MCID: NPH018
MIFTS: 60

Nephrogenic Systemic Fibrosis malady

Rare diseases, Gastrointestinal diseases, Smell/Taste diseases, Skin diseases, Fetal diseases, Nephrological diseases categories

Summaries for Nephrogenic Systemic Fibrosis

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NIH Rare Diseases:43 Nephrogenic systemic fibrosis is a condition that affects different parts of the body, particularly the skin. symptoms of the condition may include progressive swelling and tightening of the skin, sometimes resulting in contractures, and pruritis (itching).  the skin findings are similar to those seen in patients with scleroderma.  nephrogenic systemic fibrosis was first described in 1997. being exposed to gadolinium-containing contrast agents during mri testing has been identified as a significant risk factor for development of this disease. last updated: 4/24/2013

MalaCards based summary: Nephrogenic Systemic Fibrosis, also known as nephrogenic fibrosing dermopathy, is related to kidney disease and keloids. An important gene associated with Nephrogenic Systemic Fibrosis is CCL7 (chemokine (C-C motif) ligand 7), and among its related pathways are Signaling by NODAL and Regulation of cytoplasmic and nuclear SMAD2/3 signaling. The compounds tranilast and aristolochic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and kidney, and related mouse phenotypes are digestive/alimentary and skeleton.

Wikipedia:65 Nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy is a rare and serious syndrome... more...

Aliases & Classifications for Nephrogenic Systemic Fibrosis

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Sources:
43NIH Rare Diseases, 49Orphanet, 62UMLS, 28ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Nephrogenic Systemic Fibrosis, Aliases & Descriptions:

Name: Nephrogenic Systemic Fibrosis 43 49
Nephrogenic Fibrosing Dermopathy 43 49 62
Intractable Diarrhea - Choanal Atresia - Eye Anomalies 43 49
 
Nfd 43
Nsf 43


Classifications:



Characteristics (Orphanet epidemiological data):

49
intractable diarrhea - choanal atresia - eye anomalies:
Prevalence: <1/1000000 (Worldwide); Age of onset: Infancy,Neonatal


External Ids:

Orphanet49 137622, 137617
ICD10 via Orphanet28 Q87.8
UMLS via Orphanet63 C1619692

Related Diseases for Nephrogenic Systemic Fibrosis

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Diseases related to Nephrogenic Systemic Fibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1kidney disease31.0SPP1, SMAD2, TGFB1, CTGF
2keloids30.2SMAD2, SMAD3, F13A1, DCN, TGFB1, CTGF
3atherosclerosis30.1SPP1, F13A1, TIMP1, DCN, TGM2, TGFB1
4liver disease10.5
5pseudoxanthoma elasticum10.4
6uveitis10.4
7scleromyxedema10.4
8tubulointerstitial nephritis and uveitis10.4
9nephritis10.4
10sarcoma10.3
11neuronal intranuclear inclusion disease10.2
12kaposi sarcoma10.2
13hepatitis10.2
14spinal cord injury10.2
15pure red-cell aplasia10.2
16inflammatory breast carcinoma10.2
17hypercalcemia10.2
18fibrous histiocytoma10.2
19calciphylaxis10.2
20histiocytoma10.2
21hypothyroidism10.2
22meningitis10.2
23myopathy10.2
24panniculitis10.2
25respiratory failure10.2
26scleroderma10.2
27vasculitis10.2
28endotheliitis10.2
29retinitis pigmentosa10.0
30neuronitis10.0
31botulism10.0
32retinitis10.0
33myelofibrosis10.0TIMP1, EPO
34clear cell adenocarcinoma10.0SMAD3, SMAD2
35giant cell tumor10.0TIMP1, TGFB1
36localized scleroderma10.0F13A1, DCN
37abdominal aortic aneurysm10.0DCN, TIMP1
38pulmonary disease, chronic obstructive10.0TGFB1, TIMP1
39ureteral obstruction10.0TGFB1, SMAD3
40polycythemia10.0EPO, TIMP1
41vitreoretinopathy, neovascular inflammatory10.0CTGF, TGFB1, TIMP1
42ureteral disease10.0SMAD2, TGFB1, CTGF
43basal cell carcinoma10.0CYP27B1, F13A1, DCN
44rhabdomyosarcoma10.0CTGF, SMAD3, SMAD2
45liver cirrhosis10.0CTGF, TGFB1, TIMP1
46cork-handlers' disease10.0TGFB1, CCL7, CTGF
47malignant fibroxanthoma10.0CTGF, F13A1
48pneumonia10.0TGFB1, CXCL2, CCL7
49secondary hyperparathyroidism of renal origin10.0CYP27B1, EPO
50relapsing-remitting multiple sclerosis10.0TIMP1, SPP1

Graphical network of the top 20 diseases related to Nephrogenic Systemic Fibrosis:



Diseases related to nephrogenic systemic fibrosis

Symptoms for Nephrogenic Systemic Fibrosis

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Drugs & Therapeutics for Nephrogenic Systemic Fibrosis

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Drug clinical trials:

Search ClinicalTrials for Nephrogenic Systemic Fibrosis

Search NIH Clinical Center for Nephrogenic Systemic Fibrosis

Genetic Tests for Nephrogenic Systemic Fibrosis

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Anatomical Context for Nephrogenic Systemic Fibrosis

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MalaCards organs/tissues related to Nephrogenic Systemic Fibrosis:

33
Skin, Eye, Kidney, Testes, Liver, Bone, Spinal cord, Heart, Breast, T cells, Endothelial

Animal Models for Nephrogenic Systemic Fibrosis or affiliated genes

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MGI Mouse Phenotypes related to Nephrogenic Systemic Fibrosis:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7CTGF, TGFB1, DCN, SMAD3, SMAD2
2MP:00053908.6SPP1, CYP27B1, SMAD2, SMAD3, DCN, CTGF
3MP:00053828.6SMAD2, SMAD3, DCN, TGFB1, CTGF
4MP:00053678.4SPP1, CYP27B1, SMAD3, DCN, TGM2, TGFB1
5MP:00053918.4PIK3CA, SMAD2, SMAD3, DCN, TGFB1, CTGF
6MP:00053808.2PIK3CA, SMAD2, SMAD3, TGFB1, EPO, CTGF
7MP:00053798.2PIK3CA, CYP27B1, SMAD2, SMAD3, TIMP1, DCN
8MP:00053888.0SPP1, SMAD2, F13A1, TIMP1, DCN, TGFB1
9MP:00053708.0SPP1, SMAD2, SMAD3, TGFB1, EPO
10MP:00020067.7SPP1, PIK3CA, SMAD2, SMAD3, TIMP1, DCN
11MP:00053867.7SPP1, PIK3CA, SMAD2, SMAD3, DCN, TGM2
12MP:00107717.4SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, DCN
13MP:00053897.3SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, F13A1
14MP:00053877.2SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, TIMP1
15MP:00053787.2SMAD2, CYP27B1, PIK3CA, SPP1, SMAD3, TIMP1
16MP:00053857.0SMAD3, SMAD2, PIK3CA, SPP1, F13A1, TIMP1
17MP:00053977.0CCL7, SPP1, CYP27B1, SMAD2, SMAD3, F13A1
18MP:00053846.8SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, DCN
19MP:00053766.5SMAD3, SMAD2, CYP27B1, PIK3CA, SPP1, F13A1
20MP:00107686.4F13A1, SMAD3, SMAD2, PIK3CA, SPP1, TIMP1

Publications for Nephrogenic Systemic Fibrosis

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Articles related to Nephrogenic Systemic Fibrosis:

(show top 50)    (show all 397)
idTitleAuthorsYear
1
Compensatory biliary and urinary excretion of gadobenate ion after administration of gadobenate dimeglumine (MultiHance(Ar)) in cases of impaired hepatic or renal function: a mechanism that may aid in the prevention of nephrogenic systemic fibrosis? (25651409)
2015
2
Nephrogenic Systemic Fibrosis Risk After Liver Magnetic Resonance Imaging With Gadoxetate Disodium in Patients With Moderate to Severe Renal Impairment: Results of a Prospective, Open-Label, Multicenter Study. (25756684)
2015
3
Nephrogenic systemic fibrosis is associated with hypophosphataemia: a case-control study. (24706993)
2014
4
Substitution of gadolinium ethylenediaminetetraacetate with phosphites: towards gadolinium deposit in nephrogenic systemic fibrosis. (24132302)
2013
5
Nephrogenic systemic fibrosis in denmark- a nationwide investigation. (24349178)
2013
6
Contrast-induced nephropathy and nephrogenic systemic fibrosis: minimizing the risk. (22316507)
2012
7
Understanding nephrogenic systemic fibrosis. (23193473)
2012
8
Quantification of gadolinium in fresh skin and serum samples from patients with nephrogenic systemic fibrosis. (21036418)
2011
9
Nephrogenic systemic fibrosis and gadolinium-containing radiological contrast agents: an update. (21471962)
2011
10
Quantitative assessment of dermal cellularity in nephrogenic systemic fibrosis: a diagnostic aid. (21414498)
2011
11
Nephrogenic systemic fibrosis: a brief review. (21572794)
2011
12
Nephrogenic systemic fibrosis: clinicopathological definition and workup recommendations. (21724294)
2011
13
Gadolinium deposition in nephrogenic systemic fibrosis: an examination of tissue using synchrotron x-ray fluorescence spectroscopy. (19896750)
2010
14
Gadolinium-associated nephrogenic systemic fibrosis in patients with renal failure: the need for an interdisciplinary helping network. (20032228)
2010
15
Nephrogenic systemic fibrosis: a review. (20677539)
2010
16
Nephrogenic systemic fibrosis with a spectrum of clinical and histopathological presentation: a disorder of aberrant dermal remodeling. (19341434)
2010
17
Nephrogenic systemic fibrosis in a patient with spinal cord injury: a unique case presentation. (21145526)
2010
18
NFI_B activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis. (20959327)
2010
19
MRI safety: nephrogenic systemic fibrosis and other risks. (20542435)
2010
20
Estimates of risk, empirical treatment observations, and unexpected laboratory findings reveal the complexity of nephrogenic systemic fibrosis. (19841408)
2009
21
Nephrogenic systemic fibrosis in patients with chronic kidney disease who received gadopentetate dimeglumine. (19151610)
2009
22
Effects of gadolinium contrast agents in naA^ve and nephrectomized rats: relevance to nephrogenic systemic fibrosis. (19160079)
2009
23
Nephrogenic systemic fibrosis: clinical picture and treatment. (19744598)
2009
24
High-dose gadodiamide for catheter angiography and CT in patients with varying degrees of renal insufficiency: Prevalence of subsequent nephrogenic systemic fibrosis and decline in renal function. (19457816)
2009
25
Nephrogenic systemic fibrosis: incidence, associations, and effect of risk factor assessment--report of 33 cases. (19188312)
2009
26
Involvement of gadolinium chelates in the mechanism of nephrogenic systemic fibrosis: an update. (19744600)
2009
27
Nephrogenic systemic fibrosis and management of high-risk patients. (19375360)
2009
28
Nephrogenic systemic fibrosis in rats treated with erythropoietin and intravenous iron. (19789237)
2009
29
Nephrogenic systemic fibrosis: more questions and some answers. (18688172)
2008
30
Association of gadolinium based magnetic resonance imaging contrast agents and nephrogenic systemic fibrosis. (18635232)
2008
31
Nephrogenic systemic fibrosis: a new concern for rheumatologists. (18756271)
2008
32
An epidemic outbreak of nephrogenic systemic fibrosis in a Danish hospital. (18328659)
2008
33
Cardiac and vascular metal deposition with high mortality in nephrogenic systemic fibrosis. (18401336)
2008
34
Nephrogenic systemic fibrosis and gadolinium: a perfect storm. (18806157)
2008
35
Epoetin and nephrogenic systemic fibrosis. (18158932)
2008
36
Gadolinium-contrast toxicity in patients with kidney disease: nephrotoxicity and nephrogenic systemic fibrosis. (18690983)
2008
37
Nephrogenic systemic fibrosis: chronic imaging findings and review of the medical literature. (18324398)
2008
38
Nephrogenic systemic fibrosis associated with gadolinium use. (18400614)
2008
39
Treatment of nephrogenic systemic fibrosis with Re-PUVA. (18625379)
2008
40
Canadian Association of Radiologists national advisory on gadolinium administration and nephrogenic systemic fibrosis. (19385151)
2008
41
Nephrogenic systemic fibrosis: possible association with a predisposing infection. (18356457)
2008
42
Gadolinium-based contrast agents and their potential role in the pathogenesis of nephrogenic systemic fibrosis: the role of excess ligand. (18425843)
2008
43
A timely reminder about an evolving clinical entity: nephrogenic systemic fibrosis and gadolinium use in CKD. (17498132)
2007
44
Treatment with corticosteroids does not seem to benefit nephrogenic systemic fibrosis. (17602192)
2007
45
Safety update on the possible causal relationship between gadolinium-containing MRI agents and nephrogenic systemic fibrosis. (17457808)
2007
46
Long-term retention of gadolinium in tissues from nephrogenic systemic fibrosis patient after multiple gadolinium-enhanced MRI scans: case report and implications. (17712863)
2007
47
Nephrogenic systemic fibrosis associated with gadolinium-containing contrast media administration in patients with reduced glomerular filtration rate. (17504326)
2007
48
The role of the hospital dermatologist in the diagnosis and treatment of calciphylaxis and nephrogenic systemic fibrosis. (18070683)
2007
49
Nephrogenic systemic fibrosis--the beginning of the end? (17572281)
2007
50
Nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis with diaphragmatic involvement in a patient with respiratory failure. (16427988)
2006

Variations for Nephrogenic Systemic Fibrosis

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Expression for genes affiliated with Nephrogenic Systemic Fibrosis

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Search GEO for disease gene expression data for Nephrogenic Systemic Fibrosis.

Pathways for genes affiliated with Nephrogenic Systemic Fibrosis

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Pathways related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8SMAD3, SMAD2
29.8SMAD2, SMAD3
3
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b738
a4b1 and a4b7 Integrin signaling38
9.6PIK3CA, EPO
49.6EPO, PIK3CA
59.5SMAD2, TGFB1
69.4SMAD3, CYP27B1, SPP1
79.4EPO, TIMP1, PIK3CA
8
Show member pathways
9.4PIK3CA, SMAD2, SMAD3
99.4SMAD3, SMAD2, PIK3CA
10
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.4PIK3CA, SMAD2, SMAD3
119.2SMAD2, SMAD3, TGFB1
129.2TGFB1, SMAD3, SMAD2
13
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.2TGFB1, SMAD3, SMAD2
14
Show member pathways
9.2SMAD2, SMAD3, TGFB1
15
Show member pathways
9.2SMAD2, SMAD3, TGFB1
169.2TGFB1, SMAD3, SMAD2
17
Show member pathways
9.2TGFB1, SMAD3, SMAD2
18
Show member pathways
Cell cycle38
9.2TGFB1, SMAD3, SMAD2
19
Show member pathways
9.2SMAD2, SMAD3, TGFB1
209.2TGFB1, SMAD3, SMAD2
21
Show member pathways
9.2TGFB1, TIMP1, F13A1
22
Show member pathways
9.1TIMP1, TGFB1, CCL7, CTGF
23
Show member pathways
9.1TIMP1, TGM2, TGFB1, CTGF
24
Show member pathways
9.1TGFB1, TGM2, SPP1
259.1TGFB1, SMAD2, PIK3CA
26
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.1PIK3CA, SMAD3, TGFB1
279.0TGFB1, CXCL2
288.9CTGF, TGFB1, SMAD3, SMAD2
298.9SMAD2, SMAD3, TGFB1, CTGF
30
Show member pathways
8.9SMAD2, SMAD3, DCN, TGFB1
318.9SMAD2, SMAD3, DCN, TGFB1
328.8PIK3CA, SMAD2, DCN, TGFB1
33
Show member pathways
8.8SPP1, TIMP1, DCN, TGFB1
34
Show member pathways
8.8CTGF, CCL7, EPO, TGFB1, TIMP1
35
Show member pathways
Signal transduction PTEN pathway60
8.7PIK3CA, SMAD2, SMAD3, TGFB1
368.7PIK3CA, SMAD2, SMAD3, TGFB1
37
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
8.7PIK3CA, SMAD2, SMAD3, TGFB1
388.7PIK3CA, SMAD2, SMAD3, TGFB1
39
Show member pathways
8.7PIK3CA, SMAD2, SMAD3, TGFB1
40
Show member pathways
8.7TGFB1, SMAD3, SMAD2, PIK3CA
41
Show member pathways
8.7PIK3CA, F13A1, TIMP1, TGFB1
428.7SPP1, SMAD2, SMAD3, TGFB1
43
Show member pathways
8.3TIMP1, TGFB1, CXCL2, CCL7, CTGF
44
Show member pathways
8.3TIMP1, TGFB1, CXCL2, CCL7, CTGF
45
Show member pathways
8.3SPP1, TGFB1, CXCL2, CCL7
46
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.2SPP1, PIK3CA, SMAD2, SMAD3, TGFB1
47
Show member pathways
8.2TIMP1, TGFB1, EPO, CXCL2, CCL7
488.1PIK3CA, SMAD2, SMAD3, DCN, TGFB1, MAPKAP1
49
Show member pathways
7.8SPP1, TIMP1, TGFB1, CXCL2, CCL7, CTGF
50
Show member pathways
6.9SPP1, PIK3CA, SMAD2, SMAD3, TGFB1, CXCL2

Compounds for genes affiliated with Nephrogenic Systemic Fibrosis

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Compounds related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1tranilast459.6TGFB1, TIMP1, SMAD2
2aristolochic acid45 310.5CTGF, TGFB1, TIMP1
3hydroxyproline45 26 1311.4TIMP1, DCN, TGFB1, CTGF
4retinoid459.2SPP1, CYP27B1, TIMP1, TGM2, CTGF
5alginate459.2SPP1, TIMP1, DCN, TGFB1
6lysine459.0CYP27B1, SMAD2, SMAD3, F13A1, DCN, TGM2
7curcumin459.0SPP1, TIMP1, TGFB1, CCL7, CTGF
8genistein45 30 61 3 26 1313.9SPP1, PIK3CA, CYP27B1, TIMP1, DCN, CCL7
9calcitriol45 61 26 1311.8SPP1, CYP27B1, TIMP1, TGFB1, EPO
101,25 dihydroxy vitamin d3458.8SPP1, CYP27B1, SMAD3, TGFB1
11n acetylcysteine458.7SMAD2, SMAD3, TIMP1, CXCL2, CTGF
12ribonucleic acid458.7SPP1, TIMP1, DCN, TGFB1, CCL7, CTGF
13rapamycin458.7CTGF, EPO, TGM2, SMAD3, PIK3CA
14cysteine458.6SPP1, CYP27B1, SMAD2, TIMP1, DCN, TGM2
15heparin45 30 26 1311.6SPP1, PIK3CA, F13A1, TIMP1, DCN, CTGF
16butyrate458.5SPP1, SMAD3, TIMP1, TGFB1, EPO
17paraffin458.5SPP1, CYP27B1, F13A1, TIMP1, DCN, TGFB1
18rantes458.5TIMP1, TGFB1, CXCL2, CCL7, MAPKAP1
19vitamin d458.5SPP1, CYP27B1, SMAD3, TIMP1, TGFB1, EPO
20cholesterol45 30 26 1311.4SPP1, PIK3CA, CYP27B1, SMAD3, TIMP1, DCN
21cycloheximide458.4SPP1, CYP27B1, SMAD3, TIMP1, TGFB1, CCL7
22thymidine45 269.4PIK3CA, SMAD2, SMAD3, TGFB1, EPO, CTGF
23fibrinogen458.3SPP1, F13A1, TGM2, CXCL2, CTGF
24hyaluronic acid45 269.3SPP1, TIMP1, DCN, TGFB1, CXCL2
25tgf beta1458.3SPP1, SMAD2, SMAD3, TIMP1, DCN, TGFB1
26glucose458.2SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, DCN
27alanine458.2SPP1, SMAD2, SMAD3, TIMP1, DCN, TGM2
28cyclosporin a45 30 6110.1SPP1, PIK3CA, TIMP1, DCN, TGFB1, EPO
29actinomycin d458.1SPP1, PIK3CA, TIMP1, TGFB1, CCL7
30nitric oxide45 26 1310.1PIK3CA, SMAD2, SMAD3, TIMP1, DCN, CXCL2
31matrigel458.1SPP1, PIK3CA, SMAD2, SMAD3, TIMP1, DCN
32threonine458.0SPP1, PIK3CA, SMAD2, SMAD3, TGM2, TGFB1
33h2o2458.0SPP1, PIK3CA, SMAD2, TIMP1, CXCL2, CTGF
34retinoic acid45 269.0SPP1, PIK3CA, CYP27B1, TIMP1, DCN, TGM2
35bleomycin45 139.0CTGF, SPP1, EPO, TGFB1, DCN, TIMP1
36oxygen45 268.9SPP1, CYP27B1, DCN, TGM2, EPO, CXCL2
37procollagen457.9SPP1, SMAD2, SMAD3, F13A1, TIMP1, DCN
38pge2457.9SPP1, CYP27B1, TIMP1, DCN, TGFB1, CXCL2
39sb 20358045 618.8SPP1, SMAD2, SMAD3, TIMP1, TGFB1, CXCL2
40lipid457.6CTGF, CCL7, CXCL2, SMAD3, CYP27B1, PIK3CA
41lactate457.6SPP1, PIK3CA, TIMP1, TGFB1, EPO, CXCL2
42dexamethasone45 51 30 1310.2SPP1, PIK3CA, SMAD2, TIMP1, DCN, TGFB1
43pd 98,059457.0SPP1, PIK3CA, SMAD2, SMAD3, TIMP1, DCN
44calcium45 51 26 1310.0SPP1, PIK3CA, CYP27B1, F13A1, TGM2, CXCL2
45ly294002456.9SPP1, PIK3CA, SMAD2, SMAD3, TIMP1, TGFB1
46oligonucleotide456.9SPP1, CYP27B1, SMAD2, SMAD3, F13A1, DCN
47tyrosine456.8SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, TIMP1
48estrogen456.7SPP1, PIK3CA, CYP27B1, SMAD3, F13A1, TIMP1
49serine456.5SPP1, PIK3CA, SMAD2, SMAD3, TIMP1, DCN
50vegf456.3SPP1, PIK3CA, SMAD2, SMAD3, F13A1, TIMP1

GO Terms for genes affiliated with Nephrogenic Systemic Fibrosis

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Cellular components related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SMAD protein complexGO:00711419.8SMAD3, SMAD2
2platelet alpha granule lumenGO:00310938.9TGFB1, TIMP1, F13A1
3extracellular spaceGO:00056157.3SPP1, DCN, TGFB1, EPO, CXCL2, CCL7
4extracellular regionGO:00055766.7CTGF, SPP1, F13A1, TIMP1, DCN, TGFB1

Biological processes related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1paraxial mesoderm morphogenesisGO:004834010.2SMAD3, SMAD2
2nodal signaling pathwayGO:003809210.2SMAD2, SMAD3
3primary miRNA processingGO:003105310.2SMAD2, SMAD3
4erythrocyte maturationGO:004324910.2TIMP1, EPO
5pericardium developmentGO:006003910.2SMAD3, SMAD2
6embryonic foregut morphogenesisGO:004861710.2SMAD3, SMAD2
7activin receptor signaling pathwayGO:003292410.1SMAD3, SMAD2
8signal transduction involved in regulation of gene expressionGO:002301910.0SMAD3, SMAD2
9decidualizationGO:004669710.0CYP27B1, SPP1
10embryonic cranial skeleton morphogenesisGO:004870110.0SMAD2, SMAD3
11evasion or tolerance of host defenses by virusGO:00190499.9TGFB1, SMAD3
12response to lipopolysaccharideGO:00324969.9EPO, DCN, CYP27B1
13common-partner SMAD protein phosphorylationGO:00071829.9SMAD2, TGFB1
14response to cholesterolGO:00707239.9TGFB1, SMAD2
15regulation of striated muscle tissue developmentGO:00162029.9TGFB1, SMAD3
16lens fiber cell differentiationGO:00703069.9TGFB1, SMAD3
17developmental growthGO:00485899.9SMAD3, SMAD2
18positive regulation of collagen biosynthetic processGO:00329679.8TGFB1, CTGF
19mesoderm formationGO:00017079.8SMAD2, SMAD3
20negative regulation of mitotic cell cycleGO:00459309.8SMAD3, TGFB1
21extracellular matrix disassemblyGO:00226179.8DCN, TIMP1, SPP1
22transcription initiation from RNA polymerase II promoterGO:00063679.7CTGF, SMAD3, SMAD2
23fibroblast growth factor receptor signaling pathwayGO:00085439.7CTGF, MAPKAP1, PIK3CA
24endoderm developmentGO:00074929.7TGFB1, SMAD3
25response to glucoseGO:00097499.7SMAD2, TGFB1, CTGF
26regulation of bindingGO:00510989.6TGFB1, SMAD3, SMAD2
27SMAD protein complex assemblyGO:00071839.6TGFB1, SMAD3, SMAD2
28regulation of transforming growth factor beta receptor signaling pathwayGO:00170159.6TGFB1, SMAD3, SMAD2
29negative regulation of cell growthGO:00303089.6CYP27B1, SMAD3, TGFB1
30positive regulation of epithelial to mesenchymal transitionGO:00107189.6TGFB1, SMAD3, SMAD2
31ureteric bud developmentGO:00016579.6SMAD2, SMAD3, TGFB1
32positive regulation of cell migrationGO:00303359.6SMAD3, TGFB1, CCL7
33negative regulation of transforming growth factor beta receptor signaling pathwayGO:00305129.6TGFB1, SMAD3, SMAD2
34platelet degranulationGO:00025769.6F13A1, TIMP1, TGFB1
35response to vitamin DGO:00332809.5SPP1, CYP27B1, TGFB1
36transforming growth factor beta receptor signaling pathwayGO:00071799.5TGFB1, SMAD3, SMAD2
37agingGO:00075689.4TIMP1, DCN, TGFB1, EPO
38protein kinase B signalingGO:00434919.3TGFB1, PIK3CA
39in utero embryonic developmentGO:00017019.3RCN1, SMAD3, SMAD2
40positive regulation of cell proliferationGO:00082849.3CTGF, EPO, TGFB1, TIMP1
41epidermal growth factor receptor signaling pathwayGO:00071739.2MAPKAP1, TGFB1, PIK3CA
42positive regulation of bone mineralizationGO:00305019.2TGFB1, SMAD3
43extracellular matrix organizationGO:00301989.2SPP1, TIMP1, DCN, TGFB1
44platelet activationGO:00301689.1TGFB1, TIMP1, F13A1, PIK3CA
45positive regulation of transcription, DNA-templatedGO:00458939.1SMAD2, SMAD3, TGFB1, EPO
46blood coagulationGO:00075969.0TGFB1, TIMP1, F13A1, PIK3CA
47inflammatory responseGO:00069548.7CCL7, CXCL2, TGFB1, SPP1

Molecular functions related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activityGO:003061810.0SMAD2, SMAD3
2protein-glutamine gamma-glutamyltransferase activityGO:00038109.9TGM2, F13A1
3co-SMAD bindingGO:00704109.9SMAD2, SMAD3
4transforming growth factor beta receptor bindingGO:00051609.8SMAD2, SMAD3
5extracellular matrix bindingGO:00508409.7DCN, SPP1
6protein kinase activator activityGO:00302959.5EPO, PIK3CA
7R-SMAD bindingGO:00704129.5SMAD3, SMAD2
8protein bindingGO:00055156.1CTGF, PIK3CA, SMAD2, SMAD3, TIMP1, TGM2

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4CDC
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