MCID: NVS001
MIFTS: 48

Neovascular Glaucoma

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Neovascular Glaucoma

MalaCards integrated aliases for Neovascular Glaucoma:

Name: Neovascular Glaucoma 12 55 14
Glaucoma, Neovascular 41 69
Secondary Angle-Closure Glaucoma with Rubeosis 12
Glaucoma Neovascular 51

Characteristics:

Orphanet epidemiological data:

55
neovascular glaucoma
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 55  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:1687
MeSH 41 D015355
Orphanet 55 ORPHA94058
MESH via Orphanet 42 D015355
UMLS via Orphanet 70 C0017609
UMLS 69 C0017609

Summaries for Neovascular Glaucoma

MalaCards based summary : Neovascular Glaucoma, also known as glaucoma, neovascular, is related to microvascular complications of diabetes 5 and microvascular complications of diabetes 1, and has symptoms including visual loss, iris neovascularization and retinal vein occlusion. An important gene associated with Neovascular Glaucoma is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Endochondral Ossification and Cell adhesion_Plasmin signaling. The drugs Bevacizumab and Ranibizumab have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and testes.

Related Diseases for Neovascular Glaucoma

Diseases related to Neovascular Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 microvascular complications of diabetes 5 30.5 PGF VEGFA
2 microvascular complications of diabetes 1 30.5 TGFB2 VEGFA
3 coats disease 30.4 RS1 VEGFA
4 retinal detachment 30.1 RS1 VEGFA
5 arteries, anomalies of 29.6 PGF VEGFA
6 endophthalmitis 29.5 OPTN VEGFA
7 glaucoma, primary open angle 28.9 OPTN SLC6A13 TGFB2
8 retinoschisis 1, x-linked, juvenile 11.4
9 retinitis 10.5
10 endotheliitis 10.3
11 melanoma 10.3
12 retinal vein occlusion 10.3
13 preretinal fibrosis 10.3 TGFB2 VEGFA
14 central retinal vein occlusion 10.3
15 epithelioid hemangioendothelioma 10.2 PGF VEGFA
16 macular holes 10.2 TGFB2 VEGFA
17 cancer-associated retinopathy 10.2 PGF VEGFA
18 vitreous disease 10.2 TGFB2 VEGFA
19 microvascular complications of diabetes 2 10.2
20 choroiditis 10.2
21 rubeosis iridis 10.2
22 kuhnt-junius degeneration 10.2 PGF VEGFA
23 retinal vascular occlusion 10.2 PGF VEGFA
24 ectopic pregnancy 10.1 PGF VEGFA
25 limb ischemia 10.1 PGF VEGFA
26 retinal artery occlusion 10.1
27 placental insufficiency 10.1 PGF VEGFA
28 melanoma, uveal 10.1
29 cataract 10.1
30 diabetes mellitus 10.1
31 severe pre-eclampsia 10.1 PGF VEGFA
32 rosacea 10.0 IER3IP1 VEGFA
33 neurofibromatosis, type iv, of riccardi 10.0
34 central retinal artery occlusion 10.0
35 ischemia 10.0
36 carotid artery occlusion 10.0
37 yemenite deaf-blind hypopigmentation syndrome 10.0 OPTN VEGFA
38 blood group, globoside system 10.0 OPTN VEGFA
39 carotid artery disease 10.0
40 chronic closed-angle glaucoma 9.9 OPTN TGFB2
41 hereditary hemorrhagic telangiectasia 9.9 TGFB2 VEGFA
42 purulent endophthalmitis 9.9 OPTN VEGFA
43 lens disease 9.9 OPTN VEGFA
44 polyarteritis nodosa, childhood-onset 9.9
45 retinal ischemia 9.9
46 neuroretinitis 9.9
47 retinal vasculitis 9.9
48 sympathetic ophthalmia 9.9
49 branch retinal artery occlusion 9.9
50 optic nerve glioma 9.9

Graphical network of the top 20 diseases related to Neovascular Glaucoma:



Diseases related to Neovascular Glaucoma

Symptoms & Phenotypes for Neovascular Glaucoma

Human phenotypes related to Neovascular Glaucoma:

55 31 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 visual loss 55 31 hallmark (90%) Very frequent (99-80%) HP:0000572
2 iris neovascularization 55 31 hallmark (90%) Very frequent (99-80%) HP:0011497
3 retinal vein occlusion 55 31 hallmark (90%) Very frequent (99-80%) HP:0012636
4 abnormality of the optic nerve 55 31 frequent (33%) Frequent (79-30%) HP:0000587
5 photophobia 55 31 frequent (33%) Frequent (79-30%) HP:0000613
6 increased intraocular pressure 55 31 frequent (33%) Frequent (79-30%) HP:0007906
7 visual acuity test abnormality 55 31 frequent (33%) Frequent (79-30%) HP:0030532
8 ocular pain 55 31 frequent (33%) Frequent (79-30%) HP:0200026
9 abnormality of central retinal artery 55 31 frequent (33%) Frequent (79-30%) HP:3000032
10 retinal vascular proliferation 55 31 occasional (7.5%) Occasional (29-5%) HP:0007850
11 corneal stromal edema 55 31 occasional (7.5%) Occasional (29-5%) HP:0012040
12 retinal detachment 55 31 very rare (1%) Very rare (<4-1%) HP:0000541
13 glaucoma 55 Obligate (100%)
14 abnormality of the uvea 55 Frequent (79-30%)
15 abnormality of the anterior chamber 55 Occasional (29-5%)
16 abnormality of the posterior segment of the globe 55 Occasional (29-5%)
17 abnormal anterior chamber morphology 31 occasional (7.5%) HP:0000593

Drugs & Therapeutics for Neovascular Glaucoma

Drugs for Neovascular Glaucoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 216974-75-3
2
Ranibizumab Approved Phase 4,Phase 3,Phase 2,Phase 1 347396-82-1 459903
3 Angiogenesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
4 Angiogenesis Modulating Agents Phase 4,Phase 3,Phase 2,Phase 1
5 Endothelial Growth Factors Phase 4,Phase 3,Phase 1,Phase 2
6 Mitogens Phase 4,Phase 3,Phase 2,Phase 1
7 Mitomycins Phase 4,Phase 3,Phase 2
8
Triamcinolone Approved, Vet_approved Phase 2, Phase 3 124-94-7 31307
9 Anti-Inflammatory Agents Phase 2, Phase 3
10 glucocorticoids Phase 2, Phase 3
11 Hormone Antagonists Phase 2, Phase 3
12 Hormones Phase 2, Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
14 Immunosuppressive Agents Phase 2, Phase 3
15 triamcinolone acetonide Phase 2, Phase 3
16 Triamcinolone diacetate Phase 2, Phase 3
17 Triamcinolone hexacetonide Phase 2, Phase 3
18 Alkylating Agents Phase 3,Phase 2
19 Anti-Bacterial Agents Phase 3,Phase 2
20 Antibiotics, Antitubercular Phase 3,Phase 2
21 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
22 Pharmaceutical Solutions Phase 2, Phase 3,Phase 1
23 insulin Phase 2, Phase 3
24 Insulin, Globin Zinc Phase 2, Phase 3
25 Anesthetics Phase 2
26
Epinephrine Approved, Vet_approved 51-43-4 5816
27 Racepinephrine Approved 329-65-7
28
Pilocarpine Approved, Investigational 92-13-7, 54-71-7 5910
29 Epinephryl borate
30 Autonomic Agents
31 Cholinergic Agents
32 Neurotransmitter Agents
33 Peripheral Nervous System Agents

Interventional clinical trials:

(show all 42)

# Name Status NCT ID Phase Drugs
1 Comparison of Silicone and Porous Plate Ahmed Glaucoma Valves Unknown status NCT01883856 Phase 4
2 Intravitreous Ranibizumab as Adjunctive Treatment for Trabeculectomy in Neovascular Glaucoma Completed NCT01922154 Phase 4 intravitreal ranibizumab
3 Intravitreal Ranibizumab Injection as Adjuvant in the Treatment of Postvitrectomy Diabetic Vitreous Hemorrhage Accompanied by Neovascular Glaucoma Completed NCT02647515 Phase 4 ranibizumab
4 Intraocular Bevacizumab (Avastin) for Rubeosis Iridis Completed NCT00557232 Phase 4 bevacizumab
5 Prospective Randomized Controlled Study of Intravitreal Injection of Bevacizumab for Proliferative Diabetic Retinopathy Completed NCT01854593 Phase 4 Bevacizumab
6 Evaluation of Efficacy and Safety of Susanna Implant in Patients With Refractory Glaucoma. Unknown status NCT01314170 Phase 3
7 Ahmed Valve Glaucoma Implant With Adjunctive Subconjunctival Bevacizumab in Refractory Glaucoma Unknown status NCT01128699 Phase 3 Subconjunctival Avastin
8 Japanese Phase 3 Study of Aflibercept in Neovascular Glaucoma Patients Completed NCT02396316 Phase 3 Aflibercept (Eylea, BAY 86-5321);Sham Injection
9 Intravitreal Aflibercept or Ranibizumab for Rubeosis Iridis Completed NCT02641457 Phase 3 Aflibercept;Ranibizumab
10 Long-term Treatment Effect of Intravitreal Ant-VEGF in Branch Retinal Vein Occlusion Completed NCT02033031 Phase 3 Lucentis intravitreal injection;Avastin intravitreal injection
11 Bevacizumab for Central Retinal Vein Occlusion Study Completed NCT00906685 Phase 3 bevacizumab;Sham bevacizumab injection
12 An Open-label Extended Clinical Protocol of Ranibizumab to Evaluate Safety and Efficacy in Rare VEGF Driven Ocular Diseases. Completed NCT01908816 Phase 3 ranibizumab
13 Oculusgen (Ologen) Glaucoma MMC Control in Estonia Completed NCT00524758 Phase 3 MMC in Trabeculectomy
14 Will the Use of Triesence During Glaucoma Surgery Provide Lower Eye Pressure and Improve the Results of the Surgery? Completed NCT00853905 Phase 2, Phase 3 Triesence;balanced salt solution BSS
15 Prevention of Neovascular Glaucoma by Intravitreal Injections of Anti-VEGF in Patients Treated With Proton Therapy for a Large Choroidal Melanoma Not yet recruiting NCT03172299 Phase 3 Aflibercept Injection;False injection
16 Intravitreal Ranibizumab (Lucentis®) for Neovascular Glaucoma- a Randomized Controlled Study Not yet recruiting NCT02914626 Phase 3 Intravitreal ranibizumab
17 Trial of Aganirsen in iCRVO Patients at Risk of Developing NVG Not yet recruiting NCT02947867 Phase 2, Phase 3 aganirsen
18 Avastin as an Adjunct to Diode Laser in the Treatment of Neovascular Glaucoma Completed NCT01051583 Phase 2
19 Analysis of Aqueous and Vitreous Humor Recruiting NCT02067013 Phase 2 Ranibizumab
20 Phase II Evaluating Endoresection of the Tumor Scar or Transpupillary Thermotherapy When Endoresection is Not Feasible After Proton Beam Therapy for the Treatment of Large Uveal Melanomas (Endoresection-Laser) Recruiting NCT02874040 Phase 2
21 The Efficacy of Intravitreal Aflibercept Injection in Improvement of Retinal Nonperfusion in Diabetic Retinopathy Recruiting NCT03006081 Phase 2 Intravitreal Aflibercept injection
22 Ahmed Glaucoma Valve Surgery With Mitomycin-C Recruiting NCT02805257 Phase 2 Mitomycin-C
23 Study of the Efficacy and Tolerability of Intravitreal Injections of Ranibizumab Compared to Intravitreal Injections of Ranibizumab Combined With Targeted Retinal Photocoagulation to Treat Radiation Retinopathy. Active, not recruiting NCT02222610 Phase 2 0.5 mg ranibizumab
24 Lucentis for New Onset Neovascular Glaucoma Withdrawn NCT00727038 Phase 1, Phase 2 Ranibizumab (Lucentis)
25 Rubeosis Anti-VEGF (RAVE) Trial for Ischemic Central Retinal Vein Occlusion Completed NCT00406471 Phase 1 Ranibizumab (Lucentis)
26 A Pilot Study for the Treatment of Iris Neovascularization With Macugen Completed NCT00295828 Phase 1
27 Comparative Study, Safety and Efficacy, Ahmed Glaucoma Drainage Device, Model M4 Model S2 in Neovascular Glaucoma Unknown status NCT02260219
28 Comparison of Efficacy Between Silicone Ahmed Glaucoma Valves With and Without Intravitreal Triamcinolone Injection Unknown status NCT00491712
29 Triamcinolone for Ahmed Glaucoma Valve Unknown status NCT02653963 Adjunctival Triamcinolone
30 Prevalence of Glaucoma in the Israeli Arab Population Unknown status NCT01546740
31 Study to Evaluate the Effects of Ranibizumab (Lucentis) for Patients With Rubeosis and Neovascular Glaucoma Completed NCT01370135 0.5mg intraocular Ranibizumab (Lucentis)
32 Use of Intravitreal Aflibercept Injection for Neovascular Glaucoma Completed NCT01711879 Aflibercept
33 Intravitreal Bevacizumab for Neovascular Glaucoma Completed NCT00384631 Avastin
34 Comparison of Small-gauge Vitrectomy and Conventional Vitrectomy for Proliferative Diabetic Retinopathy Completed NCT01758757
35 Comparison of Subconjuctival Versus Topical Bevacizumab as Adjunct Therapy to Trabeculectomy Completed NCT01425112
36 Retrospective Data Analysis of Patients Treated for Macular Edema Due to Central Retinal Vein Occlusion Completed NCT02645747 aflibercept (Eylea, Bay 86-5321)
37 the Pops-titration Versus the Slow-coagulation Cyclophotocoagulation in Treatment of Refractory Glaucoma Completed NCT01774227
38 The Effect of Conbercept Injection Through Different Routes for Neovascular Glaucoma Recruiting NCT03154892
39 Anterior Segment Imaging With Ultrahigh-resolution OCT in Patients With Glaucoma and PEX - a Pilot Study Recruiting NCT02865473 Pilocarpine
40 Patch Graft Material Safety and Effectiveness in Covering Glaucoma Drainage Device Tube Terminated NCT01301378
41 Radial Optic Neurotomy in Central Retinal Vein Occlusion : a Randomized Trial Terminated NCT00379223
42 Effects of Travoprost on Neovascular Glaucoma Withdrawn NCT00441181 Travoprost

Search NIH Clinical Center for Neovascular Glaucoma

Cochrane evidence based reviews: glaucoma, neovascular

Genetic Tests for Neovascular Glaucoma

Anatomical Context for Neovascular Glaucoma

MalaCards organs/tissues related to Neovascular Glaucoma:

38
Eye, Endothelial, Testes, Retina, B Cells, Placenta, Lung

Publications for Neovascular Glaucoma

Articles related to Neovascular Glaucoma:

(show top 50) (show all 409)
# Title Authors Year
1
Rapidly progressive neovascular glaucoma following coronary artery bypass graft surgery in a patient with type 1 diabetes mellitus: a case report. ( 29429414 )
2018
2
Systemic diffuse large B-cell lymphoma masquerading as neovascular glaucoma. ( 29380792 )
2018
3
Intravitreal bevacizumab for neovascular glaucoma in uveal melanoma treated by proton beam therapy. ( 29116399 )
2018
4
Effect of Preoperative Intravitreal Bevacizumab on the Surgical Outcome of Neovascular Glaucoma at Different Stages. ( 28713590 )
2017
5
Changing epidemiology of neovascular glaucoma from 2002 to 2012 at King Khaled Eye Specialist Hospital, Saudi Arabia. ( 29044062 )
2017
6
Clinical Features of Ocular Ischemic Syndrome and Risk Factors for Neovascular Glaucoma. ( 28682017 )
2017
7
Choroidal hypoperfusion: an indicator of low tension neovascular glaucoma. ( 29256166 )
2017
8
Surgical treatment of neovascular glaucoma with Ex-PRESS glaucoma shunt: Case report. ( 28858093 )
2017
9
Efficacy and Safety of Intracameral Bevacizumab for Treatment of Neovascular Glaucoma. ( 29022296 )
2017
10
The efficacy of Alahmady ring implantation in the management of neovascular glaucoma. ( 28356708 )
2017
11
Central retinal artery occlusion without underlying chronic ocular ischemic syndrome may lead to neovascular glaucoma. ( 29055729 )
2017
12
Association of Neovascular Glaucoma with Risk of Stroke: A Population-Based Cohort Study. ( 28928981 )
2017
13
Neovascular glaucoma after vitrectomy in patients with proliferative diabetic retinopathy. ( 28272234 )
2017
14
Clinical efficacy analysis of Ahmed glaucoma valve implantation in neovascular glaucoma and influencing factors: A STROBE-compliant article. ( 29049253 )
2017
15
Ahmed valves vs trabeculectomy combined with pans plana vitrectomy for neovascular glaucoma with vitreous hemorrhage. ( 28430329 )
2017
16
Circumpapillary retinal nerve fiber layer thickness, anterior lamina cribrosa depth, and lamina cribrosa thickness in neovascular glaucoma secondary to proliferative diabetic retinopathy: a cross-sectional study. ( 28446148 )
2017
17
Chronic Retinal Necrosis Severely Complicated by Neovascular Glaucoma: A Case Report. ( 29282399 )
2017
18
Short-term outcomes after EX-PRESS implantation versus trabeculectomy alone in patients with neovascular glaucoma. ( 29276376 )
2017
19
Glaucoma drainage device implantation with adjunctive intravitreal bevacizumab in neovascular glaucoma: 3-year experience. ( 28848323 )
2017
20
A prospective, randomised, placebo-controlled, double-masked, three-armed, multicentre phase II/III trial for the Study of a Topical Treatment of Ischaemic Central Retinal Vein Occlusion to Prevent Neovascular Glaucoma - the STRONG study: study protocol for a randomised controlled trial. ( 28302155 )
2017
21
Neovascular glaucoma after proton beam therapy of choroidal melanoma: incidence and risk factors. ( 28721444 )
2017
22
Management of neovascular glaucoma with intravitreal ranibizumab, panretinal photocoagulation, and subsequent 5-fluorouracil augmented trabeculectomy: A case report. ( 28640115 )
2017
23
Efficacy and safety of intravitreal ranibizumab with panretinal photocoagulation followed by trabeculectomy compared with Ahmed glaucoma valve implantation in neovascular glaucoma. ( 28393031 )
2017
24
Intracameral air injection during Ahmed glaucoma valve implantation in neovascular glaucoma for the prevention of tube obstruction with blood clot: Case Report. ( 29390305 )
2017
25
Long-Term Outcome of Intravitreal Bevacizumab Followed by Ahmed Valve Implantation in the Management of Neovascular Glaucoma. ( 28992424 )
2017
26
Neovascular Glaucoma: A Retrospective Review from a Tertiary Eye Care Center in Mexico. ( 28924338 )
2017
27
Reply to 'Comment on: Long-term outcomes of neovascular glaucoma treated with and without intravitreal bevacizumab'. ( 26939556 )
2016
28
Placenta Growth Factor in Eyes with Neovascular Glaucoma Is Decreased after Intravitreal Ranibizumab Injection. ( 26785251 )
2016
29
Neovascular glaucoma: a review. ( 27895936 )
2016
30
Role of Platelet Parameters on Neovascular Glaucoma: A Retrospective Case-Control Study in China. ( 27907042 )
2016
31
Outcomes of 23-Gauge Vitrectomy Combined with Phacoemulsification, Panretinal Photocoagulation, and Trabeculectomy without Use of Anti-VEGF Agents for Neovascular Glaucoma with Vitreous Hemorrhage. ( 26885379 )
2016
32
Comparative study of the safety and efficacy of the Ahmed glaucoma valve model M4 (high density porous polyethylene) and the model S2 (polypropylene) in patients with neovascular glaucoma. ( 27068138 )
2016
33
Decompression retinopathy after intravitreal bevacizumab and anterior chamber paracentesis in a patient with neovascular glaucoma. ( 27958217 )
2016
34
Intravitreal ranibizumab injection combined trabeculectomy versus Ahmed valve surgery in the treatment of neovascular glaucoma: assessment of efficacy and complications. ( 27230388 )
2016
35
Efficacy of intravitreal ranibizumab combined with Ahmed glaucoma valve implantation for the treatment of neovascular glaucoma. ( 26749079 )
2016
36
Prognostic Factor Analysis of Intraocular Pressure with Neovascular Glaucoma. ( 27579175 )
2016
37
Comment on: 'Long-term outcomes of neovascular glaucoma treated with and without intravitreal bevacizumab'. ( 26939563 )
2016
38
Study of the Effect of Injection Bevacizumab through Various Routes in Neovascular Glaucoma. ( 27536046 )
2016
39
Preoperative intravitreal injection of ranibizumab for patients with severe proliferative diabetic retinopathy contributes to a decreased risk of postoperative neovascular glaucoma. ( 27010230 )
2016
40
Neovascular Glaucoma. ( 26501989 )
2016
41
Neovascular glaucoma: a retrospective review from a tertiary center in China. ( 26818828 )
2016
42
Evaluation of Ex-PRESS mini glaucoma shunt implantation with preoperative intracameral bevacizumab injection in refractory neovascular glaucoma. ( 26951529 )
2016
43
Anti-VEGF treatment is the key strategy for neovascular glaucoma management in the short term. ( 27576739 )
2016
44
Bilateral neovascular glaucoma in idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome. ( 27085273 )
2016
45
Management of intraocular pressure elevation during hemodialysis of neovascular glaucoma: a case report. ( 26944556 )
2016
46
Paradoxical development of neovascular glaucoma following carotid angioplasty and stenting. ( 27341857 )
2016
47
Intravitreal Ranibizumab Injection as an Adjuvant in the Treatment of Neovascular Glaucoma Accompanied by Vitreous Hemorrhage after Diabetic Vitrectomy. ( 27293875 )
2016
48
Long-term outcomes of neovascular glaucoma treated with and without intravitreal bevacizumab. ( 26681145 )
2016
49
Conjunctival Microangiopathy in a Patient with Neovascular Glaucoma. ( 26557840 )
2015
50
Levels of angiogenesis-related vascular endothelial growth factor family in neovascular glaucoma eyes. ( 25783445 )
2015

Variations for Neovascular Glaucoma

Expression for Neovascular Glaucoma

Search GEO for disease gene expression data for Neovascular Glaucoma.

Pathways for Neovascular Glaucoma

Pathways related to Neovascular Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.97 TGFB2 VEGFA
2 10.65 TGFB2 VEGFA
3
Show member pathways
9.83 PGF VEGFA

GO Terms for Neovascular Glaucoma

Cellular components related to Neovascular Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.62 TGFB2 VEGFA

Biological processes related to Neovascular Glaucoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.5 PGF TGFB2 VEGFA
2 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.49 PGF VEGFA
3 activation of protein kinase activity GO:0032147 9.48 TGFB2 VEGFA
4 positive regulation of endothelial cell proliferation GO:0001938 9.46 PGF VEGFA
5 cellular response to hormone stimulus GO:0032870 9.43 PGF UCP2
6 heart morphogenesis GO:0003007 9.4 TGFB2 VEGFA
7 cell death GO:0008219 9.37 OPTN TGFB2
8 induction of positive chemotaxis GO:0050930 9.26 PGF VEGFA
9 positive regulation of mast cell chemotaxis GO:0060754 9.16 PGF VEGFA
10 positive regulation of cell division GO:0051781 9.13 PGF TGFB2 VEGFA
11 response to hypoxia GO:0001666 8.92 PGF TGFB2 UCP2 VEGFA

Molecular functions related to Neovascular Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 PGF TGFB2 VEGFA
2 vascular endothelial growth factor receptor binding GO:0005172 8.62 PGF VEGFA

Sources for Neovascular Glaucoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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