MCID: NPH016
MIFTS: 33

Nephropathy-Hypertension malady

Nephrological category

Summaries for Nephropathy-Hypertension

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33MalaCards
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MalaCards: Nephropathy-Hypertension, also known as hypertensive nephropathy, is related to hypertensive nephropathy and diabetic nephropathy. An important gene associated with Nephropathy-Hypertension is RFH1 (Renal failure, progressive, with hypertension), and among its related pathways are Amine compound SLC transporters and GABA synthesis, release, reuptake and degradation. The compounds indapamide and Estropipate have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and liver, and related mouse phenotype renal/urinary system.

Aliases & Classifications for Nephropathy-Hypertension

Sources:
47OMIM, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Aliases & Descriptions:

nephropathy-hypertension 47
hypertensive nephropathy 61


Related Diseases for Nephropathy-Hypertension

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Nephropathy-Hypertension:



Diseases related to nephropathy-hypertension

Clinical Features for Nephropathy-Hypertension

Drugs & Therapeutics for Nephropathy-Hypertension

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Nephropathy-Hypertension

Drug clinical trials:

Search ClinicalTrials for Nephropathy-Hypertension

Search NIH Clinical Center for Nephropathy-Hypertension

Search CenterWatch for Nephropathy-Hypertension

Genetic Tests for Nephropathy-Hypertension

Anatomical Context for Nephropathy-Hypertension

Sources:
33MalaCards
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MalaCards organs/tissues related to Nephropathy-Hypertension:

33
Heart, Kidney, Liver, T cells

Animal Models for Nephropathy-Hypertension or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Nephropathy-Hypertension:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.2ALB, ACE, SLC22A2, SLC22A1

Publications for Nephropathy-Hypertension

Sources:
51PubMed
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Articles related to Nephropathy-Hypertension:

(show top 50)    (show all 59)
idTitleAuthorsYear
1
Antihypertensive treatment and resistant hypertension in patients with type 1 diabetes by stages of diabetic nephropathy. (24170765)
2013
2
Malignant hypertension and nephrotic range proteinuria without hematuria: IgA nephropathy. (24049285)
2013
3
Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans. (22832513)
2013
4
Functional expression of TRPV4 channels in human collecting duct cells: implications for secondary hypertension in diabetic nephropathy. (23049542)
2012
5
Pathogenesis and management of renovascular hypertension and ischemic nephropathy. (22402318)
2012
6
Hemolytic-uremic syndrome, malignant hypertension and IgA nephropathy: successful treatment with plasma exchange therapy. (22892290)
2012
7
Common genetic variants in the chromogranin a promoter are associated with renal injury in IgA nephropathy patients with malignant hypertension. (20113265)
2010
8
Association of the SLC22A1, SLC22A2, and SLC22A3 genes encoding organic cation transporters with diabetic nephropathy and hypertension. (20429798)
2010
9
Renovascular hypertension and ischemic nephropathy. (20864945)
2010
10
Malignant hypertension associated with IgA nephropathy. (20840215)
2010
11
The role of the renin-angiotensin-aldosterone system in renal artery stenosis, renovascular hypertension, and ischemic nephropathy: diagnostic implications. (19917331)
2009
12
Protective effects of efonidipine, a T- and L-type calcium channel blocker, on renal function and arterial stiffness in type 2 diabetic patients with hypertension and nephropathy. (19749494)
2009
13
Polymorphism of the aldosterone synthase gene is not associated with progression of diabetic nephropathy, but associated with hypertension in type 2 diabetic patients. (18771471)
2008
14
Malignant hypertension in IgA nephropathy was not associated with background pathological phenotypes of glomerular lesions. (18603547)
2008
15
Irbesartan: a review of its use in hypertension and diabetic nephropathy. (18627212)
2008
16
Idiopathic membranous nephropathy complicated with malignant hypertension: a case report. (17711746)
2007
17
Imidapril: a review of its use in essential hypertension, Type 1 diabetic nephropathy and chronic heart failure. (17547476)
2007
18
The link between Glut-1 and hypertension in diabetic nephropathy. (16600163)
2006
19
Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy. (16091581)
2006
20
Malignant hypertension in patients with idiopathic IgA nephropathy. (16340218)
2005
21
Retarding the progression of diabetic nephropathy in type 2 diabetes mellitus: focus on hypertension and proteinuria. (15726216)
2005
22
Irbesartan: a review of its use in hypertension and in the management of diabetic nephropathy. (15101793)
2004
23
Predictors of cardiovascular events in patients with type 2 diabetic nephropathy and hypertension: a case for albuminuria. (15485418)
2004
24
Case 4: eruption on the face of a diabetic man suffering from retinopathy, hypertension, and nephropathy. Diagnosis: ciclosporin-associated hyperplastic folliculitis. (12780737)
2003
25
Insulin resistance highly associates with hypertension in IgA nephropathy. (12608549)
2003
26
Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension. (12540629)
2003
27
Plasma prekallikrein: a risk marker for hypertension and nephropathy in type 1 diabetes. (12716755)
2003
28
Therapeutic controversies in hypertension management: angiotensin converting enzyme (ACE) inhibitors or angiotensin receptor blockers for diabetic nephropathy? A case for ACE inhibitors. (12477155)
2002
29
Slowing the progression of chronic renal insufficiency with captopril in rats with spontaneous arterial hypertension and adriamycin nephropathy]. (12154518)
2002
30
G protein beta 3 subunit 825T allele, hypertension, obesity, and diabetic nephropathy. (10978382)
2000
31
The ACE inhibitor spirapril in chronic renal failure, hypertension and diabetic nephropathy]. (11220886)
2000
32
G-Protein beta(3) subunit C825T variant, nephropathy and hypertension in patients with type 2 (Non-insulin-dependent) diabetes mellitus. (10970984)
2000
33
Inhibitory effects of a subdepressor dose of L-158,809, an angiotensin II type 1 receptor antagonist, on cardiac hypertrophy and nephropathy via the activated human renin-angiotensin system in double transgenic mice with hypertension. (9741738)
1998
34
Beta3-adrenergic receptor gene polymorphism is not associated with hypertension in NIDDM patients without nephropathy. (9851671)
1998
35
Chronicity index and mesangial IgG deposition are risk factors for hypertension and renal failure in early IgA nephropathy. (9631840)
1998
36
Predisposition to essential hypertension and development of diabetic nephropathy in IDDM patients. (9519751)
1998
37
Evaluation of risk factors for the development of nephropathy in patients with IDDM: insertion/deletion angiotensin converting enzyme gene polymorphism, hypertension and metabolic control. (9084972)
1997
38
Genetic variants of the renin-angiotensin system, diabetic nephropathy and hypertension. (9049480)
1997
39
Insulin resistance, hypertension and nephropathy. (9240760)
1996
40
Effect of chronic intermittent intravenous insulin therapy on antihypertensive medication requirements in IDDM subjects with hypertension and nephropathy. (8612440)
1995
41
Predictors for hypertensive nephropathy: results of a 6-year follow-up study in essential hypertension. (7622857)
1995
42
Therapeutic safety of perindopril in the treatment of mild hypertension with concomitant nephropathy. (8216441)
1993
43
Red blood cell Li+/Na+ exchange in patients with diabetic nephropathy and essential hypertension: therapeutic implications. (8516486)
1993
44
Management of renal disease and hypertension in insulin-dependent diabetes, with an emphasis on early nephropathy. (1365821)
1992
45
Recent advances in pharmacological management of hypertension in diabetic patients with nephropathy. Effects of antihypertensive drugs on kidney function and insulin sensitivity. (1377114)
1992
46
Predisposition to essential hypertension and the development of diabetic nephropathy. (1457758)
1992
47
Should ACE inhibitors be the drugs of choice in the treatment of hypertension in diabetes mellitus? ACE inhibitors are the drugs of choice in diabetic nephropathy. (1887338)
1991
48
Malignant hypertension due to reflux nephropathy in an adolescent (a case report). (1784033)
1991
49
Idiopathic IgA nephropathy presenting as malignant hypertension. (3565507)
1986
50
Bilateral nephrectomy and chronic hemodialysis in renal failure due to diabetic nephropathy complicated by malignant hypertension and cerebral edema. (683408)
1978

Genetic Variations for Nephropathy-Hypertension

Expression for genes affiliated with Nephropathy-Hypertension

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephropathy-Hypertension

Search GEO for disease gene expression data for Nephropathy-Hypertension.

Pathways for genes affiliated with Nephropathy-Hypertension

Sources:
54Reactome, 50PharmGKB
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Compounds for genes affiliated with Nephropathy-Hypertension

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB, 2BitterDB, 60Tocris Bioscience
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Compounds related to Nephropathy-Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1indapamide45 1110.9ALB, ACE
2Estropipate119.7SLC22A1, ALB
3fosinopril45 1110.7ACE, ALB
4thiothixene29 1110.7ALB, SLC22A1
5Acepromazine119.7ALB, SLC22A1
6Thioproperazine119.6SLC22A1, ALB
7Pipotiazine119.6SLC22A1, ALB
8indoxyl sulfate459.5SLC22A2, ALB
9hydrochlorothiazide45 50 29 11 2413.5ALB, GNB3, ACE
10cirazoline459.5SLC22A2, SLC22A3
11Tubocurarine119.4SLC22A1, SLC22A2
12pancuronium45 29 1111.3SLC22A2, SLC22A1
13phenformin45 1110.2SLC22A2, SLC22A1
14clonidine45 29 1111.2SLC22A1, GNB3, SLC22A3
15disopyramide45 1110.2SLC22A1, SLC22A2
16moxonidine459.2ACE, SLC22A2, SLC22A3
17Aminohippurate119.0SLC22A1, SLC22A2
18chlorpheniramine45 2 11 2412.0SLC22A1, SLC22A2, ALB
19probenecid45 29 60 50 1113.0SLC22A1, SLC22A2, ALB
20moxa459.0SLC22A2, SLC22A1, SLC22A3
21Histamine Phosphate119.0SLC22A1, SLC22A3, SLC22A2
22phenoxybenzamine45 119.9SLC22A2, SLC22A3, SLC22A1
23procainamide45 119.9SLC22A1, SLC22A3, SLC22A2
24agmatine45 29 11 2411.9SLC22A1, SLC22A2, SLC22A3
251 methyl 4 phenylpyridinium458.9SLC22A1, SLC22A2, SLC22A3
26Cladribine118.9SLC22A2, SLC22A1
27prazosin45 29 50 1111.9SLC22A3, SLC22A2, SLC22A1
28lamivudine45 119.9SLC22A3, SLC22A2, SLC22A1
29guanidine45 11 2410.9SLC22A3, SLC22A1, SLC22A2
30desipramine45 50 1110.9SLC22A3, SLC22A2, SLC22A1
31tetraethylammonium45 29 1110.9SLC22A2, SLC22A3, SLC22A1
32cimetidine45 29 1110.9SLC22A3, SLC22A1, SLC22A2
33oxaliplatin45 50 1110.9SLC22A3, SLC22A2, SLC22A1
34imipramine45 50 29 11 2412.9SLC22A3, SLC22A1, SLC22A2
35nifedipine45 50 29 1111.8ACE, SLC22A2, SLC22A3
36carnitine458.8SLC22A3, SLC22A2, SLC22A1
37corticosterone45 60 2410.8SLC22A3, SLC22A2, SLC22A1
38catecholamine458.8SLC22A3, SLC22A2, SLC22A1
39metformin45 50 1110.5SLC22A2, ACE, SLC22A1, SLC22A3
40verapamil45 50 29 11 2412.5ACE, SLC22A3, SLC22A2, SLC22A1
41choline45 11 2410.5SLC22A3, SLC22A2, SLC22A1
42sodium45 249.5ACE, SLC22A2, GNB3, ALB
43acetylcholine45 50 29 11 2412.5SLC22A3, SLC22A2, ACE, SLC22A1
44histamine45 29 2410.4SLC22A3, ALB, SLC22A1, SLC22A2
45estradiol45 11 2410.4SLC22A3, SLC22A1, SLC22A2, ALB
46epinephrine45 11 2410.4GNB3, SLC22A3, SLC22A1, SLC22A2
47imatinib45 50 1110.3ALB, SLC22A2, SLC22A1
48creatinine458.1ALB, SLC22A1, ACE, SLC22A3, SLC22A2
49norepinephrine45 11 2410.0GNB3, SLC22A3, SLC22A1, SLC22A2, ACE
50glucose458.0ACE, GNB3, SLC22A1, SLC22A2, ALB

GO Terms for genes affiliated with Nephropathy-Hypertension

Sources:
16Gene Ontology
See all sources

Biological processes related to Nephropathy-Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.5ACE, GNB3
2dopamine transportGO:0158729.3SLC22A1, SLC22A3
3drug transmembrane transportGO:0068558.6SLC22A2, SLC22A3, SLC22A1
4organic cation transportGO:0156958.6SLC22A3, SLC22A1, SLC22A2
5transmembrane transportGO:0550858.0SLC22A3, SLC22A1, SLC22A2, ALB
6small molecule metabolic processGO:0442817.2ALB, SLC22A2, SLC22A1, SLC22A3, GNB3

Molecular functions related to Nephropathy-Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.6ALB, ACE
2dopamine transmembrane transporter activityGO:0053299.0SLC22A3, SLC22A1
3secondary active organic cation transmembrane transporter activityGO:0085138.9SLC22A1, SLC22A2
4quaternary ammonium group transmembrane transporter activityGO:0156518.6SLC22A2, SLC22A1, SLC22A3
5organic cation transmembrane transporter activityGO:0151018.5SLC22A2, SLC22A1, SLC22A3

Products for genes affiliated with Nephropathy-Hypertension

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Sources for Nephropathy-Hypertension

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet