dysplasia10.1
20hemolytic anemia due to glutathione peroxidase deficiency10.1
21leukemia10.1
22congenital hypothyroidism10.1
23childhood leukemia10.1
24hypothyroidism10.1
25brainstem auditory evoked responses10.1
26edinburgh malformation syndrome10.1
27mitochondrial dna depletion syndrome 610.0
28microcephalic osteodysplastic primordial dwarfism, type i10.0
29asthma10.0
30pituitary hormone deficiency, combined, 110.0
31attention deficit-hyperactivity disorder10.0
32bile acid synthesis defect, congenital, 410.0
33allergic rhinitis10.0
34peroxisome biogenesis disorder 1a10.0
35cystic fibrosis10.0
36sialuria10.0
37dubin-johnson syndrome10.0
38niemann-pick disease, type c210.0
39niemann-pick disease, type c110.0
40prolidase deficiency10.0
41alagille syndrome10.0
42aicardi-goutieres syndrome 1, dominant and recessive10.0
43thrombotic thrombocytopenic purpura, familial10.0
44dyserythropoietic anemia, congenital, type ia10.0
45cirrhosis, north american indian childhood type10.0
46galactokinase deficiency with cataracts10.0
47cataract10.0
48sensorineural hearing loss10.0
49cerebritis10.0
50autism spectrum disorder10.0

Graphical network of the top 20 diseases related to Neonatal Jaundice:



Diseases related to neonatal jaundice

Symptoms for Neonatal Jaundice

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Drugs & Therapeutics for Neonatal Jaundice

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Drug clinical trials:

Search ClinicalTrials for Neonatal Jaundice

Search NIH Clinical Center for Neonatal Jaundice

Genetic Tests for Neonatal Jaundice

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Anatomical Context for Neonatal Jaundice

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MalaCards organs/tissues related to Neonatal Jaundice:

33
Skin, Breast, Brain, Eye, Colon

Animal Models for Neonatal Jaundice or affiliated genes

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Publications for Neonatal Jaundice

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Articles related to Neonatal Jaundice:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
Care practices and traditional beliefs related to neonatal jaundice in northern Vietnam: a population-based, cross-sectional descriptive study. (25316215)
2014
2
Neonatal jaundice and increased risk of attention-deficit hyperactivity disorder: a population-based cohort study. (25056274)
2014
3
Fluorescence Excitation Spectrum of Bilirubin in Blood: A Model for the Action Spectrum for Phototherapy of Neonatal Jaundice. (23998276)
2013
4
Influence of Changes in the Evaluation of Neonatal Jaundice. (23616073)
2013
5
Evaluation of maternal knowledge level about neonatal jaundice. (22082141)
2012
6
Bilirubin rebound after intensive phototherapy for neonatal jaundice. (20019393)
2010
7
Twists and turns in phototherapy for neonatal jaundice. (20528792)
2010
8
Maternal experience with neonatal jaundice. (20032753)
2010
9
Neonatal adrenal hemorrhage presenting as late onset neonatal jaundice. (20419026)
2009
10
Knowledge, attitude and behaviour of mothers on neonatal jaundice. (19157319)
2008
11
Prolonged neonatal jaundice and the diagnosis of biliary atresia: a single-center analysis of trends in age at diagnosis and outcomes. (18443020)
2008
12
Are glutathione S-transferase gene polymorphisms linked to neonatal jaundice? (17318621)
2008
13
Letter to the Editors: the burden of neonatal jaundice and sepsis in developing countries. (16553919)
2006
14
Neonatal jaundice. (15652016)
2004
15
Breast-feeding, neonatal jaundice and kernicterus. (12208098)
2002
16
Pharmacological interventions for the treatment of neonatal jaundice. (12208095)
2002
17
Spectrum of outcome in infants with extreme neonatal jaundice. (11519982)
2001
18
Managing the assessment of neonatal jaundice: importance of timing. (11105424)
2000
19
Neonatal jaundice, animal-based injuries, and immunizations. (9757374)
1998
20
Comparison technetium of Tc-99m disofenin cholescintigraphy with ultrasonography in the differentiation of biliary atresia from other forms of neonatal jaundice. (9035206)
1997
21
Neonatal jaundice due to ABO incompatibility in Sri Lankan. (10830015)
1996
22
Can severe neonatal jaundice be prevented by neonatal screening for glucose-6-phosphate dehydrogenase deficiency?--a review of evidence. (8942026)
1996
23
Neonatal jaundice, aflatoxins and naphthols: report of a study in Ibadan, Nigeria. (7677410)
1995
24
Neonatal jaundice. (7824404)
1994
25
Etiology of neonatal jaundice at Shimla. (7875794)
1994
26
Animal-induced injuries and disease, neonatal jaundice, viral infections, and immunizations. (8374681)
1993
27
Neonatal jaundice: update on phototherapy management. (8363337)
1993
28
Treating neonatal jaundice with phenobarbitone: the inadvertant administration of significant doses of ethyl alcohol. (1739339)
1992
29
Value of bile acid determination for the diagnosis of neonatal jaundice. (2102973)
1990
30
Management of neonatal jaundice. (2683113)
1989
31
Neonatal jaundice. (3281408)
1988
32
Neonatal jaundice in the home: assessment with a noninvasive device. (3681515)
1987
33
Sunburn from the treatment of neonatal jaundice. (3719406)
1986
34
Free and erythrocyte-bound bilirubin in neonatal jaundice. (3751548)
1986
35
123I BSP scanning in neonatal jaundice. (3566138)
1986
36
Neonatal jaundice among full term infants in Riyadh: a prospective study of 190 hospital admissions. (4092624)
1985
37
Bupivacaine alters red blood cell properties: a possible explanation for neonatal jaundice associated with maternal anesthesia. (4000759)
1985
38
Blood brain barrier in neonatal jaundice. (3843560)
1985
39
Chemoprevention of neonatal jaundice: potency of tin-protoporphyrin in an animal model. (6896768)
1982
40
The use of diethyl-IDA Tc 99m clearance curves in the differentiation of biliary atresia from other forms of neonatal jaundice. (7063701)
1982
41
Hepatobiliary scintigraphy with 99mTc-PIPIDA in the evaluation of neonatal jaundice. (6787555)
1981
42
Simultaneous 99mTc-P-butyl-IDA and 131I-rose bengal scintigraphy in neonatal jaundice. (7355225)
1980
43
Early onset of homozygous beta o thalassaemia associated with neonatal jaundice. (570377)
1979
44
Factors influencing the incidence of neonatal jaundice. (647211)
1978
45
Phototherapy for neonatal jaundice in erythrocyte glucose-6-phosphate dehydrogenase-deficient infants. (559284)
1977
46
Red cell metabolism and severe neonatal jaundice in West Malaysia. (409030)
1977
47
Red cell potassium levels in neonatal jaundice --a preliminary study. (859375)
1977
48
Phototherapy for neonatal jaundice in rural Africa. (841688)
1977
49
Oxytocin and neonatal jaundice. (974702)
1976
50
Cytomegalic inclusion disease: another cause for neonatal jaundice. (13611436)
1959

Variations for Neonatal Jaundice

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Expression for genes affiliated with Neonatal Jaundice

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Search GEO for disease gene expression data for Neonatal Jaundice.

Pathways for genes affiliated with Neonatal Jaundice

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Pathways related to Neonatal Jaundice according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5HMOX2, G6PD
2
Show member pathways
tetrapyrrole biosynthesis38
heme degradation38
Heme Biosynthesis38
heme biosynthesis38
heme biosynthesis from uroporphyrinogen-III I38
9.3HMOX2, UGT1A1
3
Show member pathways
8.1HMOX2, G6PD, HSD3B7, UGT1A1

Compounds for genes affiliated with Neonatal Jaundice

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Sources:
45Novoseek, 26HMDB, 3BitterDB, 51PharmGKB, 13DrugBank, 30IUPHAR
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Compounds related to Neonatal Jaundice according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1zinc protoporphyrin459.7HMOX2, G6PD
2phenol45 2610.6UGT1A1, G6PD
3acetaminophen45 3 51 26 1313.6G6PD, UGT1A1
4phenobarbital45 30 51 1312.5G6PD, UGT1A1
5glucose 6-phosphate45 2610.5UGT1A1, G6PD
6egcg459.5G6PD, UGT1A1
7chloramphenicol45 3 51 1312.4G6PD, UGT1A1
8thyroxine45 2610.3UGT1A1, G6PD
9carbon459.2HMOX2, G6PD
10nadh45 26 1310.9HMOX2, G6PD, HSD3B7
11estrogen458.9HMOX2, G6PD, UGT1A1

GO Terms for genes affiliated with Neonatal Jaundice

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Cellular components related to Neonatal Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endoplasmic reticulum membraneGO:00057898.5HMOX2, HSD3B7, UGT1A1

Biological processes related to Neonatal Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme catabolic processGO:00421679.2HMOX2, UGT1A1
2porphyrin-containing compound metabolic processGO:00067789.0HMOX2, UGT1A1
3small molecule metabolic processGO:00442818.1HMOX2, G6PD, HSD3B7, UGT1A1

Products for genes affiliated with Neonatal Jaundice

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Sources for Neonatal Jaundice

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet