Aliases & Classifications for Neonatal Stroke

MalaCards integrated aliases for Neonatal Stroke:

Name: Neonatal Stroke 37 49 69
Perinatal Arterial Ischemic Stroke 49
Perinatal Ischemic Stroke 49
Neonatal Ischemic Stroke 49
Perinatal Stroke 49
Nis 49

Classifications:



External Ids:

UMLS 69 C1299567

Summaries for Neonatal Stroke

CDC : 3 NIOSH Pocket Guide to Chemical Hazards Exposure limits, Respirator Recommendations, First Aid, more... The Pocket Guide is a source of general industrial hygiene information on several hundred chemicals/classes found in the work environment. Key data provided for each chemical/substance includes name (including synonyms/trade names), structure/formula, CAS/RTECS Numbers, DOT ID, conversion factors, exposure limits, IDLH, chemical and physical properties, measurement methods, personal protection, respirator recommendations, symptoms, and first aid.

MalaCards based summary : Neonatal Stroke, also known as perinatal arterial ischemic stroke, is related to protein c deficiency and thrombophilia. An important gene associated with Neonatal Stroke is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Darbepoetin alfa and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include Bone, brain and bone, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 72 Neonatal Stroke, similar to a stroke which occurs in adults, is defined as a disturbance to the blood... more...

Related Diseases for Neonatal Stroke

Diseases related to Neonatal Stroke via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 protein c deficiency 28.8 MTHFR PROC
2 thrombophilia 28.7 MTHFR PROC SERPINE1
3 thrombosis 28.6 MTHFR PROC SERPINE1
4 neutropenia, nonimmune chronic idiopathic, of adults 11.6
5 cortical blindness 11.1
6 extrinsic allergic alveolitis 11.0
7 idiopathic neutropenia 10.9
8 adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia 10.9
9 thyroiditis 10.3
10 blood group, i system 10.3
11 thyroid cancer 10.2
12 hypothyroidism 10.1
13 inferior vena cava interruption 10.0 MTHFR SERPINE1
14 amaurosis fugax 10.0 MTHFR SERPINE1
15 livedoid vasculopathy 10.0 MTHFR SERPINE1
16 cryptogenic cirrhosis 10.0 MTHFR SERPINE1
17 retinal artery occlusion 10.0 MTHFR SERPINE1
18 buerger disease 10.0 MTHFR SERPINE1
19 lemierre's syndrome 10.0 MTHFR SERPINE1
20 thrombophlebitis 10.0 MTHFR SERPINE1
21 cerebritis 10.0
22 portal vein thrombosis 10.0 MTHFR SERPINE1
23 hepatic vascular disease 10.0 MTHFR SERPINE1
24 retinal vein occlusion 9.9 MTHFR SERPINE1
25 congenital hypothyroidism 9.9
26 prostatitis 9.9
27 thrombophilia due to activated protein c resistance 9.9 MTHFR SERPINE1
28 osteonecrosis 9.9 MTHFR SERPINE1
29 homocysteinemia 9.9 MTHFR SERPINE1
30 pulmonary embolism 9.9 MTHFR SERPINE1
31 hypoxia 9.9
32 arteries, anomalies of 9.8 MTHFR SERPINE1
33 neutrophil migration 9.8
34 goiter 9.8
35 melanoma 9.8
36 meningococcemia 9.8 PROC SERPINE1
37 ischemia 9.8
38 neuronitis 9.8
39 blood protein disease 9.8 MTHFR PROC
40 hellp syndrome 9.8 MTHFR SERPINE1
41 marantic endocarditis 9.8 MTHFR PROC
42 cerebrovascular disease 9.7 MTHFR SERPINE1
43 vein disease 9.7 MTHFR PROC
44 intracranial hypertension 9.7 AQP4 MTHFR SERPINE1
45 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.7
46 cerebral palsy 9.7
47 cerebral artery occlusion 9.7
48 encephalopathy 9.7
49 neonatal hypoxic and ischemic brain injury 9.7
50 stroke, ischemic 9.7 AQP4 MTHFR SERPINE1

Graphical network of the top 20 diseases related to Neonatal Stroke:



Diseases related to Neonatal Stroke

Symptoms & Phenotypes for Neonatal Stroke

MGI Mouse Phenotypes related to Neonatal Stroke:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.35 AQP4 CTF1 MTHFR PROC SERPINE1
2 homeostasis/metabolism MP:0005376 9.02 AQP4 CTF1 MTHFR PROC SERPINE1

Drugs & Therapeutics for Neonatal Stroke

Drugs for Neonatal Stroke (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Darbepoetin alfa Approved, Investigational Phase 2 209810-58-2, 11096-26-7
2 Hematinics Phase 2
3 Passionflower Nutraceutical Phase 1, Phase 2
4
Bumetanide Approved Phase 1 28395-03-1 2471
5
Phenobarbital Approved, Investigational Phase 1 50-06-6 4763
6 Anticonvulsants Phase 1
7 Central Nervous System Depressants Phase 1
8 Cytochrome P-450 CYP3A Inducers Phase 1
9 diuretics Phase 1
10 Excitatory Amino Acid Antagonists Phase 1
11 Excitatory Amino Acids Phase 1
12 GABA Agents Phase 1
13 GABA Modulators Phase 1
14 Hypnotics and Sedatives Phase 1
15 Natriuretic Agents Phase 1
16 Neurotransmitter Agents Phase 1
17 Sodium Potassium Chloride Symporter Inhibitors Phase 1
18
Thrombin Approved, Investigational
19
Menthol Approved 2216-51-5 16666
20 Pharmaceutical Solutions

Interventional clinical trials:

(show all 18)

# Name Status NCT ID Phase Drugs
1 Modulation of Brain Plasticity After Perinatal Stroke Unknown status NCT01189058 Phase 2, Phase 3
2 Stimulation for Perinatal Stroke Optimizing Recovery Trajectories Recruiting NCT03216837 Phase 2, Phase 3
3 Enhancing Motor Plasticity After Perinatal Stroke Using tDCS Completed NCT02170285 Phase 2
4 Darbepoetin for Ischemic Neonatal Stroke to Augment Regeneration Recruiting NCT03171818 Phase 2 Darbepoetin Alfa;Saline
5 Perinatal Arterial Stroke Treated With Stromal Cells Intranasally Not yet recruiting NCT03356821 Phase 1, Phase 2
6 Safety of Autologous Human Umbilical Cord Blood Treatment for Perinatal Arterial Ischemic Stroke Suspended NCT02460484 Phase 1, Phase 2
7 Transcranial Magnetic Stimulation in Children With Stroke Completed NCT01637129 Phase 1
8 Pilot Study of Bumetanide for Newborn Seizures Active, not recruiting NCT00830531 Phase 1 Bumetanide;Normal Saline as Placebo
9 Umbilical Cord Blood in the Treatment of Stroke in Children. Withdrawn NCT01700166 Phase 1
10 Early Determinants of Multidimensional Outcome at School Age After Neonatal Arterial Ischemic Stroke Completed NCT02511249
11 Protein Supplementation in Infants With Brain Injury Completed NCT01936246
12 Study of Abnormal Blood Clotting in Children With Stroke Completed NCT00001927
13 Perinatal Stroke: Understanding Brain Reorganization Recruiting NCT02743728
14 Intensive Motor Training After Perinatal Stroke to Enhance Walking Recruiting NCT01773369
15 Early Intervention in Infants With Perinatal Stroke Recruiting NCT02720432
16 National Egyptian Network Pediatric Stroke and Hemiplegia Registry Recruiting NCT02129491
17 Quantitative Assessment of Sucking for Early Diagnosis of Brain Injury in Infants at High Risk Recruiting NCT03246243
18 FES in Young Children With Perinatal Stroke Not yet recruiting NCT02975180

Search NIH Clinical Center for Neonatal Stroke

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Neonatal Stroke cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Neonatal Stroke:
MultiStem
Embryonic/Adult Cultured Cells Related to Neonatal Stroke:
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 22952736 21175285

Genetic Tests for Neonatal Stroke

Anatomical Context for Neonatal Stroke

MalaCards organs/tissues related to Neonatal Stroke:

38
Brain, Bone, Bone Marrow, Endothelial, Monocytes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Neonatal Stroke:
# Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Neonatal Stroke

Articles related to Neonatal Stroke:

(show top 50) (show all 94)
# Title Authors Year
1
Placental Pathology in Neonatal Stroke: A Retrospective Case-Control Study. ( 29397159 )
2018
2
Pathways for Neuroimaging of Neonatal Stroke. ( 28262550 )
2017
3
Role of seizure in neonatal stroke. ( 28562317 )
2017
4
Sexually Dimorphic Outcomes after Neonatal Stroke and Hypoxia-Ischemia. ( 29278365 )
2017
5
Variability in Clinical Presentation of Neonatal Stroke: Report of Four Cases. ( 28194288 )
2017
6
Neonatal stroke and haematuria: Questions. ( 28717936 )
2017
7
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats. ( 28518065 )
2017
8
Is there an excess of left-handedness after neonatal stroke? ( 28893386 )
2017
9
Neonatal stroke and haematuria: Answers. ( 28717939 )
2017
10
In Vivo Measurement of Cerebral Mitochondrial Metabolism Using Broadband Near Infrared Spectroscopy Following Neonatal Stroke. ( 26782250 )
2016
11
Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke. ( 27142685 )
2016
12
Are neonatal stroke and hypoxic-ischemic encephalopathy related? ( 27234275 )
2016
13
Does Contralesional Hand Function After Neonatal Stroke Only Depend on Lesion Characteristics? ( 27165960 )
2016
14
Lack of the scavenger receptor CD36 alters microglial phenotypes after neonatal stroke. ( 26223273 )
2015
15
Intranasal delivery of bone marrow mesenchymal stem cells improved neurovascular regeneration and rescued neuropsychiatric deficits after neonatal stroke in rats. ( 25647744 )
2015
16
Fetal hydrocephalus and neonatal stroke as the first presentation of protein C deficiency. ( 26250584 )
2015
17
Long term motor function after neonatal stroke: Lesion localization above all. ( 26512551 )
2015
18
A Primer for Nurses on Perinatal/Neonatal Stroke. ( 26264800 )
2015
19
Quality of life and functional outcome in early school-aged children after neonatal stroke: a prospective cohort study. ( 24503061 )
2014
20
Are we considering neonatal stroke early enough in our differential diagnosis? ( 25468618 )
2014
21
Neonatal stroke: a review of the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options. ( 24428836 )
2014
22
Effects of intravenous administration of umbilical cord blood CD34(+) cells in a mouse model of neonatal stroke. ( 24444827 )
2014
23
Stem cells for neonatal stroke- the future is here. ( 25120432 )
2014
24
Barrier mechanisms in neonatal stroke. ( 25426016 )
2014
25
Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke. ( 23539530 )
2013
26
A novel reproducible model of neonatal stroke in mice: comparison with a hypoxia-ischemia model. ( 23651512 )
2013
27
Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke. ( 23391775 )
2013
28
Neonatal stroke and progressive leukoencephalopathy in a child with an ACTA2 mutation. ( 22752479 )
2013
29
Do early MRI signals predict lesion size in a neonatal stroke rat model? ( 22555584 )
2013
30
Neonatal stroke causes poor midline motor behaviors and poor fine and gross motor skills during early infancy. ( 23291519 )
2013
31
Quantification of white matter injury following neonatal stroke with serial DTI. ( 23478641 )
2013
32
Brief update on hemodynamic responses in animal models of neonatal stroke and hypoxia-ischemia. ( 23830950 )
2013
33
Spatial attention can transfer to the contralateral hemisphere in neonatal stroke patients: a case report following hemispherectomy. ( 22512322 )
2013
34
Inhaled nitric oxide reduces brain damage by collateral recruitment in a neonatal stroke model. ( 22949477 )
2012
35
Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat. ( 22787045 )
2012
36
Neonatal stroke. ( 22933099 )
2012
37
Genetic deletion of CD36 enhances injury after acute neonatal stroke. ( 23280844 )
2012
38
Neonatal stroke associated with de novo antiphospholipid antibody and homozygous 1298C/C methylenetetrahydrofolate reductase mutation. ( 23162020 )
2012
39
Corticospinal tract integrity and motor function following neonatal stroke: a case study. ( 22776078 )
2012
40
Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke. ( 22285309 )
2012
41
Neonatal stroke. ( 21852256 )
2011
42
Early continuous video electroencephalography in neonatal stroke. ( 21087242 )
2011
43
Placental pathology in neonatal stroke. ( 21339263 )
2011
44
Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke. ( 20856166 )
2011
45
Magnetic resonance imaging (MRI) as a translational tool for the study of neonatal stroke. ( 21670390 )
2011
46
Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury. ( 20876509 )
2010
47
Altered fate of subventricular zone progenitor cells and reduced neurogenesis following neonatal stroke. ( 20453463 )
2010
48
Functional integration of new neurons into hippocampal networks and poststroke comorbidities following neonatal stroke in mice. ( 20708575 )
2010
49
Neonatal stroke. ( 21089737 )
2010
50
Lipoprotein (a), birth weight and neonatal stroke. ( 20428016 )
2010

Variations for Neonatal Stroke

Expression for Neonatal Stroke

Search GEO for disease gene expression data for Neonatal Stroke.

Pathways for Neonatal Stroke

GO Terms for Neonatal Stroke

Biological processes related to Neonatal Stroke according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of blood coagulation GO:0030195 8.62 PROC SERPINE1

Sources for Neonatal Stroke

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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