MCID: NPH011
MIFTS: 55

Nephroblastoma malady

Cancer diseases, Nephrological diseases categories
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Summaries for Nephroblastoma

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Wikipedia:65 Wilms\' (/v?lmz/) tumor, Wilms tumor, or nephroblastoma is cancer of the kidneys that typically occurs... more...

MalaCards based summary: Nephroblastoma, also known as renal wilms tumor, is related to wilms tumor and glomerulosclerosis. An important gene associated with Nephroblastoma is NOV (nephroblastoma overexpressed), and among its related pathways are Notch Signaling Pathways and Neural Crest Differentiation. The compounds captopril and ang ii have been mentioned in the context of this disorder. Affiliated tissues include children, kidney and bone, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Disease Ontology:8 A kidney cancer that affects the kidneys and typically located in children.

Description from OMIM:46 194070

Aliases & Classifications for Nephroblastoma

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Nephroblastoma, Aliases & Descriptions:

Name: Nephroblastoma 8 10 62
Renal Wilms Tumor 8 62
Childhood Renal Wilms' Cancer 8
 
Adult Renal Wilms' Tumor 8
Adult Renal Wilms Tumor 62
Adult Nephroblastoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology8 DOID:2154
MeSH34 D009396
OMIM46 194070

Related Diseases for Nephroblastoma

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Graphical network of the top 20 diseases related to Nephroblastoma:



Diseases related to nephroblastoma

Symptoms for Nephroblastoma

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Clinical features from OMIM:

194070

Drugs & Therapeutics for Nephroblastoma

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Drug clinical trials:

Search ClinicalTrials for Nephroblastoma

Search NIH Clinical Center for Nephroblastoma

Genetic Tests for Nephroblastoma

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Anatomical Context for Nephroblastoma

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MalaCards organs/tissues related to Nephroblastoma:

32
Kidney, Bone, Liver, Bone marrow, Spinal cord, Lung, Lymph node, Endothelial, Skeletal muscle, Breast, Skin, Ovary, T cells

FMA organs/tissues related to Nephroblastoma:

14
Children

Animal Models for Nephroblastoma or affiliated genes

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Publications for Nephroblastoma

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Articles related to Nephroblastoma:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
Cystic partially differentiated nephroblastoma: A rare renal tumor. (24339528)
2013
2
Tumor biology influences the prognosis of nephroblastoma patients with primary pulmonary metastases: results from SIOP 93-01/GPOH and SIOP 2001/GPOH. (21670612)
2011
3
Histoclinical study of nephroblastoma in relation to current and previous SIOP Classification of Renal Tumors of Childhood. (21290348)
2010
4
Nephroblastoma is a success of paediatric oncologic therapy. How further can we go?: Results of a cyto-histologic correlation study. (19845033)
2010
5
Anaplastic nephroblastomas express transketolase-like enzyme 1. (19139037)
2009
6
Changes of blood count, lymphocyte subpopulations and immunoglobulin levels in nephroblastoma long term survivors. (19152239)
2009
7
KIT, PDGFRalpha and EGFR analysis in nephroblastoma. (18478259)
2008
8
Malignant nephroblastoma in a common marmoset (Callithrix jacchus). (18192583)
2008
9
Experience and outcomes of nephroblastoma in Johannesburg, 1998 - 2003. (17407020)
2007
10
Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. (17500060)
2007
11
Nephroblastoma in an adult sheep. (17172481)
2006
12
Nephroblastoma with transcoelomic metastasis in a Japanese black bull. (16953095)
2006
13
Parotid carcinoma after autologous bone marrow transplantation for relapsed nephroblastoma. (12902928)
2003
14
Expression of the neurotrophin-receptor TrkB predicts outcome in nephroblastomas: results of a pilot-study]. (11528553)
2001
15
Fetal rhabdomyomatous nephroblastoma: diagnosis by fine-needle aspiration cytology--a case report. (10787144)
2000
16
Nephroblastoma in the adult. (10531576)
1999
17
Fatal hepatic veno-occlusive disease with fibrinolysis as the cause of death during preoperative chemotherapy for nephroblastoma. (9722902)
1998
18
Treatment of nephroblastoma in a juvenile dog. (7649773)
1995
19
Nephroblastoma and end-stage renal failure with bilateral cystic kidneys. (7794714)
1995
20
Hepatotoxicity in irradiated nephroblastoma patients. (7520593)
1994
21
Nephroblastoma (Wilms' tumor): a model system of aberrant renal development. (7809506)
1994
22
Second messengers involved in the control of renin secretion in cultured human nephroblastoma cells. (8184901)
1994
23
Atrial natriuretic peptide suppresses isoprenaline and dibutyryl cyclic adenosine monophosphate-induced cell growth in cultured renin-secreting human nephroblastoma cells. Comparison with forskolin-induced renin secretion. (1317905)
1992
24
Preoperative care of infants with nephroblastoma. The International Society of Pediatric Oncology 6 experience. (1315208)
1992
25
DNA quantitation of Wilms' tumour (nephroblastoma) using flow cytometry and image analysis. (1320635)
1992
26
The histologic, ultrastructural, and immunohistochemical features of a blastema-predominant canine nephroblastoma. (1320304)
1992
27
A cystic partially differentiated nephroblastoma producing alpha-fetoprotein. (1280914)
1992
28
Correlation of the inability to sustain growth in defined serum-free medium with the suppression of tumorigenicity in Wilms' nephroblastoma. (1645741)
1991
29
T-cell lymphoma and mature nephroblastoma after synchronous bilateral Wilms' tumor. (1845941)
1991
30
Hyperdiploidy including trisomy 8 in a cystic partially differentiated nephroblastoma. (2548706)
1989
31
Establishment and characterization of an immature epithelial cell line (ENU-T-1) derived from a rat nephroblastoma. (2575302)
1989
32
Nephroblastoma in an ovotestis of a true hermaphrodite: a case report. (3033335)
1987
33
Sarcomatous Wilms' tumour with clear cells and hyalinization. A study of 38 tumours in children from the SIOP nephroblastoma file. (2448218)
1987
34
Lectin histochemistry of nephroblastoma (Wilms' tumour). (2416712)
1985
35
Inguinal nephroblastoma. (6095522)
1984
36
Synthesis and catabolism of PGE2 by a nephroblastoma associated with hypercalcemia without bone metastases. (6331625)
1984
37
Malignant nephroblastoma in Macaca fascicularis. (6292577)
1982
38
Malignancies associated with renal transplant: first case report of a nephroblastoma occurring in an adult host kidney. (6267326)
1981
39
Fetal rhabdomyomatous nephroblastoma with a renal pelvic mass simulating sarcoma botryoides. (6263119)
1981
40
Nephroblastoma. Results and complications of treatment. (231376)
1979
41
Nephroblastoma. (232096)
1979
42
Cystic partially differentiated nephroblastoma: a clinicopathologic entity in the spectrum of infantile renal neoplasia. (196744)
1977
43
Nephroblastoma: an index reference cancer. (4125626)
1973
44
An approach to metastatic nephroblastoma. (4346274)
1973
45
A nephroblastoma in a fire-bellied newt, Cynops pyrrhogaster. (4321086)
1970
46
Nephrotic syndrome and nephroblastoma. Report of a case. (4295093)
1968
47
Some unusual adult male urogenital tumors with dysontogenetic features. Reports of mesonephroma, MA1llerian carcinosarcoma, transitional cloacogenic carcinoma and nephroblastoma. (4289492)
1967
48
NEPHROBLASTOMA (WILMS' TUMOUR): IMPROVED PROGNOSIS WITH ACTINOMYCIN D. (14176463)
1964
49
CURRENT MANAGEMENT OF NEPHROBLASTOMA AND NEUROBLASTOMA. (14129328)
1964
50
Multiplicity of cell response to the BAI strain A (myeloblastosis) avian tumor virus. II. Nephroblastoma (Wilms' tumor): ultrastructure. (13906058)
1962

Variations for Nephroblastoma

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Expression for genes affiliated with Nephroblastoma

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Expression patterns in normal tissues for genes affiliated with Nephroblastoma

Search GEO for disease gene expression data for Nephroblastoma.

Pathways for genes affiliated with Nephroblastoma

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Pathways related to Nephroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NOV, DLL1
28.8DLL1, TWIST1, LHX1

Compounds for genes affiliated with Nephroblastoma

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Compounds related to Nephroblastoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1captopril44 61 50 28 1113.7CTGF, REN
2ang ii449.7CTGF, REN
3amiloride44 28 1111.6CTGF, REN
4sp 60012544 6110.5CTGF, MAPK8IP1
5losartan44 50 28 1112.3CTGF, REN
6heparin44 28 24 1112.2NRTN, NOV, CTGF

GO Terms for genes affiliated with Nephroblastoma

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Cellular components related to Nephroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6CTGF, NOV, NRTN, DLL1, REN

Biological processes related to Nephroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kidney developmentGO:0018229.6REN, LHX1
2regulation of gene expressionGO:0104689.6LHX1, NOV
3regulation of cell growthGO:0015589.0CTGF, NOV, WISP3
4ossificationGO:0015038.8CTGF, TWIST1
5cell-cell signalingGO:0072678.6LHX1, WISP3, KLF10, DLL1

Molecular functions related to Nephroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor bindingGO:0055208.7CTGF, NOV, WISP3
2growth factor activityGO:0080838.7CTGF, NOV, NRTN, WISP3

Products for genes affiliated with Nephroblastoma

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Sources for Nephroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet