MCID: NPH011
MIFTS: 56

Nephroblastoma malady

Nephrological diseases, Cancer diseases categories

Summaries for Nephroblastoma

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Wilms\' (/vɪlmz/) tumor, Wilms tumor, or nephroblastoma is cancer of the kidneys that typically occurs... more...

MalaCards: Nephroblastoma, also known as childhood renal wilms' cancer, is related to wilms tumor and denys-drash syndrome. An important gene associated with Nephroblastoma is NOV (nephroblastoma overexpressed). The compounds dmrt and steroid have been mentioned in the context of this disorder. Affiliated tissues include children, kidney and bone, and related mouse phenotypes are endocrine/exocrine gland and cellular.

Disease Ontology:8 A kidney cancer that affects the kidneys and typically located in children.

Description from OMIM:46 194070

Aliases & Classifications for Nephroblastoma

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 46OMIM, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

nephroblastoma 8 10 60
childhood renal wilms' cancer 8
adult renal wilms' tumor 8
adult renal wilms tumor 60
adult nephroblastoma 8
renal wilms tumor 8


External Ids:

Disease Ontology8 DOID:2154
OMIM46 194070
MeSH34 D009396

Related Diseases for Nephroblastoma

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17GeneCards, 18GeneDecks
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Diseases related to Nephroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1wilms tumor30.1NOV, REN, CYR61, WT1, WISP3, WISP2
2denys-drash syndrome30.0NR5A1, WT1, KLF10, YIPF2
3breast cancer29.7KLF10, NOV, CYR61, NR5A1, WISP3, WISP2
4wagr syndrome29.7FSHB, WT1
5neuroblastoma10.5
6hepatitis10.3
7hypertension10.2
8cystic kidney10.2
9renal cell carcinoma10.2
10rhabdomyosarcoma10.2
11cystic nephroma10.2
12aniridia10.2
13stromal predominant kidney wilms' tumor10.1
14mixed cell type kidney wilms' tumor10.1
15epithelial predominant wilms' tumor10.1
16blastema predominant kidney wilms' tumor10.1
17renal wilms' tumor10.1
18hypercalcemia10.1
19hepatitis a10.1
20sarcoma10.1
21hereditary wilms' tumor10.0
22fanconi's anemia10.0
23adrenal neuroblastoma10.0
24neuronitis10.0
25metanephric adenoma10.0
26glomerulonephritis10.0
27nephrotic syndrome10.0
28wilms tumor, type 110.0
29adrenocortical carcinoma10.0NR5A1
30sertoli-leydig cell tumor10.0WT1
31leydig cell tumor10.0NR5A1
32adrenal adenoma10.0NR5A1, MLANA, REN
33frasier syndrome10.0WT1
34addison's disease10.0NR5A1, WT1, REN
35hypospadias10.0NR5A1, WT1
36sex cord-gonadal stromal tumor10.0WT1, NR5A1
37abrikosov's tumor10.0NR5A1, WT1
38ovarian cancer10.0MLANA
39leiomyosarcoma10.0WT1, MLANA
40neurofibromatosis9.9
41cervical wilms' tumor9.9
42blastoma9.9
43bone carcinoma9.9
44cloacogenic carcinoma9.9
45osteonecrosis9.9
46papillary carcinoma9.9
47xanthogranulomatous pyelonephritis9.9
48osteopetrosis9.9
49papillary renal cell carcinoma9.9
50hydronephrosis9.9

Graphical network of the top 20 diseases related to Nephroblastoma:



Diseases related to nephroblastoma

Clinical Features for Nephroblastoma

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46OMIM
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Clinical features from OMIM:

194070

Drugs & Therapeutics for Nephroblastoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Nephroblastoma

Drug clinical trials:

Search ClinicalTrials for Nephroblastoma

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Genetic Tests for Nephroblastoma

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Anatomical Context for Nephroblastoma

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Nephroblastoma:

32
Kidney, Bone, Liver, Bone marrow, Spinal cord, Lymph node, Lung, Endothelial, Skeletal muscle, Breast, Skin, Ovary, T cells

FMA organs/tissues related to Nephroblastoma:

14
Children

Animal Models for Nephroblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nephroblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.5LHX1, WT1, CITED1, NRTN, NR5A1, MAPK8IP1
2MP:000538410.5NOV, KLF10, LHX1, AMER1, WT1, CITED1
3MP:000536710.4LHX1, AMER1, WT1, CITED1, REN, DLL1
4MP:000538510.4LHX1, AMER1, WT1, CITED1, NR5A1, CYR61
5MP:000538010.4CITED1, NR5A1, EMG1, CYR61
6MP:000538910.4WT1, NRTN, NR5A1, MAPK8IP1, REN, FSHB
7MP:000537810.2LHX1, AMER1, WT1, CITED1, NR5A1, MAPK8IP1
8MP:001076810.0CITED1, WT1, AMER1, LHX1, NR5A1, MAPK8IP1

Publications for Nephroblastoma

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50PubMed
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Articles related to Nephroblastoma:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
Cystic partially differentiated nephroblastoma: A rare renal tumor. (24339528)
2013
2
Tumor biology influences the prognosis of nephroblastoma patients with primary pulmonary metastases: results from SIOP 93-01/GPOH and SIOP 2001/GPOH. (21670612)
2011
3
Nephron sparing surgery for synchronous bilateral nephroblastoma involving the renal hilus. (21855944)
2011
4
The first case of primary testicular germ cell tumor containing nephroblastoma as the only one non-germ cell component. (21715360)
2011
5
Loss of PTEN/MMAC1 activity is a rare and late event in the pathogenesis of nephroblastomas. (20381115)
2010
6
Cystic partially differentiated nephroblastoma. (20176385)
2010
7
Number of mitotic figures in microscopic picture of nephroblastoma histologic types--estimation of the value of the oldest known prognostic factor. (18655370)
2008
8
Teratoid Wilms' tumor, an important variant of nephroblastoma. (18947756)
2007
9
Repeated surgical excision for an unusual variant of nephroblastoma: case report and review of the literature. (12677600)
2003
10
Imaging of a spinal nephroblastoma in a dog. (14599165)
2003
11
Cystic partially differentiated nephroblastoma, embryonal rhabdomyosarcoma, and multiple congenital anomalies associated with variegated mosaic aneuploidy and premature centromere division: a case report. (14608201)
2003
12
Nephroblastoma in horseshoe kidney. (14562527)
2002
13
Expression and prognostic value of epidermal growth factor receptor, transforming growth factor-alpha, and c-erb B-2 in nephroblastoma. (11753991)
2001
14
The prognostic significance of apoptosis-associated proteins BCL-2, BAX and BCL-X in clinical nephroblastoma. (11720445)
2001
15
Clinical presentation and treatment outcome in children with nephroblastoma in Kenya. (11957249)
2001
16
Atypical variant of acquired von Willebrand syndrome in Wilms tumor: is hyaluronic acid secreted by nephroblastoma cells the cause? (11292185)
2001
17
Fetal rhabdomyomatous nephroblastoma: diagnosis by fine-needle aspiration cytology--a case report. (10787144)
2000
18
Possible intraspinal metastasis of a canine spinal cord nephroblastoma. (10643988)
2000
19
Heritable nephroblastoma (Wilms' tumor) in the Upjohn Sprague Dawley rat. (8799940)
1996
20
Hyperdiploidy and trisomy 12 in the cystic partially differentiated nephroblastoma. (8816896)
1996
21
Enucleative surgery for stage I nephroblastoma with a normal contralateral kidney. (8863617)
1996
22
Establishment and characterization of a cell line (NB-YK) derived from a transplantable rat nephroblastoma. (8720061)
1995
23
Hepatotoxicity in irradiated nephroblastoma patients. (7520593)
1994
24
The detection of CR1 mRNA and CR1 antigen identifies the presence of immature podocytes in a case of Wilms' tumor (nephroblastoma). (8383421)
1993
25
Excess of multifocal tumors in nephroblastoma: implications for mechanisms of tumor development and genetic counseling. (8388850)
1993
26
A cystic partially differentiated nephroblastoma producing alpha-fetoprotein. (1280914)
1992
27
Morphological characteristics of a transplantable nephroblastoma (NB-Y) in F344 rats and the relation of tumour growth to hyper-reninaemia in NB-Y-bearing rats. (1331209)
1992
28
Inactive renin levels in recurrent nephroblastoma. (1648129)
1991
29
Immunocytochemistry in fine needle aspirates of small cell-, round-, blue-cell malignant tumors of childhood (neuroblastoma, nephroblastoma, lymphoma, Ewing's sarcoma, rhabdomyosarcoma). (1669003)
1991
30
Renal vein involvement with nephroblastoma: a report of the National Wilms' Tumor Study-3. (2155790)
1990
31
Determination of plasma total renin level by RIA with a monoclonal antibody: value as a marker for nephroblastoma. (2175785)
1990
32
Wilms' tumour (nephroblastoma) in Zimbabwe. (2473707)
1989
33
Nephroblastoma with pulmonary metastases in a guanaco. (2841786)
1988
34
Neuron-specific enolase-positive rosettes in nephroblastoma: a possible diagnostic pitfall in aspiration cytology. (3032539)
1987
35
Bilateral nephroblastoma associated with a 3;17 translocation. (2983951)
1985
36
Nephroblastoma with liver and lung metastases in an adult dog. (6097732)
1984
37
Nephroblastoma associated with mesangioproliferative glomerulonephritis. (6277640)
1982
38
Malignancies associated with renal transplant: first case report of a nephroblastoma occurring in an adult host kidney. (6267326)
1981
39
Benign cystic nephroblastoma. (222590)
1979
40
Occult nephroblastoma (Wilms' tumor) presenting with symptoms of central nervous system involvement. (229703)
1979
41
Cystic nephroblastoma--a benign variant of Wilms' tumor. (214770)
1978
42
Glomerulosclerosis following irradiation and cytotoxic therapy for nephroblastoma. (199313)
1977
43
Limitation of the potentialities of nephroblastoma differentiation in vitro. (192559)
1977
44
Nephroblastoma in the rat: histology of a spontaneous tumor, identity with respect to renal mesenchymal neoplasms, and a review of previously recorded cases. (187769)
1976
45
A fetuin-like antigen from human nephroblastoma. (50293)
1975
46
The management of nephroblastoma in Kenya. (166816)
1975
47
Structure and size prognosis in nephroblastoma. (4350959)
1973
48
Cellular immunity to nephroblastoma. (4325850)
1971
49
Nervous elements in nephroblastoma. (4290816)
1966
50
Multiplicity of cell response to the BAI strain A (myeloblastosis) avian tumor virus. II. Nephroblastoma (Wilms' tumor): ultrastructure. (13906058)
1962

Genetic Variations for Nephroblastoma

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Expression for genes affiliated with Nephroblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephroblastoma

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Pathways for genes affiliated with Nephroblastoma

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Compounds for genes affiliated with Nephroblastoma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Nephroblastoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1dmrt4410.5NR5A1, WT1
2steroid4410.5FSHB, WT1, MLANA, NR5A1, CYR61, REN
3cysteine4410.4NOV, CYR61, WISP3, WISP2
4estrogen4410.3KLF10, WISP2, WT1, NR5A1, CYR61, FSHB
5ptx14410.3FSHB, NR5A1
6progesterone44 59 28 11 2414.1WISP2, WT1, NR5A1, CYR61, FSHB

GO Terms for genes affiliated with Nephroblastoma

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16Gene Ontology
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Biological processes related to Nephroblastoma according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of female gonad developmentGO:200019510.7NR5A1, WT1
2regulation of cell growthGO:00155810.6WISP2, WISP3, CYR61, NOV
3metanephric S-shaped body morphogenesisGO:07228410.6WT1, LHX1
4branching involved in ureteric bud morphogenesisGO:00165810.6LHX1, WT1, CITED1
5cell-cell signalingGO:00726710.6DLL1, NR5A1, WISP3, WISP2, LHX1, KLF10
6positive regulation of male gonad developmentGO:200002010.6WT1, NR5A1
7mesenchymal to epithelial transitionGO:06023110.5CITED1, WT1
8male gonad developmentGO:00858410.5REN, NR5A1, WT1
9tissue developmentGO:00988810.4NR5A1, WT1
10kidney developmentGO:00182210.4LHX1, WT1, REN
11transforming growth factor beta receptor signaling pathwayGO:00717910.3FSHB, CITED1, KLF10
12adrenal gland developmentGO:03032510.1NR5A1, WT1

Molecular functions related to Nephroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor bindingGO:00552010.4NOV, CYR61, WISP3, WISP2

Products for genes affiliated with Nephroblastoma

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Sources for Nephroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet