MCID: NNT012
MIFTS: 46

Neonatal Jaundice malady

Summaries for Neonatal Jaundice

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Neonatal jaundice or Neonatal hyperbilirubinemia, or Neonatal icterus (from the Greek word... more...

MalaCards: Neonatal Jaundice, also known as jaundice neonatal, is related to kernicterus and hepatitis. An important gene associated with Neonatal Jaundice is G6PD (glucose-6-phosphate dehydrogenase), and among its related pathways are Heme Biosynthesis and heme degradation. The compounds n-acetylbenzidine and sn38 glucuronide have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and brain.

Aliases & Classifications for Neonatal Jaundice

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

neonatal jaundice 8 10 60
jaundice neonatal 44


External Ids:

Disease Ontology8 DOID:2383
MeSH34 D007567

Related Diseases for Neonatal Jaundice

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Neonatal Jaundice via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1kernicterus30.8G6PD, UGT1A9, SLC35A2, RHD, UGT1A7, UGT1A10
2hepatitis30.2UGT1A1
3gilbert syndrome30.2UGT1A7, UGT1A1, UGT1A4, G6PD
4crigler-najjar syndrome29.9UGT1A4, UGT1A1
5hereditary spherocytosis29.9G6PD, UGT1A1, RHD
6beta thalassemia29.9RHD, UGT1A1, G6PD
7glucosephosphate dehydrogenase deficiency29.9G6PD, PKLR
8breast/ovarian cancer, hereditary: brca1/brca2/additional genes sequence analysis multi-gene panels10.6
9biliary atresia10.3
10meconium aspiration syndrome10.3
11hyperbilirubinemia, familial transcient neonatal10.3
12burns10.1
13liver cirrhosis10.0BTD
14cholelithiasis10.0UGT1A1, UGT1A6
15crigler najjar syndrome, type 210.0UGT1A4, UGT1A1
16congenital nonspherocytic hemolytic anemia10.0PKLR, G6PD
17cholestasis10.0HSD3B7, CIRH1A
18neutropenia10.0UGT1A1, UGT1A6
19congenital hemolytic anemia10.0PKLR, G6PD
20bilirubin metabolic disorder10.0G6PD, UGT1A1, UGT1A7
21deficiency anemia10.0G6PD, RHD, PKLR
22hereditary elliptocytosis10.0G6PD, RHD
23diarrhea10.0UGT1A6, UGT1A1
24alpha thalassemia10.0UGT1A1, G6PD
25sickle cell disease10.0BTD, RHD, UGT1A1, G6PD
26hemolytic anemia10.0PKLR, RHD, UGT1A1, G6PD
27phenylketonuria10.0BTD, G6PD
28pyruvate kinase deficiency10.0G6PD, PKLR
29galactosemia10.0HSD3B7, G6PD, UGT1A1, BTD
30cystic fibrosis10.0
31obstructive jaundice10.0
32sensorineural hearing loss10.0
33allergic rhinitis10.0
34cerebritis10.0
35sialuria10.0
36hyperargininemia10.0
37dubin-johnson syndrome10.0
38asthma10.0
39autism spectrum disorder10.0
40blood group incompatibility10.0
41cataract10.0
42intestinal obstruction10.0
43rhinitis10.0
44thalassemia10.0
45toxoplasmosis10.0
46hemoglobinopathy10.0G6PD, BTD
47colorectal cancer10.0OSM, UGT1A9, UGT1A6, UGT1A1, UGT1A7
48colon cancer10.0UGT1A10, UGT1A1, OSM

Graphical network of the top 20 diseases related to Neonatal Jaundice:



Diseases related to neonatal jaundice

Clinical Features for Neonatal Jaundice

About this section

Drugs & Therapeutics for Neonatal Jaundice

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Neonatal Jaundice

Drug clinical trials:

Search ClinicalTrials for Neonatal Jaundice

Search NIH Clinical Center for Neonatal Jaundice

Search CenterWatch for Neonatal Jaundice

Genetic Tests for Neonatal Jaundice

About this section

Anatomical Context for Neonatal Jaundice

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Neonatal Jaundice:

