Nephropathy-hypertension malady

MalaCards: Nephropathy-hypertension, also known as hypertensive nephropathy, is related to hypertensive nephropathy and hypertension. An important gene associated with Nephropathy-hypertension is ACE (angiotensin I converting enzyme (peptidyl-dipeptidase A) 1). The compounds thiazide and indapamide have been mentioned in the context of this disorder.

nephropathy-hypertension 7 33 hypertensive nephropathy 43

Diseases related to nephropathy-hypertension by text searches and GeneDecks gene sharing:

(show top 50)    (show all 103)

id	Related Disease	Score	Top Affiliating Genes
1	hypertensive nephropathy	31.9	ACE, ALB
2	hypertension	30.4	RFH1, ALB, GNB3, ACE
3	essential hypertension	27.5	ACE, GNB3, ALB
4	nephropathy	26.4	RFH1, ALB, GNB3, ACE
5	aortic coarctation	12.9	GNB3, ACE
6	orthostatic hypotension	12.9	GNB3, ACE
7	carotid stenosis	12.9	ACE, GNB3
8	tardive dyskinesia	12.9	GNB3, ACE
9	hypertensive retinopathy	12.9	ALB, ACE
10	renal hypertension	12.9	ALB, ACE
11	renal vascular disease	12.9	ACE, ALB
12	focal glomerulosclerosis	12.9	ACE, ALB
13	anuria	12.9	ALB, ACE
14	syncope	12.9	GNB3, ACE
15	hepatorenal syndrome	12.8	ALB, ACE
16	chronic rapidly progressive glomerulonephritis	12.8	ALB, ACE
17	paine syndrome	12.8	GNB3, ACE
18	diabetes, type 2	12.8	ACE, ALB
19	interstitial nephritis	12.8	ACE, ALB
20	steroid-resistant nephrotic syndrome	12.8	ACE, ALB
21	renovascular hypertension	12.8	ACE, ALB
22	hypomagnesemia	12.8	ACE, ALB
23	obstructive lung disease	12.8	ACE, ALB
24	acute pyelonephritis	12.8	ACE, ALB
25	high blood pressure	12.8	ALB, ACE
26	cystinosis	12.8	ALB, ACE
27	cluster headache	12.8	GNB3, ALB
28	membranous glomerulonephritis	12.8	ALB, ACE
29	adult respiratory distress syndrome	12.8	ACE, ALB
30	nephrosis	12.8	ALB, ACE
31	peripheral vascular disease	12.8	ALB, ACE
32	rheumatic fever	12.8	ACE, ALB
33	varicocele	12.8	ACE, ALB
34	food allergy	12.8	ACE, ALB
35	sleep disorder	12.8	ACE, ALB
36	hypokalemia	12.8	ACE, ALB
37	ovarian hyperstimulation syndrome	12.8	ACE, ALB
38	pulmonary embolism	12.8	ALB, ACE
39	pyelonephritis	12.8	ACE, ALB
40	pulmonary edema	12.8	ACE, ALB
41	iga glomerulonephritis	12.8	ACE, ALB
42	end stage renal failure	12.8	ALB, ACE
43	hyperuricemia	12.8	ALB, ACE
44	focal segmental glomerulosclerosis	12.8	ACE, ALB
45	portal hypertension	12.7	ALB, ACE
46	glomerulopathy	12.7	ACE, ALB
47	arterial calcification	12.7	ALB, ACE
48	diabetic neuropathy	12.7	ALB, ACE
49	pulmonary function	12.7	ALB, ACE
50	juvenile rheumatoid arthritis	12.7	ALB, ACE

Approved drugs:

Drug clinical trials:

Articles related to nephropathy-hypertension:

id	Title	Authors	Year	Affiliating Genes
1	Predictors of cardiovascular events in patients with type 2 diabetic nephropathy and hypertension: a case for albuminuria. (15485418)	Anavekar N.S.... Pfeffer M.A.	2004	ALB
2	Nifedipine and enalapril equally reduce the progressi on of nephropathy in hypertensive type 2 diabetics. (11689274)	Baba S.	2001	ALB
3	G-Protein beta(3) subunit C825T variant, nephropathy and hypertension in patients with type 2 (Non-insulin-dependent) diabetes mellitus. (10970984)	Zychma M.J.... Grzeszczak W.	2000	GNB3
4	Genetic variants of the renin-angiotensin system, diabetic nephropathy and hypertension. (9049480)	Ringel J.... Sharma A.M.	1997	ACE
5	A comparison of spirapril and isradipine in patients with diabetic nephropathy and hypertension. (8173700)	NA... Feldt-Rasmussen B.	1993	ACE

Genes related to nephropathy-hypertension according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
2	ALB	albumin	11.0	Publications
3	RFH1	Renal failure, progressive, with hypertension	11.0
4	GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	11.0	Publications

Compounds related to nephropathy-hypertension according to GeneDecks:

(show all 23)

id	Compound	Score	Top Affiliating Genes
1	thiazide32	9.7	GNB3, ACE
2	indapamide32 9 9	11.7	ACE, ALB
3	fosinopril32 9 9	11.7	ALB, ACE
4	lisinopril32 9 18 9	12.7	ACE, ALB
5	ramipril32 9 9	11.7	ALB, ACE
6	valsartan32 42 9 9	12.7	ACE, ALB
7	perindopril32 34 9 9	12.6	ALB, ACE
8	telmisartan32 9 9	11.6	ACE, ALB
9	irbesartan32 9 9	11.6	ACE, ALB
10	nitroglycerin32 9 9	11.6	ACE, GNB3
11	candesartan32 9 9	11.6	ALB, ACE
12	enalapril32 9 9	11.6	ACE, ALB
13	amlodipine32 9 18 9	12.6	ACE, ALB
14	spironolactone32 42 34 9 9	13.6	ACE, ALB
15	furosemide32 42 34 9 18 9	14.5	ACE, ALB
16	captopril32 42 9 9	12.4	ALB, ACE
17	warfarin32 34 9 18 9	13.3	ALB, ACE
18	kininogen32	9.2	ALB, ACE
19	hydrochlorothiazide32 34 9 18 9	13.2	ACE, ALB, GNB3
20	losartan32 34 9 9	12.0	ALB, ACE
21	potassium32 9 18 9	12.0	ACE, ALB, GNB3
22	sodium32 18	9.9	ALB, ACE, GNB3
23	cholesterol32 9 18 9	11.8	ACE, GNB3, ALB

Biological processes related to nephropathy-hypertension according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of blood pressure	GO:008217	9.4	GNB3, ACE

Molecular functions related to nephropathy-hypertension according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	drug binding	GO:008144	9.3	ALB, ACE