MCID: NNT003
MIFTS: 26

Neonatal Thyrotoxicosis

Categories: Endocrine diseases

Aliases & Classifications for Neonatal Thyrotoxicosis

MalaCards integrated aliases for Neonatal Thyrotoxicosis:

Name: Neonatal Thyrotoxicosis 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12573
ICD10 33 P72.1
ICD9CM 35 775.3
NCIt 47 C114906
SNOMED-CT 64 13795004
UMLS 69 C0158983

Summaries for Neonatal Thyrotoxicosis

MalaCards based summary : Neonatal Thyrotoxicosis is related to isolated klippel-feil syndrome and corticosterone methyloxidase deficiency. An important gene associated with Neonatal Thyrotoxicosis is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Human Thyroid Stimulating Hormone (TSH) signaling pathway and Selenium Metabolism and Selenoproteins. Affiliated tissues include thyroid, heart and pituitary, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Neonatal Thyrotoxicosis

Diseases related to Neonatal Thyrotoxicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
id Related Disease Score Top Affiliating Genes
1 isolated klippel-feil syndrome 10.3 LHX3 PROP1
2 corticosterone methyloxidase deficiency 10.2 LHX3 PROP1
3 aminoacylase 1 deficiency 10.2 LHX3 PROP1
4 acute myeloid leukemia, susceptibility, gata2-related 10.2 LHX3 PROP1
5 primary hypomagnesemia 10.2 LHX3 PROP1
6 amelogenesis imperfecta, hypomaturation type, iia6 10.2 TSHR TXNRD2
7 molybdenum cofactor deficiency b 10.2 LHX3 PROP1
8 mental retardation, x-linked syndromic, christianson type 10.2 LHX3 PROP1
9 uterine ligament clear cell adenocarcinoma 10.1 LHX3 PROP1
10 thyroiditis 10.1
11 cloacogenic carcinoma 10.0 TSHR TXNRD2
12 nephrogenic systemic fibrosis 10.0 PAX8 TSHR
13 allergic asthma 10.0 LHX3 PROP1
14 panhypophysitis 10.0 PAX8 TSHR
15 hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 10.0 PAX8 TSHR
16 meningovascular neurosyphilis 9.9 PAX8 TSHR
17 bladder diffuse clear cell adenocarcinoma 9.8 PAX8 TSHR
18 hypothyroidism 9.8
19 hyperthyroidism 9.8
20 primary bacterial infectious disease 9.8 PAX8 TSHR
21 pulmonary hypertension 9.7
22 gastrointestinal system cancer 9.7 PAX8 TSHR
23 frontotemporal dementia and/or amyotrophic lateral sclerosis 4 9.7 PAX8 TSHR
24 graves' disease 9.6
25 infertility 9.6
26 hypertensive encephalopathy 9.6
27 hypoglycemia 9.6
28 encephalopathy 9.6
29 thyroid hormone resistance 9.6
30 congestive heart failure 9.6
31 craniosynostosis 9.6
32 chorea, hereditary benign 9.6 PAX8 TSHR
33 cholesterol embolism 9.5 DIO3 PAX8 TSHR
34 otosclerosis 9.4 PAX8 TSHR TXNRD2
35 non-distal trisomy 10q 9.4 PAX8 TSHR
36 fibrolamellar carcinoma 8.9 DIO3 PAX8 TSHR TXNRD2
37 potter's syndrome 7.5 DIO3 LCT LHX3 PAX8 PROP1 TSHR

Graphical network of the top 20 diseases related to Neonatal Thyrotoxicosis:



Diseases related to Neonatal Thyrotoxicosis

Symptoms & Phenotypes for Neonatal Thyrotoxicosis

MGI Mouse Phenotypes related to Neonatal Thyrotoxicosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.63 DIO3 LHX3 PAX8 PROP1 TSHR TXNRD2
2 mortality/aging MP:0010768 9.43 PROP1 TSHR TXNRD2 DIO3 LHX3 PAX8
3 reproductive system MP:0005389 9.02 DIO3 LHX3 PAX8 PROP1 TSHR

Drugs & Therapeutics for Neonatal Thyrotoxicosis

Search Clinical Trials , NIH Clinical Center for Neonatal Thyrotoxicosis

Genetic Tests for Neonatal Thyrotoxicosis

Anatomical Context for Neonatal Thyrotoxicosis

MalaCards organs/tissues related to Neonatal Thyrotoxicosis:

39
Thyroid, Heart, Pituitary, Testes

Publications for Neonatal Thyrotoxicosis

Articles related to Neonatal Thyrotoxicosis:

(show top 50) (show all 57)
id Title Authors Year
1
Fetal/neonatal Thyrotoxicosis in a Newborn From a Hypothyroid Woman With Hashimoto's Thyroiditis. ( 27813690 )
2016
2
Neonatal thyrotoxicosis caused by maternal autoimmune hyperthyroidism. ( 25750228 )
2015
3
Images in clinical medicine. Neonatal thyrotoxicosis. ( 24670170 )
2014
4
Neonatal thyrotoxicosis with severe supraventricular tachycardia: case report and review of the literature. ( 25153577 )
2014
5
Fetal and neonatal thyrotoxicosis. ( 24251220 )
2013
6
Neonatal thyrotoxicosis presenting as persistent pulmonary hypertension. ( 22669869 )
2012
7
Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. ( 18558604 )
2008
8
Neonatal thyrotoxicosis and persistent pulmonary hypertension necessitating extracorporeal life support. ( 15629961 )
2005
9
Neonatal thyrotoxicosis and conjugated hyperbilirubinemia. ( 12962270 )
2003
10
A case report of neonatal thyrotoxicosis due to maternal autoimmune hyperthyroidism. ( 14695499 )
2003
11
Neonatal thyrotoxicosis and maternal infertility in thyroid hormone resistance due to a mutation in the TRbeta gene (M313T). ( 12201835 )
2002
12
The relationship between maternal serum thyroid-stimulating immunoglobulin and fetal and neonatal thyrotoxicosis. ( 12052596 )
2002
13
Congenital neonatal thyrotoxicosis and previous maternal radioiodine therapy. ( 10797041 )
2000
14
Hypertensive encephalopathy in a patient with neonatal thyrotoxicosis. ( 10486076 )
1999
15
Congenital chylothorax in neonatal thyrotoxicosis. ( 10685206 )
1999
16
Thyrotropin receptor antibodies associated with post-operative relapse of thyrotoxicosis in a pregnancy complicated by neonatal thyrotoxicosis. ( 2315685 )
1990
17
Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis. ( 2874029 )
1986
18
Diminished thyroid-stimulating hormone secretion associated with neonatal thyrotoxicosis. ( 3093659 )
1986
19
Neonatal thyrotoxicosis treated with exchange transfusion and Lugol's iodine. ( 2859196 )
1985
20
Effects of L-thyroxine treatment on pituitary GH content of adult rats with neonatal thyrotoxicosis. ( 6637335 )
1983
21
Hypertension in neonatal thyrotoxicosis. ( 7069539 )
1982
22
Neonatal thyrotoxicosis: a rare pediatric emergency. ( 6893645 )
1980
23
Complications of propranolol use in neonatal thyrotoxicosis. ( 7395835 )
1980
24
Is propranolol alone really beneficial in neonatal thyrotoxicosis? Bradycardia and hypoglycemia evoke the doctrine of primum non nocere. ( 6998280 )
1980
25
Neonatal thyrotoxicosis: intellectual impairment and craniosynostosis in later years. ( 7400892 )
1980
26
Oxygen consumption in the rat following neonatal thyrotoxicosis. ( 488304 )
1979
27
The role of thyroid stimulating immunoglobulins of Graves's disease in neonatal thyrotoxicosis. ( 581471 )
1978
28
Neonatal thyrotoxicosis in four siblings born to a previously thyrotoxic mother. ( 717342 )
1978
29
Neonatal thyrotoxicosis: alterations in serum concentrations of LATS-protector, T4, T3, reverse T3, and 3,3'T2. ( 650321 )
1978
30
Neonatal thyrotoxicosis following maternal hypothyroidism. ( 619059 )
1978
31
Neonatal thyrotoxicosis with long acting thyroid stimulator-protector. ( 576864 )
1977
32
Neonatal thyrotoxicosis. ( 899782 )
1977
33
Neonatal thyrotoxicosis. ( 909013 )
1977
34
The possible relation between postpartum exacerbation of hyperthyroidism and neonatal thyrotoxicosis. ( 596245 )
1977
35
The behaviour of thyroid hormones in an infant with untreated neonatal thyrotoxicosis. ( 908154 )
1977
36
Neonatal thyrotoxicosis associated with the hyperviscosity syndrome. ( 830919 )
1977
37
Humoral and genetic factors in thyrotoxic Graves disease and neonatal thyrotoxicosis. ( 946443 )
1976
38
Attempted prevention of neonatal thyrotoxicosis. ( 990790 )
1976
39
Attempted prevention of neonatal thyrotoxicosis. ( 1000245 )
1976
40
Neonatal thyrotoxicosis is associated with transplacental passage of human thyroid stimulating immunoglobulin (HTSI). ( 962368 )
1976
41
Congestive heart failure in neonatal thyrotoxicosis. A curable casue of heart failure in the newborn. ( 1192685 )
1975
42
Neonatal thyrotoxicosis. ( 1134079 )
1975
43
Neonatal thyrotoxicosis treated with propranolol. ( 4429365 )
1974
44
Persistent abnormalities in pituitary function following neonatal thyrotoxicosis in the rat. ( 4208653 )
1974
45
Neonatal thyrotoxicosis. ( 4800423 )
1973
46
Propranolol in treatment of neonatal thyrotoxicosis. ( 4757519 )
1973
47
The role of long acting thyroid stimulator in neonatal thyrotoxicosis. ( 4677121 )
1972
48
Skeletal changes in neonatal thyrotoxicosis. ( 5008137 )
1972
49
Neonatal thyrotoxicosis. ( 4185737 )
1969
50
Neonatal thyrotoxicosis. Elevated long-acting thyroid stimulator (LATS) in mother and infant. ( 5762465 )
1969

Variations for Neonatal Thyrotoxicosis

Expression for Neonatal Thyrotoxicosis

Search GEO for disease gene expression data for Neonatal Thyrotoxicosis.

Pathways for Neonatal Thyrotoxicosis

Pathways related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.79 PAX8 TSHR
2 10.29 DIO3 TXNRD2

GO Terms for Neonatal Thyrotoxicosis

Biological processes related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription from RNA polymerase II promoter GO:0006366 9.5 LHX3 PAX8 PROP1
2 central nervous system development GO:0007417 9.37 PAX8 PROP1
3 animal organ morphogenesis GO:0009887 9.26 LHX3 PROP1
4 dorsal/ventral pattern formation GO:0009953 9.16 LHX3 PROP1
5 positive regulation of multicellular organism growth GO:0040018 8.96 DIO3 TSHR
6 thyroid-stimulating hormone signaling pathway GO:0038194 8.62 PAX8 TSHR

Molecular functions related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.13 LHX3 PAX8 PROP1
2 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Neonatal Thyrotoxicosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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