MCID: NPH051
MIFTS: 55

Nephritis malady

Summaries for Nephritis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Nephritis is inflammation of the kidneys and may involve the glomeruli, tubules, or interstitial tissue... more...

MalaCards: Nephritis is related to lupus nephritis and uveitis. An important gene associated with Nephritis is TINAG (tubulointerstitial nephritis antigen), and among its related pathways are Leishmaniasis and Classical antibody-mediated complement activation. The drug magnesium sulfate and the compounds calcium and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain, and related mouse phenotypes are homeostasis/metabolism and immune system.

Aliases & Classifications for Nephritis

Sources:
10DISEASES, 45Novoseek, 61UMLS
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Aliases & Descriptions:

nephritis 10 45 61


Related Diseases for Nephritis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Nephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 379)
idRelated DiseaseScoreTop Affiliating Genes
1lupus nephritis31.9CCL2, FCGR3A, FCGR2A, APOH, GATA3, RBP4
2uveitis31.2CXCR3, LTA, CCL2
3systemic lupus erythematosus31.1FCGR2A
4alport syndrome30.6COL4A5, CD79A
5vasculitis30.6CCL2, APOH, CD40LG, CD79A
6membranous glomerulonephritis30.5TINAG, CCL2, CD79A, LRP2
7tuberculosis30.4IL18, CXCR3, CD79A
8arthritis30.4FCGR3A, FCGR2A, IL18, CXCR3, LTA, CCL2
9proliferative glomerulonephritis30.4CCL2, CD79A, CXCR3
10primary biliary cirrhosis30.2LTA, CD40LG, CD79A
11hepatitis c30.2IL18, CXCR3, CD40LG
12thrombocytopenia30.0APOH, CD40LG, CD79A, FCGR2A, FCGR3A
13antiphospholipid syndrome30.0CD79A, CD40LG, APOH
14autoimmune hemolytic anemia30.0CD40LG, CD79A
15lipoid nephrosis30.0CD79A, CCL2
16cryoglobulinemia29.9CD79A, CD40LG, APOH
17ulcerative colitis29.9LTA, CD79A, CXCR3, IL18
18focal segmental glomerulosclerosis29.9CD79A, CCL2, COL4A5
19ankylosing spondylitis29.9CD79A
20vascular disease29.9APOH
21thyroiditis29.9CD79A
22infectious mononucleosis29.9CD40LG, CD79A
23atherosclerosis29.7CCL2, APOH, RBP4, CD40LG, CXCR3, IL18
24rheumatic disease29.6APOH, CD40LG, CXCR3, IL18, FCGR2A
25behcet's disease29.6APOH, LTA, IL18, LRP2
26leptospirosis29.6CD40LG
27q fever29.6CD79A
28acute pancreatitis29.6IL18
29tonsillitis29.6CD79A, LTA
30n syndrome10.9
31henoch-schoenlein purpura10.4
32megalocytic interstitial nephritis10.4
33fanconi syndrome10.4
34karyomegalic interstitial nephritis10.4
35nephrosis10.4
36hepatitis a10.3
37deafness nephritis anorectal malformation10.3
38tubulointerstitial nephritis and uveitis10.3
39bronchitis10.2
40membranoproliferative glomerulonephritis10.2
41anuria10.2
42hepatitis e10.2
43dyschondrosteosis nephritis10.2
44adult syndrome10.2
45renal tubular acidosis10.2
46crescentic glomerulonephritis10.1
47acute diffuse nephritis10.1
48acute poststreptococcal glomerulonephritis10.1
49amyloidosis10.1
50anterior uveitis10.1

Graphical network of the top 20 diseases related to Nephritis:



Diseases related to nephritis

Clinical Features for Nephritis

Drugs & Therapeutics for Nephritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Nephritis

Drug clinical trials:

Search ClinicalTrials for Nephritis

Search NIH Clinical Center for Nephritis

Search CenterWatch for Nephritis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Nephritis

Anatomical Context for Nephritis

Sources:
33MalaCards
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MalaCards organs/tissues related to Nephritis:

33
Skin, Liver, Brain, Kidney, Lung, Bone marrow, Whole blood, Heart, Smooth muscle, Pancreas, Thyroid, Prostate, Tonsil, Myeloid, Monocytes, T cells, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid

Animal Models for Nephritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Nephritis

Sources:
51PubMed
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Articles related to Nephritis:

(show top 50)    (show all 1905)
idTitleAuthorsYear
1
Urinary MCP-1/creatinine in Henoch-SchAPnlein purpura and its relationship with nephritis. (24414608)
2014
2
Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis with poor kidney function: a subgroup analysis of the Aspreva Lupus Management Study. (23375819)
2013
3
ABIN1 dysfunction as a genetic basis for lupus nephritis. (23970121)
2013
4
Mannose-binding lectin blunts macrophage polarization and ameliorates lupus nephritis. (23626823)
2013
5
Number and function of peripheral blood endothelial progenitor cells in Henoch-SchAPnlein purpura nephritis children with different degrees of renal vascular lesions. (23403796)
2013
6
Association study of ACE and eNOS single nucleotide polymorphisms with Henoch-SchAPnlein purpura nephritis. (22895845)
2012
7
Soluble VEGF receptor 1 promotes endothelial injury in children and adolescents with lupus nephritis. (22147121)
2012
8
Rituximab versus oral cyclophosphamide for treatment of relapses of proliferative lupus nephritis: a clinical observational study. (22586177)
2012
9
European genetic ancestry is associated with a decreased risk of lupus nephritis. (23023776)
2012
10
Unexpected recovery from longterm renal failure in severe diffuse proliferative lupus nephritis. (22867270)
2012
11
The role of nephritis-associated plasmin receptor (NAPlr) in glomerulonephritis associated with streptococcal infection. (23118507)
2012
12
Outcome of patients with membranous lupus nephritis in Cape Town South Africa. (22610989)
2012
13
Renal vein thrombosis with pulmonary embolism: first manifestation of lupus nephritis. (21599786)
2011
14
Use of rituximab in combination with high-dose methotrexate in the treatment of primary central nervous system lymphoma in a mycophenolate mofetil treated patient with lupus nephritis. (20670084)
2011
15
Nephritis associated with infectious bronchitis virus Cal99 variant in game chickens. (22017040)
2011
16
Significance of glomerular activation of the alternative pathway and lectin pathway in lupus nephritis. (21893562)
2011
17
Retinoic acid-inducible gene-I (RIG-I) is induced by IFN-{gamma} in human mesangial cells in culture: possible involvement of RIG-I in the inflammation in lupus nephritis. (20167631)
2010
18
C/EBP-beta modulates transcription of tubulointerstitial nephritis antigen in obstructive uropathy. (19297554)
2009
19
Myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis with diffuse tubulointerstitial nephritis. (19557721)
2009
20
Mesalazine-induced interstitial nephritis. (19212915)
2009
21
Acute allergic interstitial nephritis and eosinophiluria. (18379530)
2008
22
Relationship between cryoglobulinemia-associated nephritis and HCV infection. (20477577)
2008
23
Lupus nephritis complicated with malignant hypertension: from renal vascular pathology to clinical relevance. (18686626)
2008
24
Drug-induced granulomatous interstitial nephritis in a pediatric patient. (17039330)
2007
25
Histological investigation of renal pathological changes in MPO-ANCA-related nephritis using repeat renal biopsies]. (17578190)
2007
26
Recurrence of Henoch-Schoenlein purpura nephritis after long-term remission in a 15-year-old girl. (16721585)
2006
27
Fluoroquinolone-induced acute interstitial nephritis in immunocompromised patients: two case reports. (16204275)
2006
28
Cockayne syndrome with recurrent acute tubulointerstitial nephritis. (17040291)
2006
29
Activation of the lectin complement pathway in Henoch-SchAPnlein purpura nephritis. (15685507)
2005
30
Polymorphoneutrophilic infiltration in acute interstitial nephritis of SjAPgren syndrome. (15166751)
2004
31
Seven cases of granulomatous interstitial nephritis in the absence of extrarenal sarcoid. (12543881)
2003
32
Partial lipodystrophy and rapidly progressive nephritis. (18209372)
2001
33
Ranitidine-induced acute interstitial nephritis in a cadaveric renal allograft. (11431197)
2001
34
Cephotaxime-associated allergic interstitial nephritis and MPO-ANCA positive vasculitis. (10803769)
2000
35
Acute tubulo-interstitial nephritis and renal infarction secondary to ergotamine therapy. (11071983)
2000
36
Levofloxacin-induced allergic interstitial nephritis. (11076114)
2000
37
Massive Exfoliation of Markedly Atypical Cells in Urine Resulting from Polyoma Virus Interstitial Nephritis. (11494010)
2000
38
New insights into the pathogenesis of interstitial nephritis. (10456258)
1999
39
Association of an insertion polymorphism of angiotensin-converting enzyme gene with the activity of lupus nephritis. (10099886)
1999
40
Acute tubulointerstitial nephritis and uveitis with angiotensin-converting enzyme increase. (10529642)
1999
41
Mesalazine-associated tubulo-interstitial nephritis in inflammatory bowel disease. (9582560)
1998
42
Idiopathic acute granulomatous interstitial nephritis leading to renal papillary necrosis. (9175068)
1997
43
Treatment of X-linked hereditary nephritis in Samoyed dogs with angiotensin converting enzyme (ACE) inhibitor. (9447482)
1997
44
Angiotensin-converting enzyme gene polymorphism and the clinical pathological features and progression in lupus nephritis]. (10436947)
1997
45
Tubulo-interstitial nephritis-uveitis (TINU)-syndrome with posterior uveitis. (9009365)
1996
46
Acute interstitial nephritis complicating IgA nephropathy. (8605720)
1995
47
Urine levels of soluble interleukin 2 receptor and free light chain immunoglobulins in lupus nephritis]. (8143195)
1993
48
Significance of anticardiolipin and antiendothelial cell antibodies in the nephritis of lupus. (1458929)
1992
49
Concomitant progressive deafness, chronic nephritis, and ocular lens disease. (13950238)
1963
50
Relapsing fever with nephritis and subarachnoid haemorrhage. (21003842)
1945

Genetic Variations for Nephritis

Expression for genes affiliated with Nephritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephritis

Search GEO for disease gene expression data for Nephritis.

Pathways for genes affiliated with Nephritis

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 53R&D Systems
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Compounds for genes affiliated with Nephritis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
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Compounds related to Nephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2414.9CCL2, APOH, GATA3, RBP4, TRDN, LTA
2cholesterol45 29 11 2414.8CCL2, APOH, RBP4, LTA, CXCR3, IL18
3arginine4511.8COL4A5, CCL2, APOH, CD40LG, CD79A, CXCR3
4steroid4511.7APOH, GATA3, RBP4, LTA, CD79A, CXCR3
5dexamethasone45 50 29 1114.7CCL2, GATA3, RBP4, LTA, CD40LG, CD79A
6creatinine4511.6CCL2, APOH, RBP4, CD40LG, CD79A, CXCR3
7serine4511.6COL4A5, CCL2, RBP4, LTA, CXCR3, IL18
8lipid4511.5CCL2, APOH, GATA3, RBP4, LTA, IL18
9etanercept45 50 1113.5FCGR3A, FCGR2A, IL18, CXCR3, LTA, APOH
10ivig4511.5APOH, LTA, CD40LG, CD79A, FCGR2A, FCGR3A
11allergens4511.5GATA3, CD40LG, CD79A, CXCR3, IL18, LRP2
12folate4511.5APOH, RBP4, CD40LG, CD79A, IL18, LRP2
13vegf4511.5CCL2, APOH, LTA, CD40LG, CD79A, CXCR3
14histamine45 29 2413.5CCL2, CD40LG, CD79A, CXCR3, IL18, FCGR2A
15lactate4511.4APOH, RBP4, LTA, CD40LG, CD79A, IL18
16vitamin b124511.4CCL2, APOH, CD40LG, CD79A, LRP2
17rituximab45 50 1113.4APOH, CD40LG, CD79A, FCGR2A, FCGR3A
18prednisolone45 29 1113.4APOH, LTA, CD79A, IL18, FCGR2A
19thyroxine45 2412.4RBP4, LTA, CD40LG, CD79A, LRP2
20mannose4511.3APOH, LTA, CD79A, FCGR2A, FCGR3A
21heparin45 29 11 2414.3APOH, CD40LG, CD79A, CXCR3, LRP2, FCGR2A
22fmlp4511.3CCL2, LTA, CXCR3, FCGR2A, FCGR3A
23lipoteichoic acid4511.3CCL2, APOH, LTA, IL18
24il 104511.3CCL2, LTA, CXCR3, IL18
25infliximab45 50 1113.3APOH, LTA, CXCR3, IL18
26progesterone45 60 29 11 2415.2APOH, GATA3, RBP4, LTA, CXCR3, IL18
27neopterin4511.2LTA, CD40LG, CD79A, IL18
28retinoic acid45 2412.2GATA3, RBP4, LTA, CD40LG, CD79A, IL18
29polysaccharide4511.2CCL2, CD40LG, CD79A, IL18, FCGR2A
30fibrinogen4511.2CCL2, APOH, CD40LG, CD79A, IL18
31oxygen45 2412.2FCGR3A, RBP4, CCL2
32daclizumab45 1112.1FCGR3A, FCGR2A, CD40LG
33tuberculin4511.1CD40LG, CD79A, IL18
34endotoxin4511.1CXCR3, APOH
35natalizumab45 1112.1IL18, FCGR2A, FCGR3A
36alemtuzumab45 1112.1CD40LG, FCGR2A, FCGR3A
37rantes4511.1LTA, CD40LG, CXCR3
38gluten4511.1IL18, CD79A
39adalimumab45 50 1113.1CD79A, FCGR2A, FCGR3A
40estrogen4511.1CD79A, APOH
41cysteine4511.0COL4A5, TINAG, TINAGL1, RBP4, CD40LG, CD79A
42valine4511.0RBP4, COL4A5
43il-124511.0CCL2, CD40LG, IL18
44abciximab45 1112.0FCGR3A, FCGR2A, CD40LG
45sulfolipid i4510.9CD79A, CD40LG
46groalpha4510.9CCL2, CXCR3, IL18
47okt34510.9LTA, CD40LG, CD79A
48sulfasalazine45 29 50 1113.8CD79A, CD40LG, CCL2
49sandoglobulin4510.7CD40LG, CD79A
50tgf beta14510.6CCL2, GATA3, LTA, IL18

GO Terms for genes affiliated with Nephritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.9FCGR3A, CXCR3, CD79A, CD40LG
2extracellular spaceGO:00561510.8IL18, TINAGL1, CCL2, APOH, RBP4, LTA

Biological processes related to Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1humoral immune responseGO:00695910.9LTA, GATA3, CCL2
2inflammatory responseGO:00695410.9IL18, CXCR3, CD40LG, CCL2
3cellular response to tumor necrosis factorGO:07135610.8IL18, GATA3, CCL2
4uterus developmentGO:06006510.7RBP4, GATA3
5response to ethanolGO:04547110.7CCL2, GATA3, RBP4
6B cell proliferationGO:04210010.4CD79A, CD40LG

Molecular functions related to Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1polysaccharide bindingGO:03024710.7TINAGL1, TINAG
2IgG bindingGO:01986410.4FCGR3A, FCGR2A

Products for genes affiliated with Nephritis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nephritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet