MCID: NPH011
MIFTS: 56

Nephroblastoma malady

Nephrological diseases, Cancer diseases categories

Summaries for Nephroblastoma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Wilms\' (/vɪlmz/) tumor, Wilms tumor, or nephroblastoma is cancer of the kidneys that typically occurs... more...

MalaCards: Nephroblastoma, also known as childhood renal wilms' cancer, is related to wilms tumor and denys-drash syndrome. An important gene associated with Nephroblastoma is NOV (nephroblastoma overexpressed). The compounds dmrt and steroid have been mentioned in the context of this disorder. Affiliated tissues include children, kidney and bone, and related mouse phenotypes are endocrine/exocrine gland and cellular.

Disease Ontology:8 A kidney cancer that affects the kidneys and typically located in children.

Description from OMIM:46 194070

Aliases & Classifications for Nephroblastoma

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 46OMIM, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

nephroblastoma 8 10 60
childhood renal wilms' cancer 8
adult renal wilms' tumor 8
adult renal wilms tumor 60
adult nephroblastoma 8
renal wilms tumor 8


External Ids:

Disease Ontology8 DOID:2154
OMIM46 194070
MeSH34 D009396

Related Diseases for Nephroblastoma

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17GeneCards, 18GeneDecks
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Diseases related to Nephroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1wilms tumor30.1NOV, REN, CYR61, WT1, WISP3, WISP2
2denys-drash syndrome30.0NR5A1, WT1, KLF10, YIPF2
3breast cancer29.7KLF10, NOV, CYR61, NR5A1, WISP3, WISP2
4wagr syndrome29.7FSHB, WT1
5neuroblastoma10.5
6hepatitis10.3
7hypertension10.2
8cystic kidney10.2
9renal cell carcinoma10.2
10rhabdomyosarcoma10.2
11cystic nephroma10.2
12aniridia10.2
13stromal predominant kidney wilms' tumor10.1
14mixed cell type kidney wilms' tumor10.1
15epithelial predominant wilms' tumor10.1
16blastema predominant kidney wilms' tumor10.1
17renal wilms' tumor10.1
18hypercalcemia10.1
19hepatitis a10.1
20sarcoma10.1
21hereditary wilms' tumor10.0
22fanconi's anemia10.0
23adrenal neuroblastoma10.0
24neuronitis10.0
25metanephric adenoma10.0
26glomerulonephritis10.0
27nephrotic syndrome10.0
28wilms tumor, type 110.0
29adrenocortical carcinoma10.0NR5A1
30sertoli-leydig cell tumor10.0WT1
31leydig cell tumor10.0NR5A1
32adrenal adenoma10.0NR5A1, MLANA, REN
33frasier syndrome10.0WT1
34addison's disease10.0NR5A1, WT1, REN
35hypospadias10.0NR5A1, WT1
36sex cord-gonadal stromal tumor10.0WT1, NR5A1
37abrikosov's tumor10.0NR5A1, WT1
38ovarian cancer10.0MLANA
39leiomyosarcoma10.0WT1, MLANA
40neurofibromatosis9.9
41cervical wilms' tumor9.9
42blastoma9.9
43bone carcinoma9.9
44cloacogenic carcinoma9.9
45osteonecrosis9.9
46papillary carcinoma9.9
47xanthogranulomatous pyelonephritis9.9
48osteopetrosis9.9
49papillary renal cell carcinoma9.9
50hydronephrosis9.9

Graphical network of the top 20 diseases related to Nephroblastoma:



Diseases related to nephroblastoma

Clinical Features for Nephroblastoma

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46OMIM
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Clinical features from OMIM:

194070

Drugs & Therapeutics for Nephroblastoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Nephroblastoma

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Anatomical Context for Nephroblastoma

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Nephroblastoma:

32
Kidney, Bone, Liver, Bone marrow, Spinal cord, Lymph node, Endothelial, Lung, Ovary, Skeletal muscle, Breast, T cells, Skin

FMA organs/tissues related to Nephroblastoma:

14
Children

Animal Models for Nephroblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nephroblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.5FSHB, WT1, CITED1, NRTN, LHX1, NR5A1
2MP:000538410.5EMG1, NOV, DLL1, CYR61, MAPK8IP1, NR5A1
3MP:000536710.4NOV, DLL1, LHX1, REN, CITED1, WT1
4MP:000538510.4LHX1, AMER1, CYR61, REN, DLL1, WT1
5MP:000538010.4CYR61, NR5A1, CITED1, EMG1
6MP:000538910.4NRTN, FSHB, NR5A1, REN, LHX1, MAPK8IP1
7MP:000537810.2LHX1, NOV, DLL1, REN, MAPK8IP1, NR5A1
8MP:001076810.0NOV, REN, CYR61, EMG1, MAPK8IP1, CITED1

Publications for Nephroblastoma

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50PubMed
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Articles related to Nephroblastoma:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
Nephroblastoma: does the decrease in tumor volume under preoperative chemotherapy predict the lymph nodes status at surgery? (21538820)
2011
2
Nephroblastoma overexpressed (NOV/CCN3) gene: a paired-domain-specific PAX3-FKHR transcription target that promotes survival and motility in alveolar rhabdomyosarcoma cells. (21423212)
2011
3
Expression and prognostic value of platelet-derived growth factor-AA and its receptor I+ in nephroblastoma. (20132200)
2010
4
Recombinant expression, purification, and functional characterisation of connective tissue growth factor and nephroblastoma-overexpressed protein. (21209863)
2010
5
Anaplastic nephroblastomas express transketolase-like enzyme 1. (19139037)
2009
6
TTF-1 expression in nephroblastoma. (19011567)
2009
7
Cystic nephroma, cystic partially differentiated nephroblastoma and cystic Wilms' tumor in children: a spectrum with therapeutic dilemmas. (19172100)
2009
8
Surgical implications for liver metastases in nephroblastoma--data from the SIOP/GPOH study. (17935976)
2008
9
Role of MRI in the management of patients with nephroblastoma. (18193429)
2008
10
Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. (17500060)
2007
11
Bilateral adrenal neuroblastoma and nephroblastoma occurring synchronously in a child with Fanconi's anemia and VACTERL syndrome. (16410081)
2006
12
Primary hepatic metastases in nephroblastoma--a report of the SIOP/GPOH Study. (16410128)
2006
13
The challenge of nephroblastoma in a developing country. (16873431)
2006
14
The enhancing role of vitamin A deficiency on chemically induced nephroblastoma in rats. (16338327)
2005
15
MIB-1 and p27Kip1 expression in nephroblastoma. (15570013)
2004
16
Spinal nephroblastoma in a crossbreed dog. (15163056)
2004
17
Immunohistochemical expression of Wilms' tumor 1 protein in nephroblastoma. (15648285)
2004
18
Extradural spinal, bone marrow, and renal nephroblastoma. (12549619)
2003
19
The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma. (12569359)
2003
20
Protocol for the examination of specimens from patients with Wilms tumor (nephroblastoma) or other renal tumors of childhood. (14521468)
2003
21
Radiology case of the month. Asymptomatic abdominal mass in a child. Wilms' tumor (Nephroblastoma). (11433928)
2001
22
Differential expression of the lung resistance-related protein/major vault protein in the histological compartments of nephroblastomas. (11408938)
2001
23
Maturation in the primary and metastatic lesions of fetal rhabdomyomatous nephroblastoma. (11466727)
2001
24
Intralobar nephroblastematosis: precursor lesions of nephroblastoma in the Sprague-Dawley rat. (10490205)
1999
25
Fatal hepatic veno-occlusive disease with fibrinolysis as the cause of death during preoperative chemotherapy for nephroblastoma. (9722902)
1998
26
Extensively cystic renal neoplasms: cystic nephroma, cystic partially differentiated nephroblastoma, multilocular cystic renal cell carcinoma, and cystic hamartoma of renal pelvis. (9503503)
1998
27
Experience with six children with fetal rhabdomyomatous nephroblastoma: review of the clinical, biologic, and pathologic features. (9434822)
1998
28
Abdominal irradiation in unilateral nephroblastoma and its impact on local control and survival. (9422573)
1998
29
Nephroblastoma (Wilms' tumor): a model system of aberrant renal development. (7809506)
1994
30
Unresectable stage IV nephroblastoma: a potential indication for fine-needle aspiration biopsy in children. (8390347)
1993
31
Isolation of subclones with different tumorigenicity and metastatic ability from rat nephroblastoma cell line, ENUT. (1315113)
1992
32
Recurrent adult nephroblastoma. Long-term remission after surgery plus adjuvant high-dose chemotherapy, radiation therapy, and allogeneic bone marrow transplantation. (1317250)
1992
33
Hypertension associated with increased renin concentrations in nephroblastoma. (1851610)
1991
34
Beckwith-Wiedemann syndrome: development of nephroblastoma during the surveillance period. (2170902)
1990
35
Ras p21 expression in nephroblastoma group tumors. (2833061)
1987
36
Cystic nephroblastoma of an aged dog. (2983479)
1985
37
A new precursor lesion of Wilms' tumour (nephroblastoma): intralobar multifocal nephroblastomatosis. (6323299)
1984
38
Immunocytochemical localisation of renin in nephroblastoma. (6086723)
1984
39
Blood group antigen expression in nephroblastoma. (6093917)
1984
40
Nephroblastoma in infants, 1969-75: variations in treatment and survival. (6253020)
1980
41
Nephroblastoma. Results and complications of treatment. (231376)
1979
42
Non-function in nephroblastoma (Wilms's tumour): a report on the excretory urography of nine cases. (219984)
1979
43
Identification of a tumor-specific antigen in the insoluble fraction of human nephroblastoma. (Preliminary communication). (93541)
1979
44
The changing management of nephroblastoma. (180291)
1976
45
Nephroblastoma with keratinising cysts--(a case report). (4370214)
1974
46
A nephroblastoma in a fire-bellied newt, Cynops pyrrhogaster. (4321086)
1970
47
Polycystic nephroblastoma. (4294357)
1967
48
Bilateral nephroblastoma (Wilms' tumor). (13767382)
1961
49
A case of nephroblastoma. (13009533)
1952
50
A transplantable nephroblastoma (Wilms' tumor) and other spontaneous tumors in a colony of rats. (14778128)
1950

Genetic Variations for Nephroblastoma

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Expression for genes affiliated with Nephroblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephroblastoma

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Pathways for genes affiliated with Nephroblastoma

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Compounds for genes affiliated with Nephroblastoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Nephroblastoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dmrt4410.5NR5A1, WT1
2steroid4410.5REN, WT1, MLANA, NR5A1, CYR61, FSHB
3cysteine4410.4CYR61, WISP2, NOV, WISP3
4estrogen4410.3FSHB, CYR61, NR5A1, WT1, WISP2, KLF10
5ptx14410.3NR5A1, FSHB
6progesterone44 59 28 11 2414.1FSHB, WT1, NR5A1, WISP2, CYR61

GO Terms for genes affiliated with Nephroblastoma

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16Gene Ontology
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Biological processes related to Nephroblastoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of female gonad developmentGO:200019510.7WT1, NR5A1
2regulation of cell growthGO:00155810.6NOV, CYR61, WISP3, WISP2
3metanephric S-shaped body morphogenesisGO:07228410.6WT1, LHX1
4branching involved in ureteric bud morphogenesisGO:00165810.6CITED1, WT1, LHX1
5cell-cell signalingGO:00726710.6LHX1, KLF10, WISP2, WISP3, NR5A1, DLL1
6positive regulation of male gonad developmentGO:200002010.6NR5A1, WT1
7mesenchymal to epithelial transitionGO:06023110.5WT1, CITED1
8male gonad developmentGO:00858410.5WT1, NR5A1, REN
9tissue developmentGO:00988810.4WT1, NR5A1
10kidney developmentGO:00182210.4REN, WT1, LHX1
11transforming growth factor beta receptor signaling pathwayGO:00717910.3FSHB, CITED1, KLF10
12adrenal gland developmentGO:03032510.1WT1, NR5A1

Molecular functions related to Nephroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor bindingGO:00552010.4NOV, CYR61, WISP3, WISP2

Products for genes affiliated with Nephroblastoma

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Sources for Nephroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet