MCID: NNT004
MIFTS: 33

Neonatal Respiratory Failure

Categories: Fetal diseases, Respiratory diseases

Aliases & Classifications for Neonatal Respiratory Failure

MalaCards integrated aliases for Neonatal Respiratory Failure:

Name: Neonatal Respiratory Failure 12 14 69
Respiratory Failure of Newborn 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11161
ICD10 32 P28.5
ICD9CM 34 770.84
SNOMED-CT 64 206317005 95619009
UMLS 69 C0521648

Summaries for Neonatal Respiratory Failure

MalaCards based summary : Neonatal Respiratory Failure, also known as respiratory failure of newborn, is related to respiratory failure and interstitial lung disease. An important gene associated with Neonatal Respiratory Failure is ABCA3 (ATP Binding Cassette Subfamily A Member 3), and among its related pathways/superpathways are Diseases of metabolism and Surfactant metabolism. Affiliated tissues include lung, brain and kidney, and related phenotypes are behavior/neurological and respiratory system

Related Diseases for Neonatal Respiratory Failure

Graphical network of the top 20 diseases related to Neonatal Respiratory Failure:



Diseases related to Neonatal Respiratory Failure

Symptoms & Phenotypes for Neonatal Respiratory Failure

MGI Mouse Phenotypes related to Neonatal Respiratory Failure:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.35 ABCA3 LMOD3 SFTPB SFTPC TRPS1
2 respiratory system MP:0005388 9.02 ABCA3 FOXF1 SFTPB SFTPC TRPS1

Drugs & Therapeutics for Neonatal Respiratory Failure

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of Bi-Level Positive Airway Pressure (BIPAP) Versus Non Invasive Positive Pressure Ventilation (NIPPV) for Neonatal Respiratory Failure Unknown status NCT01318824 Phase 3
2 Use of Orotracheal Continuous Positive Airway Pressure (CPAP) in Newborns With Respiratory Failure Unknown status NCT01379820 Phase 2, Phase 3
3 Non Invasive Ventilation Versus Continuous Positive Airway Pressure After Extubation of Very Low Birth Weight Infants. Unknown status NCT01778829 Phase 3
4 Pressure-limited Ventilation Versus Volume-targeted Ventilation in Preterm Newborns Completed NCT01531010
5 Trial of Weaning by Synchronized Ventilation Completed NCT01376544
6 Clinical Interventions in Respiratory Distress Syndrome and Neonatal Lung Injury - SCOR in Lung Biology and Diseases in Infants and Children Completed NCT00005683
7 Development of Modified Combined Apgar Scoring System for Evaluation of Infants in the Delivery Room Recruiting NCT03166826
8 Validation of a Novel Oxygen Consumption Measurement Technique in Neonates Recruiting NCT03154112
9 Hypothermia During ECMO to Decrease Brain Injury Withdrawn NCT01675388

Search NIH Clinical Center for Neonatal Respiratory Failure

Genetic Tests for Neonatal Respiratory Failure

Anatomical Context for Neonatal Respiratory Failure

MalaCards organs/tissues related to Neonatal Respiratory Failure:

38
Lung, Brain, Kidney

Publications for Neonatal Respiratory Failure

Articles related to Neonatal Respiratory Failure:

(show top 50) (show all 83)
# Title Authors Year
1
Admission volume is associated with mortality of neonatal respiratory failure in emerging neonatal intensive care units. ( 29385861 )
2018
2
Double aortic arch presenting as neonatal respiratory failure in the delivery room. ( 29248031 )
2018
3
The most frequent ABCA3 nonsense mutation -p.Tyr1515* (Y1515X) causing lethal neonatal respiratory failure in a term neonate. ( 28808495 )
2017
4
Neonatal Respiratory Failure Caused by Congenital Diffuse Intrinsic Pontine Glioma. ( 28116951 )
2017
5
Lung Rest During Extracorporeal Membrane Oxygenation for Neonatal Respiratory Failure-Practice Variations and Outcomes. ( 28504997 )
2017
6
Venoarterial extracorporeal life support for neonatal respiratory failure: indications and impact on mortality. ( 27984316 )
2016
7
Mortality of Neonatal Respiratory Failure from Chinese Northwest NICU Network. ( 27651118 )
2016
8
Neonatal respiratory failure due to ABCA3 deficiency. ( 28038995 )
2016
9
Effect of Change of Mechanical Ventilation Position on the Treatment of Neonatal Respiratory Failure. ( 25647746 )
2015
10
Successful primary use of VVDL+V ECMO with cephalic drain in neonatal respiratory failure. ( 26562372 )
2015
11
Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption. ( 26252542 )
2015
12
Exercise capacity, daily activity, and severity of fatigue in term born young adults after neonatal respiratory failure. ( 22724460 )
2014
13
Venoarterial versus venovenous ECMO for neonatal respiratory failure. ( 24580762 )
2014
14
Comparison of High Frequency Positive Pressure Mechanical Ventilation (HFPPV) With Conventional Method in the Treatment of Neonatal Respiratory Failure. ( 23983995 )
2013
15
Successful treatment of neonatal respiratory failure caused by a novel surfactant protein C p.Cys121Gly mutation with hydroxychloroquine. ( 23719253 )
2013
16
The pulmonary circulation in neonatal respiratory failure. ( 22954275 )
2012
17
Morbidity and mortality of neonatal respiratory failure in China: surfactant treatment in very immature infants. ( 22331337 )
2012
18
Gestational diabetes: a strong independent risk factor for severe neonatal respiratory failure after 34 weeks. ( 21170541 )
2011
19
Acute management of neonatal respiratory failure due to crossed ectopic obstructed megaureter in a duplicated pelvic kidney. ( 21050823 )
2011
20
Fatal neonatal respiratory failure in an infant with congenital hypothyroidism due to haploinsufficiency of the NKX2-1 gene: alteration of pulmonary surfactant homeostasis. ( 20584796 )
2011
21
Rhizomelic chondrodysplasia punctata type 1 and fulminant neonatal respiratory failure, a case report and discussion of pathophysiology. ( 22052861 )
2011
22
Mortality of neonatal respiratory failure related to socioeconomic factors in Hebei province of China. ( 21150226 )
2011
23
Extracorporeal membrane oxygenation and term neonatal respiratory failure deaths in the United Kingdom compared with the United States: 1999 to 2005. ( 19593243 )
2010
24
Neonatal respiratory failure due to a novel mutation in the surfactant protein C gene. ( 20118944 )
2010
25
Extracorporeal membrane oxygenation for the treatment of neonatal respiratory failure. ( 19713207 )
2009
26
Extracorporeal membrane oxygenation for neonatal respiratory failure. ( 19712500 )
2009
27
Neonatal respiratory failure: a 12-month clinical epidemiologic study from 2004 to 2005 in China. ( 18450855 )
2008
28
Clinical correlations and pulmonary function at 8 years of age after severe neonatal respiratory failure. ( 17654569 )
2007
29
Continuous negative extrathoracic pressure (CNEP) in neonatal respiratory failure: correction. ( 16740893 )
2006
30
Ototoxic drugs and sensorineural hearing loss following severe neonatal respiratory failure. ( 16449030 )
2006
31
ABCA3 deficiency: neonatal respiratory failure and interstitial lung disease. ( 17142158 )
2006
32
Neonatal respiratory failure associated with mutation in the surfactant protein C gene. ( 16355106 )
2006
33
ECMO for neonatal respiratory failure. ( 15921148 )
2005
34
[Neonatal respiratory failure associated with mutation in the surfactant protein C gene]. ( 15737281 )
2005
35
Long-term pulmonary sequelae in children who were treated with extracorporeal membrane oxygenation for neonatal respiratory failure. ( 15520110 )
2004
36
Acinar dysplasia: a rare cause of neonatal respiratory failure. ( 15174801 )
2004
37
Venovenous extracorporeal membrane oxygenation in neonatal respiratory failure: does routine, cephalad jugular drainage improve outcome? ( 15136997 )
2004
38
Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the US. ( 14654622 )
2003
39
Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States. ( 14654609 )
2003
40
Late-onset, progressive sensorineural hearing loss after severe neonatal respiratory failure. ( 11981395 )
2002
41
Neonatal respiratory failure. ( 12011671 )
2002
42
Epidemiology of neonatal respiratory failure in the United States: projections from California and New York. ( 11673202 )
2001
43
Acute neonatal respiratory failure and Chlamydia trachomatis. ( 11287694 )
2001
44
State of the art. Neonatal respiratory failure. ( 10855113 )
1999
45
Experimental neonatal respiratory failure induced by lysophosphatidylcholine: effect of surfactant treatment. ( 9931201 )
1999
46
Intratracheal pulmonary ventilation in neonatal respiratory failure. ( 9934880 )
1999
47
Which interventions for neonatal respiratory failure are effective? ( 9575272 )
1998
48
Alveolar capillary dysplasia with misalignment of the pulmonary veins: a rare but fatal cause of neonatal respiratory failure. ( 9880707 )
1998
49
Continuous negative extrathoracic pressure in neonatal respiratory failure. ( 8951269 )
1996
50
Early measurement of lung volume--a useful discriminator of neonatal respiratory failure severity. ( 8746375 )
1996

Variations for Neonatal Respiratory Failure

Expression for Neonatal Respiratory Failure

Search GEO for disease gene expression data for Neonatal Respiratory Failure.

Pathways for Neonatal Respiratory Failure

Pathways related to Neonatal Respiratory Failure according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.14 SFTPB SFTPC
2
Show member pathways
10.43 ABCA3 SFTPB SFTPC
3
Show member pathways
10.35 SFTPB SFTPC

GO Terms for Neonatal Respiratory Failure

Cellular components related to Neonatal Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 clathrin-coated endocytic vesicle GO:0045334 9.26 SFTPB SFTPC
2 lamellar body GO:0042599 9.16 SFTPB SFTPC
3 multivesicular body lumen GO:0097486 8.96 SFTPB SFTPC
4 alveolar lamellar body GO:0097208 8.62 ABCA3 SFTPB

Biological processes related to Neonatal Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.16 FOXF1 SFTPB
2 respiratory gaseous exchange GO:0007585 8.96 SFTPB SFTPC
3 cellular protein metabolic process GO:0044267 8.8 ABCA3 SFTPB SFTPC

Molecular functions related to Neonatal Respiratory Failure according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001228 8.62 FOXF1 TRPS1

Sources for Neonatal Respiratory Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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