NDI
MCID: NPH007
MIFTS: 77

Nephrogenic Diabetes Insipidus (NDI) malady

Nephrological diseases category

Summaries for Nephrogenic Diabetes Insipidus

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42NIH Rare Diseases, 21Genetics Home Reference, 63Wikipedia, 46OMIM, 19GeneReviews, 32MalaCards
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NIH Rare Diseases:42 Nephrogenic diabetes insipidus is a disorder in which a defect in the small tubes (tubules) in the kidneys causes a person to pass a large amount of urine. nephrogenic diabetes insipidus occurs when the kidney tubules, which allow water to be removed from the body or reabsorbed, do not respond to a chemical in the body called antidiuretic hormone (adh) or vasopressin. adh normally tells the kidneys to make the urine more concentrated. as a result of the defect, the kidneys release an excessive amount of water into the urine, producing a large quantity of very dilute urine.nephrogenic diabetes insipidus can be either acquired or hereditary. the acquired form is brought on by certain drugs and chronic diseases and can occur at any time during life. the hereditary form is caused by genetic mutations, and its signs and symptoms usually become apparent within the first few months of life. last updated: 7/31/2011

MalaCards: Nephrogenic Diabetes Insipidus, also known as diabetes insipidus nephrogenic x-linked, is related to diabetes insipidus and neurogenic diabetes insipidus. An important gene associated with Nephrogenic Diabetes Insipidus is AVPR2 (arginine vasopressin receptor 2), and among its related pathways are Vasopressin-regulated water reabsorption and Vasopressin-like receptors. The compounds [phaa1,d-tyr(et)2,lys6,des-gly9]avp and d(ch2)5[d-ile2,ile4,ala-nh2]avp have been mentioned in the context of this disorder. Affiliated tissues include kidney, testes and brain, and related mouse phenotypes are behavior/neurological and renal/urinary system.

Genetics Home Reference:21 Nephrogenic diabetes insipidus is a disorder of water balance. The body normally balances fluid intake with the excretion of fluid in urine. However, people with nephrogenic diabetes insipidus produce too much urine (polyuria), which causes them to be excessively thirsty (polydipsia). Affected individuals can quickly become dehydrated if they do not drink enough water, especially in hot weather or when they are sick.

Wikipedia:63 Nephrogenic diabetes insipidus is a form of diabetes insipidus primarily due to pathology of the kidney.... more...

Description from OMIM:46 304800,125800

GeneReviews summary for ndi

Aliases & Classifications for Nephrogenic Diabetes Insipidus

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8Disease Ontology, 19GeneReviews, 42NIH Rare Diseases, 21Genetics Home Reference, 10DISEASES, 48Orphanet, 60UMLS, 9diseasecard, 46OMIM, 20GeneTests, 44Novoseek, 22GTR, 27ICD9CM, 56SNOMED-CT, 39NCIt, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Characteristics (Orphanet epidemiological data):

48
nephrogenic diabetes insipidus:
Inheritance: Autosomal dominant,Autosomal recessive,X-linked recessive; Prevalence: 1-9/1000000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

nephrogenic diabetes insipidus 8 19 42 21 10 48 60
diabetes insipidus nephrogenic x-linked 42 20 22
diabetes insipidus, nephrogenic 9 21 46
diabetes insipidus nephrogenic 42 20 44
congenital nephrogenic diabetes insipidus 21 60
vasopressin-resistant diabetes insipidus 42 21
nephrogenic diabetes insipidus, type i 60
diabetes insipidus nephrogenic type 1 42
adh-resistant diabetes insipidus 21
adh resistant diabetes insipidus 42
central diabetes insipidus 60
diabetes insipidus renalis 21
ndi 21


External Ids:

Disease Ontology8 DOID:12387
ICD9CM27 588.1
NCIt39 C84919
MeSH34 D018500
MESH via Orphanet35 D018500
ICD10 via Orphanet26 N25.1
SNOMED-CT via Orphanet57 111395007
UMLS via Orphanet61 C0162283
ICD1025 N25.1

Related Diseases for Nephrogenic Diabetes Insipidus

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17GeneCards, 18GeneDecks
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Diseases related to Nephrogenic Diabetes Insipidus via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1diabetes insipidus32.3AVP, AQP2, AQP6, AVPR2
2neurogenic diabetes insipidus30.7AVP, AQP2, AVPR2
3adult syndrome30.5DNAJA2
4hydrocephalus30.5L1CAM, AQP1
5l1 syndrome30.3L1CAM
6polyhydramnios30.3SLC12A1, BSND, AQP1
7hydronephrosis10.7
8renal tubular acidosis10.7
9hypopituitarism10.6
10leukemia10.6
11fanconi syndrome10.6
12panhypopituitarism10.6
13acute leukemia10.6
14neurohypophyseal diabetes insipidus10.5
15nephrocalcinosis10.5
16hyperparathyroidism10.5
17nephrogenic diabetes insipidus, autosomal10.5
18histiocytosis10.5
19langerhans-cell histiocytosis10.5
20rickets10.5
21nephrogenic diabetes insipidus - intracranial calcification10.5
22congenital toxoplasmosis10.4
23toxoplasmosis10.4
24encephalitis10.4
25myeloid leukemia10.4
26ureteral obstruction10.4
27bladder neck obstruction10.4
28acquired immunodeficiency syndrome10.4
29hypervitaminosis d10.4
30arc syndrome10.4
31interstitial nephritis10.4
32diabetes insipidus nephrogenic mental retardation and intracerebral calcification10.4
33acute myeloid leukemia10.3
34pituitary apoplexy10.3
35diabetes mellitus10.3
36hypogonadism10.3
37sarcoidosis10.3
38acquired central diabetes insipidus10.3
39congenital central diabetes insipidus10.3
40diabetic nephropathy10.2
41werdnig-hoffmann disease10.2
42urethritis10.2
43primary hyperparathyroidism10.2
44proteus syndrome10.2
45cerebritis10.2
46hypoparathyroidism10.2
47hemochromatosis10.2
48cystinosis10.2
49neuronitis10.2
50central pontine myelinolysis10.2

Graphical network of the top 20 diseases related to Nephrogenic Diabetes Insipidus:



Diseases related to nephrogenic diabetes insipidus

Clinical Features for Nephrogenic Diabetes Insipidus

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46OMIM
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Clinical features from OMIM:

304800,125800

Clinical synopsis from OMIM:

125800

Drugs & Therapeutics for Nephrogenic Diabetes Insipidus

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Nephrogenic Diabetes Insipidus

Drug clinical trials:

Search ClinicalTrials for Nephrogenic Diabetes Insipidus

Search NIH Clinical Center for Nephrogenic Diabetes Insipidus

Search CenterWatch for Nephrogenic Diabetes Insipidus

Genetic Tests for Nephrogenic Diabetes Insipidus

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20GeneTests, 22GTR
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Genetic tests related to Nephrogenic Diabetes Insipidus:

id Genetic test Affiliating Genes
1 Nephrogenic Diabetes Insipidus20 AVPR2
2 Nephrogenic Diabetes Insipidus, X-Linked20 22 AVPR2

Anatomical Context for Nephrogenic Diabetes Insipidus

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32MalaCards
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MalaCards organs/tissues related to Nephrogenic Diabetes Insipidus:

32
Kidney, Testes, Brain, Bone marrow, Bone, Lung, Prostate

Animal Models for Nephrogenic Diabetes Insipidus or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nephrogenic Diabetes Insipidus:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.4BSND, AVPR2, AVP, AVPR1B, SLC12A1, AQP1
2MP:00053679.0AQP11, BSND, ARHGAP1, CLCNKA, AVPR2, AVP
3MP:00053788.9L1CAM, BSND, ARHGAP1, AVPR2, GPBAR1, SLC12A1
4MP:00053768.5AVP, AVPR2, CLCNKA, ARHGAP1, BSND, AVPR1B

Publications for Nephrogenic Diabetes Insipidus

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50PubMed
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Articles related to Nephrogenic Diabetes Insipidus:

(show top 50)    (show all 506)
idTitleAuthorsYear
1
QT interval prolongation and bradycardia in lithium-induced nephrogenic diabetes insipidus. (22592036)
2012
2
New autosomal recessive mutations in aquaporin-2 causing nephrogenic diabetes insipidus through deficient targeting display normal expression in Xenopus oocytes. (20403973)
2010
3
A novel missense mutation in the AVPR2 gene of a Japanese infant with nephrogenic diabetes insipidus. (20583549)
2010
4
Potential of nonpeptide (ant)agonists to rescue vasopressin V2 receptor mutants for the treatment of X-linked nephrogenic diabetes insipidus. (20163515)
2010
5
Salt-losing nephrogenic diabetes insipidus caused by fetal exposure to angiotensin receptor blocker. (19153776)
2009
6
Wilms tumor arising in a child with X-linked nephrogenic diabetes insipidus. (19294427)
2009
7
Identification of two novel aquaporin-2 mutations in a Thai girl with congenital nephrogenic diabetes insipidus. (18473191)
2008
8
Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus. (18216143)
2008
9
Characterization of two novel missense mutations in the AQP2 gene causing nephrogenic diabetes insipidus. (17192724)
2007
10
Mouse models for congenital nephrogenic diabetes insipidus: what can we learn from them? (17277344)
2007
11
Nephrogenic diabetes insipidus. (16580609)
2006
12
Nephrogenic diabetes insipidus caused by mutation of Tyr205: a key residue of V2 vasopressin receptor function. (15841479)
2005
13
Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms. (16024729)
2005
14
A novel mechanism in recessive nephrogenic diabetes insipidus: wild- type aquaporin-2 rescues the apical membrane expression of intracellularly retained AQP2-P262L. (15509592)
2004
15
Molecular pathogenesis of nephrogenic diabetes insipidus. (14586738)
2003
16
Successful treatment of partial nephrogenic diabetes insipidus with thiazide and desmopressin. (12784095)
2003
17
Treating nephrogenic diabetes insipidus: a case study. (12042694)
2002
18
Nocturnal enuresis in patients with nephrogenic diabetes insipidus. (12241956)
2002
19
Lithium-induced nephrogenic diabetes insipidus. (11246113)
2001
20
Molecular and cellular defects in nephrogenic diabetes insipidus. (11793119)
2001
21
Nephrogenic diabetes insipidus persisting 57 months after cessation of lithium carbonate therapy: report of a case and review of the literature. (11242610)
2000
22
Aldose reductase-deficient mice develop nephrogenic diabetes insipidus. (10913167)
2000
23
Compound deletion of the rhoGAP C1 and V2 vasopressin receptor genes in a patient with nephrogenic diabetes insipidus. (10425039)
1999
24
Effect of DDAVP on nocturnal enuresis in a patient with nephrogenic diabetes insipidus. (10373137)
1999
25
Autosomal recessive nephrogenic diabetes insipidus caused by an aquaporin-2 mutation. (9024277)
1997
26
Six novel mutations in the vasopressin V2 receptor gene causing nephrogenic diabetes insipidus. (9127330)
1997
27
Urinary content of aquaporin 1 and 2 in nephrogenic diabetes insipidus. (8793791)
1996
28
Functional rescue of mutant V2 vasopressin receptors causing nephrogenic diabetes insipidus by a co-expressed receptor polypeptide. (8635461)
1996
29
Vasopressin V2 receptor mutants that cause X-linked nephrogenic diabetes insipidus: analysis of expression, processing, and function. (8863826)
1996
30
Transient central diabetes insipidus in the setting of underlying chronic nephrogenic diabetes insipidus associated with lithium use. (8739289)
1996
31
Two vasopressin type 2 receptor gene mutations R143P and delta V278 in patients with nephrogenic diabetes insipidus impair ligand binding of the receptor. (7598729)
1995
32
Expression studies of two vasopressin V2 receptor gene mutations, R202C and 804insG, in nephrogenic diabetes insipidus. (7564126)
1995
33
Clinical phenotype of nephrogenic diabetes insipidus in females heterozygous for a vasopressin type 2 receptor mutation. (7607658)
1995
34
Nephrogenic diabetes insipidus following high dose epirubicin chemotherapy for metastatic soft tissue sarcoma. (7695964)
1995
35
Molecular characterization of nephrogenic diabetes insipidus. (18407239)
1994
36
Index of suspicion. Case 2. Nephrogenic diabetes insipidus. (8036197)
1994
37
Type 2 vasopressin receptor gene, the gene responsible nephrogenic diabetes insipidus, maps to Xq28 close to the LICAM gene. (8323561)
1993
38
Nephrogenic diabetes insipidus: clinical symptoms, pathogenesis, genetics and treatment. (1457333)
1992
39
Mutations in the V2 vasopressin receptor gene are associated with X- linked nephrogenic diabetes insipidus. (1303257)
1992
40
Primary hyperparathyroidism and coexisting nephrogenic diabetes insipidus: rapid postoperative correction. (1882251)
1991
41
Derivatives of somatic cell hybrids which carry the human gene locus for nephrogenic diabetes insipidus (NDI) express functional vasopressin renal V2-type receptors. (2168411)
1990
42
Expression of a metallothionein-vasopressin fusion gene in transgenic mice produces hypervasopressinemia and manifestations of nephrogenic diabetes insipidus. (3269675)
1988
43
Nephrogenic diabetes insipidus, cystinosis, and vitamin D. (3389874)
1988
44
Hereditary nephrogenic diabetes insipidus type-2. (3149133)
1988
45
A case with persistent nephrogenic diabetes insipidus following parathyroidectomy for hyperparathyroidism. (3225402)
1988
46
Treatment of nephrogenic diabetes insipidus. (3773945)
1986
47
Indomethacin for nephrogenic diabetes insipidus in a four-week-old infant. (3956132)
1986
48
Water intoxication associated with nephrogenic diabetes insipidus secondary to lithium: case report. (3928603)
1985
49
Persistent lithium-induced nephrogenic diabetes insipidus. (696918)
1978
50
Nephrogenic diabetes insipidus with fluorosis. (4414789)
1974

Genetic Variations for Nephrogenic Diabetes Insipidus

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Nephrogenic Diabetes Insipidus:

62 (show all 108)
id Symbol AA change Variation ID SNP ID
1AQP2p.Gly64ArgVAR_004401
2AQP2p.Arg187CysVAR_004402
3AQP2p.Ser216ProVAR_004403
4AQP2p.Leu22ValVAR_015239
5AQP2p.Leu28ProVAR_015240
6AQP2p.Ala47ValVAR_015241
7AQP2p.Asn68SerVAR_015242
8AQP2p.Val71MetVAR_015243
9AQP2p.Thr125MetVAR_015244
10AQP2p.Thr126MetVAR_015245
11AQP2p.Ala147ThrVAR_015246
12AQP2p.Val168MetVAR_015247
13AQP2p.Gly175ArgVAR_015248
14AQP2p.Cys181TrpVAR_015249
15AQP2p.Pro185AlaVAR_015250
16AQP2p.Ala190ThrVAR_015251
17AQP2p.Trp202CysVAR_015253
18AQP2p.Glu258LysVAR_015254
19AQP2p.Pro262LeuVAR_015255
20AQP2p.Gln57ProVAR_015256rs28931580
21AQP2p.Gly100ValVAR_015257rs28929477
22AQP2p.Ala70AspVAR_062585
23AQP2p.Gly100ArgVAR_062586
24AQP2p.Gly180SerVAR_062587
25AQP2p.Arg187HisVAR_062588
26AQP2p.Arg254LeuVAR_062589
27AQP2p.Arg254GlnVAR_062590
28AVPR2p.Leu44ProVAR_003517
29AVPR2p.His80ArgVAR_003520
30AVPR2p.Val88MetVAR_003521
31AVPR2p.Arg106CysVAR_003522
32AVPR2p.Cys112ArgVAR_003523
33AVPR2p.Arg113TrpVAR_003524rs28935496
34AVPR2p.Ser126PheVAR_003525
35AVPR2p.Tyr128SerVAR_003526
36AVPR2p.Ala132AspVAR_003527
37AVPR2p.Arg137HisVAR_003528
38AVPR2p.Arg143ProVAR_003529
39AVPR2p.Trp164SerVAR_003531
40AVPR2p.Ser167LeuVAR_003532
41AVPR2p.Ser167ThrVAR_003533
42AVPR2p.Arg181CysVAR_003534
43AVPR2p.Gly185CysVAR_003535
44AVPR2p.Arg202CysVAR_003536
45AVPR2p.Arg203CysVAR_003537
46AVPR2p.Tyr205CysVAR_003538
47AVPR2p.Tyr280CysVAR_003541
48AVPR2p.Pro286LeuVAR_003543
49AVPR2p.Pro286ArgVAR_003544
50AVPR2p.Leu292ProVAR_003545
51AVPR2p.Leu309ProVAR_003546
52AVPR2p.Asn317LysVAR_003547
53AVPR2p.Trp323SerVAR_003548
54AVPR2p.Leu43ProVAR_015297
55AVPR2p.Ile46LysVAR_015298
56AVPR2p.Leu53ArgVAR_015299
57AVPR2p.Asn55AspVAR_015300
58AVPR2p.Asn55HisVAR_015301
59AVPR2p.Leu59ProVAR_015302
60AVPR2p.Leu62ProVAR_015304
61AVPR2p.Leu81PheVAR_015305
62AVPR2p.Leu83ProVAR_015306
63AVPR2p.Leu83GlnVAR_015307
64AVPR2p.Ala84AspVAR_015308
65AVPR2p.Asp85AsnVAR_015309
66AVPR2p.Gln92ArgVAR_015310
67AVPR2p.Leu94GlnVAR_015311
68AVPR2p.Pro95LeuVAR_015312
69AVPR2p.Trp99ArgVAR_015313
70AVPR2p.Arg104CysVAR_015314
71AVPR2p.Phe105ValVAR_015315
72AVPR2p.Gly107GluVAR_015316
73AVPR2p.Cys112TyrVAR_015317
74AVPR2p.Gly122ArgVAR_015318
75AVPR2p.Met123LysVAR_015319
76AVPR2p.Ser127PheVAR_015320
77AVPR2p.Ile130PheVAR_015321
78AVPR2p.Leu135ProVAR_015322
79AVPR2p.Ala163ProVAR_015324
80AVPR2p.Pro173SerVAR_015325
81AVPR2p.Gln174LeuVAR_015326
82AVPR2p.Asp191GlyVAR_015327
83AVPR2p.Gly201AspVAR_015328
84AVPR2p.Thr204AsnVAR_015329
85AVPR2p.Val206AspVAR_015330
86AVPR2p.Thr207AsnVAR_015331
87AVPR2p.Ile209PheVAR_015332
88AVPR2p.Phe214SerVAR_015333
89AVPR2p.Pro217ThrVAR_015335
90AVPR2p.Leu219ProVAR_015336
91AVPR2p.Leu219ArgVAR_015337
92AVPR2p.Met272LysVAR_015339
93AVPR2p.Val277AlaVAR_015340
94AVPR2p.Leu282ProVAR_015341
95AVPR2p.Pro286SerVAR_015342
96AVPR2p.Phe287LeuVAR_015343
97AVPR2p.Leu289ProVAR_015344
98AVPR2p.Ala294ProVAR_015345
99AVPR2p.Leu309ArgVAR_015346
100AVPR2p.Ser315ArgVAR_015347
101AVPR2p.Cys319ArgVAR_015349
102AVPR2p.Asn321AspVAR_015350
103AVPR2p.Asn321LysVAR_015351
104AVPR2p.Asn321TyrVAR_015352
105AVPR2p.Pro322HisVAR_015353
106AVPR2p.Pro322SerVAR_015354
107AVPR2p.Trp323ArgVAR_015355
108AVPR2p.Gly122AspVAR_062591

Expression for genes affiliated with Nephrogenic Diabetes Insipidus

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephrogenic Diabetes Insipidus

Search GEO for disease gene expression data for Nephrogenic Diabetes Insipidus.

Pathways for genes affiliated with Nephrogenic Diabetes Insipidus

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Sources:
29KEGG, 53Reactome, 49PharmGKB, 51QIAGEN
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Compounds for genes affiliated with Nephrogenic Diabetes Insipidus

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Sources:
28IUPHAR, 59Tocris Bioscience, 44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Nephrogenic Diabetes Insipidus according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1[phaa1,d-tyr(et)2,lys6,des-gly9]avp2810.6AVPR1B, AVPR2
2d(ch2)5[d-ile2,ile4,ala-nh2]avp2810.6AVPR2, AVPR1B
3[tbaa1,d-tyr(et)2,val4,lys6,arg-nh28,des-gly9]avp2810.6AVPR2, AVPR1B
4d[d-pal2]avp2810.6AVPR2, AVPR1B
5[phaa1,d-tyr(me)2,arg6,tyr-nh29]avp2810.6AVPR1B, AVPR2
6[phaa1,d-tyr2,val4,arg6,arg-nh29]avp2810.6AVPR1B, AVPR2
7d(ch2)5[d-ile2,ile4,ala-nh29]avp2810.6AVPR1B, AVPR2
8sr 121463a2810.6AVPR1B, AVPR2
9d(ch2)5[tyr(me)2,thr4]ovt2810.6AVPR2, AVPR1B
10ym 2182810.6AVPR2, AVPR1B
11opc-312602810.6AVPR2, AVPR1B
12ym 4712810.6AVPR2, AVPR1B
13d(ch2)5[tyr(et)2,val4,des-gly9]avp2810.6AVPR2, AVPR1B
14[phaa1,d-tyr(et)2,val4,lys6,tyr-nh28,des-gly9]avp2810.6AVPR2, AVPR1B
15d[d-phe2]avp2810.6AVPR1B, AVPR2
16[arg8]-vasopressin5910.5AVPR1B, AVP, AVPR2
17[val4]avp2810.5AVPR1B, AVPR2
18(d(ch2)51,tyr(me)2,arg8)-vasopressin5910.5AVPR1B, AVP, AVPR2
19d[leu4,lys8]-vp5910.5AVP, AVPR1B, AVPR2
20sr 4905959 2811.5AVPR1B, AVP, AVPR2
21dvdavp2810.5AVPR1B, AVPR2
22hg2+4410.5MIP, AQP1
23hgcl24410.5AQP1, AQP2, MIP
24oh-lva2810.5AVPR1B, AVPR2
25mercury4410.5AQP2, MIP, AQP1
26lvp2810.5AVPR1B, AVPR2
27d[pen1,tyr(me)2]avp2810.5AVPR2, AVPR1B
28d(ch2)5[tyr(me)2,thr4,tyr-nh29]ovt2810.5AVPR1B, AVPR2
29d(ch2)5[tyr(me)2,thr4,phe(3i,4n3)-nh29]ovt2810.5AVPR2, AVPR1B
30[3h]avp2810.4AVPR1B, AVPR2
31d[cha4]avp2810.4AVPR2, AVPR1B
32desmopressin44 59 28 1113.4AVPR2, AVP, AVPR1B, AQP2
33avt2810.4AVPR1B, AVPR2
34davp2810.4AVPR1B, AVPR2
35urea44 11 2412.4MIP, SLC12A1, AQP1, AQP2
36[3h]ot (human, mouse, rat)2810.3AVPR2, AVPR1B
37ammonium4410.3MIP, SLC12A1, AQP1, AQP8
38d(ch2)5[tyr(me)2]avp2810.3AVPR1B, AVPR2
39d[leu4]avp2810.2AVPR2, AVPR1B
40atosiban28 4411.2AVPR1B, AVPR2
41glycerol44 11 2412.1MIP, AQP6, AQP8, AQP2, AQP1
42nacl4410.1CLCNKA, SLC12A1, AQP1, AQP2, BSND, MIP
43ssr1494152810.1AVPR2, AVPR1B
44potassium44 11 2412.0SLC12A1, AQP2, AQP1, BSND, MIP, CLCNKA
45hg2+2810.0AQP6, AQP10, MIP, AQP2, AQP1, AQP8
46chloride449.9AQP2, AQP1, SLC12A1, CLCNKA, AVP, MIP
47sodium44 2410.9CLCNKA, AQP2, AQP1, SLC12A1, AVP, MIP
48arginine449.8AQP1, AQP2, AVPR1B, AVP, AVPR2, MIP
49furosemide44 49 59 28 11 2414.8BSND, SLC12A1, AQP2
50calcium44 49 11 2412.5AQP2, CLCNKA, MRGPRX1, BSND, MIP, AVPR2

GO Terms for genes affiliated with Nephrogenic Diabetes Insipidus

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16Gene Ontology
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Cellular components related to Nephrogenic Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:01632310.1AQP2, AQP1, BSND
2intracellular canaliculusGO:0466919.9AQP8, MIP
3integral to plasma membraneGO:0058879.2BSND, MIP, CLCNKA, AVPR2, AVPR1B, AQP6
4plasma membraneGO:0058868.3AQP11, L1CAM, MRGPRX1, BSND, ARHGAP1, MIP

Biological processes related to Nephrogenic Diabetes Insipidus according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1renal water transportGO:00309710.4AQP2, AQP1
2cellular response to mercury ionGO:07128810.4AQP1, AQP2
3multicellular organismal water homeostasisGO:05089110.4AVP, AQP1
4canalicular bile acid transportGO:01572210.3AQP8, MIP
5cellular response to copper ionGO:07128010.3AQP1, AQP2
6positive regulation of systemic arterial blood pressureGO:00308410.3AVP, AVPR2
7glycerol transportGO:01579310.3AQP11, AQP2, AQP1
8excretionGO:00758810.2CLCNKA, AVPR2, AQP6, AQP2
9cell volume homeostasisGO:00688410.1AQP2, AQP1
10ion transmembrane transportGO:03422010.1SLC12A1, CLCNKA, BSND
11transportGO:0068109.5CLCNKA, SLC12A1, AQP6, AQP8
12water transportGO:0068339.4AQP11, AQP10, AQP8, AQP2, AQP1, AQP6
13transmembrane transportGO:0550859.0AQP11, BSND, MIP, AQP10, AQP8, AQP2

Molecular functions related to Nephrogenic Diabetes Insipidus according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycerol transmembrane transporter activityGO:01516810.3AQP2, AQP1
2Rho GTPase activator activityGO:00510010.2ARHGAP1, ARHGAP4
3water transmembrane transporter activityGO:00537210.1AQP2, AQP1
4water channel activityGO:01525010.0AQP8, AQP1, AQP6, MIP
5vasopressin receptor activityGO:0050009.9AVPR1B, AVPR2
6transporter activityGO:0052159.8MIP, AQP12A, AQP10, AQP11

Products for genes affiliated with Nephrogenic Diabetes Insipidus

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nephrogenic Diabetes Insipidus

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet