MCID: NNT003
MIFTS: 28

Neonatal Thyrotoxicosis

Categories: Endocrine diseases

Aliases & Classifications for Neonatal Thyrotoxicosis

MalaCards integrated aliases for Neonatal Thyrotoxicosis:

Name: Neonatal Thyrotoxicosis 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12573
ICD10 32 P72.1
ICD9CM 34 775.3
NCIt 46 C114906
SNOMED-CT 64 13795004
UMLS 69 C0158983

Summaries for Neonatal Thyrotoxicosis

MalaCards based summary : Neonatal Thyrotoxicosis is related to graves disease 1 and thyroiditis. An important gene associated with Neonatal Thyrotoxicosis is TSHR (Thyroid Stimulating Hormone Receptor), and among its related pathways/superpathways are Human Thyroid Stimulating Hormone (TSH) signaling pathway and Selenium Metabolism and Selenoproteins. Affiliated tissues include thyroid, heart and pituitary, and related phenotypes are homeostasis/metabolism and mortality/aging

Related Diseases for Neonatal Thyrotoxicosis

Diseases related to Neonatal Thyrotoxicosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 graves disease 1 30.9 TSHR TXNRD2
2 thyroiditis 30.2 TSHR TXNRD2
3 hypothyroidism 29.2 DIO3 PAX8 TSHR
4 hypothyroidism due to deficient transcription factors involved in pituitary development or function 10.2 LHX3 PROP1
5 combined pituitary hormone deficiency 10.1 LHX3 PROP1
6 septooptic dysplasia 10.1 LHX3 PROP1
7 isolated growth hormone deficiency 10.1 LHX3 PROP1
8 pituitary hormone deficiency, combined, 2 10.1 LHX3 PROP1
9 borjeson-forssman-lehmann syndrome 10.1 LHX3 PROP1
10 pituitary gland disease 10.1 LHX3 PROP1
11 neonatal hypothyroidism 10.0 PAX8 TSHR
12 athyreosis 9.9 PAX8 TSHR
13 hypopituitarism 9.9 LHX3 PROP1
14 hypothyroidism, congenital, nongoitrous, 2 9.9 PAX8 TSHR
15 hyperthyroidism 9.9
16 multinodular goiter 9.8 PAX8 TSHR
17 follicular adenoma 9.8 PAX8 TSHR
18 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
19 pulmonary hypertension 9.8
20 congenital hypothyroidism 9.8 PAX8 TSHR
21 papillary carcinoma 9.7 PAX8 TSHR
22 chylothorax, congenital 9.6
23 congestive heart failure 9.6
24 craniosynostosis 9.6
25 graves' disease 9.6
26 bilirubin metabolic disorder 9.6
27 infertility 9.6
28 hypertensive encephalopathy 9.6
29 hypoglycemia 9.6
30 encephalopathy 9.6
31 differentiated thyroid carcinoma 9.6 PAX8 TSHR
32 thyroid cancer, nonmedullary, 1 9.6 DIO3 PAX8 TSHR
33 goiter 9.5 PAX8 TSHR TXNRD2
34 thyroid cancer, nonmedullary, 2 9.5 PAX8 TSHR
35 thyroid cancer 9.4 PAX8 TSHR TXNRD2
36 thyroid gland disease 9.1 DIO3 PAX8 TSHR TXNRD2

Graphical network of the top 20 diseases related to Neonatal Thyrotoxicosis:



Diseases related to Neonatal Thyrotoxicosis

Symptoms & Phenotypes for Neonatal Thyrotoxicosis

MGI Mouse Phenotypes related to Neonatal Thyrotoxicosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.63 DIO3 LHX3 PAX8 PROP1 TSHR TXNRD2
2 mortality/aging MP:0010768 9.43 DIO3 LHX3 PAX8 PROP1 TSHR TXNRD2
3 reproductive system MP:0005389 9.02 PROP1 TSHR DIO3 LHX3 PAX8

Drugs & Therapeutics for Neonatal Thyrotoxicosis

Search Clinical Trials , NIH Clinical Center for Neonatal Thyrotoxicosis

Genetic Tests for Neonatal Thyrotoxicosis

Anatomical Context for Neonatal Thyrotoxicosis

MalaCards organs/tissues related to Neonatal Thyrotoxicosis:

38
Thyroid, Heart, Pituitary, Testes

Publications for Neonatal Thyrotoxicosis

Articles related to Neonatal Thyrotoxicosis:

(show top 50) (show all 59)
# Title Authors Year
1
Neonatal Thyrotoxicosis. ( 29406005 )
2018
2
Maternal Thyrotropin Receptor Antibody Concentration and the Risk of Fetal and Neonatal Thyrotoxicosis: A Systematic Review. ( 29325496 )
2018
3
Fetal/neonatal Thyrotoxicosis in a Newborn From a Hypothyroid Woman With Hashimoto's Thyroiditis. ( 27813690 )
2016
4
Neonatal thyrotoxicosis caused by maternal autoimmune hyperthyroidism. ( 25750228 )
2015
5
Images in clinical medicine. Neonatal thyrotoxicosis. ( 24670170 )
2014
6
Neonatal thyrotoxicosis with severe supraventricular tachycardia: case report and review of the literature. ( 25153577 )
2014
7
Fetal and neonatal thyrotoxicosis. ( 24251220 )
2013
8
Neonatal thyrotoxicosis presenting as persistent pulmonary hypertension. ( 22669869 )
2012
9
Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. ( 18558604 )
2008
10
Neonatal thyrotoxicosis and persistent pulmonary hypertension necessitating extracorporeal life support. ( 15629961 )
2005
11
A case report of neonatal thyrotoxicosis due to maternal autoimmune hyperthyroidism. ( 14695499 )
2003
12
Neonatal thyrotoxicosis and conjugated hyperbilirubinemia. ( 12962270 )
2003
13
The relationship between maternal serum thyroid-stimulating immunoglobulin and fetal and neonatal thyrotoxicosis. ( 12052596 )
2002
14
Neonatal thyrotoxicosis and maternal infertility in thyroid hormone resistance due to a mutation in the TRbeta gene (M313T). ( 12201835 )
2002
15
Congenital neonatal thyrotoxicosis and previous maternal radioiodine therapy. ( 10797041 )
2000
16
Congenital chylothorax in neonatal thyrotoxicosis. ( 10685206 )
1999
17
Hypertensive encephalopathy in a patient with neonatal thyrotoxicosis. ( 10486076 )
1999
18
Thyrotropin receptor antibodies associated with post-operative relapse of thyrotoxicosis in a pregnancy complicated by neonatal thyrotoxicosis. ( 2315685 )
1990
19
Diminished thyroid-stimulating hormone secretion associated with neonatal thyrotoxicosis. ( 3093659 )
1986
20
Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis. ( 2874029 )
1986
21
Neonatal thyrotoxicosis treated with exchange transfusion and Lugol's iodine. ( 2859196 )
1985
22
Effects of L-thyroxine treatment on pituitary GH content of adult rats with neonatal thyrotoxicosis. ( 6637335 )
1983
23
Hypertension in neonatal thyrotoxicosis. ( 7069539 )
1982
24
Neonatal thyrotoxicosis: intellectual impairment and craniosynostosis in later years. ( 7400892 )
1980
25
Complications of propranolol use in neonatal thyrotoxicosis. ( 7395835 )
1980
26
Is propranolol alone really beneficial in neonatal thyrotoxicosis? Bradycardia and hypoglycemia evoke the doctrine of primum non nocere. ( 6998280 )
1980
27
Neonatal thyrotoxicosis: a rare pediatric emergency. ( 6893645 )
1980
28
Oxygen consumption in the rat following neonatal thyrotoxicosis. ( 488304 )
1979
29
Neonatal thyrotoxicosis in four siblings born to a previously thyrotoxic mother. ( 717342 )
1978
30
Neonatal thyrotoxicosis following maternal hypothyroidism. ( 619059 )
1978
31
The role of thyroid stimulating immunoglobulins of Graves's disease in neonatal thyrotoxicosis. ( 581471 )
1978
32
Neonatal thyrotoxicosis: alterations in serum concentrations of LATS-protector, T4, T3, reverse T3, and 3,3'T2. ( 650321 )
1978
33
Neonatal thyrotoxicosis. ( 899782 )
1977
34
Neonatal thyrotoxicosis with long acting thyroid stimulator-protector. ( 576864 )
1977
35
The behaviour of thyroid hormones in an infant with untreated neonatal thyrotoxicosis. ( 908154 )
1977
36
The possible relation between postpartum exacerbation of hyperthyroidism and neonatal thyrotoxicosis. ( 596245 )
1977
37
Neonatal thyrotoxicosis associated with the hyperviscosity syndrome. ( 830919 )
1977
38
Neonatal thyrotoxicosis. ( 909013 )
1977
39
Attempted prevention of neonatal thyrotoxicosis. ( 1000245 )
1976
40
Neonatal thyrotoxicosis is associated with transplacental passage of human thyroid stimulating immunoglobulin (HTSI). ( 962368 )
1976
41
Humoral and genetic factors in thyrotoxic Graves disease and neonatal thyrotoxicosis. ( 946443 )
1976
42
Attempted prevention of neonatal thyrotoxicosis. ( 990790 )
1976
43
Neonatal thyrotoxicosis. ( 1134079 )
1975
44
Congestive heart failure in neonatal thyrotoxicosis. A curable casue of heart failure in the newborn. ( 1192685 )
1975
45
Persistent abnormalities in pituitary function following neonatal thyrotoxicosis in the rat. ( 4208653 )
1974
46
Neonatal thyrotoxicosis treated with propranolol. ( 4429365 )
1974
47
Neonatal thyrotoxicosis. ( 4800423 )
1973
48
Propranolol in treatment of neonatal thyrotoxicosis. ( 4757519 )
1973
49
The role of long acting thyroid stimulator in neonatal thyrotoxicosis. ( 4677121 )
1972
50
Skeletal changes in neonatal thyrotoxicosis. ( 5008137 )
1972

Variations for Neonatal Thyrotoxicosis

Expression for Neonatal Thyrotoxicosis

Search GEO for disease gene expression data for Neonatal Thyrotoxicosis.

Pathways for Neonatal Thyrotoxicosis

Pathways related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 PAX8 TSHR
2 10.29 DIO3 TXNRD2

GO Terms for Neonatal Thyrotoxicosis

Biological processes related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription by RNA polymerase II GO:0006366 9.54 LHX3 PAX8 PROP1
2 central nervous system development GO:0007417 9.32 PAX8 PROP1
3 animal organ morphogenesis GO:0009887 9.26 LHX3 PROP1
4 dorsal/ventral pattern formation GO:0009953 9.16 LHX3 PROP1
5 positive regulation of multicellular organism growth GO:0040018 8.96 DIO3 TSHR
6 thyroid-stimulating hormone signaling pathway GO:0038194 8.62 PAX8 TSHR

Molecular functions related to Neonatal Thyrotoxicosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.13 LHX3 PAX8 PROP1
2 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Neonatal Thyrotoxicosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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