Nephrolithiasis malady

MedlinePlus: A kidney stone is a solid piece of material that forms in the kidney from substances in the urine. it may be as small as a grain of sand or as large as a pearl. most kidney stones pass out of the body without help from a doctor. but sometimes a stone will not go away. it may get stuck in the urinary tract, block the flow of urine and cause great pain. the following may be signs of kidney stones that need a doctor's help: extreme pain in your back or side that will not go away blood in your urine fever and chills vomiting urine that smells bad or looks cloudy a burning feeling when you urinate nih: national institute of diabetes and digestive and kidney diseases²³

MalaCards: Nephrolithiasis, also known as kidney stones, is related to nephritis and interstitial nephritis. An important gene associated with Nephrolithiasis is CLCN5 (chloride channel, voltage-sensitive 5), and among its related pathways are Transport of inorganic cations/anions and amino acids/oligopeptides and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drugs magnesium (as sulfate) and magnesium sulfate and the compounds oxalate and 25-hydroxyvitamin d have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and b cells, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Genetics Home Reference: Cystinuria is a condition characterized by the buildup of cystine crystals or stones in the kidneys and bladder. Cystine is an amino acid, one of the building blocks of proteins. As the kidneys filter blood to create urine, cystine is normally absorbed back into the bloodstream. People with cystinuria cannot properly reabsorb cystine into their bloodstream and the amino acid accumulates in their urine.¹⁷

Wikipedia: A kidney stone, also known as a renal calculus (from the Latin ren, \"kidney\" and calculus, \"pebble\")...⁴⁴ more...

Aliases & Descriptions:

nephrolithiasis 6 7 8 32 43 kidney stones 6 23 calculus of kidney and ureter (disorder) 6 nephrolithiasis, calcium oxalate 6 urolithiasis, calcium oxalate 6

stone - kidney/ureter 6 kidney calculi 43 urolithiasis 43 nephritis 43

Disease types for nephrolithiasis family:

nephrolithiasis, type i

Diseases related to nephrolithiasis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 397)

id	Related Disease	Score	Top Affiliating Genes
1	nephritis	38.3	NAGLU, UMOD, XDH, B2M, FN1, IL1RN
2	interstitial nephritis	34.5	UMOD, APRT
3	urolithiasis	32.5	NAGLU, VDR, UMOD, XDH, MME, IL1B
4	dent disease	31.4	CLCN4, CLCNKB, CLDN16, CLCN5, CLCN7, CLCNKA
5	acute urate nephropathy	31.3	XDH, HPRT1
6	gout	31.2	UMOD, HPRT1, SLC2A9
7	nephrolithiasis/osteoporosis, hypophosphatemic, 2	30.8	BP50, SLC9A3R1
8	adenine phosphoribosyltransferase deficiency	30.3	XDH, APRT, HPRT1
9	nephrocalcinosis	30.3	NAGLU, CLCNKB, CLDN16, CLCN5, CLCN7, KCNJ1
10	primary hyperparathyroidism	30.1	VDR, BGLAP, FGF23, ALPP, CASR, CALCA
11	lesch-nyhan syndrome	30.0	XDH, APRT, HPRT1
12	fanconi syndrome	29.5	NAGLU, CLCN4, CLCN5, AMBP, OCRL
13	primary hyperoxaluria	29.5	NAGLU, B2M, AMBP
14	proteinuria	29.3	NAGLU, VDR, CLCN5, UMOD, B2M, MME
15	hypophosphatemic rickets with hypercalciuria	28.9	FGF23, SLC34A3, SLC34A1
16	bartter syndrome type 3	28.5	CLCNKB, KCNJ1, SLC12A3
17	systemic lupus erythematosus	28.4	NAGLU, VDR, BGLAP, XDH, B2M, INS
18	lupus erythematosus	28.4	NAGLU, VDR, BGLAP, XDH, B2M, INS
19	osteitis fibrosa	28.2	BGLAP, B2M, ALPL, ALPP, ALPPL2, CASR
20	hematuria	28.2	NAGLU, FN1, INS, AMBP
21	hydronephrosis	27.9	NAGLU, B2M, MME, AMBP
22	vasculitis	27.3	FN1, INS, IL1B, IL1RN, F2, HSPG2
23	retinol binding protein	27.2	NAGLU, XDH, B2M, INS, AMBP
24	hypoparathyroidism	27.2	NAGLU, VDR, BGLAP, INS, FGF23, ALPP
25	hypophosphatemia	27.1	VDR, CLCN5, BGLAP, B2M, FGF23, AMBP
26	renal tubular acidosis	27.1	B2M, HSPG2, OCRL, SLC4A1
27	hypomagnesemia	27.0	CLCNKB, CLDN16, BGLAP, INS, CASR, SLC12A3
28	hypercalciuria	26.9	BSND, NAGLU, VDR, CLCNKB, CLDN16, CLCN5
29	glomerulonephritis	26.4	NAGLU, BGLAP, UMOD, XDH, B2M, MME
30	fabry disease	26.3	VDR, BGLAP, UMOD, IL1B
31	hyperparathyroidism	26.2	VDR, BGLAP, KCNJ1, B2M, INS, FGF23
32	nephropathy	26.2	ZNF365, NAGLU, VDR, CLCNKB, UMOD, XDH
33	fibrous dysplasia	26.0	BGLAP, UMOD, FGF23, ALPL, ALPP, ALPPL2
34	nephrotic syndrome	25.9	NAGLU, B2M, INS, IL1B, IL1RN, AMBP
35	primary biliary cirrhosis	25.8	VDR, BGLAP, F2, ALPP, HSPG2, NR1I3
36	end stage renal failure	25.5	BGLAP, UMOD, FN1, INS, IL1RN, PTH
37	rickets	25.3	VDR, BGLAP, INS, FGF23, F2, ALPP
38	pyelonephritis	25.2	NAGLU, UMOD, CHRM3, XDH, B2M, INS
39	crohn's disease	25.0	ZNF365, VDR, BGLAP, XDH, B2M, CDH1
40	insulin resistance	23.8	NAGLU, VDR, BGLAP, INS, IL1B, ALPP
41	amyloidosis	23.8	BGLAP, B2M, MME, INS, IL1B, IL1RN
42	hepatitis c	21.5	VDR, CLDN16, CLDN14, B2M, CDH1, INS
43	rheumatoid arthritis	21.1	NAGLU, VDR, BGLAP, XDH, B2M, MME
44	fibrosis	21.1	NAGLU, VDR, CLC, CLCN3, CLCN4, CLCN5
45	osteoporosis	20.9	VDR, BP50, CLCN7, BGLAP, B2M, INS
46	arthritis	20.5	NAGLU, VDR, BGLAP, UMOD, XDH, B2M
47	hypertension	20.2	BSND, NAGLU, VDR, CLCNKB, CLCNKA, BGLAP
48	diabetes mellitus	19.2	NAGLU, VDR, BGLAP, UMOD, XDH, B2M
49	hepatitis	18.8	NAGLU, VDR, CLC, CLCN4, CLDN16, CLDN14
50	pneumonia	18.8	NAGLU, BGLAP, XDH, B2M, CDH1, MME

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 magnesium (as sulfate), magnesium sulfate

MalaCards organs/tissues related to nephrolithiasis:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Kidney -> Proximal Tubule -> Proximal Tubule Cells	Potential therapeutic candidate, affected by disease

MGI Mouse Phenotypes related to nephrolithiasis:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.7	SLC22A12, PTH, HPRT1, AQP1, XDH, CHRM3
2	hematopoietic system phenotype	MP:0005397	9.4	CASR, HPRT1, PTH, RHD, ORAI1, SLC22A12
3	other phenotype	MP:0005395	9.2	ABCC6, SPP1, CASR, HSPG2, ALPL, FN1
4	liver/biliary system phenotype	MP:0005370	8.6	HPRT1, NR1I3, SLC26A1, SLC13A1, HSPG2, INS
5	integument phenotype	MP:0010771	8.5	HPRT1, ABCC6, OSTM1, ORAI1, SLC4A1, CALCA
6	skeleton phenotype	MP:0005390	7.8	PTH, SPP1, PLAU, OSTM1, SLC34A3, SLC34A1
7	vision/eye phenotype	MP:0005391	7.5	HPRT1, PLAU, ABCC6, OSTM1, ORAI1, OCRL
8	reproductive system phenotype	MP:0005389	7.4	HPRT1, SPP1, NR1I3, OCRL, SLC34A1, SLC13A1
9	immune system phenotype	MP:0005387	7.2	CALCR, HPRT1, PTH, OSTM1, ORAI1, SLC2A9
10	renal/urinary system phenotype	MP:0005367	7.1	CLCN4, CLDN16, CLCN5, CLCN7, CLCNKA, KCNJ1
11	behavior/neurological phenotype	MP:0005386	6.8	CA8, CASR, CALCA, HPRT1, SPP1, OSTM1
12	digestive/alimentary phenotype	MP:0005381	6.6	CASR, HPRT1, PLAU, SLC34A3, SLC26A1, SLC22A12
13	growth/size phenotype	MP:0005378	5.8	OSTM1, PLAU, NR1I3, SPP1, PTH, HPRT1
14	mortality/aging	MP:0010768	5.7	OSTM1, PLAU, NR1I3, PTH, HPRT1, CASR
15	nervous system phenotype	MP:0003631	5.2	ALPL, HSPG2, CALCA, HPRT1, SPP1, PLAU
16	cardiovascular system phenotype	MP:0005385	3.9	SPP1, PTH, HPRT1, CALCA, HSPG2, PLAU
17	homeostasis/metabolism phenotype	MP:0005376	2.1	SLC26A6, SLC12A3, SLC4A1, SLC7A9, SLC13A1, SLC13A2

Articles related to nephrolithiasis:

(show top 50)    (show all 66)

id	Title	Authors	Year	Affiliating Genes
1	A polymorphism of the ORAI1 gene is associated with t he risk and recurrence of calcium nephrolithiasis. (21420116)	Chou Y.H.... Chang W.C.	2011	ORAI1
2	Association of nephrolithiasis and gene for glucose t ransporter type 9 (SLC2A9): study of 145 patients. (20162745)	Polasek O.... Lauc G.	2010	SLC2A9
3	Association between the T-593A and C6982T polymorphis ms of the osteopontin gene and risk of developing nephrolithiasis. (21044748)	GAPgebakan B.... DemiryA1rek A.T.	2010	SPP1
4	Hypophosphatemic rickets with hypercalciuria due to m utation in SLC34A3/type IIc sodium-phosphate cotransporter: presentation as hyp ercalciuria and nephrolithiasis. (19820004)	Tencza A.L.... Levine M.A.	2009	SLC34A3
5	Heparan sulfate gene polymorphism in calcium oxalate nephrolithiasis. (19066875)	Onaran M.... BozkA+rlA+ I.	2009	HSPG2
6	Patients with nephrolithiasis and blood hypertension have higher calciuria than those with isolated nephrolithiasis or hypertension? (19417722)	Schleicher M.M.... Casulari L.A.	2009	INS
7	A HindIII polymorphism of fibronectin gene is associa ted with nephrolithiasis. (19616291)	Onaran M.... Bozkirli I.	2009	FN1
8	Species differences in Cl- affinity and in electrogenicity of SLC26A6-mediated oxalate/Cl- exchange correlate with the distinct human and mouse susceptibilities to nephrolithiasis. (18174209)	Clark J.S.... Alper S.L.	2008	SLC26A6
9	Genetics of hypercalciuric nephrolithiasis: renal stone disease. (17872384)	Stechman M.J.... Thakker R.V.	2007	KCNJ1, CLDN16, CLCNKB
10	2,8-dihydroxyadenine nephrolithiasis: from diagnosis to therapy (18039602)	Bouzidi H.... Daudon M.	2007	APRT, XDH
11	Urinary 8-hydroxydeoxyguanosine is elevated in patien ts with nephrolithiasis. (17541572)	Boonla C.... Tosukhowong P.	2007	NAGLU
12	Randall's plaque, calcium-sensing receptor, and idiopathic calcium nephrolithiasis. (17167508)	Abaterusso C.... Gambaro G.	2007	CASR
13	An unusual patient with hypercalciuria, recurrent nephrolithiasis, hypomagnesemia and G227R mutation of Paracellin-1. An unusual patient with hypercalciuria and hypomagnesemia unresponsive to thiazide diuretics. (16804318)	Kutluturk F.... Ozbey N.	2006	CLDN16
14	Renal prothrombin mRNA is significantly decreased in a hyperoxaluric rat model of nephrolithiasis. (16981243)	Grover P.K.... Ryall R.L.	2006	F2
15	Association of urokinase gene 3'-UTR polymorphism with calcium oxalate nephrolithiasis. (16509805)	Mittal R.D.... Bhandari M.	2006	PLAU
16	Emergence of talanin protein associated with human uric acid nephrolithiasis in the hominidae lineage. (15363853)	Gianfrancesco F.... Parastu M.	2004	ZNF365
17	Sodium-phosphate cotransporters, nephrolithiasis and bone demineralization. (15483460)	Prie D.... Silve C.	2004	FGF23, SLC34A1
18	The relationship of 3' vitamin D receptor haplotypes to urinary supersaturation of calcium oxalate salts and to age at onset and familial prevalence of nephrolithiasis. (15213319)	Mossetti G.... Nunziata V.	2004	VDR
19	The metabolic syndrome and uric acid nephrolithiasis: novel features of renal manifestation of insulin resistance. (14717908)	Abate N.... Sakhaee K.	2004	INS
20	Hospitalized nephrolithiasis after renal transplantation in the United States. (12694070)	Abbott K.C.... Agodoa L.Y.	2003	MME
21	Polymorphisms in the vitamin D receptor gene and the risk of calcium nephrolithiasis in children. (12814692)	Ozkaya O.... Hasanoglu E.	2003	VDR
22	Dent's disease: hereditary nephrolithiasis related to defective tubular endocytosis processes (14732909)	Tosetto E.... Gambaro G.	2003	CLCN5
23	Identification of a novel gene and a common variant associated with uric acid nephrolithiasis in a Sardinian genetic isolate. (12740763)	Gianfrancesco F.... Pirastu M.	2003	ZNF365
24	Bartter syndrome type 3: an unusual cause of nephrolithiasis. (11865110)	Colussi G.... Civati G.	2002	CLCNKB
25	Identification of a new candidate locus for uric acid nephrolithiasis. (11309680)	Ombra M.N.... Pirastu M.	2001	ZNF365
26	Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis. (11115837)	Wang S.S.... Guggino W.B.	2000	CLCN5
27	Pathogenesis of Dent's disease and related syndromes of X-linked nephrolithiasis. (10720930)	Thakker R.V.	2000	CLCN5
28	Evaluation of the calcium-sensing receptor gene in idiopathic hypercalciuria and calcium nephrolithiasis. (10886547)	Petrucci M.... Bonnardeaux A.	2000	CASR, NR1I3
29	Characterization of novel promoter and enhancer elements of the mouse homologue of the Dent disease gene, CLCN5, implicated in X-linked hereditary nephrolithiasis. (10373326)	Tanaka K.... Craig I.W.	1999	CLCN5, CLCNKA
30	Association between vitamin D receptor gene polymorphism and nephrolithiasis. (10436404)	Ruggiero M.... Chiarugi V.	1999	VDR
31	X-linked recessive nephrolithiasis: presentation and diagnosis in children. (9602200)	Schurman S.J.... Scheinman S.J.	1998	CLCN5
32	CLCN5 chloride-channel mutations in six new North American families with X-linked nephrolithiasis. (9734595)	Hoopes R.R.... Scheinman S.J.	1998	CLCN5
33	Cystinuria subtype and the risk of nephrolithiasis. (9648063)	Goodyer P.... Rozen R.	1998	SLC3A1
34	Clinical features of X-linked nephrolithiasis in childhood. (9811383)	Langlois V.... Goodyer P.R.	1998	CLCN5
35	Calciotropic hormones and nephrolithiasis. (9387131)	D'Angelo A.... Giannini S.	1997	CALCA
36	Characterisation of renal chloride channel, CLCN5, mutations in hypercalciuric nephrolithiasis (kidney stones) disorders. (9259268)	Lloyd S.E.... Thakker R.V.	1997	CLCN5
37	Interaction of urinary crystals with renal epithelial cells in the pathogenesis of nephrolithiasis. (8890401)	Lieske J.C.... Toback F.G.	1996	SPP1
38	Role of calcium oxalate monohydrate crystal interacti ons with renal epithelial cells in the pathogenesis of nephrolithiasis: a revie w. (9813629)	Lieske J.C.... Toback F.G.	1996	SPP1
39	Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis. (8643571)	Engle S.J.... Tischfield J.A.	1996	APRT
40	Characterization of carrier females and affected males with X-linked recessive nephrolithiasis. (7703383)	Reinhart S.C.... Scheinman S.J.	1995	B2M, AMBP
41	Cloning and characterization of CLCN5, the human kidney chloride channel gene implicated in Dent disease (an X-linked hereditary nephrolithiasis). (8575751)	Fisher S.E.... Craig I.W.	1995	CLCN5
42	Tamm-Horsfall glycoprotein and calcium nephrolithiasis. (7783702)	Hess B.	1994	UMOD
43	Pathogenesis and management of hypercalciuric nephrolithiasis. (7783695)	Breslau N.A.	1994	VDR
44	Isolation and partial characterization of a chloride channel gene which is expressed in kidney and is a candidate for Dent's disease (an X-linked hereditary nephrolithiasis). (7874126)	Fisher S.... Craig I.W.	1994	CLCN5
45	Uric acid nephrolithiasis. (7783706)	Halabe A.... Sperling O.	1994	HPRT1
46	Mapping the gene causing X-linked recessive nephrolithiasis to Xp11.22 by linkage studies. (8099916)	Scheinman S.J.... Thakker R.V.	1993	CLCN5
47	Adenine phosphoribosyltransferase deficiency with renal deposition of 2,8-dihydroxyadenine leading to nephrolithiasis and chronic renal failure. (8447714)	Fye K.H.... Tischfield J.A.	1993	APRT
48	Correction of erythrocyte abnormalities in idiopathic calcium-oxalate nephrolithiasis and reduction of urinary oxalate by oral glyco saminoglycans. (1678082)	Baggio B.... Borsatti A.	1991	RHD
49	Molecular abnormality of Tamm-Horsfall glycoprotein in calcium oxalate nephrolithiasis. (2012207)	Hess B.... Coe F.L.	1991	UMOD
50	X-linked recessive nephrolithiasis with renal failure. (1908057)	Frymoyer P.A.... Schroeder E.T.	1991	CA8

Genes related to nephrolithiasis according to GeneCards:

(show top 50)    (show all 77)

id	Symbol	Description	Score	GeneCards Section Context
1	CLCN5	chloride channel, voltage-sensitive 5	11.1	Summaries, Aliases & Descriptions, Publications
2	SLC9A3R1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	11.1	Summaries
3	ZNF365	zinc finger protein 365	11.1	Summaries, Publications, UniProt Related
4	SLC34A1	solute carrier family 34 (sodium phosphate), member 1	11.1	Summaries, Publications
5	BP50	Blood pressure QTL 50	11.0
6	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.0	Publications
7	XDH	xanthine dehydrogenase	11.0	Publications
8	SLC34A3	solute carrier family 34 (sodium phosphate), member 3	11.0	Publications
9	CLCNKB	chloride channel, voltage-sensitive Kb	11.0	Publications
10	CLDN16	claudin 16	11.0	Publications
11	APRT	adenine phosphoribosyltransferase	11.0	Publications
12	AGXT	alanine-glyoxylate aminotransferase	11.0	Publications
13	SLC3A1	solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1	11.0	Publications
14	FGF23	fibroblast growth factor 23	11.0	Publications
15	UMOD	uromodulin	11.0	Publications
16	NR1I3	nuclear receptor subfamily 1, group I, member 3	11.0	Publications
17	RHD	Rh blood group, D antigen	11.0	Publications
18	SPP1	secreted phosphoprotein 1	11.0	Publications
19	VDR	vitamin D (1,25- dihydroxyvitamin D3) receptor	11.0	Publications
20	CASR	calcium-sensing receptor	11.0	Publications
21	PTH	parathyroid hormone	11.0
22	PFN3	profilin 3	11.0
23	GRHPR	glyoxylate reductase/hydroxypyruvate reductase	11.0	Publications
24	BSND	Bartter syndrome, infantile, with sensorineural deafness (Barttin)	11.0	Publications
25	SLC26A6	solute carrier family 26, member 6	11.0	Publications
26	RCCD1	RCC1 domain containing 1	11.0	Disorders
27	CLCNKA	chloride channel, voltage-sensitive Ka	11.0	Publications
28	HOGA1	4-hydroxy-2-oxoglutarate aldolase 1	11.0
29	SLC26A10	solute carrier family 26, member 10	11.0
30	SLC26A1	solute carrier family 26 (sulfate transporter), member 1	11.0
31	CLC	Charcot-Leyden crystal protein	11.0
32	PREPL	prolyl endopeptidase-like	11.0
33	ORAI1	ORAI calcium release-activated calcium modulator 1	11.0	Publications
34	SLC22A12	solute carrier family 22 (organic anion/urate transporter), member 12	11.0
35	SIK1	salt-inducible kinase 1	11.0
36	OR2B2	olfactory receptor, family 2, subfamily B, member 2	11.0	Disorders
37	EMP1	epithelial membrane protein 1	11.0
38	SLC13A2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	11.0
39	HAO2	hydroxyacid oxidase 2 (long chain)	11.0
40	OSTM1	osteopetrosis associated transmembrane protein 1	11.0
41	KCNJ1	potassium inwardly-rectifying channel, subfamily J, member 1	11.0	Publications
42	GGCX	gamma-glutamyl carboxylase	11.0
43	ALPPL2	alkaline phosphatase, placental-like 2	11.0
44	OCRL	oculocerebrorenal syndrome of Lowe	11.0
45	CLCN7	chloride channel, voltage-sensitive 7	11.0
46	CLCN4	chloride channel, voltage-sensitive 4	11.0
47	SLC7A9	solute carrier family 7 (glycoprotein-associated amino acid transporter light chain, bo,+ system), member 9	11.0
48	SLC13A1	solute carrier family 13 (sodium/sulfate symporters), member 1	11.0
49	SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	11.0
50	CA8	carbonic anhydrase VIII	11.0	Publications

Pathways related to nephrolithiasis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Transport of inorganic cations/anions and amino acids/oligopeptides38	10.3	SLC34A3, SLC34A1, SLC26A1, SLC26A6
2	Development_Hedgehog and PTH signaling pathways in bone and cartilage development41	10.1	VDR, BGLAP, PTH, SPP1
3	Hepatic ABC Transporters36	10.0	CLCNKA, CLCN7, CLCN5, CLCNKB, CLCN4, CLCN3
4	Development Hedgehog and PTH signaling pathways in bone and cartilage development10	10.0	SPP1, PTH, BGLAP, VDR
5	Folate biosynthesis20	9.8	ALPL, ALPP, ALPPL2
6	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.2	VDR, SPP1, PTH, CALCA, CALCR, IL1B
7	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.1	SPP1, PTH, CALCA, CALCR, IL1B, BGLAP
8	Warfarin Pathway, Pharmacodynamics34	8.9	GGCX, F2, BGLAP

Compounds related to nephrolithiasis according to GeneDecks:

(show top 50)    (show all 170)

id	Compound	Score	Top Affiliating Genes
1	oxalate32	10.3	UMOD, SLC26A1, NAGLU, GRHPR, SPP1, RHD
2	25-hydroxyvitamin d32	10.0	ALPP, SPP1, PTH, CASR, FGF23, BGLAP
3	dmsa32	9.8	CALCA, AMBP, B2M, NAGLU, VDR
4	citrate32	9.7	VDR, SLC13A2, UMOD, NAGLU, MME, SLC4A1
5	pamidronate32 9 9	11.6	ALPP, B2M, PTH, CALCA, CASR, BGLAP
6	calcium carbonate32	9.5	BGLAP, B2M, CALCA, ALPP, PTH
7	1,25 dihydroxy vitamin d332	9.5	NR1I3, SPP1, PTH, BGLAP, FGF23, ALPP
8	uric acid32 18	10.5	B2M, SLC22A12, SPP1, HPRT1, AMBP, NAGLU
9	chlorine32 18	10.4	B2M, BSND, CLCN3, CLCN4, CLCNKB, CLCN5
10	24,25-dihydroxyvitamin d332	9.4	BGLAP, ALPP, CALCA, ADCY10, VDR
11	thiazide32	9.4	CASR, SLC12A3, VDR, INS, BGLAP, CALCA
12	furosemide32 42 34 9 18 9	14.4	NAGLU, BSND, SLC12A3, CALCA, MME, SLC4A1
13	potassium32 9 18 9	12.3	AMBP, PTH, SLC12A3, SLC4A1, CLCNKB, CLCNKA
14	bicarbonate32	9.3	SLC26A1, PTH, RHD, AQP1, CA8, CDH1
15	nacl32	9.3	SLC12A3, UMOD, CASR, IL1RN, FN1, KCNJ1
16	phosphorus32	9.2	NAGLU, VDR, BGLAP, B2M, FGF23, ALPP
17	calcium oxalate32	9.2	NAGLU, UMOD, FN1, APRT, AMBP, F2
18	magnesium32 9 18 9	12.1	CLCNKA, SIK1, ALPPL2, NR1I3, PTH, HPRT1
19	ascorbic acid32 18	10.0	BGLAP, MME, ALPP, HSPG2, HPRT1, SPP1
20	hydroxyapatite32	8.9	CASR, SPP1, ALPL, AMBP, FGF23, FN1
21	hyaluronic acid32 18	9.9	CDH1, FN1, F2, B2M
22	aprotinin32 9 9	10.8	F2, PLAU, ITIH4, FN1, NAGLU, AMBP
23	sodium32 18	9.7	NR1I3, PTH, CASR, AMBP, AQP1, MME
24	nifedipine32 9 9	10.7	ITIH4, BGLAP, NAGLU, B2M, AMBP, ALPP
25	fluoride32	8.7	SPP1, BGLAP, ADCY10, HSPG2, ALPP, B2M
26	latex32	8.5	ALPP, SPP1, RHD, FN1, AMBP, CDH1
27	chloride32	8.3	BSND, CLC, CLCN3, FN1, AQP1, CASR
28	pge232	8.0	SPP1, PLAU, CASR, ADCY10, HSPG2, MME
29	h2o232	7.8	FN1, HAO1, RHD, PLAU, SPP1, HPRT1
30	cisplatin32 34 9 9	10.8	NAGLU, XDH, B2M, BGLAP, CDH1, FN1
31	ibmx32	7.8	ALPP, PTH, IL1B, INS, ADCY10, FN1
32	vitamin d32	7.4	NAGLU, SLC34A1, SLC13A1, NR1I3, SPP1, PTH
33	pge132	7.3	F2, B2M, IL1RN, ALPP, HSPG2, PLAU
34	cysteine32	7.2	GGCX, HAO1, SLC4A1, SLC13A2, SLC3A1, BGLAP
35	adenylate32	7.1	PTH, VDR, APRT, HSPG2, CALCR, CASR
36	glutamate32	7.1	CDH1, VDR, ALPP, CALCA, HPRT1, SPP1
37	arginine32	7.1	FN1, INS, FGF23, AQP1, ALPP, CASR
38	cycloheximide32	7.1	IL1RN, FN1, ADCY10, MME, ALPP, HSPG2
39	calcitriol32 42 9 18 9	11.0	SLC34A1, PLAU, NR1I3, SPP1, PTH, CALCA
40	aspartate32	6.8	NAGLU, F2, PLAU, RHD, AGXT, SLC9A3R1
41	indomethacin32 9 9	8.7	ADCY10, IL1RN, B2M, CDH1, ITIH4, MME
42	cyclosporin a32 42	7.7	CALCR, CASR, CALCA, AMBP, NR1I3, ALPP
43	heparin32 9 18 9	9.6	FN1, ITIH4, CDH1, CHRM3, UMOD, BGLAP
44	dexamethasone32 42 34 9 9	10.3	ADCY10, IL1RN, NR1I3, VDR, SPP1, CDH1
45	estrogen32	5.9	INS, PLAU, SLC9A3R1, NR1I3, SPP1, B2M
46	lactate32	5.9	SPP1, PLAU, SLC4A1, XDH, NAGLU, HAO1
47	creatinine32	5.3	NAGLU, ALPP, CALCR, CASR, CALCA, HPRT1
48	serine32	5.3	ALPP, SLC9A3R1, SLC12A3, SLC3A1, RHD, F2
49	alanine32	5.0	SPP1, CASR, CALCR, HSPG2, ALPP, F2
50	calcium32 9 18 9	8.0	CLCN3, VDR, NAGLU, BSND, CLDN16, CLCNKB

Cellular components related to nephrolithiasis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	brush border membrane	GO:031526	10.1	SLC9A3R1, SLC22A12, SLC34A1, SLC34A3, AQP1
2	basolateral plasma membrane	GO:016323	9.7	BSND, UMOD, CHRM3, AQP1, SLC34A1, SLC4A1
3	apical plasma membrane	GO:016324	9.5	SLC9A3R1, SLC12A3, SLC22A12, SLC34A3, ABCC6, AQP1
4	apical part of cell	GO:045177	9.1	ADCY10, SPP1, AQP1, CDH1, CLCN5
5	integral to plasma membrane	GO:005887	8.5	ORAI1, SLC2A9, SLC34A1, SLC3A1, SLC12A3, SLC4A1
6	extracellular space	GO:005615	6.1	ALPL, HSPG2, CALCA, PTH, SPP1, PLAU
7	plasma membrane	GO:005886	3.6	ADCY10, ABCC6, OR2B2, SLC34A3, SLC2A9, SLC34A1

Biological processes related to nephrolithiasis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular phosphate ion homeostasis	GO:030643	10.4	FGF23, SLC34A3, SLC9A3R1
2	excretion	GO:007588	10.3	CLCNKB, GRHPR, UMOD, KCNJ1, CLCNKA, CLCN5
3	glyoxylate metabolic process	GO:046487	10.2	HAO1, AGXT, HOGA1, GRHPR
4	ion transport	GO:006811	9.9	SLC7A9, SLC4A1, SLC12A3, SLC26A6, SLC3A1, SLC26A1
5	transport	GO:006810	9.4	SLC13A2, SLC7A9, SLC12A3, ABCC6, CLCNKA, CLCN7
6	transmembrane transport	GO:055085	9.2	SLC26A6, SLC12A3, SLC4A1, SLC7A9, SLC13A1, SLC13A2
7	response to vitamin D	GO:033280	9.1	SPP1, ALPL, IL1B, BGLAP
8	response to glucocorticoid stimulus	GO:051384	8.7	AGXT, CALCR, ALPL, IL1RN, IL1B, BGLAP
9	acute-phase response	GO:006953	8.2	F2, IL1RN, INS, FN1, ITIH4

Molecular functions related to nephrolithiasis according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	medium-chain-(S)-2-hydroxy-acid oxidase activity	GO:052854	10.2	HAO1, HAO2
2	(S)-2-hydroxy-acid oxidase activity	GO:003973	10.2	HAO2, HAO1
3	antiporter activity	GO:015297	10.1	SLC26A10, CLCN7, CLCN5, CLCN4, CLCN3
4	voltage-gated chloride channel activity	GO:005247	10.1	CLCN3, CLCN4, CLCNKB, CLCN5, CLCN7, CLCNKA
5	long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity	GO:052853	10.1	HAO2, HAO1
6	alkaline phosphatase activity	GO:004035	10.0	ALPPL2, ALPP, ALPL
7	chloride channel activity	GO:005254	10.0	BSND, CLCN3, CLCN4, CLCN5, CLCN7
8	very-long-chain-(S)-2-hydroxy-acid oxidase activity	GO:052852	9.9	HAO2, HAO1