Nephrocalcinosis malady

NIH Rare Diseases: Nephrocalcinosis is a disorder in which there is excess calcium deposited in the kidneys. It is relatively common in premature infants. Individuals may be asymptomatic or have symptoms related to the condition causing nephrocalcinosis. If kidney stones are present, an individual may have blood in the urine; fever and chills; nausea and vomiting; or severe pain in the belly area, sides of the back (flank), groin, or testicles. Later symptoms related to nephrocalcinosis may be associated with chronic kidney failure. It may be caused by use of certain medications or supplements; infection; or any condition that leads to high levels of calcium in the blood or urine including hyperparathyroidism, renal tubular acidosis, Alport syndrome, Bartter syndrome, and a variety of other conditions. Some of the underlying disorders that can cause nephrocalcinosis are genetic, with the inheritance pattern depending on the specific disorder. The goal of treatment is to reduce symptoms and prevent more calcium from being deposited in the kidneys.³⁰

MalaCards: Nephrocalcinosis, also known as nephrocalcinosis (disorder), is related to hypomagnesemia and hypercalciuria. An important gene associated with Nephrocalcinosis is CLDN16 (claudin 16), and among its related pathways are Selected targets of HNF1 and Hepatic ABC Transporters. The compounds calcium oxalate and Methyclothiazide have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are behavior/neurological and digestive/alimentary.

Wikipedia: Nephrocalcinosis, once known as Albright\'s calcinosis after Fuller Albright, is a term originally used...⁴⁴ more...

Aliases & Descriptions:

nephrocalcinosis 6 30 8 32 43 nephrocalcinosis (disorder) 6

hypercalcemic nephropathy 30

Diseases related to nephrocalcinosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 114)

id	Related Disease	Score	Top Affiliating Genes
1	hypomagnesemia	30.0	CLCNKB, CLDN16, CLDN19, FXYD2, SLC12A3, SLC12A1
2	hypercalciuria	29.6	CYP24A1, CASR, ALB, ATP6V1B1, KCNJ1, CLDN19
3	renal tubular acidosis	29.1	SLC4A1, OCRL, CA2, ATP6V1B1
4	proteinuria	28.3	OCRL, SPP1, HSD11B2, ALB, UMOD, CLCN5
5	sensorineural hearing loss	27.9	KCNJ1, ATP6V1B1, CASR, SLC12A1
6	dent disease	27.7	LRP2, SLC12A3, SLC12A1, OCRL, CLCN7, CLCN5
7	urolithiasis	27.6	SOX9, AGXT, SPP1, CA2, CASR, ALB
8	rickets	27.2	CYP24A1, CASR, ALB
9	fanconi syndrome	27.0	OCRL, ALB, CLCN5, NAGLU, LRP2
10	hypercalcemia	26.3	SI, SLC12A1, SLC34A1, NR1I3, CYP24A1, CASR
11	beta thalassemia	26.1	SLC4A1, HBB, HBA2, SPP1, ALB, NAGLU
12	thalassemia	26.0	SLC4A1, HBB, HBA2, SPP1, ALB, NAGLU
13	hearing loss	25.4	PHEX, ATP6V0A4, ATP6V1B1, XDH, CLCN1, LRP2
14	anemia	24.1	CA2, HBA2, HBB, SLC26A1, SLC4A1, ALB
15	primary hyperoxaluria	13.6	AGXT, GRHPR
16	hypophosphatemic rickets with hypercalciuria	13.6	SLC34A1, SLC34A3
17	hereditary hypophosphatemic rickets with hypercalciuria	13.6	SLC34A1, SLC34A3
18	bartter syndrome antenatal type 2	13.6	SLC12A1, KCNJ1
19	familial hypocalciuric hypercalcemia	13.5	NR1I3, CASR
20	hyperparathyroidism, neonatal severe primary	13.5	NR1I3, CASR
21	familial hypophosphatemia	13.4	SLC34A1, SLC34A3, PHEX, CLCN5
22	mucinous tubular and spindle renal cell carcinoma	13.4	NAGLU, CLCN5, SLC12A3
23	aminoaciduria	13.4	CLCN5, OCRL, SLC34A1
24	oculocerebrorenal syndrome	13.4	OCRL, NAGLU, LRP2
25	bartter syndrome type 3	13.3	SLC12A3, SLC12A1, KCNJ1, CLCNKB
26	polyhydramnios	13.3	SLC12A3, SLC12A1, KCNJ1, CLCNKB
27	renal tubular acidosis, distal	13.3	SLC4A1, ATP6V0A4, ATP6V1B1
28	renal tubular acidosis, distal, autosomal recessive	13.3	ATP6V1B1, ATP6V0A4, SLC4A1
29	lactic acidosis	13.3	NAGLU, CA2, OCRL, SLC4A1
30	pseudohypoaldosteronism	13.2	SLC12A3, SLC12A1, FXYD2, KCNJ1
31	x-linked hypophosphatemia	13.2	SLC34A1, SLC34A3, PHEX, CYP24A1, CLCN5
32	gitelman syndrome	13.2	SLC12A3, SLC12A1, CASR, KCNJ1, CLCNKB
33	secondary syphilis	13.2	PHEX, NR1I3, SPP1, CASR, CLCN7
34	medullary sponge kidney	13.2	SIK1, ATP6V0A4, ATP6V1B1
35	polycystic kidney disease, autosomal dominant	13.2	SLC4A1, SLC12A1, HBA2
36	chronic pyelonephritis	13.2	ALB, UMOD, NAGLU
37	calciphylaxis	13.1	SPP1, CASR, ALB
38	lipoid nephrosis	13.1	SPP1, ALB, NAGLU
39	glucose intolerance	13.1	SI, SLC12A1, SLC5A1
40	hyperaldosteronism	13.1	SLC12A3, SLC12A1, HSD11B2, KCNJ1, CLCNKB
41	secondary hyperparathyroidism of renal origin	13.1	ALB, CASR, NR1I3
42	hemoglobin constant spring	13.0	HBB, HBA2
43	hereditary spherocytosis	13.0	HBB, HBA2
44	autoimmune pancreatitis	12.9	SPP1, CA2, ALB
45	calcinosis	12.9	PHEX, SPP1, CASR
46	monogenic disease	12.9	AGXT, HBB, HBA2
47	primary hyperparathyroidism	12.9	NR1I3, CASR, ALB, LRP2
48	heinz body anemia	12.9	HBB, HBA2
49	hyperphosphatemia	12.9	SLC34A1, PHEX, SPP1, CASR, ALB
50	focal segmental glomerulosclerosis	12.9	SLC12A1, SPP1, ALB, CLCN5, NAGLU

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to nephrocalcinosis:

²²

MGI Mouse Phenotypes related to nephrocalcinosis:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	8.4	CASR, SPP1, PHEX, SOX9, SLC34A1, HSD11B2
2	digestive/alimentary phenotype	MP:0005381	8.0	SOX9, SLC5A1, SLC34A3, SLC26A1, PHEX, CA2
3	reproductive system phenotype	MP:0005389	7.8	OCRL, SOX9, SLC34A1, SLC12A1, HBB, NR1I3
4	integument phenotype	MP:0010771	7.6	HBB, SOX9, SLC12A1, SLC4A1, HBA2, CASR
5	skeleton phenotype	MP:0005390	7.2	SPP1, PHEX, HBB, SOX9, SLC34A3, SLC34A1
6	growth/size phenotype	MP:0005378	5.4	NR1I3, PHEX, HBA2, HBB, OCRL, SOX9
7	renal/urinary system phenotype	MP:0005367	4.7	SLC4A1, CASR, HSD11B2, ALB, GRHPR, XDH
8	mortality/aging	MP:0010768	4.7	HBB, HBA2, PHEX, NR1I3, OCRL, SOX9
9	homeostasis/metabolism phenotype	MP:0005376	4.0	SLC4A1, SLC12A3, CA2, CASR, HSD11B2, ALB

Articles related to nephrocalcinosis:

(show all 32)

id	Title	Authors	Year	Affiliating Genes
1	A novel mutation of the claudin 16 gene in familial h ypomagnesemia with hypercalciuria and nephrocalcinosis mimicking rickets. (21848011)	Kasapkara C.S.... Hasanoglu A.	2011	CLDN16
2	Hyperoxaluria is reduced and nephrocalcinosis prevented with an oxalate-degrading enzyme in mice with hyperoxaluria. (18698135)	Grujic D.... Margolin A.L.	2009	AGXT
3	Crystalluric and tubular epithelial parameters during the onset of intratubular nephrocalcinosis: illustration of the 'fixed particl e' theory in vivo. (19717825)	Vervaet B.A.... Verhulst A.	2009	SPP1
4	A novel SOX9 mutation, 972delC, causes 46,XY sex-reversed campomelic dysplasia with nephrocalcinosis, urolithiasis, and dysgerminoma. (19231556)	Cost N.G.... Baker L.A.	2009	SOX9
5	Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis (FHHNC): compound heterozygous mutation in the claudin 16 (CLDN16) gene. (18816383)	Hampson G.... Scoble J.	2008	CLDN16
6	Familial hypomagnesemia with hypercalciuria and nephrocalcinosis in 2 sisters. (18327378)	Al-Elq A.H.	2008	CLDN16
7	Renal tubular dysfunction with nephrocalcinosis in a patient with beta thalassemia minor. (18974585)	Prabahar M.R.... Soundararajan P.	2008	HBB, HBA2
8	Familial hypomagnesemia with hypercalciuria and nephrocalcinosis: report of three Turkish siblings. (18253757)	Peru H.... Konrad M.	2008	CLDN16
9	Nephrocalcinosis in preterm babies. Commentary on Rockwell et al.: preliminary observations of urinary calcium and osteopontin excretion in premature infants, term infants and adults (Neonatology 2008;93:241-245). (18025798)	White M.P.	2008	SPP1
10	Nephrocalcinosis in glucose-galactose malabsorption: nephrocalcinosis and proximal tubular dysfunction in a young infant with a novel mutation of SGLT1. (18288487)	Soylu O.B.... Kasahara M.	2008	SLC5A1
11	CLDN16 genotype predicts renal decline in familial hypomagnesemia with hypercalciuria and nephrocalcinosis. (18003771)	Konrad M.... Schaller A.	2008	CLDN16
12	Hypomagnesemia and nephrocalcinosis in a patient with two heterozygous mutations in the CLDN16 gene. (17347984)	Staiger K.... Haring H.U.	2007	CLDN16
13	Familial hypomagnesemia with hypercalciuria and nephrocalcinosis: blocking endocytosis restores surface expression of a novel Claudin-16 mutant that lacks the entire C-terminal cytosolic tail. (16501001)	Muller D.... Hunziker W.	2006	CLDN16
14	Preconditioning of the distal tubular epithelium of the human kidney precedes nephrocalcinosis. (16164641)	Verhulst A.... De Broe M.E.	2005	SPP1
15	Hypomagnesemia with hypercalciuria and nephrocalcinosis: case report and a family study. (15856319)	Tasic V.... Konrad M.	2005	CLDN16
16	Familial hypomagnesemia with hypercalciuria and nephrocalcinosis associated with CLDN16 mutations. (16047219)	Kang J.H.... Choi Y.	2005	CLDN16
17	Familial hypomagnesemia with hypercalciuria and nephrocalcinosis. Association with ocular abnormalities (15574250)	Loris Pablo C.... Ferrer Novella C.	2004	CLDN16
18	Urinary NAG in children with urolithiasis, nephrocalcinosis, or risk of urolithiasis. (12920632)	Sikora P.... Hoppe B.	2003	NAGLU
19	A novel mutation in the anion exchanger 1 gene is associated with familial distal renal tubular acidosis and nephrocalcinosis. (14654610)	Cheidde L.... Heilberg I.P.	2003	SLC4A1
20	Congenital sucrase-isomaltase deficiency presenting with failure to thrive, hypercalcemia, and nephrocalcinosis. (12014995)	Belmont J.W.... Schwartz I.D.	2002	SI
21	Novel paracellin-1 mutations in 25 families with familial hypomagnesemia with hypercalciuria and nephrocalcinosis. (11518780)	Weber S.... Konrad M.	2001	CLDN16
22	Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis maps to chromosome 3q27 and is associated with mutations in the PCLN-1 gene. (10878661)	Weber S.... Konrad M.	2000	CLDN16
23	Sensorineural hearing loss in distal renal tubular acidosis, nephrocalcinosis and microcytic anemia (11139892)	Ptok M.	2000	ATP6V1B1
24	Microscopic nephrocalcinosis and hypercalciuria in ne phrotic syndrome. (11112210)	Mocan H.... Kuzey G.M.	2000	ALB
25	Is there a role for uric acid in an animal model of calcium phosphate nephrocalcinosis and calcium phosphate crystallization in urine of patients with idiopathic calcium urolithiasis? An orientational study. (10608515)	Schwille P.O.... Wipplinger J.	1999	XDH
26	The role of renal chloride channel mutations in kidney stone disease and nephrocalcinosis. (9690036)	Thakker R.V.	1998	CLCN5, CLCN7, SLC12A3
27	Mutations of CLCN5 in Japanese children with idiopathic low molecular weight proteinuria, hypercalciuria and nephrocalcinosis. (9328929)	Akuta N.... Thakker R.V.	1997	CLCN5
28	Nephrocalcinosis and urolithiasis in carbonic anhydrase II deficiency syndrome. (9453381)	Ismail E.A.... Sabry M.A.	1997	CA2
29	Idiopathic low molecular weight proteinuria associated with hypercalciuric nephrocalcinosis in Japanese children is due to mutations of the renal chloride channel (CLCN5). (9062355)	Lloyd S.E.... Thakker R.V.	1997	CLCN5
30	Hypercalciuria and nephrocalcinosis in patients with idiopathic low-molecular-weight proteinuria in Japan: is the disease identical to Dent's disease in United Kingdom? (7753256)	Igarashi T.... Akagi K.	1995	CLCN5
31	Dent's disease, a renal Fanconi syndrome with nephrocalcinosis and kidney stones, is associated with a microdeletion involving DXS255 and maps to Xp11.22. (8111383)	Pook M.A.... Thakker R.V.	1993	CLCN5
32	Renal magnesium wasting, incomplete tubular acidosis, hypercalciuria and nephrocalcinosis in siblings. (668721)	Manz F.... Lombeck J.	1978	CLDN16

Genes related to nephrocalcinosis according to GeneCards:

(show all 42)

id	Symbol	Description	Score	GeneCards Section Context
1	CLDN16	claudin 16	11.1	Publications, Aliases & Descriptions, Summaries
2	SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	11.1	Summaries, Publications
3	CLDN19	claudin 19	11.0	Summaries
4	CLCN5	chloride channel, voltage-sensitive 5	11.0	Publications
5	GRHPR	glyoxylate reductase/hydroxypyruvate reductase	11.0
6	CLCNKB	chloride channel, voltage-sensitive Kb	11.0	Publications
7	AGXT	alanine-glyoxylate aminotransferase	11.0	Publications
8	SLC34A1	solute carrier family 34 (sodium phosphate), member 1	11.0
9	KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	11.0
10	SLC12A1	solute carrier family 12 (sodium/potassium/chloride transporters), member 1	11.0	Publications
11	UMOD	uromodulin	11.0
12	CA2	carbonic anhydrase II	11.0	Publications
13	NR1I3	nuclear receptor subfamily 1, group I, member 3	11.0
14	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
15	SPP1	secreted phosphoprotein 1	11.0	Publications
16	LRP2	low density lipoprotein receptor-related protein 2	11.0
17	CASR	calcium-sensing receptor	11.0
18	PHEX	phosphate regulating endopeptidase homolog, X-linked	11.0
19	FXYD2	FXYD domain containing ion transport regulator 2	11.0
20	SLC34A3	solute carrier family 34 (sodium phosphate), member 3	11.0
21	SLC26A1	solute carrier family 26 (sulfate transporter), member 1	11.0
22	SIK1	salt-inducible kinase 1	11.0
23	ATP6V1B1	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	11.0	Publications
24	MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	11.0
25	CLCC1	chloride channel CLIC-like 1	11.0
26	SOX9	SRY (sex determining region Y)-box 9	11.0	Publications
27	CLCN1	chloride channel, voltage-sensitive 1	11.0	Publications
28	CLCN7	chloride channel, voltage-sensitive 7	11.0	Publications
29	HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	11.0
30	SLC5A1	solute carrier family 5 (sodium/glucose cotransporter), member 1	11.0	Publications
31	SLC12A3	solute carrier family 12 (sodium/chloride transporters), member 3	11.0	Publications
32	CYP24A1	cytochrome P450, family 24, subfamily A, polypeptide 1	11.0
33	HBA2	hemoglobin, alpha 2	11.0	Publications
34	OCRL	oculocerebrorenal syndrome of Lowe	11.0
35	SI	sucrase-isomaltase (alpha-glucosidase)	11.0	Publications
36	ATP13A4	ATPase type 13A4	11.0
37	TRPM6	transient receptor potential cation channel, subfamily M, member 6	11.0
38	CLDN10	claudin 10	11.0
39	ATP6V0A4	ATPase, H+ transporting, lysosomal V0 subunit a4	11.0
40	HBB	hemoglobin, beta	11.0	Publications
41	XDH	xanthine dehydrogenase	11.0	Publications
42	ALB	albumin	11.0	Publications

Pathways related to nephrocalcinosis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Selected targets of HNF110	9.6	UMOD, ALB, SLC5A1
2	Hepatic ABC Transporters36	9.5	CLCN1, CLCNKB, CLCN5, CLCN7
3	Collecting duct acid secretion20	9.3	SLC4A1, CA2, ATP6V0A4, ATP6V1B1, CLCNKB
4	O2/CO2 exchange in erythrocytes38	9.3	CA2, HBA2, HBB, SLC4A1

Compounds related to nephrocalcinosis according to GeneDecks:

(show top 50)    (show all 55)

id	Compound	Score	Top Affiliating Genes
1	calcium oxalate32	10.4	AGXT, SPP1, UMOD, NAGLU
2	Methyclothiazide9 9	11.3	SLC12A1, CA2
3	Quinethazone9 9	11.3	SLC12A3, SLC12A1, CA2
4	gentamicin32 9 9	12.3	CASR, NAGLU, LRP2
5	glucose32	10.2	UMOD, CASR
6	thiazide32	10.2	SLC12A3, SLC12A1, CA2, CASR
7	oxalate32	10.0	SLC4A1, SLC26A1, AGXT, SPP1, GRHPR, UMOD
8	1,25 dihydroxy vitamin d332	9.9	SLC34A1, PHEX, NR1I3, SPP1, CYP24A1, CASR
9	dansylamide32 9 9	11.9	CA2, ALB
10	sevelamer32	9.8	CASR, ALB
11	bicarbonate32	9.8	SLC4A1, SLC26A1, CA2, ALB
12	urea32 9 18 9	12.8	SLC12A1, CA2, ALB, UMOD, NAGLU
13	23-diphosphoglycerate32	9.8	HBB, HBA2, CA2
14	nacl32	9.7	SLC12A3, SLC12A1, SLC5A1, CASR, UMOD, KCNJ1
15	iopentol32	9.7	ALB, NAGLU
16	citrate32	9.7	SLC4A1, SPP1, CA2, ALB, UMOD, NAGLU
17	neomycin32	9.7	CASR, SPP1, NR1I3, HBB
18	chlorine32 18	10.7	SLC12A3, SLC12A1, CLCN7, CLCN5, CLCNKB, CLCN1
19	25-hydroxyvitamin d32	9.6	SPP1, CYP24A1, CASR, ALB, LRP2
20	phosphorus32	9.6	SLC34A1, PHEX, NR1I3, SPP1, CASR, ALB
21	hydrochlorothiazide32 34 9 18 9	13.5	SLC12A3, CA2, CASR, HSD11B2, ALB, CLDN16
22	hmba32	9.5	HBA2, HBB, SLC5A1
23	furosemide32 42 34 9 18 9	14.4	SLC4A1, SLC12A3, SLC12A1, CA2, HSD11B2, ALB
24	glyceraldehyde 3-phosphate32	9.3	SLC4A1, SLC5A1, SOX9, HBB, CA2
25	malondialdehyde32	9.3	SI, SPP1, XDH, NAGLU
26	spermine32 9 18 9	12.3	SI, PHEX, NR1I3, CASR, XDH
27	lysine32	9.3	SLC4A1, SLC12A3, HBB, NR1I3, CA2, CASR
28	proline32	9.3	SI, SLC5A1, SOX9, HBA2, PHEX, SPP1
29	calcitriol32 42 9 18 9	13.1	SLC34A1, PHEX, NR1I3, SPP1, CYP24A1, CA2
30	vitamin d32	9.1	SLC34A1, PHEX, NR1I3, SPP1, CYP24A1, CASR
31	uric acid32 18	10.1	SPP1, ALB, XDH, UMOD, NAGLU
32	hydrogen32 18	10.1	SI, SLC4A1, SLC5A1, HBB, CA2, CASR
33	potassium32 9 18 9	12.0	SLC4A1, SLC12A3, SLC12A1, CASR, HSD11B2, ALB
34	creatinine32	9.0	OCRL, SPP1, CA2, CASR, HSD11B2, ALB
35	cholesterol32 9 18 9	11.8	SI, SLC4A1, SLC5A1, NR1I3, SPP1, HSD11B2
36	steroid32	8.8	SOX9, HBB, NR1I3, CYP24A1, CA2, HSD11B2
37	aspartate32	8.7	SI, AGXT, HBB, PHEX, SPP1, CA2
38	leucine32	8.7	SI, SLC4A1, SLC12A3, HBB, HBA2, PHEX
39	chloride32	8.4	SI, CLCN1, SLC4A1, SLC12A3, SLC12A1, SLC26A1
40	cyclic amp32 18	9.4	SLC5A1, SOX9, HBB, NR1I3, CYP24A1, CA2
41	magnesium32 9 18 9	11.3	CASR, TRPM6, SPP1, NR1I3, SLC12A1, SIK1
42	arginine32	8.1	SI, HBB, NR1I3, SPP1, CA2, CASR
43	serine32	7.9	SLC12A3, SLC5A1, SOX9, HBB, NR1I3, SPP1
44	lactate32	7.8	SI, SLC4A1, SLC5A1, HBB, SPP1, CA2
45	oxygen32 18	8.7	SI, SOX9, HBB, HBA2, NR1I3, SPP1
46	alanine32	7.6	HBB, AGXT, SLC5A1, SLC12A3, SLC4A1, SI
47	lipid32	7.5	SI, SLC4A1, OCRL, NR1I3, SPP1, CYP24A1
48	sodium32 18	8.5	SLC12A3, SLC12A1, SLC34A1, SLC5A1, PHEX, NR1I3
49	cysteine32	7.2	SI, SLC4A1, SLC5A1, AGXT, HBB, SPP1
50	calcium32 9 18 9	8.1	ALB, GRHPR, FXYD2, ATP6V0A4, ATP6V1B1, UMOD

Cellular components related to nephrocalcinosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	basolateral plasma membrane	GO:016323	9.8	SLC4A1, SLC34A1, CA2, ATP6V1B1, UMOD, CLDN19
2	apical part of cell	GO:045177	9.6	SPP1, CA2, ATP6V0A4, CLCN5
3	cytoplasmic vesicle	GO:031410	9.5	SLC34A3, MAP1LC3B, UMOD, CLCN7
4	haptoglobin-hemoglobin complex	GO:031838	9.5	HBA2, HBB
5	integral to plasma membrane	GO:005887	9.0	SLC12A3, SLC34A1, SLC5A1, PHEX, CASR, CLCN5
6	brush border membrane	GO:031526	9.0	LRP2, SLC34A1, SLC34A3, SLC5A1, TRPM6, ATP6V0A4
7	apical plasma membrane	GO:016324	8.2	SI, SLC12A3, SLC34A3, SLC5A1, TRPM6, ATP6V0A4

Biological processes related to nephrocalcinosis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	neuronal action potential propagation	GO:019227	10.2	CLCN1, CLDN19
2	response to vitamin D	GO:033280	10.0	LRP2, CYP24A1, SPP1
3	sodium ion transport	GO:006814	9.7	SLC12A3, SLC12A1, SLC34A1, SLC34A3
4	ion transport	GO:006811	9.6	SLC4A1, SLC12A3, SLC12A1, SLC26A1, SLC34A1, SLC34A3
5	calcium-independent cell-cell adhesion	GO:016338	9.5	CLDN16, CLDN10, CLDN19
6	bicarbonate transport	GO:015701	9.4	SLC4A1, HBB, HBA2, CA2
7	ossification	GO:001503	9.4	SOX9, CASR, ATP6V0A4, ATP6V1B1
8	excretion	GO:007588	9.4	CLCNKB, GRHPR, ATP6V0A4, ATP6V1B1, UMOD, KCNJ1
9	transport	GO:006810	8.9	SLC12A3, SLC12A1, ALB, FXYD2, CLCN7, CLCN5
10	transmembrane transport	GO:055085	8.1	SLC4A1, SLC12A3, SLC12A1, SLC26A1, SLC34A1, SLC34A3
11	small molecule metabolic process	GO:044281	6.5	HBB, AGXT, OCRL, SLC5A1, SLC4A1, SI

Molecular functions related to nephrocalcinosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	sodium-dependent phosphate transmembrane transporter activity	GO:015321	10.2	SLC34A3, SLC34A1
2	chloride transmembrane transporter activity	GO:015108	10.1	SLC26A1, SLC4A1
3	voltage-gated chloride channel activity	GO:005247	9.9	CLCN1, CLCNKB, CLCN5, CLCN7
4	chloride channel activity	GO:005254	9.8	CLCC1, CLCN1, CLCN5, CLCN7
5	haptoglobin binding	GO:031720	9.6	HBB, HBA2
6	oxygen binding	GO:019825	8.7	ALB, HBA2, HBB