MCID: NPH016
MIFTS: 28

Nephropathy-Hypertension malady

Nephrological diseases category

Summaries for Nephropathy-Hypertension

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32MalaCards
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MalaCards: Nephropathy-Hypertension, also known as hypertensive nephropathy, is related to hypertensive nephropathy and hypertension. An important gene associated with Nephropathy-Hypertension is RFH1 (Renal failure, progressive, with hypertension), and among its related pathways are Amine compound SLC transporters and GABA synthesis, release, reuptake and degradation. The compounds indapamide and Estropipate have been mentioned in the context of this disorder. Related mouse phenotype renal/urinary system.

Aliases & Classifications for Nephropathy-Hypertension

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Sources:
46OMIM, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

nephropathy-hypertension 46
hypertensive nephropathy 60


Related Diseases for Nephropathy-Hypertension

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Nephropathy-Hypertension:



Diseases related to nephropathy-hypertension

Clinical Features for Nephropathy-Hypertension

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Drugs & Therapeutics for Nephropathy-Hypertension

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Nephropathy-Hypertension

Search CenterWatch for Nephropathy-Hypertension

Genetic Tests for Nephropathy-Hypertension

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Anatomical Context for Nephropathy-Hypertension

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Animal Models for Nephropathy-Hypertension or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Nephropathy-Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.2ALB, ACE, SLC22A2, SLC22A1

Publications for Nephropathy-Hypertension

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Genetic Variations for Nephropathy-Hypertension

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Expression for genes affiliated with Nephropathy-Hypertension

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephropathy-Hypertension

Search GEO for disease gene expression data for Nephropathy-Hypertension.

Pathways for genes affiliated with Nephropathy-Hypertension

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Sources:
53Reactome, 49PharmGKB
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Compounds for genes affiliated with Nephropathy-Hypertension

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB, 2BitterDB, 59Tocris Bioscience
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Compounds related to Nephropathy-Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1indapamide44 1110.9ALB, ACE
2Estropipate119.7SLC22A1, ALB
3fosinopril44 1110.7ACE, ALB
4thiothixene28 1110.7ALB, SLC22A1
5Acepromazine119.7ALB, SLC22A1
6Thioproperazine119.6SLC22A1, ALB
7Pipotiazine119.6SLC22A1, ALB
8indoxyl sulfate449.5SLC22A2, ALB
9hydrochlorothiazide44 49 28 11 2413.5ALB, GNB3, ACE
10cirazoline449.5SLC22A2, SLC22A3
11Tubocurarine119.4SLC22A1, SLC22A2
12pancuronium44 28 1111.3SLC22A2, SLC22A1
13phenformin44 1110.2SLC22A2, SLC22A1
14clonidine44 28 1111.2SLC22A1, GNB3, SLC22A3
15disopyramide44 1110.2SLC22A1, SLC22A2
16moxonidine449.2ACE, SLC22A2, SLC22A3
17Aminohippurate119.0SLC22A1, SLC22A2
18chlorpheniramine44 2 11 2412.0SLC22A1, SLC22A2, ALB
19probenecid44 28 59 49 1113.0SLC22A1, SLC22A2, ALB
20moxa449.0SLC22A2, SLC22A1, SLC22A3
21Histamine Phosphate119.0SLC22A1, SLC22A3, SLC22A2
22phenoxybenzamine44 119.9SLC22A2, SLC22A3, SLC22A1
23procainamide44 119.9SLC22A1, SLC22A3, SLC22A2
24agmatine44 28 11 2411.9SLC22A1, SLC22A2, SLC22A3
251 methyl 4 phenylpyridinium448.9SLC22A1, SLC22A2, SLC22A3
26Cladribine118.9SLC22A2, SLC22A1
27prazosin44 28 49 1111.9SLC22A3, SLC22A2, SLC22A1
28lamivudine44 119.9SLC22A3, SLC22A2, SLC22A1
29guanidine44 11 2410.9SLC22A3, SLC22A1, SLC22A2
30desipramine44 49 1110.9SLC22A3, SLC22A2, SLC22A1
31tetraethylammonium44 28 1110.9SLC22A2, SLC22A3, SLC22A1
32cimetidine44 28 1110.9SLC22A3, SLC22A1, SLC22A2
33oxaliplatin44 49 1110.9SLC22A3, SLC22A2, SLC22A1
34imipramine44 49 28 11 2412.9SLC22A3, SLC22A1, SLC22A2
35nifedipine44 49 28 1111.8ACE, SLC22A2, SLC22A3
36carnitine448.8SLC22A3, SLC22A2, SLC22A1
37corticosterone44 59 2410.8SLC22A3, SLC22A2, SLC22A1
38catecholamine448.8SLC22A3, SLC22A2, SLC22A1
39metformin44 49 1110.5SLC22A2, ACE, SLC22A1, SLC22A3
40verapamil44 49 28 11 2412.5ACE, SLC22A3, SLC22A2, SLC22A1
41choline44 11 2410.5SLC22A3, SLC22A2, SLC22A1
42sodium44 249.5ACE, SLC22A2, GNB3, ALB
43acetylcholine44 49 28 11 2412.5SLC22A3, SLC22A2, ACE, SLC22A1
44histamine44 28 2410.4SLC22A3, ALB, SLC22A1, SLC22A2
45estradiol44 11 2410.4SLC22A3, SLC22A1, SLC22A2, ALB
46epinephrine44 11 2410.4GNB3, SLC22A3, SLC22A1, SLC22A2
47imatinib44 49 1110.3ALB, SLC22A2, SLC22A1
48creatinine448.1ALB, SLC22A1, ACE, SLC22A3, SLC22A2
49norepinephrine44 11 2410.0GNB3, SLC22A3, SLC22A1, SLC22A2, ACE
50glucose448.0ACE, GNB3, SLC22A1, SLC22A2, ALB

GO Terms for genes affiliated with Nephropathy-Hypertension

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Sources:
16Gene Ontology
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Biological processes related to Nephropathy-Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.5ACE, GNB3
2dopamine transportGO:0158729.3SLC22A3, SLC22A1
3drug transmembrane transportGO:0068558.6SLC22A2, SLC22A1, SLC22A3
4organic cation transportGO:0156958.6SLC22A2, SLC22A1, SLC22A3
5transmembrane transportGO:0550858.0SLC22A3, SLC22A1, SLC22A2, ALB
6small molecule metabolic processGO:0442817.2GNB3, SLC22A3, SLC22A1, SLC22A2, ALB

Molecular functions related to Nephropathy-Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1drug bindingGO:0081449.6ACE, ALB
2dopamine transmembrane transporter activityGO:0053299.0SLC22A3, SLC22A1
3secondary active organic cation transmembrane transporter activityGO:0085138.9SLC22A1, SLC22A2
4quaternary ammonium group transmembrane transporter activityGO:0156518.6SLC22A3, SLC22A1, SLC22A2
5organic cation transmembrane transporter activityGO:0151018.5SLC22A3, SLC22A1, SLC22A2

Products for genes affiliated with Nephropathy-Hypertension

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nephropathy-Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet