NFD
MCID: NPH018
MIFTS: 58

Nephrogenic Systemic Fibrosis (NFD) malady

Rare diseases, Skin diseases, Nephrological diseases categories
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Summaries for Nephrogenic Systemic Fibrosis

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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Fully expand this MalaCard
NIH Rare Diseases:43 Nephrogenic systemic fibrosis is a condition that affects different parts of the body, particularly the skin. symptoms of the condition may include progressive swelling and tightening of the skin, sometimes resulting in contractures, and pruritis (itching).  the skin findings are similar to those seen in patients with scleroderma.  nephrogenic systemic fibrosis was first described in 1997. being exposed to gadolinium-containing contrast agents during mri testing has been identified as a significant risk factor for development of this disease. last updated: 4/24/2013

MalaCards: Nephrogenic Systemic Fibrosis, also known as nephrogenic fibrosing dermopathy, is related to keloids and atherosclerosis. An important gene associated with Nephrogenic Systemic Fibrosis is CCL7 (chemokine (C-C motif) ligand 7), and among its related pathways are Signaling by NODAL and Regulation of cytoplasmic and nuclear SMAD2/3 signaling. The compounds tranilast and aristolochic acid have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and eye, and related mouse phenotypes are digestive/alimentary and skeleton.

Wikipedia:65 Nephrogenic systemic fibrosis (NSF) or nephrogenic fibrosing dermopathy is a rare and serious syndrome... more...

Aliases & Classifications for Nephrogenic Systemic Fibrosis

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43NIH Rare Diseases, 49Orphanet, 62UMLS, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases, Nephrological diseases
Orphanet: 49 
Rare skin diseases


Aliases & Descriptions:

nephrogenic systemic fibrosis 43 49
nephrogenic fibrosing dermopathy 43 49 62
nfd 43
nsf 43


External Ids:

SNOMED-CT via Orphanet59 424114000
UMLS via Orphanet63 C1619692

Related Diseases for Nephrogenic Systemic Fibrosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Nephrogenic Systemic Fibrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 99)
idRelated DiseaseScoreTop Affiliating Genes
1keloids30.1SMAD2, SMAD3, F13A1, DCN, TGFB1, CTGF
2atherosclerosis30.0SPP1, F13A1, TIMP1, DCN, TGM2, TGFB1
3kidney disease10.7
4pseudoxanthoma elasticum10.4
5uveitis10.4
6scleromyxedema10.4
7tubulointerstitial nephritis and uveitis10.4
8nephritis10.4
9liver disease10.3
10sarcoma10.3
11neuronal intranuclear inclusion disease10.2
12pure red-cell aplasia10.2
13inflammatory breast carcinoma10.2
14hypercalcemia10.2
15fibrous histiocytoma10.2
16calciphylaxis10.2
17diabetes mellitus10.2
18histiocytoma10.2
19hypothyroidism10.2
20meningitis10.2
21myopathy10.2
22panniculitis10.2
23respiratory failure10.2
24scleroderma10.2
25vasculitis10.2
26spinal cord injury10.2
27endotheliitis10.2
28myelofibrosis10.1TIMP1, EPO
29clear cell adenocarcinoma10.1SMAD3, SMAD2
30lung giant cell carcinoma10.1TIMP1, TGFB1
31localized scleroderma10.1F13A1, DCN
32abdominal aortic aneurysm10.1DCN, TIMP1
33pulmonary disease, chronic obstructive10.0TGFB1, TIMP1
34ureteral obstruction10.0TGFB1, SMAD3
35polycythemia10.0EPO, TIMP1
36proliferative vitreoretinopathy10.0CTGF, TGFB1, TIMP1
37ureteral disease10.0SMAD2, TGFB1, CTGF
38basal cell carcinoma10.0CYP27B1, F13A1, DCN
39rhabdomyosarcoma10.0CTGF, SMAD3, SMAD2
40neuronitis10.0
41retinitis pigmentosa10.0
42botulism10.0
43retinitis10.0
44cork-handlers' disease10.0TGFB1, CCL7, CTGF
45liver cirrhosis10.0CTGF, TGFB1, TIMP1
46malignant fibroxanthoma10.0CTGF, F13A1
47pneumonia10.0TGFB1, CXCL2, CCL7
48secondary hyperparathyroidism of renal origin10.0CYP27B1, EPO
49relapsing-remitting multiple sclerosis10.0TIMP1, SPP1
50cervical cancer10.0PIK3CA, CYP27B1, CCL7

Graphical network of the top 20 diseases related to Nephrogenic Systemic Fibrosis:



Diseases related to nephrogenic systemic fibrosis

Symptoms for Nephrogenic Systemic Fibrosis

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Drugs & Therapeutics for Nephrogenic Systemic Fibrosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Nephrogenic Systemic Fibrosis

Search NIH Clinical Center for Nephrogenic Systemic Fibrosis

Genetic Tests for Nephrogenic Systemic Fibrosis

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Anatomical Context for Nephrogenic Systemic Fibrosis

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33MalaCards
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MalaCards organs/tissues related to Nephrogenic Systemic Fibrosis:

33
Skin, Kidney, Eye, Testes, Liver, Bone, Heart, Breast, Spinal cord, T cells, Endothelial

Animal Models for Nephrogenic Systemic Fibrosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Nephrogenic Systemic Fibrosis:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.7CTGF, TGFB1, DCN, SMAD3, SMAD2
2MP:00053908.6SPP1, CYP27B1, SMAD2, SMAD3, DCN, CTGF
3MP:00053828.6SMAD2, SMAD3, DCN, TGFB1, CTGF
4MP:00053678.4SPP1, CYP27B1, SMAD3, DCN, TGM2, TGFB1
5MP:00053918.4PIK3CA, SMAD2, SMAD3, DCN, TGFB1, CTGF
6MP:00053808.2PIK3CA, SMAD2, SMAD3, TGFB1, EPO, CTGF
7MP:00053798.2PIK3CA, CYP27B1, SMAD2, SMAD3, TIMP1, DCN
8MP:00053888.0SPP1, SMAD2, F13A1, TIMP1, DCN, TGFB1
9MP:00053708.0SPP1, SMAD2, SMAD3, TGFB1, EPO
10MP:00020067.7SPP1, PIK3CA, SMAD2, SMAD3, TIMP1, DCN
11MP:00053867.7SPP1, PIK3CA, SMAD2, SMAD3, DCN, TGM2
12MP:00107717.4SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, DCN
13MP:00053897.3SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, F13A1
14MP:00053877.2SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, TIMP1
15MP:00053787.2SMAD2, CYP27B1, PIK3CA, SPP1, SMAD3, TIMP1
16MP:00053857.0SMAD3, SMAD2, PIK3CA, SPP1, F13A1, TIMP1
17MP:00053977.0CCL7, SPP1, CYP27B1, SMAD2, SMAD3, F13A1
18MP:00053846.8SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, DCN
19MP:00053766.5SMAD3, SMAD2, CYP27B1, PIK3CA, SPP1, F13A1
20MP:00107686.4F13A1, SMAD3, SMAD2, PIK3CA, SPP1, TIMP1

Publications for Nephrogenic Systemic Fibrosis

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52PubMed
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Articles related to Nephrogenic Systemic Fibrosis:

(show top 50)    (show all 381)
idTitleAuthorsYear
1
Substitution of gadolinium ethylenediaminetetraacetate with phosphites: towards gadolinium deposit in nephrogenic systemic fibrosis. (24132302)
2013
2
Nephrogenic systemic fibrosis in denmark- a nationwide investigation. (24349178)
2013
3
Contrast-induced nephropathy and nephrogenic systemic fibrosis: minimizing the risk. (22316507)
2012
4
Understanding nephrogenic systemic fibrosis. (23193473)
2012
5
Quantification of gadolinium in fresh skin and serum samples from patients with nephrogenic systemic fibrosis. (21036418)
2011
6
Nephrogenic systemic fibrosis and gadolinium-containing radiological contrast agents: an update. (21471962)
2011
7
Quantitative assessment of dermal cellularity in nephrogenic systemic fibrosis: a diagnostic aid. (21414498)
2011
8
Nephrogenic systemic fibrosis: a brief review. (21572794)
2011
9
Nephrogenic systemic fibrosis: clinicopathological definition and workup recommendations. (21724294)
2011
10
"Carcinoid-like" tricuspid valvulopathy associated with nephrogenic systemic fibrosis. (21366687)
2011
11
Gadolinium deposition in nephrogenic systemic fibrosis: an examination of tissue using synchrotron x-ray fluorescence spectroscopy. (19896750)
2010
12
Gadolinium-associated nephrogenic systemic fibrosis in patients with renal failure: the need for an interdisciplinary helping network. (20032228)
2010
13
Nephrogenic systemic fibrosis: a review. (20677539)
2010
14
Nephrogenic systemic fibrosis with a spectrum of clinical and histopathological presentation: a disorder of aberrant dermal remodeling. (19341434)
2010
15
Nephrogenic systemic fibrosis in a patient with spinal cord injury: a unique case presentation. (21145526)
2010
16
NFI_B activation and stimulation of chemokine production in normal human macrophages by the gadolinium-based magnetic resonance contrast agent Omniscan: possible role in the pathogenesis of nephrogenic systemic fibrosis. (20959327)
2010
17
MRI safety: nephrogenic systemic fibrosis and other risks. (20542435)
2010
18
Estimates of risk, empirical treatment observations, and unexpected laboratory findings reveal the complexity of nephrogenic systemic fibrosis. (19841408)
2009
19
Nephrogenic systemic fibrosis in patients with chronic kidney disease who received gadopentetate dimeglumine. (19151610)
2009
20
Effects of gadolinium contrast agents in naA^ve and nephrectomized rats: relevance to nephrogenic systemic fibrosis. (19160079)
2009
21
Nephrogenic systemic fibrosis: clinical picture and treatment. (19744598)
2009
22
High-dose gadodiamide for catheter angiography and CT in patients with varying degrees of renal insufficiency: Prevalence of subsequent nephrogenic systemic fibrosis and decline in renal function. (19457816)
2009
23
Nephrogenic systemic fibrosis: incidence, associations, and effect of risk factor assessment--report of 33 cases. (19188312)
2009
24
Involvement of gadolinium chelates in the mechanism of nephrogenic systemic fibrosis: an update. (19744600)
2009
25
Nephrogenic systemic fibrosis and management of high-risk patients. (19375360)
2009
26
Nephrogenic systemic fibrosis in rats treated with erythropoietin and intravenous iron. (19789237)
2009
27
Nephrogenic systemic fibrosis: more questions and some answers. (18688172)
2008
28
Association of gadolinium based magnetic resonance imaging contrast agents and nephrogenic systemic fibrosis. (18635232)
2008
29
Nephrogenic systemic fibrosis: a new concern for rheumatologists. (18756271)
2008
30
An epidemic outbreak of nephrogenic systemic fibrosis in a Danish hospital. (18328659)
2008
31
Cardiac and vascular metal deposition with high mortality in nephrogenic systemic fibrosis. (18401336)
2008
32
Nephrogenic systemic fibrosis and gadolinium: a perfect storm. (18806157)
2008
33
Epoetin and nephrogenic systemic fibrosis. (18158932)
2008
34
Gadolinium-contrast toxicity in patients with kidney disease: nephrotoxicity and nephrogenic systemic fibrosis. (18690983)
2008
35
Nephrogenic systemic fibrosis: chronic imaging findings and review of the medical literature. (18324398)
2008
36
Nephrogenic systemic fibrosis associated with gadolinium use. (18400614)
2008
37
Treatment of nephrogenic systemic fibrosis with Re-PUVA. (18625379)
2008
38
Canadian Association of Radiologists national advisory on gadolinium administration and nephrogenic systemic fibrosis. (19385151)
2008
39
Nephrogenic systemic fibrosis: possible association with a predisposing infection. (18356457)
2008
40
Gadolinium-based contrast agents and their potential role in the pathogenesis of nephrogenic systemic fibrosis: the role of excess ligand. (18425843)
2008
41
Gadolinium-associated nephrogenic systemic fibrosis. (19920874)
2008
42
A timely reminder about an evolving clinical entity: nephrogenic systemic fibrosis and gadolinium use in CKD. (17498132)
2007
43
Treatment with corticosteroids does not seem to benefit nephrogenic systemic fibrosis. (17602192)
2007
44
Safety update on the possible causal relationship between gadolinium-containing MRI agents and nephrogenic systemic fibrosis. (17457808)
2007
45
Long-term retention of gadolinium in tissues from nephrogenic systemic fibrosis patient after multiple gadolinium-enhanced MRI scans: case report and implications. (17712863)
2007
46
Nephrogenic systemic fibrosis associated with gadolinium-containing contrast media administration in patients with reduced glomerular filtration rate. (17504326)
2007
47
The role of the hospital dermatologist in the diagnosis and treatment of calciphylaxis and nephrogenic systemic fibrosis. (18070683)
2007
48
Nephrogenic systemic fibrosis--the beginning of the end? (17572281)
2007
49
Nephrogenic systemic fibrosis/nephrogenic fibrosing dermopathy: clinical aspects. (17215616)
2007
50
Nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis with diaphragmatic involvement in a patient with respiratory failure. (16427988)
2006

Variations for Nephrogenic Systemic Fibrosis

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Expression for genes affiliated with Nephrogenic Systemic Fibrosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephrogenic Systemic Fibrosis

Search GEO for disease gene expression data for Nephrogenic Systemic Fibrosis.

Pathways for genes affiliated with Nephrogenic Systemic Fibrosis

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 60Thomson Reuters, 30KEGG, 54R&D Systems, 5Cell Signaling Technology, 53QIAGEN, 57SinoBiological
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Pathways related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 52)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8SMAD3, SMAD2
29.8SMAD2, SMAD3
3
Show member pathways
Paxillin-independent events mediated by a4b1 and a4b738
a4b1 and a4b7 Integrin signaling38
9.6PIK3CA, EPO
49.6EPO, PIK3CA
59.5SMAD2, TGFB1
69.4SMAD3, CYP27B1, SPP1
79.4EPO, TIMP1, PIK3CA
8
Show member pathways
9.4PIK3CA, SMAD2, SMAD3
99.4SMAD3, SMAD2, PIK3CA
10
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.4PIK3CA, SMAD2, SMAD3
119.2SMAD2, SMAD3, TGFB1
129.2TGFB1, SMAD3, SMAD2
13
Show member pathways
Cell cycle Role of SCF complex in cell cycle regulation60
9.2TGFB1, SMAD3, SMAD2
14
Show member pathways
9.2SMAD2, SMAD3, TGFB1
15
Show member pathways
9.2SMAD2, SMAD3, TGFB1
169.2TGFB1, SMAD3, SMAD2
17
Show member pathways
9.2TGFB1, SMAD3, SMAD2
18
Show member pathways
Cell cycle38
9.2TGFB1, SMAD3, SMAD2
19
Show member pathways
9.2SMAD2, SMAD3, TGFB1
209.2TGFB1, SMAD3, SMAD2
21
Show member pathways
9.2TGFB1, TIMP1, F13A1
22
Show member pathways
9.1TIMP1, TGFB1, CCL7, CTGF
23
Show member pathways
9.1TIMP1, TGM2, TGFB1, CTGF
24
Show member pathways
9.1TGFB1, TGM2, SPP1
259.1TGFB1, SMAD2, PIK3CA
26
Show member pathways
Translation Non genomic rapid action of Androgen Receptor60
9.1PIK3CA, SMAD3, TGFB1
279.0TGFB1, CXCL2
288.9CTGF, TGFB1, SMAD3, SMAD2
298.9SMAD2, SMAD3, TGFB1, CTGF
30
Show member pathways
8.9SMAD2, SMAD3, DCN, TGFB1
318.9SMAD2, SMAD3, DCN, TGFB1
328.8PIK3CA, SMAD2, DCN, TGFB1
33
Show member pathways
8.8SPP1, TIMP1, DCN, TGFB1
34
Show member pathways
8.8CTGF, CCL7, EPO, TGFB1, TIMP1
35
Show member pathways
Signal transduction PTEN pathway60
8.7PIK3CA, SMAD2, SMAD3, TGFB1
368.7PIK3CA, SMAD2, SMAD3, TGFB1
37
Show member pathways
PLK2 and PLK4 events38
Polo-like kinase signaling events in the cell cycle38
8.7PIK3CA, SMAD2, SMAD3, TGFB1
388.7PIK3CA, SMAD2, SMAD3, TGFB1
39
Show member pathways
8.7PIK3CA, SMAD2, SMAD3, TGFB1
40
Show member pathways
8.7TGFB1, SMAD3, SMAD2, PIK3CA
41
Show member pathways
8.7PIK3CA, F13A1, TIMP1, TGFB1
428.7SPP1, SMAD2, SMAD3, TGFB1
43
Show member pathways
8.3TIMP1, TGFB1, CXCL2, CCL7, CTGF
44
Show member pathways
8.3TIMP1, TGFB1, CXCL2, CCL7, CTGF
45
Show member pathways
8.3SPP1, TGFB1, CXCL2, CCL7
46
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.2SPP1, PIK3CA, SMAD2, SMAD3, TGFB1
47
Show member pathways
8.2TIMP1, TGFB1, EPO, CXCL2, CCL7
488.1PIK3CA, SMAD2, SMAD3, DCN, TGFB1, MAPKAP1
49
Show member pathways
7.8SPP1, TIMP1, TGFB1, CXCL2, CCL7, CTGF
50
Show member pathways
6.9SPP1, PIK3CA, SMAD2, SMAD3, TGFB1, CXCL2

Compounds for genes affiliated with Nephrogenic Systemic Fibrosis

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Sources:
45Novoseek, 3BitterDB, 24HMDB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1tranilast459.6TGFB1, SMAD2, TIMP1
2aristolochic acid45 310.5TGFB1, TIMP1, CTGF
3hydroxyproline45 24 1111.4DCN, TGFB1, CTGF, TIMP1
4retinoid459.2CTGF, SPP1, CYP27B1, TIMP1, TGM2
5alginate459.2SPP1, TIMP1, TGFB1, DCN
6lysine459.0DCN, CYP27B1, SMAD2, SMAD3, F13A1, TGM2
7curcumin459.0TIMP1, SPP1, CTGF, CCL7, TGFB1
8genistein45 29 61 3 24 1113.9PIK3CA, DCN, CCL7, SPP1, TIMP1, CYP27B1
9calcitriol45 61 24 1111.8CYP27B1, EPO, SPP1, TGFB1, TIMP1
101,25 dihydroxy vitamin d3458.8CYP27B1, SPP1, TGFB1, SMAD3
11n acetylcysteine458.7SMAD2, CTGF, CXCL2, TIMP1, SMAD3
12ribonucleic acid458.7SPP1, TGFB1, DCN, TIMP1, CCL7, CTGF
13rapamycin458.7EPO, PIK3CA, CTGF, SMAD3, TGM2
14cysteine458.6CTGF, TGM2, DCN, SMAD2, CYP27B1, SPP1
15heparin45 29 24 1111.6SPP1, DCN, PIK3CA, F13A1, TIMP1, CTGF
16butyrate458.5SPP1, SMAD3, TIMP1, EPO, TGFB1
17paraffin458.5DCN, TIMP1, SPP1, TGFB1, CYP27B1, F13A1
18rantes458.5TIMP1, TGFB1, CXCL2, CCL7, MAPKAP1
19vitamin d458.5SPP1, CYP27B1, SMAD3, TIMP1, EPO, TGFB1
20cholesterol45 29 24 1111.4PIK3CA, SPP1, DCN, TIMP1, SMAD3, CYP27B1
21cycloheximide458.4CYP27B1, TIMP1, CTGF, SMAD3, SPP1, TGFB1
22thymidine45 249.4SMAD3, SMAD2, PIK3CA, TGFB1, EPO, CTGF
23fibrinogen458.3TGM2, CXCL2, SPP1, CTGF, F13A1
24hyaluronic acid45 249.3CXCL2, TGFB1, DCN, TIMP1, SPP1
25tgf beta1458.3CTGF, TGFB1, DCN, TIMP1, SMAD3, SPP1
26glucose458.2SPP1, PIK3CA, CYP27B1, SMAD2, SMAD3, DCN
27alanine458.2SMAD2, SPP1, TGFB1, DCN, TGM2, TIMP1
28cyclosporin a45 29 6110.1EPO, TGFB1, DCN, TIMP1, SPP1, PIK3CA
29actinomycin d458.1CCL7, TGFB1, TIMP1, PIK3CA, SPP1
30nitric oxide45 24 1110.1SMAD2, PIK3CA, CXCL2, SMAD3, TIMP1, DCN
31matrigel458.1SMAD2, PIK3CA, TIMP1, DCN, SPP1, TGFB1
32threonine458.0SPP1, CTGF, TGFB1, TGM2, SMAD3, SMAD2
33h2o2458.0PIK3CA, SPP1, TIMP1, CXCL2, CTGF, SMAD2
34retinoic acid45 249.0CTGF, TGM2, TGFB1, DCN, TIMP1, CYP27B1
35bleomycin45 118.9SPP1, EPO, CTGF, TGFB1, DCN, TIMP1
36oxygen45 248.9SPP1, DCN, TGM2, EPO, CXCL2, CCL7
37procollagen457.9TIMP1, TGFB1, CTGF, DCN, F13A1, SMAD3
38pge2457.9CXCL2, TGFB1, CTGF, TIMP1, CYP27B1, SPP1
39sb 20358045 618.8TGFB1, SPP1, SMAD2, SMAD3, TIMP1, CXCL2
40lipid457.6CCL7, CXCL2, CYP27B1, SMAD3, PIK3CA, CTGF
41lactate457.6CTGF, CXCL2, EPO, TGFB1, PIK3CA, TIMP1
42dexamethasone45 51 29 1110.2PIK3CA, SMAD2, DCN, TGFB1, CXCL2, CCL7
43pd 98,059457.0CXCL2, SPP1, PIK3CA, SMAD2, SMAD3, TIMP1
44calcium45 51 24 1110.0CXCL2, CYP27B1, F13A1, TGM2, CTGF, CCL7
45ly294002456.9CTGF, SPP1, PIK3CA, SMAD2, SMAD3, TIMP1
46oligonucleotide456.9DCN, SMAD2, CYP27B1, SPP1, CTGF, CCL7
47tyrosine456.8SPP1, PIK3CA, CYP27B1, TIMP1, EPO, CXCL2
48estrogen456.7TGFB1, DCN, PIK3CA, SPP1, CYP27B1, SMAD3
49serine456.5SMAD3, PIK3CA, SMAD2, SPP1, TIMP1, TGM2
50vegf456.3PIK3CA, SMAD2, SMAD3, F13A1, TIMP1, SPP1

GO Terms for genes affiliated with Nephrogenic Systemic Fibrosis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1SMAD protein complexGO:0711419.8SMAD3, SMAD2
2platelet alpha granule lumenGO:0310938.9TGFB1, TIMP1, F13A1
3extracellular spaceGO:0056157.3SPP1, DCN, TGFB1, EPO, CXCL2, CCL7
4extracellular regionGO:0055766.7CTGF, SPP1, F13A1, TIMP1, DCN, TGFB1

Biological processes related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

(show all 47)
idNameGO IDScoreTop Affiliating Genes
1paraxial mesoderm morphogenesisGO:04834010.2SMAD3, SMAD2
2nodal signaling pathwayGO:03809210.2SMAD2, SMAD3
3primary miRNA processingGO:03105310.2SMAD2, SMAD3
4erythrocyte maturationGO:04324910.2TIMP1, EPO
5pericardium developmentGO:06003910.2SMAD3, SMAD2
6embryonic foregut morphogenesisGO:04861710.2SMAD3, SMAD2
7activin receptor signaling pathwayGO:03292410.1SMAD3, SMAD2
8signal transduction involved in regulation of gene expressionGO:02301910.0SMAD3, SMAD2
9decidualizationGO:04669710.0CYP27B1, SPP1
10embryonic cranial skeleton morphogenesisGO:04870110.0SMAD2, SMAD3
11evasion or tolerance of host defenses by virusGO:0190499.9TGFB1, SMAD3
12response to lipopolysaccharideGO:0324969.9EPO, DCN, CYP27B1
13common-partner SMAD protein phosphorylationGO:0071829.9SMAD2, TGFB1
14response to cholesterolGO:0707239.9TGFB1, SMAD2
15regulation of striated muscle tissue developmentGO:0162029.9TGFB1, SMAD3
16lens fiber cell differentiationGO:0703069.9TGFB1, SMAD3
17developmental growthGO:0485899.9SMAD3, SMAD2
18positive regulation of collagen biosynthetic processGO:0329679.8TGFB1, CTGF
19mesoderm formationGO:0017079.8SMAD2, SMAD3
20negative regulation of mitotic cell cycleGO:0459309.8SMAD3, TGFB1
21extracellular matrix disassemblyGO:0226179.8DCN, TIMP1, SPP1
22transcription initiation from RNA polymerase II promoterGO:0063679.7CTGF, SMAD3, SMAD2
23fibroblast growth factor receptor signaling pathwayGO:0085439.7CTGF, MAPKAP1, PIK3CA
24endoderm developmentGO:0074929.7TGFB1, SMAD3
25response to glucoseGO:0097499.7SMAD2, TGFB1, CTGF
26regulation of bindingGO:0510989.6TGFB1, SMAD3, SMAD2
27SMAD protein complex assemblyGO:0071839.6TGFB1, SMAD3, SMAD2
28regulation of transforming growth factor beta receptor signaling pathwayGO:0170159.6TGFB1, SMAD3, SMAD2
29negative regulation of cell growthGO:0303089.6CYP27B1, SMAD3, TGFB1
30positive regulation of epithelial to mesenchymal transitionGO:0107189.6TGFB1, SMAD3, SMAD2
31ureteric bud developmentGO:0016579.6SMAD2, SMAD3, TGFB1
32positive regulation of cell migrationGO:0303359.6SMAD3, TGFB1, CCL7
33negative regulation of transforming growth factor beta receptor signaling pathwayGO:0305129.6TGFB1, SMAD3, SMAD2
34platelet degranulationGO:0025769.6F13A1, TIMP1, TGFB1
35response to vitamin DGO:0332809.5SPP1, CYP27B1, TGFB1
36transforming growth factor beta receptor signaling pathwayGO:0071799.5TGFB1, SMAD3, SMAD2
37agingGO:0075689.4TIMP1, DCN, TGFB1, EPO
38protein kinase B signalingGO:0434919.3TGFB1, PIK3CA
39in utero embryonic developmentGO:0017019.3RCN1, SMAD3, SMAD2
40positive regulation of cell proliferationGO:0082849.3CTGF, EPO, TGFB1, TIMP1
41epidermal growth factor receptor signaling pathwayGO:0071739.2MAPKAP1, TGFB1, PIK3CA
42positive regulation of bone mineralizationGO:0305019.2TGFB1, SMAD3
43extracellular matrix organizationGO:0301989.2SPP1, TIMP1, DCN, TGFB1
44platelet activationGO:0301689.1TGFB1, TIMP1, F13A1, PIK3CA
45positive regulation of transcription, DNA-templatedGO:0458939.1SMAD2, SMAD3, TGFB1, EPO
46blood coagulationGO:0075969.0TGFB1, TIMP1, F13A1, PIK3CA
47inflammatory responseGO:0069548.7CCL7, CXCL2, TGFB1, SPP1

Molecular functions related to Nephrogenic Systemic Fibrosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activityGO:03061810.0SMAD2, SMAD3
2protein-glutamine gamma-glutamyltransferase activityGO:0038109.9TGM2, F13A1
3co-SMAD bindingGO:0704109.9SMAD2, SMAD3
4transforming growth factor beta receptor bindingGO:0051609.8SMAD2, SMAD3
5extracellular matrix bindingGO:0508409.7DCN, SPP1
6protein kinase activator activityGO:0302959.5EPO, PIK3CA
7R-SMAD bindingGO:0704129.5SMAD3, SMAD2
8protein bindingGO:0055156.1CTGF, PIK3CA, SMAD2, SMAD3, TIMP1, TGM2

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
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37MGI
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41NDF-RT
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