MCID: NNT012
MIFTS: 50

Neonatal Jaundice malady

Categories: Fetal diseases, Skin diseases

Aliases & Classifications for Neonatal Jaundice

Summaries for Neonatal Jaundice

Disease Ontology : 12 A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant.

MalaCards based summary : Neonatal Jaundice, also known as hyperbilirubinemia, neonatal, is related to kernicterus and pyruvate kinase deficiency, and has symptoms including icterus and newborn physiological jaundice. An important gene associated with Neonatal Jaundice is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways are Glucose / Energy Metabolism and Fluid shear stress and atherosclerosis. The drugs Insulin Lispro and Metformin have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and breast.

Wikipedia : 71 Neonatal jaundice or neonatal hyperbilirubinemia, or neonatal icterus (from the Greek word... more...

Related Diseases for Neonatal Jaundice

Diseases related to Neonatal Jaundice via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Related Disease Score Top Affiliating Genes
1 kernicterus 11.1
2 pyruvate kinase deficiency 11.1
3 bile acid synthesis defect, congenital, 4 10.7
4 sialuria 10.7
5 bile acid synthesis defect, congenital, 1 10.7
6 cirrhosis, north american indian childhood type 10.7
7 hemolytic anemia due to g6pd deficiency 10.7
8 immunodeficiency 47 10.7
9 hyperbilirubinemia, familial transient neonatal 10.2
10 abacavir toxicity 10.2 SLCO1B1 UGT1A1
11 atherosclerosis 10.2 HMOX1 IL6
12 renal artery disease 10.2 G6PD UGT1A1
13 endometriosis of uterus 10.1 G6PD SLCO1B1 UGT1A1
14 pyeloureteritis cystica 10.1 G6PD SLCO1B1 UGT1A1
15 oculomotor nerve paralysis 10.1 IL1B IL6
16 common peroneal nerve lesion 10.1 IL1B IL6
17 childhood electroclinical syndrome 10.1 IL1B IL6
18 anal paget's disease 10.1 IL1B IL6
19 laryngotracheoesophageal cleft type 2 10.1 IL1B IL6
20 glucosephosphate dehydrogenase deficiency 10.0 IL1B IL6
21 nodular degeneration of cornea 10.0 G6PD PKLR
22 bipolar i disorder 10.0 IL1B IL6
23 histiocytoid hemangioma 10.0 HMOX1 IL1B IL6
24 human immunodeficiency virus infectious disease 10.0 IL1B IL6
25 dextrocardia 10.0 IL1B IL6
26 tinea capitis 9.9 IL1B IL6
27 ovarian mucinous adenocarcinoma 9.9 GSTM1 HMOX1 IL1B
28 baritosis 9.9 GSTM1 IL1B IL6
29 vagus nerve neoplasm 9.9 G6PD PKLR UGT1A1
30 larynx leiomyoma 9.9 IL1B IL6 OXT
31 migraine with aura 9.9 IL1B IL6 OXT
32 blepharochalasis 9.9 IL1B IL6 OXT
33 spinal multifocal clear cell meningioma 9.9 IL1B IL6 OXT
34 infancy electroclinical syndrome 9.9 IL1B IL6 OXT
35 spondylolysis 9.9 IL1B IL6 OXT
36 immune system disease 9.9 GSTM1 IL1B IL6
37 avoidant personality disorder 9.9 IL1B IL6 OXT
38 measles 9.9 IL1B IL6
39 biliary atresia 9.8
40 pyelitis 9.8 G6PD HMOX1 NR1I3 SLCO1B1 UGT1A1
41 hereditary spherocytosis 9.7
42 gilbert syndrome 9.7
43 burns 9.7
44 athetosis 9.7
45 cytomegalic inclusion disease 9.7
46 hepatitis 9.7
47 sensorineural hearing loss 9.5
48 attention deficit-hyperactivity disorder 9.5
49 allergic rhinitis 9.5
50 cystic fibrosis 9.5

Graphical network of the top 20 diseases related to Neonatal Jaundice:



Diseases related to Neonatal Jaundice

Symptoms & Phenotypes for Neonatal Jaundice

UMLS symptoms related to Neonatal Jaundice:


icterus, newborn physiological jaundice

Drugs & Therapeutics for Neonatal Jaundice

Drugs for Neonatal Jaundice (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Insulin Lispro Approved Phase 4 133107-64-9
2
Metformin Approved Phase 4,Phase 2,Phase 3 657-24-9 14219 4091
3
Zinc Approved Phase 4,Phase 3,Phase 1,Phase 2 7440-66-6 32051 23994
4
Pyrimethamine Approved, Vet_approved Phase 4 58-14-0 4993
5
Sulfadoxine Approved Phase 4 2447-57-6 17134
6
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
7
Glyburide Approved Phase 4,Phase 3 10238-21-8 3488
8
Levoleucovorin Approved Phase 4 68538-85-2
9
Spiramycin Approved Phase 4 24916-50-5
10
Sulfadiazine Approved, Vet_approved Phase 4 68-35-9 5215
11
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
12
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
13
Bilirubin Phase 4,Phase 3,Phase 1,Phase 2 635-65-4 5280352
14 insulin Phase 4,Phase 3
15 Insulin, Globin Zinc Phase 4,Phase 3
16 Vitamin B Complex Phase 4
17 Antioxidants Phase 4,Phase 3,Phase 1,Phase 2
18 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2
19 Micronutrients Phase 4,Phase 1,Phase 2
20 Trace Elements Phase 4,Phase 1,Phase 2
21 Vitamins Phase 4
22 Hypoglycemic Agents Phase 4,Phase 2,Phase 3
23 Insulin, Isophane Phase 4
24 Insulin, Short-Acting Phase 4
25 Isophane insulin, beef Phase 4
26 Isophane Insulin, Human Phase 4
27 Protamines Phase 4
28 Antibodies Phase 4,Phase 3,Early Phase 1
29 gamma-Globulins Phase 4,Phase 3,Early Phase 1
30 Immunoglobulins Phase 4,Phase 3,Early Phase 1
31 Immunoglobulins, Intravenous Phase 4,Phase 3,Early Phase 1
32 Pharmaceutical Solutions Phase 4,Phase 2
33 Rho(D) Immune Globulin Phase 4,Phase 3,Early Phase 1
34 Anti-Infective Agents Phase 4,Phase 2,Early Phase 1
35 Antimalarials Phase 4
36 Antiparasitic Agents Phase 4
37 Antiprotozoal Agents Phase 4
38 Fanasil, pyrimethamine drug combination Phase 4
39 Folic Acid Antagonists Phase 4
40 Renal Agents Phase 4
41 Anti-Bacterial Agents Phase 4,Phase 2,Early Phase 1
42 Oxytocics Phase 4
43 Liver Extracts Phase 4,Phase 1,Phase 2
44 Antidotes Phase 4
45 Bone Density Conservation Agents Phase 4
46 Calcium, Dietary Phase 4
47 Folate Nutraceutical Phase 4
48 Vitamin B9 Nutraceutical Phase 4
49 Omega 3 Fatty Acid Nutraceutical Phase 4,Phase 1,Phase 2
50
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782

Interventional clinical trials:

(show top 50) (show all 121)
id Name Status NCT ID Phase
1 Use of a New Phototherapy Device (BBloo®) for the Treatment of Hyperbilirubinemia in the Newborn Infant Unknown status NCT02156050 Phase 4
2 Reverse Phototherapy With Super Light-emitting Diode(Super-LED) for Hyperbilirubinemia in Term and Late Preterm Infants Unknown status NCT01340339 Phase 4
3 Metformin Versus Insulin in Gestational Diabetes Completed NCT01240785 Phase 4
4 Efficacy of High-dose Intravenous Immunoglobulin Therapy for Hyperbilirubinemia Due Rh Hemolytic Disease Completed NCT00288600 Phase 4
5 Intermittent Preventive Treatment of Malaria in HIV-Seropositive Pregnant Women in Zambia Completed NCT00270530 Phase 4
6 Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency Recruiting NCT02594904 Phase 4
7 Continued Versus Discontinued Oxytocin Stimulation of Labour Recruiting NCT02553226 Phase 4
8 Preventing Recurrent Gestational Diabetes With Metformin Recruiting NCT02394158 Phase 4
9 Use of Omega-3 Fat Emulsion (Omegaven) in Infants With Parenteral Nutrition Associated Liver Disease Recruiting NCT00862446 Phase 4
10 Pyrimethamine, Sulfadiazine, and Leucovorin in Treating Patients With Congenital Toxoplasmosis Recruiting NCT00004317 Phase 4
11 The Effect of Intravenous Oxytocin Infusion Using Different Diluents on Neonatal Bilirubin & Sodium Levels Active, not recruiting NCT02602301 Phase 4
12 Glyburide Compared to Insulin in the Management of White's Classification A2 Gestational Diabetes Withdrawn NCT00160485 Phase 4
13 Trial of Aggressive Versus Conservative Phototherapy in Infants <1,000 Grams Birth Weight Completed NCT00114543 Phase 3
14 Transcutaneous Bilirubinometry in Healthy Term and Near-Term Neonates Completed NCT00653874 Phase 3
15 Efficacy and Safety of Stannsoporfin in Neonates Completed NCT02685137 Phase 3
16 Improving Health Outcomes for New Mothers and Babies Completed NCT00360204 Phase 3
17 Metformin in Obese Non-diabetic Pregnant Women Completed NCT01273584 Phase 2, Phase 3
18 Antenatal Late Preterm Steroids (ALPS): A Randomized Placebo-Controlled Trial Completed NCT01222247 Phase 3
19 a Randomized Multicenter Trial Comparing Vacuum Assisted Delivery With the New Device "iCUP" Versus the Reference Cup. Completed NCT01058200 Phase 3
20 Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD) Recruiting NCT02932475 Phase 3
21 Prospective Randomized Clinical Trial of Intravenous Lipids and Cholestasis Recruiting NCT01555957 Phase 3
22 Metformin in Women With Type 2 Diabetes in Pregnancy Trial Recruiting NCT01353391 Phase 3
23 Modulation of the Intestinal Flora With the Probiotic VIVOMIXX™ in Pregnant Women at Risk of Metabolic Complications Recruiting NCT02768818 Phase 3
24 A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV) Recruiting NCT01376778 Phase 3
25 Efficacy of Stem Cell Transplantation Compared to Rehabilitation Treatment of Patients With Cerebral Paralysis Recruiting NCT01929434 Phase 3
26 Multicenter Randomized Trial of Non-inferiority Between Glyburide and Insulin for the Treatment of Gestational Diabetes Active, not recruiting NCT01731431 Phase 3
27 EPO-4-Rhesus: Role of Darbepoetin Alfa in Reducing Late Anaemia in Neonates With Red Blood Cell Alloimmunization After Intrauterine Transfusions Not yet recruiting NCT03104426 Phase 2, Phase 3
28 Filtered Sunlight Phototherapy to Treat Significant Jaundice: Safety and Efficacy in Neonates Completed NCT02612727 Phase 1, Phase 2
29 Study Evaluating the Safety and Efficacy of Two Doses of Stannsoporfin in Combination With Phototherapy in Neonates With Hyperbilirubinemia Completed NCT01887327 Phase 2
30 Treatment of Neonatal Jaundice With Filtered Sunlight Phototherapy: Safety and Efficacy in African Neonates Completed NCT01434810 Phase 1, Phase 2
31 Follow-up, Blinded-Outcomes Trial of Subjects Having Received IMP in Clinical Trial 64,185-202 Completed NCT02033096 Phase 2
32 Phase II Randomized Study of Tin Mesoporphyrin for Neonatal Hyperbilirubinemia Completed NCT00004381 Phase 2
33 Efficacy of Zinc in Reducing Hyperbilirubinemia Among High Risk Neonates - A Double Blind Randomized Trial Completed NCT00692224 Phase 1, Phase 2
34 Phase II Study of Tin Mesoporphyrin vs Phototherapy for Hyperbilirubinemia in Premature Newborns Completed NCT00004382 Phase 2
35 Outcomes of Stem Cells for Cerebral Palsy Related to Neonatal Jaundice Completed NCT03123562 Phase 2
36 Safety and Pharmacology of Stanate Completed NCT00115544 Phase 2
37 Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants Completed NCT01081977 Phase 2
38 Ceftriaxone and Jaundice in Neonates Recruiting NCT03133637 Phase 2
39 A Safety and Efficacy Trial of Stannsoporfin in Neonates With Hyperbilirubinemia Terminated NCT00850993 Phase 2
40 SMOFlipid to Lessen the Severity of Neonatal Cholestasis Terminated NCT02721277 Phase 1, Phase 2
41 Study on Newborn Babies With a Yellow Skin Color (Neonatal Jaundice Study) Unknown status NCT02361788
42 Effect of Early Limited Formula on Total Serum Bilirubin Among Newborns With Hyperbilirubinemia Unknown status NCT01330667
43 Establishing Novel Detection Techniques for Various Genetic-Related Diseases by Applying DHPLC Platform. Unknown status NCT00154960
44 Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis Unknown status NCT00917007
45 Resting State Functional Magnetic Resonance Imaging Study of Jaundice Infants Before and After Light Treatment. Unknown status NCT02224586
46 New Phototherapy Device to Treat Patients With Crigler-Najjar Disease Unknown status NCT02356978
47 NPD Measurements in PSC Patients Unknown status NCT00476814
48 Inositol Stereoisomers to Treat Gestational Diabetes Unknown status NCT02097069
49 The Incidence and Risk Factors of Neonatal Hyperbilirubinemia in Term and Late-preterm Chinese Infants Completed NCT01762189
50 Prediction of Neonatal Hyperbilirubinemia Completed NCT01109277

Search NIH Clinical Center for Neonatal Jaundice

Cochrane evidence based reviews: jaundice, neonatal

Genetic Tests for Neonatal Jaundice

Anatomical Context for Neonatal Jaundice

MalaCards organs/tissues related to Neonatal Jaundice:

39
Skin, Eye, Breast, Liver, Brain, Colon

Publications for Neonatal Jaundice

Articles related to Neonatal Jaundice:

(show top 50) (show all 566)
id Title Authors Year
1
Yinzhihuang oral liquid in the treatment of neonatal jaundice: a meta-analysis. ( 27937684 )
2017
2
Clinical practices among healthcare professionals concerning neonatal jaundice and pale stools. ( 28083674 )
2017
3
Haemolytic and non-haemolytic neonatal jaundice have different risk factor profiles. ( 27173507 )
2016
4
Neonatal Jaundice with Splenomegaly: Not a Common Pick. ( 26847548 )
2016
5
Phototherapy for the Treatment of Neonatal Jaundice and Breastfeeding Duration and Exclusivity. ( 27057645 )
2016
6
Risk profiles for haemolytic and nonhaemolytic neonatal jaundice. ( 27870210 )
2016
7
Effects of baby massage on neonatal jaundice in healthy Iranian infants: A pilot study. ( 26646074 )
2016
8
Neonatal Jaundice in Low- and Middle-Income Countries: Lessons and Future Directions from the 2015 Don Ostrow Trieste Yellow Retreat. ( 27172942 )
2016
9
50 Years Ago in The Journal of Pediatrics: Studies of Prolonged Neonatal Jaundice in the Breast-Fed Infant. ( 26719182 )
2016
10
Kernicterus in Neonatal Jaundice-Finding the Needle in the Haystack. ( 26945202 )
2016
11
Cotoneaster and Neonatal Jaundice. ( 27891418 )
2016
12
The study on clinical value of the detection about serum and Unconjugated Bilirubin in diagnosis of neonatal jaundice. ( 27005510 )
2016
13
Ethnomedicine for neonatal jaundice: A cross-sectional survey in Qom, Iran. ( 27721052 )
2016
14
Effect of phototherapy on B and T lymphocytes in Egyptian infants suffering from neonatal jaundice. ( 27890454 )
2016
15
A Pilot Metabolic Profiling Study of Patients With Neonatal Jaundice and Response to Phototherapy. ( 27306191 )
2016
16
Gene Mutation in Neonatal Jaundice - Mutations in UGT1A1 and OATP2 Genes. ( 26960716 )
2016
17
Perceptions, practices, and traditional beliefs related to neonatal jaundice among Egyptian mothers: A cross-sectional descriptive study. ( 27603393 )
2016
18
Neonatal jaundice. ( 27387624 )
2016
19
The role of UGT1A1 promoter polymorphism and exon-1 mutations in neonatal jaundice. ( 27842454 )
2016
20
The burden and management of neonatal jaundice in Nigeria: A scoping review of the literature. ( 26755212 )
2016
21
Neonatal Jaundice Detection System. ( 27229489 )
2016
22
Cotoneaster: A Safe and Easy Way to Reduce Neonatal Jaundice. ( 27190910 )
2016
23
The effect of Cotoneaster manna on neonatal jaundice: A PRISMA-compliant systematic review. ( 27976153 )
2016
24
Prolonged neonatal jaundice and urinary tract infection. ( 27989001 )
2016
25
A Survey of Practice and Knowledge of Refugee and Migrant Pregnant Mothers Surrounding Neonatal Jaundice on the Thailand-Myanmar Border. ( 27576869 )
2016
26
Neonatal jaundice. ( 27353908 )
2016
27
Severe neonatal jaundice due to a de novo glucose-6-phosphate dehydrogenase deficient mutation. ( 26693676 )
2016
28
Screening for G6PD Deficiency Among Neonates with Neonatal Jaundice Admitted to Tertiary Care Center: A Need in Disguise. ( 26305316 )
2015
29
Screening neonatal jaundice based on the sclera color of the eye using digital photography. ( 26601015 )
2015
30
Neonatal jaundice and risks of childhood allergic diseases: a population-based cohort study. ( 25950455 )
2015
31
Hyperactivity in the Gunn rat model of neonatal jaundice: age-related attenuation and emergence of gait deficits. ( 25518009 )
2015
32
Therapeutic effects of probiotics on neonatal jaundice. ( 26649008 )
2015
33
Neonatal Jaundice: Knowledge, Attitude and practices of mothers in Mosan-Okunola community, Lagos, Nigeria. ( 26739202 )
2015
34
Early formation of bilirubin isomers during phototherapy for neonatal jaundice: effects of single vs. double fluorescent lamps vs. photodiodes. ( 25794186 )
2015
35
Antioxidant status in neonatal jaundice before and after phototherapy. ( 26015697 )
2015
36
Common questions about neonatal jaundice. ( 25730694 )
2015
37
Cord Blood Alkaline Phosphatase as an Indicator of Neonatal Jaundice. ( 26495102 )
2015
38
Transcutaneous bilirubinometry is a reliably conservative method of assessing neonatal jaundice. ( 26483074 )
2015
39
Supra-treatment threshold neonatal jaundice: Incidence in HIV-exposed compared to non-exposed neonates at Queen Elizabeth Central Hospital in Blantyre, Malawi. ( 26715956 )
2015
40
Therapeutic Effect of Agaricus brasiliensis on Phenylhydrazine-Induced Neonatal Jaundice in Rats. ( 25883968 )
2015
41
Trans-Cutaneous Bilirubinometery versus Serum Bilirubin in Neonatal Jaundice. ( 26749233 )
2015
42
Neonatal jaundice: phototherapy. ( 25998618 )
2015
43
The effect of massage on neonatal jaundice in stable preterm newborn infants: a randomized controlled trial. ( 26060154 )
2015
44
The role of intensive phototherapy in decreasing the need for exchange transfusion in neonatal jaundice. ( 24605703 )
2014
45
Liver disease in children: from neonatal jaundice to living donor liver transplantation. ( 26038791 )
2014
46
Visuocortical function in infants with a history of neonatal jaundice. ( 25183760 )
2014
47
Pattern and predictors of maternal care-seeking practices for severe neonatal jaundice in Nigeria: a multi-centre survey. ( 24774506 )
2014
48
What Do Mothers know about Neonatal Jaundice? Knowledge, Attitude and Practice of Mothers in Malaysia. ( 25934954 )
2014
49
Novel I+-Spectrin Mutation in Trans with I+-Spectrin Causing Severe Neonatal Jaundice from Hereditary Spherocytosis. ( 25277063 )
2014
50
Heme oxygenase-1 promoter polymorphisms and neonatal jaundice. ( 25277974 )
2014

Variations for Neonatal Jaundice

Expression for Neonatal Jaundice

Search GEO for disease gene expression data for Neonatal Jaundice.

Pathways for Neonatal Jaundice

GO Terms for Neonatal Jaundice

Biological processes related to Neonatal Jaundice according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.67 IL1B IL6 UGT1A1
2 response to hypoxia GO:0001666 9.63 HMOX1 HMOX2 PKLR
3 response to steroid hormone GO:0048545 9.54 OXT UGT1A1
4 acute-phase response GO:0006953 9.52 IL6 UGT1A1
5 regulation of angiogenesis GO:0045765 9.51 HMOX1 IL6
6 response to glucocorticoid GO:0051384 9.5 IL6 OXT UGT1A1
7 response to electrical stimulus GO:0051602 9.48 IL6 OXT
8 response to food GO:0032094 9.43 G6PD OXT
9 response to ATP GO:0033198 9.4 IL1B PKLR
10 positive regulation of chemokine biosynthetic process GO:0045080 9.37 HMOX1 IL1B
11 positive regulation of prostaglandin secretion GO:0032308 9.26 IL1B OXT
12 response to organic cyclic compound GO:0014070 9.26 G6PD IL6 OXT UGT1A1
13 heme oxidation GO:0006788 9.16 HMOX1 HMOX2
14 heme catabolic process GO:0042167 8.8 HMOX1 HMOX2 UGT1A1

Molecular functions related to Neonatal Jaundice according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heme oxygenase (decyclizing) activity GO:0004392 8.62 HMOX1 HMOX2

Sources for Neonatal Jaundice

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
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32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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37 KEGG
38 LifeMap
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42 MeSH
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54 OMIM
55 OMIM via Orphanet
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60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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