32
Skin, Breast, Brain, Eye, Colon

Animal Models for Neonatal Jaundice or affiliated genes

About this section

Publications for Neonatal Jaundice

About this section
Sources:
50PubMed
See all sources

Articles related to Neonatal Jaundice:

(show top 50)    (show all 541)
idTitleAuthorsYear
1
Neonatal jaundice is associated with a small increase in the risk of childhood type 1 diabetes: a meta-analysis of observational studies. (21984049)
2012
2
Is neonatal jaundice associated with Autism Spectrum Disorders: a systematic review. (22009628)
2011
3
Neonatal jaundice and human milk. (21942599)
2011
4
Neonatal jaundice: summary of NICE guidance. (20484363)
2010
5
Extreme neonatal jaundice: how frequent is it? (18540903)
2008
6
Phototherapy for neonatal jaundice. (18305267)
2008
7
Urinary tract infection in term neonates with prolonged jaundice. (17701928)
2007
8
Neonatal jaundice and splenic hematoma. (16465010)
2006
9
Incidence of hereditary spherocytosis in a population of jaundiced neonates. (16728359)
2006
10
Role of genetic factors in occurrence of neonatal jaundice in Guangxi region]. (16255851)
2005
11
An update on the prevalence of glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice in Tehran neonates. (14972648)
2004
12
Intestinal metabolism of bilirubin in the pathogenesis of neonatal jaundice. (14657836)
2003
13
System-based approach to management of neonatal jaundice and prevention of kernicterus. (12006952)
2002
14
Neonatal jaundice--traditional Chinese medicine approach. (11803427)
2001
15
Bilirubin production, breast-feeding and neonatal jaundice. (11519970)
2001
16
Onset of jaundice in glucose-6-phosphate dehydrogenase-deficient neonates. (11581450)
2001
17
Guidelines for treatment of neonatal jaundice. Is there a place for evidence-based medicine? (11332160)
2001
18
Neonatal jaundice and diet. (9988249)
1999
19
A variant TATA box in the bilirubin UDP-glucuronosyltransferase 1 gene promoter does not contribute to neonatal jaundice in the Japanese population. (10507878)
1999
20
Neonatal jaundice due to ABO incompatibility in Sri Lankan. (10830015)
1996
21
Criteria for treatment of neonatal jaundice. (8817445)
1996
22
Prediction and non-invasive assessment of neonatal jaundice in the term healthy newborn infant. (8740292)
1996
23
Infantile Refsum disease: neonatal cholestatic jaundice presentation of a peroxisomal disorder. (7533834)
1995
24
Enzyme deficiencies in neonates with jaundice. (8710395)
1995
25
Role of hemolysis in neonatal jaundice associated with glucose-6 phosphate dehydrogenase deficiency. (7472840)
1995
26
Association between glucose-6-phosphate dehydrogenase deficiency and neonatal jaundice: interaction with multiple risk factors. (1468858)
1992
27
Phototherapy for neonatal jaundice. (1934850)
1991
28
Value of bile acid determination for the diagnosis of neonatal jaundice. (2102973)
1990
29
Maternal smoking in relation to the incidence of early neonatal jaundice. (2920968)
1989
30
Neonatal jaundice. A 4 year experience in Toa Payoh Hospital. (3210669)
1988
31
Purple versus yellow: preventing neonatal jaundice with tin-porphyrins. (3050007)
1988
32
Neonatal jaundice in cystic fibrosis: a conservative approach is not always justified. (3388979)
1988
33
Neonatal jaundice in the home: assessment with a noninvasive device. (3681515)
1987
34
Tin-protoporphyrin and neonatal jaundice. (3149978)
1987
35
123I BSP scanning in neonatal jaundice. (3566138)
1986
36
Bupivacaine alters red blood cell properties: a possible explanation for neonatal jaundice associated with maternal anesthesia. (4000759)
1985
37
An immobilized enzyme reactor for treatment of severe neonatal jaundice. (3837454)
1985
38
An imaging approach to persistent neonatal jaundice. (6607624)
1984
39
A prospective study of the role of bacterial infection and G6PD deficiency in severe neonatal jaundice in Nigeria. (6474557)
1984
40
Clinicopathological Conference. Neonate with jaundice and leukopenia. (6955946)
1982
41
Combined treatment of neonatal jaundice with phototherapy, cholestyramine, and bicarbonate. (6788926)
1981
42
Neonatal jaundice. (7279043)
1981
43
Neonatal jaundice in ABO incompatible infants. Computer-assisted evaluation of risk of hyperbilirubinaemia and analysis of differences between sexes. (7016425)
1981
44
Hemolytic pattern of erythrocytes in the newborn measured by the coil planet centrifuge system and its relationship to neonatal jaundice. (627218)
1978
45
Phototherapy for neonatal jaundice in erythrocyte glucose-6-phosphate dehydrogenase-deficient infants. (559284)
1977
46
Red cell potassium levels in neonatal jaundice --a preliminary study. (859375)
1977
47
Adrenal hemorrhage in the newborn. The phenomenon of "enclosed" hemorrhage as a cause of neonatal jaundice and later adrenal calcifications. (844232)
1977
48
Phototherapy for neonatal jaundice in Chinese, Malay and Indian infants. (962730)
1976
49
Letter: Neonatal jaundice and erythrocyte-acid-phosphatase phenotype. (58192)
1976
50
Oxytocin and neonatal jaundice. (963435)
1976

Genetic Variations for Neonatal Jaundice

About this section

Expression for genes affiliated with Neonatal Jaundice

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Neonatal Jaundice

Search GEO for disease gene expression data for Neonatal Jaundice.

Pathways for genes affiliated with Neonatal Jaundice

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 12EMD Millipore, 29KEGG
See all sources

Pathways related to Neonatal Jaundice according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2HMOX2, UGT1A1
2
Hide members
10.2HMOX2, UGT1A1
3
Hide members
10.2UGT1A10, UGT1A4
4
Hide members
10.2UGT1A9, UGT1A1
5
Hide members
10.2UGT1A1, UGT1A8
610.2UGT1A9, UGT1A4
7
Hide members
10.2UGT1A4, UGT1A9
8
Hide members
10.2G6PD, BPNT1
9
Saturated fatty acid biosynthesis
Hide members
10.2BTD, PKLR
1010.0UGT1A8, UGT1A10, UGT1A3
11
Hide members
10.0UGT1A10, UGT1A6, UGT1A9
12
Hide members
9.9UGT1A9, UGT1A1, UGT1A10, UGT1A3
13
Hide members
9.9UGT1A1, UGT1A6, UGT1A4, UGT1A9
14
Hide members
9.6UGT1A9, UGT1A4, UGT1A8, UGT1A1, UGT1A10, UGT1A3
15
Hide members
9.5UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A3
169.5UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A10, UGT1A3
17
Acetaminophen metabolism
Hide members
9.4UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
18
Hide members
9.2UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
19
Hide members
9.1UGT1A3, UGT1A9, UGT1A7, UGT1A10, UGT1A5, UGT1A1
20
Hide members
9.1UGT1A7, UGT1A10, UGT1A5, UGT1A1, UGT1A6, UGT1A8
21
Hide members
8.9BPNT1, UGT1A9, UGT1A3, UGT1A7, UGT1A10, UGT1A5
22
Hide members
8.4UGT1A8, UGT1A4, UGT1A9, G6PD, BPNT1, HSD3B7

Compounds for genes affiliated with Neonatal Jaundice

About this section
Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 49PharmGKB, 2BitterDB, 59Tocris Bioscience
See all sources

Compounds related to Neonatal Jaundice according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1n-acetylbenzidine4410.4UGT1A4, UGT1A9, UGT1A1
2sn38 glucuronide4410.3UGT1A7, UGT1A1, UGT1A9
3acetaminophen glucuronide44 2411.3UGT1A1, UGT1A6, UGT1A9
4Ezogabine 1110.3UGT1A1, UGT1A9, UGT1A4, UGT1A3
5lamotrigine44 1111.3UGT1A1, UGT1A4, UGT1A6, UGT1A3
64-methylumbelliferone4410.2UGT1A6, UGT1A1, UGT1A9
71-naphthol4410.2UGT1A6, UGT1A9, UGT1A1
8udp glucuronic acid4410.2UGT1A8, UGT1A6, UGT1A10, UGT1A1
9benzidine4410.2UGT1A6, UGT1A1, UGT1A9, UGT1A4
10n-hydroxy-n-acetylbenzidine4410.2UGT1A9, UGT1A4
11phenol44 2411.2G6PD, UGT1A1, UGT1A6, UGT1A9
12trifluoperazine44 28 1112.2UGT1A4, UGT1A9, UGT1A6, UGT1A1
13etodolac44 1111.1UGT1A9, UGT1A10, UGT1A3
14p-nitrophenol44 1111.1UGT1A9, UGT1A3, UGT1A4, UGT1A1, UGT1A6
15mycophenolic acid44 49 1112.1UGT1A9, UGT1A8, UGT1A1, UGT1A10, UGT1A7
16diclofenac44 28 49 1113.1UGT1A3, UGT1A1, UGT1A6, UGT1A4, UGT1A9
17mycophenolate mofetil44 49 1112.1UGT1A8, UGT1A10, UGT1A1, UGT1A9
18phip4410.0UGT1A9, UGT1A1, UGT1A4
19benzo(a)pyrene4410.0UGT1A1, UGT1A6, UGT1A7, UGT1A9
20uridine44 11 2412.0UGT1A6, UGT1A4, UGT1A9, UGT1A1, UGT1A7
21irinotecan44 49 1112.0UGT1A9, UGT1A7, UGT1A1, UGT1A6
22amine4410.0UGT1A3, UGT1A1, UGT1A7, UGT1A4
23flurbiprofen44 28 49 1112.9UGT1A1, UGT1A3, UGT1A9
24morphine44 49 28 1112.9UGT1A1, UGT1A9, UGT1A8, UGT1A6, UGT1A4, UGT1A3
25tamoxifen44 49 28 1112.9UGT1A1, G6PD, UGT1A9, UGT1A4, UGT1A6, UGT1A3
26glucuronide449.9UGT1A3, UGT1A7, UGT1A9, UGT1A4, UGT1A6, UGT1A1
27acetaminophen44 2 49 11 2413.9G6PD, UGT1A1, UGT1A4, UGT1A9, UGT1A6, UGT1A10
28uridine diphosphate449.8UGT1A9, UGT1A7, UGT1A3, UGT1A10, UGT1A1, UGT1A6
29n-hydroxy phip449.8UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
30propofol44 49 1111.8UGT1A4, UGT1A9, UGT1A6, UGT1A1, UGT1A10, UGT1A8
31troglitazone44 28 59 1112.8UGT1A4, UGT1A1, UGT1A3, UGT1A10, UGT1A6, UGT1A8
32buprenorphine44 28 1111.7UGT1A9, UGT1A1, UGT1A3
33ethyl glucuronide44 2410.7UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10, UGT1A7
34cotinine44 2410.7UGT1A9, UGT1A8, UGT1A1, UGT1A6, UGT1A10, UGT1A7
35imipramine44 49 28 11 2413.7UGT1A4, UGT1A6, UGT1A7, UGT1A9, UGT1A1, UGT1A8
36nicotine44 49 28 1112.6UGT1A4, UGT1A8, UGT1A9, UGT1A1, UGT1A10, UGT1A7
37androsterone glucuronide44 2410.6UGT1A5, UGT1A10, UGT1A7, UGT1A3, UGT1A1, UGT1A6
383-alpha-androstanediol glucuronide44 2410.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
39etiocholanolone44 2410.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
40estriol28 11 2411.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
41estrone44 28 11 2412.6UGT1A7, UGT1A3, UGT1A10, UGT1A5, UGT1A1, UGT1A9
422-methoxyestradiol44 59 2411.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
43(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)249.6UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A5
44bilirubin diglucuronide44 2410.6UGT1A10, UGT1A7, UGT1A3, UGT1A5, UGT1A1, UGT1A6
45aldosterone 18-glucuronide44 2410.5UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
46codeine44 49 28 11 2413.5UGT1A3, UGT1A7, UGT1A9, UGT1A4, UGT1A8, UGT1A6
47valproic acid44 49 11 2412.5UGT1A3, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
48testosterone44 59 11 2412.4UGT1A7, UGT1A9, UGT1A10, UGT1A3, G6PD, UGT1A4
49estradiol44 11 2411.3UGT1A6, UGT1A9, UGT1A8, UGT1A4, UGT1A7, UGT1A1
50retinoic acid44 2410.3UGT1A9, UGT1A8, UGT1A3, UGT1A4, UGT1A6, UGT1A1

GO Terms for genes affiliated with Neonatal Jaundice

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Neonatal Jaundice according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intracellular membrane-bounded organelleGO:0432319.4G6PD, UGT1A9, UGT1A8, UGT1A6, UGT1A5
2integral to membraneGO:0160218.8UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A5, UGT1A10
3endoplasmic reticulum membraneGO:0057898.8HMOX2, HSD3B7, UGT1A9, UGT1A4, UGT1A8, UGT1A6

Biological processes related to Neonatal Jaundice according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1porphyrin-containing compound metabolic processGO:00677810.2HMOX2, UGT1A1
2negative regulation of steroid metabolic processGO:04593910.2UGT1A8, UGT1A1
3cellular glucuronidationGO:05269510.1UGT1A4, UGT1A6, UGT1A1, UGT1A10
4negative regulation of fatty acid metabolic processGO:04592210.1UGT1A9, UGT1A8, UGT1A7
5coumarin metabolic processGO:00980410.0UGT1A7, UGT1A8
6negative regulation of catalytic activityGO:04308610.0UGT1A7, UGT1A1, UGT1A8, UGT1A9
7flavone metabolic processGO:05155210.0UGT1A7, UGT1A9, UGT1A8, UGT1A1, UGT1A10
8xenobiotic glucuronidationGO:05269710.0UGT1A9, UGT1A8, UGT1A1, UGT1A7, UGT1A3
9flavonoid glucuronidationGO:05269610.0UGT1A9, UGT1A8, UGT1A1, UGT1A7, UGT1A3
10retinoic acid metabolic processGO:04257310.0UGT1A9, UGT1A8, UGT1A1, UGT1A7, UGT1A3
11drug metabolic processGO:01714410.0UGT1A7, UGT1A1, UGT1A8, UGT1A9
12metabolic processGO:0081529.9UGT1A3, UGT1A10, UGT1A5, UGT1A6, UGT1A9
13heme catabolic processGO:0421679.9HMOX2, UGT1A1
14xenobiotic metabolic processGO:0068059.7BPNT1, UGT1A9, UGT1A4, UGT1A6, UGT1A1, UGT1A5
15small molecule metabolic processGO:0442819.1UGT1A9, G6PD, BPNT1, HSD3B7, UGT1A4, UGT1A6

Molecular functions related to Neonatal Jaundice according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1steroid bindingGO:00549610.2UGT1A1, UGT1A8
2enzyme inhibitor activityGO:0048579.5UGT1A9, UGT1A8, UGT1A1, UGT1A7
3retinoic acid bindingGO:0019729.4UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
4enzyme bindingGO:0198999.3UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
5glucuronosyltransferase activityGO:0150209.3UGT1A3, UGT1A9, UGT1A7, UGT1A10, UGT1A5, UGT1A1
6protein heterodimerization activityGO:0469829.2UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1, UGT1A10
7protein homodimerization activityGO:0428039.1G6PD, UGT1A9, UGT1A4, UGT1A8, UGT1A6, UGT1A1

Products for genes affiliated with Neonatal Jaundice

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neonatal Jaundice

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet