MCID: NNT003
MIFTS: 28

Neonatal Thyrotoxicosis malady

Endocrine diseases category

Aliases & Classifications for Neonatal Thyrotoxicosis

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Aliases & Descriptions for Neonatal Thyrotoxicosis:

Name: Neonatal Thyrotoxicosis 10 47 12 65


Classifications:



External Ids:

Disease Ontology10 DOID:12573
SNOMED-CT59 13795004
ICD9CM29 775.3

Summaries for Neonatal Thyrotoxicosis

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MalaCards based summary: Neonatal Thyrotoxicosis is related to thyroid hormone resistance and thyroiditis. An important gene associated with Neonatal Thyrotoxicosis is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways are Selenium Pathway and Selenium Metabolism and Selenoproteins. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are reproductive system and endocrine/exocrine gland.

Related Diseases for Neonatal Thyrotoxicosis

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Diseases related to Neonatal Thyrotoxicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
idRelated DiseaseScoreTop Affiliating Genes
1thyroid hormone resistance30.0TRH, TXNRD2
2thyroiditis10.6
3hyperthyroidism10.3
4pulmonary hypertension10.2
5hypothyroidism10.2
6inherited predisposition to essential thrombocythemia10.2LHX3, PROP1
7septooptic dysplasia10.1LHX3, PROP1
8complete lcat deficiency10.1LHX3, PROP1
9pituitary hormone deficiency, combined, 210.1LHX3, PROP1
10pituitary adenoma, growth hormone-secreting 210.1LHX3, PROP1
11pituitary infarct10.1LHX3, PROP1
12neonatal meningitis10.1PAX8, TSHR
13iatrogenic or traumatic pituitary deficiency10.1PAX8, TSHR
14hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.1PAX8, TSHR
15congestive heart failure10.1
16craniosynostosis10.1
17graves' disease10.1
18hypertensive encephalopathy10.1
19hypoglycemia10.1
20infertility10.1
21encephalopathy10.1
22hypopyon10.1LHX3, PROP1
23eumycotic mycetoma10.1PAX8, TSHR
24food allergy10.0PAX8, TSHR
25congenital epulis10.0TRH, TSHR
26familial abdominal aortic aneurysm10.0PAX8, TSHR
27hypophosphatemia10.0PAX8, TSHR
28central nervous system primitive neuroectodermal neoplasm10.0PROP1, TRH
29generalized torsion dystonia10.0TRH, TXNRD2
30tibial neuropathy9.9TRH, TSHR
31thyroid cancer, nonmedullary, 29.9PAX8, TSHR
32cutaneous mastocytosis9.9PROP1, TRH
33hypertrichosis9.9TRH, TSHR
34endocrine organ benign neoplasm9.8PAX8, TSHR
35acute myeloid leukemia, flt3-related9.8LHX3, PROP1, TRH
36hypertelorism, preauricular sinus, punctal pits, and deafness9.8TRH, TSHR, TXNRD2
37hypotrichosis9.8PAX8, TRH, TSHR
38gonadal disease9.6PAX8, TRH, TSHR, TXNRD2
39thyroid sarcoma9.6PAX8, TRH, TSHR, TXNRD2
40appendiceal neoplasm8.9DIO3, LCT, LHX3, PAX8, PROP1, TRH

Graphical network of the top 20 diseases related to Neonatal Thyrotoxicosis:



Diseases related to neonatal thyrotoxicosis

Symptoms for Neonatal Thyrotoxicosis

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Drugs & Therapeutics for Neonatal Thyrotoxicosis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Neonatal Thyrotoxicosis

Genetic Tests for Neonatal Thyrotoxicosis

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Anatomical Context for Neonatal Thyrotoxicosis

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MalaCards organs/tissues related to Neonatal Thyrotoxicosis:

33
Thyroid, Heart, Pituitary, Testes

Animal Models for Neonatal Thyrotoxicosis or affiliated genes

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MGI Mouse Phenotypes related to Neonatal Thyrotoxicosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.9DIO3, LHX3, PAX8, PROP1, TSHR
2MP:00053797.9LHX3, PAX8, PROP1, TRH, TSHR
3MP:00053787.5DIO3, LHX3, PAX8, PROP1, TRH, TSHR
4MP:00036317.3LHX3, PAX8, PROP1, TRH, TSHR, TXNRD2
5MP:00053766.7DIO3, LHX3, PAX8, PROP1, TRH, TSHR

Publications for Neonatal Thyrotoxicosis

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Articles related to Neonatal Thyrotoxicosis:

(show top 50)    (show all 56)
idTitleAuthorsYear
1
Neonatal thyrotoxicosis caused by maternal autoimmune hyperthyroidism. (25750228)
2015
2
Images in clinical medicine. Neonatal thyrotoxicosis. (24670170)
2014
3
Neonatal thyrotoxicosis with severe supraventricular tachycardia: case report and review of the literature. (25153577)
2014
4
Fetal and neonatal thyrotoxicosis. (24251220)
2013
5
Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. (18558604)
2008
6
Neonatal thyrotoxicosis and persistent pulmonary hypertension necessitating extracorporeal life support. (15629961)
2005
7
A case report of neonatal thyrotoxicosis due to maternal autoimmune hyperthyroidism. (14695499)
2003
8
Neonatal thyrotoxicosis and maternal infertility in thyroid hormone resistance due to a mutation in the TRbeta gene (M313T). (12201835)
2002
9
The relationship between maternal serum thyroid-stimulating immunoglobulin and fetal and neonatal thyrotoxicosis. (12052596)
2002
10
Congenital neonatal thyrotoxicosis and previous maternal radioiodine therapy. (10797041)
2000
11
Hypertensive encephalopathy in a patient with neonatal thyrotoxicosis. (10486076)
1999
12
Congenital chylothorax in neonatal thyrotoxicosis. (10685206)
1999
13
Thyrotropin receptor antibodies associated with post-operative relapse of thyrotoxicosis in a pregnancy complicated by neonatal thyrotoxicosis. (2315685)
1990
14
Diminished thyroid-stimulating hormone secretion associated with neonatal thyrotoxicosis. (3093659)
1986
15
Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis. (2874029)
1986
16
Neonatal thyrotoxicosis treated with exchange transfusion and Lugol's iodine. (2859196)
1985
17
Effects of L-thyroxine treatment on pituitary GH content of adult rats with neonatal thyrotoxicosis. (6637335)
1983
18
Complications of propranolol use in neonatal thyrotoxicosis. (7395835)
1980
19
Is propranolol alone really beneficial in neonatal thyrotoxicosis? Bradycardia and hypoglycemia evoke the doctrine of primum non nocere. (6998280)
1980
20
Neonatal thyrotoxicosis: a rare pediatric emergency. (6893645)
1980
21
Neonatal thyrotoxicosis: intellectual impairment and craniosynostosis in later years. (7400892)
1980
22
Oxygen consumption in the rat following neonatal thyrotoxicosis. (488304)
1979
23
Neonatal thyrotoxicosis in four siblings born to a previously thyrotoxic mother. (717342)
1978
24
The role of thyroid stimulating immunoglobulins of Graves's disease in neonatal thyrotoxicosis. (581471)
1978
25
Neonatal thyrotoxicosis: alterations in serum concentrations of LATS-protector, T4, T3, reverse T3, and 3,3'T2. (650321)
1978
26
Neonatal thyrotoxicosis following maternal hypothyroidism. (619059)
1978
27
The behaviour of thyroid hormones in an infant with untreated neonatal thyrotoxicosis. (908154)
1977
28
Neonatal thyrotoxicosis. (899782)
1977
29
Neonatal thyrotoxicosis. (909013)
1977
30
The possible relation between postpartum exacerbation of hyperthyroidism and neonatal thyrotoxicosis. (596245)
1977
31
Neonatal thyrotoxicosis with long acting thyroid stimulator-protector. (576864)
1977
32
Neonatal thyrotoxicosis is associated with transplacental passage of human thyroid stimulating immunoglobulin (HTSI). (962368)
1976
33
Humoral and genetic factors in thyrotoxic Graves disease and neonatal thyrotoxicosis. (946443)
1976
34
Attempted prevention of neonatal thyrotoxicosis. (990790)
1976
35
Attempted prevention of neonatal thyrotoxicosis. (1000245)
1976
36
Congestive heart failure in neonatal thyrotoxicosis. A curable casue of heart failure in the newborn. (1192685)
1975
37
Persistent abnormalities in pituitary function following neonatal thyrotoxicosis in the rat. (4208653)
1974
38
Neonatal thyrotoxicosis treated with propranolol. (4429365)
1974
39
Propranolol in treatment of neonatal thyrotoxicosis. (4757519)
1973
40
Neonatal thyrotoxicosis. (4800423)
1973
41
The role of long acting thyroid stimulator in neonatal thyrotoxicosis. (4677121)
1972
42
Skeletal changes in neonatal thyrotoxicosis. (5008137)
1972
43
Neonatal thyrotoxicosis. Elevated long-acting thyroid stimulator (LATS) in mother and infant. (5762465)
1969
44
Neonatal thyrotoxicosis. (4185737)
1969
45
Neonatal thyrotoxicosis. (5645973)
1968
46
A case of neonatal thyrotoxicosis. (5588736)
1967
47
Neonatal thyrotoxicosis associated with maternal hypothyroidism. (4159675)
1966
48
Neonatal thyrotoxicosis: report of three cases involving four infants. (4168753)
1966
49
Survival time of circulating long-acting thyroid stimulator in neonatal thyrotoxicosis: implications for diagnosis and therapy of the disorder. (5846829)
1965
50
Neonatal thyrotoxicosis. (13731873)
1960

Variations for Neonatal Thyrotoxicosis

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Expression for genes affiliated with Neonatal Thyrotoxicosis

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Search GEO for disease gene expression data for Neonatal Thyrotoxicosis.

Pathways for genes affiliated with Neonatal Thyrotoxicosis

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Pathways related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4DIO3, TXNRD2
29.4DIO3, TXNRD2
39.3TRH, TSHR

GO Terms for genes affiliated with Neonatal Thyrotoxicosis

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Biological processes related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid-stimulating hormone signaling pathwayGO:003819410.0PAX8, TSHR
2positive regulation of multicellular organism growthGO:00400189.6DIO3, TSHR
3hormone-mediated signaling pathwayGO:00097559.4TRH, TSHR
4response to ethanolGO:00454719.2LCT, TRH

Molecular functions related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid-stimulating hormone receptor activityGO:00049969.5PAX8, TSHR

Sources for Neonatal Thyrotoxicosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet