MCID: NPH006
MIFTS: 28

Nephrogenic Adenofibroma

Categories: Nephrological diseases, Cancer diseases

Aliases & Classifications for Nephrogenic Adenofibroma

MalaCards integrated aliases for Nephrogenic Adenofibroma:

Name: Nephrogenic Adenofibroma 12 14 69
Metanephric Adenofibroma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2698
NCIt 47 C39812
SNOMED-CT 64 128760004
UMLS 69 C1266141

Summaries for Nephrogenic Adenofibroma

MalaCards based summary : Nephrogenic Adenofibroma, also known as metanephric adenofibroma, is related to thymus lipoma and adult endodermal sinus tumor. An important gene associated with Nephrogenic Adenofibroma is MAF (MAF BZIP Transcription Factor), and among its related pathways/superpathways are Developmental Biology and Transcriptional misregulation in cancer. Affiliated tissues include kidney, and related phenotypes are Decreased sensitivity to paclitaxel and embryo

Related Diseases for Nephrogenic Adenofibroma

Diseases related to Nephrogenic Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
id Related Disease Score Top Affiliating Genes
1 thymus lipoma 10.9 NCAM1 WT1
2 adult endodermal sinus tumor 10.9 PAX2 PAX8
3 retinitis 10.8 MME PAX2
4 omphalocele 10.8 MYOD1 PAX8
5 plexosarcoma 10.8 MAF NCAM1
6 exotropia 10.8 PAX8 WT1
7 cervical spina bifida cystica 10.7 KRT18 KRT8
8 adult pineoblastoma 10.7 HBA1 WT1
9 eccrine papillary adenoma 10.7 MME PAX8
10 hypotrichosis 13 10.7 KRT18 KRT8
11 nonossifying fibromyxoid tumor 10.7 CALD1 MME
12 prion disease 10.7 NCAM1 PAX2 PAX8
13 gallbladder adenocarcinoma 10.7 MME NCAM1
14 spleen cancer 10.7 MYOD1 NF1
15 infant gynecomastia 10.7 NF1 PAX2
16 trachea sarcoma 10.7 MME NCAM1 PAX2
17 acidophil adenoma 10.6 KRT8 MME PAX2
18 breast apocrine carcinoma in situ 10.6 B3GAT1 NF1
19 endometrial disease 10.5 KRT7 MME
20 ethmoid sinus schneiderian papilloma 10.5 B3GAT1 CHL1 NCAM1
21 urethra clear cell adenocarcinoma 10.5 KRT18 KRT8 NCAM1
22 engraftment syndrome 10.5 KRT7 KRT8
23 ludwig's angina 10.5 KRT7 NCAM1
24 bile duct sarcoma 10.5 MYOD1 MYOG
25 urethral villous adenoma 10.5 MME NCAM1 PAX2 PAX8
26 mucinous adenofibroma 10.4 B3GAT1 NCAM1 PAX2 WT1
27 ovarian stromal hyperthecosis 10.4 KRT7 PAX2 PAX8
28 thymic dysplasia 10.4 PAX2 PAX8
29 biliary tract neoplasm 10.4 KRT7 PAX2 PAX8
30 panophthalmitis 10.4 CALD1 MME
31 fibular collateral ligament bursitis 10.4 KRT7 PAX8 WT1
32 testis seminoma 10.4 MME MYOG
33 dental caries 10.4 KRT7 PAX8 WT1
34 nasal cavity disease 10.4 KRT7 PAX8 WT1
35 primary pulmonary lymphoma 10.4 MYOD1 MYOG
36 phagocyte bactericidal dysfunction 10.4 MYOG NF1
37 familial periodic paralysis 10.4 KRT7 KRT8
38 mediastinum synovial sarcoma 10.3 KRT7 MME NCAM1
39 lateral medullary syndrome 10.3 MYOD1 MYOG WT1
40 ovarian wilms' cancer 10.3 KRT18 MME
41 ischemia 10.3 MYOD1 MYOG WT1
42 dextrocardia with situs inversus 10.3 MYOD1 MYOG WT1
43 dental pulp calcification 10.3 CD34 MME
44 classic variant of chromophobe renal cell carcinoma 10.3 CHL1 KRT7 KRT8
45 prostaglandin-endoperoxide synthase deficiency 10.3 KRT18 KRT7 KRT8
46 rhabdomyosarcoma 2, alveolar 10.3 MYOD1 MYOG WT1
47 trachea adenoid cystic carcinoma 10.3 KRT18 KRT7 KRT8
48 lung benign neoplasm 10.3 B3GAT1 WT1
49 ectodermal dysplasia with natal teeth, turnpenny type 10.3 KRT7 KRT8 NCAM1
50 diffuse lipomatosis 10.2 KRT7 NCAM1

Graphical network of the top 20 diseases related to Nephrogenic Adenofibroma:



Diseases related to Nephrogenic Adenofibroma

Symptoms & Phenotypes for Nephrogenic Adenofibroma

GenomeRNAi Phenotypes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased sensitivity to paclitaxel GR00112-A-0 8.62 NF1 WT1

MGI Mouse Phenotypes related to Nephrogenic Adenofibroma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.56 KRT18 KRT8 MYOG NF1 PAX2 PAX8
2 mortality/aging MP:0010768 9.44 CA9 KRT18 KRT8 MAF MYOD1 MYOG

Drugs & Therapeutics for Nephrogenic Adenofibroma

Search Clinical Trials , NIH Clinical Center for Nephrogenic Adenofibroma

Genetic Tests for Nephrogenic Adenofibroma

Anatomical Context for Nephrogenic Adenofibroma

MalaCards organs/tissues related to Nephrogenic Adenofibroma:

39
Kidney

Publications for Nephrogenic Adenofibroma

Articles related to Nephrogenic Adenofibroma:

id Title Authors Year
1
Nephrogenic adenofibroma in a young child. ( 11156329 )
2000
2
Nephrogenic adenofibroma: an unusual renal tumor. ( 9112535 )
1997
3
Nephrogenic adenofibroma. A novel kidney tumor of young people. ( 1373578 )
1992

Variations for Nephrogenic Adenofibroma

Expression for Nephrogenic Adenofibroma

Search GEO for disease gene expression data for Nephrogenic Adenofibroma.

Pathways for Nephrogenic Adenofibroma

GO Terms for Nephrogenic Adenofibroma

Cellular components related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.13 KRT18 KRT7 KRT8
2 cell periphery GO:0071944 8.8 CD34 KRT18 KRT8

Biological processes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

(show all 28)
id Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.81 MME PAX8 WT1
2 skeletal muscle tissue development GO:0007519 9.71 MYOD1 MYOG NF1
3 branching involved in ureteric bud morphogenesis GO:0001658 9.67 PAX2 PAX8 WT1
4 urogenital system development GO:0001655 9.63 PAX2 PAX8
5 myotube differentiation GO:0014902 9.63 MYOD1 MYOG
6 mesonephros development GO:0001823 9.62 PAX2 PAX8
7 hepatocyte apoptotic process GO:0097284 9.62 KRT18 KRT8
8 cell-cell adhesion GO:0098609 9.61 KRT18 PDLIM5
9 positive regulation of skeletal muscle fiber development GO:0048743 9.61 MYOD1 MYOG
10 mesenchymal to epithelial transition GO:0060231 9.6 PAX2 WT1
11 metanephric mesenchyme development GO:0072075 9.59 PAX2 WT1
12 cellular response to gonadotropin stimulus GO:0071371 9.58 PAX8 WT1
13 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.57 PAX2 PAX8
14 muscle cell fate commitment GO:0042693 9.56 MYOD1 MYOG
15 pronephros development GO:0048793 9.55 PAX2 PAX8
16 metanephric S-shaped body morphogenesis GO:0072284 9.52 PAX8 WT1
17 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.51 PAX2 PAX8
18 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.48 PAX2 PAX8
19 metanephric nephron tubule formation GO:0072289 9.46 PAX2 PAX8
20 metanephric distal convoluted tubule development GO:0072221 9.43 PAX2 PAX8
21 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.4 PAX2 PAX8
22 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.37 PAX2 PAX8
23 positive regulation of metanephric DCT cell differentiation GO:2000594 9.32 PAX2 PAX8
24 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 9.26 PAX2 PAX8
25 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.16 PAX2 PAX8
26 pronephric field specification GO:0039003 8.96 PAX2 PAX8
27 metanephric epithelium development GO:0072207 8.8 PAX2 PAX8 WT1
28 positive regulation of transcription from RNA polymerase II promoter GO:0045944 10.12 MAF MYOD1 MYOG PAX2 PAX8 SS18

Sources for Nephrogenic Adenofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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