MCID: NPH006
MIFTS: 29

Nephrogenic Adenofibroma malady

Categories: Nephrological diseases, Cancer diseases

Aliases & Classifications for Nephrogenic Adenofibroma

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Aliases & Descriptions for Nephrogenic Adenofibroma:

Name: Nephrogenic Adenofibroma 11 13 68
 
Metanephric Adenofibroma 11

Classifications:



External Ids:

Disease Ontology11 DOID:2698
SNOMED-CT62 128760004
NCIt45 C39812

Summaries for Nephrogenic Adenofibroma

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MalaCards based summary: Nephrogenic Adenofibroma, also known as metanephric adenofibroma, is related to adenosarcoma and testicular yolk sac tumor. An important gene associated with Nephrogenic Adenofibroma is MAF (MAF BZIP Transcription Factor), and among its related pathways are Transcriptional misregulation in cancer and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include kidney, and related mouse phenotypes are Decreased sensitivity to paclitaxel and embryo.

Related Diseases for Nephrogenic Adenofibroma

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Diseases related to Nephrogenic Adenofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 119)
idRelated DiseaseScoreTop Affiliating Genes
1adenosarcoma10.7NCAM1, WT1
2testicular yolk sac tumor10.7PAX2, PAX8
3endometriosis of pelvic peritoneum10.7PAX8, WT1
4acute retinal necrosis syndrome10.7MME, PAX2
5akesson syndrome10.6MAF, MME
6gallbladder signet ring cell adenocarcinoma10.6MME, NCAM1
7cerebrum cancer10.6B3GAT1, WT1
8short stature-deafness-neutrophil dysfunction-dysmorphism syndrome10.6KRT18, KRT8
9ovarian stromal hyperthecosis10.6PAX2, PAX8
10periductal breast myoepitheliosis10.6MME, PAX8
11hypotrichosis 1310.6KRT18, KRT8
12sclerosing hemangioma10.6PAX2, PAX8, WT1
13lymph node palisaded myofibroblastoma10.5CALD1, MME
14tenosynovitis of foot and ankle10.5MME, PAX2, PAX8
15tracheal lymphoma10.5MME, NCAM1, PAX2
16dysembryoplastic neuroepithelial tumor10.5MME, WT1
17klinefelter's syndrome10.5MME, NCAM1, WT1
18nipple neoplasm10.5KRT7, WT1
19retinal melanoma10.5B3GAT1, NF1
20prostate rhabdomyosarcoma10.4MME, MYOD1
21esophageal tuberculosis10.4CALD1, MYOD1
22hyperpituitarism10.4B3GAT1, MME
23familial papillary or follicular thyroid carcinoma10.4KRT7, MME
24malignant secondary hypertension10.4CALD1, MME
25embryonal sarcoma10.4KRT7, KRT8
26ovarian clear cell malignant adenofibroma10.4B3GAT1, CHL1, NCAM1
27bladder clear cell adenocarcinoma10.4KRT18, KRT8, NCAM1
28testis sarcoma10.4MYOD1, MYOG
29familial periodic paralysis10.4KRT7, KRT8
30sarcomatoid renal cell carcinoma10.3KRT7, MME
31ulnar hemimelia10.3PAX2, WT1
32multicentric reticulohistiocytosis10.3KRT7, MME
33angiokeratoma circumscriptum10.3B3GAT1, NF1, WT1
34familial long qt syndrome10.3MYOD1, MYOG
35extragonadal seminoma10.3MME, MYOG
36pancreatic serous cystic neoplasm10.3KRT7, NCAM1
37pediatric ovarian dysgerminoma10.3KRT7, PAX2, PAX8
38biliary tract neoplasm10.3KRT7, PAX2, PAX8
39malignant sertoli-leydig cell tumor10.3KRT7, MME
40carotid artery dissection10.3KRT7, PAX8, WT1
41pyoderma10.3KRT7, PAX8, WT1
42central nervous system vasculitis10.3KRT8, MME, PAX2, PAX8
43sleeping sickness10.3CALD1, KRT18
44liver sarcoma10.3B3GAT1, NCAM1, PAX2, WT1
45bronchus adenoma10.3KRT7, MME, PAX2
46female breast lower-inner quadrant cancer10.3KRT7, MME
47epidermal nevus vitamin d resistant rickets10.3KRT7, KRT8
48ovary epithelial cancer10.3KRT18, MME
49spindle cell rhabdomyosarcoma10.2MYOG, NF1
50granular cell leiomyosarcoma10.2CALD1, MYOG

Graphical network of the top 20 diseases related to Nephrogenic Adenofibroma:



Diseases related to nephrogenic adenofibroma

Symptoms & Phenotypes for Nephrogenic Adenofibroma

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GenomeRNAi Phenotypes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00112-A-010.7NF1, WT1

MGI Mouse Phenotypes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.5KRT18, KRT8, MYOG, NF1, PAX2, PAX8
2MP:00107686.3CA9, KRT18, KRT8, MAF, MYOD1, MYOG

Drugs & Therapeutics for Nephrogenic Adenofibroma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Nephrogenic Adenofibroma

Genetic Tests for Nephrogenic Adenofibroma

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Anatomical Context for Nephrogenic Adenofibroma

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MalaCards organs/tissues related to Nephrogenic Adenofibroma:

36
Kidney

Publications for Nephrogenic Adenofibroma

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Articles related to Nephrogenic Adenofibroma:

idTitleAuthorsYear
1
Nephrogenic adenofibroma in a young child. (11156329)
2000
2
Nephrogenic adenofibroma: an unusual renal tumor. (9112535)
1997
3
Nephrogenic adenofibroma. A novel kidney tumor of young people. (1373578)
1992

Variations for Nephrogenic Adenofibroma

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Expression for genes affiliated with Nephrogenic Adenofibroma

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Search GEO for disease gene expression data for Nephrogenic Adenofibroma.

Pathways for genes affiliated with Nephrogenic Adenofibroma

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GO Terms for genes affiliated with Nephrogenic Adenofibroma

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Cellular components related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.8KRT18, KRT7, KRT8
2cell peripheryGO:00719449.6CD34, KRT18, KRT8
3keratin filamentGO:00450959.3KRT18, KRT7, KRT8

Biological processes related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1mesenchymal to epithelial transitionGO:006023110.8PAX2, WT1
2metanephric mesenchyme developmentGO:007207510.8PAX2, WT1
3cellular response to gonadotropin stimulusGO:007137110.8PAX8, WT1
4metanephric S-shaped body morphogenesisGO:007228410.8PAX8, WT1
5mesenchymal to epithelial transition involved in metanephros morphogenesisGO:000333710.8PAX2, PAX8
6mesonephros developmentGO:000182310.8PAX2, PAX8
7metanephric distal convoluted tubule developmentGO:007222110.8PAX2, PAX8
8metanephric nephron tubule formationGO:007228910.8PAX2, PAX8
9negative regulation of apoptotic process involved in metanephric collecting duct developmentGO:190021510.8PAX2, PAX8
10negative regulation of apoptotic process involved in metanephric nephron tubule developmentGO:190021810.8PAX2, PAX8
11negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesisGO:007230510.8PAX2, PAX8
12negative regulation of mesenchymal cell apoptotic process involved in metanephros developmentGO:190021210.8PAX2, PAX8
13positive regulation of branching involved in ureteric bud morphogenesisGO:009019010.8PAX2, PAX8
14positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesisGO:007210810.8PAX2, PAX8
15positive regulation of metanephric DCT cell differentiationGO:200059410.8PAX2, PAX8
16pronephric field specificationGO:003900310.7PAX2, PAX8
17pronephros developmentGO:004879310.7PAX2, PAX8
18regulation of metanephric nephron tubule epithelial cell differentiationGO:007230710.7PAX2, PAX8
19hepatocyte apoptotic processGO:009728410.6KRT18, KRT8
20branching involved in ureteric bud morphogenesisGO:000165810.6PAX2, PAX8, WT1
21metanephric epithelium developmentGO:007220710.6PAX2, PAX8, WT1
22kidney developmentGO:000182210.5MME, PAX8, WT1
23muscle cell fate commitmentGO:004269310.4MYOD1, MYOG
24myoblast differentiationGO:004544510.4MYOD1, MYOG
25myotube differentiationGO:001490210.4MYOD1, MYOG
26positive regulation of myoblast fusionGO:190174110.4MYOD1, MYOG
27positive regulation of skeletal muscle fiber developmentGO:004874310.4MYOD1, MYOG
28urogenital system developmentGO:000165510.0PAX2, PAX8
29skeletal muscle tissue developmentGO:00075199.9MYOD1, MYOG, NF1
30transcription from RNA polymerase II promoterGO:00063669.7MAF, MYOD1, PAX2, PAX8, WT1
31positive regulation of transcription, DNA-templatedGO:00458939.6MYOD1, MYOG, PAX2, PAX8, WT1
32positive regulation of transcription from RNA polymerase II promoterGO:00459449.0MAF, MYOD1, MYOG, PAX2, PAX8, SS18

Molecular functions related to Nephrogenic Adenofibroma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:00435659.5MAF, MYOD1, MYOG, PAX8, WT1
2transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012289.4MAF, MYOD1, MYOG

Sources for Nephrogenic Adenofibroma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet