MCID: NPH006
MIFTS: 30

Nephrogenic Adenofibroma

Categories: Nephrological diseases, Cancer diseases

Aliases & Classifications for Nephrogenic Adenofibroma

MalaCards integrated aliases for Nephrogenic Adenofibroma:

Name: Nephrogenic Adenofibroma 12 14 69
Metanephric Adenofibroma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2698
NCIt 46 C39812
SNOMED-CT 64 128760004
UMLS 69 C1266141

Summaries for Nephrogenic Adenofibroma

MalaCards based summary : Nephrogenic Adenofibroma, also known as metanephric adenofibroma, is related to fallopian tube carcinosarcoma and childhood endodermal sinus tumor. An important gene associated with Nephrogenic Adenofibroma is MAF (MAF BZIP Transcription Factor), and among its related pathways/superpathways are Developmental Biology and Transcriptional misregulation in cancer. Affiliated tissues include kidney, and related phenotypes are Decreased sensitivity to paclitaxel and embryo

Related Diseases for Nephrogenic Adenofibroma

Diseases related to Nephrogenic Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 fallopian tube carcinosarcoma 10.6 NCAM1 WT1
2 childhood endodermal sinus tumor 10.6 PAX2 PAX8
3 balloon cell malignant melanoma 10.6 KRT7 MME
4 endolymphatic sac tumor 10.6 KRT7 KRT8
5 ovarian large-cell neuroendocrine carcinoma 10.6 KRT7 NCAM1
6 cervix endometriosis 10.5 MME PAX2
7 plasma cell leukemia 10.5 MAF NCAM1
8 female reproductive endometrioid cancer 10.5 KRT7 WT1
9 nephrogenic adenoma of urinary bladder 10.5 KRT7 PAX2 PAX8
10 endosalpingiosis 10.5 KRT7 PAX8 WT1
11 bladder benign neoplasm 10.5 KRT7 PAX2 PAX8
12 nephrogenic adenoma 10.5 KRT7 PAX2 PAX8
13 urethral diverticulum 10.5 KRT7 PAX8 WT1
14 clear cell hidradenoma 10.5 MME PAX8
15 endocervical adenocarcinoma 10.5 KRT7 PAX2 PAX8
16 malignant epithelial mesothelioma 10.5 KRT7 PAX8 WT1
17 adenocarcinoma in situ 10.5 KRT7 PAX2 PAX8
18 neurenteric cyst 10.5 KRT18 KRT8
19 malignant ovarian surface epithelial-stromal neoplasm 10.5 KRT7 PAX8 WT1
20 extrahepatic bile duct adenocarcinoma 10.5 MME NCAM1
21 ovary epithelial cancer 10.5 KRT7 PAX8 WT1
22 hidrocystoma 10.5 KRT7 KRT8
23 angiokeratoma of fordyce 10.5 HBA1 WT1
24 wilms tumor 5 10.4 PAX2 PAX8 WT1
25 rete testis adenoma 10.4 NCAM1 PAX2 PAX8
26 collecting duct carcinoma 10.4 KRT7 MME PAX8
27 prostate squamous cell carcinoma 10.4 KRT7 KRT8
28 malignant triton tumor 10.4 MYOD1 NF1
29 ovarian cancer 1 10.4 KRT7 PAX8 WT1
30 cystadenofibroma 10.4 KRT7 MME NCAM1
31 angioimmunoblastic t-cell lymphoma 10.4 MAF MME
32 mixed endometrial stromal and smooth muscle tumor 10.4 CALD1 MME
33 spermatocele 10.4 MME NCAM1 PAX2
34 metanephric adenoma 10.4 KRT18 KRT7 WT1
35 sweat gland cancer 10.4 KRT7 KRT8 MME
36 scleral staphyloma 10.4 NF1 PAX2
37 malignant glandular tumor of peripheral nerve sheath 10.4 B3GAT1 NF1
38 gastric tubular adenocarcinoma 10.4 CHL1 KRT7 KRT8
39 merkel cell carcinoma 10.4 KRT7 KRT8 NCAM1
40 epithelioid trophoblastic tumor 10.4 KRT18 KRT7
41 proliferating trichilemmal cyst 10.4 KRT18 KRT7 KRT8
42 endocervical carcinoma 10.4 KRT7 PAX8
43 cutaneous adenocystic carcinoma 10.4 KRT18 KRT7 KRT8
44 apocrine sweat gland neoplasm 10.4 KRT7 KRT8
45 pleomorphic carcinoma 10.4 KRT18 KRT7 KRT8
46 adenoid squamous cell carcinoma 10.3 HBA1 KRT7
47 lymphoepithelioma-like carcinoma 10.3 KRT18 KRT7 KRT8
48 mammary paget's disease 10.3 KRT18 KRT7 KRT8
49 primary cutaneous amyloidosis 10.3 KRT18 KRT7 KRT8
50 adenosquamous carcinoma 10.3 KRT18 KRT7 KRT8

Graphical network of the top 20 diseases related to Nephrogenic Adenofibroma:



Diseases related to Nephrogenic Adenofibroma

Symptoms & Phenotypes for Nephrogenic Adenofibroma

GenomeRNAi Phenotypes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased sensitivity to paclitaxel GR00112-A-0 8.62 WT1 NF1

MGI Mouse Phenotypes related to Nephrogenic Adenofibroma:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.56 KRT18 KRT8 MYOG NF1 PAX2 PAX8
2 mortality/aging MP:0010768 9.44 KRT18 KRT8 MAF MYOD1 MYOG NCAM1

Drugs & Therapeutics for Nephrogenic Adenofibroma

Search Clinical Trials , NIH Clinical Center for Nephrogenic Adenofibroma

Genetic Tests for Nephrogenic Adenofibroma

Anatomical Context for Nephrogenic Adenofibroma

MalaCards organs/tissues related to Nephrogenic Adenofibroma:

38
Kidney

Publications for Nephrogenic Adenofibroma

Articles related to Nephrogenic Adenofibroma:

# Title Authors Year
1
Nephrogenic adenofibroma in a young child. ( 11156329 )
2000
2
Nephrogenic adenofibroma: an unusual renal tumor. ( 9112535 )
1997
3
Nephrogenic adenofibroma. A novel kidney tumor of young people. ( 1373578 )
1992

Variations for Nephrogenic Adenofibroma

Expression for Nephrogenic Adenofibroma

Search GEO for disease gene expression data for Nephrogenic Adenofibroma.

Pathways for Nephrogenic Adenofibroma

GO Terms for Nephrogenic Adenofibroma

Cellular components related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 9.13 KRT18 KRT7 KRT8
2 cell periphery GO:0071944 8.8 CD34 KRT18 KRT8

Biological processes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 kidney development GO:0001822 9.81 MME PAX8 WT1
2 skeletal muscle tissue development GO:0007519 9.7 MYOD1 MYOG NF1
3 branching involved in ureteric bud morphogenesis GO:0001658 9.67 PAX2 PAX8 WT1
4 urogenital system development GO:0001655 9.63 PAX2 PAX8
5 myotube differentiation GO:0014902 9.62 MYOD1 MYOG
6 mesonephros development GO:0001823 9.62 PAX2 PAX8
7 hepatocyte apoptotic process GO:0097284 9.61 KRT18 KRT8
8 positive regulation of skeletal muscle fiber development GO:0048743 9.61 MYOD1 MYOG
9 mesenchymal to epithelial transition GO:0060231 9.6 PAX2 WT1
10 metanephric mesenchyme development GO:0072075 9.59 PAX2 WT1
11 cellular response to gonadotropin stimulus GO:0071371 9.58 PAX8 WT1
12 mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0003337 9.57 PAX2 PAX8
13 muscle cell fate commitment GO:0042693 9.56 MYOD1 MYOG
14 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.55 PAX2 PAX8
15 pronephros development GO:0048793 9.54 PAX2 PAX8
16 metanephric S-shaped body morphogenesis GO:0072284 9.51 PAX8 WT1
17 positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis GO:0072108 9.48 PAX2 PAX8
18 metanephric nephron tubule formation GO:0072289 9.46 PAX2 PAX8
19 metanephric distal convoluted tubule development GO:0072221 9.43 PAX2 PAX8
20 negative regulation of mesenchymal cell apoptotic process involved in metanephros development GO:1900212 9.4 PAX2 PAX8
21 positive regulation of metanephric DCT cell differentiation GO:2000594 9.37 PAX2 PAX8
22 negative regulation of apoptotic process involved in metanephric nephron tubule development GO:1900218 9.32 PAX2 PAX8
23 pronephric field specification GO:0039003 9.26 PAX2 PAX8
24 negative regulation of apoptotic process involved in metanephric collecting duct development GO:1900215 9.16 PAX2 PAX8
25 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis GO:0072305 8.96 PAX2 PAX8
26 metanephric epithelium development GO:0072207 8.8 PAX2 PAX8 WT1
27 positive regulation of transcription by RNA polymerase II GO:0045944 10.12 MAF MYOD1 MYOG PAX2 PAX8 SS18

Sources for Nephrogenic Adenofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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