Summaries for Nephritis

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Wikipedia:65 Nephritis is inflammation of the kidneys and may involve the glomeruli, tubules, or interstitial tissue... more...

MalaCards based summary: Nephritis is related to lupus nephritis and uveitis. An important gene associated with Nephritis is TINAG (tubulointerstitial nephritis antigen), and among its related pathways are Tuberculosis and B Cell Receptor Signaling Pathway. The drug magnesium sulfate and the compounds gluten and natalizumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and monocytes, and related mouse phenotypes are renal/urinary system and vision/eye.

Aliases & Classifications for Nephritis

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Sources:
12DISEASES, 45Novoseek, 62UMLS
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Nephritis, Aliases & Descriptions:

Name: Nephritis 12 45 62


Related Diseases for Nephritis

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Diseases related to Nephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 398)
idRelated DiseaseScoreTop Affiliating Genes
1lupus nephritis31.6CXCR3, CCL2, IL18, GATA3, RBP4, CD79A
2uveitis31.2CXCR3, CCL2, LTA
3systemic lupus erythematosus31.2FCGR2A
4purpura31.2CD79A
5lupus erythematosus31.1APOH, IL18, CD79A, CD40LG
6glomerulonephritis30.9LRP2, FCGR2A, CCL2, COL4A5, RBP4, CD79A
7alport syndrome30.8COL4A5, CD79A
8proteinuria30.8LRP2, APOH, CCL2, COL4A5, RBP4, CD79A
9vasculitis30.7APOH, CCL2, CD79A, CD40LG
10hepatitis30.6LTA, CD40LG, IL18
11tuberculosis30.5CD79A, IL18, CXCR3
12proliferative glomerulonephritis30.5CD79A, CCL2, CXCR3
13arthritis30.3FCGR2A, FCGR3A, CXCR3, CCL2, IL18, LTA
14acute poststreptococcal glomerulonephritis30.3CD79A
15primary biliary cirrhosis30.2CD79A, CD40LG, LTA
16dermatitis30.2CXCR3, IL18, CD79A
17eosinophilia30.2CD79A, GATA3, IL18
18connective tissue disease30.1APOH, CCL2, CD79A, CD40LG
19leukemia30.1CXCR3, RBP4, CD79A, CD40LG, LTA
20chronic lymphocytic leukemia30.1CXCR3, CD40LG, LTA
21focal segmental glomerulosclerosis30.1CD79A, RBP4
22lipoid nephrosis30.1CCL2, CD79A
23autoimmune hemolytic anemia30.1CD79A, CD40LG
24glomerulosclerosis30.1CD79A, COL4A5, CCL2
25hepatitis c30.1CD40LG, IL18, CXCR3
26influenza30.0LTA, CD79A, CXCR3
27thrombocytopenia30.0APOH, FCGR2A, FCGR3A, CD79A, CD40LG
28pneumonia30.0CCL2, RBP4, CD79A
29cryoglobulinemia30.0CD40LG, CD79A, APOH
30antiphospholipid syndrome30.0APOH, CD79A, CD40LG
31iga glomerulonephritis29.9CCL2, CD79A, CD40LG
32skin disease29.9CXCR3, IL18, CD79A
33ulcerative colitis29.9LTA, CD79A, IL18, CXCR3
34rheumatoid arthritis29.9LRP2, APOH, LTA, CD40LG, CD79A, GATA3
35q fever29.8CD79A
36agammaglobulinemia29.7CD79A, CD40LG
37interstitial lung disease29.7CD79A, CCL2
38tonsillitis29.7LTA, CD79A
39common variable immunodeficiency29.7CD79A, CD40LG
40graves' disease29.7LRP2, CXCR3, LTA
41behcet's disease29.7LRP2, APOH, IL18, LTA
42rheumatic disease29.7APOH, FCGR2A, CXCR3, IL18, CD40LG
43atherosclerosis29.6LRP2, APOH, FCGR2A, CXCR3, CCL2, IL18
44interstitial nephritis11.2
45tubulointerstitial nephritis and uveitis10.8
46henoch-schoenlein purpura10.5
47megalocytic interstitial nephritis10.5
48nephrotic syndrome10.4
49nephrosis10.4
50fanconi syndrome10.4

Graphical network of the top 20 diseases related to Nephritis:



Diseases related to nephritis

Symptoms for Nephritis

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Drugs & Therapeutics for Nephritis

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Drug clinical trials:

Search ClinicalTrials for Nephritis

Search NIH Clinical Center for Nephritis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Nephritis

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Anatomical Context for Nephritis

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MalaCards organs/tissues related to Nephritis:

33
Kidney, T cells, Monocytes, B cells, Neutrophil, Endothelial, Bone, Liver, Skin, Thyroid, Bone marrow, Lung, Testes, Heart, Smooth muscle, Myeloid, Eye, Whole blood, Brain, Pancreas, Prostate, Tonsil

Animal Models for Nephritis or affiliated genes

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MGI Mouse Phenotypes related to Nephritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3LRP2, CXCR3, COL4A5, GATA3, CD79A, CD40LG
2MP:00053917.9LRP2, CCL2, IL18, GATA3, RBP4, LTA
3MP:00053907.6LRP2, FCGR2A, FCGR3A, CCL2, GATA3, CD40LG
4MP:00053847.6CXCR3, CCL2, IL18, GATA3, RBP4, CD79A
5MP:00053857.4CXCR3, CCL2, IL18, COL4A5, GATA3, RBP4
6MP:00053977.1FCGR2A, FCGR3A, CXCR3, CCL2, IL18, GATA3
7MP:00053876.9CCL2, CXCR3, FCGR3A, FCGR2A, IL18, COL4A5
8MP:00107686.8LRP2, APOH, FCGR2A, CXCR3, CCL2, IL18
9MP:00053766.4LTA, LRP2, APOH, FCGR3A, CXCR3, CCL2

Publications for Nephritis

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Articles related to Nephritis:

(show top 50)    (show all 1977)
idTitleAuthorsYear
1
Clinicopathological correlation in asian patients with biopsy-proven lupus nephritis. (25874130)
2015
2
Tubulointerstitial nephritis complicating IVIG therapy for X-linked agammaglobulinemia. (25005715)
2014
3
Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis with poor kidney function: a subgroup analysis of the Aspreva Lupus Management Study. (23375819)
2013
4
Varenicline induced acute interstitial nephritis in the setting of idiopathic membranous glomerulonephritis. (24215355)
2013
5
Cefpodoxime proxetil-related hemolysis and acute interstitial nephritis. (23845192)
2013
6
Long- and short-term treatment with imatinib attenuates the development of chronic kidney disease in experimental anti-glomerular basement membrane nephritis. (23045430)
2013
7
Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. (23896866)
2013
8
Serial non-invasive assessment of antibody induced nephritis in mice using positron emission tomography. (23460853)
2013
9
Survival analysis and causes of mortality in patients with lupus nephritis. (22523116)
2012
10
The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis. (22900150)
2012
11
Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis. (22128082)
2012
12
Long-term outcome of lupus nephritis in Asian Indians. (22232126)
2012
13
Herpes virus infection associated with interstitial nephritis in a beaked whale (Mesoplodon densirostris). (23237059)
2012
14
Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus. (21163672)
2011
15
The role of cytokines as biomarkers in systemic lupus erythematosus and lupus nephritis. (21372259)
2011
16
Predictive value of remission status after 6A months induction therapy in patients with proliferative lupus nephritis: a retrospective analysis. (21594768)
2011
17
Acute interstitial nephritis. (20336051)
2010
18
The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans. (20523037)
2010
19
Estimation of monocyte-chemoattractantprotein-1 (Mcp-1) level in patients with lupus nephritis. (20374368)
2009
20
C/EBP-beta modulates transcription of tubulointerstitial nephritis antigen in obstructive uropathy. (19297554)
2009
21
Relationship between integrin-linked kinase expression and renal glomerular damage in children with Henoch-Schnlein purpura nephritis]. (20113654)
2009
22
Acute Tubular Necrosis and Interstitial Nephritis during Pemetrexed Therapy. (20740145)
2009
23
Is tubulointerstitial nephritis and uveitis syndrome associated with IgG4-related systemic disease? (18199112)
2008
24
A case report of adenovirus-related acute interstitial nephritis in a patient with AIDS. (18155541)
2008
25
Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis. (17530720)
2007
26
Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis. (16461436)
2006
27
Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosus. (16868980)
2006
28
IgA nephritis: ACE inhibitors, steroids, both or neither? (16980324)
2006
29
End-stage renal failure as a complication of acute tubulo-interstitial nephritis. (17642799)
2005
30
C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist. (16052609)
2005
31
Mesangial cell Fas ligand: upregulation in human lupus nephritis and NF-kappaB-mediated expression in cultured human mesangial cells. (15480896)
2004
32
Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis. (15119544)
2004
33
Thrombotic thrombocytopenic purpura complicating SjAPgren's syndrome with crescentic glomerulonephritis and membranous nephritis. (17143670)
2004
34
Pathogenesis of acute viral disease induced in fish by carp interstitial nephritis and gill necrosis virus. (15308746)
2004
35
Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. (12556395)
2003
36
Antiphospholipid antibodies in patients with lupus nephritis. (14575283)
2003
37
Combining lisinopril and l-arginine slows disease progression and reduces endothelin-1 in passive Heymann nephritis. (12911535)
2003
38
Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. (12115187)
2002
39
Isolated sarcoid granulomatous interstitial nephritis: review of five cases at one center. (11334315)
2001
40
Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid. (11316248)
2001
41
Wegener's granulomatosis presenting as acute suppurative interstitial nephritis. (11577128)
2001
42
Anuric acute renal failure secondary to megalocytic interstitial nephritis in a patient with Behcet's disease. (11140812)
2000
43
Increased expression of cytoplasmic tail-containing form of gp600/megalin in active Heymann nephritis. (11004703)
2000
44
Association of anticardiolipin antibodies with intraglomerular thrombi and renal dysfunction in lupus nephritis. (9709458)
1998
45
The syndrome of lung hemorrhage and nephritis is usually an ANCA-associated condition. (8607730)
1996
46
Autosomal recessive Alport syndrome: mutation in the COL4A3 gene in a woman with Alport syndrome and posttransplant antiglomerular basement membrane nephritis. (7780062)
1995
47
Heymann nephritis revisited--new insights into the pathogenesis of experimental membranous glomerulonephritis. (8252799)
1993
48
Significance of anticardiolipin and antiendothelial cell antibodies in the nephritis of lupus. (1458929)
1992
49
Transient arthritis with positive tests for rheumatoid factor as presenting sign of shunt nephritis. (2015013)
1991
50
Anti-cardiolipin antibody and renal microthrombi in lupus nephritis]. (1767341)
1991

Variations for Nephritis

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Expression for genes affiliated with Nephritis

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Search GEO for disease gene expression data for Nephritis.

Pathways for genes affiliated with Nephritis

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Compounds for genes affiliated with Nephritis

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Compounds related to Nephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1gluten459.9APOH, CD79A, IL18
2natalizumab45 1310.7FCGR2A, IL18, FCGR3A
3adalimumab45 51 1311.7CD79A, FCGR3A, FCGR2A
4tuberculin459.5CD40LG, IL18, CD79A
5daclizumab45 1310.5FCGR2A, FCGR3A, CD40LG
6sulfolipid i459.5CD79A, CD40LG
7alemtuzumab45 1310.5FCGR3A, CD40LG, FCGR2A
8valine459.4COL4A5, FCGR3A, APOH, FCGR2A, RBP4
9lipoteichoic acid459.3APOH, IL18, LTA, CCL2
10il 10459.2LTA, CCL2, CXCR3, IL18
11abciximab45 1310.2CD40LG, FCGR3A, FCGR2A
12il-12459.2IL18, CCL2, CD40LG
13mannose459.2CD79A, FCGR3A, LTA, APOH, FCGR2A
14prednisolone45 30 1311.1LTA, IL18, FCGR2A, APOH, CD79A
15infliximab45 51 1311.1LTA, CXCR3, FCGR2A, APOH, IL18
16mycophenolate mofetil45 51 1311.1LTA, CD79A, CD40LG, IL18
17rituximab45 51 1311.1FCGR3A, FCGR2A, CD40LG, CD79A, APOH
18vitamin b12459.1CCL2, LRP2, APOH, CD79A, CD40LG
19methotrexate51 45 1311.1CD79A, GATA3, IL18, FCGR3A, APOH
20neopterin459.0IL18, CD79A, CD40LG, LTA
21fmlp459.0CXCR3, FCGR2A, FCGR3A, LTA, CCL2
22thyroxine45 2610.0LTA, LRP2, RBP4, CD79A, CD40LG
23folate458.9LRP2, IL18, CD79A, CD40LG, RBP4, APOH
24heparin45 30 26 1311.8APOH, CD79A, FCGR2A, CXCR3, CD40LG, LRP2
25etanercept45 51 1310.8FCGR2A, LTA, IL18, CXCR3, FCGR3A, APOH
26polysaccharide458.7CD79A, FCGR2A, CCL2, IL18, CD40LG
27allergens458.7GATA3, IL18, LRP2, CXCR3, CD79A, CD40LG
28fibrinogen458.7APOH, CCL2, CD79A, IL18, CD40LG
29histamine45 30 2610.6CD79A, CD40LG, IL18, CCL2, CXCR3, FCGR2A
30ivig458.6FCGR2A, CD40LG, LTA, CD79A, APOH, FCGR3A
31herbimycin a45 619.6LTA, FCGR3A, CD40LG, CCL2
32rantes458.6CD40LG, CXCR3, CCL2, IL18, LTA
33lactate458.5LTA, CD40LG, CD79A, RBP4, IL18, APOH
34progesterone45 30 61 26 1312.4IL18, CXCR3, APOH, GATA3, RBP4, LTA
35tgf beta1458.4GATA3, CCL2, IL18, LTA
36endotoxin458.4LTA, APOH, CD40LG, IL18, CCL2, CXCR3
37pge2458.4CCL2, IL18, CD79A, CD40LG, LTA, CXCR3
38creatinine458.4CD79A, CD40LG, APOH, CXCR3, CCL2, RBP4
39steroid458.2IL18, LTA, CD79A, RBP4, GATA3, CXCR3
40oxygen45 269.1FCGR2A, APOH, FCGR3A, CXCR3, CCL2, IL18
41vegf458.0CD40LG, APOH, LTA, CCL2, CD79A, IL18
42retinoic acid45 269.0LTA, RBP4, GATA3, CD40LG, CD79A, IL18
43cysteine458.0IL18, COL4A5, RBP4, CD79A, TINAG, TINAGL1
44lipid457.9RBP4, APOH, LRP2, FCGR2A, CCL2, IL18
45cholesterol45 30 26 1310.9APOH, LTA, IL18, LRP2, CXCR3, RBP4
46arginine457.8CCL2, COL4A5, APOH, CD79A, CD40LG, CXCR3
47estrogen457.8RBP4, IL18, CXCR3, CD79A, CD40LG, LTA
48dexamethasone45 51 30 1310.7CXCR3, IL18, CCL2, GATA3, RBP4, CD79A
49serine457.6LRP2, CD40LG, RBP4, COL4A5, IL18, CCL2
50calcium45 51 26 1310.2GATA3, LRP2, APOH, RBP4, IL18, FCGR2A

GO Terms for genes affiliated with Nephritis

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Cellular components related to Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.7FCGR3A, CXCR3, CD79A, CD40LG
2extracellular regionGO:00055768.0RBP4, COL4A5, IL18, CCL2, TINAGL1, FCGR3A
3extracellular spaceGO:00056157.0LTA, CD40LG, RBP4, IL18, CCL2, TINAGL1

Biological processes related to Nephritis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:00600659.9RBP4, GATA3
2negative regulation of endothelial cell proliferationGO:00019379.9CXCR3, APOH
3lipopolysaccharide-mediated signaling pathwayGO:00316639.7IL18, CCL2
4negative regulation of angiogenesisGO:00165259.7CCL2, CXCR3, APOH
5response to gamma radiationGO:00103329.5CCL2, GATA3
6response to ethanolGO:00454719.5RBP4, GATA3, CCL2
7angiogenesisGO:00015259.4IL18, CCL2, CXCR3
8B cell proliferationGO:00421009.3CD40LG, CD79A
9humoral immune responseGO:00069599.3LTA, GATA3, CCL2
10inflammatory responseGO:00069549.0CXCR3, CCL2, IL18, CD40LG
11immune responseGO:00069558.8FCGR3A, TINAGL1, TINAG, IL18

Molecular functions related to Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:00198649.8FCGR3A, FCGR2A
2polysaccharide bindingGO:00302479.4TINAG, TINAGL1
3tumor necrosis factor receptor bindingGO:00051649.3LTA, CD40LG
4cytokine activityGO:00051258.7LTA, CD40LG, IL18

Products for genes affiliated with Nephritis

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Sources for Nephritis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet