MCID: NPH003
MIFTS: 47

Nephrocalcinosis malady

Categories: Rare diseases, Metabolic diseases, Nephrological diseases

Aliases & Classifications for Nephrocalcinosis

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Aliases & Descriptions for Nephrocalcinosis:

Name: Nephrocalcinosis 11 46 13 25 48 37 66
 
Hypercalcemic Nephropathy 46 66

Classifications:



External Ids:

Disease Ontology11 DOID:12679
MeSH37 D009397
NCIt43 C84918

Summaries for Nephrocalcinosis

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NIH Rare Diseases:46 Nephrocalcinosis is a disorder in which there is excess calcium deposited in the kidneys. it is relatively common in premature infants. individuals may be asymptomatic or have symptoms related to the condition causing nephrocalcinosis. if kidney stones are present, an individual may have blood in the urine; fever and chills; nausea and vomiting; or severe pain in the belly area, sides of the back (flank), groin, or testicles. later symptoms related to nephrocalcinosis may be associated with chronic kidney failure. it may be caused by use of certain medications or supplements; infection; or any condition that leads to high levels of calcium in the blood or urine including hyperparathyroidism, renal tubular acidosis, alport syndrome, bartter syndrome, and a variety of other conditions. some of the underlying disorders that can cause nephrocalcinosis are genetic, with the inheritance pattern depending on the specific disorder. the goal of treatment is to reduce symptoms and prevent more calcium from being deposited in the kidneys. last updated: 2/24/2011

MalaCards based summary: Nephrocalcinosis, also known as hypercalcemic nephropathy, is related to hypophosphatemic rickets and proteinuria, low molecular weight, with hypercalciuric nephrocalcinosis. An important gene associated with Nephrocalcinosis is CLDN16 (Claudin 16), and among its related pathways are Glycine, serine and threonine metabolism and Glyoxylate and dicarboxylate metabolism. Affiliated tissues include kidney, bone and thyroid, and related mouse phenotypes are skeleton and renal/urinary system.

Wikipedia:69 Nephrocalcinosis, once known as Albright\'s calcinosis after Fuller Albright, or Anderson-Carr kidneys,... more...

Related Diseases for Nephrocalcinosis

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Diseases related to Nephrocalcinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1hypophosphatemic rickets30.3CLCN5, CLDN16, OCRL, SLC12A1
2proteinuria, low molecular weight, with hypercalciuric nephrocalcinosis12.1
3amelogenesis imperfecta nephrocalcinosis12.1
4familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis11.9
5dent disease11.7
6hypomagnesemia 3, renal11.4
7amelogenesis imperfecta, type ig11.4
8hypomagnesemia 5, renal, with ocular involvement11.3
9blue diaper syndrome11.3
10amelogenesis imperfecta hypoplastic type, ig11.0
11hypogonadism-cataract syndrome10.8
12lubinsky syndrome10.8
13primary hypomagnesemia10.8
14bestrophinopathy10.4CLCN5, SLC12A1
15renal tubular acidosis10.4
16short syndrome10.4
17apparent mineralocorticoid excess10.3
18nephrolithiasis10.3
19hypercalcemia10.3
20nystagmus 1, congenital, x-linked10.2CLCN5, OCRL
21rickets10.2
22primary hyperoxaluria10.1
23amelogenesis imperfecta10.1
24hyperparathyroidism10.1
25star syndrome10.1CLCN5, OCRL
26lacrimal gland adenocarcinoma10.1AGXT, GRHPR
27amniotic band syndrome10.1CLCN5, OCRL
28nephrotic syndrome10.0
29hypocalcemia, autosomal dominant10.0
30down syndrome10.0
31kidney papillary necrosis10.0AGXT, GRHPR
32cystic fibrosis10.0
33hypophosphatemia10.0
34sideroblastic anemia with b-cell immunodeficiency, periodic fevers, and developmental delay9.9
35hypomagnesemia 1, intestinal9.9
36renal tubular acidosis, distal, ar9.9
37hypercalcemia, infantile9.9
38nephrolithiasis, type i9.9
39dent disease 29.9
40anorexia nervosa9.9
41glucose/galactose malabsorption9.9
42primary hyperparathyroidism9.9
43thyroiditis9.9
44diabetes insipidus9.9
45medullary sponge kidney9.9
46hypoparathyroidism9.8
47hypokalemia9.8
48kidney disease9.8
49calabro syndrome9.8ATP6V0A4, ATP6V1B1
50renal tubular acidosis with deafness9.8

Graphical network of the top 20 diseases related to Nephrocalcinosis:



Diseases related to nephrocalcinosis

Symptoms for Nephrocalcinosis

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Drugs & Therapeutics for Nephrocalcinosis

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Drugs for Nephrocalcinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Citric AcidPhase 3106377-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
2beta-endorphinPhase 2, Phase 3117
3
Potassium CitratePhase 323
Synonyms:
 
tripotassium citrate
4
HydrochlorothiazidePhase 2, Phase 339858-93-53639
Synonyms:
125727-50-6
3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothi
3,4-Dihydrochlorothiazide
58-93-5
6-Chloro-7-sulfamoyl-3, 4-dihy
8049-49-8
AB00052012
AC-11072
AC1L1GDT
AC1Q55FM
AF-614/30832002
AKOS000121373
ARONIS24316
Acesistem
Acuilix
Acuretic
Aldactazide
Aldactazide 25/25
Aldazida
Aldectazide 50/50
Aldoril
Ambap58-93-5
Apo-Hydro
Apresazide
Aquarills
Aquarius
Aquazide H
Aquazide-H
BAS 00371709
BIDD:GT0153
BPBio1_000019
BRD-K13078532-001-05-2
BRN 0625101
BSPBio_000017
BSPBio_002132
Bio-0714
Bremil
Briazide
C7H8ClN3O4S2
CAS-58-93-5
CCRIS 2082
CHEMBL435
CID3639
CPD000035778
Caplaril
Capozide
Carozide
Catiazida
Chlorizide
Chlorosulthiadil
Chlorothiazide
Chlorsulfonamidodihydrobenzothiadiazine dioxide
Chlorzide
Chlothia
Cidrex
Clorana
Component of Butizide Prestabs
Concor Plus
Condiuren
D00340
D006852
DB00999
Diaqua
Dichlorosal
Dichlorotride
Dichlothiazide
Dichlotiazid
Dichlotride
Diclotride
Dicyclotride
Didral
Dihydran
Dihydrochlorothiazid
Dihydrochlorothiazide
Dihydrochlorothiazidum
Dihydrochlorurit
Dihydrochlorurite
Dihydroxychlorothiazidum
Direma
Disalunil
Disothiazid
Diu 25 Vigt
Diu-Melusin
Diu-melusin
Diuril
Diurogen
DivK1c_000289
Dixidrasi
Drenol
Dyazide
EINECS 200-403-3
EU-0100614
Esidrex
Esidrix
Esidrix (TN)
Esimil
Esoidrina
FT-0082750
Fluvin
H 4759
H1274
H2910_SIAL
H4759_SIAL
HCT
HCT-Isis
HCTZ
HCZ
HMS1568A19
HMS1920D19
HMS2091L05
HMS500O11
HMS553N04
HSDB 3096
Hidril
Hidro-Niagrin
Hidrochlortiazid
Hidroclorotiazida
Hidroclorotiazida [INN-Spanish]
Hidroronol
Hidrosaluretil
Hidrotiazida
Hyclosid
Hydrex-semi
Hydril
Hydro Par
Hydro-Aquil
Hydro-D
Hydro-Diuril
Hydro-Saluric
Hydro-T
Hydro-chlor
HydroDIURIL
Hydrochlorat
Hydrochloro Thiazide
Hydrochlorot
Hydrochlorothiazid
Hydrochlorothiazide
Hydrochlorothiazide (JP15/USP/INN)
Hydrochlorothiazide Intensol
Hydrochlorothiazide [INN:BAN:JAN]
 
Hydrochlorothiazidum
Hydrochlorothiazidum [INN-Latin]
Hydrochlorthiazide
Hydrochlorthiazidum
Hydrocot
Hydrodiuretic
Hydrodiuril
Hydropres
Hydrosaluric
Hydrothide
Hydrozide
Hydrozide Injection, Veterinary
Hypothiazid
Hypothiazide
Hytrid
Hyzaar
I09-0531
IDI1_000289
Idroclorotiazide
Idroclorotiazide [DCIT]
Idrotiazide
Inderide
Inderide 80/25
Indroclor
Ivaugan
Jen-Diril
KBio1_000289
KBio2_001357
KBio2_003925
KBio2_006493
KBio3_001352
KBioGR_000351
KBioSS_001357
LS-243
Lopac-H-4759
Lopac0_000614
Lopressor HCT
Lotensin HCT
Lotensin Hct
MLS000069619
Manuril
Maschitt
Maxzide
Maybridge Compound 10
Maybridge1_004336
Mazide 25 mg
Medozide
Megadiuril
Microzide
Microzide (TN)
Mictrin
Mikorten
Modurcen
Moduretic
MolPort-000-144-465
NCGC00015508-01
NCGC00015508-02
NCGC00015508-03
NCGC00015508-07
NCGC00015508-12
NCGC00021906-03
NCGC00021906-04
NCGC00021906-05
NCGC00021906-06
NCGC00021906-07
NCGC00021906-08
NCI-C55925
NCI60_004317
NINDS_000289
NSC 53477
NSC53477
Natrinax
Nefrix
Nefrol
Neo-Codema
Neo-Flumen
Neo-Minzil
Neo-codema
Neoflumen
Newtolide
Novodiurex
Oprea1_357174
Oretic
Pantemon
Panurin
Prestwick0_000009
Prestwick1_000009
Prestwick2_000009
Prestwick3_000009
Prestwick_263
Prinzide
Raunova Plus
Ro-Hydrazide
Ro-hydrazide
Roxane
S1708_Selleck
SAM002554901
SMR000035778
SPBio_001259
SPBio_001938
SPECTRUM1500335
STK315354
Saldiuril
Sectrazide
Selozide
Ser-Ap-Es
Servithiazid
Spectrum2_001040
Spectrum3_000456
Spectrum4_000006
Spectrum5_000824
Spectrum_000877
Spironazide
Su 5879
Tandiur
Thiaretic
Thiuretic
Thlaretic
Timolide
UNII-0J48LPH2TH
Unazid
Unipres
Urodiazin
Urozide
Vaseretic
Vetidrex
WLN: T66 BSWM EM DHJ HG ISZW
ZINC00896569
Ziac
Zide
adiazine-1,1-dioxide
component of Aldactazide
component of Aldoril
component of Caplaril
component of Cyclex
component of Dyazide
component of Esimil
diclot ride
dro-2H-1,2,4-benzothiadiazine 1,1-dioxide
hydrochlorothiazide
panurin dichloride
5diureticsPhase 3, Phase 21338
6CitrateNutraceuticalPhase 31063
7potassium phosphatePhase 1, Phase 211
8
TeriparatidePhase 213052232-67-416133850
Synonyms:
52232-67-4
D06078
Forteo
Forteo (TN)
 
TERIPARATIDE
Teriparatide (USAN/INN)
Teriparatide (genetical recombination)
Teriparatide (genetical recombination) (JAN)
Teriparatide recombinant human
9
AlfacalcidolPhase 25041294-56-85282181
Synonyms:
(5Z,7e)-9,10-Seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol
1-Hydroxycholecalciferol
1-hydroxycholecalciferol
1alpha-Hydroxy-vitamin D3
 
1alpha-hydroxycholecalciferol
1alpha-hydroxyvitamin D3
9,10-Secocholesta-5,7,10(19)-triene-1alpha,3beta-diol
Alfacalcidolum
Alsiodol
10
AmiloridePhase 2502016-88-8, 2609-46-316231
Synonyms:
17440-83-4 (hydrochloride)
1f5l
2016-88-8 (anhydrous hydrochloride)
2609-46-3
3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide
3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide
3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
AB00053415
AC-13631
AC1L27IZ
AC1Q3POC
AMILORIDE
AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8))
Amiclaran
Amiclaran (TN)
Amikal (Hydrochloride dihydrate)
Amilorid
Amilorida
Amilorida [INN-Spanish]
Amiloride (INN)
Amiloride HCL
Amiloride [INN:BAN]
Amiloride hydrochloride hydrate
Amiloridum
Amiloridum [INN-Latin]
Amipramidin
Amipramidine
Amipramizid
Amipramizide
Amiprazidine
Amyloride
BCBcMAP01_000101
BIDD:GT0466
BPBio1_000015
BRD-K97181089-003-02-3
BRD-K97181089-310-03-0
BSPBio_000013
BSPBio_001572
BSPBio_001826
Bio1_000359
Bio1_000848
Bio1_001337
Bio2_000292
Bio2_000772
C06821
C6H8ClN7O
CCRIS 6545
CHEBI:2639
CHEMBL945
CID16231
CPD-10324
D07447
DB00594
DivK1c_000182
EINECS 220-024-7
Guanamprazin
 
Guanamprazine
HMS1791O14
HMS1989O14
HMS2089H05
IDI1_000182
IDI1_034042
KBio1_000182
KBio2_000292
KBio2_000394
KBio2_002860
KBio2_002962
KBio2_005428
KBio2_005530
KBio3_000583
KBio3_000584
KBio3_001326
KBioGR_000292
KBioGR_000544
KBioSS_000292
KBioSS_000394
LS-1094
Lopac-A-7410
Lopac0_000111
MK-870 (Hydrochloride dihydrate)
MLS000758249
MLS001060798
Midamor
Midamor (Hydrochloride dihydrate)
MolPort-005-934-472
MolPort-005-937-651
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide
N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid
N-amidino-3,5-diamino-6-chloropyrazinecarboxamide
NCGC00015089-01
NCGC00015089-02
NCGC00015089-12
NCGC00024443-02
NCGC00024443-05
NCGC00024443-06
NCGC00024443-07
NCGC00024443-09
NINDS_000182
Prestwick0_000007
Prestwick1_000007
Prestwick2_000007
Prestwick3_000007
Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride
SMR000449325
SMR000486264
SPBio_000136
SPBio_001934
ST079279
Spectrum2_000118
Spectrum3_000293
Spectrum4_000132
Spectrum5_000776
Spectrum_000034
Tocris-0890
UNII-7DZO8EB0Z3
ZINC04340269
11
Magnesium Sulfate1597487-88-924083
Synonyms:
(C10-C16) Alkylalcohol sulfuric acid, magnesium salt
00627_FLUKA
10028-26-9
10034-99-8 (heptahydrate)
13143_RIEDEL
13143_SIAL
139939-75-6
18939-43-0
203726_ALDRICH
208094_SIAL
34276_FLUKA
34276_RIEDEL
38146_FLUKA
38146_RIEDEL
63126_FLUKA
63136_FLUKA
63136_SIAL
63139_FLUKA
63139_SIAL
68081-97-0
7487-88-9
AC1L2N76
AC1LAX36
AC1Q1U66
AI3-02029
Bitter salt
C10-C16 Alkyl alcohol sulfuric acid magnesium salt
CCRIS 8411
CHEBI:32599
CID24083
CPD0-2390
Caswell No. 534
D008278
DB00653
EINECS 231-298-2
EINECS 233-073-4
EINECS 242-691-3
EINECS 268-365-0
EPA Pesticide Chemical Code 050503
Epsom salt
HSDB 664
Hair salt
Heptahydrate Magnesium Sulfate
Kieserite [as monohydrate]
LS-88605
M2643_SIGMA
M3409_SIGMA
 
M7506_SIAL
M8150_SIGMA
MAGNESIUM SULFATE
Magnesium Sulfate In Plastic Container
Magnesium Sulfate, Heptahydrate
Magnesium Sulphate Hydrate
Magnesium bisulfate
Magnesium hydrogensulphate
Magnesium sulfate
Magnesium sulfate (1:1)
Magnesium sulfate anhydrous
Magnesium sulfate dried
Magnesium sulfate heptahydrate
Magnesium sulfate hexahydrate
Magnesium sulfate in dextrose 5% in plastic container
Magnesium sulfate solution
Magnesium sulphate
Magnesium sulphate anhydrous
Magnesium sulphate dried
Magnesium sulphate heptahydrate
Magnesium(II) sulfate
Magnesium(ii) sulfate
Magnesiumsulfat
MgSO4
MolPort-003-925-000
NSC 146179
OT-S
OT-S (drying agent)
SDA 15-062-07
Sal Angalis
Sal De sedlitz
Sal amarum
Sal anglicum
Sal catharticum
Sal seidlitense
Salts of england
Sel d'angleterre
Sulfate, Magnesium
Sulfuric acid magnesium salt
Sulfuric acid magnesium salt (1:1)
Sulfuric acid magnesium salt (VAN)
Sulfuric acid, C10-16 alkyl ester, magnesium salt
Sulfuric acid, magnesium salt
Sulfuric acid, magnesium salt (1:1)
Sulfuric acid, mono-C10-16-alkyl esters, magnesium salts
Tomix OT
UNII-DE08037SAB
UNII-ML30MJ2U7I
magnesium(2+) ion sulfate
12calcium channel blockers1889

Interventional clinical trials:

(show all 13)
idNameStatusNCT IDPhase
1Alkaline Citrate Treatment to Lower the Risk of Nephrocalcinosis in Preterm InfantsCompletedNCT00249951Phase 3
2Effects of PTH Replacement on Bone in HypoparathyroidismActive, not recruitingNCT00395538Phase 3
3Study to Assess the Efficacy and Safety of Oral Potassium Citrate on the Prevention of Nephrocalcinosis in Extreme PrematureNot yet recruitingNCT01756547Phase 3
4ACTHAR GEL for Sarcoidosis-Associated Calcium Dysregulation: An Open-label Pilot StudyNot yet recruitingNCT02155803Phase 2, Phase 3
5Dose-Dependent Effect of Thiazide in Dent's Disease HypercalciuriaTerminatedNCT00638482Phase 2, Phase 3
6Role Of Phosphorus And FGF 23 In Patients With Dent DiseaseRecruitingNCT02016235Phase 1, Phase 2
7Recombinant Human rhPTH(1-34) VS Association Alfacalcidol/Hydrochlorothiazide in Autosomal Dominant HypocalcemiaNot yet recruitingNCT02824718Phase 2
8Preterm Infants and NephrocalcinosisRecruitingNCT02438267
9Renal Tubular Acidosis in Incident Renal Transplant RecipientsRecruitingNCT01283880
10Randall's Plaque Study: Pathogenesis and Relationship to NephrolithiasisRecruitingNCT00169806
11Search for New Genetic Causes of Hypercalcemia by Massively Parallel Sequencing of a Genes PanelRecruitingNCT02908542
12Effect of Magnesium Sulfate Infusion Rate on Magnesium Retention in Critically Ill PatientsTerminatedNCT01426165
13International Registry for Primary HyperoxaluriaWithdrawnNCT00875823

Search NIH Clinical Center for Nephrocalcinosis


Cochrane evidence based reviews: nephrocalcinosis

Genetic Tests for Nephrocalcinosis

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Genetic tests related to Nephrocalcinosis:

id Genetic test Affiliating Genes
1 Nephrocalcinosis25

Anatomical Context for Nephrocalcinosis

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MalaCards organs/tissues related to Nephrocalcinosis:

34
Kidney, Bone, Thyroid, Liver, Heart, T cells, Testes

Animal Models for Nephrocalcinosis or affiliated genes

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MGI Mouse Phenotypes related to Nephrocalcinosis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053907.8ATP6V0A4, ATP6V1B1, CLCN5, CYP24A1, FAM20A, SLC12A1
2MP:00053675.4AGXT, ATP6V0A4, ATP6V1B1, CLCN5, CLDN16, CYP24A1
3MP:00053765.4AGXT, ATP6V0A4, ATP6V1B1, CLCN5, CLDN16, CLDN19

Publications for Nephrocalcinosis

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Articles related to Nephrocalcinosis:

(show top 50)    (show all 559)
idTitleAuthorsYear
1
Nephrocalcinosis and Renal Failure in Lesch-Nyhan Syndrome: Report of Two Familial Cases and Review of the Literature. (27079129)
2016
2
Risk factors affecting the development of nephrocalcinosis, the most common complication of hypophosphatemic rickets. (26203600)
2015
3
Lots of steroids and vitamins, tons of complications. Hypercalcemia and nephrocalcinosis as important complications of performance-enhancing drugs. (26474528)
2015
4
Nephrocalcinosis in primary SjAPgren's syndrome. (25852876)
2014
5
Genetic modulation of nephrocalcinosis in mouse models of ectopic mineralization: the Abcc6(tm1Jfk) and Enpp1(asj) mutant mice. (24732453)
2014
6
Ocular involvement in a child with medullary nephrocalcinosis. (22760414)
2013
7
Lanthanum carbonate inhibits intestinal oxalate absorption and prevents nephrocalcinosis after oxalate loading in rats. (23228382)
2013
8
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis in three siblings having the same genetic lesion but different clinical presentations. (21633858)
2012
9
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis: phenotype-genotype correlation and outcome in 32 patients with CLDN16 or CLDN19 mutations. (22422540)
2012
10
Furosemide-associated nephrocalcinosis and renal cysts. (21841841)
2011
11
Incomplete distal renal tubular acidosis with nephrocalcinosis. (22247918)
2011
12
Localization and mechanism of nephrocalcinosis in pseudo-Bartter's syndrome. (20393494)
2010
13
Nephrocalcinosis in preterm neonates. (18797936)
2010
14
Nephrocalcinosis in very low birth weight infants. (20228514)
2010
15
Hyperoxaluria is reduced and nephrocalcinosis prevented with an oxalate-degrading enzyme in mice with hyperoxaluria. (18698135)
2009
16
The relationship of amelogenesis imperfecta and nephrocalcinosis syndrome. (19680205)
2009
17
Nephrocalcinosis and disordered calcium metabolism in two children with SHORT syndrome. (18384141)
2008
18
Nephrocalcinosis in phosphate nephropathy following oral phosphate purgative: a role for underlying subclinical primary hyperparathyroidism? (18037110)
2007
19
A 3-year-old child with proteinuria and nephrocalcinosis. Suspicion of Dent disease. (15365802)
2004
20
Nephrocalcinosis: molecular insights into calcium precipitation within the kidney. (15027893)
2004
21
Development of nephrocalcinosis in very low birth weight infants. (15054644)
2004
22
Nephrocalcinosis in a patient with secondary hyperoxaluria. (15102977)
2004
23
Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis maps to chromosome 3q27 and is associated with mutations in the PCLN-1 gene. (10878661)
2000
24
Oxalosis with nephrocalcinosis. (10607783)
2000
25
Ultrasonographic features of nephrocalcinosis in preterm neonates. (11144796)
2000
26
Oxalate nephrocalcinosis in renal tubular dysgenesis. (10671031)
1999
27
The role of renal chloride channel mutations in kidney stone disease and nephrocalcinosis. (9690036)
1998
28
Nephrocalcinosis in a patient with primary hyperoxaluria type 2. (8865239)
1996
29
Nephrocalcinosis in newborn. (7793250)
1995
30
Medullary nephrocalcinosis: sonographic findings in adult patients. (7756819)
1995
31
Nephrocalcinosis in X-linked hypophosphatemia: effect of treatment versus disease. (7794712)
1995
32
Acetazolamide-induced nephrocalcinosis. (7950830)
1994
33
Renal function in hyperparathyroidism with complicating nephrocalcinosis. (8453206)
1993
34
Bilateral spontaneous steinstrasse and nephrocalcinosi associated with distal renal tubular acidosis. (8326580)
1993
35
Commercial rodent diets and nephrocalcinosis in weanling female rats. (1857094)
1991
36
Hydration monitoring in the long-term prophylaxis of nephrocalcinosis. (1843624)
1991
37
Ultrasound demonstration of nephrocalcinosis in William's syndrome. (2506251)
1989
38
Microscopic nephrocalcinosis in cystic fibrosis. (2911329)
1989
39
Influence of dietary calcium:phosphorus ratio on mineral excretion and nephrocalcinosis in female rats. (3183767)
1988
40
Urolithiasis and nephrocalcinosis in xylitol- and sorbitol-fed male mice of two different strains. (3938806)
1985
41
The effects of parathyroidectomy on the development of nephrocalcinosis in rats fed phosphate-supplemented and unsupplemented diets containing alpha protein. (6684887)
1983
42
Environmental zinc and cadmium pollution associated with generalized osteochondrosis, osteoporosis, and nephrocalcinosis in horses. (7056680)
1982
43
Nephrocalcinosis in angioimmunoblastic lymphadenopathy. A case report. (7102371)
1982
44
The influence of dietary magnesium on reduction of nephrocalcinosis in rats fed purified diet. (7176523)
1982
45
Nephrocalcinosis and nephrolithiasis in children. (627116)
1978
46
Prevention by thyroxine of nephrocalcinosis in early magnesium deficiency in the rat. (4258450)
1972
47
Medullary sponge kidney in the radiological differential diagnosis of nephrocalcinosis. (5587802)
1967
48
EXPERIMENTAL NEPHROCALCINOSIS. A BIOCHEMICAL AND MORPHOLOGIC STUDY. (14260243)
1965
49
NEPHROCALCINOSIS IN CREATINISM. (14326458)
1965
50
MASSIVE CALCIFICATION OF THE MYOCARDIUM. A REPORT OF TWO CASES, ONE ASSOCIATED WITH NEPHROCALCINOSIS. (14206189)
1964

Variations for Nephrocalcinosis

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Expression for genes affiliated with Nephrocalcinosis

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Search GEO for disease gene expression data for Nephrocalcinosis.

Pathways for genes affiliated with Nephrocalcinosis

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Pathways related to Nephrocalcinosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6AGXT, GRHPR
29.6AGXT, GRHPR
3
Show member pathways
9.6AGXT, GRHPR
4
Show member pathways
9.2ATP6V0A4, ATP6V1B1, SLC4A1
5
Show member pathways
8.5ATP6V0A4, ATP6V1B1, CLCN5, SLC12A1, SLC4A1

GO Terms for genes affiliated with Nephrocalcinosis

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Cellular components related to Nephrocalcinosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1vacuolar proton-transporting V-type ATPase complexGO:001647110.1ATP6V0A4, ATP6V1B1
2peroxisomal matrixGO:000578210.1AGXT, GRHPR
3basolateral plasma membraneGO:00163239.9ATP6V1B1, CLDN19, SLC4A1
4extracellular exosomeGO:00700626.9ATP6V0A4, ATP6V1B1, FAM20A, GRHPR, OCRL, SLC12A1

Biological processes related to Nephrocalcinosis according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesion via plasma membrane cell-adhesion moleculesGO:001633810.2CLDN16, CLDN19
2phagosome acidificationGO:009038310.0ATP6V0A4, ATP6V1B1
3proton transportGO:001599210.0ATP6V0A4, ATP6V1B1
4ATP hydrolysis coupled proton transportGO:001599110.0ATP6V0A4, ATP6V1B1
5regulation of pHGO:00068859.8ATP6V0A4, ATP6V1B1
6chloride transmembrane transportGO:19024769.8CLCN5, SLC12A1, SLC4A1
7calcium ion homeostasisGO:00550749.6ATP6V1B1, FAM20A
8glyoxylate metabolic processGO:00464879.5AGXT, GRHPR
9transferrin transportGO:00335729.5ATP6V0A4, ATP6V1B1
10excretionGO:00075888.9ATP6V0A4, ATP6V1B1, CLCN5, CLDN16, GRHPR
11ion transmembrane transportGO:00342208.5ATP6V0A4, ATP6V1B1, CLCN5, SLC12A1

Sources for Nephrocalcinosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet