NIS
MCID: NNT024
MIFTS: 40

Neonatal Stroke (NIS) malady

Summaries for Neonatal Stroke

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Sources:
3CDC, 63Wikipedia, 32MalaCards
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CDC:3 NIOSH Pocket Guide to Chemical HazardsExposure limits, Respirator Recommendations, First Aid, more... The Pocket Guide is a source of general industrial hygiene information on several hundred chemicals/classes found in the work environment. Key data provided for each chemical/substance includes name (including synonyms/trade names), structure/formula, CAS/RTECS Numbers, DOT ID, conversion factors, exposure limits, IDLH, chemical and physical properties, measurement methods, personal protection, respirator recommendations, symptoms, and first aid.

MalaCards: Neonatal Stroke, also known as perinatal arterial ischemic stroke, is related to cerebrovascular disease and myocardial infarction. An important gene associated with Neonatal Stroke is CTF1 (cardiotrophin 1), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The drugs warfarin and warfarin sodium and the compounds aspartate and tacrolimus have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow, and related mouse phenotypes are growth/size and homeostasis/metabolism.

Wikipedia:63 Neonatal Stroke, similar to a stroke which occurs in adults, is defined as a disturbance to the blood... more...

Aliases & Classifications for Neonatal Stroke

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Sources:
42NIH Rare Diseases, 30LifeMap Discovery™, 60UMLS
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Aliases & Descriptions:

neonatal stroke 42 30 60
perinatal arterial ischemic stroke 42
perinatal ischemic stroke 42
cerebrovascular accident 60
neonatal ischemic stroke 42
perinatal stroke 42
nis 42


Related Diseases for Neonatal Stroke

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neonatal Stroke via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 172)
idRelated DiseaseScoreTop Affiliating Genes
1cerebrovascular disease31.0MTHFR
2myocardial infarction30.8CTF1, F5, MTHFR, SERPINE1
3hypertension30.7ALB, MTHFR, F5, SERPINE1
4patent foramen ovale30.5F5
5acute myocardial infarction30.5CTF1, SERPINE1
6lupus erythematosus30.3F5
7arthritis30.3ALB
8rheumatoid arthritis30.3MTHFR
9protein c deficiency30.3MTHFR, SERPINE1, F5
10atherosclerosis30.3ALB, MTHFR, SERPINE1
11ischemia30.2CTF1, AQP4
12thrombophilia30.1F5, MTHFR, SERPINE1
13intracranial hypertension30.1ALB
14obesity30.1SERPINE1
15coronary thrombosis30.1SERPINE1
16eclampsia30.1MTHFR
17migraine30.1MTHFR
18hemorrhagic disease30.1SERPINE1
19retinal vein occlusion30.1MTHFR, F5
20antiphospholipid syndrome30.1MTHFR, F5
21antithrombin iii deficiency30.1MTHFR, F5
22brain disease30.1ALB, AQP4
23protein s deficiency30.1MTHFR, F5, SERPINE1
24diabetes mellitus30.1ALB, MTHFR, SERPINE1
25cadasil30.0AQP4, MTHFR, SERPINE1, F5
26hyperhomocysteinemia30.0F5, MTHFR, SERPINE1, ALB
27down syndrome30.0MTHFR
28brain edema29.9ALB, AQP4
29stroke, ischemic29.8MTHFR, AQP4, F5, SERPINE1
30thyroiditis10.5
31thyroid cancer10.4
32sneddon syndrome10.4
33sickle cell anemia10.4
34cerebritis10.3
35hypothyroidism10.3
36neuronitis10.2
37systemic lupus erythematosus10.2
38hemiplegia10.2
39testicular cancer10.2
40thalassemia10.2
41cortical blindness10.2
42congenital hypothyroidism10.2
43breast cancer10.2
44prostate cancer10.2
45prostatitis10.2
46cerebral palsy10.1
47goiter10.1
48idiopathic neutropenia10.1
49deficiency anemia10.1
50coronary artery disease10.1

Graphical network of the top 20 diseases related to Neonatal Stroke:



Diseases related to neonatal stroke

Clinical Features for Neonatal Stroke

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Drugs & Therapeutics for Neonatal Stroke

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Neonatal Stroke

Drug clinical trials:

Search ClinicalTrials for Neonatal Stroke

Search NIH Clinical Center for Neonatal Stroke

Search CenterWatch for Neonatal Stroke

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Neonatal Stroke cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Neonatal Stroke:
MultiStem
Embryonic/Adult Cultured Cells Related to Neonatal Stroke:
Bone marrow-derived adherent progenitor cells (MultiStem), PMID: 22952736

Genetic Tests for Neonatal Stroke

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Anatomical Context for Neonatal Stroke

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Neonatal Stroke:

32
Brain, Bone, Bone marrow

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Neonatal Stroke:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Neonatal Stroke or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Neonatal Stroke:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053787.6AQP4, SERPINE1, MTHFR, F5, CTF1
2MP:00053766.8AQP4, CTF1, F5, MTHFR, SERPINE1, ALB

Publications for Neonatal Stroke

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Genetic Variations for Neonatal Stroke

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Expression for genes affiliated with Neonatal Stroke

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neonatal Stroke

Search GEO for disease gene expression data for Neonatal Stroke.

Pathways for genes affiliated with Neonatal Stroke

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 52R&D Systems
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Pathways related to Neonatal Stroke according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.3SERPINE1, F5
2
Hide members
9.3SERPINE1, F5
3
Hide members
8.8ALB, SERPINE1, F5
48.5MTHFR, SERPINE1, ALB

Compounds for genes affiliated with Neonatal Stroke

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience
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Compounds related to Neonatal Stroke according to GeneCards/GeneDecks:

(show top 50)    (show all 58)
idCompoundScoreTop Affiliating Genes
1aspartate4410.4ALB
2tacrolimus44 49 1112.3ALB
3heparin44 28 11 2413.1MTHFR
4mannitol44 1110.9AQP4, ALB
5acenocoumarol44 49 1111.8ALB, F5
6ceftriaxone44 1110.8F5, ALB
7batroxobin449.8SERPINE1, F5
8ancrod449.8SERPINE1, F5
9Drotrecogin alfa119.7F5, SERPINE1
10antipyrine44 1110.7ALB, F5
11fosinopril44 1110.7ALB, SERPINE1
12repaglinide44 49 1111.7ALB, SERPINE1
13ramipril44 1110.7SERPINE1, ALB
14valsartan44 59 28 1112.7ALB, SERPINE1
15perindopril44 49 1111.6SERPINE1, ALB
16irbesartan44 28 49 1112.6SERPINE1, ALB
17tibolone449.6SERPINE1, F5
18cyproteroneacetate449.6SERPINE1, F5
19hydrochlorothiazide44 49 28 11 2413.6ALB, SERPINE1
20Pyridoxine11 2410.5ALB, MTHFR
21candesartan44 28 1111.5ALB, SERPINE1
225-methyltetrahydrofolate44 1110.5F5, MTHFR
23cystathionine449.5MTHFR, F5
24enalapril44 49 1111.5SERPINE1, ALB
25amlodipine44 49 11 2412.4ALB, SERPINE1
26urea44 11 2411.4ALB, F5, AQP4
27fluorouracil49 1110.4MTHFR, ALB
28spironolactone49 44 59 28 1113.3ALB, SERPINE1
29desmopressin44 59 28 1112.3SERPINE1, F5
30mycophenolate mofetil44 49 1111.3F5, SERPINE1, ALB
31kininogen449.3SERPINE1, F5, ALB
32sodium dodecylsulfate449.2F5, SERPINE1, ALB
33diisopropylfluorophosphate449.2SERPINE1, ALB
34vitamin b6449.1MTHFR, F5, ALB
35vitamin b12449.0ALB, F5, MTHFR
36folate449.0ALB, MTHFR, F5
37metformin44 49 1110.9MTHFR, SERPINE1, F5
38cyclophosphamide44 49 1110.9MTHFR, SERPINE1, F5
39ascorbic acid44 249.9MTHFR, F5, ALB
40aspirin44 49 28 2411.8SERPINE1, MTHFR, F5
41methotrexate44 49 1110.8MTHFR, ALB, SERPINE1
42p00001448.7MTHFR, SERPINE1
43uric acid44 249.4SERPINE1, F5, MTHFR, ALB
44homocysteine44 249.4MTHFR, F5, ALB, SERPINE1
45fibrinogen448.4SERPINE1, ALB, MTHFR, F5
46creatinine448.4MTHFR, F5, SERPINE1, ALB
47testosterone44 59 11 2411.4MTHFR, F5, ALB, SERPINE1
48cholesterol44 28 11 2411.4ALB, MTHFR, F5, SERPINE1
49cysteine448.3AQP4, ALB, MTHFR, F5
50retinoic acid44 249.2MTHFR, SERPINE1, F5, AQP4

GO Terms for genes affiliated with Neonatal Stroke

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Sources:
16Gene Ontology
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Cellular components related to Neonatal Stroke according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.7ALB, SERPINE1, F5
2extracellular regionGO:0055768.4ALB, SERPINE1, F5, CTF1
3extracellular spaceGO:0056158.1CTF1, F5, SERPINE1, ALB

Biological processes related to Neonatal Stroke according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood circulationGO:0080158.8MTHFR, F5
2platelet degranulationGO:0025768.8ALB, SERPINE1, F5
3blood coagulationGO:0075968.8ALB, SERPINE1, F5
4platelet activationGO:0301688.7F5, SERPINE1, ALB

Molecular functions related to Neonatal Stroke according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.4ALB, F5

Products for genes affiliated with Neonatal Stroke

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neonatal Stroke

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet