MCID: NPH003
MIFTS: 48

Nephrocalcinosis malady

Categories: Rare diseases, Metabolic diseases, Nephrological diseases

Aliases & Classifications for Nephrocalcinosis

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Aliases & Descriptions for Nephrocalcinosis:

Name: Nephrocalcinosis 11 48 27 50 39 13 68
 
Hypercalcemic Nephropathy 48 68

Classifications:



External Ids:

Disease Ontology11 DOID:12679
MeSH39 D009397
NCIt45 C84918

Summaries for Nephrocalcinosis

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NIH Rare Diseases:48 Nephrocalcinosis is a disorder that occurs when too much calcium is deposited in the kidneys. it commonly occurs in premature infants. individuals may not have symptoms or may have symptoms related to the condition causing nephrocalcinosis. if kidney stones are present, symptoms may include blood in the urine, fever and chills, nausea and vomiting, and severe pain in the belly area, sides of the back (flank), groin, or testicles. later symptoms may be associated with chronic kidney failure. it may be caused by use of certain medications or supplements, infection, or any condition that leads to high levels of calcium in the blood or urine including hyperparathyroidism, renal tubular acidosis, alport syndrome, bartter syndrome, and a variety of other conditions. some of the underlying disorders that can cause nephrocalcinosis are genetic, with the inheritance pattern depending on the specific disorder. treatment differs depending on the cause of nephrocalcinosis and often aims to prevent more calcium from being deposited in the kidneys. last updated: 4/17/2017

MalaCards based summary: Nephrocalcinosis, also known as hypercalcemic nephropathy, is related to hypophosphatemic rickets and interstitial nephritis. An important gene associated with Nephrocalcinosis is CLDN16 (Claudin 16), and among its related pathways are Glycine, serine and threonine metabolism and Glyoxylate metabolism and glycine degradation. Affiliated tissues include kidney, bone and thyroid, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and homeostasis/metabolism.

Wikipedia:71 Nephrocalcinosis, once known as Albright\'s calcinosis after Fuller Albright, or Anderson-Carr kidneys,... more...

Related Diseases for Nephrocalcinosis

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Diseases related to Nephrocalcinosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 149)
idRelated DiseaseScoreTop Affiliating Genes
1hypophosphatemic rickets31.7CLCN5, CLCNKB, CLDN16, SLC12A1
2interstitial nephritis29.4CLCN5, SLC34A1
3proteinuria, low molecular weight, with hypercalciuric nephrocalcinosis12.2
4midface hypoplasia, hearing impairment, elliptocytosis, and nephrocalcinosis12.0
5dent disease11.8
6familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis11.7
7blue diaper syndrome11.6
8hypomagnesemia 3, renal11.6
9amelogenesis imperfecta, type ig11.6
10hypomagnesemia 5, renal, with ocular involvement11.4
11short syndrome11.1
12amelogenesis imperfecta hypoplastic type, ig11.0
13apparent mineralocorticoid excess11.0
14hypocalcemia, autosomal dominant10.9
15sideroblastic anemia with b-cell immunodeficiency, periodic fevers, and developmental delay10.8
16hypomagnesemia 1, intestinal10.8
17renal tubular acidosis, distal, ar10.8
18hypercalcemia, infantile10.8
19nephrolithiasis, type i10.8
20dent disease 210.8
21hypogonadism-cataract syndrome10.7
22primary hypomagnesemia10.7
23lubinsky syndrome10.7
24renal tubular acidosis with deafness10.6
25hyperoxaluria, primary, type 110.6
26renal tubular acidosis, distal, autosomal recessive10.6
27hyperoxaluria, primary, type ii10.6
28bartter syndrome, type 210.6
29bartter syndrome, type 110.6
30renal tubular acidosis, distal, ad10.6
31hypocalcemia, autosomal dominant 210.6
32fanconi renotubular syndrome 4, with maturity-onset diabetes of the young10.6
33slc4a1-associated distal renal tubular acidosis10.6
34hypercalcemia, infantile, 210.6
35renal tubular acidosis10.3
36obesity, hyperphagia, and developmental delay10.2CLDN16, CLDN19
37ectopic cushing syndrome10.2CLDN16, CLDN19
38cataract 38, autosomal recessive10.2ATP6V1B1, SLC4A1
39retinal cone dystrophy 110.2ATP6V1B1, SLC4A1
40nephrolithiasis10.2
41hyperaldosteronism, familial, type iii10.1KCNJ1, SLC12A1
42congenital sucrase-isomaltase deficiency with starch intolerance10.1CYP24A1, SLC34A1
43uv-sensitive syndrome10.1AGXT, CLDN16
44deafness, nonsyndromic, modifier 110.1CLCN5, CLDN16, KCNJ1
45rickets10.1
46waardenburg syndrome, type 4b10.1CYP24A1, SLC34A1
47dysphagia lusoria10.1KCNJ1, SLC12A1
48prostate cancer, hereditary, x-linked 210.0CLCN5, SLC34A1
49primary hyperoxaluria10.0
50microphthalmia, isolated, with coloboma 710.0KCNJ1, SLC4A1

Graphical network of the top 20 diseases related to Nephrocalcinosis:



Diseases related to nephrocalcinosis

Symptoms & Phenotypes for Nephrocalcinosis

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GenomeRNAi Phenotypes related to Nephrocalcinosis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-19210.0SLC12A1, SLC34A1, SLC4A1

MGI Mouse Phenotypes related to Nephrocalcinosis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053766.1AGXT, ATP6V1B1, CLCN5, CLCNKB, CLDN16, CLDN19
2MP:00053675.5AGXT, ATP6V1B1, CLCN5, CLCNKB, CLDN16, CYP24A1

Drugs & Therapeutics for Nephrocalcinosis

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Drugs for Nephrocalcinosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 55)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Potassium Citrateapproved, vet_approvedPhase 327
Synonyms:
 
tripotassium citrate
2
Hydrochlorothiazideapproved, vet_approvedPhase 2, Phase 341358-93-53639
Synonyms:
125727-50-6
3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothi
3,4-Dihydrochlorothiazide
58-93-5
6-Chloro-7-sulfamoyl-3, 4-dihy
8049-49-8
AB00052012
AC-11072
AC1L1GDT
AC1Q55FM
AF-614/30832002
AKOS000121373
ARONIS24316
Acesistem
Acuilix
Acuretic
Aldactazide
Aldactazide 25/25
Aldazida
Aldectazide 50/50
Aldoril
Ambap58-93-5
Apo-Hydro
Apresazide
Aquarills
Aquarius
Aquazide H
Aquazide-H
BAS 00371709
BIDD:GT0153
BPBio1_000019
BRD-K13078532-001-05-2
BRN 0625101
BSPBio_000017
BSPBio_002132
Bio-0714
Bremil
Briazide
C7H8ClN3O4S2
CAS-58-93-5
CCRIS 2082
CHEMBL435
CID3639
CPD000035778
Caplaril
Capozide
Carozide
Catiazida
Chlorizide
Chlorosulthiadil
Chlorothiazide
Chlorsulfonamidodihydrobenzothiadiazine dioxide
Chlorzide
Chlothia
Cidrex
Clorana
Component of Butizide Prestabs
Concor Plus
Condiuren
D00340
D006852
DB00999
Diaqua
Dichlorosal
Dichlorotride
Dichlothiazide
Dichlotiazid
Dichlotride
Diclotride
Dicyclotride
Didral
Dihydran
Dihydrochlorothiazid
Dihydrochlorothiazide
Dihydrochlorothiazidum
Dihydrochlorurit
Dihydrochlorurite
Dihydroxychlorothiazidum
Direma
Disalunil
Disothiazid
Diu 25 Vigt
Diu-Melusin
Diu-melusin
Diuril
Diurogen
DivK1c_000289
Dixidrasi
Drenol
Dyazide
EINECS 200-403-3
EU-0100614
Esidrex
Esidrix
Esidrix (TN)
Esimil
Esoidrina
FT-0082750
Fluvin
H 4759
H1274
H2910_SIAL
H4759_SIAL
HCT
HCT-Isis
HCTZ
HCZ
HMS1568A19
HMS1920D19
HMS2091L05
HMS500O11
HMS553N04
HSDB 3096
Hidril
Hidro-Niagrin
Hidrochlortiazid
Hidroclorotiazida
Hidroclorotiazida [INN-Spanish]
Hidroronol
Hidrosaluretil
Hidrotiazida
Hyclosid
Hydrex-semi
Hydril
Hydro Par
Hydro-Aquil
Hydro-D
Hydro-Diuril
Hydro-Saluric
Hydro-T
Hydro-chlor
HydroDIURIL
Hydrochlorat
Hydrochloro Thiazide
Hydrochlorot
Hydrochlorothiazid
Hydrochlorothiazide
Hydrochlorothiazide (JP15/USP/INN)
Hydrochlorothiazide Intensol
Hydrochlorothiazide [INN:BAN:JAN]
 
Hydrochlorothiazidum
Hydrochlorothiazidum [INN-Latin]
Hydrochlorthiazide
Hydrochlorthiazidum
Hydrocot
Hydrodiuretic
Hydrodiuril
Hydropres
Hydrosaluric
Hydrothide
Hydrozide
Hydrozide Injection, Veterinary
Hypothiazid
Hypothiazide
Hytrid
Hyzaar
I09-0531
IDI1_000289
Idroclorotiazide
Idroclorotiazide [DCIT]
Idrotiazide
Inderide
Inderide 80/25
Indroclor
Ivaugan
Jen-Diril
KBio1_000289
KBio2_001357
KBio2_003925
KBio2_006493
KBio3_001352
KBioGR_000351
KBioSS_001357
LS-243
Lopac-H-4759
Lopac0_000614
Lopressor HCT
Lotensin HCT
Lotensin Hct
MLS000069619
Manuril
Maschitt
Maxzide
Maybridge Compound 10
Maybridge1_004336
Mazide 25 mg
Medozide
Megadiuril
Microzide
Microzide (TN)
Mictrin
Mikorten
Modurcen
Moduretic
MolPort-000-144-465
NCGC00015508-01
NCGC00015508-02
NCGC00015508-03
NCGC00015508-07
NCGC00015508-12
NCGC00021906-03
NCGC00021906-04
NCGC00021906-05
NCGC00021906-06
NCGC00021906-07
NCGC00021906-08
NCI-C55925
NCI60_004317
NINDS_000289
NSC 53477
NSC53477
Natrinax
Nefrix
Nefrol
Neo-Codema
Neo-Flumen
Neo-Minzil
Neo-codema
Neoflumen
Newtolide
Novodiurex
Oprea1_357174
Oretic
Pantemon
Panurin
Prestwick0_000009
Prestwick1_000009
Prestwick2_000009
Prestwick3_000009
Prestwick_263
Prinzide
Raunova Plus
Ro-Hydrazide
Ro-hydrazide
Roxane
S1708_Selleck
SAM002554901
SMR000035778
SPBio_001259
SPBio_001938
SPECTRUM1500335
STK315354
Saldiuril
Sectrazide
Selozide
Ser-Ap-Es
Servithiazid
Spectrum2_001040
Spectrum3_000456
Spectrum4_000006
Spectrum5_000824
Spectrum_000877
Spironazide
Su 5879
Tandiur
Thiaretic
Thiuretic
Thlaretic
Timolide
UNII-0J48LPH2TH
Unazid
Unipres
Urodiazin
Urozide
Vaseretic
Vetidrex
WLN: T66 BSWM EM DHJ HG ISZW
ZINC00896569
Ziac
Zide
adiazine-1,1-dioxide
component of Aldactazide
component of Aldoril
component of Caplaril
component of Cyclex
component of Dyazide
component of Esimil
diclot ride
dro-2H-1,2,4-benzothiadiazine 1,1-dioxide
hydrochlorothiazide
panurin dichloride
3
DenosumabapprovedPhase 3138615258-40-7
Synonyms:
615258-40-7
AMG-162
D03684
Denosumab
 
Denosumab (USAN)
Denosumab (genetical recombination)
Denosumab (genetical recombination) (JAN)
Prolia
Xgeva
4EndorphinsPhase 2, Phase 370
5Bone Density Conservation AgentsPhase 2, Phase 33376
6Hormone AntagonistsPhase 2, Phase 313180
7Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 2, Phase 313168
8Neurotransmitter AgentsPhase 2, Phase 318340
9Melanocyte-Stimulating HormonesPhase 2, Phase 3139
10beta-endorphinPhase 2, Phase 3140
11HormonesPhase 2, Phase 314415
12Adrenocorticotropic HormonePhase 2, Phase 3164
13AnticoagulantsPhase 32623
14Chelating AgentsPhase 31423
15Calcium, DietaryPhase 3, Phase 2, Phase 15713
16ExpectorantsPhase 3404
17diureticsPhase 3, Phase 21418
18Respiratory System AgentsPhase 34997
19Pharmaceutical SolutionsPhase 38192
20Natriuretic AgentsPhase 3, Phase 21697
21VitaminsPhase 3, Phase 25282
22Antihypertensive AgentsPhase 2, Phase 34207
23vitamin dPhase 31724
24Sodium Chloride Symporter InhibitorsPhase 2, Phase 3452
25Calcimimetic AgentsPhase 371
26Cinacalcet HydrochloridePhase 371
27CitrateNutraceuticalPhase 31160
28
Citric Acidnutraceutical, vet_approvedPhase 3116077-92-9311
Synonyms:
2-Hydroxy-1,2,3-propanetricarboxylate
2-Hydroxy-1,2,3-propanetricarboxylic acid
2-Hydroxytricarballylic acid
3-Carboxy-3-hydroxypentane-1,5-dioate
3-Carboxy-3-hydroxypentane-1,5-dioic acid
Aciletten
Anhydrous citrate
Anhydrous citric acid
Chemfill
Citraclean
 
Citrate
Citretten
Citric acid
Citro
Citronensäure
E 330
Hydrocerol A
Kyselina citronova
Suby G
Uro-trainer
beta-Hydroxytricarballylate
beta-Hydroxytricarballylic acid
29
Teriparatideapproved, investigationalPhase 213752232-67-416133850
Synonyms:
52232-67-4
D06078
Forteo
Forteo (TN)
 
TERIPARATIDE
Teriparatide (USAN/INN)
Teriparatide (genetical recombination)
Teriparatide (genetical recombination) (JAN)
Teriparatide recombinant human
30
AmilorideapprovedPhase 2532016-88-8, 2609-46-316231
Synonyms:
17440-83-4 (hydrochloride)
1f5l
2016-88-8 (anhydrous hydrochloride)
2609-46-3
3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide
3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
3,5-diamino-6-chloro-N-(diaminomethylidene)pyrazine-2-carboxamide
3,5-diamino-N-[amino(imino)methyl]-6-chloropyrazine-2-carboxamide
3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide
AB00053415
AC-13631
AC1L27IZ
AC1Q3POC
AMILORIDE
AMILORIDE (SEE ALSO: AMILORIDE HCL (2016-88-8))
Amiclaran
Amiclaran (TN)
Amikal (Hydrochloride dihydrate)
Amilorid
Amilorida
Amilorida [INN-Spanish]
Amiloride (INN)
Amiloride HCL
Amiloride [INN:BAN]
Amiloride hydrochloride hydrate
Amiloridum
Amiloridum [INN-Latin]
Amipramidin
Amipramidine
Amipramizid
Amipramizide
Amiprazidine
Amyloride
BCBcMAP01_000101
BIDD:GT0466
BPBio1_000015
BRD-K97181089-003-02-3
BRD-K97181089-310-03-0
BSPBio_000013
BSPBio_001572
BSPBio_001826
Bio1_000359
Bio1_000848
Bio1_001337
Bio2_000292
Bio2_000772
C06821
C6H8ClN7O
CCRIS 6545
CHEBI:2639
CHEMBL945
CID16231
CPD-10324
D07447
DB00594
DivK1c_000182
EINECS 220-024-7
Guanamprazin
 
Guanamprazine
HMS1791O14
HMS1989O14
HMS2089H05
IDI1_000182
IDI1_034042
KBio1_000182
KBio2_000292
KBio2_000394
KBio2_002860
KBio2_002962
KBio2_005428
KBio2_005530
KBio3_000583
KBio3_000584
KBio3_001326
KBioGR_000292
KBioGR_000544
KBioSS_000292
KBioSS_000394
LS-1094
Lopac-A-7410
Lopac0_000111
MK-870 (Hydrochloride dihydrate)
MLS000758249
MLS001060798
Midamor
Midamor (Hydrochloride dihydrate)
MolPort-005-934-472
MolPort-005-937-651
N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide
N-Amidino-3,5-diamino-6-chlorpyrazincarboxamid
N-amidino-3,5-diamino-6-chloropyrazinecarboxamide
NCGC00015089-01
NCGC00015089-02
NCGC00015089-12
NCGC00024443-02
NCGC00024443-05
NCGC00024443-06
NCGC00024443-07
NCGC00024443-09
NINDS_000182
Prestwick0_000007
Prestwick1_000007
Prestwick2_000007
Prestwick3_000007
Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride
SMR000449325
SMR000486264
SPBio_000136
SPBio_001934
ST079279
Spectrum2_000118
Spectrum3_000293
Spectrum4_000132
Spectrum5_000776
Spectrum_000034
Tocris-0890
UNII-7DZO8EB0Z3
ZINC04340269
31
Alfacalcidolapproved, nutraceuticalPhase 26141294-56-85282181
Synonyms:
(5Z,7e)-9,10-Seco-5,7,10(19)-cholestatrien-1alpha,3beta-diol
1-Hydroxycholecalciferol
1-hydroxycholecalciferol
1alpha-Hydroxy-vitamin D3
 
1alpha-hydroxycholecalciferol
1alpha-hydroxyvitamin D3
9,10-Secocholesta-5,7,10(19)-triene-1alpha,3beta-diol
Alfacalcidolum
Alsiodol
32Sodium Channel BlockersPhase 21593
33Trace ElementsPhase 26001
34MicronutrientsPhase 26001
35Diuretics, Potassium SparingPhase 21917
36HydroxycholecalciferolsPhase 2129
37potassium phosphatePhase 1, Phase 211
38Phosphorus SupplementNutraceuticalPhase 1, Phase 24
39
Magnesium Sulfateapproved, vet_approved1797487-88-924083
Synonyms:
(C10-C16) Alkylalcohol sulfuric acid, magnesium salt
00627_FLUKA
10028-26-9
10034-99-8 (heptahydrate)
13143_RIEDEL
13143_SIAL
139939-75-6
18939-43-0
203726_ALDRICH
208094_SIAL
34276_FLUKA
34276_RIEDEL
38146_FLUKA
38146_RIEDEL
63126_FLUKA
63136_FLUKA
63136_SIAL
63139_FLUKA
63139_SIAL
68081-97-0
7487-88-9
AC1L2N76
AC1LAX36
AC1Q1U66
AI3-02029
Bitter salt
C10-C16 Alkyl alcohol sulfuric acid magnesium salt
CCRIS 8411
CHEBI:32599
CID24083
CPD0-2390
Caswell No. 534
D008278
DB00653
EINECS 231-298-2
EINECS 233-073-4
EINECS 242-691-3
EINECS 268-365-0
EPA Pesticide Chemical Code 050503
Epsom salt
HSDB 664
Hair salt
Heptahydrate Magnesium Sulfate
Kieserite [as monohydrate]
LS-88605
M2643_SIGMA
M3409_SIGMA
 
M7506_SIAL
M8150_SIGMA
MAGNESIUM SULFATE
Magnesium Sulfate In Plastic Container
Magnesium Sulfate, Heptahydrate
Magnesium Sulphate Hydrate
Magnesium bisulfate
Magnesium hydrogensulphate
Magnesium sulfate
Magnesium sulfate (1:1)
Magnesium sulfate anhydrous
Magnesium sulfate dried
Magnesium sulfate heptahydrate
Magnesium sulfate hexahydrate
Magnesium sulfate in dextrose 5% in plastic container
Magnesium sulfate solution
Magnesium sulphate
Magnesium sulphate anhydrous
Magnesium sulphate dried
Magnesium sulphate heptahydrate
Magnesium(II) sulfate
Magnesium(ii) sulfate
Magnesiumsulfat
MgSO4
MolPort-003-925-000
NSC 146179
OT-S
OT-S (drying agent)
SDA 15-062-07
Sal Angalis
Sal De sedlitz
Sal amarum
Sal anglicum
Sal catharticum
Sal seidlitense
Salts of england
Sel d'angleterre
Sulfate, Magnesium
Sulfuric acid magnesium salt
Sulfuric acid magnesium salt (1:1)
Sulfuric acid magnesium salt (VAN)
Sulfuric acid, C10-16 alkyl ester, magnesium salt
Sulfuric acid, magnesium salt
Sulfuric acid, magnesium salt (1:1)
Sulfuric acid, mono-C10-16-alkyl esters, magnesium salts
Tomix OT
UNII-DE08037SAB
UNII-ML30MJ2U7I
magnesium(2+) ion sulfate
40
Caffeineapproved, Nutraceutical39658-08-22519
Synonyms:
07E4FB58-FD79-4175-8E3D-05BF96954522
1,3,7-Trimethyl-2,6-dioxopurine
1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione
1,3,7-Trimethylpurine-2,6-dione
1,3,7-Trimethylxanthine
1,3,7-trimethyl-2,6-dioxopurine
1,3,7-trimethylpurine-2,6-dione
1,3,7-trimethylxanthine
1-3-7-TRIMETHYLXANTHINE
1-Methyl-Theobromine
1-methyltheobromine
137X
1gfz
1l5q
1l7x
27602_FLUKA
2a3b
3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion
3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
3,7-dihydro-1,3,7-trimethyl-1H-purine
5-26-13-00558 (Beilstein)
58-08-2
7-Methyl Theophylline
7-Methyltheophylline
7-methyltheophylline
71701-02-5
75035_FLUKA
95789-13-2
A.S.A. and Codeine Compound
AC-12774
AC1L1DV2
AC1Q3Z23
ACon1_000085
AI3-20154
AKOS000121334
Alert-Pep
Alert-pep
Anacin Maximum Strength
Anhydrous caffeine
Anhydrous caffeine (JP15)
Anhydrous caffeine (TN)
Anoquan
BIDD:ER0554
BIDD:GT0632
BIDD:PXR0172
BIM-0050216.0001
BRD-K02404261-001-02-7
BRD-K02404261-001-03-5
BRN 0017705
BSPBio_001921
Berlin-Chemie Brand of Caffeine
Bio-0579
Bio1_000473
Bio1_000962
Bio1_001451
Bristol-Myers Squibb Brand of Caffeine
C 0750
C07481
C0750_SIAL
C1778_SIAL
C2042
C6035_FLUKA
C6035_SIGMA
C7731_SIAL
C8960_SIAL
CCRIS 1314
CFF
CHEBI:27732
CHEMBL113
CID2519
CU-01000012617-3
Cafamil
Cafcit
Cafecon
Cafeina
Cafergot
Cafeína
Caffedrine
Caffedrine Caplets
Caffein
Caffeina
Caffeina [Italian]
Caffeine (USP)
Caffeine (natural)
Caffeine Pure
Caffeine [BAN:JAN]
Caffeine solution
Caffeine, Anhydrous
Caffeine, Monohydrate
Caffeine, Synthetic
Caffeine, anhydrous
Caffeine, synthetic
Caffeinum
Caffine
Cafipel
Caféine
Coffein
Coffein [German]
Coffeine
Coffeinum
Coffeinum N
Coffeinum Purrum
Compound 65
D002110
D00528
DB00201
DHC Plus
DHCplus
Darvon Compound
Darvon Compound-65
Dasin
Dexitac
Dexitac Stay Alert Stimulant
Dhc Plus
Diurex
DivK1c_000730
Durvitan
EINECS 200-362-1
EU-0100228
Eldiatric C
Enerjets
Ercatab
Esgic
Esgic-Plus
FEMA No. 2224
Femcet
Fioricet
Fiorinal
GlaxoSmithKline Brand of Caffeine
Guaranine
HMS1920I09
HMS2091O11
HMS502E12
HSDB 36
Hycomine
Hycomine Compound
I14-4386
 
IDI1_000730
Invagesic
Invagesic Forte
KBio1_000730
KBio2_001781
KBio2_004349
KBio2_006917
KBio3_001141
KBioGR_002325
KBioSS_001781
Keep Alert
Kofein
Kofein [Czech]
Koffein
Koffein [German]
L000155
LS-237
Lanorinal
Lopac-C-0750
Lopac0_000228
MEGxp0_001350
MLS001055341
MLS001056714
MLS001066409
Mateina
Mateína
Maximum Strength Snapback Stimulant Powders
Medigesic Plus
Merck dura Brand of Caffeine
Methyltheobromide
Methyltheobromine
Methylxanthine theophylline
Midol Maximum Strength
Migergot
Miudol
MolMap_000054
MolPort-000-730-850
Monohydrate Caffeine
Monomethyl Derivative of Theophylline
Monomethyl derivative of Theophylline
NCGC00015208-01
NCGC00015208-02
NCGC00015208-04
NCGC00015208-14
NCGC00090699-01
NCGC00090699-02
NCGC00090699-03
NCGC00090699-04
NCGC00090699-05
NCGC00090699-06
NCGC00090699-07
NCGC00090699-08
NCGC00090699-09
NCGC00168808-01
NCGC00168808-02
NCI-C02733
NCIOpen2_008255
NINDS_000730
NSC 5036
NSC5036
Natural Caffeinum
Nix Nap
No Doz
No-Doz
Nodaca
Nodoz Maximum Strength Caplets
Norgesic
Norgesic Forte
Organex
Orphengesic
Orphengesic Forte
P-A-C Analgesic Tablets
PDSP1_001016
PDSP1_001235
PDSP2_001000
PDSP2_001219
Passauer Brand of Caffeine
Pep-Back
Percoffedrinol N
Percutafeine
Phensal
Pierre Fabre Brand of Caffeine
Probes1_000150
Probes2_000128
Propoxyphene
Propoxyphene Compound 65
Propoxyphene Compound-65
Quick Pep
Quick-Pep
Refresh'n
Republic Drug Brand of Caffeine
SDCCGMLS-0064595.P001
SDCCGMLS-0064595.P002
SK 65 Compound
SK-65 Compound
SMR000326667
SPBio_001222
SPECTRUM1500155
STK177283
Seid Brand of Caffeine
Spectrum2_001261
Spectrum3_000321
Spectrum4_001782
Spectrum5_000423
Spectrum_001301
Stim
Synalgos-Dc
TNP00310
Thein
Theine
Theobromine ME
Theobromine Me
Theophylline ME
Theophylline Me
Theophylline, 7-methyl
Thompson Brand 1 of Caffeine
Thompson Brand 2 of Caffeine
Tirend
Tri-Aqua
Triad
UNII-3G6A5W338E
Ultra Pep-Back
Vivarin
W222402_ALDRICH
WLN: T56 BN DN FNVNVJ B1 F1 H1
Wake-Up
Wigraine
Xanthine, 1,3,7-trimethyl
ZINC00001084
bmse000206
cafeine
caffeine
caffenium
component of Cafergot
nchembio.243-comp7
nchembio.63-comp5
nchembio774-comp2
teina
teína
41
Ergocalciferolapproved, nutraceutical128150-14-65280793
Synonyms:
'Ergosterol irradiated'
(+)-Vitamin D2
(3-beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10,(19),22-tetraen-3-ol
(3S,5Z,7E,14xi,17alpha,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3S,5Z,7E,22E)-9,10-secoergosta-5,7,10,22-tetraen-3-ol
(3beta,5Z,7E,22E)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(3beta,5Z,7e,22e)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
(5E,7E,22E)-9,10-Secoergosta-5,7,10,22-tetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7E,22E)-(3S)-9,10-secoergosta-5,7,10(19),22-tetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Seco-5,7,10(19),22-ergostatetraen-3-ol
(5Z,7e,22e)-(3S)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol
22-Tetraen 3beta 9,10,Secoergosta-5,7,10(19)-ol
31316-19-5
4-Methylene-3-[2-[tetrahydro-7a-methyl-1-(1,4,5-trimethyl-2-hexenyl)-4(3aH)-indanylidene]ethylidene]-Cyclohexanol
47768_SUPELCO
50-14-6
7489-18-1
7E677DC1-E1C4-4FC5-8F4A-BCE1857F7E87
8017-28-5
9,10,Secoergosta-5,7,10(19),22-tetraen 3.beta.-ol
9,10-Seco(5Z,7E,22E)-5,7,10(19),22-ergostatetraen-3-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3-beta-ol
9,10-Secoergosta-5,7,10(19),22-tetraen-3b-ol
95220_FLUKA
95220_SIGMA
AC-1355
AC1L1FIE
AC1NQXLH
AC1NS4DE
AC1NS9GI
AC1NSSVD
AC1NWAM3
AC1O5EDK
AC1O6WAM
ACon1_002187
Activated ergosterol
BPBio1_000418
BSPBio_000380
BSPBio_001974
Buco-D
C05441
C28H44O
CALCIFEROL IN A GELATIN MATRIX
CALCIFEROL, U.S.P.
CHEBI:28934
CHEMBL1536
CID11003810
CID3249
CID5280793
CID5315257
CID5353610
CID5356615
CID5702050
CID6432478
CID6536972
Calciferol
Calciferol (TN)
Calciferol (vitamin D2)
Calciferolum
Calciferon 2
Condacaps
Condocaps
Condol
Crtron
Crystallina
D-Arthin
D-Tracetten
D00187
DB00153
Daral
Davitamon D
Davitin
De-rat concentrate
Decaps
Dee-Osterol
Dee-Ron
Dee-Ronal
Dee-Roual
Deltalin
Deratol
Detalup
Diactol
Divit urto
Doral
Drisdol
Drisdol (TN)
E5750_SIGMA
EINECS 200-014-9
Ercalciol
Ergocalciferol
Ergocalciferol (D2)
Ergocalciferol (JP15/USP)
Ergocalciferol [INN:BAN:JAN]
Ergocalciferol oil
Ergocalciferol: Vitamin D
 
Ergocalciferolo
Ergocalciferolo [DCIT]
Ergocalciferols
Ergocalciferolum
Ergocalciferolum [INN-Latin]
Ergorone
Ergosterol activated
Ergosterol irradiated
Ergosterol, irradiated
Ertron
Fortodyl
Geltabs
Geltabs Vitamin D
HMS1920K20
HMS2091B19
HMS502I07
HSDB 819
Haliver
Hi-Deratol
Hyperkil
I05-0022
IDI1_000805
Infron
Irradiated ergosta-5,7,22-trien-3-beta-ol
Irradiated ergosta-5,7,22-trien-3.beta.-ol
Irradiated ergosta-5,7,22-trien-3beta-ol
Irradiated ergosterol
LMST03010001
LMST03010014
LS-3228
MEGxm0_000466
MLS001332467
MLS001332468
Metadee
Mina D2
MolPort-001-740-057
MolPort-001-793-930
MolPort-002-526-645
MolPort-003-666-178
MolPort-006-822-629
Mulsiferol
Mykostin
NCGC00142497-01
NCGC00179579-01
NCGC00179579-02
NSC 62792
NSC62792
Novovitamin-D
Oleovitamin D
Oleovitamin D, Synthetic
Oleovitamin D2
Osteil
Ostelin
Prestwick3_000420
Prestwick_554
Radiostol
Radstein
Radsterin
Rodine C
Rodinec
SMR000857106
SPECTRUM1500276
ST057150
STOCK1N-53397
Shock-ferol
Shock-ferol sterogyl
Sorex C.R
Sorex C.R.
Spectrum5_000666
Sterogyl
Synthetic Vitamin D
UNII-VS041H42XC
Uvesterol D
Uvesterol-D
VITAMIN D2
VITAMIN D2 WATER DISPERSABLE U.S.P.
VITAMIN_D2
Vigantol
Vio D
Vio-D
Viostdrol
Viosterol
Viosterol in Oil
Vitamin D2
Vitamin- D2
Vitamin-?D2
Vitamina D2
Vitavel-D
WLN: L56 FYTJ A1 BY1&1U1Y1&Y1&1 FU2U- BL6YYTJ AU1 DQ
ZINC04474571
ZINC04629876
beta-Ol
bmse000510
component of Geltabs Vitamin D
delta-Arthin
delta-Tracetten
ergocalciferol
vitamin d-2
42Central Nervous System Stimulants2211
43Phosphodiesterase Inhibitors1289
44Purinergic P1 Receptor Antagonists360
45Ergocalciferols1281
46Central Nervous System Depressants13403
47Tocolytic Agents739
48calcium channel blockers1985
49Peripheral Nervous System Agents23689
50Anti-Arrhythmia Agents3093

Interventional clinical trials:

(show all 16)
idNameStatusNCT IDPhase
1Study to Assess the Efficacy and Safety of Oral Potassium Citrate on the Prevention of Nephrocalcinosis in Extreme PrematureUnknown statusNCT01756547Phase 3
2ACTHAR GEL for Sarcoidosis-Associated Calcium Dysregulation: An Open-label Pilot StudyUnknown statusNCT02155803Phase 2, Phase 3
3Alkaline Citrate Treatment to Lower the Risk of Nephrocalcinosis in Preterm InfantsCompletedNCT00249951Phase 3
4Effects of PTH Replacement on Bone in HypoparathyroidismActive, not recruitingNCT00395538Phase 3
5Treatment of Primary Hyperparathyroidism With Denosumab and Cinacalcet.Not yet recruitingNCT03027557Phase 3
6Dose-Dependent Effect of Thiazide in Dent's Disease HypercalciuriaTerminatedNCT00638482Phase 2, Phase 3
7Role Of Phosphorus And FGF 23 In Patients With Dent DiseaseRecruitingNCT02016235Phase 1, Phase 2
8Recombinant Human rhPTH(1-34) VS Association Alfacalcidol/Hydrochlorothiazide in Autosomal Dominant HypocalcemiaRecruitingNCT02824718Phase 2
9Renal Tubular Acidosis in Incident Renal Transplant RecipientsUnknown statusNCT01283880
10Preterm Infants and NephrocalcinosisCompletedNCT02438267
11Effect of Caffeine on Preterm Infants' Bone Mineral ContentCompletedNCT03084432
12Search for New Genetic Causes of Hypercalcemia by Massively Parallel Sequencing of a Genes PanelRecruitingNCT02908542
13Randall's Plaque Study: Pathogenesis and Relationship to NephrolithiasisRecruitingNCT00169806
14Monitored vs Standard Supplementation of Vitamin D in Preterm InfantsRecruitingNCT03087149
15Effect of Magnesium Sulfate Infusion Rate on Magnesium Retention in Critically Ill PatientsTerminatedNCT01426165
16International Registry for Primary HyperoxaluriaWithdrawnNCT00875823

Search NIH Clinical Center for Nephrocalcinosis


Cochrane evidence based reviews: nephrocalcinosis

Genetic Tests for Nephrocalcinosis

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Genetic tests related to Nephrocalcinosis:

id Genetic test Affiliating Genes
1 Nephrocalcinosis27

Anatomical Context for Nephrocalcinosis

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MalaCards organs/tissues related to Nephrocalcinosis:

36
Kidney, Bone, Thyroid, Liver, Heart, T cells, Testes

Publications for Nephrocalcinosis

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Articles related to Nephrocalcinosis:

(show top 50)    (show all 565)
idTitleAuthorsYear
1
Focal segmental glomerulosclerosis and medullary nephrocalcinosis in children with ADCK4 mutations. (28405841)
2017
2
Medullary Nephrocalcinosis in a Furosemide Abuser. (28090060)
2017
3
Claudin 19-based familial hypomagnesemia with hypercalciuria and nephrocalcinosis in a sibling pair. (27007868)
2016
4
Rare case of nephrocalcinosis in a 14-year-old girl: Questions. (27384690)
2016
5
Prevalence of Monogenic Causes in Pediatric Patients with Nephrolithiasis or Nephrocalcinosis. (26787776)
2016
6
Genetic, Pathophysiological and Clinical Aspects of Nephrocalcinosis. (27605580)
2016
7
Osteopontin protects against high phosphate-induced nephrocalcinosis andA vascularA calcification. (27083280)
2016
8
A novel mutation in CLDN16 results in rare familial hypomagnesaemia with hypercalciuria and nephrocalcinosis in a Chinese family. (27067446)
2016
9
A rare case of nephrocalcinosis in the distal tubules caused by hereditary renal hypouricemia three months after kidney transplantation. (26971588)
2016
10
Bilateral Nephrocalcinosis in Primary Distal Renal Tubular Acidosis. (27090423)
2016
11
Amelogenesis imperfecta in familial hypomagnesaemia and hypercalciuria with nephrocalcinosis caused by CLDN19 gene mutations. (27530400)
2016
12
Hashimoto Thyroiditis and Nephrocalcinosis in a Child with Down Syndrome. (27147809)
2016
13
Rare case of nephrocalcinosis in a 14-year-old girl: Answers. (27384692)
2016
14
Pseudoxanthoma elasticum and nephrocalcinosis. (27181788)
2016
15
Nephrocalcinosis in Tunisian children. (27704510)
2016
16
Loss of function of NaPiIIa causes nephrocalcinosis and possibly kidney insufficiency. (27378183)
2016
17
Nephrocalcinosis and Renal Failure in Lesch-Nyhan Syndrome: Report of Two Familial Cases and Review of the Literature. (27079129)
2016
18
Lakes of Extramedullary Hematopoiesis in a Renal Hemangioma With Extensive Nephrocalcinosis. (27571793)
2016
19
Recent advances in managing and understanding nephrolithiasis/nephrocalcinosis. (27134735)
2016
20
Failure to thrive and nephrocalcinosis due to distal renal tubular acidosis: A rare presentation of pediatric lupus nephritis. (27900972)
2016
21
Hypercalcemia and nephrocalcinosis complicating subcutaneous fat necrosis in a newborn after therapeutic hypothermia. (27277205)
2016
22
Re: Prevalence of Monogenic Causes in Pediatric Patients with Nephrolithiasis or Nephrocalcinosis. (27479436)
2016
23
Bilateral nephrocalcinosis in primary hyperoxaluria type 1. (27795638)
2016
24
Nephrocalcinosis and retinal dystrophy, rare manifestations of MPV17-related mitochondrial depletion syndrome? (27668186)
2016
25
Nephrocalcinosis in Calcium Stone Formers Who Do Not have Systemic Disease. (25988516)
2015
26
Re: Loss-of-Function Mutations of CYP24A1, the Vitamin D 24-hydroxylase Gene, Cause Long-standing Hypercalciuric Nephrolithiasis and Nephrocalcinosis. (26088734)
2015
27
Primary Hyperoxaluria Type 1: A Cause for Infantile Renal Failure and Massive Nephrocalcinosis. (26090995)
2015
28
Posttransplant nephrocalcinosis is associated with poor renal allograft function: a single-center experience. (25829877)
2015
29
Chondrocalcinosis related to familial hypomagnesemia with hypercalciuria and nephrocalcinosis. (25720051)
2015
30
Re: Fourteen monogenic genes account for 15% of nephrolithiasis/nephrocalcinosis. (25986801)
2015
31
Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis: clinical and molecular characteristics. (26613020)
2015
32
Nephrolithiasis and Nephrocalcinosis in Children - Metabolic and Genetic Factors. (26540764)
2015
33
Medullary nephrocalcinosis in Schimke immuno-osseous dysplasia. (25868949)
2015
34
Risk factors affecting the development of nephrocalcinosis, the most common complication of hypophosphatemic rickets. (26203600)
2015
35
Lots of steroids and vitamins, tons of complications. Hypercalcemia and nephrocalcinosis as important complications of performance-enhancing drugs. (26474528)
2015
36
An Association of Chronic Hyperaldosteronism with Medullary Nephrocalcinosis. (26413177)
2015
37
Revisiting nephrocalcinosis: A single-center perspective. (26058976)
2015
38
A Spectrum: Nephrocalcinosis-Nephrolithiasis. (26279238)
2015
39
Microscopic nephrocalcinosis in chronic kidney disease patients. (25586405)
2015
40
First Report of a Novel Missense CLDN19 Mutations Causing Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis in a Chinese Family. (25555744)
2015
41
Re: Nephrocalcinosis is a Risk Factor for Kidney Failure in Primary Hyperoxaluria. (25765399)
2015
42
Bi-allelic CLPB mutations cause cataract, renal cysts, nephrocalcinosis and 3-methylglutaconic aciduria, a novel disorder of mitochondrial protein disaggregation. (25595726)
2015
43
What is nephrocalcinosis? (25807034)
2015
44
Discordant Clinical Course of Vitamin-D-Hydroxylase (CYP24A1) Associated Hypercalcemia in Two Adult Brothers With Nephrocalcinosis. (26304832)
2015
45
Bilateral nephrocalcinosis and amelogenesis imperfecta: A case report. (26097369)
2015
46
Renal Cysts and Nephrocalcinosis in a Patient Deficient in 11 beta-Hydroxylase Enzyme. (26309449)
2015
47
Retrospective cohort study of familial hypomagnesaemia with hypercalciuria and nephrocalcinosis due to CLDN16 mutations. (25477417)
2015
48
Haplotype analysis of CLDN19 single nucleotide polymorphisms in Spanish patients with familial hypomagnesemia with hypercalciuria and nephrocalcinosis. (25410674)
2014
49
Exome Sequencing Identifies a Novel Homozygous Mutation in the Phosphate Transporter SLC34A1 in Hypophosphatemia and Nephrocalcinosis. (25050900)
2014
50
Familial hypomagnesemia with hypercalciuria and nephrocalcinosis: variable phenotypic expression in three affected sisters from Mexican ancestry. (25366522)
2014

Variations for Nephrocalcinosis

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Expression for genes affiliated with Nephrocalcinosis

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Search GEO for disease gene expression data for Nephrocalcinosis.

Pathways for genes affiliated with Nephrocalcinosis

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Pathways related to Nephrocalcinosis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6AGXT, GRHPR
2
Show member pathways
9.6AGXT, GRHPR
39.6AGXT, GRHPR
49.1CLCNKB, KCNJ1, SLC12A1
5
Show member pathways
9.0ATP6V1B1, CLCNKB, SLC4A1
6
Show member pathways
7.8ATP6V1B1, CLCN5, CLCNKB, SLC12A1, SLC34A1, SLC4A1

GO Terms for genes affiliated with Nephrocalcinosis

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Cellular components related to Nephrocalcinosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peroxisomal matrixGO:000578210.4AGXT, GRHPR
2basolateral plasma membraneGO:00163239.8ATP6V1B1, CLDN19, SLC4A1
3apical plasma membraneGO:00163249.6ATP6V1B1, SLC12A1, SLC34A1
4plasma membraneGO:00058866.9CLCN5, CLCNKB, CLDN16, CLDN19, CYP24A1, KCNJ1

Biological processes related to Nephrocalcinosis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1calcium-independent cell-cell adhesion via plasma membrane cell-adhesion moleculesGO:001633810.7CLDN16, CLDN19
2regulation of anion transmembrane transportGO:190395910.6CLCN5, CLCNKB
3cellular nitrogen compound metabolic processGO:003464110.4AGXT, GRHPR
4glyoxylate metabolic processGO:004648710.4AGXT, GRHPR
5chloride transmembrane transportGO:19024769.9CLCN5, CLCNKB, SLC12A1, SLC4A1
6chloride transportGO:00068219.9CLCN5, CLCNKB, SLC12A1, SLC4A1
7ion transmembrane transportGO:00342209.3ATP6V1B1, CLCN5, CLCNKB, SLC12A1
8excretionGO:00075888.3ATP6V1B1, CLCN5, CLCNKB, CLDN16, GRHPR, KCNJ1
9ion transportGO:00068117.7ATP6V1B1, CLCN5, CLCNKB, CLDN16, KCNJ1, SLC12A1
10transportGO:00068106.9ATP6V1B1, CLCN5, CLCNKB, CLDN16, KCNJ1, SLC12A1

Molecular functions related to Nephrocalcinosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1voltage-gated chloride channel activityGO:00052479.8CLCN5, CLCNKB

Sources for Nephrocalcinosis

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet