MCID: NNT003
MIFTS: 27

Neonatal Thyrotoxicosis malady

Category: Endocrine diseases

Aliases & Classifications for Neonatal Thyrotoxicosis

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Summaries for Neonatal Thyrotoxicosis

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MalaCards based summary: Neonatal Thyrotoxicosis is related to shaver's disease and idiopathic hypersomnia without long sleep time. An important gene associated with Neonatal Thyrotoxicosis is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways are Selenium Metabolism and Selenoproteins and Human Thyroid Stimulating Hormone (TSH) signaling pathway. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Related Diseases for Neonatal Thyrotoxicosis

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Diseases related to Neonatal Thyrotoxicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
idRelated DiseaseScoreTop Affiliating Genes
1shaver's disease10.1LHX3, PROP1
2idiopathic hypersomnia without long sleep time10.1LHX3, PROP1
3thyroiditis10.1
4early-onset glaucoma10.1LHX3, PROP1
5aminoacylase 1 deficiency10.1LHX3, PROP1
6ossification of the posterior longitudinal ligament of spine10.1LHX3, PROP1
7adult i blood group with or without congenital cataract10.1LHX3, PROP1
8hypothyroidism, congenital, nongoitrous, 110.1TSHR, TXNRD2
9mucopolysaccharidosis type vi10.1LHX3, PROP1
10urethra clear cell adenocarcinoma10.1LHX3, PROP1
11neuhauser daly magnelli syndrome10.0PAX8, TSHR
12mesocardia10.0PAX8, TSHR
13neuronopathy, distal hereditary motor, type viia10.0PAX8, TSHR
14exanthema subitum10.0PAX8, TSHR
15autoimmune hemolytic anemia10.0TSHR, TXNRD2
16cervix squamous papilloma10.0LHX3, PROP1
17peritoneal serous papillary adenocarcinoma9.9PAX8, TSHR
18commensal bacterial infectious disease9.9PAX8, TSHR
19tenosynovitis of foot and ankle9.9PAX8, TSHR
20hypothyroidism9.8
21hyperthyroidism9.8
22otosclerosis9.8PAX8, TSHR, TXNRD2
23choreoathetosis, hypothyroidism, and neonatal respiratory distress9.8PAX8, TSHR
24pulmonary hypertension9.7
25cholesterol embolism9.6DIO3, PAX8, PROP1, TSHR
26aflatoxins-related hepatocellular carcinoma9.6DIO3, PAX8, TSHR, TXNRD2
27thyroid hormone resistance9.6
28congestive heart failure9.6
29craniosynostosis9.6
30graves' disease9.6
31infertility9.6
32hypertensive encephalopathy9.6
33hypoglycemia9.6
34encephalopathy9.6
35potter's syndrome9.0DIO3, LCT, LHX3, PAX8, PROP1, TSHR

Graphical network of the top 20 diseases related to Neonatal Thyrotoxicosis:



Diseases related to neonatal thyrotoxicosis

Symptoms & Phenotypes for Neonatal Thyrotoxicosis

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MGI Mouse Phenotypes related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.0DIO3, LHX3, PAX8, PROP1, TSHR, TXNRD2
2MP:00107687.9DIO3, LHX3, PAX8, PROP1, TSHR, TXNRD2
3MP:00053897.8DIO3, LHX3, PAX8, PROP1, TSHR

Drugs & Therapeutics for Neonatal Thyrotoxicosis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Neonatal Thyrotoxicosis

Genetic Tests for Neonatal Thyrotoxicosis

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Anatomical Context for Neonatal Thyrotoxicosis

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MalaCards organs/tissues related to Neonatal Thyrotoxicosis:

36
Thyroid, Heart, Pituitary, Testes

Publications for Neonatal Thyrotoxicosis

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Articles related to Neonatal Thyrotoxicosis:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Fetal/neonatal Thyrotoxicosis in a Newborn From a Hypothyroid Woman With Hashimoto's Thyroiditis. (27813690)
2016
2
Neonatal thyrotoxicosis caused by maternal autoimmune hyperthyroidism. (25750228)
2015
3
Neonatal thyrotoxicosis with severe supraventricular tachycardia: case report and review of the literature. (25153577)
2014
4
Images in clinical medicine. Neonatal thyrotoxicosis. (24670170)
2014
5
Fetal and neonatal thyrotoxicosis. (24251220)
2013
6
Neonatal thyrotoxicosis presenting as persistent pulmonary hypertension. (22669869)
2012
7
Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. (18558604)
2008
8
Neonatal thyrotoxicosis and persistent pulmonary hypertension necessitating extracorporeal life support. (15629961)
2005
9
A case report of neonatal thyrotoxicosis due to maternal autoimmune hyperthyroidism. (14695499)
2003
10
Neonatal thyrotoxicosis and conjugated hyperbilirubinemia. (12962270)
2003
11
Neonatal thyrotoxicosis and maternal infertility in thyroid hormone resistance due to a mutation in the TRbeta gene (M313T). (12201835)
2002
12
The relationship between maternal serum thyroid-stimulating immunoglobulin and fetal and neonatal thyrotoxicosis. (12052596)
2002
13
Congenital neonatal thyrotoxicosis and previous maternal radioiodine therapy. (10797041)
2000
14
Hypertensive encephalopathy in a patient with neonatal thyrotoxicosis. (10486076)
1999
15
Congenital chylothorax in neonatal thyrotoxicosis. (10685206)
1999
16
Thyrotropin receptor antibodies associated with post-operative relapse of thyrotoxicosis in a pregnancy complicated by neonatal thyrotoxicosis. (2315685)
1990
17
Diminished thyroid-stimulating hormone secretion associated with neonatal thyrotoxicosis. (3093659)
1986
18
Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis. (2874029)
1986
19
Neonatal thyrotoxicosis treated with exchange transfusion and Lugol's iodine. (2859196)
1985
20
Effects of L-thyroxine treatment on pituitary GH content of adult rats with neonatal thyrotoxicosis. (6637335)
1983
21
Hypertension in neonatal thyrotoxicosis. (7069539)
1982
22
Neonatal thyrotoxicosis: a rare pediatric emergency. (6893645)
1980
23
Complications of propranolol use in neonatal thyrotoxicosis. (7395835)
1980
24
Neonatal thyrotoxicosis: intellectual impairment and craniosynostosis in later years. (7400892)
1980
25
Is propranolol alone really beneficial in neonatal thyrotoxicosis? Bradycardia and hypoglycemia evoke the doctrine of primum non nocere. (6998280)
1980
26
Oxygen consumption in the rat following neonatal thyrotoxicosis. (488304)
1979
27
Neonatal thyrotoxicosis: alterations in serum concentrations of LATS-protector, T4, T3, reverse T3, and 3,3'T2. (650321)
1978
28
Neonatal thyrotoxicosis following maternal hypothyroidism. (619059)
1978
29
The role of thyroid stimulating immunoglobulins of Graves's disease in neonatal thyrotoxicosis. (581471)
1978
30
Neonatal thyrotoxicosis in four siblings born to a previously thyrotoxic mother. (717342)
1978
31
The possible relation between postpartum exacerbation of hyperthyroidism and neonatal thyrotoxicosis. (596245)
1977
32
Neonatal thyrotoxicosis. (899782)
1977
33
Neonatal thyrotoxicosis associated with the hyperviscosity syndrome. (830919)
1977
34
Neonatal thyrotoxicosis. (909013)
1977
35
Neonatal thyrotoxicosis with long acting thyroid stimulator-protector. (576864)
1977
36
The behaviour of thyroid hormones in an infant with untreated neonatal thyrotoxicosis. (908154)
1977
37
Attempted prevention of neonatal thyrotoxicosis. (1000245)
1976
38
Attempted prevention of neonatal thyrotoxicosis. (990790)
1976
39
Humoral and genetic factors in thyrotoxic Graves disease and neonatal thyrotoxicosis. (946443)
1976
40
Neonatal thyrotoxicosis is associated with transplacental passage of human thyroid stimulating immunoglobulin (HTSI). (962368)
1976
41
Congestive heart failure in neonatal thyrotoxicosis. A curable casue of heart failure in the newborn. (1192685)
1975
42
Neonatal thyrotoxicosis. (1134079)
1975
43
Persistent abnormalities in pituitary function following neonatal thyrotoxicosis in the rat. (4208653)
1974
44
Neonatal thyrotoxicosis treated with propranolol. (4429365)
1974
45
Propranolol in treatment of neonatal thyrotoxicosis. (4757519)
1973
46
Neonatal thyrotoxicosis. (4800423)
1973
47
The role of long acting thyroid stimulator in neonatal thyrotoxicosis. (4677121)
1972
48
Skeletal changes in neonatal thyrotoxicosis. (5008137)
1972
49
Neonatal thyrotoxicosis. Elevated long-acting thyroid stimulator (LATS) in mother and infant. (5762465)
1969
50
Neonatal thyrotoxicosis. (4185737)
1969

Variations for Neonatal Thyrotoxicosis

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Expression for genes affiliated with Neonatal Thyrotoxicosis

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Search GEO for disease gene expression data for Neonatal Thyrotoxicosis.

Pathways for genes affiliated with Neonatal Thyrotoxicosis

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Pathways related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3DIO3, TXNRD2
29.3PAX8, TSHR

GO Terms for genes affiliated with Neonatal Thyrotoxicosis

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Biological processes related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of multicellular organism growthGO:004001810.2DIO3, TSHR
2animal organ morphogenesisGO:000988710.2LHX3, PROP1
3dorsal/ventral pattern formationGO:000995310.2LHX3, PROP1
4thyroid-stimulating hormone signaling pathwayGO:00381949.9PAX8, TSHR
5central nervous system developmentGO:00074179.8PAX8, PROP1
6transcription from RNA polymerase II promoterGO:00063668.7LHX3, PAX8, PROP1

Molecular functions related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1thyroid-stimulating hormone receptor activityGO:00049969.3PAX8, TSHR
2sequence-specific DNA bindingGO:00435658.6LHX3, PAX8, PROP1

Sources for Neonatal Thyrotoxicosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet