MCID: NPH011
MIFTS: 54

Nephroblastoma malady

Cancer diseases, Nephrological diseases categories

Summaries for Nephroblastoma

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9Disease Ontology, 66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Wilms\' (/v?lmz/) tumor, Wilms tumor, or nephroblastoma is cancer of the kidneys that typically occurs... more...

MalaCards: Nephroblastoma, also known as childhood renal wilms' cancer, is related to wilms tumor and glomerulosclerosis. An important gene associated with Nephroblastoma is NOV (nephroblastoma overexpressed), and among its related pathways are Notch Signaling Pathways and Neural Crest Differentiation. The compounds captopril and ang ii have been mentioned in the context of this disorder. Affiliated tissues include children, kidney and bone, and related mouse phenotypes are endocrine/exocrine gland and renal/urinary system.

Disease Ontology:9 A kidney cancer that affects the kidneys and typically located in children.

Description from OMIM:48 194070

Aliases & Classifications for Nephroblastoma

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9Disease Ontology, 11DISEASES, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt, 48OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

nephroblastoma 9 11 63
childhood renal wilms' cancer 9
adult renal wilms' tumor 9
adult renal wilms tumor 63
adult nephroblastoma 9
renal wilms tumor 9


External Ids:

Disease Ontology9 DOID:2154
MeSH36 D009396
OMIM48 194070

Related Diseases for Nephroblastoma

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18GeneCards, 19GeneDecks
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Diseases related to Nephroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1wilms tumor31.0WISP3, REN, NOV, CTGF
2glomerulosclerosis29.9REN, CTGF
3breast cancer29.6WISP3, TWIST1, KLF10, NOV, CTGF
4neuroblastoma10.5
5renal wilms' tumor10.4
6hepatitis10.3
7hypertension10.3
8renal cell carcinoma10.2
9rhabdomyosarcoma10.2
10cystic nephroma10.2
11aniridia10.2
12blastema predominant kidney wilms' tumor10.1
13epithelial predominant wilms' tumor10.1
14stromal predominant kidney wilms' tumor10.1
15mixed cell type kidney wilms' tumor10.1
16hypercalcemia10.1
17sarcoma10.1
18germ cell tumors10.1
19teratoma10.1
20hereditary wilms' tumor10.0
21neuronitis10.0
22metanephric adenoma10.0
23fanconi's anemia10.0
24denys-drash syndrome10.0
25cystic kidney10.0
26glomerulonephritis10.0
27nephrotic syndrome10.0
28horseshoe kidney10.0
29wilms tumor, type 110.0
30testicular germ cell tumor10.0
31nephritis10.0
32mesoblastic nephroma10.0
33endotheliitis10.0
34renal dysplasia10.0
35renal fibrosis10.0CTGF, REN
36primary hyperoxaluria10.0CTGF, REN
37pancreatic cancer9.9CTGF, TWIST1
38neurofibromatosis9.9
39cloacogenic carcinoma9.9
40blastoma9.9
41langerhans-cell histiocytosis9.9
42cervical wilms' tumor9.9
43ovarian wilms' cancer9.9
44portal hypertension9.9
45alagille syndrome9.9
46childhood multilocular cystic kidney neoplasm9.9
47alveolar rhabdomyosarcoma9.9
48beckwith-wiedemann syndrome9.9
49end stage renal failure9.9
50malignant cystic nephroma9.9

Graphical network of the top 20 diseases related to Nephroblastoma:



Diseases related to nephroblastoma

Symptoms for Nephroblastoma

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48OMIM
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Clinical features from OMIM:

194070

Drugs & Therapeutics for Nephroblastoma

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Nephroblastoma

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Anatomical Context for Nephroblastoma

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34MalaCards, 15FMA
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MalaCards organs/tissues related to Nephroblastoma:

34
Kidney, Bone, Liver, Bone marrow, Spinal cord, Lymph node, Lung, Endothelial, Skeletal muscle, Breast, Skin, Ovary, T cells

FMA organs/tissues related to Nephroblastoma:

15
Children

Animal Models for Nephroblastoma or affiliated genes

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38MGI
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Publications for Nephroblastoma

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53PubMed
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Articles related to Nephroblastoma:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Cystic partially differentiated nephroblastoma: A rare renal tumor. (24339528)
2013
2
Tumor biology influences the prognosis of nephroblastoma patients with primary pulmonary metastases: results from SIOP 93-01/GPOH and SIOP 2001/GPOH. (21670612)
2011
3
Histoclinical study of nephroblastoma in relation to current and previous SIOP Classification of Renal Tumors of Childhood. (21290348)
2010
4
Nephroblastoma is a success of paediatric oncologic therapy. How further can we go?: Results of a cyto-histologic correlation study. (19845033)
2010
5
Anaplastic nephroblastomas express transketolase-like enzyme 1. (19139037)
2009
6
Changes of blood count, lymphocyte subpopulations and immunoglobulin levels in nephroblastoma long term survivors. (19152239)
2009
7
KIT, PDGFRalpha and EGFR analysis in nephroblastoma. (18478259)
2008
8
Malignant nephroblastoma in a common marmoset (Callithrix jacchus). (18192583)
2008
9
Experience and outcomes of nephroblastoma in Johannesburg, 1998 - 2003. (17407020)
2007
10
Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia. (17500060)
2007
11
Nephroblastoma in an adult sheep. (17172481)
2006
12
Nephroblastoma with transcoelomic metastasis in a Japanese black bull. (16953095)
2006
13
Parotid carcinoma after autologous bone marrow transplantation for relapsed nephroblastoma. (12902928)
2003
14
Expression of the neurotrophin-receptor TrkB predicts outcome in nephroblastomas: results of a pilot-study]. (11528553)
2001
15
Fetal rhabdomyomatous nephroblastoma: diagnosis by fine-needle aspiration cytology--a case report. (10787144)
2000
16
Nephroblastoma in the adult. (10531576)
1999
17
Fatal hepatic veno-occlusive disease with fibrinolysis as the cause of death during preoperative chemotherapy for nephroblastoma. (9722902)
1998
18
Treatment of nephroblastoma in a juvenile dog. (7649773)
1995
19
Nephroblastoma and end-stage renal failure with bilateral cystic kidneys. (7794714)
1995
20
Hepatotoxicity in irradiated nephroblastoma patients. (7520593)
1994
21
Nephroblastoma (Wilms' tumor): a model system of aberrant renal development. (7809506)
1994
22
Second messengers involved in the control of renin secretion in cultured human nephroblastoma cells. (8184901)
1994
23
Atrial natriuretic peptide suppresses isoprenaline and dibutyryl cyclic adenosine monophosphate-induced cell growth in cultured renin-secreting human nephroblastoma cells. Comparison with forskolin-induced renin secretion. (1317905)
1992
24
Preoperative care of infants with nephroblastoma. The International Society of Pediatric Oncology 6 experience. (1315208)
1992
25
DNA quantitation of Wilms' tumour (nephroblastoma) using flow cytometry and image analysis. (1320635)
1992
26
The histologic, ultrastructural, and immunohistochemical features of a blastema-predominant canine nephroblastoma. (1320304)
1992
27
A cystic partially differentiated nephroblastoma producing alpha-fetoprotein. (1280914)
1992
28
Correlation of the inability to sustain growth in defined serum-free medium with the suppression of tumorigenicity in Wilms' nephroblastoma. (1645741)
1991
29
T-cell lymphoma and mature nephroblastoma after synchronous bilateral Wilms' tumor. (1845941)
1991
30
Hyperdiploidy including trisomy 8 in a cystic partially differentiated nephroblastoma. (2548706)
1989
31
Establishment and characterization of an immature epithelial cell line (ENU-T-1) derived from a rat nephroblastoma. (2575302)
1989
32
Nephroblastoma in an ovotestis of a true hermaphrodite: a case report. (3033335)
1987
33
Sarcomatous Wilms' tumour with clear cells and hyalinization. A study of 38 tumours in children from the SIOP nephroblastoma file. (2448218)
1987
34
Lectin histochemistry of nephroblastoma (Wilms' tumour). (2416712)
1985
35
Inguinal nephroblastoma. (6095522)
1984
36
Synthesis and catabolism of PGE2 by a nephroblastoma associated with hypercalcemia without bone metastases. (6331625)
1984
37
Malignant nephroblastoma in Macaca fascicularis. (6292577)
1982
38
Malignancies associated with renal transplant: first case report of a nephroblastoma occurring in an adult host kidney. (6267326)
1981
39
Fetal rhabdomyomatous nephroblastoma with a renal pelvic mass simulating sarcoma botryoides. (6263119)
1981
40
Nephroblastoma. Results and complications of treatment. (231376)
1979
41
Nephroblastoma. (232096)
1979
42
Cystic partially differentiated nephroblastoma: a clinicopathologic entity in the spectrum of infantile renal neoplasia. (196744)
1977
43
Nephroblastoma: an index reference cancer. (4125626)
1973
44
An approach to metastatic nephroblastoma. (4346274)
1973
45
A nephroblastoma in a fire-bellied newt, Cynops pyrrhogaster. (4321086)
1970
46
Nephrotic syndrome and nephroblastoma. Report of a case. (4295093)
1968
47
Some unusual adult male urogenital tumors with dysontogenetic features. Reports of mesonephroma, MA1llerian carcinosarcoma, transitional cloacogenic carcinoma and nephroblastoma. (4289492)
1967
48
NEPHROBLASTOMA (WILMS' TUMOUR): IMPROVED PROGNOSIS WITH ACTINOMYCIN D. (14176463)
1964
49
CURRENT MANAGEMENT OF NEPHROBLASTOMA AND NEUROBLASTOMA. (14129328)
1964
50
Multiplicity of cell response to the BAI strain A (myeloblastosis) avian tumor virus. II. Nephroblastoma (Wilms' tumor): ultrastructure. (13906058)
1962

Variations for Nephroblastoma

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Expression for genes affiliated with Nephroblastoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephroblastoma

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Pathways for genes affiliated with Nephroblastoma

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51PathCards, 55R&D Systems, 39NCBI BioSystems Database
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Pathways related to Nephroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NOV, DLL1
28.8DLL1, TWIST1, LHX1

Compounds for genes affiliated with Nephroblastoma

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46Novoseek, 62Tocris Bioscience, 52PharmGKB, 30IUPHAR, 12DrugBank, 25HMDB
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Compounds related to Nephroblastoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1captopril46 62 52 30 1213.7CTGF, REN
2ang ii469.7CTGF, REN
3amiloride46 30 1211.6CTGF, REN
4sp 60012546 6210.5CTGF, MAPK8IP1
5losartan46 52 30 1212.3CTGF, REN
6heparin46 30 25 1212.2NRTN, NOV, CTGF

GO Terms for genes affiliated with Nephroblastoma

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17Gene Ontology
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Cellular components related to Nephroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6CTGF, NOV, NRTN, DLL1, REN

Biological processes related to Nephroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kidney developmentGO:0018229.6REN, LHX1
2regulation of gene expressionGO:0104689.6NOV, LHX1
3regulation of cell growthGO:0015589.0WISP3, NOV, CTGF
4ossificationGO:0015038.8CTGF, TWIST1
5cell-cell signalingGO:0072678.6KLF10, DLL1, WISP3, LHX1

Molecular functions related to Nephroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor bindingGO:0055208.7CTGF, NOV, WISP3
2growth factor activityGO:0080838.7CTGF, NOV, NRTN, WISP3

Products for genes affiliated with Nephroblastoma

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Sources for Nephroblastoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet