MCID: NPH051
MIFTS: 54

Nephritis malady

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Summaries for Nephritis

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Wikipedia:65 Nephritis is inflammation of the kidneys and may involve the glomeruli, tubules, or interstitial tissue... more...

MalaCards based summary: Nephritis is related to systemic lupus erythematosus and purpura. An important gene associated with Nephritis is TINAG (tubulointerstitial nephritis antigen), and among its related pathways are Tuberculosis and B Cell Receptor Signaling Pathway. The drug magnesium sulfate and the compounds gluten and natalizumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and monocytes, and related mouse phenotypes are renal/urinary system and vision/eye.

Aliases & Classifications for Nephritis

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Sources:
10DISEASES, 44Novoseek, 62UMLS
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Nephritis, Aliases & Descriptions:

Name: Nephritis 10 44 62


Related Diseases for Nephritis

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Diseases related to Nephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 409)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus31.9FCGR2A
2purpura31.9CD79A
3alport syndrome31.4COL4A5, CD79A
4uveitis31.1CXCR3, CCL2, LTA
5lupus erythematosus31.1APOH, IL18, CD79A, CD40LG
6acute poststreptococcal glomerulonephritis31.0CD79A
7tuberculosis30.8CD79A, IL18, CXCR3
8proliferative glomerulonephritis30.8CD79A, CCL2, CXCR3
9vasculitis30.6APOH, CCL2, CD79A, CD40LG
10membranous glomerulonephritis30.6LRP2, TINAG, CCL2, CD79A
11q fever30.5CD79A
12focal segmental glomerulosclerosis30.5CD79A, RBP4
13lipoid nephrosis30.5CCL2, CD79A
14autoimmune hemolytic anemia30.5CD79A, CD40LG
15glomerulonephritis30.5LRP2, FCGR2A, CCL2, COL4A5, RBP4, CD79A
16dermatitis30.4CXCR3, IL18, CD79A
17glomerulosclerosis30.4CD79A, COL4A5, CCL2
18infectious mononucleosis30.3CD79A, CD40LG
19eosinophilia30.3CD79A, GATA3, IL18
20proteinuria30.3LRP2, APOH, CCL2, COL4A5, RBP4, CD79A
21pneumonia30.2CCL2, RBP4, CD79A
22sarcoidosis30.2LTA, IL18, CCL2, CXCR3
23berger disease30.2CCL2, CD79A, CD40LG
24hepatitis30.2LTA, CD40LG, IL18
25antiphospholipid syndrome30.2APOH, CD79A, CD40LG
26primary biliary cirrhosis30.2CD79A, CD40LG, LTA
27hepatitis c30.2CD40LG, IL18, CXCR3
28diabetic nephropathy30.2CCL2, IL18, RBP4
29connective tissue disease30.1APOH, CCL2, CD79A, CD40LG
30agammaglobulinemia30.1CD79A, CD40LG
31skin disease30.1CXCR3, IL18, CD79A
32interstitial lung disease30.0CD79A, CCL2
33cryoglobulinemia30.0CD40LG, CD79A, APOH
34tonsillitis29.9LTA, CD79A
35influenza29.9LTA, CD79A, CXCR3
36chronic lymphocytic leukemia29.9CXCR3, CD40LG, LTA
37thrombocytopenia29.9APOH, FCGR2A, FCGR3A, CD79A, CD40LG
38diabetes mellitus29.8CD40LG, CD79A, RBP4, CCL2
39common variable immunodeficiency29.8CD79A, CD40LG
40graves' disease29.7LRP2, CXCR3, LTA
41ulcerative colitis29.7LTA, CD79A, IL18, CXCR3
42lupus nephritis29.7CXCR3, CCL2, IL18, GATA3, RBP4, CD79A
43arthritis29.6FCGR2A, FCGR3A, CXCR3, CCL2, IL18, LTA
44behcet's disease29.5LRP2, APOH, IL18, LTA
45rheumatic disease29.4APOH, FCGR2A, CXCR3, IL18, CD40LG
46leukemia29.4CXCR3, RBP4, CD79A, CD40LG, LTA
47atherosclerosis28.7LRP2, APOH, FCGR2A, CXCR3, CCL2, IL18
48rheumatoid arthritis28.0LRP2, APOH, LTA, CD40LG, CD79A, GATA3
49interstitial nephritis11.2
50tubulointerstitial nephritis and uveitis10.8

Graphical network of the top 20 diseases related to Nephritis:



Diseases related to nephritis

Symptoms for Nephritis

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Drugs & Therapeutics for Nephritis

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Drug clinical trials:

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Search NIH Clinical Center for Nephritis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Nephritis

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Anatomical Context for Nephritis

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MalaCards organs/tissues related to Nephritis:

32
Kidney, T cells, Monocytes, B cells, Neutrophil, Endothelial, Bone, Liver, Skin, Thyroid, Bone marrow, Lung, Testes, Eye, Heart, Smooth muscle, Myeloid, Whole blood, Brain, Pancreas, Prostate, Tonsil

Animal Models for Nephritis or affiliated genes

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MGI Mouse Phenotypes related to Nephritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3LRP2, CXCR3, COL4A5, GATA3, CD79A, CD40LG
2MP:00053917.9LRP2, CCL2, IL18, GATA3, RBP4, LTA
3MP:00053907.6LRP2, FCGR2A, FCGR3A, CCL2, GATA3, CD40LG
4MP:00053847.6CXCR3, CCL2, IL18, GATA3, RBP4, CD79A
5MP:00053857.4CXCR3, CCL2, IL18, COL4A5, GATA3, RBP4
6MP:00053977.1FCGR2A, FCGR3A, CXCR3, CCL2, IL18, GATA3
7MP:00053876.9CCL2, CXCR3, FCGR3A, FCGR2A, IL18, COL4A5
8MP:00107686.8LRP2, APOH, FCGR2A, CXCR3, CCL2, IL18
9MP:00053766.4LTA, LRP2, APOH, FCGR3A, CXCR3, CCL2

Publications for Nephritis

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Articles related to Nephritis:

(show top 50)    (show all 1938)
idTitleAuthorsYear
1
Glomerular Autoimmune Multicomponents of Human Lupus Nephritis In Vivo (2): Planted Antigens. (25398787)
2014
2
Tubulointerstitial nephritis complicating IVIG therapy for X-linked agammaglobulinemia. (25005715)
2014
3
Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis with poor kidney function: a subgroup analysis of the Aspreva Lupus Management Study. (23375819)
2013
4
Varenicline induced acute interstitial nephritis in the setting of idiopathic membranous glomerulonephritis. (24215355)
2013
5
Cefpodoxime proxetil-related hemolysis and acute interstitial nephritis. (23845192)
2013
6
Long- and short-term treatment with imatinib attenuates the development of chronic kidney disease in experimental anti-glomerular basement membrane nephritis. (23045430)
2013
7
Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. (23896866)
2013
8
Serial non-invasive assessment of antibody induced nephritis in mice using positron emission tomography. (23460853)
2013
9
Survival analysis and causes of mortality in patients with lupus nephritis. (22523116)
2012
10
The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis. (22900150)
2012
11
Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis. (22128082)
2012
12
Long-term outcome of lupus nephritis in Asian Indians. (22232126)
2012
13
Herpes virus infection associated with interstitial nephritis in a beaked whale (Mesoplodon densirostris). (23237059)
2012
14
Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus. (21163672)
2011
15
The role of cytokines as biomarkers in systemic lupus erythematosus and lupus nephritis. (21372259)
2011
16
Predictive value of remission status after 6A months induction therapy in patients with proliferative lupus nephritis: a retrospective analysis. (21594768)
2011
17
Acute interstitial nephritis. (20336051)
2010
18
The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans. (20523037)
2010
19
Estimation of monocyte-chemoattractantprotein-1 (Mcp-1) level in patients with lupus nephritis. (20374368)
2009
20
C/EBP-beta modulates transcription of tubulointerstitial nephritis antigen in obstructive uropathy. (19297554)
2009
21
Relationship between integrin-linked kinase expression and renal glomerular damage in children with Henoch-Schnlein purpura nephritis]. (20113654)
2009
22
Acute Tubular Necrosis and Interstitial Nephritis during Pemetrexed Therapy. (20740145)
2009
23
Is tubulointerstitial nephritis and uveitis syndrome associated with IgG4-related systemic disease? (18199112)
2008
24
A case report of adenovirus-related acute interstitial nephritis in a patient with AIDS. (18155541)
2008
25
Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis. (17530720)
2007
26
Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis. (16461436)
2006
27
Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosus. (16868980)
2006
28
IgA nephritis: ACE inhibitors, steroids, both or neither? (16980324)
2006
29
Mesangial cell Fas ligand: upregulation in human lupus nephritis and NF-kappaB-mediated expression in cultured human mesangial cells. (15480896)
2004
30
Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis. (15119544)
2004
31
Thrombotic thrombocytopenic purpura complicating SjAPgren's syndrome with crescentic glomerulonephritis and membranous nephritis. (17143670)
2004
32
Pathogenesis of acute viral disease induced in fish by carp interstitial nephritis and gill necrosis virus. (15308746)
2004
33
Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. (12556395)
2003
34
Antiphospholipid antibodies in patients with lupus nephritis. (14575283)
2003
35
Combining lisinopril and l-arginine slows disease progression and reduces endothelin-1 in passive Heymann nephritis. (12911535)
2003
36
Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. (12115187)
2002
37
Isolated sarcoid granulomatous interstitial nephritis: review of five cases at one center. (11334315)
2001
38
Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid. (11316248)
2001
39
Wegener's granulomatosis presenting as acute suppurative interstitial nephritis. (11577128)
2001
40
Anuric acute renal failure secondary to megalocytic interstitial nephritis in a patient with Behcet's disease. (11140812)
2000
41
Increased expression of cytoplasmic tail-containing form of gp600/megalin in active Heymann nephritis. (11004703)
2000
42
Association of anticardiolipin antibodies with intraglomerular thrombi and renal dysfunction in lupus nephritis. (9709458)
1998
43
Glomerular epithelial protein 1 and podocalyxin-like protein 1 in inflammatory glomerular disease (crescentic nephritis) in rabbit and man. (8600307)
1996
44
The syndrome of lung hemorrhage and nephritis is usually an ANCA-associated condition. (8607730)
1996
45
Acute hepatitis, interstitial nephritis, and eosinophilia. (7872595)
1995
46
Autosomal recessive Alport syndrome: mutation in the COL4A3 gene in a woman with Alport syndrome and posttransplant antiglomerular basement membrane nephritis. (7780062)
1995
47
Heymann nephritis revisited--new insights into the pathogenesis of experimental membranous glomerulonephritis. (8252799)
1993
48
Significance of anticardiolipin and antiendothelial cell antibodies in the nephritis of lupus. (1458929)
1992
49
Transient arthritis with positive tests for rheumatoid factor as presenting sign of shunt nephritis. (2015013)
1991
50
Anti-cardiolipin antibody and renal microthrombi in lupus nephritis]. (1767341)
1991

Variations for Nephritis

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Expression for genes affiliated with Nephritis

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Expression patterns in normal tissues for genes affiliated with Nephritis

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Pathways for genes affiliated with Nephritis

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Compounds for genes affiliated with Nephritis

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Compounds related to Nephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1gluten449.9APOH, CD79A, IL18
2natalizumab44 1110.7FCGR2A, IL18, FCGR3A
3adalimumab44 50 1111.7CD79A, FCGR3A, FCGR2A
4tuberculin449.5CD40LG, IL18, CD79A
5daclizumab44 1110.5FCGR2A, FCGR3A, CD40LG
6sulfolipid i449.5CD79A, CD40LG
7alemtuzumab44 1110.5FCGR3A, CD40LG, FCGR2A
8valine449.4COL4A5, FCGR3A, APOH, FCGR2A, RBP4
9lipoteichoic acid449.3APOH, IL18, LTA, CCL2
10il 10449.2LTA, CCL2, CXCR3, IL18
11abciximab44 1110.2CD40LG, FCGR3A, FCGR2A
12il-12449.2IL18, CCL2, CD40LG
13mannose449.2CD79A, FCGR3A, LTA, APOH, FCGR2A
14prednisolone44 28 1111.1LTA, IL18, FCGR2A, APOH, CD79A
15infliximab44 50 1111.1LTA, CXCR3, FCGR2A, APOH, IL18
16mycophenolate mofetil44 50 1111.1LTA, CD79A, CD40LG, IL18
17rituximab44 50 1111.1FCGR3A, FCGR2A, CD40LG, CD79A, APOH
18vitamin b12449.1CCL2, LRP2, APOH, CD79A, CD40LG
19methotrexate50 44 1111.1CD79A, GATA3, IL18, FCGR3A, APOH
20neopterin449.0IL18, CD79A, CD40LG, LTA
21fmlp449.0CXCR3, FCGR2A, FCGR3A, LTA, CCL2
22thyroxine44 2410.0LTA, LRP2, RBP4, CD79A, CD40LG
23folate448.9LRP2, IL18, CD79A, CD40LG, RBP4, APOH
24heparin44 28 24 1111.8APOH, CD79A, FCGR2A, CXCR3, CD40LG, LRP2
25etanercept44 50 1110.8FCGR2A, LTA, IL18, CXCR3, FCGR3A, APOH
26polysaccharide448.7CD79A, FCGR2A, CCL2, IL18, CD40LG
27allergens448.7GATA3, IL18, LRP2, CXCR3, CD79A, CD40LG
28fibrinogen448.7APOH, CCL2, CD79A, IL18, CD40LG
29histamine44 28 2410.6CD79A, CD40LG, IL18, CCL2, CXCR3, FCGR2A
30ivig448.6FCGR2A, CD40LG, LTA, CD79A, APOH, FCGR3A
31herbimycin a44 619.6LTA, FCGR3A, CD40LG, CCL2
32rantes448.6CD40LG, CXCR3, CCL2, IL18, LTA
33lactate448.5LTA, CD40LG, CD79A, RBP4, IL18, APOH
34progesterone44 28 61 24 1112.4IL18, CXCR3, APOH, GATA3, RBP4, LTA
35tgf beta1448.4GATA3, CCL2, IL18, LTA
36endotoxin448.4LTA, APOH, CD40LG, IL18, CCL2, CXCR3
37pge2448.4CCL2, IL18, CD79A, CD40LG, LTA, CXCR3
38creatinine448.4CD79A, CD40LG, APOH, CXCR3, CCL2, RBP4
39steroid448.2IL18, LTA, CD79A, RBP4, GATA3, CXCR3
40oxygen44 249.1FCGR2A, APOH, FCGR3A, CXCR3, CCL2, IL18
41vegf448.0CD40LG, APOH, LTA, CCL2, CD79A, IL18
42retinoic acid44 249.0LTA, RBP4, GATA3, CD40LG, CD79A, IL18
43cysteine448.0IL18, COL4A5, RBP4, CD79A, TINAG, TINAGL1
44lipid447.9RBP4, APOH, LRP2, FCGR2A, CCL2, IL18
45cholesterol44 28 24 1110.9APOH, LTA, IL18, LRP2, CXCR3, RBP4
46arginine447.8CCL2, COL4A5, APOH, CD79A, CD40LG, CXCR3
47estrogen447.8RBP4, IL18, CXCR3, CD79A, CD40LG, LTA
48dexamethasone44 50 28 1110.7CXCR3, IL18, CCL2, GATA3, RBP4, CD79A
49serine447.6LRP2, CD40LG, RBP4, COL4A5, IL18, CCL2
50calcium44 50 24 1110.2GATA3, LRP2, APOH, RBP4, IL18, FCGR2A

GO Terms for genes affiliated with Nephritis

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Cellular components related to Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7FCGR3A, CXCR3, CD79A, CD40LG
2extracellular regionGO:0055768.0RBP4, COL4A5, IL18, CCL2, TINAGL1, FCGR3A
3extracellular spaceGO:0056157.0LTA, CD40LG, RBP4, IL18, CCL2, TINAGL1

Biological processes related to Nephritis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:0600659.9RBP4, GATA3
2negative regulation of endothelial cell proliferationGO:0019379.9CXCR3, APOH
3lipopolysaccharide-mediated signaling pathwayGO:0316639.7IL18, CCL2
4negative regulation of angiogenesisGO:0165259.7CCL2, CXCR3, APOH
5response to gamma radiationGO:0103329.5CCL2, GATA3
6response to ethanolGO:0454719.5RBP4, GATA3, CCL2
7angiogenesisGO:0015259.4IL18, CCL2, CXCR3
8B cell proliferationGO:0421009.3CD40LG, CD79A
9humoral immune responseGO:0069599.3LTA, GATA3, CCL2
10inflammatory responseGO:0069549.0CXCR3, CCL2, IL18, CD40LG
11immune responseGO:0069558.8FCGR3A, TINAGL1, TINAG, IL18

Molecular functions related to Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:0198649.8FCGR3A, FCGR2A
2polysaccharide bindingGO:0302479.4TINAG, TINAGL1
3tumor necrosis factor receptor bindingGO:0051649.3LTA, CD40LG
4cytokine activityGO:0051258.7LTA, CD40LG, IL18

Products for genes affiliated with Nephritis

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Sources for Nephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet