Summaries for Nephritis

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Wikipedia:63 Nephritis is inflammation of the kidneys and may involve the glomeruli, tubules, or interstitial tissue... more...

MalaCards based summary: Nephritis is related to systemic lupus erythematosus and purpura. An important gene associated with Nephritis is TINAG (tubulointerstitial nephritis antigen), and among its related pathways are Tuberculosis and B Cell Receptor Signaling Pathway. The drug magnesium sulfate and the compounds gluten and natalizumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and monocytes, and related mouse phenotypes are renal/urinary system and vision/eye.

Aliases & Classifications for Nephritis

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Sources:
11DISEASES, 43Novoseek, 60UMLS
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Nephritis, Aliases & Descriptions:

Name: Nephritis 11 43 60


Related Diseases for Nephritis

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Diseases related to Nephritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 397)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus31.9FCGR2A
2purpura31.9CD79A
3alport syndrome31.4COL4A5, CD79A
4uveitis31.1CXCR3, CCL2, LTA
5lupus erythematosus31.1APOH, IL18, CD79A, CD40LG
6acute poststreptococcal glomerulonephritis31.0CD79A
7tuberculosis30.8CD79A, IL18, CXCR3
8proliferative glomerulonephritis30.8CD79A, CCL2, CXCR3
9vasculitis30.6APOH, CCL2, CD79A, CD40LG
10q fever30.5CD79A
11lipoid nephrosis30.5CCL2, CD79A
12autoimmune hemolytic anemia30.5CD79A, CD40LG
13glomerulonephritis30.5LRP2, FCGR2A, CCL2, COL4A5, RBP4, CD79A
14focal segmental glomerulosclerosis30.5CD79A, RBP4
15dermatitis30.4CXCR3, IL18, CD79A
16glomerulosclerosis30.4CD79A, COL4A5, CCL2
17proteinuria30.3LRP2, APOH, CCL2, COL4A5, RBP4, CD79A
18eosinophilia30.3CD79A, GATA3, IL18
19pneumonia30.2CCL2, RBP4, CD79A
20cryoglobulinemia30.2CD40LG, CD79A, APOH
21antiphospholipid syndrome30.2APOH, CD79A, CD40LG
22primary biliary cirrhosis30.2CD79A, CD40LG, LTA
23hepatitis c30.2CD40LG, IL18, CXCR3
24hepatitis30.1LTA, CD40LG, IL18
25connective tissue disease30.1APOH, CCL2, CD79A, CD40LG
26iga glomerulonephritis30.1CCL2, CD79A, CD40LG
27agammaglobulinemia30.1CD79A, CD40LG
28skin disease30.0CXCR3, IL18, CD79A
29interstitial lung disease29.9CD79A, CCL2
30chronic lymphocytic leukemia29.9CXCR3, CD40LG, LTA
31tonsillitis29.9LTA, CD79A
32influenza29.9LTA, CD79A, CXCR3
33thrombocytopenia29.8APOH, FCGR2A, FCGR3A, CD79A, CD40LG
34graves' disease29.7LRP2, CXCR3, LTA
35ulcerative colitis29.7LTA, CD79A, IL18, CXCR3
36lupus nephritis29.7CXCR3, CCL2, IL18, GATA3, RBP4, CD79A
37common variable immunodeficiency29.7CD79A, CD40LG
38arthritis29.6FCGR2A, FCGR3A, CXCR3, CCL2, IL18, LTA
39behcet's disease29.5LRP2, APOH, IL18, LTA
40leukemia29.4CXCR3, RBP4, CD79A, CD40LG, LTA
41rheumatic disease29.4APOH, FCGR2A, CXCR3, IL18, CD40LG
42atherosclerosis28.7LRP2, APOH, FCGR2A, CXCR3, CCL2, IL18
43rheumatoid arthritis28.0LRP2, APOH, LTA, CD40LG, CD79A, GATA3
44interstitial nephritis11.2
45tubulointerstitial nephritis and uveitis10.8
46chickenpox10.5CD79A
47macroglobulinemia10.5CD79A
48cryptosporidiosis10.5CD79A
49megalocytic interstitial nephritis10.5
50henoch-schoenlein purpura10.5

Graphical network of the top 20 diseases related to Nephritis:



Diseases related to nephritis

Symptoms for Nephritis

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Drugs & Therapeutics for Nephritis

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Drug clinical trials:

Search ClinicalTrials for Nephritis

Search NIH Clinical Center for Nephritis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Nephritis

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Anatomical Context for Nephritis

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MalaCards organs/tissues related to Nephritis:

31
Kidney, T cells, Monocytes, B cells, Neutrophil, Endothelial, Bone, Liver, Skin, Thyroid, Bone marrow, Lung, Testes, Heart, Smooth muscle, Myeloid, Eye, Whole blood, Brain, Pancreas, Prostate, Tonsil

Animal Models for Nephritis or affiliated genes

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MGI Mouse Phenotypes related to Nephritis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3LRP2, CXCR3, COL4A5, GATA3, CD79A, CD40LG
2MP:00053917.9LRP2, CCL2, IL18, GATA3, RBP4, LTA
3MP:00053907.6LRP2, FCGR2A, FCGR3A, CCL2, GATA3, CD40LG
4MP:00053847.6CXCR3, CCL2, IL18, GATA3, RBP4, CD79A
5MP:00053857.4CXCR3, CCL2, IL18, COL4A5, GATA3, RBP4
6MP:00053977.1FCGR2A, FCGR3A, CXCR3, CCL2, IL18, GATA3
7MP:00053876.9CCL2, CXCR3, FCGR3A, FCGR2A, IL18, COL4A5
8MP:00107686.8LRP2, APOH, FCGR2A, CXCR3, CCL2, IL18
9MP:00053766.4LTA, LRP2, APOH, FCGR3A, CXCR3, CCL2

Publications for Nephritis

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Articles related to Nephritis:

(show top 50)    (show all 1977)
idTitleAuthorsYear
1
Clinicopathological correlation in asian patients with biopsy-proven lupus nephritis. (25874130)
2015
2
Tubulointerstitial nephritis complicating IVIG therapy for X-linked agammaglobulinemia. (25005715)
2014
3
Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis with poor kidney function: a subgroup analysis of the Aspreva Lupus Management Study. (23375819)
2013
4
Varenicline induced acute interstitial nephritis in the setting of idiopathic membranous glomerulonephritis. (24215355)
2013
5
Cefpodoxime proxetil-related hemolysis and acute interstitial nephritis. (23845192)
2013
6
Long- and short-term treatment with imatinib attenuates the development of chronic kidney disease in experimental anti-glomerular basement membrane nephritis. (23045430)
2013
7
Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. (23896866)
2013
8
Serial non-invasive assessment of antibody induced nephritis in mice using positron emission tomography. (23460853)
2013
9
Survival analysis and causes of mortality in patients with lupus nephritis. (22523116)
2012
10
The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis. (22900150)
2012
11
Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis. (22128082)
2012
12
Long-term outcome of lupus nephritis in Asian Indians. (22232126)
2012
13
Herpes virus infection associated with interstitial nephritis in a beaked whale (Mesoplodon densirostris). (23237059)
2012
14
Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus. (21163672)
2011
15
The role of cytokines as biomarkers in systemic lupus erythematosus and lupus nephritis. (21372259)
2011
16
Predictive value of remission status after 6A months induction therapy in patients with proliferative lupus nephritis: a retrospective analysis. (21594768)
2011
17
Acute interstitial nephritis. (20336051)
2010
18
The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans. (20523037)
2010
19
Estimation of monocyte-chemoattractantprotein-1 (Mcp-1) level in patients with lupus nephritis. (20374368)
2009
20
C/EBP-beta modulates transcription of tubulointerstitial nephritis antigen in obstructive uropathy. (19297554)
2009
21
Relationship between integrin-linked kinase expression and renal glomerular damage in children with Henoch-Schnlein purpura nephritis]. (20113654)
2009
22
Acute Tubular Necrosis and Interstitial Nephritis during Pemetrexed Therapy. (20740145)
2009
23
Is tubulointerstitial nephritis and uveitis syndrome associated with IgG4-related systemic disease? (18199112)
2008
24
A case report of adenovirus-related acute interstitial nephritis in a patient with AIDS. (18155541)
2008
25
Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis. (17530720)
2007
26
Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis. (16461436)
2006
27
Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosus. (16868980)
2006
28
IgA nephritis: ACE inhibitors, steroids, both or neither? (16980324)
2006
29
End-stage renal failure as a complication of acute tubulo-interstitial nephritis. (17642799)
2005
30
C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist. (16052609)
2005
31
Mesangial cell Fas ligand: upregulation in human lupus nephritis and NF-kappaB-mediated expression in cultured human mesangial cells. (15480896)
2004
32
Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis. (15119544)
2004
33
Thrombotic thrombocytopenic purpura complicating SjAPgren's syndrome with crescentic glomerulonephritis and membranous nephritis. (17143670)
2004
34
Pathogenesis of acute viral disease induced in fish by carp interstitial nephritis and gill necrosis virus. (15308746)
2004
35
Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. (12556395)
2003
36
Antiphospholipid antibodies in patients with lupus nephritis. (14575283)
2003
37
Combining lisinopril and l-arginine slows disease progression and reduces endothelin-1 in passive Heymann nephritis. (12911535)
2003
38
Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. (12115187)
2002
39
Isolated sarcoid granulomatous interstitial nephritis: review of five cases at one center. (11334315)
2001
40
Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid. (11316248)
2001
41
Wegener's granulomatosis presenting as acute suppurative interstitial nephritis. (11577128)
2001
42
Anuric acute renal failure secondary to megalocytic interstitial nephritis in a patient with Behcet's disease. (11140812)
2000
43
Increased expression of cytoplasmic tail-containing form of gp600/megalin in active Heymann nephritis. (11004703)
2000
44
Association of anticardiolipin antibodies with intraglomerular thrombi and renal dysfunction in lupus nephritis. (9709458)
1998
45
The syndrome of lung hemorrhage and nephritis is usually an ANCA-associated condition. (8607730)
1996
46
Autosomal recessive Alport syndrome: mutation in the COL4A3 gene in a woman with Alport syndrome and posttransplant antiglomerular basement membrane nephritis. (7780062)
1995
47
Heymann nephritis revisited--new insights into the pathogenesis of experimental membranous glomerulonephritis. (8252799)
1993
48
Significance of anticardiolipin and antiendothelial cell antibodies in the nephritis of lupus. (1458929)
1992
49
Transient arthritis with positive tests for rheumatoid factor as presenting sign of shunt nephritis. (2015013)
1991
50
Anti-cardiolipin antibody and renal microthrombi in lupus nephritis]. (1767341)
1991

Variations for Nephritis

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Expression for genes affiliated with Nephritis

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Search GEO for disease gene expression data for Nephritis.

Pathways for genes affiliated with Nephritis

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Compounds for genes affiliated with Nephritis

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Compounds related to Nephritis according to GeneCards Suite gene sharing:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1gluten439.9APOH, CD79A, IL18
2natalizumab43 1210.7FCGR2A, IL18, FCGR3A
3adalimumab43 49 1211.7CD79A, FCGR3A, FCGR2A
4tuberculin439.5CD40LG, IL18, CD79A
5daclizumab43 1210.5FCGR2A, FCGR3A, CD40LG
6sulfolipid i439.5CD79A, CD40LG
7alemtuzumab43 1210.5FCGR3A, CD40LG, FCGR2A
8valine439.4COL4A5, FCGR3A, APOH, FCGR2A, RBP4
9lipoteichoic acid439.3APOH, IL18, LTA, CCL2
10il 10439.2LTA, CCL2, CXCR3, IL18
11abciximab43 1210.2CD40LG, FCGR3A, FCGR2A
12il-12439.2IL18, CCL2, CD40LG
13mannose439.2CD79A, FCGR3A, LTA, APOH, FCGR2A
14prednisolone43 28 1211.1LTA, IL18, FCGR2A, APOH, CD79A
15infliximab43 49 1211.1LTA, CXCR3, FCGR2A, APOH, IL18
16mycophenolate mofetil43 49 1211.1LTA, CD79A, CD40LG, IL18
17rituximab43 49 1211.1FCGR3A, FCGR2A, CD40LG, CD79A, APOH
18vitamin b12439.1CCL2, LRP2, APOH, CD79A, CD40LG
19methotrexate49 43 1211.1CD79A, GATA3, IL18, FCGR3A, APOH
20neopterin439.0IL18, CD79A, CD40LG, LTA
21fmlp439.0CXCR3, FCGR2A, FCGR3A, LTA, CCL2
22thyroxine43 2410.0LTA, LRP2, RBP4, CD79A, CD40LG
23folate438.9LRP2, IL18, CD79A, CD40LG, RBP4, APOH
24heparin43 28 24 1211.8APOH, CD79A, FCGR2A, CXCR3, CD40LG, LRP2
25etanercept43 49 1210.8FCGR2A, LTA, IL18, CXCR3, FCGR3A, APOH
26polysaccharide438.7CD79A, FCGR2A, CCL2, IL18, CD40LG
27allergens438.7GATA3, IL18, LRP2, CXCR3, CD79A, CD40LG
28fibrinogen438.7APOH, CCL2, CD79A, IL18, CD40LG
29histamine43 28 2410.6CD79A, CD40LG, IL18, CCL2, CXCR3, FCGR2A
30ivig438.6FCGR2A, CD40LG, LTA, CD79A, APOH, FCGR3A
31herbimycin a43 599.6LTA, FCGR3A, CD40LG, CCL2
32rantes438.6CD40LG, CXCR3, CCL2, IL18, LTA
33lactate438.5LTA, CD40LG, CD79A, RBP4, IL18, APOH
34progesterone43 28 59 24 1212.4IL18, CXCR3, APOH, GATA3, RBP4, LTA
35tgf beta1438.4GATA3, CCL2, IL18, LTA
36endotoxin438.4LTA, APOH, CD40LG, IL18, CCL2, CXCR3
37pge2438.4CCL2, IL18, CD79A, CD40LG, LTA, CXCR3
38creatinine438.4CD79A, CD40LG, APOH, CXCR3, CCL2, RBP4
39steroid438.2IL18, LTA, CD79A, RBP4, GATA3, CXCR3
40oxygen43 249.1FCGR2A, APOH, FCGR3A, CXCR3, CCL2, IL18
41vegf438.0CD40LG, APOH, LTA, CCL2, CD79A, IL18
42retinoic acid43 249.0LTA, RBP4, GATA3, CD40LG, CD79A, IL18
43cysteine438.0IL18, COL4A5, RBP4, CD79A, TINAG, TINAGL1
44lipid437.9RBP4, APOH, LRP2, FCGR2A, CCL2, IL18
45cholesterol43 28 24 1210.9APOH, LTA, IL18, LRP2, CXCR3, RBP4
46arginine437.8CCL2, COL4A5, APOH, CD79A, CD40LG, CXCR3
47estrogen437.8RBP4, IL18, CXCR3, CD79A, CD40LG, LTA
48dexamethasone43 49 28 1210.7CXCR3, IL18, CCL2, GATA3, RBP4, CD79A
49serine437.6LRP2, CD40LG, RBP4, COL4A5, IL18, CCL2
50calcium43 49 24 1210.2GATA3, LRP2, APOH, RBP4, IL18, FCGR2A

GO Terms for genes affiliated with Nephritis

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Cellular components related to Nephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098978.7FCGR3A, CXCR3, CD79A, CD40LG
2extracellular regionGO:00055768.0RBP4, COL4A5, IL18, CCL2, TINAGL1, FCGR3A
3extracellular spaceGO:00056157.0LTA, CD40LG, RBP4, IL18, CCL2, TINAGL1

Biological processes related to Nephritis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:00600659.9RBP4, GATA3
2negative regulation of endothelial cell proliferationGO:00019379.9CXCR3, APOH
3lipopolysaccharide-mediated signaling pathwayGO:00316639.7IL18, CCL2
4negative regulation of angiogenesisGO:00165259.7CCL2, CXCR3, APOH
5response to gamma radiationGO:00103329.5CCL2, GATA3
6response to ethanolGO:00454719.5RBP4, GATA3, CCL2
7angiogenesisGO:00015259.4IL18, CCL2, CXCR3
8B cell proliferationGO:00421009.3CD40LG, CD79A
9humoral immune responseGO:00069599.3LTA, GATA3, CCL2
10inflammatory responseGO:00069549.0CXCR3, CCL2, IL18, CD40LG
11immune responseGO:00069558.8FCGR3A, TINAGL1, TINAG, IL18

Molecular functions related to Nephritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:00198649.8FCGR3A, FCGR2A
2polysaccharide bindingGO:00302479.4TINAG, TINAGL1
3tumor necrosis factor receptor bindingGO:00051649.3LTA, CD40LG
4cytokine activityGO:00051258.7LTA, CD40LG, IL18

Products for genes affiliated with Nephritis

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Sources for Nephritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet