Nephritis malady

Wikipedia: Nephritis is inflammation of the nephrons in the kidneys. Nephritis comes from Latin, from Ancient Greek...⁴⁴ more...

MalaCards: Nephritis is related to lupus nephritis and interstitial nephritis. An important gene associated with Nephritis is TINAGL1 (tubulointerstitial nephritis antigen-like 1), and among its related pathways are Systemic lupus erythematosus and Staphylococcus aureus infection. The drugs magnesium (as sulfate) and magnesium sulfate and the compounds glucose and rituximab have been mentioned in the context of this disorder. Affiliated tissues include kidney, whole blood and smooth muscle, and related mouse phenotypes are hematopoietic system and growth/size.

nephritis 8 32 43

Diseases related to nephritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 979)

id	Related Disease	Score	Top Affiliating Genes
1	lupus nephritis	48.8	PDCD1, PDCD5, VWF, PCNA, RBP4, SELE
2	interstitial nephritis	35.9	REN, RBP4, B2M, ATP4A, ATP12A, INVS
3	systemic lupus erythematosus	35.2	PDCD1, IRF5, FCGR2B, FASLG, MBL2, C4A
4	alport syndrome	33.7	CD79A, MMP3, COL4A5, COL4A3, COL4A4, MYH9
5	purpura	31.9	VWF, SELE, SELP, SERPINE1, VEGFA, VCAM1
6	lupus erythematosus	31.8	LRP2, PDCD1, VWF, PCNA, RBP4, SELE
7	henoch-schoenlein purpura	31.2	VCAM1, MX1, MPO, CD79A, ICAM1, RNASE3
8	berger disease	30.9	SERPINB7, NAGLU, BMP6, CD79A, CD40LG, MBL2
9	glomerulopathy	30.7	LRP2, REN, VWF, SELE, SELP, NAGLU
10	proteinuria	30.2	LRP2, REN, VWF, RBP4, SELP, SERPINB7
11	crohn's disease	30.0	LCN2, MPO, CD80, IL10, IL11, IL13
12	rheumatoid arthritis	29.9	IL1R1, IL1RN, MBL2, HLA-DRB1, TNFRSF1A, CRP
13	immunodeficiency	29.2	PDCD1, BMP6, PARP1, CIITA, CD209, CD79A
14	uveitis	29.1	SELE, SERPINA1, VEGFA, BMP6, LCN2, S100A8
15	primary biliary cirrhosis	29.0	PDCD1, CIITA, CD79A, CD40LG, MBL2, ENO1
16	malignant hypertension	28.9	REN, VWF, APOH, EDN1, ACE, AGT
17	arthritis	28.9	SERPINA1, MMP3, IL17A, IL6, IL8, TNF
18	systemic lupus erythematosus, association with	28.9	PDCD1, SERPINE1, CD40LG, CD274, ITGAM, IRF5
19	fabry disease	28.8	VWF, SELE, VCAM1, UMOD, LCN2, S100A8
20	castleman's disease	28.5	VEGFA, B2M, IL10, IL6, IFNA1, F3
21	hepatitis	28.4	RBP4, SELP, SERPINA1, XDH, FASLG, FAS
22	anterior uveitis	28.4	LCN2, IL10, IL1RN, IL6, IL8, FASLG
23	bullous pemphigoid	28.2	CIITA, CD79A, IL13, CCL5, HLA-DQB1, TNFSF13B
24	glomerulonephritis	28.2	LRP2, LRPAP1, REN, VWF, PCNA, RBP4
25	nephrotic syndrome	28.2	LRP2, REN, VWF, PCNA, RBP4, SELE
26	vasculitis	28.1	PDCD1, REN, VWF, SELE, SELP, SERPINA1
27	graft versus host disease	28.1	IL10, IL11, IL13, IL18, IL1R1, IL1RAPL2
28	nephropathy	27.9	LRP2, LRPAP1, PDCD1, REN, VWF, PCNA
29	alpha 1-antitrypsin deficiency	27.7	SERPINA1, SERPINE1, VEGFA, BMP6, MPO, MMP12
30	antiphospholipid syndrome	27.7	VWF, SELE, SELP, SERPINE1, VEGFA, VCAM1
31	fanconi syndrome	27.6	LRP2, NAGLU, ALB, CTNS, TF, OGDH
32	hepatitis c	27.6	SERPINA1, CIITA, MX1, CD40LG, IL10, IL18
33	retinol binding protein	27.4	RBP4, NAGLU, LPA, LEP, LCN2, XDH
34	end stage renal failure	27.0	SELP, VEGFA, UMOD, LEP, CD79A, FN1
35	hearing loss	26.4	LRP2, SERPINE1, PAX2, PATZ1, XDH, CD36
36	pyelonephritis	25.6	NAGLU, UMOD, XDH, B2M, CD79A, CD40LG
37	amyloidosis	25.5	VWF, RBP4, LPA, B2M, CD79A, CD40LG
38	hypertension	25.0	REN, VWF, PCNA, RBP4, SELE, SELP
39	fibrosis	24.3	REN, VWF, PCNA, RBP4, SELE, SELP
40	pneumonia	23.7	RBP4, SELE, SERPINA1, SERPINE1, NAGLU, VEGFA
41	diabetes mellitus	21.3	PDCD1, REN, VWF, RBP4, SELE, SELP
42	iga glomerulonephritis	15.0	SELE, SERPINB7, SERPINA1, NAGLU, BMP6, CFP
43	cutaneous lupus erythematosus	15.0	SELE, MX1, CD79A, CD40LG, IL10, IL17A
44	polymyositis	14.9	VWF, SELE, VEGFA, VCAM1, S100A8, CD86
45	addison's disease	14.8	PDCD1, REN, CD79A, CD274, FCGR2A, FCGR3A
46	hepatitis b	14.8	PDCD1, MX1, CD274, CD40, IL10, IL17A
47	microscopic polyangiitis	14.8	SELE, MPO, FCGR2A, FCGR2B, FCGR3A, FCGR3B
48	idiopathic myopathy	14.8	VCAM1, CD86, CD274, CD40, IL13, IL1R1
49	syphilis	14.8	B2M, CD209, CD79A, CD4, CD40LG, FN1
50	leptospirosis	14.7	NAGLU, CD79A, CD40LG, FN1, IL10, IL18

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 magnesium (as sulfate), magnesium sulfate

MalaCards organs/tissues related to nephritis:

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MGI Mouse Phenotypes related to nephritis:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	INF	PDCD1, PCNA, CMKLR1, PATZ1, LGALS3, LCN2
2	growth/size phenotype	MP:0005378	INF	LRP2, REN, SELE, SELP, SERPINE1, NAGLU
3	integument phenotype	MP:0010771	INF	SELP, PARP1, XDH, FST, CDKN1A, CD4
4	homeostasis/metabolism phenotype	MP:0005376	INF	LRP2, LRPAP1, REN, VWF, RBP4, SELE
5	mortality/aging	MP:0010768	INF	LRPAP1, PDCD1, REN, VWF, SELE, SELP
6	immune system phenotype	MP:0005387	INF	REN, VWF, SELP, NAGLU, PATZ1, LGALS3
7	renal/urinary system phenotype	MP:0005367	INF	LRP2, LRPAP1, PDCD1, REN, SELP, NAGLU
8	respiratory system phenotype	MP:0005388	10.9	LRP2, SELP, CMKLR1, MT2A, MT1A, FST
9	no phenotypic analysis	MP:0003012	10.8	LRP2, PCNA, VEGFA, VCAM1, PARP1, CD209
10	endocrine/exocrine gland phenotype	MP:0005379	10.7	LRP2, LRPAP1, PAX2, PATZ1, XDH, CD40LG
11	other phenotype	MP:0005395	10.4	LRPAP1, CD40LG, FN1, IL13, IL2, CCR2
12	embryogenesis phenotype	MP:0005380	10.1	PARP1, ITGA4, FLI1, FKBP4, INVS, MET
13	normal phenotype	MP:0002873	10.0	LRPAP1, REN, RBP4, SELE, VEGFA, CIITA
14	skeleton phenotype	MP:0005390	9.4	LRP2, NAGLU, VEGFA, BMP6, LGALS3, UMOD
15	reproductive system phenotype	MP:0005389	9.3	LRPAP1, REN, RBP4, VEGFA, PAX2, PATZ1
16	liver/biliary system phenotype	MP:0005370	9.0	VEGFA, MT2A, MT1A, CD36, FLI1, INVS
17	adipose tissue phenotype	MP:0005375	8.8	SERPINE1, UMOD, LEP, MTOR, XDH, CDKN1A
18	nervous system phenotype	MP:0003631	8.7	LRPAP1, PDCD1, REN, VWF, SELP, NAGLU
19	digestive/alimentary phenotype	MP:0005381	7.7	LRP2, VWF, VEGFA, LGALS3, LEP, MT2A
20	muscle phenotype	MP:0005369	7.4	PDCD1, REN, RBP4, VEGFA, LEP, MTOR
21	vision/eye phenotype	MP:0005391	6.4	LRP2, PDCD1, RBP4, SELE, SELP, NAGLU
22	cellular phenotype	MP:0005384	INF	LRP2, PDCD1, VWF, PCNA, RBP4, SELE
23	tumorigenesis	MP:0002006	INF	SERPINE1, LEP, MT2A, MT1A, B2M, CDKN1A
24	cardiovascular system phenotype	MP:0005385	INF	PDCD1, REN, VWF, RBP4, SELE, SELP
25	behavior/neurological phenotype	MP:0005386	INF	LRP2, REN, SELE, SELP, NAGLU, LEP

Articles related to nephritis:

(show top 50)    (show all 436)

id	Title	Authors	Year	Affiliating Genes
1	Elevation of human tumor necrosis factor-like weak in ducer of apoptosis in peripheral blood mononuclear cells is correlated with dis ease activity and lupus nephritis in patients with systemic lupus erythematosus . (21163672)	Liu Z.C.... Zuo X.X.	2011	TNFSF12
2	The non-muscle Myosin heavy chain 9 gene (MYH9) is no t associated with lupus nephritis in African Americans. (20523037)	Freedman B.I.... Kimberly R.P.	2010	MYH9
3	Increased urinary levels of the leukocyte adhesion mo lecules ICAM-1 and VCAM-1 in human lupus nephritis with advanced renal histolog ical changes: preliminary findings. (20714774)	Abd-Elkareem M.I.... Hussein M.R.	2010	ICAM1, VCAM1
4	Role of the Fcgamma receptor IIIA-V/F158 polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta- analysis. (20059375)	Li L.H.... Ye D.Q.	2010	FCGR3A
5	Association of the MCP-1 -2518 A/G polymorphism and n o association of its receptor CCR2 -64 V/I polymorphism with lupus nephritis. (20231199)	Malafronte P.... Woronik V.	2010	CCL2, CCR2
6	C/EBP-beta modulates transcription of tubulointerstitial nephritis antigen in obstructive uropathy. (19297554)	Xie P.... Kanwar Y.S.	2009	TINAG
7	ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai. (19286673)	Yang W.... Lau Y.L.	2009	ITGAM
8	Myeloperoxidase antineutrophil cytoplasmic antibody-a ssociated vasculitis with diffuse tubulointerstitial nephritis. (19557721)	Son D.... Yamamoto K.	2009	MPO
9	Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus. (19144150)	Li Y.... Richards H.B.	2009	FCGR1A
10	Renal interstitial cells, proteinuria and progression of lupus nephritis: new frontiers for old factors. (18539706)	Ferraccioli G.... Romano G.	2008	TGFB1, CCL3, TGIF1
11	Interleukin-20 targets renal mesangial cells and is associated with lupus nephritis. (18771958)	Li H.H.... Chang M.S.	2008	CCL2, CCL5, IL10
12	Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis. (18980674)	Reddy P.S.... O'Toole M.	2008	MTOR
13	Messenger RNA expression of podocyte-associated molecules in urinary sediment of patients with lupus nephritis. (17985404)	Wang G.... Szeto C.C.	2007	NPHS1, NPHS2, SYNPO
14	Elevated urinary VCAM-1, P-selectin, soluble TNF receptor-1, and CXC chemokine ligand 16 in multiple murine lupus strains and human lupus nephritis. (17982109)	Wu T.... Mohan C.	2007	VCAM1, CXCL16
15	In situ glomerular expression of activated NF-kappaB in human lupus nephritis and other non-proliferative proteinuric glomerulopathy. (16205945)	Zheng L.... Hsu S.I.	2006	CD40, SYNPO
16	Significance of antiphospholipid antibodies in lupus nephritis. (17044463)	Natejumnong C.... Supaporn T.	2006	APOH
17	The interplay of chemokines and dendritic cells in the pathogenesis of lupus nephritis. (16126984)	Tucci M.... Silvestris F.	2005	CCL2
18	Proliferative lupus nephritis and leukocytoclastic vasculitis during treatment with etanercept. (15801034)	Mor A.... Belmont H.M.	2005	TNF
19	Association of interleukin-10 gene -592 A/C polymorphism with the clinical and pathological diversity of lupus nephritis. (16396704)	Zhu L.J.... Li L.S.	2005	IL10
20	Apoptosis and proliferating cell nuclear antigen in lupus nephritis (class IV) and membranoproliferative glomerulonephritis. (15717643)	Kirim S.... Gonlusen G.	2005	PCNA
21	Cytokine balance in kidney tissue from lupus nephritis patients. (12730502)	Uhm W.S.... Yoo D.H.	2003	CD40LG, CD40, IL10
22	The Fc gamma RIIIA-F158 allele is a risk factor for the development of lupus nephritis: a meta-analysis. (12631364)	Karassa F.B.... Ioannidis J.P.	2003	FCGR3A
23	Antiphospholipid antibodies in patients with lupus nephritis. (14575283)	FialovA! L.... CertA-kovA! V.	2003	APOH
24	Macrophage metalloelastase as a major factor for glomerular injury in anti-glomerular basement membrane nephritis. (12626598)	Kaneko Y.... Gejyo F.	2003	MMP12
25	Identification of IgG subclasses and C-reactive protein in lupus nephritis: the relationship between the composition of immune deposits and FCgamma receptor type IIA alleles. (12571856)	Zuniga R.... Salmon J.E.	2003	FCGR2A
26	Imbalance between interleukin-6 and adrenomedullin mR NA levels in peripheral blood mononuclear cells of patients with lupus nephriti s. (11422212)	Nishitani Y.... Dohi K.	2001	IL6, ADM
27	Excessive body weight as a new independent risk factor for clinical and pathological progression in primary IgA nephritis. (11273871)	Bonnet F.... Berthoux F.	2001	CD79A
28	Anticardiolipin antibodies in South African patients with lupus nephritis: a clinical and renal pathological study. (11092990)	Naiker I.P.... Seedat Y.K.	2000	APOH
29	Interleukin-10 promoter polymorphism and lupus nephritis: comment on the article by Mok et al. (10088793)	Crawley E.... Kay R.	1999	IL10
30	Improved survival and amelioration of nephrotoxic nephritis in intercellular adhesion molecule-1 knockout mice. (9773781)	Janssen U.... Floege J.	1998	ICAM1
31	Cryosupernatant plasma exchange in the treatment of antiphospholipid antibody syndrome with lupus nephritis. (10227776)	Akioka Y.... Ito K.	1998	VWF
32	Antiphospholipid antibodies in pediatric lupus nephritis. (9041210)	Massengill S.F.... Kao K.J.	1997	CD40LG, APOH
33	Pan-nephritis (glomerulonephritis, arteriolitis, and tubulointerstitial nephritis) associated with predominant mesangial C1q deposition and hypocomplementemia: a variant type of C1q nephropathy? (8678071)	Imai H.... Nakamoto Y.	1996	CD40LG, CD79A
34	Receptors in proximal tubular epithelial cells for tubulointerstitial nephritis antigen. (8770961)	Chen Y.... Charonis A.S.	1996	TINAG
35	Passive Heymann nephritis: evidence that angiotensin-converting enzyme inhibition reduces proteinuria and retards renal structural injury. (8983642)	Zoja C.... Benigni A.	1996	TGFB1, ACE, EDN1
36	Intravenous immune globulin therapy of lupus nephritis: use of pathogenic anti-DNA-reactive IgG. (8625551)	Silvestris F.... Dammacco F.	1996	IL6
37	Henoch-Schoenlein purpura-nephritis followed by IgA-nephritis in 3 children (8720706)	Lilien M.R.... Vroom T.M.	1996	CD79A
38	Means for the inhibition of the nonimmune progression of nephritis (8577123)	Tareeva I.E.... Neverov N.I.	1995	ALB
39	Role of receptor-associated 39/45 kD protein in active Heymann nephritis. (7723231)	Huang J.... Makker S.P.	1995	LRP2, LRPAP1
40	HLA molecules and genes in primary IgA nephritis with end-stage renal failure. (7758343)	Berthoux P.... Berthoux F.C.	1995	CD79A
41	Decreased platelet counts and decreased platelet serotonin in poststreptococcal nephritis. (7723894)	Mezzano S.... Mezzano D.	1995	PF4
42	Tubulointerstitial nephritis antigen interacts with l aminin and type IV collagen and promotes cell adhesion. (8294412)	Kalfa T.A.... Charonis A.S.	1994	TINAG
43	A role for histones and ubiquitin in lupus nephritis? (7511086)	StAPckl F.... Rodriguez-Iturbe B.	1994	RPS27A
44	Intermittent intravenous treatment of lupus nephritis with cyclophosphamide: a four-year experience with twenty-four patients. (8087706)	Chu S.J.... Chang M.L.	1994	ALB
45	Anti-5S RNA/protein (RNP) antibody levels correlate with disease activity in a patient with systemic lupus erythematosus (SLE) nephritis. (8137536)	Guialis A.... Moutsopoulos H.M.	1994	RPL5, RNPC3
46	Biosynthesis of the gp330/44-kDa Heymann nephritis antigenic complex: assembly takes place in the ER. (8322889)	Biemesderfer D.... Farquhar M.G.	1993	LRP2, LRPAP1
47	Analysis of plasmin binding and urokinase activation of plasminogen bound to the Heymann nephritis autoantigen, gp330. (1280065)	Kanalas J.J.	1992	LRP2
48	Role of antibodies to tubulointerstitial nephritis antigen in human anti-tubular basement membrane nephritis associated with membranous nephropathy. (1466368)	Katz A.... Butkowski R.J.	1992	TINAG
49	Characterization of a tubular basement membrane compo nent reactive with autoantibodies associated with tubulointerstitial nephritis. (2250013)	Butkowski R.J.... Andres G.A.	1990	NID1
50	Identification of a target antigen in human anti-tubular basement membrane nephritis. (3553704)	Fliger F.D.... Butkowski R.J.	1987	TINAG

Genes related to nephritis according to GeneCards:

(show top 50)    (show all 260)

id	Symbol	Description	Score	GeneCards Section Context
1	TINAGL1	tubulointerstitial nephritis antigen-like 1	11.1	Transcripts, Orthologs, Summaries, Aliases & Descriptions
2	TINAG	tubulointerstitial nephritis antigen	11.1	UniProt Related, Orthologs, Aliases & Descriptions, Transcripts (show all 7 sections) Publications, Summaries, Proteins
3	COL4A5	collagen, type IV, alpha 5	11.0	Publications, Summaries
4	SLEN3	systemic lupus erythematosus with nephritis 3	11.0	Aliases & Descriptions
5	SLEN1	systemic lupus erythematosus with nephritis 1	11.0	Aliases & Descriptions
6	SLEN2	systemic lupus erythematosus with nephritis 2	11.0	Aliases & Descriptions
7	LRP2	low density lipoprotein receptor-related protein 2	11.0	Aliases & Descriptions, Publications
8	TRDN	triadin	11.0	Summaries
9	FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	11.0	Publications
10	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
11	RBP4	retinol binding protein 4, plasma	11.0	Publications
12	FCGR3A	Fc fragment of IgG, low affinity IIIa, receptor (CD16a)	11.0	Publications
13	GATA3	GATA binding protein 3	11.0	Publications
14	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
15	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
16	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
17	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
18	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
19	FN1	fibronectin 1	11.0	Publications
20	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
21	CD40LG	CD40 ligand	11.0	Publications
22	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
23	ALB	albumin	11.0	Publications
24	CR1	complement component (3b/4b) receptor 1 (Knops blood group)	11.0	Publications
25	C3AR1	complement component 3a receptor 1	11.0	Publications
26	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	11.0	Publications
27	NPHS2	nephrosis 2, idiopathic, steroid-resistant (podocin)	11.0	Publications
28	C4A	complement component 4A (Rodgers blood group)	11.0	Publications
29	CCR4	chemokine (C-C motif) receptor 4	11.0	Publications
30	LCN2	lipocalin 2	11.0	Publications
31	CFB	complement factor B	11.0	Publications
32	SULT1A3	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3	11.0	Publications
33	RNPC3	RNA-binding region (RNP1, RRM) containing 3	11.0	Publications
34	DNASE1	deoxyribonuclease I	11.0	Publications
35	NPHS1	nephrosis 1, congenital, Finnish type (nephrin)	11.0	Publications
36	PDCD1	programmed cell death 1	11.0	Publications
37	UMOD	uromodulin	11.0	Publications
38	C5AR1	complement component 5a receptor 1	11.0	Publications
39	CTSG	cathepsin G	11.0	Publications
40	CD274	CD274 molecule	11.0	Publications
41	DNTT	deoxynucleotidyltransferase, terminal	11.0	Publications
42	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
43	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif, 13	11.0	Publications
44	IL17A	interleukin 17A	11.0	Publications
45	TLR9	toll-like receptor 9	11.0	Publications
46	CIITA	class II, major histocompatibility complex, transactivator	11.0	Publications
47	IL18R1	interleukin 18 receptor 1	11.0	Publications
48	MYH9	myosin, heavy chain 9, non-muscle	11.0	Publications
49	CSF1	colony stimulating factor 1 (macrophage)	11.0	Publications
50	B2M	beta-2-microglobulin	11.0	Publications

Pathways related to nephritis according to GeneDecks:

(show top 50)    (show all 134)

id	Pathway	Score	Top Affiliating Genes
1	Systemic lupus erythematosus20	11.6	CD86, CD40LG, CD80, CD40, FCGR1A, FCGR2A
2	Staphylococcus aureus infection20	11.4	SELP, CFB, ITGAM, ITGB2, FCGR1A, FCGR2A
3	Tuberculosis20	11.4	CIITA, CD209, ITGAM, ITGB2, FCGR1A, FCGR2A
4	Immune System38	11.3	PDCD1, VCAM1, LGALS3, CIITA, MX1, MT2A
5	Intestinal immune network for IgA production20	11.2	CD86, CD40LG, CD80, CD40, ITGA4, IL10
6	TNF Superfamily Pathway36	11.1	FADD, CASP3, TRAF1, TRAF2, TRADD, TNF
7	RAR-Gamma-RXR-Alpha Degradation36	11.1	CD80, IL11, IL12A, IL2, IL20, CCL3
8	Akt Signaling36	11.1	CD4, CD80, ITGAM, ITGB2, MET, IL10
9	Rheumatoid arthritis20	11.1	VEGFA, CD86, CD80, ITGB2, MMP3, IL11
10	Th1 Differentiation37	11.0	CD86, CD4, CD80, IL10, IL12A, IL18
11	Endothelin-1 Signaling Pathway36	10.9	BMP6, CD80, IL10, IL11, IL12A, IL13
12	Leishmaniasis20	10.8	ITGA4, ITGAM, ITGB2, FCGR1A, FCGR2A, FCGR3A
13	Influenza A20	10.8	CIITA, MX1, IL12A, IL18, IL6, IL8
14	STAT3 Pathway36	10.8	BMP6, CDKN1A, CD4, CD80, MET, IL10
15	Measles20	10.8	MX1, CD209, FCGR2B, IL12A, IL13, IL2
16	Complement and coagulation cascades20	10.7	VWF, SERPINA1, SERPINE1, CFB, CD59, FGB
17	African trypanosomiasis20	10.7	SELE, VCAM1, IL10, IL12A, IL18, IL6
18	Allograft rejection20	10.6	CD86, CD40LG, CD80, CD40, IL10, IL12A
19	PEDF Induced Signaling36	10.6	BMP6, CD80, IL10, IL11, IL12A, IL13
20	MIF Mediated Glucocorticoid Regulation36	10.6	BMP6, CD80, IL10, IL11, IL12A, IL13
21	MIF Regulation of Innate Immune Cells36	10.6	BMP6, CD80, IL10, IL11, IL12A, IL13
22	all-trans-Retinoic Acid Signaling in Brain36	10.6	BMP6, CD80, IL10, IL11, IL12A, IL13
23	Toxoplasmosis20	10.6	CIITA, LAMA1, CD40LG, CD40, IL10, IL10RA
24	THC Differentiation Pathway36	10.6	CD86, IL10, IL10RA, IL12A, IL18, IL18R1
25	Chagas disease (American trypanosomiasis)20	10.6	SERPINE1, IL10, IL12A, IL2, IL6, IL8
26	Autoimmune thyroid disease20	10.5	CD86, CD40LG, CD80, CD40, IL10, IL2
27	NFAT Signaling and Lymphocyte Interactions36	10.5	BMP6, CD4, CD80, IL11, IL12A, IL13
28	PAK Pathway36	10.4	BMP6, CD80, MET, IL10, IL11, IL12A
29	Glucocorticoid Receptor Signaling36	10.4	BMP6, CDKN1A, CD4, CD80, FKBP4, IL10
30	Molecular Mechanisms of Cancer36	10.4	BMP6, LAMA1, CDKN1A, CD4, CD80, ITGA4
31	IL-6 Pathway36	10.4	BMP6, CD80, IL10, IL11, IL12A, IL18
32	Antioxidant Action of Vitamin-C36	10.2	BMP6, CD4, CD80, MET, IL10, IL10RA
33	p38 Signaling36	10.2	BMP6, CD4, CD80, MET, IL10, IL10RA
34	Amoebiasis20	10.1	LAMA1, ITGAM, ITGB2, FN1, IL12A, IL1R1
35	Cell adhesion molecules (CAMs)20	10.1	SELP, CD86, CD4, CD80, CD40, ITGA4
36	Rho Family GTPases36	10.1	BMP6, LAMA1, CD80, ITGA3, ITGA4, ITGAM
37	JNK Pathway36	10.1	BMP6, CD4, CD80, IL18R1, IL1R1, IL2
38	PGC1Alpha Pathway36	10.0	BMP6, CD4, CD80, IL10RA, IL11, IL12A
39	Regulation of eIF4 and p70S6K36	10.0	CD4, CD80, ITGA3, ITGA4, ITGAM, ITGB2
40	ERK Signaling36	9.9	BMP6, LAMA1, CD80, ITGA3, ITGA4, ITGAM
41	Tec Kinases Signaling36	9.9	BMP6, CD4, CD80, ITGA3, ITGA4, ITGAM
42	Malaria20	9.9	SELE, SELP, VCAM1, CD36, CD40LG, CD40
43	Transendothelial Migration of Leukocytes36	9.8	VCAM1, LAMA1, ITGA3, ITGA4, ITGAM, ITGB2
44	MAPK Family Pathway36	9.6	BMP6, CD4, CD80, MET, IL10, IL10RA
45	Cytokine-cytokine receptor interaction20	9.6	VEGFA, LEP, CD40LG, CD40, MET, IL10
46	TGF-Beta Pathway36	9.5	BMP6, CD4, CD80, MET, IL10, IL10RA
47	JAK-STAT Pathway36	9.4	BMP6, CD4, CD80, MET, IL10, IL10RA
48	Hematopoietic cell lineage20	9.2	CD36, CD59, CD4, ITGA3, ITGA4, ITGAM
49	Cell adhesion ECM remodeling10	8.9	SERPINE1, LAMA1, MMP12, MMP2, MMP3, MMP9
50	Cell adhesion_ECM remodeling41	8.8	SERPINE1, LAMA1, MMP12, MMP2, MMP3, MMP9

Compounds related to nephritis according to GeneDecks:

(show top 50)    (show all 514)

id	Compound	Score	Top Affiliating Genes
1	glucose32	11.2	RARRES2, UMOD, MT2A, CFB, FST, MKI67
2	rituximab32 34 9 9	14.1	MTOR, CD79A, CD59, CD40LG, CD80, CD40
3	nadph32 18	12.0	FCGR3B, CYP2B6, CYP2C19, CYP3A5, PRTN3, OGDH
4	adalimumab32 9 9	13.0	CD79A, MMP3, FCGR1A, FCGR2A, FCGR2B, FCGR3A
5	ionomycin32	10.8	CD274, CD40, CCL3, TNFRSF1A, TNFRSF4, EGR1
6	oxygen32 18	11.6	RBP4, SERPINA1, NAGLU, PARP1, LGALS3, CIITA
7	estradiol32 9 18 9	13.6	REN, PCNA, SERPINE1, MTOR, FST, MKI67
8	endotoxin32	10.6	CIITA, S100A8, AZU1, CD86, CD40, ITGAM
9	pravastatin32 34 9 18 9	14.3	SELE, SELP, SERPINE1, LPA, IL18, IL6
10	dopamine32 9 18 9	13.3	REN, RBP4, SELE, NAGLU, BMP6, CIITA
11	latex32	10.2	VWF, RBP4, NAGLU, LGALS3, ITGAM, FN1
12	homocysteine32 18	11.2	VWF, SELE, SELP, SERPINE1, NAGLU, LPA
13	vitamin-e32	10.1	RBP4, NAGLU, LPA, VCAM1, B2M, CD40
14	candesartan32 9 9	12.1	REN, SELP, SERPINE1, VEGFA, MMP2, CCL2
15	nitric oxide32 9 18 9	13.1	REN, SELE, SELP, SERPINA1, NAGLU, LPA
16	agar32	10.0	FST, CD40LG, FN1, MET, GLA, ERVW-1
17	ns 39832 42	11.0	PCNA, PARP1, IL17A, IL8, HMOX1, TNF
18	sialic acid32	10.0	RBP4, NAGLU, LPA, CD79A, CD59, APOC3
19	p00332	10.0	SERPINA1, SERPINE1, LEP, MKI67, IL13, IL1R1
20	methacholine32 9 9	12.0	REN, MPO, CD79A, ITGA4, IL13, IL17A
21	carbohydrates32	10.0	SELE, SELP, VCAM1, LGALS3, CIITA, CD209
22	lipid32	9.8	LRP2, LRPAP1, RBP4, SELE, SERPINA1, SERPINE1
23	polyethylene glycol32	9.8	SELE, MPO, FN1, APOA1, MB, HP
24	celecoxib32 42 34 9 18 9	14.6	REN, PCNA, VEGFA, PARP1, CDKN1A, MMP2
25	acetylcholine32 9 18 9	12.6	VWF, BMP6, LEP, MPO, CD79A, CD40LG
26	polyacrylamide32	9.6	RBP4, SERPINA1, LPA, LGALS3, S100A8, AZU1
27	nifedipine32 9 9	11.5	REN, SELE, SERPINE1, NAGLU, BMP6, LEP
28	phorbol32	9.4	RBP4, CDKN1A, CD4, CD40, ITGAM, ITGB2
29	simvastatin32 34 42 9 18 9	14.3	VWF, RBP4, SELE, SELP, SERPINE1, VEGFA
30	atorvastatin32 34 9 18 9	13.2	VWF, SELE, SELP, SERPINE1, VEGFA, LPA
31	calcitriol32 42 9 18 9	13.1	LRP2, REN, BMP6, S100A8, B2M, CDKN1A
32	neopterin32	9.1	NAGLU, MX1, LCN2, B2M, CD79A, CD4
33	superoxide32 18	10.0	NAGLU, LPA, VCAM1, LGALS3, LCN2, MT2A
34	wortmannin32 42	9.9	VCAM1, LGALS3, LEP, MTOR, CDKN1A, CD86
35	pentoxifylline32 9 9	10.8	SELP, NAGLU, VCAM1, BMP6, MPO, ITGA4
36	5fluorouracil32	8.7	PCNA, SELE, VEGFA, MTOR, MPO, CDKN1A
37	butyrate32	8.7	PCNA, BMP6, LGALS3, LEP, B2M, MPO
38	troglitazone32 42 9 9	11.4	SELE, SERPINE1, VCAM1, BMP6, LEP, CDKN1A
39	norepinephrine32 9 18 9	11.1	REN, VWF, SELE, SELP, VCAM1, BMP6
40	sb 20358032 42	9.1	SELE, VEGFA, VCAM1, BMP6, PARP1, CDKN1A
41	cytochalasin d32 42	9.0	VWF, SELE, VCAM1, CD36, ITGA4, ITGB2
42	8-isoprostane32	8.0	SELE, SERPINE1, VCAM1, LEP, XDH, MPO
43	glutamine32	7.9	VWF, PCNA, BMP6, LGALS3, B2M, CD36
44	actinomycin d32	7.6	SELE, SERPINE1, VEGFA, LPA, PARP1, CIITA
45	lactate32	7.5	VWF, PCNA, RBP4, SELE, SELP, NAGLU
46	genistein32 9 18 9	10.4	PCNA, SELE, SELP, SERPINE1, VEGFA, VCAM1
47	estrogen32	6.5	VWF, PCNA, RBP4, SERPINA1, SERPINE1, LPA
48	paraffin32	INF	VWF, PCNA, SERPINA1, VEGFA, VCAM1, LGALS3
49	uric acid32 18	INF	RBP4, SERPINE1, NAGLU, LPA, UMOD, LEP
50	matrigel32	INF	VWF, SELE, SERPINE1, VEGFA, VCAM1, BMP6

Cellular components related to nephritis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	10.2	CXCR3, CD40, CD274, CD40LG, CD4, CD86
2	extracellular matrix	GO:031012	9.9	LAMA1, LGALS3, RARRES2, CFP, FN1, APOH
3	platelet alpha granule lumen	GO:031093	9.8	SERPINA1, TIMP1, HGF, TGFB2, TGFB1, EGF
4	membrane raft	GO:045121	9.7	TNF, TNFRSF1A, THY1, PODXL, NPHS1, NPHS2
5	cell surface	GO:009986	9.4	ADAMTS13, VEGFA, CCR5, APOH, IL1R1, ITGA4
6	extracellular space	GO:005615	7.1	SOD1, CXCL5, CXCL16, CXCL13, CXCL10, PRSS1
7	extracellular region	GO:005576	6.0	PRSS1, COL4A3, COL4A5, CRP, CTSG, SPP1
8	plasma membrane	GO:005886	INF	F3, MET, FGB, ITGB2, ITGAM, ITGA4
9	integral to plasma membrane	GO:005887	INF	CCR4, TNFSF12, ICAM1, CMKLR1, SELP, ICOSLG

Biological processes related to nephritis according to GeneDecks:

(show top 50)    (show all 61)

id	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:006955	11.7	IL2RA, CIITA, CMKLR1, CFP, CD86, CD4
2	cell-cell signaling	GO:007267	11.6	IL11, IL10, ISG15, ITGB2, CD80, CD86
3	innate immune response	GO:045087	11.5	TNFAIP3, CFB, LCN2, MX1, LGALS3, TRAF2
4	interferon-gamma-mediated signaling pathway	GO:060333	11.4	HLA-DQB1, HLA-DPB1, HLA-DQA1, ICAM1, OAS1, IFNG
5	induction of apoptosis	GO:006917	11.3	CASP3, C5, TGFB2, PDCD5, MX1, FASLG
6	inflammatory response	GO:006954	11.3	C3AR1, C5, CSF1, CXCL10, TGFB1, TLR9
7	cytokine-mediated signaling pathway	GO:019221	11.3	CIITA, OAS1, CCL2, CCR2, IL6, B2M
8	T cell costimulation	GO:031295	11.2	MTOR, PDCD1, CD86, HLA-DRB1, HLA-DQB1, HLA-DQA1
9	leukocyte cell-cell adhesion	GO:007159	11.1	CD40LG, VCAM1, ICAM1, CCL5, ITGB2, ITGA4
10	chemotaxis	GO:006935	11.0	IL4, S100A8, CMKLR1, CCR2, CCL2, CCR4
11	elevation of cytosolic calcium ion concentration	GO:007204	11.0	IL2, C3AR1, ADM, C5AR1, CXCR3, CXCL13
12	positive regulation of inflammatory response	GO:050729	11.0	CCL3, AGTR1, TNFSF4, TNFRSF1A, SERPINE1, IL18
13	cellular response to tumor necrosis factor	GO:071356	10.9	ICAM1, CCL5, CCL3, CCL2, ANKRD1, IL8
14	positive regulation of interferon-gamma production	GO:032729	10.9	LTA, TNFSF4, TNF, CCR2, IL2, IL18
15	cellular response to mechanical stimulus	GO:071260	10.9	IL18, FADD, FAS, ANKRD1, TNFRSF10A, CD40
16	induction of apoptosis via death domain receptors	GO:008625	10.8	FAS, TNFRSF10B, TNFRSF10A, TNF, FASLG, FADD
17	neutrophil chemotaxis	GO:030593	10.8	IL8, CCL2, CCL3, IFNG, SPP1, EDN3
18	induction of apoptosis by extracellular signals	GO:008624	10.6	FASLG, CASP3, FAS, TRAF2, TRADD, TNF
19	aging	GO:007568	10.6	F3, CCL5, CCL2, FAS, LRP2, PTGS1
20	positive regulation of MHC class II biosynthetic process	GO:045348	10.6	CIITA, IFNG, IL4, IL10, AZU1, CD40LG
21	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.4	TNFSF10, XDH, FASLG, TRAF2, TRADD, TNF
22	response to amino acid stimulus	GO:043200	10.4	ICAM1, TIMP3, EDN1, NOS3, TNFRSF1A, CCL2
23	response to wounding	GO:009611	10.4	TGFB1, TGFB2, VWF, FN1, MET, CCR2
24	positive regulation of transcription from RNA polymerase II promoter	GO:045944	10.4	IL11, CIITA, PAX2, BMP6, VEGFA, SERPINE1
25	leukocyte migration	GO:050900	10.4	SELP, MYH9, PODXL, THBD, ELANE, ITGA3
26	signal transduction	GO:007165	10.3	EPO, ADM, C5AR1, NPHP1, NR3C1, CXCL5
27	cellular response to interleukin-1	GO:071347	10.3	ANKRD1, MMP9, EDN1, IL8, CCL5, CCL3
28	response to estrogen stimulus	GO:043627	10.1	ESR1, CCL5, TIMP3, FAS, SERPINE1, TNFRSF11B
29	response to drug	GO:042493	10.1	LTC4S, EDN1, TGFB1, TGFB2, TGIF1, SOD1
30	cell surface receptor signaling pathway	GO:007166	10.1	IL1R1, C5, LAMA1, MET, CD59, EDN1
31	negative regulation of growth of symbiont in host	GO:044130	10.0	CD36, IL10, ELANE, MBL2, CTSG, LTA
32	cellular response to lipopolysaccharide	GO:071222	10.0	SERPINE1, CD36, IL10, IL8, ANKRD1, CCL2
33	positive regulation of angiogenesis	GO:045766	9.8	F3, VEGFA, ADM, C3AR1, C5, NOS3
34	response to hypoxia	GO:001666	9.8	CCL2, TNF, MB, TNFRSF1A, CRP, NOS1
35	positive regulation of MAP kinase activity	GO:043406	9.8	TGFB1, ELANE, EGF, EDN3, TNF, CD40
36	positive regulation of isotype switching to IgG isotypes	GO:048304	9.8	TBX21, IL4, IL2, CD40, IFNG
37	anti-apoptosis	GO:006916	9.8	TNF, HGF, CCL2, SOD1, RPS27A, NOS3
38	response to organic cyclic compound	GO:014070	9.8	TIMP3, SERPINA1, NOS3, CTSB, ICAM1, IL4
39	positive regulation of tumor necrosis factor production	GO:032760	9.7	FADD, IL18, TLR9, PF4, CD36, IFNG
40	angiogenesis	GO:001525	9.7	ANXA2, IL18, IL8, MMP2, CCL2, HMOX1
41	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.6	CD36, FADD, CD40, FASLG, HMOX1, TRAF1
42	positive regulation of cell proliferation	GO:008284	9.6	TNFSF13, TNFSF13B, EPO, LEP, EDN1, CD86
43	response to ethanol	GO:045471	9.3	GATA3, SOD1, S100A8, MMP9, IL13, IL4
44	response to lipopolysaccharide	GO:032496	9.3	ADM, CXCL10, THBD, ELANE, EPO, EDN1
45	extracellular matrix organization	GO:030198	9.2	TIMP1, AGT, ELANE, COL4A4, COL4A3, COL17A1
46	proteolysis	GO:006508	8.8	CFB, REN, ADAMTS13, PRTN3, MMP9, LPA
47	platelet activation	GO:030168	8.6	ADAMTS13, ALB, IL6, APOA1, GP6, IL11
48	platelet degranulation	GO:002576	8.3	CD36, HGF, SOD1, TF, TGFB2, TGFB1
49	blood coagulation	GO:007596	7.9	ITGAM, FN1, EGF, TIMP1, THBD, NOS1
50	apoptotic process	GO:006915	INF	DNASE1, TRAF2, TRADD, TNF, TNFRSF10B, TNFRSF11B

Molecular functions related to nephritis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	receptor binding	GO:005102	11.4	ICOSLG, C5, CXCL16, CXCL10, TGFB2, TRDN
2	tumor necrosis factor receptor binding	GO:005164	11.0	TNFSF12, LTA, TNFSF4, TNFSF13B, TNFSF13, TNFSF10
3	cytokine activity	GO:005125	10.9	TNFSF10, IL20, IL4, IL6, FASLG, IFNG
4	receptor activity	GO:004872	10.7	THBD, TNFRSF11B, TNFRSF10B, TNFRSF10A, ICAM1, GP6
5	IgG binding	GO:019864	10.6	FCGR1A, FCGR2A, FCGR2B, FCGR3A, FCGR3B, FCGRT
6	heme binding	GO:020037	10.3	NOS2, NOS1, CYP2C9, CYP3A5, CYP2C19, CYP2B6
7	chemokine activity	GO:008009	10.3	CCL2, CCL3, CCL5, PF4, CXCL10, CXCL13
8	heparin binding	GO:008201	9.9	FN1, MPO, AZU1, LPA, VEGFA, SELP
9	protease binding	GO:002020	9.6	SERPINA1, SERPINE1, CST3, ELANE, TNFRSF1A, TNFAIP3
10	growth factor activity	GO:008083	9.1	EGF, AGT, TGFB1, TGFB2, CSF1, HGF
11	protein binding	GO:005515	INF	TNFRSF12A, PARP1, PAX2, LGALS3, CIITA, MX1