NIS
MCID: NNT024
MIFTS: 50

Neonatal Stroke (NIS) malady

Rare diseases category
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Summaries for Neonatal Stroke

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Sources:
4CDC, 65Wikipedia, 33MalaCards
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CDC:4 NIOSH Pocket Guide to Chemical HazardsExposure limits, Respirator Recommendations, First Aid, more...The Pocket Guide is a source of general industrial hygiene information on several hundred chemicals/classes found in the work environment. Key data provided for each chemical/substance includes name (including synonyms/trade names), structure/formula, CAS/RTECS Numbers, DOT ID, conversion factors, exposure limits, IDLH, chemical and physical properties, measurement methods, personal protection, respirator recommendations, symptoms, and first aid.

MalaCards: Neonatal Stroke, also known as perinatal arterial ischemic stroke, is related to thrombophilia and thyroiditis. An important gene associated with Neonatal Stroke is CTF1 (cardiotrophin 1), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The drugs warfarin and warfarin sodium and the compounds acenocoumarol and ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow, and related mouse phenotypes are mortality/aging and growth/size/body.

Wikipedia:65 Neonatal Stroke, similar to a stroke which occurs in adults, is defined as a disturbance to the blood... more...

Aliases & Classifications for Neonatal Stroke

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Sources:
62UMLS, 43NIH Rare Diseases, 31LifeMap Discovery™
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Aliases & Descriptions:

neonatal stroke 43 31 62
perinatal arterial ischemic stroke 43
perinatal ischemic stroke 43
cerebrovascular accident 62
neonatal ischemic stroke 43
perinatal stroke 43
nis 43


Related Diseases for Neonatal Stroke

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neonatal Stroke via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 100)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophilia30.2SERPINE1, F5, MTHFR
2thyroiditis10.6
3thyroid cancer10.4
4cerebritis10.4
5cerebral sinovenous thrombosis10.3
6hypothyroidism10.3
7neuronitis10.3
8hypoxia10.3
9cortical blindness10.2
10ischemia10.2
11congenital hypothyroidism10.2
12breast cancer10.2
13prostate cancer10.2
14prostatitis10.2
15cerebral palsy10.1
16goiter10.1
17schizophrenia10.1
18arrhinia10.1
19idiopathic neutropenia10.1
20myelitis10.1AQP4
21branch retinal artery occlusion10.1F5
22intracranial hypertension10.1ALB
23dysfibrinogenemia10.1F5
24purpura fulminans10.1F5
25meningococcemia10.1F5
26eclampsia10.1MTHFR
27coronary thrombosis10.1SERPINE1
28brain edema10.0AQP4, ALB
29hepatic encephalopathy10.0ALB, AQP4
30ovarian hyperstimulation syndrome10.0ALB, F5
31central retinal vein occlusion10.0MTHFR, F5
32hepatic vein thrombosis10.0F5, MTHFR
33diamond-blackfan anemia10.0
34chorioamnionitis10.0
35down syndrome10.0
36moyamoya disease10.0
37nutritional deficiency disease10.0ALB, MTHFR
38retinal vein occlusion10.0F5, MTHFR
39blood protein disease10.0F5, MTHFR
40portal vein thrombosis10.0MTHFR, F5
41antithrombin iii deficiency10.0MTHFR, F5
42intracranial thrombosis10.0F5, MTHFR
43homocysteinemia10.0MTHFR, F5
44placental abruption10.0MTHFR, F5
45brain disease10.0ALB, AQP4
46homocystinuria10.0MTHFR, F5
47pregnancy loss10.0F5, MTHFR
48antiphospholipid syndrome10.0F5, MTHFR
49galactosemia10.0ALB, F5
50severe pre-eclampsia10.0SERPINE1, F5

Graphical network of the top 20 diseases related to Neonatal Stroke:



Diseases related to neonatal stroke

Symptoms for Neonatal Stroke

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Drugs & Therapeutics for Neonatal Stroke

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Neonatal Stroke

Search NIH Clinical Center for Neonatal Stroke

Inferred drug relations via UMLS62/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Neonatal Stroke cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Neonatal Stroke:
MultiStem
Embryonic/Adult Cultured Cells Related to Neonatal Stroke:
Bone marrow-derived adherent progenitor cells (MultiStem), PMID: 22952736

Genetic Tests for Neonatal Stroke

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Anatomical Context for Neonatal Stroke

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Sources:
31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Neonatal Stroke:

33
Brain, Bone, Bone marrow, Monocytes, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Neonatal Stroke:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Neonatal Stroke or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Neonatal Stroke:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.5F5, ALB, MTHFR, AQP4, SERPINE1
2MP:00053787.3SERPINE1, AQP4, MTHFR, F5, CTF1
3MP:00053767.0CTF1, F5, ALB, MTHFR, AQP4, SERPINE1

Publications for Neonatal Stroke

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Sources:
52PubMed
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Articles related to Neonatal Stroke:

(show top 50)    (show all 70)
idTitleAuthorsYear
1
Neonatal stroke causes poor midline motor behaviors and poor fine and gross motor skills during early infancy. (23291519)
2013
2
Neonatal stroke and progressive leukoencephalopathy in a child with an ACTA2 mutation. (22752479)
2013
3
Do early MRI signals predict lesion size in a neonatal stroke rat model? (22555584)
2013
4
Spatial attention can transfer to the contralateral hemisphere in neonatal stroke patients: a case report following hemispherectomy. (22512322)
2013
5
Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke. (23391775)
2013
6
Quantification of white matter injury following neonatal stroke with serial DTI. (23478641)
2013
7
Brief update on hemodynamic responses in animal models of neonatal stroke and hypoxia-ischemia. (23830950)
2013
8
Inhaled nitric oxide reduces brain damage by collateral recruitment in a neonatal stroke model. (22949477)
2012
9
Corticospinal tract integrity and motor function following neonatal stroke: a case study. (22776078)
2012
10
Neonatal stroke. (22933099)
2012
11
Genetic deletion of CD36 enhances injury after acute neonatal stroke. (23280844)
2012
12
Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat. (22787045)
2012
13
Neonatal stroke associated with de novo antiphospholipid antibody and homozygous 1298C/C methylenetetrahydrofolate reductase mutation. (23162020)
2012
14
Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke. (22285309)
2012
15
Placental pathology in neonatal stroke. (21339263)
2011
16
Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke. (20856166)
2011
17
Magnetic resonance imaging (MRI) as a translational tool for the study of neonatal stroke. (21670390)
2011
18
Early continuous video electroencephalography in neonatal stroke. (21087242)
2011
19
Lipoprotein (a), birth weight and neonatal stroke. (20428016)
2010
20
Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury. (20876509)
2010
21
Neonatal stroke. (21089737)
2010
22
Altered fate of subventricular zone progenitor cells and reduced neurogenesis following neonatal stroke. (20453463)
2010
23
Functional integration of new neurons into hippocampal networks and poststroke comorbidities following neonatal stroke in mice. (20708575)
2010
24
Neonatal stroke is not a harmless condition. (19423850)
2009
25
Diagnostic management of neonatal stroke. (19682962)
2009
26
Erythropoietin sustains cognitive function and brain volume after neonatal stroke. (19672069)
2009
27
Targeting autophagy to prevent neonatal stroke damage. (19713756)
2009
28
Neurogenesis and neuronal commitment following ischemia in a new mouse model for neonatal stroke. (18387598)
2008
29
Fatal neonatal stroke from a prenatal cardiac thrombus. (18206798)
2008
30
Animal models of neonatal stroke and response to erythropoietin and cardiotrophin-1. (18036763)
2008
31
Neonatal stroke. (18826811)
2008
32
Temporal and regional evolution of aquaporin-4 expression and magnetic resonance imaging in a rat pup model of neonatal stroke. (17622964)
2007
33
Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke. (17762200)
2007
34
Recovery from hemiparesis and unilateral spatial neglect after neonatal stroke. Case report and rehabilitation of an infant. (17364523)
2007
35
Early cognitive outcome after neonatal stroke. (17890410)
2007
36
Albumin reduces blood-brain barrier permeability but does not alter infarct size in a rat model of neonatal stroke. (17622953)
2007
37
Pathways of neonatal stroke and subclavian steal syndrome. (16632648)
2006
38
Expression of tumor necrosis factor alpha and neuronal apoptosis in the developing rat brain after neonatal stroke. (16797840)
2006
39
Gender differences in long-term beneficial effects of erythropoietin given after neonatal stroke in postnatal day-7 rats. (16581190)
2006
40
Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke. (16023639)
2005
41
Lasting cytotoxic edema as an indicator of irreversible brain damage: a case of neonatal stroke. (9802484)
1998
42
Factor V Leiden as a cause of hemiplegic cerebral palsy, neonatal stroke, and placental thrombosis? (9749620)
1998
43
Pneumothorax and neonatal stroke. (8837079)
1996
44
Neonatal stroke involving the middle cerebral artery in term infants: clinical presentation, EEG and imaging studies, and outcome. (7890125)
1995
45
Proton magnetic resonance spectroscopic imaging in neonatal stroke. (8552213)
1995
46
A new model of neonatal stroke: reversible middle cerebral artery occlusion in the rat pup. (7619184)
1995
47
Neonatal stroke: clinical characteristics and cerebral blood flow velocity measurements. (7702686)
1994
48
Fetomaternal hemorrhage as an etiology of neonatal stroke. (7880342)
1994
49
Neonatal stroke: description of patients and investigation into pathogenesis. (3072007)
1988
50
Outcome after neonatal stroke. (2426434)
1986

Variations for Neonatal Stroke

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Expression for genes affiliated with Neonatal Stroke

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neonatal Stroke

Search GEO for disease gene expression data for Neonatal Stroke.

Pathways for genes affiliated with Neonatal Stroke

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 55Reactome, 53QIAGEN, 54R&D Systems
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Pathways related to Neonatal Stroke according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.1F5, SERPINE1
2
Show member pathways
9.1F5, SERPINE1
3
Show member pathways
8.6SERPINE1, ALB, F5
4
Show member pathways
8.6SERPINE1, ALB, F5
5
Show member pathways
thioredoxin pathway38
8.5SERPINE1, MTHFR, ALB

Compounds for genes affiliated with Neonatal Stroke

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 24HMDB, 61Tocris Bioscience, 29IUPHAR
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Compounds related to Neonatal Stroke according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1acenocoumarol45 51 1111.8F5, ALB
2ceftriaxone45 1110.8F5, ALB
3Pyridoxine24 1110.7MTHFR, ALB
4antipyrine45 1110.7F5, ALB
55-methyltetrahydrofolate45 1110.7MTHFR, F5
6cystathionine459.7F5, MTHFR
7batroxobin459.6F5, SERPINE1
8ancrod459.5SERPINE1, F5
9fosinopril45 1110.5SERPINE1, ALB
10repaglinide51 45 1111.5SERPINE1, ALB
11ramipril45 1110.5SERPINE1, ALB
12valsartan45 61 29 1112.5SERPINE1, ALB
13perindopril45 51 1111.4SERPINE1, ALB
14irbesartan45 29 51 1112.4ALB, SERPINE1
15urea45 24 1111.4F5, AQP4, ALB
16tibolone459.4SERPINE1, F5
17cyproteroneacetate459.3SERPINE1, F5
18candesartan45 51 29 1112.3ALB, SERPINE1
19hydrochlorothiazide45 29 51 24 1113.3ALB, SERPINE1
20vitamin b6459.3MTHFR, F5, ALB
21warfarin45 51 24 1112.3MTHFR, ALB, F5
22vitamin b12459.2ALB, MTHFR, F5
23spironolactone45 61 29 51 1113.2ALB, SERPINE1
24enalapril45 51 1111.2ALB, SERPINE1
25folate459.2MTHFR, ALB, F5
26amlodipine45 51 24 1112.1SERPINE1, ALB
27desmopressin45 61 29 1112.1SERPINE1, F5
28mannitol45 1110.1SERPINE1, AQP4, ALB
29ascorbic acid45 2410.1ALB, MTHFR, F5
30mycophenolate mofetil45 51 1111.1ALB, F5, SERPINE1
31kininogen459.0SERPINE1, F5, ALB
32sodium dodecylsulfate459.0SERPINE1, F5, ALB
33tacrolimus45 51 1111.0F5, ALB, SERPINE1
34metformin45 51 1110.9SERPINE1, MTHFR, F5
35p00001458.9MTHFR, SERPINE1
36cyclophosphamide45 51 1110.9SERPINE1, MTHFR, F5
37aspirin45 51 29 2411.9SERPINE1, MTHFR, F5
38methotrexate51 45 1110.9ALB, SERPINE1, MTHFR
39diisopropylfluorophosphate458.8ALB, SERPINE1
40vitamin d458.7SERPINE1, MTHFR, ALB
41cysteine458.7F5, MTHFR, AQP4, ALB
42uric acid45 249.4SERPINE1, F5, ALB, MTHFR
43homocysteine45 249.4MTHFR, SERPINE1, ALB, F5
44fibrinogen458.4SERPINE1, F5, ALB, MTHFR
45creatinine458.4MTHFR, SERPINE1, ALB, F5
46aspartate458.4F5, MTHFR, ALB, SERPINE1
47heparin45 29 24 1111.4F5, ALB, MTHFR, SERPINE1
48testosterone45 61 24 1111.4MTHFR, F5, ALB, SERPINE1
49cholesterol45 29 24 1111.4SERPINE1, F5, ALB, MTHFR
50retinoic acid45 249.4F5, MTHFR, AQP4, SERPINE1

GO Terms for genes affiliated with Neonatal Stroke

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Sources:
16Gene Ontology
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Cellular components related to Neonatal Stroke according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.5SERPINE1, ALB, F5
2extracellular regionGO:0055768.2SERPINE1, ALB, F5, CTF1
3extracellular spaceGO:0056157.9SERPINE1, ALB, F5, CTF1

Biological processes related to Neonatal Stroke according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood circulationGO:0080159.0F5, MTHFR
2platelet degranulationGO:0025768.6F5, ALB, SERPINE1
3blood coagulationGO:0075968.6ALB, F5, SERPINE1
4platelet activationGO:0301688.5ALB, F5, SERPINE1

Molecular functions related to Neonatal Stroke according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.4F5, ALB

Products for genes affiliated with Neonatal Stroke

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Neonatal Stroke

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet