Nephropathy malady

Wikipedia: Nephropathy means damage to or disease of a kidney. Nephrosis is non-inflammatory nephropathy. Nephritis...⁴⁴ more...

MalaCards: Nephropathy, also known as kidney diseases, is related to carcinoma and prostatitis. An important gene associated with Nephropathy is ACE (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1), and among its related pathways are Rho Family GTPases and Transendothelial Migration of Leukocytes. The drugs albumin,human and dopamine and the compounds cholesterol and sucrose have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are mortality/aging and cellular.

nephropathy 7 kidney diseases 43

Diseases related to nephropathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1064)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	99.0	PIGR, LRP1, LRP2, LRPAP1, PDCD1, REG1A
2	prostatitis	86.1	LRP1, LRP2, PDCD1, RELA, RETN, SGK1
3	pancreatitis	85.8	LRG1, LRP1, LRP2, NCALD, REG1A, RELA
4	hypertension	85.4	LRG1, LRP1, COG2, RFH1, REN, RENBP
5	diabetes mellitus	84.8	COG2, PDCD1, REG1A, REN, RETN, SGK1
6	fibrosis	80.0	LRG1, LRP1, REG1A, RELA, REN, RETN
7	atherosclerosis	77.1	LRP1, LRP2, LRPAP1, COG2, PDCD1, REG1A
8	cholesterol	76.1	LRP1, LRP2, LRPAP1, COG2, REG1A, RELA
9	rheumatoid arthritis	75.2	LRP1, LRP2, PDCD1, RELA, RETN, CNDP2
10	thyroiditis	71.6	LRP1, LRP2, LRPAP1, COG2, RELA, REN
11	cerebritis	69.5	LRP1, LRP2, COG2, REG1A, RELA, REN
12	obesity	68.7	LRP1, COG2, RELA, REN, RETN, SGK1
13	insulin resistance	67.6	LRP1, COG2, RELA, REN, RETN, SGK1
14	hypoxia	67.2	LRP1, RELA, REN, KITLG, VWF, VTN
15	myocardial infarction	65.7	LRP1, LRPAP1, COG2, PDCD1, REN, RETN
16	ischemia	64.4	COG2, RELA, REN, RETN, SGK1, KITLG
17	proteinuria	63.4	LRP2, COG2, REN, RENBP, KIRREL, VWF
18	peritonitis	63.1	LRG1, LRP1, LRPAP1, COG2, REG1A, RELA
19	glomerulonephritis	62.8	PIGN, LRP1, LRP2, LRPAP1, REN, SGK1
20	retinitis	62.5	LRP1, LRP2, LRPAP1, NCALD, SGK1, KITLG
21	lupus erythematosus	59.3	LRP2, COG2, PDCD1, RETN, VWF, VTN
22	myeloma	58.3	LRP1, LRP2, RELA, SGK1, KITLG, VWF
23	coronary heart disease	56.8	LRP1, COG2, RETN, CNDP1, VWF, GCG
24	anemia	56.3	PDCD1, RELA, REN, SGK1, KITLG, VWF
25	hyperglycemia	55.8	COG2, RETN, SGK1, CNDP1, VWF, VTN
26	diabetic retinopathy	55.2	KITLG, VWF, VTN, RBP4, SELE, SELL
27	nephritis	54.4	LRP2, LRPAP1, PDCD1, REN, VWF, VTN
28	essential hypertension	54.2	COG2, REN, RENBP, RETN, SGK1, VWF
29	cystic fibrosis	53.1	REG1A, REN, SGK1, VWF, PCNA, RBP4
30	type 2 diabetes mellitus	53.0	COG2, RETN, SGK1, VWF, PCSK1, GCK
31	nephrotic syndrome	50.9	LRP2, RELA, REN, RETN, KITLG, KIRREL
32	aldosteronism	50.5	REN, RENBP, RETN, SGK1, GCH1, SERPINE1
33	blindness	50.4	COG2, REN, VWF, GCG, RBP4, SELE
34	thrombosis	49.8	LRP1, LRPAP1, COG2, REN, RETN, VWF
35	multiple myeloma	49.6	LRP1, RELA, KITLG, VWF, VTN, PCNA
36	homocysteine	48.5	COG2, RELA, REN, RETN, VWF, PCNA
37	neuropathy	48.4	REN, RETN, VWF, GCG, SELE, SERPINF1
38	hyperlipidemia	47.9	LRP1, COG2, RETN, VWF, GCK, RBP4
39	adenocarcinoma	47.6	PIGR, LRG1, LRP1, REG1A, RELA, KITLG
40	gonococcal synovitis	47.2	PIGR, LRP1, PDCD1, REG1A, RELA, RETN
41	neuronitis	47.2	LRP1, LRP2, LRPAP1, NCALD, REG1A, RELA
42	leukemia	47.0	LRP1, LRPAP1, COG2, PDCD1, RELA, REN
43	aortic aneurysm	46.6	REN, RETN, VWF, SELE, SELL, SERPINE1
44	type 1 diabetes mellitus	45.8	PDCD1, RETN, GCK, GCG, RBP4, NAGLU
45	hypercholesterolemia	45.8	LRP1, COG2, RETN, VWF, GCG, RBP4
46	iga glomerulonephritis	45.7	PIGR, VTN, SELE, SELL, SERPINB7, SERPINA1
47	purpura	45.6	VWF, SELE, SELP, SERPINE1, VEGFA, VCAM1
48	vascular disease	45.4	LRP1, RETN, VWF, VTN, SELE, SELP
49	hepatocellular carcinoma	45.1	PIGR, PDCD1, REG1A, RELA, CNDP1, CNDP2
50	thyroid carcinoma	44.5	KITLG, PCNA, RB1, SELE, SELL, SERPINB13

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 albumin,human, albumin,human inj [va product], dopamine, dopamine hydrochloride

MalaCards organs/tissues related to nephropathy:

²²

MGI Mouse Phenotypes related to nephropathy:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	INF	LRRC7, LRP1, , PDCD1, RELA, REN
2	cellular phenotype	MP:0005384	INF	LRP2, PDCD1, RELA, KITLG, KIF3A, VWF
3	growth/size phenotype	MP:0005378	INF	LRRC7, LRP1, LRP2, RELA, REN, SGK1
4	normal phenotype	MP:0002873	INF	LRP1, , RELA, REN, VTN, GCM1
5	hematopoietic system phenotype	MP:0005397	INF	PIGR, PDCD1, PCNA, PCSK1, SERPINB2, MYD88
6	endocrine/exocrine gland phenotype	MP:0005379	INF	LRP2, , REG1A, PCSK1, SELL, BMPR1A
7	behavior/neurological phenotype	MP:0005386	INF	LRRC7, LRP1, LRP2, REN, KIF3A, PCSK1N
8	skeleton phenotype	MP:0005390	INF	LRP1, LRP2, RELA, KITLG, KIF3A, RB1
9	homeostasis/metabolism phenotype	MP:0005376	INF	PIGR, LRP1, LRP2, , REG1A, RELA
10	immune system phenotype	MP:0005387	INF	PIGR, LRP1, REN, VWF, PCSK1, SELL
11	vision/eye phenotype	MP:0005391	22.9	LRP2, PDCD1, RELA, KITLG, KIF3A, RB1
12	adipose tissue phenotype	MP:0005375	18.9	LRP1, RETN, PCSK1, RB1, SERPINE1, LPL
13	limbs/digits/tail phenotype	MP:0005371	16.0	RELA, KITLG, KIF3A, RB1, VEGFA, VDR
14	hearing/vestibular/ear phenotype	MP:0005377	14.4	LRP2, KITLG, RB1, NAGLU, VDR, LMNA
15	respiratory system phenotype	MP:0005388	14.3	LRP2, KIF3A, SELL, SELP, LPL, BMPR1A
16	pigmentation phenotype	MP:0001186	13.6	KITLG, RB1, SERPINF1, NAGLU, LMNA, BMP7
17	embryogenesis phenotype	MP:0005380	11.1	KIF3A, BBS7, OFD1
18	muscle phenotype	MP:0005369	INF	LRP1, PDCD1, RELA, REN, PCSK1, RB1
19	integument phenotype	MP:0010771	INF	RELA, KITLG, RB1, SELP, LMX1B, ZMIZ1
20	craniofacial phenotype	MP:0005382	INF	LRP2, KITLG, KIF3A, NAGLU, LMX1B, BMP4
21	reproductive system phenotype	MP:0005389	INF	PIGR, , REG1A, REN, PCSK1, RBP4
22	cardiovascular system phenotype	MP:0005385	INF	LRP1, PDCD1, RELA, REN, KITLG, KIF3A
23	tumorigenesis	MP:0002006	INF	KITLG, RB1, SELL, SERPINE1, MYD88, BMPR1A
24	renal/urinary system phenotype	MP:0005367	INF	LRP2, , PDCD1, REN, RENBP, SGK1
25	digestive/alimentary phenotype	MP:0005381	INF	PIGR, LRP2, KITLG, KIF3A, VWF, PCSK1
26	liver/biliary system phenotype	MP:0005370	INF	RETN, GCK, VEGFA, LPL, BMP4, LIF
27	nervous system phenotype	MP:0003631	INF	LRRC7, LRP1, , PDCD1, RELA, REN
28	other phenotype	MP:0005395	INF	, SERPINH1, RARA, CLU, KDR, LAMA4
29	no phenotypic analysis	MP:0003012	INF	LRRC7, LRP2, SGK1, PCNA, RB1, VEGFA

Articles related to nephropathy:

(show top 50)    (show all 2457)

id	Title	Authors	Year	Affiliating Genes
1	APOL1 genetic variants in focal segmental glomerulosc lerosis and HIV-associated nephropathy. (21997394)	Kopp J.B.... Winkler C.A.	2011	APOL1
2	Common genetic variants in the chromogranin a promote r are associated with renal injury in IgA nephropathy patients with malignant h ypertension. (20113265)	Yu L.... Zhang H.	2010	CHGA
3	Association of polymorphisms within the transforming growth factor-I^1 gene with diabetic nephropathy and serum cholesterol and trigl yceride concentrations. (20883286)	Valladares-Salgado A.... Cruz M.	2010	TGFB1
4	Cellular basis of diabetic nephropathy: V. Endoglin e xpression levels and diabetic nephropathy risk in patients with Type 1 diabetes . (19395281)	Alvarez-MuA+oz P.... Caramori M.L.	2010	ENG
5	Gene-gene and gene-environment interactions in HIV-as sociated nephropathy: A focus on the MYH9 nephropathy susceptibility gene. (20005488)	NA_A+ez M.... Freedman B.I.	2010	MYH9
6	Sulodexide ameliorates early but not late kidney dise ase in models of radiation nephropathy and diabetic nephropathy. (20061322)	Rossini M.... Fogo A.B.	2010	SERPINE1, CD36
7	The biochemical pharmacology of renin inhibitors: imp lications for translational medicine in hypertension, diabetic nephropathy and heart failure: expectations and reality. (19477166)	Abassi Z.... Feuerstein G.Z.	2009	REN, ATP6AP2
8	Levels of urinary complement factor H in patients wit h IgA nephropathy are closely associated with disease activity. (19508377)	Zhang J.J.... Zhao M.H.	2009	CFH
9	No evidence for a role of cosmc-chaperone mutations in European IgA nephropathy patients. (18840896)	Malycha F.... Eitner F.	2009	C1GALT1, C1GALT1C1
10	Investigation of DNA polymorphisms in SMAD genes for genetic predisposition to diabetic nephropathy in patients with type 1 diabetes mellitus. (19247629)	McKnight A.J.... Maxwell A.P.	2009	SMAD3, SMAD4, SMAD1
11	A candidate gene approach to genetic prognostic factors of IgA nephropathy--a result of Polymorphism REsearch to DIstinguish genetic factors Contributing To progression of IgA Nephropathy (PREDICT-IgAN). (19420105)	Yamamoto R.... Rakugi H.	2009	ITGB2, VWF, ICAM1
12	Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy. (18184924)	Keene K.L.... Sale M.M.	2008	ENPP1
13	Endothelial dysfunction and inflammation predict development of diabetic nephropathy in the Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria (IRMA 2) study. (18609080)	Persson F.... Parving H.H.	2008	VWF, IL6
14	Serum cystatin C in diabetic patients. Not only an in dicator for renal dysfunction in patients with overt nephropathy but also a pre dictor for cardiovascular events in patients without nephropathy. (17980929)	Ogawa Y.... Suda T.	2008	TF
15	The current clinical problems for early phase of diabetic nephropathy and approach for pathogenesis of diabetic nephropathy. (18842318)	Doi T.... Abe H.	2008	ALB
16	Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population. (18560894)	Leak T.S.... Sale M.M.	2008	ESR1, PARK2
17	Association between haptoglobin gene variants and diabetic nephropathy: haptoglobin polymorphism in nephropathy susceptibility. (17220636)	Conway B.R.... Maxwell A.P.	2007	HP
18	Mild course of Puumala nephropathy in children in an area with sporadic occurrence Hantavirus infection. (17024393)	Dusek J.... Janda J.	2006	AMBP
19	CC-chemokine receptor five gene polymorphism in primary IgA nephropathy: the 32 bp deletion allele is associated with late progression to end-stage renal failure with dialysis. (16395252)	Berthoux F.C.... Linossier M.T.	2006	CCR5, CD79A
20	Urinary fibronectin excretion as a marker of disease activity in children with IgA nephropathy and Henoch-Schonlein nephropathy (16898499)	Roszkowska-Blaim M.... Bartl/omiejczyk I.	2006	FN1, CD79A
21	Review: ACE inhibitors delay onset of microalbuminuri a in diabetes without nephropathy and reduce mortality in diabetic nephropathy. (16944855)	McFarlane P.A.	2006	ACE
22	Impact of diabetic nephropathy and angiotensin II rec eptor blockade on urinary polypeptide patterns. (15954909)	Rossing K.... Kaiser T.	2005	ALB
23	The telmisartan renoprotective study from incipient nephropathy to overt nephropathy--rationale, study design, treatment plan and baseline characteristics of the incipient to overt: angiotensin II receptor blocker, telmisartan, Investigation on Type 2 Diabetic Nephropathy (INNOVATION) Study. (16372586)	Makino H.... Katayama S.	2005	ALB, AGTR2
24	Urinary liver-type fatty acid-binding protein: discrimination between IgA nephropathy and thin basement membrane nephropathy. (16118482)	Nakamura T.... Koide H.	2005	FABP1, CD79A
25	Identification and characterization of D8C, a novel domain present in liver-specific LZP, uromodulin and glycoprotein 2, mutated in familial juvenile hyperuricaemic nephropathy. (15589826)	Yang H.... Guo J.	2004	UMOD, GP2, OIT3
26	Cellular basis of diabetic nephropathy: III. In vitro GLUT1 mRNA expression and risk of diabetic nephropathy in type 1 diabetic patients. (15502921)	Huang C.... Mauer M.	2004	SLC2A1
27	Immunity of tonsil and IgA nephropathy--relationship between IgA nephropathy and tonsillitis. (15768789)	Kuki K.... Yamanaka N.	2004	CCL2
28	IgA nephropathy (immunoglobulin A nephropathy, M.Berger). Main symptoms: (painless) macrohematuria or microhematuria (15559904)	Kolyvanos Naumann U.... Vetter W.	2004	CD79A
29	Familial ATTR amyloidosis: microalbuminuria as a predictor of symptomatic disease and clinical nephropathy. (12584275)	Lobato L.... Sequeiros J.	2003	TTR
30	ACE-inhibitors but not endothelin receptor blockers prevent podocyte loss in early diabetic nephropathy. (12802493)	Gross M.L.... Amann K.	2003	EDN1
31	Protease-activated receptor-2 expression in IgA nephropathy: a potential role in the pathogenesis of interstitial fibrosis. (12874461)	Grandaliano G.... Schena F.P.	2003	F10, CD79A, F2RL1
32	ACE gene polymorphism and progression of diabetic nephropathy in Korean type 2 diabetic patients: effect of ACE gene DD on the progression of diabetic nephropathy. (12722028)	Ha S.K.... Han D.S.	2003	ACE
33	Additive antiproteinuric effect of combination therapy with ACE inhibitor and angiotensin II receptor antagonist: differential short-term response between IgA nephropathy and diabetic nephropathy. (12833584)	Kim M.J.... Kim G.A.	2003	ACE, CD79A
34	Cellular basis of diabetic nephropathy: II. The transforming growth factor-beta system and diabetic nephropathy lesions in type 1 diabetes. (12453917)	Huang C.... Mauer M.	2002	BMP6, LTBP1
35	Association of angiotensin I converting enzyme gene polymorphism with reflux nephropathy in children. (10971153)	Park H.W.... Choi Y.	2000	ACE
36	Lack of relationship in long-term type 1 diabetic patients between diabetic nephropathy and polymorphisms in apolipoprotein epsilon, lipoprotein lipase and cholesteryl ester transfer protein. Genetique de la Nephropathie Diabetique Study Group. Donnees Epidemiologiques sur le Syndrome d'Insulino-Resistance Study Group. (11096142)	Hadjadj S.... Marre M.	2000	LPL, APEX1, APOE
37	Increased frequency of surface IgA-positive plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA. (10903742)	Kamata T.... Honjo T.	2000	CD79A
38	Serum IgA levels in patients with diabetic nephropathy and IgA nephropathy superimposed on diabetes mellitus. (10802148)	Kanauchi M.... Dohi K.	2000	CD79A
39	A polymorphism in the gene for the atrial natriuretic peptide and diabetic nephropathy. Diabetic Nephropathy Study Group. (9681733)	Schmidt S.... Ritz E.	1998	NPPA
40	The renoprotective properties of angiotensin-converting enzyme inhibitors in a chronic model of membranous nephropathy are solely due to the inhibition of angiotensin II: evidence based on comparative studies with a receptor antagonist. (9016898)	Zoja C.... Remuzzi G.	1997	ACE
41	Evaluation of risk factors for the development of nephropathy in patients with IDDM: insertion/deletion angiotensin converting enzyme gene polymorphism, hypertension and metabolic control. (9084972)	Barnas U.... Mayer G.	1997	ACE, INS
42	Relationship between angiotensin 1 converting enzyme gene polymorphism and diabetic nephropathy (9596955)	Wu S.... Weng Q.	1997	ACE
43	Circulating factors in sera or peripheral blood mononuclear cells in patients with membranous nephropathy or diabetic nephropathy. (9443093)	Ihm C.G.... Kim M.J.	1997	CCL2
44	Angiotensinogen gene M235T polymorphism is not associated with diabetic nephropathy. The Diabetic Nephropathy Study Group. (8918618)	Schmidt S.... Ritz E.	1996	AGT
45	Changes in circulating immune complex and charge distribution with upper respiratory tract inflammation in IgA nephropathy. (7777101)	Yamaguchi K.... Hara K.	1995	CD79A
46	Macromolecular IgA and abnormal IgA reactivity in sera from children with IgA nephropathy. Italian Collaborative Paediatric IgA Nephropathy Study. (7697930)	Coppo R.... Rizzoni G.	1995	ALB, CD79A
47	Elevated plasma levels of acute phase proteins in mesangioproliferative glomerulonephritis, membranous nephropathy and IgA nephropathy. (7542398)	Tencer J.... Rippe B.	1995	ALB, HP
48	Natural history of early diabetic nephropathy: what are the effects of therapeutic intervention? Melbourne Diabetic Nephropathy Study Group. (8573754)	Jerums G.... Raffaele J.	1995	ACE
49	Association of ACE gene polymorphism and diabetic nephropathy? The Diabetic Nephropathy Study Group. (7783416)	Schmidt S.... Ritz E.	1995	ACE
50	The relationship between early diabetic nephropathy and control of plasma glucose in non-insulin-dependent diabetes mellitus. The effect of glycemic control on the development and progression of diabetic nephropathy in an 8-year follow-up study. (8167381)	Kawazu S.... Suzuki M.	1994	ALB

Genes related to nephropathy according to GeneCards:

(show top 50)    (show all 774)

id	Symbol	Description	Score	GeneCards Section Context
1	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.1	Publications, Summaries
2	UMOD	uromodulin	11.1	Publications, Summaries
3	SELL	selectin L	11.0	Publications, Summaries
4	PIGR	polymeric immunoglobulin receptor	11.0	Publications, Summaries
5	HP	haptoglobin	11.0	Publications, Summaries
6	ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	11.0	Publications, Summaries
7	SGK1	serum/glucocorticoid regulated kinase 1	11.0	Publications, Functions, Summaries
8	TSC22D1	TSC22 domain family, member 1	11.0	Publications, Summaries
9	NEDE	nephropathy, progressive, with deafness	11.0	Publications, Aliases & Descriptions
10	XPNPEP3	X-prolyl aminopeptidase (aminopeptidase P) 3, putative	11.0	Publications, Summaries
11	TINAG	tubulointerstitial nephritis antigen	11.0	Publications, Summaries
12	CFH	complement factor H	11.0	Publications, Summaries
13	ELMO1	engulfment and cell motility 1	11.0	Publications, Summaries
14	FRMD3	FERM domain containing 3	11.0	Publications, Summaries
15	HNFJ3	Hyperuricemic nephropathy, familial juvenile, 3	11.0	Aliases & Descriptions
16	IGAN2	IgA nephropathy, susceptibility to, 2	11.0	Aliases & Descriptions
17	DIANPH	diabetic nephropathy	11.0	Aliases & Descriptions
18	HNP1	Hypertensive nephropathy	11.0	Publications, Aliases & Descriptions
19	IGAN	IgA nephropathy	11.0	Publications, Aliases & Descriptions
20	COQ2	coenzyme Q2 homolog, prenyltransferase (yeast)	11.0	Publications, Summaries
21	PLA2R1	phospholipase A2 receptor 1, 180kDa	11.0	Publications, Summaries
22	ALB	albumin	11.0	Publications
23	NPHS1	nephrosis 1, congenital, Finnish type (nephrin)	11.0	Publications
24	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
25	REN	renin	11.0	Publications
26	PGM3	phosphoglucomutase 3	11.0	Summaries
27	BBS7	Bardet-Biedl syndrome 7	11.0	Summaries
28	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
29	HNF1B	HNF1 homeobox B	11.0	Publications
30	TGFB1	transforming growth factor, beta 1	11.0	Publications
31	NAGLU	N-acetylglucosaminidase, alpha	11.0	Publications
32	AMBP	alpha-1-microglobulin/bikunin precursor	11.0	Publications
33	NPHS2	nephrosis 2, idiopathic, steroid-resistant (podocin)	11.0	Publications
34	SERPINB7	serpin peptidase inhibitor, clade B (ovalbumin), member 7	11.0	Publications
35	SYNPO	synaptopodin	11.0	Publications
36	AGTR1	angiotensin II receptor, type 1	11.0	Publications
37	B2M	beta-2-microglobulin	11.0	Publications
38	BMP6	bone morphogenetic protein 6	11.0	Publications
39	INS	insulin	11.0	Publications
40	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.0
41	SELE	selectin E	11.0	Publications
42	CTGF	connective tissue growth factor	11.0	Publications
43	AGT	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	11.0	Publications
44	AGTR2	angiotensin II receptor, type 2	11.0	Publications
45	CD2AP	CD2-associated protein	11.0	Publications
46	ADM	adrenomedullin	11.0	Publications
47	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
48	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
49	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
50	COL4A1	collagen, type IV, alpha 1	11.0	Publications

Pathways related to nephropathy according to GeneDecks:

(show top 50)    (show all 168)

id	Pathway	Score	Top Affiliating Genes
1	Rho Family GTPases36	18.9	KITLG, VEGFC, BMP2, BMP4, BMP6, BMP7
2	Transendothelial Migration of Leukocytes36	17.3	VCAM1, PAK3, SDC2, LAMA1, LAMA4, LAMB1
3	Akt Signaling36	17.0	VEGFC, BMP2, BMP4, BMP7, BMPR1A, UTS2
4	Cytokine-cytokine receptor interaction20	16.7	KITLG, VEGFA, VEGFC, BMP2, BMP7, BMPR1A
5	Pancreatic Adenocarcinoma36	16.5	KITLG, RB1, VEGFC, BMP2, BMP4, BMP6
6	Estrogen Pathway36	15.9	KITLG, VEGFC, BMP2, BMP4, BMP6, BMP7
7	Activation of PKA through GPCR36	15.9	KITLG, GCG, VEGFC, BMP2, BMP4, BMP6
8	Pathways in cancer20	15.7	RELA, RB1, VEGFA, VEGFC, BMP2, BMP4
9	p70S6K Signaling36	15.6	KITLG, VEGFC, BMP2, BMP4, BMP6, BMP7
10	Epithelial Adherens Junctions36	15.3	KITLG, VEGFC, BMP2, BMP4, BMP6, BMP7
11	UPA-UPAR Pathway36	15.2	VTN, SERPINE1, LAMA1, LAMA4, LAMB1, LAMB2
12	STAT3 Pathway36	15.2	BMP2, BMP4, BMP6, BMP7, BMPR1A, LIF
13	NF-KappaB Family Pathway36	15.1	RELA, KITLG, VEGFC, MYD88, BMP2, BMP4
14	NFAT in Immune Response36	15.0	KITLG, VEGFC, BMP2, BMP4, BMP6, BMP7
15	Rac1 Pathway36	14.8	KITLG, BMP4, BMP6, BMP7, UTS2, PAK3
16	p53 Mediated Apoptosis36	14.7	KITLG, VEGFC, BMP2, BMP4, BMP6, BMP7
17	Paxillin Interactions36	14.6	KITLG, VEGFC, BMP2, BMP4, UTS2, PAK3
18	Nuclear Receptor Activation by Vitamin-A36	14.3	KITLG, VEGFC, BMP2, BMP4, BMP6, BMP7
19	eNOS Signaling36	14.3	KITLG, BMP2, BMP6, BMP7, UTS2, BDKRB1
20	eIF2 Pathway36	14.2	KITLG, VEGFC, BMP4, BMP6, BMP7, UTS2
21	TGF-beta Signaling Pathways37	14.1	RELA, MTOR, JUN, CDC42, AR, ENG
22	Glioma Invasiveness36	14.1	KITLG, VTN, VEGFC, BMP2, BMP4, BMP6
23	PEDF Induced Signaling36	14.0	RELA, SERPINF1, BMP2, BMP4, BMP6, BMP7
24	Integrin Pathway36	14.0	PAK3, LAMA1, LAMA4, LAMB1, LAMB2, LAMC1
25	Angiogenesis3	13.9	REN, VEGFC, KDR, JAG1, ITGB1, ITGB3
26	Immune System38	13.9	PDCD1, KIF3A, VCAM1, LGALS3, CISH, MX1
27	FAK1 Signaling36	13.7	PAK3, LAMA1, LAMA4, LAMB1, LAMB2, LAMC1
28	Cell adhesion ECM remodeling10	13.7	VTN, SERPINE1, SDC2, LAMA1, LAMA4, LAMB1
29	Glucocorticoid Receptor Signaling36	13.7	BMP2, BMP4, BMP6, BMP7, JUN, CDKN1A
30	Cell adhesion_ECM remodeling41	13.6	VTN, SERPINE1, SDC2, LAMA1, LAMA4, LAMB1
31	CREB Pathway36	13.2	KITLG, BMP2, BMP4, BMP6, BMP7, UTS2
32	Cell adhesion_Plasmin signaling41	13.0	VEGFA, KDR, LAMA1, LAMB1, LAMC1, FN1
33	Osteoclast differentiation20	13.0	RELA, JUN, JAK1, ITGB3, FCGR2A, FCGR3A
34	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	13.0	REN, CMA1, BDKRB1, BDKRB2, ATP6AP2, MME
35	RAR-Gamma-RXR-Alpha Degradation36	12.9	BMP2, BMP4, BMP7, LIF, UBD, CDK7
36	Cell adhesion Plasmin signaling10	12.9	VEGFA, KDR, LAMA1, LAMB1, LAMC1, FN1
37	Pertussis20	12.8	RELA, MYD88, JUN, CD14, ITGB1, ITGB2
38	ECM-receptor interaction20	12.6	VWF, VTN, SDC2, LAMA1, LAMA4, LAMB1
39	Actin-Based Motility by Rho Family GTPases36	12.5	BMP4, BMP7, UTS2, PAK3, ITGA2B, ITGAL
40	Leishmaniasis20	12.1	RELA, MYD88, JUN, JAK1, JAK2, ITGB1
41	Prostate cancer20	11.9	RELA, RB1, MTOR, CDKN1A, CDK2, CDKN1B
42	ACE Inhibitor Pathway, Pharmacodynamics34	11.8	CMA1, BDKRB1, BDKRB2, ATP6AP2, MME, NR3C2
43	Blood Coagulation Signaling Pathways37	11.6	VWF, SERPINB2, SERPINE1, FGB, GP1BA, GP6
44	Rheumatoid arthritis20	11.5	VEGFA, JUN, CD28, CD86, CD80, ITGAL
45	Immune response_IL-22 signaling pathway41	10.8	JUN, JAK1, JAK2, CD28, CD86, CD4
46	Immune response IL-22 signaling pathway10	10.5	JUN, JAK1, JAK2, CD28, CD86, CD4
47	Complement and coagulation cascades20	INF	VWF, SERPINA1, SERPINE1, BDKRB1, BDKRB2, CFH
48	all-trans-Retinoic Acid Signaling in Brain36	INF	BMP2, BMP4, BMP6, BMP7, RARA, LIF
49	Antioxidant Action of Vitamin-C36	INF	KITLG, VEGFC, BMP2, BMP4, BMP6, BMP7
50	DHA Signaling36	INF	KITLG, SERPINF1, VEGFC, BMP2, BMP4, BMP6

Compounds related to nephropathy according to GeneDecks:

(show top 50)    (show all 499)

id	Compound	Score	Top Affiliating Genes
1	cholesterol32 9 18 9	INF	LRP1, LRP2, , COG2, REN, RETN
2	sucrose32 9 18 9	INF	LRP1, LRP2, , GCK, GCG, RBP4
3	ndga32	INF	VCAM1, JUN, MMP3, IL1B, IL2RA, MAPK10
4	atorvastatin32 34 9 18 9	INF	COG2, RETN, VWF, SELE, SELL, SELP
5	mannose32	INF	LRP1, , GCK, CLEC12A, PAPPA,
6	dexamethasone32 42 34 9 9	INF	LRP1, , REN, RETN, SGK1, KITLG
7	potassium32 9 18 9	20.9	COG2, REN, SGK1, KITLG, VTN, GCK
8	forskolin32 42 9 9	20.8	REN, RETN, PCSK1, GCK, GCG, GCM1
9	progesterone32 42 9 18 9	21.3	PCNA, PCSK1, GCK, RB1, RBP4, SERPINB2
10	folate32	16.6	LRP2, VWF, GCH1, RBP4, SELE, NAT2
11	cytochalasin d32 42	17.4	KITLG, VWF, VTN, SELE, SELL, LPL
12	homocysteine32 18	16.5	COG2, RETN, VWF, SELE, SELP, SERPINE1
13	endotoxin32	14.7	RETN, SELL, SERPINB2, MYD88, LIF, SCGB1A1
14	p00332	14.4	COG2, RETN, RB1, SERPINA1, SERPINE1, LIPC
15	phorbol32	13.9	RBP4, SELL, SERPINB2, CHGA, JUN, CDKN1A
16	mg 13232 42	14.8	PCNA, VDR, RARA, BLZF1, PARK2, KDR
17	imatinib32 34 9 9	16.7	KITLG, SELL, VEGFA, BMP6, RARA, KDR
18	paclitaxel32 34 9 9	16.6	KITLG, PCNA, RB1, VEGFA, BMP6, RARA
19	warfarin32 34 9 18 9	17.3	VWF, SELP, NAT2, LPA, MTHFR, AXL
20	mannose 6-phosphate32 18	14.3	PIGR, LRP1, REN, RENBP, GCK, SELL
21	cholesterol ester32	13.2	LRP1, COG2, LPA, LPL, LIPC, LCAT
22	ramipril32 9 9	15.1	REN, SERPINE1, CD79A, INS, ALB, HMGCR
23	carbon32	13.1	VWF, VTN, PCNA, NAGA, LPL, VDR
24	alpha lipoic acid32	13.1	SERPINA1, VCAM1, MMP9, INS, CCL2, HSPA1A
25	bromodeoxyuridine32	13.0	KITLG, PCNA, RB1, BMP4, BMP6, BMP7
26	valsartan32 42 9 9	16.0	REN, SELP, SERPINE1, CCL2, ALB, CYP2C9
27	progestins32	12.8	LIF, LIPC, JAK2, MMP3, AR, CCND1
28	allergens32	12.4	LRP2, PDCD1, BLZF1, CMA1, LGALS3, S100A8
29	lipoteichoic acid32	12.4	SELE, MYD88, CD14, IL10, IL18, IL1B
30	etanercept32 9 9	14.3	LEP, MMP12, MMP3, FCGR2A, FCGR3A, FCGR3B
31	groalpha32	12.3	SELE, VCAM1, IL10, IL13, IL17A, IL18
32	clonidine32 9 9	13.8	REN, LEP, CHGA, FGF2, IL1RAPL2, IGFBP3
33	trastuzumab32 34 9 9	14.7	VEGFC, KDR, CDK2, CDKN1B, FCGR2A, FCGR3A
34	gm-csf32	11.6	KITLG, VEGFA, BMP6, LIF, CD14, IL10
35	atenolol32 9 18 9	13.7	SERPINE1, CYP11B2, CYP2D6, ABCB1, ADRB2, ADRB1
36	atp32	INF	RENBP, VTN, GCK, RB1, SERPINH1, NAGA
37	staurosporin32	INF	JUN, ITGAL, IL8, MAPK14, MAPK10, CASP3
38	lactose32 9 9	INF	SELE, SELL, , LGALS3, FUT4, CD40LG
39	uric acid32 18	INF	RETN, RBP4, SERPINE1, NAGLU, LPA,
40	ibuprofen32 9 18 9	INF	VCAM1, BMP6, LEP, MMP2, MMP3, IL10
41	rituximab32 34 9 9	INF	MTOR, CD79A, , CD40LG, CD80, CD55
42	phosphotyrosine32	INF	BLZF1, KDR, , JAK2, CD28, CDK2
43	pdtc32	INF	GCLM, SELE, VCAM1, XDH, JUN, CDKN1A
44	nitric oxide32 9 18 9	INF	COG2, REN, RETN, KITLG, GCK, GCH1
45	gf 109203x32 42	INF	KITLG, VEGFA, JUN, JAK2, CDKN1A, ITGA2B
46	palmitate32	INF	GCG, SELE, UCP1, UCP2, UCP3, CETP
47	calcium32 9 18 9	INF	PIGR, LRP1, , COG2, NCALD, REG1A
48	agarose32	INF	KITLG, VWF, SERPINA1, LPA, BMP7, LIF
49	histidine32	INF	KITLG, RARA, KCNJ11, , CHGA, MTR
50	glycerol32 9 18 9	INF	VWF, PCNA, GCK, GCG, NAGA, LPL

Cellular components related to nephropathy according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	INF	LRRC7, LRP1, LRRC16A, RELA, KITLG, PCNA
2	plasma membrane	GO:005886	INF	LRRC7, LRP2, , PDCD1, SGK1, KITLG
3	extracellular space	GO:005615	INF	LRG1, LRP2, REN, KITLG, VTN, PCSK1N
4	cell surface	GO:009986	INF	, VEGFA, LPL, VCAM1, BMP2, RARA
5	cytosol	GO:005829	21.6	LRRC16A, NCALD, RELA, CNDP2, KIF3A, VPS4B
6	integral to plasma membrane	GO:005887	19.8	PIGR, LRP1, SELL, SELP, CLCNKB, BDKRB1
7	platelet alpha granule lumen	GO:031093	13.4	VWF, SERPINA1, SERPINE1, VEGFA, VEGFC, CLU
8	membrane raft	GO:045121	13.1	SELE, UMOD, JAK2, CD79A, CD36, CD14
9	external side of plasma membrane	GO:009897	12.9	VWF, SELL, SELP, VCAM1, KDR, B2M
10	proteinaceous extracellular matrix	GO:005578	INF	VWF, SERPINA1, VEGFA, BMP4, , LGALS3
11	extracellular matrix	GO:031012	INF	VWF, VTN, SERPINF1, SERPINE1, LPL, CMA1
12	extracellular region	GO:005576	INF	PIGR, LRG1, , REG1A, RETN, CNDP1
13	secretory granule	GO:030141	INF	PCSK1N, PCSK1, GCK, GCG, VEGFA, CHGA

Biological processes related to nephropathy according to GeneDecks:

(show top 50)    (show all 63)

id	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:006954	17.5	RELA, SELE, SELP, VNN1, MYD88, BMP2
2	proteolysis	GO:006508	16.1	REN, CNDP1, CNDP2, PCSK1, LPA, CMA1
3	positive regulation of cell proliferation	GO:008284	15.9	REG1A, NAMPT, VEGFA, VEGFC, RARA, LIF
4	response to hypoxia	GO:001666	15.6	SERPINA1, VEGFA, VCAM1, BMP2, UTS2, SDC2
5	platelet activation	GO:030168	15.6	VWF, SELP, SERPINA1, SERPINE1, VEGFA, VEGFC
6	negative regulation of apoptotic process	GO:043066	15.3	RELA, GCG, SERPINE1, VEGFA, BMP4, CLU
7	negative regulation of cell proliferation	GO:008285	15.3	VDR, BMP2, BMP4, LIF, BDKRB2, ZEB1
8	innate immune response	GO:045087	15.3	RELA, VNN1, MYD88, CLU, LGALS3, MX1
9	cell-cell signaling	GO:007267	15.2	PCSK1, NAMPT, BMP2, S100A9, XCL1, CD86
10	cell adhesion	GO:007155	15.0	KITLG, VWF, VTN, SELL, SELP, VCAM1
11	platelet degranulation	GO:002576	14.4	VWF, SELP, SERPINA1, SERPINE1, VEGFA, VEGFC
12	aging	GO:007568	14.0	LRP2, SERPINF1, VDR, VCAM1, UCP3, JUN
13	extracellular matrix organization	GO:030198	14.0	SERPINH1, CMA1, LGALS3, MMP14, MMP16, MMP2
14	positive regulation of cell migration	GO:030335	13.9	VEGFA, BMP2, KDR, LAMB1, JAK2, CDH13
15	immune response	GO:006955	13.8	VTN, BMP6, BMPR1A, LIF, ZEB1, XCL1
16	response to glucocorticoid stimulus	GO:051384	13.8	PCSK1, SERPINF1, SERPINE1, UCP3, LCAT, IL10
17	regulation of blood pressure	GO:008217	13.5	REN, RENBP, SGK1, GCH1, UTS2, LEP
18	positive regulation of angiogenesis	GO:045766	13.4	SERPINE1, VEGFA, UTS2, UTS2R, KDR, MMP9
19	response to lipopolysaccharide	GO:032496	13.4	PCSK1, GCH1, SELE, SELP, SERPINA1, BDKRB1
20	positive regulation of MAPK cascade	GO:043410	13.3	LIF, KDR, LEP, CD36, ITGB1, FLT1
21	positive regulation of smooth muscle cell proliferation	GO:048661	13.2	MYD88, BMP4, JUN, CDH13, FLT1, IL13
22	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	13.1	KITLG, VTN, VEGFA, LIF, MTOR, JAK2
23	anti-apoptosis	GO:006916	13.1	RELA, SERPINB2, VNN1, MYD88, PAX2, MPO
24	heart development	GO:007507	13.1	PCNA, RBP4, VCAM1, BMP2, SALL1, GYS1
25	positive regulation of apoptotic process	GO:043065	13.1	BMP2, BMP4, CLU, UBD, JAK2, ITGB1
26	lipoprotein metabolic process	GO:042157	12.9	LPA, LPL, LCAT, MTTP, CETP, APOA1
27	positive regulation of protein kinase B signaling cascade	GO:051897	12.8	MTOR, AXL, INS, ILK, ANGPT1, GPX1
28	chemotaxis	GO:006935	12.8	S100A8, S100A9, FGF2, IL4, MAPK14, MAPK1
29	elevation of cytosolic calcium ion concentration	GO:007204	12.8	GCK, UTS2, UTS2R, BDKRB1, BDKRB2, JAK2
30	positive regulation of endothelial cell proliferation	GO:001938	12.7	VEGFA, BMP2, BMP4, BMP6, KDR, MTOR
31	extracellular matrix disassembly	GO:022617	12.7	CMA1, LAMC1, MMP14, MMP16, MMP2, MMP3
32	response to estradiol stimulus	GO:032355	12.5	SERPINA1, VDR, BMP4, RARA, MMP9, IL1B
33	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	12.5	SELP, KDR, JAK2, FLT1, INS, ANGPT1
34	response to organic cyclic compound	GO:014070	12.4	SELP, SERPINA1, BMP4, JUN, CDKN1A, IL1A
35	positive regulation of ERK1 and ERK2 cascade	GO:070374	12.4	GCG, BMP2, BMP4, KDR, CD44, MIF
36	wound healing	GO:042060	12.3	SDC2, S100A8, ITGB3, FMOD, MIA3, INS
37	positive regulation of protein phosphorylation	GO:001934	12.3	VEGFA, BMP2, BMP4, MTOR, ITGB3, FGF1
38	negative regulation of angiogenesis	GO:016525	12.3	SERPINF1, VASH1, LIF, APOH, FASLG, CCR2
39	cytokine-mediated signaling pathway	GO:019221	11.9	RELA, VCAM1, MYD88, MX1, B2M, JAK1
40	response to ethanol	GO:045471	11.9	RBP4, S100A8, S100A9, MMP9, IL13, IL4
41	cell surface receptor signaling pathway	GO:007166	INF	MYD88, BDKRB2, LAMA1, CD28, CD36, CD14
42	positive regulation of inflammatory response	GO:050729	INF	SERPINE1, JAK2, IL15, IL18, IL2, FABP4
43	blood coagulation	GO:007596	INF	LRRC16A, KIF3A, VWF, SELL, SELP, SERPINB2
44	response to drug	GO:042493	INF	LRP2, REN, PCSK1, GCLM, VEGFC, LPL
45	negative regulation of cell growth	GO:030308	INF	RB1, BDKRB1, CDKN1A, CDKN1B, CDKN2A, FGF2
46	small molecule metabolic process	GO:044281	INF	LRP2, CNDP2, PCSK1, GCK, GCG, GCH1
47	signal transduction	GO:007165	INF	PDCD1, KITLG, GCG, NAMPT, VEGFC, VDR
48	positive regulation of transcription, DNA-dependent	GO:045893	INF	RELA, RB1, BMP2, BMP4, BMP7, BMPR1A
49	angiogenesis	GO:001525	INF	SERPINE1, VEGFA, VEGFC, VASH1, KDR, JUN
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	RELA, RB1, SERPINE1, VEGFA, VDR, MYD88

Molecular functions related to nephropathy according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:042803	INF	CCR2, MASP1, MAF, ENG, ENPP1, APOE
2	receptor binding	GO:005102	14.9	REN, MBL2, ENSA, ANG, CCL2, ICAM3
3	growth factor activity	GO:008083	13.7	LEP, LIF, BMP7, BMP6, BMP4, BMP2
4	integrin binding	GO:005178	12.9	ILK, ICAM3, ITGB1, ITGB6, KDR, IGF1
5	collagen binding	GO:005518	12.8	VWF, SERPINH1, CD44, SPARC, DDR1, GP6
6	cytokine activity	GO:005125	12.7	FGF2, TNFSF14, SPP1, LTA, EDN1, OSM
7	hormone activity	GO:005179	12.1	EDN1, SST, EPO, AGT, TTR, TG
8	heparin binding	GO:008201	INF	PF4, ADAMTS1, KNG1, PGF, THBS4, THBS1
9	protein heterodimerization activity	GO:046982	INF	ITGB1, APOB, APOE, CYBA, MAF, HNF1A
10	protein binding	GO:005515	INF	AGER, STAT5B, STAT1, STAT3, DES, SYNPO