NDI
MCID: NPH007
MIFTS: 70

Nephrogenic Diabetes Insipidus (NDI) malady

Genetic diseases, Rare diseases, Nephrological diseases categories

Summaries for Nephrogenic Diabetes Insipidus

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22Genetics Home Reference, 44NIH Rare Diseases, 66Wikipedia, 48OMIM, 20GeneReviews, 34MalaCards
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NIH Rare Diseases:44 Nephrogenic diabetes insipidus is a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine. nephrogenic diabetes insipidus occurs when the kidney tubules, which allow water to be removed from the body or reabsorbed, do not respond to a chemical in the body called antidiuretic hormone (adh) or vasopressin. adh normally tells the kidneys to make the urine more concentrated. as a result of the defect, the kidneys release an excessive amount of water into the urine, producing a large quantity of very dilute urine.nephrogenic diabetes insipidus can be either acquired or hereditary. the acquired form is brought on by certain drugs and chronic diseases and can occur at any time during life. the hereditary form is caused by genetic mutations, and its signs and symptoms usually become apparent within the first few months of life. last updated: 7/31/2011

MalaCards: Nephrogenic Diabetes Insipidus, also known as diabetes insipidus nephrogenic x-linked, is related to diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis. An important gene associated with Nephrogenic Diabetes Insipidus is AVPR2 (arginine vasopressin receptor 2), and among its related pathways are Diuretics Pathway, Pharmacodynamics and Ion channel transport. The compounds d[leu4,lys8]-vp and (d(ch2)51,tyr(me)2,arg8)-vasopressin have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and brain, and related mouse phenotypes are mortality/aging and renal/urinary system.

Genetics Home Reference:22 Nephrogenic diabetes insipidus is a disorder of water balance. The body normally balances fluid intake with the excretion of fluid in urine. However, people with nephrogenic diabetes insipidus produce too much urine (polyuria), which causes them to be excessively thirsty (polydipsia). Affected individuals can quickly become dehydrated if they do not drink enough water, especially in hot weather or when they are sick.

Wikipedia:66 Nephrogenic diabetes insipidus is a form of diabetes insipidus primarily due to pathology of the kidney.... more...

Description from OMIM:48 304800,125800

GeneReviews summary for ndi

Aliases & Classifications for Nephrogenic Diabetes Insipidus

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9Disease Ontology, 10diseasecard, 20GeneReviews, 44NIH Rare Diseases, 21GeneTests, 23GTR, 22Genetics Home Reference, 48OMIM, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 36MeSH, 28ICD9CM, 59SNOMED-CT, 41NCIt, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Nephrological diseases
Orphanet: 50 
Rare renal diseases


Characteristics (Orphanet epidemiological data):

50
nephrogenic diabetes insipidus:
Inheritance: Autosomal dominant,Autosomal recessive,X-linked recessive; Prevalence: 1-9/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

nephrogenic diabetes insipidus 9 20 44 22 11 50 63
diabetes insipidus nephrogenic x-linked 44 21 23
diabetes insipidus, nephrogenic 10 22 48
diabetes insipidus nephrogenic 44 21 46
congenital nephrogenic diabetes insipidus 22 63
vasopressin-resistant diabetes insipidus 44 22
nephrogenic diabetes insipidus, type i 63
diabetes insipidus nephrogenic type 1 44
adh-resistant diabetes insipidus 22
adh resistant diabetes insipidus 44
central diabetes insipidus 63
diabetes insipidus renalis 22
ndi 22


External Ids:

Disease Ontology9 DOID:12387
MeSH36 D018500
ICD9CM28 588.1
NCIt41 C84919
MESH via Orphanet37 D018500
ICD10 via Orphanet27 N25.1
SNOMED-CT via Orphanet60 111395007
UMLS via Orphanet64 C0162283
ICD1026 N25.1

Related Diseases for Nephrogenic Diabetes Insipidus

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18GeneCards, 19GeneDecks
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Diseases related to Nephrogenic Diabetes Insipidus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus32.4AVPR2, AVP, AQP2
2nephrogenic syndrome of inappropriate antidiuresis30.5AVPR2
3l1 syndrome30.5L1CAM
4renal tubular acidosis10.7
5hydronephrosis10.7
6fanconi syndrome10.6
7nephrocalcinosis10.6
8hyperparathyroidism10.6
9nephrogenic diabetes insipidus, autosomal10.6
10rickets10.5
11nephritis10.5
12nephrogenic diabetes insipidus - intracranial calcification10.5
13ureteral obstruction10.4
14acquired immunodeficiency syndrome10.4
15hypervitaminosis d10.4
16bladder neck obstruction10.4
17arc syndrome10.4
18hydrocephalus10.4
19interstitial nephritis10.4
20diabetes insipidus nephrogenic mental retardation and intracerebral calcification10.4
21urethritis10.3
22cystinosis10.3
23neuronitis10.3
24hemochromatosis10.3
25central pontine myelinolysis10.3
26polyhydramnios10.3
27pseudopseudohypoparathyroidism10.3
28primary hyperparathyroidism10.3
29proteus syndrome10.3
30cerebritis10.3
31hypoparathyroidism10.3
32fabry disease10.3
33fragile x syndrome10.3
34albright's hereditary osteodystrophy10.3
35neuroleptic malignant syndrome10.3
36hypokalemic periodic paralysis10.3
37werdnig-hoffmann disease10.3
38amyloidosis10.3
39arthritis10.3
40hepatitis10.3
41hyperthyroidism10.3
42hypothyroidism10.3
43intellectual disability10.3
44leiomyosarcoma10.3
45lipoma10.3
46lung cancer10.3
47multiple myeloma10.3
48myeloma10.3
49prostate cancer10.3
50prostatitis10.3

Graphical network of the top 20 diseases related to Nephrogenic Diabetes Insipidus:



Diseases related to nephrogenic diabetes insipidus

Symptoms for Nephrogenic Diabetes Insipidus

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48OMIM
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Symptoms by clinical synopsis from OMIM:

125800

Clinical features from OMIM:

304800,125800

Drugs & Therapeutics for Nephrogenic Diabetes Insipidus

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Nephrogenic Diabetes Insipidus

Drug clinical trials:

Search ClinicalTrials for Nephrogenic Diabetes Insipidus

Search NIH Clinical Center for Nephrogenic Diabetes Insipidus

Search CenterWatch for Nephrogenic Diabetes Insipidus

Genetic Tests for Nephrogenic Diabetes Insipidus

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21GeneTests, 23GTR
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Genetic tests related to Nephrogenic Diabetes Insipidus:

id Genetic test Affiliating Genes
1 Nephrogenic Diabetes Insipidus21 AVPR2
2 Nephrogenic Diabetes Insipidus, X-Linked21 23 AVPR2

Anatomical Context for Nephrogenic Diabetes Insipidus

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34MalaCards
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MalaCards organs/tissues related to Nephrogenic Diabetes Insipidus:

34
Kidney, Testes, Brain, Bone marrow, Bone, Lung, Prostate

Animal Models for Nephrogenic Diabetes Insipidus or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Nephrogenic Diabetes Insipidus:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107688.3AQP2, L1CAM, BSND, AVP, AVPR2
2MP:00053678.3AQP2, CLCNKA, BSND, AVP, AVPR2
3MP:00053868.2AVPR2, AVP, BSND, L1CAM, AQP2
4MP:00053788.1AVPR2, BSND, GPBAR1, L1CAM, AQP2
5MP:00053767.7AVPR2, AVP, BSND, GPBAR1, CLCNKA, AQP2

Publications for Nephrogenic Diabetes Insipidus

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53PubMed
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Articles related to Nephrogenic Diabetes Insipidus:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Nephrogenic diabetes insipidus with intracranial calcification in a child with thalassemia minor. (24053747)
2013
2
Inherited secondary nephrogenic diabetes insipidus: concentrating on humans. (23364801)
2013
3
Novel compound aquaporin 2 mutations in nephrogenic diabetes insipidus. (22249485)
2012
4
Identification and characterization of a novel X-linked AVPR2 mutation causing partial nephrogenic diabetes insipidus: a case report and review of the literature. (22386940)
2012
5
ARC syndrome with complex renal problems: nephrocalcinosis, proximal and hyperkalemic distal RTA and nephrogenic diabetes insipidus. (22805396)
2012
6
Metabolic profiling of kidney and urine in rats with lithium-induced nephrogenic diabetes insipidus by (1)H-NMR-based metabonomics. (19923409)
2010
7
Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus. (19367330)
2009
8
Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus. (19729439)
2009
9
Compound heterozygous mutation of aquaporin 2 gene in woman patient with congenital nephrogenic diabetes insipidus. (19293543)
2009
10
Nephrogenic diabetes insipidus (NDI): clinical, laboratory and genetic characterization of five Brazilian patients. (19488606)
2009
11
Identification of two novel aquaporin-2 mutations in a Thai girl with congenital nephrogenic diabetes insipidus. (18473191)
2008
12
AVPR2 variants and mutations in nephrogenic diabetes insipidus: review and missense mutation significance. (18726898)
2008
13
Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus. (18216143)
2008
14
Treating lithium-induced nephrogenic diabetes insipidus with a COX-2 inhibitor improves polyuria via upregulation of AQP2 and NKCC2. (18216147)
2008
15
Acquired nephrogenic diabetes insipidus. (16713497)
2006
16
Pemetrexed-induced acute renal failure, nephrogenic diabetes insipidus, and renal tubular acidosis in a patient with non-small cell lung cancer. (17018900)
2006
17
A novel mechanism in recessive nephrogenic diabetes insipidus: wild- type aquaporin-2 rescues the apical membrane expression of intracellularly retained AQP2-P262L. (15509592)
2004
18
Changes of rat kidney AQP2 and Na,K-ATPase mRNA expression in lithium-induced nephrogenic diabetes insipidus. (15153756)
2004
19
Methotrexate-induced nephrogenic diabetes insipidus: first case report. (11886979)
2002
20
Water intake and 24-hour blood pressure monitoring in a patient with nephrogenic diabetes insipidus caused by a novel mutation of the vasopressin V2R gene. (11868598)
2002
21
Nephrogenic diabetes insipidus associated with mutations of vasopressin V2 receptors and aquaporin-2]. (11857925)
2002
22
Nephrogenic diabetes insipidus associated with hemochromatosis. (12148115)
2002
23
Lithium-induced nephrogenic diabetes insipidus in older people. (11509315)
2001
24
Lithium-induced nephrogenic diabetes insipidus. (11246113)
2001
25
Misfolded vasopressin V2 receptors caused by extracellular point mutations entail congenital nephrogenic diabetes insipidus. (11026555)
2000
26
Nephrogenic diabetes insipidus in a dog with intestinal leiomyosarcoma. (10613214)
1999
27
Nephrogenic diabetes insipidus. (10435672)
1999
28
Nephrogenic diabetes insipidus due to a new mutation of the arginine vasopressin V2 receptor gene in a girl presenting with non-accidental injury. (10586320)
1999
29
Urinary content of aquaporin 1 and 2 in nephrogenic diabetes insipidus. (8793791)
1996
30
Cognitive and psychosocial functioning of patients with congenital nephrogenic diabetes insipidus. (8741926)
1996
31
Lithium-induced nephrogenic diabetes insipidus treated with intravenous ketorolac. (7587271)
1995
32
Nephrogenic diabetes insipidus secondary to lithium therapy in the postoperative patient: a case report. (7978676)
1994
33
Nephrogenic diabetes insipidus: an X chromosome-linked dominant inheritance pattern with a vasopressin type 2 receptor gene that is structurally normal. (8078903)
1994
34
Prevention of intracranial calcifications and brain damage associated with nephrogenic diabetes insipidus. (8018512)
1994
35
X-linked nephrogenic diabetes insipidus mutations in North America and the Hopewell hypothesis. (8104196)
1993
36
Normal hemodynamic and coagulation responses to 1-deamino-8-D-arginine vasopressin in a case of lithium-induced nephrogenic diabetes insipidus. Results of treatment by a prostaglandin synthesis inhibitor (indomethacin). (1490662)
1992
37
Hereditary nephrogenic diabetes insipidus. (2063710)
1991
38
Nonobstructive urinary tract dilatation in nephrogenic diabetes insipidus. (2076930)
1990
39
Hemodynamic and coagulation responses to 1-desamino[8-D-arginine] vasopressin in patients with congenital nephrogenic diabetes insipidus. (2965301)
1988
40
Expression of a metallothionein-vasopressin fusion gene in transgenic mice produces hypervasopressinemia and manifestations of nephrogenic diabetes insipidus. (3269675)
1988
41
Localization of the gene for X-linked nephrogenic diabetes insipidus to Xq28. (2894172)
1988
42
Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus. (3970081)
1985
43
Lack of intramembranous particle clusters in collecting ducts of mice with nephrogenic diabetes insipidus. (4051007)
1985
44
Absence of overlapping resistance to vasopressin and parathyroid hormone in patients with nephrogenic diabetes insipidus and pseudohypoparathyroidism. (7107814)
1982
45
Nephrogenic diabetes insipidus associated with Dyazide (triamterene-hydrochlorothiazide). (6794799)
1981
46
Post-obstructive diuresis in nephrogenic diabetes insipidus associated with bladder neck obstruction. (423345)
1979
47
Vasopressin-resistant nephrogenic diabetes insipidus. A result of amphotericin B therapy. (760689)
1979
48
Nephrogenic diabetes insipidus and Werdnig-Hoffmann disease in a child: an unusual association. (671487)
1978
49
The mechanism of urinary concentration in nephrogenic diabetes insipidus. (188007)
1977
50
Drug-induced states of nephrogenic diabetes insipidus. (181631)
1976

Variations for Nephrogenic Diabetes Insipidus

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Nephrogenic Diabetes Insipidus:

65 (show all 108)
id Symbol AA change Variation ID SNP ID
1AQP2p.Gly64ArgVAR_004401
2AQP2p.Arg187CysVAR_004402
3AQP2p.Ser216ProVAR_004403
4AQP2p.Leu22ValVAR_015239
5AQP2p.Leu28ProVAR_015240
6AQP2p.Ala47ValVAR_015241
7AQP2p.Asn68SerVAR_015242
8AQP2p.Val71MetVAR_015243
9AQP2p.Thr125MetVAR_015244
10AQP2p.Thr126MetVAR_015245
11AQP2p.Ala147ThrVAR_015246
12AQP2p.Val168MetVAR_015247
13AQP2p.Gly175ArgVAR_015248
14AQP2p.Cys181TrpVAR_015249
15AQP2p.Pro185AlaVAR_015250
16AQP2p.Ala190ThrVAR_015251
17AQP2p.Trp202CysVAR_015253
18AQP2p.Glu258LysVAR_015254
19AQP2p.Pro262LeuVAR_015255
20AQP2p.Gln57ProVAR_015256rs28931580
21AQP2p.Gly100ValVAR_015257rs28929477
22AQP2p.Ala70AspVAR_062585
23AQP2p.Gly100ArgVAR_062586
24AQP2p.Gly180SerVAR_062587
25AQP2p.Arg187HisVAR_062588
26AQP2p.Arg254LeuVAR_062589
27AQP2p.Arg254GlnVAR_062590
28AVPR2p.Leu44ProVAR_003517
29AVPR2p.His80ArgVAR_003520
30AVPR2p.Val88MetVAR_003521
31AVPR2p.Arg106CysVAR_003522
32AVPR2p.Cys112ArgVAR_003523
33AVPR2p.Arg113TrpVAR_003524rs28935496
34AVPR2p.Ser126PheVAR_003525
35AVPR2p.Tyr128SerVAR_003526
36AVPR2p.Ala132AspVAR_003527
37AVPR2p.Arg137HisVAR_003528
38AVPR2p.Arg143ProVAR_003529
39AVPR2p.Trp164SerVAR_003531
40AVPR2p.Ser167LeuVAR_003532
41AVPR2p.Ser167ThrVAR_003533
42AVPR2p.Arg181CysVAR_003534
43AVPR2p.Gly185CysVAR_003535
44AVPR2p.Arg202CysVAR_003536
45AVPR2p.Arg203CysVAR_003537
46AVPR2p.Tyr205CysVAR_003538
47AVPR2p.Tyr280CysVAR_003541
48AVPR2p.Pro286LeuVAR_003543
49AVPR2p.Pro286ArgVAR_003544
50AVPR2p.Leu292ProVAR_003545
51AVPR2p.Leu309ProVAR_003546
52AVPR2p.Asn317LysVAR_003547
53AVPR2p.Trp323SerVAR_003548
54AVPR2p.Leu43ProVAR_015297
55AVPR2p.Ile46LysVAR_015298
56AVPR2p.Leu53ArgVAR_015299
57AVPR2p.Asn55AspVAR_015300
58AVPR2p.Asn55HisVAR_015301
59AVPR2p.Leu59ProVAR_015302
60AVPR2p.Leu62ProVAR_015304
61AVPR2p.Leu81PheVAR_015305
62AVPR2p.Leu83ProVAR_015306
63AVPR2p.Leu83GlnVAR_015307
64AVPR2p.Ala84AspVAR_015308
65AVPR2p.Asp85AsnVAR_015309
66AVPR2p.Gln92ArgVAR_015310
67AVPR2p.Leu94GlnVAR_015311
68AVPR2p.Pro95LeuVAR_015312
69AVPR2p.Trp99ArgVAR_015313
70AVPR2p.Arg104CysVAR_015314
71AVPR2p.Phe105ValVAR_015315
72AVPR2p.Gly107GluVAR_015316
73AVPR2p.Cys112TyrVAR_015317
74AVPR2p.Gly122ArgVAR_015318
75AVPR2p.Met123LysVAR_015319
76AVPR2p.Ser127PheVAR_015320
77AVPR2p.Ile130PheVAR_015321
78AVPR2p.Leu135ProVAR_015322
79AVPR2p.Ala163ProVAR_015324
80AVPR2p.Pro173SerVAR_015325
81AVPR2p.Gln174LeuVAR_015326
82AVPR2p.Asp191GlyVAR_015327
83AVPR2p.Gly201AspVAR_015328
84AVPR2p.Thr204AsnVAR_015329
85AVPR2p.Val206AspVAR_015330
86AVPR2p.Thr207AsnVAR_015331
87AVPR2p.Ile209PheVAR_015332
88AVPR2p.Phe214SerVAR_015333
89AVPR2p.Pro217ThrVAR_015335
90AVPR2p.Leu219ProVAR_015336
91AVPR2p.Leu219ArgVAR_015337
92AVPR2p.Met272LysVAR_015339
93AVPR2p.Val277AlaVAR_015340
94AVPR2p.Leu282ProVAR_015341
95AVPR2p.Pro286SerVAR_015342
96AVPR2p.Phe287LeuVAR_015343
97AVPR2p.Leu289ProVAR_015344
98AVPR2p.Ala294ProVAR_015345
99AVPR2p.Leu309ArgVAR_015346
100AVPR2p.Ser315ArgVAR_015347
101AVPR2p.Cys319ArgVAR_015349
102AVPR2p.Asn321AspVAR_015350
103AVPR2p.Asn321LysVAR_015351
104AVPR2p.Asn321TyrVAR_015352
105AVPR2p.Pro322HisVAR_015353
106AVPR2p.Pro322SerVAR_015354
107AVPR2p.Trp323ArgVAR_015355
108AVPR2p.Gly122AspVAR_062591

Clinvar genetic disease variations for Nephrogenic Diabetes Insipidus:

1 (show all 19)
id Gene Name Type Significance SNP ID Assembly Location
1AVPR2AVPR2, 1-BP DEL, 733GdeletionPathogenic
2AVPR2NM_000054.4(AVPR2): c.395C> A (p.Ala132Asp)single nucleotide variantPathogenicrs104894747GRCh37Chr X, 153171355: 153171355
3AVPR2NM_000054.4(AVPR2): c.553G> T (p.Gly185Cys)single nucleotide variantPathogenicrs104894748GRCh37Chr X, 153171513: 153171513
4AVPR2NM_000054.4(AVPR2): c.614A> G (p.Tyr205Cys)single nucleotide variantPathogenicrs104894749GRCh37Chr X, 153171574: 153171574
5AVPR2NM_000054.4(AVPR2): c.607C> T (p.Arg203Cys)single nucleotide variantPathogenicrs104894750GRCh37Chr X, 153171567: 153171567
6AVPR2NM_000054.4(AVPR2): c.337C> T (p.Arg113Trp)single nucleotide variantPathogenicrs28935496GRCh37Chr X, 153171297: 153171297
7AVPR2AVPR2, 1-BP INSinsertionPathogenic
8AVPR2NM_000054.4(AVPR2): c.213G> A (p.Trp71Ter)single nucleotide variantPathogenicrs104894751GRCh37Chr X, 153171173: 153171173
9AVPR2NM_000054.4(AVPR2): c.839A> G (p.Tyr280Cys)single nucleotide variantPathogenicrs104894752GRCh37Chr X, 153171799: 153171799
10AVPR2NM_000054.4(AVPR2): c.1009C> T (p.Arg337Ter)single nucleotide variantPathogenicrs104894753GRCh37Chr X, 153172075: 153172075
11AVPR2NM_000054.4(AVPR2): c.253G> A (p.Asp85Asn)single nucleotide variantPathogenicrs104894754GRCh37Chr X, 153171213: 153171213
12AVPR2NM_000054.4(AVPR2): c.602G> A (p.Gly201Asp)single nucleotide variantPathogenicrs104894755GRCh37Chr X, 153171562: 153171562
13AVPR2AVPR2, 1-BP INS, 804GinsertionPathogenic
14AVPR2AVPR2, 1-BP DEL, 102GdeletionPathogenic
15AVPR2NM_000054.4(AVPR2): c.410G> A (p.Arg137His)single nucleotide variantPathogenicrs104894756GRCh37Chr X, 153171370: 153171370
16AVPR2NM_000054.4(AVPR2): c.541C> T (p.Arg181Cys)single nucleotide variantPathogenicrs104894757GRCh37Chr X, 153171501: 153171501
17AVPR2NM_000054.4(AVPR2): c.313T> G (p.Phe105Val)single nucleotide variantPathogenicrs104894758GRCh37Chr X, 153171273: 153171273
18AVPR2NM_000054.4(AVPR2): c.137T> A (p.Ile46Lys)single nucleotide variantPathogenicrs104894759GRCh37Chr X, 153171097: 153171097
19AVPR2NM_000054.4(AVPR2): c.310C> T (p.Arg104Cys)single nucleotide variantLikely pathogenic, Pathogenicrs104894760GRCh37Chr X, 153171270: 153171270

Expression for genes affiliated with Nephrogenic Diabetes Insipidus

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephrogenic Diabetes Insipidus

Search GEO for disease gene expression data for Nephrogenic Diabetes Insipidus.

Pathways for genes affiliated with Nephrogenic Diabetes Insipidus

About this section
Sources:
51PathCards, 52PharmGKB, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 61Thomson Reuters
See all sources

Pathways related to Nephrogenic Diabetes Insipidus according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4BSND, CLCNKA
2
Show member pathways
9.4BSND, CLCNKA
39.2AVPR2, AVP, AQP2
4
Show member pathways
9.2GPBAR1, AVP, AVPR2
59.2GPBAR1, AVP, AVPR2
6
Show member pathways
8.4MIP, AVP, AQP2, AVPR2
7
Show member pathways
7.4BSND, MIP, AQP2, CLCNKA, AVPR2, AVP

Compounds for genes affiliated with Nephrogenic Diabetes Insipidus

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Sources:
62Tocris Bioscience, 30IUPHAR, 46Novoseek, 52PharmGKB, 25HMDB, 12DrugBank
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Compounds related to Nephrogenic Diabetes Insipidus according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1d[leu4,lys8]-vp6210.0AVPR2, AVP
2(d(ch2)51,tyr(me)2,arg8)-vasopressin6210.0AVPR2, AVP
3[arg8]-vasopressin6210.0AVPR2, AVP
4sr 4905962 3010.9AVPR2, AVP
5furosemide46 62 30 52 25 1214.9BSND, AQP2
6hgcl2469.6MIP, AQP2
7desmopressin46 62 30 1212.6AQP2, AVP, AVPR2
8chlorine46 2510.6CLCNKA, BSND
9hg2+309.6MIP, AQP2
10mercury469.5MIP, AQP2
11adenylate469.5AQP2, GPBAR1, AVPR2
12abscisic acid469.4MIP, AVP
13urea46 25 1211.3MIP, AQP2
14carbon469.1MIP, AVP
15threonine469.0AQP2, GPBAR1, AVP
16alanine468.9AQP2, AVP, AVPR2
17dexamethasone46 52 30 1211.9AVP, AQP2, MIP
18cyclic amp46 259.8AVPR2, GPBAR1, AQP2, MIP
19nitric oxide46 25 1210.8AVP, AQP2, MIP
20arginine468.7AVPR2, AVP, AQP2, MIP
21cysteine468.7AVPR2, AVP, AQP2, MIP
22nacl468.6BSND, CLCNKA, AQP2, MIP
23glutamate468.5AVPR2, AVP, L1CAM, MIP
24glucose468.5MIP, AQP2, GPBAR1, AVP
25potassium46 25 1210.3AVPR2, BSND, CLCNKA, AQP2, MIP
26tyrosine468.1AVPR2, AVP, GPBAR1, L1CAM, MIP
27chloride467.8MIP, AQP2, CLCNKA, BSND, AVP, AVPR2
28sodium46 258.8AVPR2, AVP, BSND, CLCNKA, AQP2, MIP
29calcium46 52 25 1210.3AVPR2, AVP, BSND, GPBAR1, CLCNKA, AQP2

GO Terms for genes affiliated with Nephrogenic Diabetes Insipidus

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Sources:
17Gene Ontology
See all sources

Cellular components related to Nephrogenic Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:0163239.7AQP2, BSND
2integral component of plasma membraneGO:0058878.0MIP, CLCNKA, BSND, AVPR2
3plasma membraneGO:0058866.8MIP, AVPR2, BSND, GPBAR1, L1CAM, CLCNKA

Biological processes related to Nephrogenic Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of gene expressionGO:0106289.6AVP, AVPR2
2positive regulation of systemic arterial blood pressureGO:0030849.3AVP, AVPR2
3excretionGO:0075889.0AVPR2, CLCNKA, AQP2
4water transportGO:0068338.5MIP, AQP2, AVP, AVPR2
5transmembrane transportGO:0550857.4AVPR2, AVP, BSND, CLCNKA, AQP2, MIP

Products for genes affiliated with Nephrogenic Diabetes Insipidus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nephrogenic Diabetes Insipidus

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet