MCID: NPH011
MIFTS: 49

Nephroblastoma malady

Summaries for Nephroblastoma

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Wilms\' tumor, Wilms tumor (/vɪlmz/), or nephroblastoma is cancer of the kidneys that typically occurs... more...

MalaCards: Nephroblastoma, also known as childhood renal wilms' cancer, is related to wilms tumor and denys-drash syndrome. An important gene associated with Nephroblastoma is NOV (nephroblastoma overexpressed). The compounds dmrt and steroid have been mentioned in the context of this disorder. Affiliated tissues include children, and related mouse phenotypes are endocrine/exocrine gland and cellular.

Disease Ontology:8 A kidney cancer that affects the kidneys and typically located in children.

Description from OMIM:47 194070

Aliases & Classifications for Nephroblastoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 57SNOMED-CT, 47OMIM, 40NCIt, 35MeSH
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Aliases & Descriptions:

nephroblastoma 8 10 61
childhood renal wilms' cancer 8
adult renal wilms' tumor 8
adult renal wilms tumor 61
adult nephroblastoma 8
renal wilms tumor 8


External Ids:

Disease Ontology8 DOID:2154
OMIM47 194070
MeSH35 D009396

Related Diseases for Nephroblastoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Nephroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 80)
idRelated DiseaseScoreTop Affiliating Genes
1wilms tumor31.1NOV, REN, CYR61, WT1, WISP3, WISP2
2denys-drash syndrome30.0NR5A1, WT1, KLF10, YIPF2
3wagr syndrome29.8FSHB, WT1
4n syndrome10.4
5cystic nephroma10.2
6aniridia10.2
7stromal predominant kidney wilms' tumor10.1
8mixed cell type kidney wilms' tumor10.1
9epithelial predominant wilms' tumor10.1
10blastema predominant kidney wilms' tumor10.1
11renal wilms' tumor10.1
12hypercalcemia10.1
13testicular germ cell tumor10.1
14teratoma10.1
15hereditary wilms' tumor10.0
16fanconi's anemia10.0
17adrenal neuroblastoma10.0
18metanephric adenoma10.0
19adenoma10.0
20horseshoe kidney10.0
21wilms tumor, type 110.0
22nephritis10.0
23mesoblastic nephroma10.0
24renal dysplasia10.0
25adrenocortical carcinoma10.0NR5A1
26sertoli-leydig cell tumor10.0WT1
27leydig cell tumor10.0NR5A1
28adrenal adenoma10.0NR5A1, MLANA, REN
29frasier syndrome10.0WT1
30addison's disease10.0NR5A1, WT1, REN
31breast cancer10.0KLF10, NOV, CYR61, NR5A1, WISP3, WISP2
32hypospadias10.0NR5A1, WT1
33sex cord-gonadal stromal tumor10.0WT1, NR5A1
34abrikosov's tumor10.0NR5A1, WT1
35ovarian cancer10.0MLANA
36leiomyosarcoma10.0WT1, MLANA
37neurofibromatosis9.9
38cervical wilms' tumor9.9
39blastoma9.9
40bone carcinoma9.9
41cloacogenic carcinoma9.9
42osteonecrosis9.9
43papillary carcinoma9.9
44xanthogranulomatous pyelonephritis9.9
45osteopetrosis9.9
46papillary renal cell carcinoma9.9
47hydronephrosis9.9
48liver inflammatory pseudotumor9.9
49alveolar rhabdomyosarcoma9.9
50childhood multilocular cystic kidney neoplasm9.9

Graphical network of the top 20 diseases related to Nephroblastoma:



Diseases related to nephroblastoma

Clinical Features for Nephroblastoma

Sources:
47OMIM
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Clinical features from OMIM:

194070

Drugs & Therapeutics for Nephroblastoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Nephroblastoma

Drug clinical trials:

Search ClinicalTrials for Nephroblastoma

Search NIH Clinical Center for Nephroblastoma

Search CenterWatch for Nephroblastoma

Genetic Tests for Nephroblastoma

Anatomical Context for Nephroblastoma

Sources:
14FMA
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FMA organs/tissues related to Nephroblastoma:

14
Children

Animal Models for Nephroblastoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Nephroblastoma

Sources:
51PubMed
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Articles related to Nephroblastoma:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Involvement of germline DDX1-MYCN duplication in inherited nephroblastoma. (24161495)
2013
2
Abdominal radiotherapy: a major determinant of metabolic syndrome in nephroblastoma and neuroblastoma survivors. (23251703)
2012
3
Bilateral botryoid nephroblastoma: a rare cause of renal failure. (22962373)
2012
4
Update on relapses in unilateral nephroblastoma registered in 3 consecutive SIOP/GPOH studies - a report from the GPOH-nephroblastoma study group. (21509706)
2011
5
Cystic partially differentiated nephroblastoma with ureteric extension. (21045434)
2010
6
Hepatic veno-occlusive disease during chemotherapy for nephroblastoma: successful and safe treatment with defibrotide. Report of a clinical case. (19874245)
2009
7
Unilateral renal tumor in a child: nephroblastoma concurrent with a rare form of (translocation?) renal-cell carcinoma]. (19938705)
2009
8
Prognostic markers in nephroblastoma (Wilms' tumor). (15922430)
2005
9
Nephroblastoma overexpressed gene (NOV) expression in rat hepatic stellate cells. (15345329)
2004
10
Changes in computed tomography features following preoperative chemotherapy for nephroblastoma: relation to histopathological classification. (14872276)
2004
11
High-dose chemotherapy with autologous stem cell rescue in children with nephroblastoma. (12476282)
2002
12
Clinical impact of histologic subtypes in localized non-anaplastic nephroblastoma treated according to the trial and study SIOP-9/GPOH. (11332141)
2001
13
Prenatal diagnosis of congenital Wilms' tumor (nephroblastoma) presenting as fetal hydrops. (11084972)
2000
14
Comparative immunohistochemical analysis of developing kidneys, nephroblastomas and related tumors: considerations on their histogenesis. (10886722)
2000
15
Cystic partially differentiated nephroblastoma in an adult: an immunohistochemical, lectin histochemical and ultrastructural study. (10383716)
1999
16
The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. (10204117)
1999
17
The noncoding and surface envelope coding sequences of myeloblastosis-associated virus are respectively responsible for nephroblastoma development and renal hyperplasia. (8642688)
1996
18
High dose consolidation with autologous stem cell rescue (ASCR) for nephroblastoma initially treated according to the SIOP 9/GPOH trial and study. (8776705)
1996
19
Recombinant interferon-alpha efficacy in relapsed adult nephroblastoma: a case report. (8283539)
1994
20
Atrial natriuretic peptide suppresses isoprenaline and dibutyryl cyclic adenosine monophosphate-induced cell growth in cultured renin-secreting human nephroblastoma cells. Comparison with forskolin-induced renin secretion. (1317905)
1992
21
DNA quantitation of Wilms' tumour (nephroblastoma) using flow cytometry and image analysis. (1320635)
1992
22
The histologic, ultrastructural, and immunohistochemical features of a blastema-predominant canine nephroblastoma. (1320304)
1992
23
T-cell lymphoma and mature nephroblastoma after synchronous bilateral Wilms' tumor. (1845941)
1991
24
Image interpretation session. Nephroblastomatosis with nephroblastoma (Wilms tumor). (1847532)
1991
25
Management of nephroblastoma with intracardiac extension: three case reports and review of the literature. (1664230)
1991
26
Spontaneous hematoma of the kidney simulating a nephroblastoma. Report of two cases. (2173442)
1990
27
Nephroblastoma in an ovotestis of a true hermaphrodite: a case report. (3033335)
1987
28
Bilateral renal dysplasia with features of nephroblastomatosis. (2832837)
1987
29
Lectin histochemistry of nephroblastoma (Wilms' tumour). (2416712)
1985
30
Mesoblastic nephromas: a study of 29 tumours from the SIOP nephroblastoma file. (2995226)
1985
31
Adult nephroblastoma with glomerular intracapillary deposits of IgM in the contralateral kidney. (2991613)
1985
32
Cystic nephroblastoma of an aged dog. (2983479)
1985
33
Skeletal effects of orthovoltage and megavoltage therapy following treatment of nephroblastoma. (6291840)
1982
34
Fetal rhabdomyomatous nephroblastoma. Pathologic histology and special clinical and biologic features. (6244961)
1980
35
Growth patterns, ultrastructure, and chromosomal constitution of normal kidney and nephroblastoma cells in short-term culture. (6247475)
1980
36
Angiographic patterns in nephroblastoma and survival. (209719)
1978
37
Management of nephroblastoma in childhood. Clinical study of two forms for maintenance chemotherapy. Medical Research Council's Working Party on embryonal tumours in childhood. (206208)
1978
38
Histopathological study of the first Medical Research Council Nephroblastoma Trial. (198098)
1977
39
Polycystic nephroblastoma. (186643)
1976
40
gamm-Glutamyl transpeptidase in human nephroblastoma grown in nude mice. (3427)
1976
41
Ultrastructure of Wilms' tumor (nephroblastoma). (176061)
1976
42
Bilateral nephroblastomatosis and Klippel Trenaunay syndrome. (4362958)
1974
43
Letter: Nephritis after irradiation and chemotherapy for nephroblastoma. (4134962)
1974
44
Letter: Nephroblastoma: index cancer. (4128087)
1973
45
Differentiated nephroblastoma: solid, cystic or mixed. (4335458)
1971
46
Nephroblastoma in Ibadan. A review of thirty-five cases. (4328983)
1971
47
A case of renal dysplasia and relation to "bilateral nephroblastomatosis". (4297414)
1968
48
Bilateral nephroblastoma in two sisters. (4289491)
1967
49
UNATTACHED NEPHROBLASTOMA. (14191143)
1964
50
Developmental anomaly of metanephros and observations on congenital nephroblastoma. (13941729)
1962

Genetic Variations for Nephroblastoma

Expression for genes affiliated with Nephroblastoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephroblastoma

Search GEO for disease gene expression data for Nephroblastoma.

Pathways for genes affiliated with Nephroblastoma

Compounds for genes affiliated with Nephroblastoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Nephroblastoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dmrt4510.5NR5A1, WT1
2steroid4510.5REN, WT1, MLANA, NR5A1, CYR61, FSHB
3cysteine4510.4CYR61, WISP2, NOV, WISP3
4estrogen4510.3FSHB, CYR61, NR5A1, WT1, WISP2, KLF10
5ptx14510.3NR5A1, FSHB
6progesterone45 60 29 11 2414.1FSHB, WT1, NR5A1, WISP2, CYR61

GO Terms for genes affiliated with Nephroblastoma

Sources:
16Gene Ontology
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Biological processes related to Nephroblastoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of female gonad developmentGO:200019510.7WT1, NR5A1
2regulation of cell growthGO:00155810.6NOV, CYR61, WISP3, WISP2
3metanephric S-shaped body morphogenesisGO:07228410.6WT1, LHX1
4branching involved in ureteric bud morphogenesisGO:00165810.6CITED1, WT1, LHX1
5cell-cell signalingGO:00726710.6LHX1, KLF10, WISP2, WISP3, NR5A1, DLL1
6positive regulation of male gonad developmentGO:200002010.6NR5A1, WT1
7mesenchymal to epithelial transitionGO:06023110.5WT1, CITED1
8male gonad developmentGO:00858410.5WT1, NR5A1, REN
9tissue developmentGO:00988810.4WT1, NR5A1
10kidney developmentGO:00182210.4REN, WT1, LHX1
11transforming growth factor beta receptor signaling pathwayGO:00717910.3FSHB, CITED1, KLF10
12adrenal gland developmentGO:03032510.1WT1, NR5A1

Molecular functions related to Nephroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor bindingGO:00552010.4NOV, CYR61, WISP3, WISP2

Products for genes affiliated with Nephroblastoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nephroblastoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet