NDI
MCID: NPH007
MIFTS: 65

Nephrogenic Diabetes Insipidus (NDI) malady

Nephrological category

Summaries for Nephrogenic Diabetes Insipidus

Sources:
43NIH Rare Diseases, 21Genetics Home Reference, 64Wikipedia, 47OMIM, 19GeneReviews, 33MalaCards
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NIH Rare Diseases:43 Nephrogenic diabetes insipidus is a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine. nephrogenic diabetes insipidus occurs when the kidney tubules, which allow water to be removed from the body or reabsorbed, do not respond to a chemical in the body called antidiuretic hormone (adh) or vasopressin. adh normally tells the kidneys to make the urine more concentrated. as a result of the defect, the kidneys release an excessive amount of water into the urine, producing a large quantity of very dilute urine.nephrogenic diabetes insipidus can be either acquired or hereditary. the acquired form is brought on by certain drugs and chronic diseases and can occur at any time during life. the hereditary form is caused by genetic mutations, and its signs and symptoms usually become apparent within the first few months of life. last updated: 7/31/2011

MalaCards: Nephrogenic Diabetes Insipidus, also known as diabetes insipidus nephrogenic x-linked, is related to diabetes insipidus and neurogenic diabetes insipidus. An important gene associated with Nephrogenic Diabetes Insipidus is AVPR2 (arginine vasopressin receptor 2), and among its related pathways are Vasopressin-regulated water reabsorption and Vasopressin-like receptors. The compounds d(ch2)5[tyr(et)2,val4,des-gly9]avp and [phaa1,d-tyr(et)2,val4,lys6,tyr-nh28,des-gly9]avp have been mentioned in the context of this disorder. Affiliated tissues include brain, kidney and lung, and related mouse phenotypes are behavior/neurological and renal/urinary system.

Genetics Home Reference:21 Nephrogenic diabetes insipidus is a disorder of water balance. The body normally balances fluid intake with the excretion of fluid in urine. However, people with nephrogenic diabetes insipidus produce too much urine (polyuria), which causes them to be excessively thirsty (polydipsia). Affected individuals can quickly become dehydrated if they do not drink enough water, especially in hot weather or when they are sick.

Wikipedia:64 Nephrogenic diabetes insipidus is a form of diabetes insipidus primarily due to pathology of the kidney.... more...

Description from OMIM:47 304800,125800

GeneReviews summary for ndi

Aliases & Classifications for Nephrogenic Diabetes Insipidus

Sources:
8Disease Ontology, 9diseasecard, 19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Characteristics (Orphanet epidemiological data):

49
nephrogenic diabetes insipidus:
Inheritance: Autosomal dominant,Autosomal recessive,X-linked recessive; Prevalence: 1-9/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

nephrogenic diabetes insipidus 8 19 43 21 10 49 61
diabetes insipidus nephrogenic x-linked 43 20 22
diabetes insipidus, nephrogenic 9 21 47
diabetes insipidus nephrogenic 43 20 45
congenital nephrogenic diabetes insipidus 21 61
vasopressin-resistant diabetes insipidus 43 21
nephrogenic diabetes insipidus, type i 61
diabetes insipidus nephrogenic type 1 43
adh-resistant diabetes insipidus 21
adh resistant diabetes insipidus 43
central diabetes insipidus 61
diabetes insipidus renalis 21
ndi 21


External Ids:

Disease Ontology8 DOID:12387
ICD9CM27 588.1
NCIt40 C84919
MeSH35 D018500
MESH via Orphanet36 D018500
ICD10 via Orphanet26 N25.1
SNOMED-CT via Orphanet58 111395007
UMLS via Orphanet62 C0162283
ICD1025 N25.1

Related Diseases for Nephrogenic Diabetes Insipidus

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Nephrogenic Diabetes Insipidus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus32.3AQP2, AQP6, AVP, AVPR2
2neurogenic diabetes insipidus30.8AVPR2, AVP, AQP2
3adult syndrome30.5DNAJA2
4l1 syndrome30.3L1CAM
5polyhydramnios30.3BSND, SLC12A1, AQP1
6n syndrome10.9
7nephrogenic diabetes insipidus - intracranial calcification10.8
8nephrogenic diabetes insipidus, autosomal10.8
9hydronephrosis10.7
10fanconi syndrome10.7
11renal tubular acidosis10.7
12congenital central diabetes insipidus10.6
13panhypopituitarism10.6
14acute leukemia10.6
15germinoma10.6
16lymphocytic hypophysitis10.5
17nephrocalcinosis10.5
18neurohypophyseal diabetes insipidus10.5
19acquired central diabetes insipidus10.5
20rickets10.5
21renal tubular acidosis, distal10.5
22nephritis10.5
23congenital hydronephrosis10.5
24congenital toxoplasmosis10.5
25toxoplasmosis10.5
26sheehan syndrome10.4
27brain injury10.4
28neurosarcoidosis10.4
29traumatic brain injury10.4
30ureteral obstruction10.4
31bladder neck obstruction10.4
32acquired immunodeficiency syndrome10.4
33hypervitaminosis d10.4
34diabetes insipidus nephrogenic mental retardation and intracerebral calcification10.4
35acute myeloid leukemia10.3
36pituitary apoplexy10.3
37multifocal fibrosclerosis10.3
38werdnig-hoffmann disease10.2
39primary hyperparathyroidism10.2
40proteus syndrome10.2
41hypoparathyroidism10.2
42hemochromatosis10.2
43cystinosis10.2
44central pontine myelinolysis10.2
45pseudopseudohypoparathyroidism10.2
46secondary syphilis10.2
47cauda equina syndrome10.2
48hypokalemic periodic paralysis10.2
49neuroleptic malignant syndrome10.2
50fabry disease10.2

Graphical network of the top 20 diseases related to Nephrogenic Diabetes Insipidus:



Diseases related to nephrogenic diabetes insipidus

Clinical Features for Nephrogenic Diabetes Insipidus

Sources:
47OMIM
See all sources

Clinical features from OMIM:

304800,125800

Clinical synopsis from OMIM:

125800

Drugs & Therapeutics for Nephrogenic Diabetes Insipidus

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Nephrogenic Diabetes Insipidus

Drug clinical trials:

Search ClinicalTrials for Nephrogenic Diabetes Insipidus

Search NIH Clinical Center for Nephrogenic Diabetes Insipidus

Search CenterWatch for Nephrogenic Diabetes Insipidus

Genetic Tests for Nephrogenic Diabetes Insipidus

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Nephrogenic Diabetes Insipidus:

id Genetic test Affiliating Genes
1 Nephrogenic Diabetes Insipidus20 AVPR2
2 Nephrogenic Diabetes Insipidus, X-linked20 22 AVPR2

Anatomical Context for Nephrogenic Diabetes Insipidus

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Nephrogenic Diabetes Insipidus:

33
Brain, Kidney, Lung, Bone marrow, Small intestine, Prostate, B cells, Fetal brain, Fetal lung

Animal Models for Nephrogenic Diabetes Insipidus or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Nephrogenic Diabetes Insipidus

Sources:
51PubMed
See all sources

Articles related to Nephrogenic Diabetes Insipidus:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
Phenotype variability in nephrogenic diabetes insipidus due to p.D85N mutation in the arginine vasopressin receptor 2 gene. (23600372)
2013
2
Identification and characterization of a novel X-linked AVPR2 mutation causing partial nephrogenic diabetes insipidus: a case report and review of the literature. (22386940)
2012
3
ARC syndrome with complex renal problems: nephrocalcinosis, proximal and hyperkalemic distal RTA and nephrogenic diabetes insipidus. (22805396)
2012
4
Two new large deletions of the AVPR2 gene causing nephrogenic diabetes insipidus and a review of previously published deletions. (22879391)
2012
5
A novel contiguous gene deletion of AVPR2 and ARHGAP4 genes in male dizygotic twins with nephrogenic diabetes insipidus and intellectual disability. (22965914)
2012
6
Nephrogenic diabetes insipidus : Old deletion, new effect. A case report of a family from Greece. (24391420)
2011
7
Interstitial nephritis and nephrogenic diabetes insipidus in a patient treated with pemetrexed. (20722569)
2010
8
Skewed X-chromosome inactivation causing diagnostic misinterpretation in congenital nephrogenic diabetes insipidus. (20459358)
2010
9
Hypokalemic periodic paralysis associated with thyrotoxicosis, renal tubular acidosis and nephrogenic diabetes insipidus. (20150720)
2010
10
Lithium-induced nephrogenic diabetes insipidus: new clinical and experimental findings. (21170888)
2010
11
Amiloride blocks lithium entry through the sodium channel thereby attenuating the resultant nephrogenic diabetes insipidus. (19367330)
2009
12
Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus. (19170711)
2009
13
Nephrogenic diabetes insipidus]. (17081961)
2006
14
Urological complications of congenital nephrogenic diabetes insipidus--long-term follow-up of one patient. (17111080)
2006
15
Deletion of the V2 vasopressin receptor gene in two Chinese patients with nephrogenic diabetes insipidus. (17101063)
2006
16
Severe bladder dysfunction in a family with ADH receptor gene mutation responsible for X-linked nephrogenic diabetes insipidus. (15496575)
2004
17
Diffusion in the endoplasmic reticulum of an aquaporin-2 mutant causing human nephrogenic diabetes insipidus. (11297561)
2001
18
Vasopressin receptor mutations and nephrogenic diabetes insipidus. (10714359)
1999
19
Aquaporin-2 water channel mutations and nephrogenic diabetes insipidus: new variations on a theme. (10069656)
1999
20
Clinical presentation and follow-up of 30 patients with congenital nephrogenic diabetes insipidus. (10477148)
1999
21
Mutational analyses of AVPR2 gene in three Japanese families with X- linked nephrogenic diabetes insipidus: two recurrent mutations, R137H and deltaV278, caused by the hypermutability at CpG dinucleotides. (9452109)
1998
22
Ifosfamide-induced renal Fanconi syndrome with associated nephrogenic diabetes insipidus in an adult patient. (9641191)
1998
23
Nephrogenic diabetes insipidus and tethered cord syndrome with a lipoma of the cauda equina. (9533561)
1998
24
Congenital nephrogenic diabetes insipidus. (9402099)
1997
25
Nephrogenic diabetes insipidus induced by lobenzarit disodium treatment in patients with rheumatoid arthritis. (8680099)
1996
26
Molecular analysis of X-linked nephrogenic diabetes insipidus. (8766931)
1996
27
Hereditary nephrogenic diabetes insipidus]. (7640759)
1995
28
Nephrogenic diabetes insipidus: an X chromosome-linked dominant inheritance pattern with a vasopressin type 2 receptor gene that is structurally normal. (8078903)
1994
29
Novel mutations in the V2 vasopressin receptor gene in two pedigrees with congenital nephrogenic diabetes insipidus. (8045948)
1994
30
Nephrogenic diabetes insipidus. A V2 vasopressin receptor unable to stimulate adenylyl cyclase. (8514744)
1993
31
Nephrogenic diabetes insipidus in sibling colts. (8501698)
1993
32
A Null mutation in the vasopressin V2 receptor gene (AVPR2) associated with nephrogenic diabetes insipidus in the Hopewell kindred. (8401502)
1993
33
Familial nephrogenic diabetes insipidus: report of two families. (1358355)
1992
34
A low affinity vasopressin V2-receptor in inherited nephrogenic diabetes insipidus. (1387165)
1992
35
Therapy for hereditary nephrogenic diabetes insipidus. (1861225)
1991
36
Linkage analyses in families with nephrogenic diabetes insipidus. (2569742)
1989
37
Hemodynamic and coagulation responses to 1-desamino[8-D-arginine] vasopressin in patients with congenital nephrogenic diabetes insipidus. (2965301)
1988
38
Two distinct pathophysiological mechanisms in congenital nephrogenic diabetes insipidus. (3131381)
1988
39
Extensive glomerular immaturity associated with renal tubular acidosis, nephrogenic diabetes insipidus and nephrocalcinosis. (3609098)
1987
40
Transient nephrogenic diabetes insipidus associated with pregnancy. (4083316)
1985
41
Altered catecholamine innervation of the supraoptic nucleus in the nephrogenic diabetes insipidus mouse. (3903537)
1985
42
Nephrogenic diabetes insipidus associated with Dyazide (triamterene-hydrochlorothiazide). (6794799)
1981
43
Hyperthyroidism associated with renal tubular acidosis, nephrocalcinosis, nephrogenic diabetes insipidus and periodic paralysis. Report of a case. (7291766)
1981
44
Nephrogenic diabetes insipidus in three dogs. (7287546)
1981
45
Congenital nephrogenic diabetes insipidus with bilateral hydronephrosis: indomethacin in treatment of nephrogenic diabetes insipidus. (7314648)
1980
46
Tumor-associated nephrogenic diabetes insipidus. (7387021)
1980
47
Congenital nephrogenic diabetes insipidus. (507907)
1979
48
Congenital nephrogenic diabetes insipidus in a baby girl. (215090)
1978
49
The mechanism of urinary concentration in nephrogenic diabetes insipidus. (188007)
1977
50
The recognition of nephrogenic diabetes insipidus. A very small page from the history of medicine. (47696)
1975

Genetic Variations for Nephrogenic Diabetes Insipidus

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Nephrogenic Diabetes Insipidus:

63 (show all 108)
id Symbol AA change Variation SNP ID
1AQP2p.Gly64ArgVAR_004401
2AQP2p.Arg187CysVAR_004402
3AQP2p.Ser216ProVAR_004403
4AQP2p.Leu22ValVAR_015239
5AQP2p.Leu28ProVAR_015240
6AQP2p.Ala47ValVAR_015241
7AQP2p.Asn68SerVAR_015242
8AQP2p.Val71MetVAR_015243
9AQP2p.Thr125MetVAR_015244
10AQP2p.Thr126MetVAR_015245
11AQP2p.Ala147ThrVAR_015246
12AQP2p.Val168MetVAR_015247
13AQP2p.Gly175ArgVAR_015248
14AQP2p.Cys181TrpVAR_015249
15AQP2p.Pro185AlaVAR_015250
16AQP2p.Ala190ThrVAR_015251
17AQP2p.Trp202CysVAR_015253
18AQP2p.Glu258LysVAR_015254
19AQP2p.Pro262LeuVAR_015255
20AQP2p.Gln57ProVAR_015256rs28931580
21AQP2p.Gly100ValVAR_015257rs28929477
22AQP2p.Ala70AspVAR_062585
23AQP2p.Gly100ArgVAR_062586
24AQP2p.Gly180SerVAR_062587
25AQP2p.Arg187HisVAR_062588
26AQP2p.Arg254LeuVAR_062589
27AQP2p.Arg254GlnVAR_062590
28AVPR2p.Leu44ProVAR_003517
29AVPR2p.His80ArgVAR_003520
30AVPR2p.Val88MetVAR_003521
31AVPR2p.Arg106CysVAR_003522
32AVPR2p.Cys112ArgVAR_003523
33AVPR2p.Arg113TrpVAR_003524rs28935496
34AVPR2p.Ser126PheVAR_003525
35AVPR2p.Tyr128SerVAR_003526
36AVPR2p.Ala132AspVAR_003527
37AVPR2p.Arg137HisVAR_003528
38AVPR2p.Arg143ProVAR_003529
39AVPR2p.Trp164SerVAR_003531
40AVPR2p.Ser167LeuVAR_003532
41AVPR2p.Ser167ThrVAR_003533
42AVPR2p.Arg181CysVAR_003534
43AVPR2p.Gly185CysVAR_003535
44AVPR2p.Arg202CysVAR_003536
45AVPR2p.Arg203CysVAR_003537
46AVPR2p.Tyr205CysVAR_003538
47AVPR2p.Tyr280CysVAR_003541
48AVPR2p.Pro286LeuVAR_003543
49AVPR2p.Pro286ArgVAR_003544
50AVPR2p.Leu292ProVAR_003545
51AVPR2p.Leu309ProVAR_003546
52AVPR2p.Asn317LysVAR_003547
53AVPR2p.Trp323SerVAR_003548
54AVPR2p.Leu43ProVAR_015297
55AVPR2p.Ile46LysVAR_015298
56AVPR2p.Leu53ArgVAR_015299
57AVPR2p.Asn55AspVAR_015300
58AVPR2p.Asn55HisVAR_015301
59AVPR2p.Leu59ProVAR_015302
60AVPR2p.Leu62ProVAR_015304
61AVPR2p.Leu81PheVAR_015305
62AVPR2p.Leu83ProVAR_015306
63AVPR2p.Leu83GlnVAR_015307
64AVPR2p.Ala84AspVAR_015308
65AVPR2p.Asp85AsnVAR_015309
66AVPR2p.Gln92ArgVAR_015310
67AVPR2p.Leu94GlnVAR_015311
68AVPR2p.Pro95LeuVAR_015312
69AVPR2p.Trp99ArgVAR_015313
70AVPR2p.Arg104CysVAR_015314
71AVPR2p.Phe105ValVAR_015315
72AVPR2p.Gly107GluVAR_015316
73AVPR2p.Cys112TyrVAR_015317
74AVPR2p.Gly122ArgVAR_015318
75AVPR2p.Met123LysVAR_015319
76AVPR2p.Ser127PheVAR_015320
77AVPR2p.Ile130PheVAR_015321
78AVPR2p.Leu135ProVAR_015322
79AVPR2p.Ala163ProVAR_015324
80AVPR2p.Pro173SerVAR_015325
81AVPR2p.Gln174LeuVAR_015326
82AVPR2p.Asp191GlyVAR_015327
83AVPR2p.Gly201AspVAR_015328
84AVPR2p.Thr204AsnVAR_015329
85AVPR2p.Val206AspVAR_015330
86AVPR2p.Thr207AsnVAR_015331
87AVPR2p.Ile209PheVAR_015332
88AVPR2p.Phe214SerVAR_015333
89AVPR2p.Pro217ThrVAR_015335
90AVPR2p.Leu219ProVAR_015336
91AVPR2p.Leu219ArgVAR_015337
92AVPR2p.Met272LysVAR_015339
93AVPR2p.Val277AlaVAR_015340
94AVPR2p.Leu282ProVAR_015341
95AVPR2p.Pro286SerVAR_015342
96AVPR2p.Phe287LeuVAR_015343
97AVPR2p.Leu289ProVAR_015344
98AVPR2p.Ala294ProVAR_015345
99AVPR2p.Leu309ArgVAR_015346
100AVPR2p.Ser315ArgVAR_015347
101AVPR2p.Cys319ArgVAR_015349
102AVPR2p.Asn321AspVAR_015350
103AVPR2p.Asn321LysVAR_015351
104AVPR2p.Asn321TyrVAR_015352
105AVPR2p.Pro322HisVAR_015353
106AVPR2p.Pro322SerVAR_015354
107AVPR2p.Trp323ArgVAR_015355
108AVPR2p.Gly122AspVAR_062591

Expression for genes affiliated with Nephrogenic Diabetes Insipidus

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Nephrogenic Diabetes Insipidus

Search GEO for disease gene expression data for Nephrogenic Diabetes Insipidus.

Pathways for genes affiliated with Nephrogenic Diabetes Insipidus

Sources:
30KEGG, 54Reactome, 50PharmGKB, 52QIAGEN
See all sources

Compounds for genes affiliated with Nephrogenic Diabetes Insipidus

Sources:
29IUPHAR, 60Tocris Bioscience, 45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Nephrogenic Diabetes Insipidus according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1d(ch2)5[tyr(et)2,val4,des-gly9]avp2910.6AVPR1B, AVPR2
2[phaa1,d-tyr(et)2,val4,lys6,tyr-nh28,des-gly9]avp2910.6AVPR2, AVPR1B
3d(ch2)5[d-ile2,ile4,ala-nh29]avp2910.6AVPR2, AVPR1B
4d(ch2)5[d-ile2,ile4,ala-nh2]avp2910.6AVPR2, AVPR1B
5[tbaa1,d-tyr(et)2,val4,lys6,arg-nh28,des-gly9]avp2910.6AVPR2, AVPR1B
6ym 4712910.6AVPR1B, AVPR2
7sr 121463a2910.6AVPR2, AVPR1B
8d(ch2)5[tyr(me)2,thr4]ovt2910.6AVPR2, AVPR1B
9ym 2182910.6AVPR2, AVPR1B
10opc-312602910.6AVPR2, AVPR1B
11d[d-pal2]avp2910.6AVPR2, AVPR1B
12oh-lva2910.6AVPR1B, AVPR2
13dvdavp2910.6AVPR2, AVPR1B
14[val4]avp2910.6AVPR2, AVPR1B
15d[d-phe2]avp2910.6AVPR2, AVPR1B
16d[leu4,lys8]-vp6010.5AVPR2, AVP, AVPR1B
17(d(ch2)51,tyr(me)2,arg8)-vasopressin6010.5AVPR2, AVP, AVPR1B
18[arg8]-vasopressin6010.5AVPR2, AVP, AVPR1B
19lvp2910.5AVPR1B, AVPR2
20sr 4905960 2911.5AVPR1B, AVP, AVPR2
21hg2+4510.5MIP, AQP1
22[phaa1,d-tyr(et)2,lys6,des-gly9]avp2910.5AVPR2, AVPR1B
23hgcl24510.5MIP, AQP1, AQP2
24[phaa1,d-tyr2,val4,arg6,arg-nh29]avp2910.5AVPR2, AVPR1B
25mercury4510.5AQP2, AQP1, MIP
26[phaa1,d-tyr(me)2,arg6,tyr-nh29]avp2910.5AVPR2, AVPR1B
27d[pen1,tyr(me)2]avp2910.5AVPR2, AVPR1B
28avt2910.5AVPR2, AVPR1B
29d(ch2)5[tyr(me)2]avp2910.5AVPR1B, AVPR2
30[3h]ot (human, mouse, rat)2910.4AVPR1B, AVPR2
31d(ch2)5[tyr(me)2,thr4,phe(3i,4n3)-nh29]ovt2910.4AVPR1B, AVPR2
32desmopressin45 60 29 1113.4AVPR2, AVP, AVPR1B, AQP2
33d(ch2)5[tyr(me)2,thr4,tyr-nh29]ovt2910.4AVPR1B, AVPR2
34d[leu4]avp2910.4AVPR2, AVPR1B
35urea45 11 2412.4MIP, SLC12A1, AQP1, AQP2
36d[cha4]avp2910.3AVPR1B, AVPR2
37ammonium4510.3MIP, SLC12A1, AQP1, AQP8
38[3h]avp2910.3AVPR1B, AVPR2
39davp2910.2AVPR1B, AVPR2
40atosiban29 4511.2AVPR1B, AVPR2
41glycerol45 11 2412.1MIP, AQP6, AQP1, AQP2, AQP8
42nacl4510.1BSND, MIP, CLCNKA, SLC12A1, AQP1, AQP2
43ssr1494152910.1AVPR1B, AVPR2
44potassium45 11 2412.0BSND, MIP, CLCNKA, AVPR2, SLC12A1, AQP1
45hg2+2910.0AQP10, MIP, AQP6, AQP1, AQP2, AQP8
46chloride459.9BSND, MIP, CLCNKA, AVPR2, AVP, SLC12A1
47sodium45 2410.9BSND, MIP, CLCNKA, AVPR2, AVP, SLC12A1
48arginine459.8ARHGAP4, ARHGAP1, MIP, AVPR2, AVP, AVPR1B
49furosemide45 50 60 29 11 2414.8AQP2, SLC12A1, BSND
50calcium45 50 11 2412.5MRGPRX1, BSND, MIP, CLCNKA, AVPR2, AVP

GO Terms for genes affiliated with Nephrogenic Diabetes Insipidus

Sources:
16Gene Ontology
See all sources

Cellular components related to Nephrogenic Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:01632310.1AQP2, AQP1, BSND
2intracellular canaliculusGO:0466919.9AQP8, MIP
3integral to plasma membraneGO:0058879.2BSND, MIP, CLCNKA, AVPR2, AVPR1B, AQP6
4plasma membraneGO:0058868.3AQP11, L1CAM, MRGPRX1, BSND, ARHGAP1, MIP

Biological processes related to Nephrogenic Diabetes Insipidus according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1renal water transportGO:00309710.4AQP2, AQP1
2cellular response to mercury ionGO:07128810.4AQP1, AQP2
3multicellular organismal water homeostasisGO:05089110.4AVP, AQP1
4canalicular bile acid transportGO:01572210.3AQP8, MIP
5cellular response to copper ionGO:07128010.3AQP1, AQP2
6positive regulation of systemic arterial blood pressureGO:00308410.3AVP, AVPR2
7glycerol transportGO:01579310.3AQP11, AQP2, AQP1
8excretionGO:00758810.2CLCNKA, AVPR2, AQP6, AQP2
9cell volume homeostasisGO:00688410.1AQP2, AQP1
10ion transmembrane transportGO:03422010.1SLC12A1, CLCNKA, BSND
11transportGO:0068109.5CLCNKA, SLC12A1, AQP6, AQP8
12water transportGO:0068339.4AQP11, AQP10, AQP8, AQP2, AQP1, AQP6
13transmembrane transportGO:0550859.0AQP11, BSND, MIP, AQP10, AQP8, AQP2

Molecular functions related to Nephrogenic Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycerol transmembrane transporter activityGO:01516810.3AQP2, AQP1
2Rho GTPase activator activityGO:00510010.2ARHGAP1, ARHGAP4
3water transmembrane transporter activityGO:00537210.1AQP2, AQP1
4water channel activityGO:01525010.0AQP8, AQP1, AQP6, MIP
5vasopressin receptor activityGO:0050009.9AVPR1B, AVPR2
6transporter activityGO:0052159.8MIP, AQP12A, AQP10, AQP11

Products for genes affiliated with Nephrogenic Diabetes Insipidus

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nephrogenic Diabetes Insipidus

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet