NFD
MCID: NPH018
MIFTS: 58

Nephrogenic Systemic Fibrosis (NFD) malady

Rare diseases, Skin diseases, Nephrological diseases categories
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Summaries for Nephrogenic Systemic Fibrosis

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NIH Rare Diseases:42 Nephrogenic systemic fibrosis is a condition that affects different parts of the body, particularly the skin. symptoms of the condition may include progressive swelling and tightening of the skin, sometimes resulting in contractures, and pruritis (itching).  the skin findings are similar to those seen in patients with scleroderma.  nephrogenic systemic fibrosis was first described in 1997. being exposed to gadolinium-containing contrast agents during mri testing has been identified as a significant risk factor for development of this disease. last updated: 4/24/2013

MalaCards based summary: Nephrogenic Systemic Fibrosis, also known as nephrogenic fibrosing dermopathy, is related to keloids and atherosclerosis. An important gene associated with Nephrogenic Systemic Fibrosis is CCL7 (chemokine (C-C motif) ligand 7), and among its related pathways are Signaling by NODAL and Regulation of cytoplasmic and nuclear SMAD2/3 signaling. The compounds tranilast and aristolochic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and eye, and related mouse phenotypes are digestive/alimentary and skeleton.

Wikipedia:65 Nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy is a rare and serious syndrome... more...

Aliases & Classifications for Nephrogenic Systemic Fibrosis

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Sources:
42NIH Rare Diseases, 48Orphanet, 62UMLS, 63UMLS via Orphanet
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Nephrogenic Systemic Fibrosis, Aliases & Descriptions:

Name: Nephrogenic Systemic Fibrosis 42 48
Nephrogenic Fibrosing Dermopathy 42 48 62
 
Nfd 42
Nsf 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Nephrological diseases
Orphanet: 48 
Rare skin diseases


External Ids:

UMLS via Orphanet63 C1619692

Related Diseases for Nephrogenic Systemic Fibrosis

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Diseases related to Nephrogenic Systemic Fibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 98)
idRelated DiseaseScoreTop Affiliating Genes
1keloids29.7SMAD2, CTGF, TGFB1, DCN, F13A1, SMAD3
2atherosclerosis29.3DCN, CTGF, TGM2, SPP1, TGFB1, F13A1
3kidney disease10.7
4liver disease10.5
5pseudoxanthoma elasticum10.4
6uveitis10.4
7scleromyxedema10.4
8tubulointerstitial nephritis and uveitis10.4
9nephritis10.4
10sarcoma10.3
11myelofibrosis10.3EPO, TIMP1
12epithelial-myoepithelial carcinoma10.3SMAD3, SMAD2
13lung giant cell carcinoma10.3TIMP1, TGFB1
14localized scleroderma10.3DCN, F13A1
15chronic obstructive pulmonary disease10.2TGFB1, TIMP1
16ureteral obstruction10.2TGFB1, SMAD3
17abdominal aortic aneurysm10.2DCN, TIMP1
18neuronal intranuclear inclusion disease10.2
19polycythemia10.2TIMP1, EPO
20diabetes mellitus10.2
21spinal cord injury10.2
22pure red-cell aplasia10.2
23inflammatory breast carcinoma10.2
24hypercalcemia10.2
25fibrous histiocytoma10.2
26calciphylaxis10.2
27histiocytoma10.2
28hypothyroidism10.2
29meningitis10.2
30myopathy10.2
31panniculitis10.2
32respiratory failure10.2
33scleroderma10.2
34vasculitis10.2
35endotheliitis10.2
36proliferative vitreoretinopathy10.2TIMP1, TGFB1, CTGF
37ureteral disease10.2SMAD2, TGFB1, CTGF
38basal cell carcinoma10.1F13A1, DCN, CYP27B1
39rhabdomyosarcoma10.1CTGF, SMAD2, SMAD3
40liver cirrhosis10.1CTGF, TGFB1, TIMP1
41cork-handlers' disease10.1CCL7, CTGF, TGFB1
42malignant fibroxanthoma10.1F13A1, CTGF
43pneumonia10.1TGFB1, CXCL2, CCL7
44secondary hyperparathyroidism of renal origin10.1CYP27B1, EPO
45cervical cancer10.1CCL7, PIK3CA, CYP27B1
46relapsing-remitting multiple sclerosis10.1TIMP1, SPP1
47inflammatory bowel disease10.1CYP27B1, F13A1, CCL7, TGM2
48gingival overgrowth10.1CTGF, TIMP1, TGFB1, DCN
49arthritis10.0CTGF, CXCL2, TIMP1, TGFB1
50vascular disease10.0CTGF, DCN, F13A1

Graphical network of the top 20 diseases related to Nephrogenic Systemic Fibrosis:



Diseases related to nephrogenic systemic fibrosis

Symptoms for Nephrogenic Systemic Fibrosis

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Drugs & Therapeutics for Nephrogenic Systemic Fibrosis

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Drug clinical trials:

Search ClinicalTrials for Nephrogenic Systemic Fibrosis

Search NIH Clinical Center for Nephrogenic Systemic Fibrosis

Genetic Tests for Nephrogenic Systemic Fibrosis

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Anatomical Context for Nephrogenic Systemic Fibrosis

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MalaCards organs/tissues related to Nephrogenic Systemic Fibrosis:

32
Skin, Kidney, Eye, Testes, Liver, Bone, Spinal cord, Heart, Breast, T cells, Endothelial

Animal Models for Nephrogenic Systemic Fibrosis or affiliated genes

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MGI Mouse Phenotypes related to Nephrogenic Systemic Fibrosis:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7CTGF, TGFB1, DCN, SMAD3, SMAD2
2MP:00053908.6SPP1, CYP27B1, SMAD2, SMAD3, DCN, CTGF
3MP:00053828.6SMAD2, SMAD3, DCN, TGFB1, CTGF
4MP:00053678.4SPP1, CYP27B1, SMAD3, DCN, TGM2, TGFB1
5MP:00053918.4PIK3CA, SMAD2, SMAD3, DCN, TGFB1, CTGF
6MP:00053808.2PIK3CA, SMAD2, SMAD3, TGFB1, EPO, CTGF
7MP:00053798.2PIK3CA, CYP27B1, SMAD2, SMAD3, TIMP1, DCN
8MP:00053888.0SPP1, SMAD2, F13A1, TIMP1, DCN, TGFB1
9MP:00053708.0SPP1, SMAD2, SMAD3, TGFB1, EPO
10MP:00020067.7SPP1, PIK3CA, SMAD2, SMAD3, TIMP1, DCN
11MP:00053867.7SPP1, PIK3CA, SMAD2, SMAD3, DCN, TGM2
12MP:00107717.4SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, DCN
13MP:00053897.3SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, F13A1
14MP:00053877.2SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, TIMP1
15MP:00053787.2SMAD2, CYP27B1, PIK3CA, SPP1, SMAD3, TIMP1
16MP:00053857.0SMAD3, SMAD2, PIK3CA, SPP1, F13A1, TIMP1
17MP:00053977.0CCL7, SPP1, CYP27B1, SMAD2, SMAD3, F13A1
18MP:00053846.8SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, DCN
19MP:00053766.5SMAD3, SMAD2, CYP27B1, PIK3CA, SPP1, F13A1
20MP:00107686.4F13A1, SMAD3, SMAD2, PIK3CA, SPP1, TIMP1

Publications for Nephrogenic Systemic Fibrosis

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Articles related to Nephrogenic Systemic Fibrosis:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Nephrogenic systemic fibrosis is associated with hypophosphataemia: a case-control study. (24706993)
2014
2
Substitution of gadolinium ethylenediaminetetraacetate with phosphites: towards gadolinium deposit in nephrogenic systemic fibrosis. (24132302)
2013
3
Nephrogenic systemic fibrosis in denmark- a nationwide investigation. (24349178)
2013
4
Contrast-induced nephropathy and nephrogenic systemic fibrosis: minimizing the risk. (22316507)
2012
5
Understanding nephrogenic systemic fibrosis. (23193473)
2012
6
Quantification of gadolinium in fresh skin and serum samples from patients with nephrogenic systemic fibrosis. (21036418)
2011
7
Nephrogenic systemic fibrosis and gadolinium-containing radiological contrast agents: an update. (21471962)
2011
8
Quantitative assessment of dermal cellularity in nephrogenic systemic fibrosis: a diagnostic aid. (21414498)
2011
9
Nephrogenic systemic fibrosis: a brief review. (21572794)
2011
10
Nephrogenic systemic fibrosis: clinicopathological definition and workup recommendations. (21724294)
2011
11
"Carcinoid-like" tricuspid valvulopathy associated with nephrogenic systemic fibrosis. (21366687)
2011
12
Gadolinium deposition in nephrogenic systemic fibrosis: an examination of tissue using synchrotron x-ray fluorescence spectroscopy. (19896750)
2010
13
Gadolinium-associated nephrogenic systemic fibrosis in patients with renal failure: the need for an interdisciplinary helping network. (20032228)
2010
14
Nephrogenic systemic fibrosis: a review. (20677539)
2010
15
Nephrogenic systemic fibrosis with a spectrum of clinical and histopathological presentation: a disorder of aberrant dermal remodeling. (19341434)
2010
16
Nephrogenic systemic fibrosis in a patient with spinal cord injury: a unique case presentation. (21145526)
2010
17
NFI_B activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis. (20959327)
2010
18
MRI safety: nephrogenic systemic fibrosis and other risks. (20542435)
2010
19
Estimates of risk, empirical treatment observations, and unexpected laboratory findings reveal the complexity of nephrogenic systemic fibrosis. (19841408)
2009
20
Nephrogenic systemic fibrosis in patients with chronic kidney disease who received gadopentetate dimeglumine. (19151610)
2009
21
Effects of gadolinium contrast agents in naA^ve and nephrectomized rats: relevance to nephrogenic systemic fibrosis. (19160079)
2009
22
Nephrogenic systemic fibrosis: clinical picture and treatment. (19744598)
2009
23
High-dose gadodiamide for catheter angiography and CT in patients with varying degrees of renal insufficiency: Prevalence of subsequent nephrogenic systemic fibrosis and decline in renal function. (19457816)
2009
24
Nephrogenic systemic fibrosis: incidence, associations, and effect of risk factor assessment--report of 33 cases. (19188312)
2009
25
Involvement of gadolinium chelates in the mechanism of nephrogenic systemic fibrosis: an update. (19744600)
2009
26
Nephrogenic systemic fibrosis and management of high-risk patients. (19375360)
2009
27
Nephrogenic systemic fibrosis in rats treated with erythropoietin and intravenous iron. (19789237)
2009
28
Nephrogenic systemic fibrosis: more questions and some answers. (18688172)
2008
29
Association of gadolinium based magnetic resonance imaging contrast agents and nephrogenic systemic fibrosis. (18635232)
2008
30
Nephrogenic systemic fibrosis: a new concern for rheumatologists. (18756271)
2008
31
An epidemic outbreak of nephrogenic systemic fibrosis in a Danish hospital. (18328659)
2008
32
Cardiac and vascular metal deposition with high mortality in nephrogenic systemic fibrosis. (18401336)
2008
33
Nephrogenic systemic fibrosis and gadolinium: a perfect storm. (18806157)
2008
34
Epoetin and nephrogenic systemic fibrosis. (18158932)
2008
35
Gadolinium-contrast toxicity in patients with kidney disease: nephrotoxicity and nephrogenic systemic fibrosis. (18690983)
2008
36
Nephrogenic systemic fibrosis: chronic imaging findings and review of the medical literature. (18324398)
2008
37
Nephrogenic systemic fibrosis associated with gadolinium use. (18400614)
2008
38
Treatment of nephrogenic systemic fibrosis with Re-PUVA. (18625379)
2008
39
Canadian Association of Radiologists national advisory on gadolinium administration and nephrogenic systemic fibrosis. (19385151)
2008
40
Nephrogenic systemic fibrosis: possible association with a predisposing infection. (18356457)
2008
41
Gadolinium-based contrast agents and their potential role in the pathogenesis of nephrogenic systemic fibrosis: the role of excess ligand. (18425843)
2008
42
Gadolinium-associated nephrogenic systemic fibrosis. (19920874)
2008
43
A timely reminder about an evolving clinical entity: nephrogenic systemic fibrosis and gadolinium use in CKD. (17498132)
2007
44
Treatment with corticosteroids does not seem to benefit nephrogenic systemic fibrosis. (17602192)
2007
45
Safety update on the possible causal relationship between gadolinium-containing MRI agents and nephrogenic systemic fibrosis. (17457808)
2007
46
Long-term retention of gadolinium in tissues from nephrogenic systemic fibrosis patient after multiple gadolinium-enhanced MRI scans: case report and implications. (17712863)
2007
47
Nephrogenic systemic fibrosis associated with gadolinium-containing contrast media administration in patients with reduced glomerular filtration rate. (17504326)
2007
48
The role of the hospital dermatologist in the diagnosis and treatment of calciphylaxis and nephrogenic systemic fibrosis. (18070683)
2007
49
Nephrogenic systemic fibrosis--the beginning of the end? (17572281)
2007
50
Nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis with diaphragmatic involvement in a patient with respiratory failure. (16427988)
2006

Variations for Nephrogenic Systemic Fibrosis

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Expression for genes affiliated with Nephrogenic Systemic Fibrosis

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Expression patterns in normal tissues for genes affiliated with Nephrogenic Systemic Fibrosis

Search GEO for disease gene expression data for Nephrogenic Systemic Fibrosis.

Pathways for genes affiliated with Nephrogenic Systemic Fibrosis

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Pathways related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8SMAD3, SMAD2
29.8SMAD2, SMAD3
3
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b737
a4b1 and a4b7 Integrin signaling37
9.6PIK3CA, EPO
49.6EPO, PIK3CA
59.5SMAD2, TGFB1
69.4SMAD3, CYP27B1, SPP1
79.4EPO, TIMP1, PIK3CA
8
Show member pathways
9.4PIK3CA, SMAD2, SMAD3
99.4SMAD3, SMAD2, PIK3CA
10
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.4PIK3CA, SMAD2, SMAD3
119.2SMAD2, SMAD3, TGFB1
129.2TGFB1, SMAD3, SMAD2
13
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.2TGFB1, SMAD3, SMAD2
14
Show member pathways
9.2SMAD2, SMAD3, TGFB1
15
Show member pathways
9.2SMAD2, SMAD3, TGFB1
169.2TGFB1, SMAD3, SMAD2
17
Show member pathways
9.2TGFB1, SMAD3, SMAD2
18
Show member pathways
Cell cycle37
9.2TGFB1, SMAD3, SMAD2
19
Show member pathways
9.2SMAD2, SMAD3, TGFB1
209.2TGFB1, SMAD3, SMAD2
21
Show member pathways
9.2TGFB1, TIMP1, F13A1
22
Show member pathways
9.1TIMP1, TGFB1, CCL7, CTGF
23
Show member pathways
9.1TIMP1, TGM2, TGFB1, CTGF
24
Show member pathways
9.1TGFB1, TGM2, SPP1
259.1TGFB1, SMAD2, PIK3CA
26
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.1PIK3CA, SMAD3, TGFB1
279.0TGFB1, CXCL2
288.9CTGF, TGFB1, SMAD3, SMAD2
298.9SMAD2, SMAD3, TGFB1, CTGF
30
Show member pathways
8.9SMAD2, SMAD3, DCN, TGFB1
318.9SMAD2, SMAD3, DCN, TGFB1
328.8PIK3CA, SMAD2, DCN, TGFB1
33
Show member pathways
8.8SPP1, TIMP1, DCN, TGFB1
34
Show member pathways
8.8CTGF, CCL7, EPO, TGFB1, TIMP1
35
Show member pathways
Signal transduction PTEN pathway60
8.7PIK3CA, SMAD2, SMAD3, TGFB1
368.7PIK3CA, SMAD2, SMAD3, TGFB1
37
Show member pathways
PLK2 and PLK4 events37
Polo-like kinase signaling events in the cell cycle37
8.7PIK3CA, SMAD2, SMAD3, TGFB1
388.7PIK3CA, SMAD2, SMAD3, TGFB1
39
Show member pathways
8.7PIK3CA, SMAD2, SMAD3, TGFB1
40
Show member pathways
8.7TGFB1, SMAD3, SMAD2, PIK3CA
41
Show member pathways
8.7PIK3CA, F13A1, TIMP1, TGFB1
428.7SPP1, SMAD2, SMAD3, TGFB1
43
Show member pathways
8.3TIMP1, TGFB1, CXCL2, CCL7, CTGF
44
Show member pathways
8.3TIMP1, TGFB1, CXCL2, CCL7, CTGF
45
Show member pathways
8.3SPP1, TGFB1, CXCL2, CCL7
46
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.2SPP1, PIK3CA, SMAD2, SMAD3, TGFB1
47
Show member pathways
8.2TIMP1, TGFB1, EPO, CXCL2, CCL7
488.1PIK3CA, SMAD2, SMAD3, DCN, TGFB1, MAPKAP1
49
Show member pathways
7.8SPP1, TIMP1, TGFB1, CXCL2, CCL7, CTGF
50
Show member pathways
6.9SPP1, PIK3CA, SMAD2, SMAD3, TGFB1, CXCL2

Compounds for genes affiliated with Nephrogenic Systemic Fibrosis

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Compounds related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1tranilast449.6TGFB1, SMAD2, TIMP1
2aristolochic acid44 210.5TGFB1, TIMP1, CTGF
3hydroxyproline44 24 1111.4DCN, TGFB1, CTGF, TIMP1
4retinoid449.2CTGF, SPP1, CYP27B1, TIMP1, TGM2
5alginate449.2SPP1, TIMP1, TGFB1, DCN
6lysine449.0DCN, CYP27B1, SMAD2, SMAD3, F13A1, TGM2
7curcumin449.0TIMP1, SPP1, CTGF, CCL7, TGFB1
8genistein44 28 61 2 24 1113.9PIK3CA, DCN, CCL7, SPP1, TIMP1, CYP27B1
9calcitriol44 61 24 1111.8CYP27B1, EPO, SPP1, TGFB1, TIMP1
101,25 dihydroxy vitamin d3448.8CYP27B1, SPP1, TGFB1, SMAD3
11n acetylcysteine448.7SMAD2, CTGF, CXCL2, TIMP1, SMAD3
12ribonucleic acid448.7SPP1, TGFB1, DCN, TIMP1, CCL7, CTGF
13rapamycin448.7EPO, PIK3CA, CTGF, SMAD3, TGM2
14cysteine448.6CTGF, TGM2, DCN, SMAD2, CYP27B1, SPP1
15heparin44 28 24 1111.6SPP1, DCN, PIK3CA, F13A1, TIMP1, CTGF
16butyrate448.5SPP1, SMAD3, TIMP1, EPO, TGFB1
17paraffin448.5DCN, TIMP1, SPP1, TGFB1, CYP27B1, F13A1
18rantes448.5TIMP1, TGFB1, CXCL2, CCL7, MAPKAP1
19vitamin d448.5SPP1, CYP27B1, SMAD3, TIMP1, EPO, TGFB1
20cholesterol44 28 24 1111.4PIK3CA, SPP1, DCN, TIMP1, SMAD3, CYP27B1
21cycloheximide448.4CYP27B1, TIMP1, CTGF, SMAD3, SPP1, TGFB1
22thymidine44 249.4SMAD3, SMAD2, PIK3CA, TGFB1, EPO, CTGF
23fibrinogen448.3TGM2, CXCL2, SPP1, CTGF, F13A1
24hyaluronic acid44 249.3CXCL2, TGFB1, DCN, TIMP1, SPP1
25tgf beta1448.3CTGF, TGFB1, DCN, TIMP1, SMAD3, SPP1
26glucose448.2SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, DCN
27alanine448.2SMAD2, SPP1, TGFB1, DCN, TGM2, TIMP1
28cyclosporin a44 28 6110.1EPO, TGFB1, DCN, TIMP1, SPP1, PIK3CA
29actinomycin d448.1CCL7, TGFB1, TIMP1, PIK3CA, SPP1
30nitric oxide44 24 1110.1SMAD2, PIK3CA, CXCL2, SMAD3, TIMP1, DCN
31matrigel448.1SMAD2, PIK3CA, TIMP1, DCN, SPP1, TGFB1
32threonine448.0SPP1, CTGF, TGFB1, TGM2, SMAD3, SMAD2
33h2o2448.0PIK3CA, SPP1, TIMP1, CXCL2, CTGF, SMAD2
34retinoic acid44 249.0CTGF, TGM2, TGFB1, DCN, TIMP1, CYP27B1
35bleomycin44 118.9SPP1, EPO, CTGF, TGFB1, DCN, TIMP1
36oxygen44 248.9SPP1, DCN, TGM2, EPO, CXCL2, CCL7
37procollagen447.9TIMP1, TGFB1, CTGF, DCN, F13A1, SMAD3
38pge2447.9CXCL2, TGFB1, CTGF, TIMP1, CYP27B1, SPP1
39sb 20358044 618.8TGFB1, SPP1, SMAD2, SMAD3, TIMP1, CXCL2
40lipid447.6CCL7, CXCL2, CYP27B1, SMAD3, PIK3CA, CTGF
41lactate447.6CTGF, CXCL2, EPO, TGFB1, PIK3CA, TIMP1
42dexamethasone44 50 28 1110.2PIK3CA, SMAD2, DCN, TGFB1, CXCL2, CCL7
43pd 98,059447.0CXCL2, SPP1, PIK3CA, SMAD2, SMAD3, TIMP1
44calcium44 50 24 1110.0CXCL2, CYP27B1, F13A1, TGM2, CTGF, CCL7
45ly294002446.9CTGF, SPP1, PIK3CA, SMAD2, SMAD3, TIMP1
46oligonucleotide446.9DCN, SMAD2, CYP27B1, SPP1, CTGF, CCL7
47tyrosine446.8SPP1, PIK3CA, CYP27B1, TIMP1, EPO, CXCL2
48estrogen446.7TGFB1, DCN, PIK3CA, SPP1, CYP27B1, SMAD3
49serine446.5SMAD3, PIK3CA, SMAD2, SPP1, TIMP1, TGM2
50vegf446.3PIK3CA, SMAD2, SMAD3, F13A1, TIMP1, SPP1

GO Terms for genes affiliated with Nephrogenic Systemic Fibrosis

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Cellular components related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SMAD protein complexGO:0711419.8SMAD3, SMAD2
2platelet alpha granule lumenGO:0310938.9TGFB1, TIMP1, F13A1
3extracellular spaceGO:0056157.3SPP1, DCN, TGFB1, EPO, CXCL2, CCL7
4extracellular regionGO:0055766.7CTGF, SPP1, F13A1, TIMP1, DCN, TGFB1

Biological processes related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1paraxial mesoderm morphogenesisGO:04834010.2SMAD3, SMAD2
2nodal signaling pathwayGO:03809210.2SMAD2, SMAD3
3primary miRNA processingGO:03105310.2SMAD2, SMAD3
4erythrocyte maturationGO:04324910.2TIMP1, EPO
5pericardium developmentGO:06003910.2SMAD3, SMAD2
6embryonic foregut morphogenesisGO:04861710.2SMAD3, SMAD2
7activin receptor signaling pathwayGO:03292410.1SMAD3, SMAD2
8signal transduction involved in regulation of gene expressionGO:02301910.0SMAD3, SMAD2
9decidualizationGO:04669710.0CYP27B1, SPP1
10embryonic cranial skeleton morphogenesisGO:04870110.0SMAD2, SMAD3
11evasion or tolerance of host defenses by virusGO:0190499.9TGFB1, SMAD3
12response to lipopolysaccharideGO:0324969.9EPO, DCN, CYP27B1
13common-partner SMAD protein phosphorylationGO:0071829.9SMAD2, TGFB1
14response to cholesterolGO:0707239.9TGFB1, SMAD2
15regulation of striated muscle tissue developmentGO:0162029.9TGFB1, SMAD3
16lens fiber cell differentiationGO:0703069.9TGFB1, SMAD3
17developmental growthGO:0485899.9SMAD3, SMAD2
18positive regulation of collagen biosynthetic processGO:0329679.8TGFB1, CTGF
19mesoderm formationGO:0017079.8SMAD2, SMAD3
20negative regulation of mitotic cell cycleGO:0459309.8SMAD3, TGFB1
21extracellular matrix disassemblyGO:0226179.8DCN, TIMP1, SPP1
22transcription initiation from RNA polymerase II promoterGO:0063679.7CTGF, SMAD3, SMAD2
23fibroblast growth factor receptor signaling pathwayGO:0085439.7CTGF, MAPKAP1, PIK3CA
24endoderm developmentGO:0074929.7TGFB1, SMAD3
25response to glucoseGO:0097499.7SMAD2, TGFB1, CTGF
26regulation of bindingGO:0510989.6TGFB1, SMAD3, SMAD2
27SMAD protein complex assemblyGO:0071839.6TGFB1, SMAD3, SMAD2
28regulation of transforming growth factor beta receptor signaling pathwayGO:0170159.6TGFB1, SMAD3, SMAD2
29negative regulation of cell growthGO:0303089.6CYP27B1, SMAD3, TGFB1
30positive regulation of epithelial to mesenchymal transitionGO:0107189.6TGFB1, SMAD3, SMAD2
31ureteric bud developmentGO:0016579.6SMAD2, SMAD3, TGFB1
32positive regulation of cell migrationGO:0303359.6SMAD3, TGFB1, CCL7
33negative regulation of transforming growth factor beta receptor signaling pathwayGO:0305129.6TGFB1, SMAD3, SMAD2
34platelet degranulationGO:0025769.6F13A1, TIMP1, TGFB1
35response to vitamin DGO:0332809.5SPP1, CYP27B1, TGFB1
36transforming growth factor beta receptor signaling pathwayGO:0071799.5TGFB1, SMAD3, SMAD2
37agingGO:0075689.4TIMP1, DCN, TGFB1, EPO
38protein kinase B signalingGO:0434919.3TGFB1, PIK3CA
39in utero embryonic developmentGO:0017019.3RCN1, SMAD3, SMAD2
40positive regulation of cell proliferationGO:0082849.3CTGF, EPO, TGFB1, TIMP1
41epidermal growth factor receptor signaling pathwayGO:0071739.2MAPKAP1, TGFB1, PIK3CA
42positive regulation of bone mineralizationGO:0305019.2TGFB1, SMAD3
43extracellular matrix organizationGO:0301989.2SPP1, TIMP1, DCN, TGFB1
44platelet activationGO:0301689.1TGFB1, TIMP1, F13A1, PIK3CA
45positive regulation of transcription, DNA-templatedGO:0458939.1SMAD2, SMAD3, TGFB1, EPO
46blood coagulationGO:0075969.0TGFB1, TIMP1, F13A1, PIK3CA
47inflammatory responseGO:0069548.7CCL7, CXCL2, TGFB1, SPP1

Molecular functions related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activityGO:03061810.0SMAD2, SMAD3
2protein-glutamine gamma-glutamyltransferase activityGO:0038109.9TGM2, F13A1
3co-SMAD bindingGO:0704109.9SMAD2, SMAD3
4transforming growth factor beta receptor bindingGO:0051609.8SMAD2, SMAD3
5extracellular matrix bindingGO:0508409.7DCN, SPP1
6protein kinase activator activityGO:0302959.5EPO, PIK3CA
7R-SMAD bindingGO:0704129.5SMAD3, SMAD2
8protein bindingGO:0055156.1CTGF, PIK3CA, SMAD2, SMAD3, TIMP1, TGM2

Products for genes affiliated with Nephrogenic Systemic Fibrosis

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Sources for Nephrogenic Systemic Fibrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet