NIS
MCID: NNT024
MIFTS: 51

Neonatal Stroke (NIS) malady

Rare diseases category
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Summaries for Neonatal Stroke

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CDC:3 NIOSH Pocket Guide to Chemical HazardsExposure limits, Respirator Recommendations, First Aid, more...The Pocket Guide is a source of general industrial hygiene information on several hundred chemicals/classes found in the work environment. Key data provided for each chemical/substance includes name (including synonyms/trade names), structure/formula, CAS/RTECS Numbers, DOT ID, conversion factors, exposure limits, IDLH, chemical and physical properties, measurement methods, personal protection, respirator recommendations, symptoms, and first aid.

MalaCards based summary: Neonatal Stroke, also known as perinatal arterial ischemic stroke, is related to thrombophilia and thyroiditis. An important gene associated with Neonatal Stroke is CTF1 (cardiotrophin 1), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The drugs warfarin and warfarin sodium and the compounds acenocoumarol and ceftriaxone have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow, and related mouse phenotypes are mortality/aging and growth/size/body.

Wikipedia:65 Neonatal Stroke, similar to a stroke which occurs in adults, is defined as a disturbance to the blood... more...

Aliases & Classifications for Neonatal Stroke

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Neonatal Stroke, Aliases & Descriptions:

Name: Neonatal Stroke 30 42 62
Perinatal Arterial Ischemic Stroke 42
Perinatal Ischemic Stroke 42
Cerebrovascular Accident 62
 
Neonatal Ischemic Stroke 42
Perinatal Stroke 42
Nis 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Neonatal Stroke

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Diseases related to Neonatal Stroke via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1thrombophilia30.0SERPINE1, F5, MTHFR
2thyroiditis10.6
3thyroid cancer10.4
4myelitis10.4AQP4
5branch retinal artery occlusion10.4F5
6intracranial hypertension10.4ALB
7dysfibrinogenemia10.4F5
8meningococcemia10.4F5
9eclampsia10.4MTHFR
10cerebritis10.4
11cerebral sinovenous thrombosis10.3
12hypothyroidism10.3
13neuronitis10.3
14hypoxia10.3
15coronary thrombosis10.3SERPINE1
16cortical blindness10.2
17ischemia10.2
18prostate cancer10.2
19congenital hypothyroidism10.2
20breast cancer10.2
21prostatitis10.2
22brain edema10.2AQP4, ALB
23hepatic encephalopathy10.2ALB, AQP4
24ovarian hyperstimulation syndrome10.2ALB, F5
25central retinal vein occlusion10.2MTHFR, F5
26hepatic vein thrombosis10.2F5, MTHFR
27nutritional deficiency disease10.2ALB, MTHFR
28retinal vein occlusion10.2F5, MTHFR
29blood protein disease10.2F5, MTHFR
30portal vein thrombosis10.2MTHFR, F5
31antithrombin iii deficiency10.1MTHFR, F5
32intracranial thrombosis10.1F5, MTHFR
33homocysteinemia10.1MTHFR, F5
34placental abruption10.1MTHFR, F5
35cerebral palsy10.1
36schizophrenia10.1
37goiter10.1
38arrhinia10.1
39idiopathic neutropenia10.1
40brain disease10.1ALB, AQP4
41homocystinuria10.1MTHFR, F5
42pregnancy loss10.1F5, MTHFR
43antiphospholipid syndrome10.1F5, MTHFR
44galactosemia10.1ALB, F5
45severe pre-eclampsia10.1SERPINE1, F5
46peripheral vascular disease10.0ALB, SERPINE1
47diamond-blackfan anemia10.0
48down syndrome10.0
49moyamoya disease10.0
50chorioamnionitis10.0

Graphical network of the top 20 diseases related to Neonatal Stroke:



Diseases related to neonatal stroke

Symptoms for Neonatal Stroke

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Drugs & Therapeutics for Neonatal Stroke

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Drug clinical trials:

Search ClinicalTrials for Neonatal Stroke

Search NIH Clinical Center for Neonatal Stroke

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Neonatal Stroke cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Neonatal Stroke:
MultiStem
Embryonic/Adult Cultured Cells Related to Neonatal Stroke:
Bone marrow-derived adherent progenitor cells (MultiStem), PMID: 22952736

Genetic Tests for Neonatal Stroke

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Anatomical Context for Neonatal Stroke

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MalaCards organs/tissues related to Neonatal Stroke:

32
Brain, Bone, Bone marrow, Monocytes, Endothelial

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Neonatal Stroke:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Neonatal Stroke or affiliated genes

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MGI Mouse Phenotypes related to Neonatal Stroke:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.5F5, ALB, MTHFR, AQP4, SERPINE1
2MP:00053787.3SERPINE1, AQP4, MTHFR, F5, CTF1
3MP:00053767.0CTF1, F5, ALB, MTHFR, AQP4, SERPINE1

Publications for Neonatal Stroke

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Articles related to Neonatal Stroke:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
Neonatal stroke causes poor midline motor behaviors and poor fine and gross motor skills during early infancy. (23291519)
2013
2
Neonatal stroke and progressive leukoencephalopathy in a child with an ACTA2 mutation. (22752479)
2013
3
Do early MRI signals predict lesion size in a neonatal stroke rat model? (22555584)
2013
4
Spatial attention can transfer to the contralateral hemisphere in neonatal stroke patients: a case report following hemispherectomy. (22512322)
2013
5
Erythropoietin increases neurogenesis and oligodendrogliosis of subventricular zone precursor cells after neonatal stroke. (23391775)
2013
6
Quantification of white matter injury following neonatal stroke with serial DTI. (23478641)
2013
7
Brief update on hemodynamic responses in animal models of neonatal stroke and hypoxia-ischemia. (23830950)
2013
8
Inhaled nitric oxide reduces brain damage by collateral recruitment in a neonatal stroke model. (22949477)
2012
9
Corticospinal tract integrity and motor function following neonatal stroke: a case study. (22776078)
2012
10
Neonatal stroke. (22933099)
2012
11
Genetic deletion of CD36 enhances injury after acute neonatal stroke. (23280844)
2012
12
Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat. (22787045)
2012
13
Neonatal stroke associated with de novo antiphospholipid antibody and homozygous 1298C/C methylenetetrahydrofolate reductase mutation. (23162020)
2012
14
Placental pathology in neonatal stroke. (21339263)
2011
15
Melatonin promotes myelination by decreasing white matter inflammation after neonatal stroke. (20856166)
2011
16
Magnetic resonance imaging (MRI) as a translational tool for the study of neonatal stroke. (21670390)
2011
17
Early continuous video electroencephalography in neonatal stroke. (21087242)
2011
18
Lipoprotein (a), birth weight and neonatal stroke. (20428016)
2010
19
Neonatal stroke in mice causes long-term changes in neuronal Notch-2 expression that may contribute to prolonged injury. (20876509)
2010
20
Neonatal stroke. (21089737)
2010
21
Altered fate of subventricular zone progenitor cells and reduced neurogenesis following neonatal stroke. (20453463)
2010
22
Functional integration of new neurons into hippocampal networks and poststroke comorbidities following neonatal stroke in mice. (20708575)
2010
23
Neonatal stroke is not a harmless condition. (19423850)
2009
24
Diagnostic management of neonatal stroke. (19682962)
2009
25
Erythropoietin sustains cognitive function and brain volume after neonatal stroke. (19672069)
2009
26
Targeting autophagy to prevent neonatal stroke damage. (19713756)
2009
27
Neurogenesis and neuronal commitment following ischemia in a new mouse model for neonatal stroke. (18387598)
2008
28
Fatal neonatal stroke from a prenatal cardiac thrombus. (18206798)
2008
29
Animal models of neonatal stroke and response to erythropoietin and cardiotrophin-1. (18036763)
2008
30
Neonatal stroke. (18826811)
2008
31
Temporal and regional evolution of aquaporin-4 expression and magnetic resonance imaging in a rat pup model of neonatal stroke. (17622964)
2007
32
Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke. (17762200)
2007
33
Recovery from hemiparesis and unilateral spatial neglect after neonatal stroke. Case report and rehabilitation of an infant. (17364523)
2007
34
Early cognitive outcome after neonatal stroke. (17890410)
2007
35
Albumin reduces blood-brain barrier permeability but does not alter infarct size in a rat model of neonatal stroke. (17622953)
2007
36
Pathways of neonatal stroke and subclavian steal syndrome. (16632648)
2006
37
Expression of tumor necrosis factor alpha and neuronal apoptosis in the developing rat brain after neonatal stroke. (16797840)
2006
38
Gender differences in long-term beneficial effects of erythropoietin given after neonatal stroke in postnatal day-7 rats. (16581190)
2006
39
Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke. (16023639)
2005
40
Editorial comment--specificities of the neonatal stroke. (14631077)
2003
41
Lasting cytotoxic edema as an indicator of irreversible brain damage: a case of neonatal stroke. (9802484)
1998
42
Factor V Leiden as a cause of hemiplegic cerebral palsy, neonatal stroke, and placental thrombosis? (9749620)
1998
43
Pneumothorax and neonatal stroke. (8837079)
1996
44
Neonatal stroke involving the middle cerebral artery in term infants: clinical presentation, EEG and imaging studies, and outcome. (7890125)
1995
45
Proton magnetic resonance spectroscopic imaging in neonatal stroke. (8552213)
1995
46
A new model of neonatal stroke: reversible middle cerebral artery occlusion in the rat pup. (7619184)
1995
47
Neonatal stroke: clinical characteristics and cerebral blood flow velocity measurements. (7702686)
1994
48
Fetomaternal hemorrhage as an etiology of neonatal stroke. (7880342)
1994
49
Neonatal stroke: description of patients and investigation into pathogenesis. (3072007)
1988
50
Outcome after neonatal stroke. (2426434)
1986

Variations for Neonatal Stroke

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Expression for genes affiliated with Neonatal Stroke

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Expression patterns in normal tissues for genes affiliated with Neonatal Stroke

Search GEO for disease gene expression data for Neonatal Stroke.

Pathways for genes affiliated with Neonatal Stroke

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Pathways related to Neonatal Stroke according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.1F5, SERPINE1
2
Show member pathways
9.1F5, SERPINE1
3
Show member pathways
8.6SERPINE1, ALB, F5
4
Show member pathways
8.6SERPINE1, ALB, F5
5
Show member pathways
thioredoxin pathway37
8.5SERPINE1, MTHFR, ALB

Compounds for genes affiliated with Neonatal Stroke

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Compounds related to Neonatal Stroke according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1acenocoumarol44 50 1111.8F5, ALB
2ceftriaxone44 1110.8F5, ALB
3Pyridoxine24 1110.7MTHFR, ALB
4antipyrine44 1110.7F5, ALB
55-methyltetrahydrofolate44 1110.7MTHFR, F5
6cystathionine449.7F5, MTHFR
7batroxobin449.6F5, SERPINE1
8ancrod449.5SERPINE1, F5
9fosinopril44 1110.5SERPINE1, ALB
10repaglinide50 44 1111.5SERPINE1, ALB
11ramipril44 1110.5SERPINE1, ALB
12valsartan44 61 28 1112.5SERPINE1, ALB
13perindopril44 50 1111.4SERPINE1, ALB
14irbesartan44 28 50 1112.4ALB, SERPINE1
15urea44 24 1111.4F5, AQP4, ALB
16tibolone449.4SERPINE1, F5
17cyproteroneacetate449.3SERPINE1, F5
18candesartan44 50 28 1112.3ALB, SERPINE1
19hydrochlorothiazide44 28 50 24 1113.3ALB, SERPINE1
20vitamin b6449.3MTHFR, F5, ALB
21warfarin44 50 24 1112.3MTHFR, ALB, F5
22vitamin b12449.2ALB, MTHFR, F5
23spironolactone44 61 28 50 1113.2ALB, SERPINE1
24enalapril44 50 1111.2ALB, SERPINE1
25folate449.2MTHFR, ALB, F5
26amlodipine44 50 24 1112.1SERPINE1, ALB
27desmopressin44 61 28 1112.1SERPINE1, F5
28mannitol44 1110.1SERPINE1, AQP4, ALB
29ascorbic acid44 2410.1ALB, MTHFR, F5
30mycophenolate mofetil44 50 1111.1ALB, F5, SERPINE1
31kininogen449.0SERPINE1, F5, ALB
32sodium dodecylsulfate449.0SERPINE1, F5, ALB
33tacrolimus44 50 1111.0F5, ALB, SERPINE1
34metformin44 50 1110.9SERPINE1, MTHFR, F5
35p00001448.9MTHFR, SERPINE1
36cyclophosphamide44 50 1110.9SERPINE1, MTHFR, F5
37aspirin44 50 28 2411.9SERPINE1, MTHFR, F5
38methotrexate50 44 1110.9ALB, SERPINE1, MTHFR
39diisopropylfluorophosphate448.8ALB, SERPINE1
40vitamin d448.7SERPINE1, MTHFR, ALB
41cysteine448.7F5, MTHFR, AQP4, ALB
42uric acid44 249.4SERPINE1, F5, ALB, MTHFR
43homocysteine44 249.4MTHFR, SERPINE1, ALB, F5
44fibrinogen448.4SERPINE1, F5, ALB, MTHFR
45creatinine448.4MTHFR, SERPINE1, ALB, F5
46aspartate448.4F5, MTHFR, ALB, SERPINE1
47heparin44 28 24 1111.4F5, ALB, MTHFR, SERPINE1
48testosterone44 61 24 1111.4MTHFR, F5, ALB, SERPINE1
49cholesterol44 28 24 1111.4SERPINE1, F5, ALB, MTHFR
50retinoic acid44 249.4F5, MTHFR, AQP4, SERPINE1

GO Terms for genes affiliated with Neonatal Stroke

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Cellular components related to Neonatal Stroke according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.5SERPINE1, ALB, F5
2extracellular regionGO:0055768.2SERPINE1, ALB, F5, CTF1
3extracellular spaceGO:0056157.9SERPINE1, ALB, F5, CTF1

Biological processes related to Neonatal Stroke according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood circulationGO:0080159.0F5, MTHFR
2platelet degranulationGO:0025768.6F5, ALB, SERPINE1
3blood coagulationGO:0075968.6ALB, F5, SERPINE1
4platelet activationGO:0301688.5ALB, F5, SERPINE1

Molecular functions related to Neonatal Stroke according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.4F5, ALB

Products for genes affiliated with Neonatal Stroke

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  • Antibodies
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Sources for Neonatal Stroke

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet