MCID: NPH051
MIFTS: 54

Nephritis malady

Summaries for Nephritis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Nephritis is inflammation of the kidneys and may involve the glomeruli, tubules, or interstitial tissue... more...

MalaCards: Nephritis is related to lupus nephritis and systemic lupus erythematosus. An important gene associated with Nephritis is TINAG (tubulointerstitial nephritis antigen), and among its related pathways are Tuberculosis and B Cell Receptor Signaling Pathway. The drug magnesium sulfate and the compounds gluten and natalizumab have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and monocytes, and related mouse phenotypes are renal/urinary system and vision/eye.

Aliases & Classifications for Nephritis

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11DISEASES, 46Novoseek, 63UMLS
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Aliases & Descriptions:

nephritis 11 46 63


Related Diseases for Nephritis

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18GeneCards, 19GeneDecks
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Diseases related to Nephritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 394)
idRelated DiseaseScoreTop Affiliating Genes
1lupus nephritis31.3CXCR3, CCL2, IL18, GATA3, RBP4, CD79A
2systemic lupus erythematosus31.3FCGR2A
3purpura31.3CD79A
4uveitis31.2CXCR3, CCL2, LTA
5lupus erythematosus31.1APOH, IL18, CD79A, CD40LG
6glomerulonephritis30.9LRP2, FCGR2A, CCL2, COL4A5, RBP4, CD79A
7alport syndrome30.8COL4A5, CD79A
8proteinuria30.7LRP2, APOH, CCL2, COL4A5, RBP4, CD79A
9vasculitis30.6APOH, CCL2, CD79A, CD40LG
10hepatitis30.5LTA, CD40LG, IL18
11tuberculosis30.5CD79A, IL18, CXCR3
12sarcoidosis30.5LTA, IL18, CCL2, CXCR3
13proliferative glomerulonephritis30.5CD79A, CCL2, CXCR3
14acute poststreptococcal glomerulonephritis30.4CD79A
15membranous glomerulonephritis30.4LRP2, TINAG, CCL2, CD79A
16eosinophilia30.2CD79A, GATA3, IL18
17arthritis30.2FCGR2A, FCGR3A, CXCR3, CCL2, IL18, LTA
18dermatitis30.2CXCR3, IL18, CD79A
19primary biliary cirrhosis30.2CD79A, CD40LG, LTA
20lipoid nephrosis30.1CCL2, CD79A
21autoimmune hemolytic anemia30.1CD79A, CD40LG
22connective tissue disease30.1APOH, CCL2, CD79A, CD40LG
23hepatitis c30.1CD40LG, IL18, CXCR3
24diabetic nephropathy30.1CCL2, IL18, RBP4
25focal segmental glomerulosclerosis30.0CD79A, RBP4
26infectious mononucleosis30.0CD79A, CD40LG
27chronic lymphocytic leukemia30.0CXCR3, CD40LG, LTA
28thrombocytopenia30.0APOH, FCGR2A, FCGR3A, CD79A, CD40LG
29glomerulosclerosis30.0CD79A, COL4A5, CCL2
30pneumonia30.0CCL2, RBP4, CD79A
31cryoglobulinemia30.0CD40LG, CD79A, APOH
32antiphospholipid syndrome30.0APOH, CD79A, CD40LG
33leukemia30.0CXCR3, RBP4, CD79A, CD40LG, LTA
34iga glomerulonephritis29.9CCL2, CD79A, CD40LG
35skin disease29.9CXCR3, IL18, CD79A
36diabetes mellitus29.9CD40LG, CD79A, RBP4, CCL2
37q fever29.9CD79A
38influenza29.9LTA, CD79A, CXCR3
39ulcerative colitis29.8LTA, CD79A, IL18, CXCR3
40interstitial lung disease29.7CD79A, CCL2
41tonsillitis29.7LTA, CD79A
42behcet's disease29.6LRP2, APOH, IL18, LTA
43rheumatoid arthritis29.6LRP2, APOH, LTA, CD40LG, CD79A, GATA3
44rheumatic disease29.6APOH, FCGR2A, CXCR3, IL18, CD40LG
45atherosclerosis29.4LRP2, APOH, FCGR2A, CXCR3, CCL2, IL18
46interstitial nephritis11.2
47tubulointerstitial nephritis and uveitis10.8
48henoch-schoenlein purpura10.4
49megalocytic interstitial nephritis10.4
50nephrotic syndrome10.4

Graphical network of the top 20 diseases related to Nephritis:



Diseases related to nephritis

Symptoms for Nephritis

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Drugs & Therapeutics for Nephritis

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Nephritis

Drug clinical trials:

Search ClinicalTrials for Nephritis

Search NIH Clinical Center for Nephritis

Search CenterWatch for Nephritis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Nephritis

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Anatomical Context for Nephritis

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34MalaCards
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MalaCards organs/tissues related to Nephritis:

34
Kidney, T cells, Monocytes, B cells, Endothelial, Liver, Bone, Skin, Testes, Lung, Thyroid, Myeloid, Smooth muscle, Heart, Bone marrow, Eye, Whole blood, Brain, Pancreas, Prostate, Tonsil

Animal Models for Nephritis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Nephritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3LRP2, CXCR3, COL4A5, GATA3, CD79A, CD40LG
2MP:00053917.9LRP2, CCL2, IL18, GATA3, RBP4, LTA
3MP:00053907.6LRP2, FCGR2A, FCGR3A, CCL2, GATA3, CD40LG
4MP:00053847.6CXCR3, CCL2, IL18, GATA3, RBP4, CD79A
5MP:00053857.4CXCR3, CCL2, IL18, COL4A5, GATA3, RBP4
6MP:00053977.1FCGR2A, FCGR3A, CXCR3, CCL2, IL18, GATA3
7MP:00053876.9CCL2, CXCR3, FCGR3A, FCGR2A, IL18, COL4A5
8MP:00107686.8LRP2, APOH, FCGR2A, CXCR3, CCL2, IL18
9MP:00053766.4LTA, LRP2, APOH, FCGR3A, CXCR3, CCL2

Publications for Nephritis

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53PubMed
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Articles related to Nephritis:

(show top 50)    (show all 1890)
idTitleAuthorsYear
1
Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis with poor kidney function: a subgroup analysis of the Aspreva Lupus Management Study. (23375819)
2013
2
Varenicline induced acute interstitial nephritis in the setting of idiopathic membranous glomerulonephritis. (24215355)
2013
3
Cefpodoxime proxetil-related hemolysis and acute interstitial nephritis. (23845192)
2013
4
Long- and short-term treatment with imatinib attenuates the development of chronic kidney disease in experimental anti-glomerular basement membrane nephritis. (23045430)
2013
5
Enhanced activity of Akt in Teff cells from children with lupus nephritis is associated with reduced induction of tumor necrosis factor receptor-associated factor 6 and increased OX40 expression. (23896866)
2013
6
Serial non-invasive assessment of antibody induced nephritis in mice using positron emission tomography. (23460853)
2013
7
Survival analysis and causes of mortality in patients with lupus nephritis. (22523116)
2012
8
The Role of Hyaluronan and CD44 in the Pathogenesis of Lupus Nephritis. (22900150)
2012
9
Long-term follow-up of a randomised controlled trial of azathioprine/methylprednisolone versus cyclophosphamide in patients with proliferative lupus nephritis. (22128082)
2012
10
Long-term outcome of lupus nephritis in Asian Indians. (22232126)
2012
11
Herpes virus infection associated with interstitial nephritis in a beaked whale (Mesoplodon densirostris). (23237059)
2012
12
Elevation of human tumor necrosis factor-like weak inducer of apoptosis in peripheral blood mononuclear cells is correlated with disease activity and lupus nephritis in patients with systemic lupus erythematosus. (21163672)
2011
13
The role of cytokines as biomarkers in systemic lupus erythematosus and lupus nephritis. (21372259)
2011
14
Predictive value of remission status after 6A months induction therapy in patients with proliferative lupus nephritis: a retrospective analysis. (21594768)
2011
15
Acute interstitial nephritis. (20336051)
2010
16
The non-muscle Myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans. (20523037)
2010
17
Estimation of monocyte-chemoattractantprotein-1 (Mcp-1) level in patients with lupus nephritis. (20374368)
2009
18
C/EBP-beta modulates transcription of tubulointerstitial nephritis antigen in obstructive uropathy. (19297554)
2009
19
Relationship between integrin-linked kinase expression and renal glomerular damage in children with Henoch-Schnlein purpura nephritis]. (20113654)
2009
20
Acute Tubular Necrosis and Interstitial Nephritis during Pemetrexed Therapy. (20740145)
2009
21
Is tubulointerstitial nephritis and uveitis syndrome associated with IgG4-related systemic disease? (18199112)
2008
22
A case report of adenovirus-related acute interstitial nephritis in a patient with AIDS. (18155541)
2008
23
Urinary lipocalin-2 is associated with renal disease activity in human lupus nephritis. (17530720)
2007
24
Imbalance of Th1/Th2 transcription factors in patients with lupus nephritis. (16461436)
2006
25
Urinary neutrophil gelatinase-associated lipocalin as a biomarker of nephritis in childhood-onset systemic lupus erythematosus. (16868980)
2006
26
IgA nephritis: ACE inhibitors, steroids, both or neither? (16980324)
2006
27
End-stage renal failure as a complication of acute tubulo-interstitial nephritis. (17642799)
2005
28
C5a promotes development of experimental lupus nephritis which can be blocked with a specific receptor antagonist. (16052609)
2005
29
Mesangial cell Fas ligand: upregulation in human lupus nephritis and NF-kappaB-mediated expression in cultured human mesangial cells. (15480896)
2004
30
Absence of association between the MCP-1 gene polymorphism and histological phenotype of lupus nephritis. (15119544)
2004
31
Thrombotic thrombocytopenic purpura complicating SjAPgren's syndrome with crescentic glomerulonephritis and membranous nephritis. (17143670)
2004
32
Pathogenesis of acute viral disease induced in fish by carp interstitial nephritis and gill necrosis virus. (15308746)
2004
33
Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. (12556395)
2003
34
Antiphospholipid antibodies in patients with lupus nephritis. (14575283)
2003
35
Combining lisinopril and l-arginine slows disease progression and reduces endothelin-1 in passive Heymann nephritis. (12911535)
2003
36
Role of the Fcgamma receptor IIa polymorphism in susceptibility to systemic lupus erythematosus and lupus nephritis: a meta-analysis. (12115187)
2002
37
Isolated sarcoid granulomatous interstitial nephritis: review of five cases at one center. (11334315)
2001
38
Acute renal failure from hemoglobinuric and interstitial nephritis secondary to iodine and mefenamic acid. (11316248)
2001
39
Wegener's granulomatosis presenting as acute suppurative interstitial nephritis. (11577128)
2001
40
Anuric acute renal failure secondary to megalocytic interstitial nephritis in a patient with Behcet's disease. (11140812)
2000
41
Increased expression of cytoplasmic tail-containing form of gp600/megalin in active Heymann nephritis. (11004703)
2000
42
Association of anticardiolipin antibodies with intraglomerular thrombi and renal dysfunction in lupus nephritis. (9709458)
1998
43
Glomerular epithelial protein 1 and podocalyxin-like protein 1 in inflammatory glomerular disease (crescentic nephritis) in rabbit and man. (8600307)
1996
44
The syndrome of lung hemorrhage and nephritis is usually an ANCA-associated condition. (8607730)
1996
45
Acute hepatitis, interstitial nephritis, and eosinophilia. (7872595)
1995
46
Autosomal recessive Alport syndrome: mutation in the COL4A3 gene in a woman with Alport syndrome and posttransplant antiglomerular basement membrane nephritis. (7780062)
1995
47
Heymann nephritis revisited--new insights into the pathogenesis of experimental membranous glomerulonephritis. (8252799)
1993
48
Significance of anticardiolipin and antiendothelial cell antibodies in the nephritis of lupus. (1458929)
1992
49
Transient arthritis with positive tests for rheumatoid factor as presenting sign of shunt nephritis. (2015013)
1991
50
Anti-cardiolipin antibody and renal microthrombi in lupus nephritis]. (1767341)
1991

Variations for Nephritis

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Expression for genes affiliated with Nephritis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephritis

Search GEO for disease gene expression data for Nephritis.

Pathways for genes affiliated with Nephritis

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51PathCards, 31KEGG, 39NCBI BioSystems Database, 55R&D Systems, 54QIAGEN
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Compounds for genes affiliated with Nephritis

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46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Nephritis according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1gluten469.9CD79A, IL18, APOH
2natalizumab46 1210.7FCGR2A, FCGR3A, IL18
3adalimumab46 52 1211.7FCGR2A, FCGR3A, CD79A
4tuberculin469.5CD40LG, CD79A, IL18
5daclizumab46 1210.5FCGR2A, FCGR3A, CD40LG
6sulfolipid i469.5CD40LG, CD79A
7alemtuzumab46 1210.5FCGR2A, FCGR3A, CD40LG
8valine469.4APOH, FCGR2A, FCGR3A, COL4A5, RBP4
9lipoteichoic acid469.3APOH, CCL2, IL18, LTA
10il 10469.3CXCR3, CCL2, IL18, LTA
11abciximab46 1210.2CD40LG, FCGR3A, FCGR2A
12il-12469.2CD40LG, IL18, CCL2
13mannose469.2APOH, FCGR2A, FCGR3A, CD79A, LTA
14prednisolone46 30 1211.1APOH, FCGR2A, IL18, CD79A, LTA
15infliximab46 52 1211.1APOH, FCGR2A, CXCR3, IL18, LTA
16mycophenolate mofetil46 52 1211.1IL18, CD79A, CD40LG, LTA
17rituximab46 52 1211.1APOH, FCGR2A, FCGR3A, CD79A, CD40LG
18vitamin b12469.1LRP2, APOH, CCL2, CD79A, CD40LG
19methotrexate52 46 1211.1APOH, FCGR3A, IL18, GATA3, CD79A
20neopterin469.0IL18, CD79A, CD40LG, LTA
21fmlp469.0FCGR2A, FCGR3A, CXCR3, CCL2, LTA
22thyroxine46 2510.0LRP2, RBP4, CD79A, CD40LG, LTA
23folate468.9LRP2, APOH, IL18, RBP4, CD79A, CD40LG
24heparin46 30 25 1211.8LRP2, APOH, FCGR2A, CXCR3, CD79A, CD40LG
25etanercept46 52 1210.8LTA, IL18, CXCR3, FCGR3A, FCGR2A, APOH
26polysaccharide468.7FCGR2A, CCL2, IL18, CD79A, CD40LG
27allergens468.7LRP2, CXCR3, IL18, GATA3, CD79A, CD40LG
28fibrinogen468.7APOH, CCL2, IL18, CD79A, CD40LG
29histamine46 30 2510.6FCGR2A, CXCR3, CCL2, IL18, CD79A, CD40LG
30ivig468.6APOH, FCGR2A, FCGR3A, CD79A, CD40LG, LTA
31herbimycin a46 629.6LTA, CD40LG, CCL2, FCGR3A
32rantes468.6LTA, CD40LG, IL18, CCL2, CXCR3
33lactate468.5APOH, IL18, RBP4, CD79A, CD40LG, LTA
34progesterone46 30 62 25 1212.4APOH, CXCR3, IL18, GATA3, RBP4, LTA
35tgf beta1468.4CCL2, IL18, GATA3, LTA
36endotoxin468.4APOH, CXCR3, CCL2, IL18, CD40LG, LTA
37pge2468.4CXCR3, CCL2, IL18, CD79A, CD40LG, LTA
38creatinine468.4APOH, CXCR3, CCL2, IL18, RBP4, CD79A
39steroid468.2LRP2, APOH, CXCR3, IL18, GATA3, RBP4
40oxygen46 259.1APOH, FCGR2A, FCGR3A, CXCR3, CCL2, IL18
41vegf468.0APOH, CXCR3, CCL2, IL18, CD79A, CD40LG
42retinoic acid46 259.0LRP2, IL18, GATA3, RBP4, CD79A, CD40LG
43cysteine468.0TINAGL1, TINAG, IL18, COL4A5, RBP4, CD79A
44lipid467.9LRP2, APOH, FCGR2A, CCL2, IL18, GATA3
45cholesterol46 30 25 1210.9LRP2, APOH, FCGR2A, FCGR3A, CXCR3, CCL2
46arginine467.8APOH, FCGR2A, FCGR3A, CXCR3, CCL2, IL18
47estrogen467.8APOH, CXCR3, IL18, GATA3, RBP4, CD79A
48dexamethasone46 52 30 1210.7CXCR3, CCL2, IL18, GATA3, RBP4, CD79A
49serine467.6LRP2, FCGR2A, CXCR3, CCL2, IL18, COL4A5
50calcium46 52 25 1210.2LRP2, APOH, FCGR2A, FCGR3A, CXCR3, CCL2

GO Terms for genes affiliated with Nephritis

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17Gene Ontology
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Cellular components related to Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.7FCGR3A, CXCR3, CD79A, CD40LG
2extracellular regionGO:0055768.0RBP4, COL4A5, IL18, CCL2, TINAGL1, FCGR3A
3extracellular spaceGO:0056157.0LTA, CD40LG, RBP4, IL18, CCL2, TINAGL1

Biological processes related to Nephritis according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1uterus developmentGO:0600659.9RBP4, GATA3
2negative regulation of endothelial cell proliferationGO:0019379.9CXCR3, APOH
3lipopolysaccharide-mediated signaling pathwayGO:0316639.7IL18, CCL2
4negative regulation of angiogenesisGO:0165259.7CCL2, CXCR3, APOH
5response to gamma radiationGO:0103329.5CCL2, GATA3
6response to ethanolGO:0454719.5RBP4, GATA3, CCL2
7angiogenesisGO:0015259.4IL18, CCL2, CXCR3
8B cell proliferationGO:0421009.3CD40LG, CD79A
9humoral immune responseGO:0069599.3LTA, GATA3, CCL2
10inflammatory responseGO:0069549.0CXCR3, CCL2, IL18, CD40LG
11immune responseGO:0069558.8FCGR3A, TINAGL1, TINAG, IL18

Molecular functions related to Nephritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:0198649.8FCGR3A, FCGR2A
2polysaccharide bindingGO:0302479.4TINAG, TINAGL1
3tumor necrosis factor receptor bindingGO:0051649.3LTA, CD40LG
4cytokine activityGO:0051258.7LTA, CD40LG, IL18

Products for genes affiliated with Nephritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nephritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet