MCID: NNT003
MIFTS: 31

Neonatal Thyrotoxicosis malady

Endocrine diseases category

Summaries for Neonatal Thyrotoxicosis

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34MalaCards
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MalaCards: Neonatal Thyrotoxicosis is related to thyrotoxicosis and hyperthyroidism. An important gene associated with Neonatal Thyrotoxicosis is TSHR (thyroid stimulating hormone receptor). The compounds triiodothyronine and asparagine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and pituitary, and related mouse phenotypes are hearing/vestibular/ear and nervous system.

Aliases & Classifications for Neonatal Thyrotoxicosis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 28ICD9CM, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

neonatal thyrotoxicosis 9 11 46 63


External Ids:

Disease Ontology9 DOID:12573
SNOMED-CT59 13795004
ICD9CM28 775.3

Related Diseases for Neonatal Thyrotoxicosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Neonatal Thyrotoxicosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 17)
idRelated DiseaseScoreTop Affiliating Genes
1thyrotoxicosis31.4TSHR, TXNRD2
2hyperthyroidism30.3TXNRD2, TSHR
3hypothyroidism30.2TSHR, TXNRD2, LHX3
4thyroiditis10.6
5hypertension10.3
6hypertensive encephalopathy10.0
7hypoglycemia10.0
8infertility10.0
9graves' disease10.0
10congestive heart failure10.0
11craniosynostosis10.0
12thyroid adenoma10.0TXNRD2, TSHR
13goiter10.0TSHR, TXNRD2
14papillary thyroid carcinoma10.0TXNRD2, TSHR
15adenoma10.0TSHR, TXNRD2
16thyroid cancer10.0TXNRD2, TSHR
17hypersensitivity reaction type ii disease10.0TXNRD2, TSHR

Graphical network of diseases related to Neonatal Thyrotoxicosis:



Diseases related to neonatal thyrotoxicosis

Symptoms for Neonatal Thyrotoxicosis

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Drugs & Therapeutics for Neonatal Thyrotoxicosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Neonatal Thyrotoxicosis

Drug clinical trials:

Search ClinicalTrials for Neonatal Thyrotoxicosis

Search NIH Clinical Center for Neonatal Thyrotoxicosis

Search CenterWatch for Neonatal Thyrotoxicosis

Genetic Tests for Neonatal Thyrotoxicosis

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Anatomical Context for Neonatal Thyrotoxicosis

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34MalaCards
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MalaCards organs/tissues related to Neonatal Thyrotoxicosis:

34
Thyroid, Heart, Pituitary, Testes

Animal Models for Neonatal Thyrotoxicosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Neonatal Thyrotoxicosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.7LHX3, TSHR
2MP:00036318.5LHX3, TXNRD2, TSHR
3MP:00107688.5LHX3, TXNRD2, TSHR
4MP:00053768.4LHX3, TXNRD2, TSHR

Publications for Neonatal Thyrotoxicosis

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53PubMed
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Articles related to Neonatal Thyrotoxicosis:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Fetal and neonatal thyrotoxicosis. (24251220)
2013
2
Persistent neonatal thyrotoxicosis in a neonate secondary to a rare thyroid-stimulating hormone receptor activating mutation: case report and literature review. (18558604)
2008
3
Neonatal thyrotoxicosis and persistent pulmonary hypertension necessitating extracorporeal life support. (15629961)
2005
4
A case report of neonatal thyrotoxicosis due to maternal autoimmune hyperthyroidism. (14695499)
2003
5
Neonatal thyrotoxicosis and conjugated hyperbilirubinemia. (12962270)
2003
6
Neonatal thyrotoxicosis and maternal infertility in thyroid hormone resistance due to a mutation in the TRbeta gene (M313T). (12201835)
2002
7
The relationship between maternal serum thyroid-stimulating immunoglobulin and fetal and neonatal thyrotoxicosis. (12052596)
2002
8
Congenital neonatal thyrotoxicosis and previous maternal radioiodine therapy. (10797041)
2000
9
Hypertensive encephalopathy in a patient with neonatal thyrotoxicosis. (10486076)
1999
10
Congenital chylothorax in neonatal thyrotoxicosis. (10685206)
1999
11
Thyrotropin receptor antibodies associated with post-operative relapse of thyrotoxicosis in a pregnancy complicated by neonatal thyrotoxicosis. (2315685)
1990
12
Diminished thyroid-stimulating hormone secretion associated with neonatal thyrotoxicosis. (3093659)
1986
13
Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis. (2874029)
1986
14
Neonatal thyrotoxicosis treated with exchange transfusion and Lugol's iodine. (2859196)
1985
15
Effects of L-thyroxine treatment on pituitary GH content of adult rats with neonatal thyrotoxicosis. (6637335)
1983
16
Complications of propranolol use in neonatal thyrotoxicosis. (7395835)
1980
17
Is propranolol alone really beneficial in neonatal thyrotoxicosis? Bradycardia and hypoglycemia evoke the doctrine of primum non nocere. (6998280)
1980
18
Neonatal thyrotoxicosis: a rare pediatric emergency. (6893645)
1980
19
Neonatal thyrotoxicosis: intellectual impairment and craniosynostosis in later years. (7400892)
1980
20
Oxygen consumption in the rat following neonatal thyrotoxicosis. (488304)
1979
21
Neonatal thyrotoxicosis in four siblings born to a previously thyrotoxic mother. (717342)
1978
22
The role of thyroid stimulating immunoglobulins of Graves's disease in neonatal thyrotoxicosis. (581471)
1978
23
Neonatal thyrotoxicosis: alterations in serum concentrations of LATS-protector, T4, T3, reverse T3, and 3,3'T2. (650321)
1978
24
Neonatal thyrotoxicosis following maternal hypothyroidism. (619059)
1978
25
The behaviour of thyroid hormones in an infant with untreated neonatal thyrotoxicosis. (908154)
1977
26
Neonatal thyrotoxicosis. (899782)
1977
27
Neonatal thyrotoxicosis. (909013)
1977
28
The possible relation between postpartum exacerbation of hyperthyroidism and neonatal thyrotoxicosis. (596245)
1977
29
Neonatal thyrotoxicosis with long acting thyroid stimulator-protector. (576864)
1977
30
Neonatal thyrotoxicosis associated with the hyperviscosity syndrome. (830919)
1977
31
Neonatal thyrotoxicosis is associated with transplacental passage of human thyroid stimulating immunoglobulin (HTSI). (962368)
1976
32
Humoral and genetic factors in thyrotoxic Graves disease and neonatal thyrotoxicosis. (946443)
1976
33
Attempted prevention of neonatal thyrotoxicosis. (990790)
1976
34
Attempted prevention of neonatal thyrotoxicosis. (1000245)
1976
35
Congestive heart failure in neonatal thyrotoxicosis. A curable casue of heart failure in the newborn. (1192685)
1975
36
Neonatal thyrotoxicosis. (1134079)
1975
37
Persistent abnormalities in pituitary function following neonatal thyrotoxicosis in the rat. (4208653)
1974
38
Neonatal thyrotoxicosis treated with propranolol. (4429365)
1974
39
Propranolol in treatment of neonatal thyrotoxicosis. (4757519)
1973
40
Neonatal thyrotoxicosis. (4800423)
1973
41
The role of long acting thyroid stimulator in neonatal thyrotoxicosis. (4677121)
1972
42
Skeletal changes in neonatal thyrotoxicosis. (5008137)
1972
43
Neonatal thyrotoxicosis. Elevated long-acting thyroid stimulator (LATS) in mother and infant. (5762465)
1969
44
Neonatal thyrotoxicosis. (4185737)
1969
45
Neonatal thyrotoxicosis. (5645973)
1968
46
A case of neonatal thyrotoxicosis. (5588736)
1967
47
Neonatal thyrotoxicosis associated with maternal hypothyroidism. (4159675)
1966
48
Neonatal thyrotoxicosis: report of three cases involving four infants. (4168753)
1966
49
Survival time of circulating long-acting thyroid stimulator in neonatal thyrotoxicosis: implications for diagnosis and therapy of the disorder. (5846829)
1965
50
Neonatal thyrotoxicosis. (13731873)
1960

Variations for Neonatal Thyrotoxicosis

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Expression for genes affiliated with Neonatal Thyrotoxicosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neonatal Thyrotoxicosis

Search GEO for disease gene expression data for Neonatal Thyrotoxicosis.

Pathways for genes affiliated with Neonatal Thyrotoxicosis

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Compounds for genes affiliated with Neonatal Thyrotoxicosis

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 3BitterDB, 52PharmGKB, 30IUPHAR
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Compounds related to Neonatal Thyrotoxicosis according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1triiodothyronine469.7TXNRD2, TSHR
2asparagine469.6TSHR, TXNRD2
3cytosine46 2510.6TXNRD2, TSHR
4adenine46 25 1211.6TXNRD2, TSHR
5thyroxine46 2510.6TSHR, TXNRD2
6valine469.6TSHR, TXNRD2
7guanine46 25 1211.6TXNRD2, TSHR
8chloramphenicol46 3 52 1212.6TXNRD2, TSHR
9methionine469.5TXNRD2, TSHR
10proline469.5TSHR, TXNRD2
11hydrogen46 2510.5TSHR, TXNRD2
12thymidine46 2510.4TXNRD2, TSHR
13aspartate469.4TXNRD2, TSHR
14leucine469.3TSHR, TXNRD2
15phosphatidylinositol469.3TSHR, TXNRD2
16cholesterol46 30 25 1212.2TXNRD2, TSHR
17arginine469.0TSHR, TXNRD2
18cysteine468.8LHX3, TXNRD2, TSHR
19tyrosine468.7TSHR, TXNRD2, LHX3

GO Terms for genes affiliated with Neonatal Thyrotoxicosis

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Products for genes affiliated with Neonatal Thyrotoxicosis

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  • Antibodies
  • Proteins
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Sources for Neonatal Thyrotoxicosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet