NIS
MCID: NNT024
MIFTS: 36

Neonatal Stroke (NIS) malady

Categories: Rare diseases

Aliases & Classifications for Neonatal Stroke

Aliases & Descriptions for Neonatal Stroke:

Name: Neonatal Stroke 38 50 69
Perinatal Arterial Ischemic Stroke 50
Perinatal Ischemic Stroke 50
Neonatal Ischemic Stroke 50
Perinatal Stroke 50
Nis 50

Classifications:



Summaries for Neonatal Stroke

CDC : 3 NIOSH Pocket Guide to Chemical Hazards Exposure limits, Respirator Recommendations, First Aid, more... The Pocket Guide is a source of general industrial hygiene information on several hundred chemicals/classes found in the work environment. Key data provided for each chemical/substance includes name (including synonyms/trade names), structure/formula, CAS/RTECS Numbers, DOT ID, conversion factors, exposure limits, IDLH, chemical and physical properties, measurement methods, personal protection, respirator recommendations, symptoms, and first aid.

MalaCards based summary : Neonatal Stroke, also known as perinatal arterial ischemic stroke, is related to neutropenia, nonimmune chronic idiopathic, of adults and cortical blindness. An important gene associated with Neonatal Stroke is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Magnesium Sulfate and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include Bone, brain and bone, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 71 Neonatal Stroke, similar to a stroke which occurs in adults, is defined as a disturbance to the blood... more...

Related Diseases for Neonatal Stroke

Diseases related to Neonatal Stroke via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Related Disease Score Top Affiliating Genes
1 neutropenia, nonimmune chronic idiopathic, of adults 11.4
2 cortical blindness 11.0
3 fanconi syndrome 10.8
4 idiopathic neutropenia 10.8
5 adult-onset non-insulinoma persistent hyperinsulinemic hypoglycemia 10.8
6 thyroiditis 10.3
7 thyroid cancer 10.1
8 absence of innominate vein 10.1 MTHFR SERPINE1
9 aminoaciduria 10.1 MTHFR SERPINE1
10 lubinsky syndrome 10.1 MTHFR SERPINE1
11 bullous skin disease 10.0 MTHFR SERPINE1
12 glutathionuria 10.0 MTHFR SERPINE1
13 lynch syndrome 10.0 MTHFR SERPINE1
14 arcus senilis 10.0 MTHFR SERPINE1
15 dysgammaglobulinemia 10.0 MTHFR SERPINE1
16 scar contracture 10.0 MTHFR SERPINE1
17 pregnancy loss, recurrent 1 10.0 MTHFR SERPINE1
18 pancreas adenocarcinoma 10.0 MTHFR SERPINE1
19 hypothyroidism 10.0
20 leukocyte disease 10.0 MTHFR SERPINE1
21 neurofibroma of the heart 10.0 MTHFR SERPINE1
22 mental retardation hypotonia skin hyperpigmentation 10.0 PROC SERPINE1
23 welander distal myopathy 9.9 MTHFR SERPINE1
24 mixed epithelial tumor of ovary 9.9 MTHFR PROC
25 ductal carcinoma in situ 9.9 MTHFR PROC
26 pyrimidine metabolic disorder 9.9 MTHFR SERPINE1
27 vaginal discharge 9.9 MTHFR PROC
28 breast cancer 9.9
29 alcoholic gastritis 9.9 MTHFR PROC
30 uterine corpus cancer 9.9 AQP4 MTHFR SERPINE1
31 acute proliferative glomerulonephritis 9.9 MTHFR SERPINE1
32 budd-chiari syndrome 9.9 AQP4 MTHFR SERPINE1
33 cerebritis 9.9
34 prostate cancer 9.8
35 prostatitis 9.8
36 congenital hypothyroidism 9.8
37 cervix small cell carcinoma 9.8 MTHFR SERPINE1
38 central congenital hypothyroidism 9.7 MTHFR PROC SERPINE1
39 hypoxia 9.7
40 neuronitis 9.7
41 goiter 9.7
42 melanoma 9.7
43 immunodeficiency, common variable, 6 9.7 MTHFR PROC SERPINE1
44 bone development disease 9.7 MTHFR PROC SERPINE1
45 giant papillary conjunctivitis 9.7 MTHFR PROC SERPINE1
46 myocardial infarction 9.7 CTF1 MTHFR SERPINE1
47 ischemia 9.7
48 thrombophilia 9.6
49 encephalopathy 9.6
50 cerebral palsy 9.6

Graphical network of the top 20 diseases related to Neonatal Stroke:



Diseases related to Neonatal Stroke

Symptoms & Phenotypes for Neonatal Stroke

MGI Mouse Phenotypes related to Neonatal Stroke:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.35 AQP4 CTF1 MTHFR PROC SERPINE1
2 homeostasis/metabolism MP:0005376 9.02 MTHFR PROC SERPINE1 AQP4 CTF1

Drugs & Therapeutics for Neonatal Stroke

Drugs for Neonatal Stroke (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 87)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Magnesium Sulfate Approved, Vet_approved Phase 3 7487-88-9 24083
2
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
3 tannic acid Approved, Nutraceutical Phase 3
4 Anticonvulsants Phase 3,Phase 1
5 Analgesics Phase 3
6 Anesthetics Phase 3,Phase 2
7 Anti-Arrhythmia Agents Phase 3
8 calcium channel blockers Phase 3
9 Calcium, Dietary Phase 3
10 Central Nervous System Depressants Phase 3,Phase 1
11 Peripheral Nervous System Agents Phase 3
12 Tocolytic Agents Phase 3
13 Hematinics Phase 3,Phase 1
14 Anti-Infective Agents Phase 3,Phase 1,Phase 2
15 Micronutrients Phase 3,Phase 1
16 Pharmaceutical Solutions Phase 3,Phase 1
17 Trace Elements Phase 3,Phase 1
18 Epoetin alfa Phase 3 113427-24-0
19 Anti-Infective Agents, Local Phase 3
20 cadexomer iodine Phase 3
21 Hormone Antagonists Phase 3
22 Hormones Phase 3
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
24
Iodine Phase 3 7553-56-2 807
25
Menthol Approved Phase 2 2216-51-5 16666
26
Triamcinolone Approved, Vet_approved Phase 1, Phase 2 124-94-7 31307
27
Acetylcysteine Approved, Investigational Phase 1, Phase 2 616-91-1 12035
28
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
29
Butyric Acid Experimental Phase 2 107-92-6 264
30 Protective Agents Phase 1, Phase 2
31 Neuroprotective Agents Phase 1, Phase 2
32 triamcinolone acetonide Phase 1, Phase 2
33 Triamcinolone diacetate Phase 1, Phase 2
34 Triamcinolone hexacetonide Phase 1, Phase 2
35 Antidotes Phase 1, Phase 2
36 Antioxidants Phase 1, Phase 2
37 Antiviral Agents Phase 1, Phase 2
38 Expectorants Phase 1, Phase 2
39 N-monoacetylcystine Phase 1, Phase 2
40 Respiratory System Agents Phase 1, Phase 2
41 Anti-Inflammatory Agents Phase 2
42 Cortisol succinate Phase 2
43 Hydrocortisone 17-butyrate 21-propionate Phase 2
44 Hydrocortisone acetate Phase 2
45 Hydrocortisone-17-butyrate Phase 2
46 Adrenergic Agents Phase 2
47 Antihypertensive Agents Phase 2
48 Neurotransmitter Agents Phase 2,Phase 1
49
Topiramate Approved Phase 1 97240-79-4 5284627
50
Levoleucovorin Approved Phase 1 68538-85-2

Interventional clinical trials:

(show top 50) (show all 62)
id Name Status NCT ID Phase
1 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT01763853 Phase 4
2 Modulation of Brain Plasticity After Perinatal Stroke Unknown status NCT01189058 Phase 2, Phase 3
3 Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial) Completed NCT00014989 Phase 3
4 Role of Citicoline in Treatment of Newborns With Hypoxic Ischemic Encephalopathy Recruiting NCT03181646 Phase 3
5 Is Peri-operative Hyperoxemia a Risk Factor for Postoperative Complications? Recruiting NCT02562781 Phase 3
6 Liberal Oxygenation Versus Conservative Oxygenation in ARDS Recruiting NCT02713451 Phase 3
7 Preterm Erythropoietin Neuroprotection Trial (PENUT Trial) Active, not recruiting NCT01378273 Phase 3
8 Study of Thyroid Hormones in Prematures Not yet recruiting NCT02103998 Phase 3
9 Enhancing Motor Plasticity After Perinatal Stroke Using tDCS Completed NCT02170285 Phase 2
10 Moderate Hypothermia in Neonatal Hypoxic Ischemic Encephalopathy Completed NCT02826941 Phase 2
11 The Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis Pilot Study (The POSEIDON-Pilot Study) Completed NCT01087996 Phase 1, Phase 2
12 The Transendocardial Autologous Cells (hMSC or hBMC) in Ischemic Heart Failure Trial (TAC-HFT) Completed NCT00768066 Phase 1, Phase 2
13 Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio) Completed NCT00724594 Phase 1, Phase 2
14 Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants Completed NCT00167544 Phase 2
15 Neuroprotective Effect of Autologous Cord Blood Combined With Therapeutic Hypothermia Following Neonatal Encephalopathy Recruiting NCT02551003 Phase 1, Phase 2
16 Darbepoetin for Ischemic Neonatal Stroke to Augment Regeneration Not yet recruiting NCT03171818 Phase 2
17 Safety of Autologous Human Umbilical Cord Blood Treatment for Perinatal Arterial Ischemic Stroke Suspended NCT02460484 Phase 1, Phase 2
18 Parenteral Phenoxybenzamine During Congenital Heart Disease Surgery Withdrawn NCT00770705 Phase 2
19 Preventing Brain Injury in Infants With Congenital Heart Disease Unknown status NCT01426542 Phase 1
20 Transcranial Magnetic Stimulation in Children With Stroke Completed NCT01637129 Phase 1
21 Does B Vitamin Supplementation Decrease Homocysteine Concentrations in Newborns Completed NCT00877227 Phase 1
22 Pilot Study of Bumetanide for Newborn Seizures Active, not recruiting NCT00830531 Phase 1
23 Umbilical Cord Blood in the Treatment of Stroke in Children. Withdrawn NCT01700166 Phase 1
24 Treatment of Acute Respiratory Distress Syndrome With Tenecteplase: A Dose Escalation Pilot Study Withdrawn NCT00431379 Phase 1
25 Effects of Positive End-expiratory Pressure and Tidal Volume on Fluid Responsiveness of Acute Respiratory Distress Syndrome Unknown status NCT01716962
26 Early Determinants of Multidimensional Outcome at School Age After Neonatal Arterial Ischemic Stroke Completed NCT02511249
27 Protein Supplementation in Infants With Brain Injury Completed NCT01936246
28 Study of Abnormal Blood Clotting in Children With Stroke Completed NCT00001927
29 Quality of Care of Children With Sickle Cell Disease (SCD) Screened at Birth in France Completed NCT03119922
30 Aneurysms and Carotid Artery Block in Newborns Completed NCT00646672
31 Changes in Cardiac Output During Delayed Umbilical Cord Clamping Completed NCT02195037
32 Detection and Quantification of Neonatal Intraventricular Hemorrhage Completed NCT01899651
33 Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE Syndrome Completed NCT01018082
34 Effects of Massage Therapy to Induce Sleep in Preterm Infants Completed NCT01354028
35 The Effects of Aerobic Water Exercise on Pregnancy Completed NCT01364506
36 Impact of Maternal Pomegranate Juice on Brain Injury in Infants With Intrauterine Growth Restriction (IUGR) Completed NCT00788866
37 Text Message Reminders for Influenza Vaccine in Pregnancy Completed NCT02428738
38 Effect of Coconut Oil Application in Reducing Water Loss From Skin of Premature Babies in First Week of Life (TEWL) Completed NCT01364948
39 Effect of Twice Daily Application of Coconut Oil in Reducing Water Loss From Skin of Premature Babies in First Week of Life Completed NCT01758068
40 Study of Shunt Flow Sensor Accuracy in Extra-ventricular Drains. Completed NCT01108965
41 Regulation of Cerebral Blood Flow in Very Low Birth Weight Infants Completed NCT00579943
42 The Effects of Massage Therapy on QOL in Youth/Young Adults With Cystic Fibrosis Completed NCT01729585
43 Wolman/CESD Natural History Chart Review and Longitudinal Follow-Up Completed NCT01884220
44 Perinatal Stroke: Understanding Brain Reorganization Recruiting NCT02743728
45 Intensive Motor Training After Perinatal Stroke to Enhance Walking Recruiting NCT01773369
46 Early Intervention in Infants With Perinatal Stroke Recruiting NCT02720432
47 National Egyptian Network Pediatric Stroke and Hemiplegia Registry Recruiting NCT02129491
48 Descriptive Analysis of Near Infrared Spectroscopy in Critically Ill and Injured Pediatric and Neonatal Patients Recruiting NCT02950181
49 Fabry Disease in Cerebrovascular Disease Recruiting NCT02859363
50 Prediction of Brain Injury in Premature Infants Recruiting NCT02814383

Search NIH Clinical Center for Neonatal Stroke

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Neonatal Stroke cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Neonatal Stroke:
MultiStem
Embryonic/Adult Cultured Cells Related to Neonatal Stroke:
Bone marrow-derived adherent progenitor cells (MultiStem) PMIDs: 22952736 21175285

Genetic Tests for Neonatal Stroke

Anatomical Context for Neonatal Stroke

MalaCards organs/tissues related to Neonatal Stroke:

39
Brain, Bone, Bone Marrow, Monocytes, Endothelial
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Neonatal Stroke:
id Tissue Anatomical CompartmentCell Relevance
1 Bone Bone Marrow Bone Marrow Stromal Cells Potential therapeutic candidate

Publications for Neonatal Stroke

Articles related to Neonatal Stroke:

(show top 50) (show all 85)
id Title Authors Year
1
Are neonatal stroke and hypoxic-ischemic encephalopathy related? ( 27234275 )
2016
2
In Vivo Measurement of Cerebral Mitochondrial Metabolism Using Broadband Near Infrared Spectroscopy Following Neonatal Stroke. ( 26782250 )
2016
3
Does Contralesional Hand Function After Neonatal Stroke Only Depend on Lesion Characteristics? ( 27165960 )
2016
4
Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke. ( 27142685 )
2016
5
Long term motor function after neonatal stroke: Lesion localization above all. ( 26512551 )
2015
6
Lack of the scavenger receptor CD36 alters microglial phenotypes after neonatal stroke. ( 26223273 )
2015
7
A Primer for Nurses on Perinatal/Neonatal Stroke. ( 26264800 )
2015
8
Intranasal delivery of bone marrow mesenchymal stem cells improved neurovascular regeneration and rescued neuropsychiatric deficits after neonatal stroke in rats. ( 25647744 )
2015
9
Fetal hydrocephalus and neonatal stroke as the first presentation of protein C deficiency. ( 26250584 )
2015
10
Quality of life and functional outcome in early school-aged children after neonatal stroke: a prospective cohort study. ( 24503061 )
2014
11
Stem cells for neonatal stroke- the future is here. ( 25120432 )
2014
12
Effects of intravenous administration of umbilical cord blood CD34(+) cells in a mouse model of neonatal stroke. ( 24444827 )
2014
13
Neonatal stroke: a review of the current evidence on epidemiology, pathogenesis, diagnostics and therapeutic options. ( 24428836 )
2014
14
Barrier mechanisms in neonatal stroke. ( 25426016 )
2014
15
Are we considering neonatal stroke early enough in our differential diagnosis? ( 25468618 )
2014
16
Neonatal stroke and progressive leukoencephalopathy in a child with an ACTA2 mutation. ( 22752479 )
2013
17
Spatial attention can transfer to the contralateral hemisphere in neonatal stroke patients: a case report following hemispherectomy. ( 22512322 )
2013
18
A novel reproducible model of neonatal stroke in mice: comparison with a hypoxia-ischemia model. ( 23651512 )
2013
19
Do early MRI signals predict lesion size in a neonatal stroke rat model? ( 22555584 )
2013
20
Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke. ( 23391775 )
2013
21
Neonatal stroke causes poor midline motor behaviors and poor fine and gross motor skills during early infancy. ( 23291519 )
2013
22
Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke. ( 23539530 )
2013
23
Brief update on hemodynamic responses in animal models of neonatal stroke and hypoxia-ischemia. ( 23830950 )
2013
24
Quantification of white matter injury following neonatal stroke with serial DTI. ( 23478641 )
2013
25
Inhaled nitric oxide reduces brain damage by collateral recruitment in a neonatal stroke model. ( 22949477 )
2012
26
Neonatal stroke. ( 22933099 )
2012
27
Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat. ( 22787045 )
2012
28
Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke. ( 22285309 )
2012
29
Genetic deletion of CD36 enhances injury after acute neonatal stroke. ( 23280844 )
2012
30
Neonatal stroke associated with de novo antiphospholipid antibody and homozygous 1298C/C methylenetetrahydrofolate reductase mutation. ( 23162020 )
2012
31
Corticospinal tract integrity and motor function following neonatal stroke: a case study. ( 22776078 )
2012
32
Magnetic resonance imaging (MRI) as a translational tool for the study of neonatal stroke. ( 21670390 )
2011
33
Placental pathology in neonatal stroke. ( 21339263 )
2011
34
Early continuous video electroencephalography in neonatal stroke. ( 21087242 )
2011
35
Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke. ( 20856166 )
2011
36
Neonatal stroke. ( 21852256 )
2011
37
Lipoprotein (a), birth weight and neonatal stroke. ( 20428016 )
2010
38
Neonatal stroke. ( 21089737 )
2010
39
Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury. ( 20876509 )
2010
40
Functional integration of new neurons into hippocampal networks and poststroke comorbidities following neonatal stroke in mice. ( 20708575 )
2010
41
Altered fate of subventricular zone progenitor cells and reduced neurogenesis following neonatal stroke. ( 20453463 )
2010
42
Poststroke subgranular and rostral subventricular zone proliferation in a mouse model of neonatal stroke. ( 19396874 )
2009
43
Diagnostic management of neonatal stroke. ( 19682962 )
2009
44
Erythropoietin sustains cognitive function and brain volume after neonatal stroke. ( 19672069 )
2009
45
Magnetic resonance imaging in neonatal stroke. ( 19632909 )
2009
46
Late emergence of cognitive deficits after unilateral neonatal stroke. ( 19423855 )
2009
47
Targeting autophagy to prevent neonatal stroke damage. ( 19713756 )
2009
48
Neonatal stroke is not a harmless condition. ( 19423850 )
2009
49
Fatal neonatal stroke from a prenatal cardiac thrombus. ( 18206798 )
2008
50
Animal models of neonatal stroke and response to erythropoietin and cardiotrophin-1. ( 18036763 )
2008

Variations for Neonatal Stroke

Expression for Neonatal Stroke

Search GEO for disease gene expression data for Neonatal Stroke.

Pathways for Neonatal Stroke

GO Terms for Neonatal Stroke

Biological processes related to Neonatal Stroke according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of blood coagulation GO:0030195 8.62 PROC SERPINE1

Sources for Neonatal Stroke

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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