MCID: NPH010
MIFTS: 38

Nephrosclerosis malady

Rare diseases, Cardiovascular diseases, Nephrological diseases categories

Aliases & Classifications for Nephrosclerosis

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Aliases & Descriptions for Nephrosclerosis:

Name: Nephrosclerosis 10 45 47 65 36
 
Renal Sclerosis 10


Classifications:



External Ids:

Disease Ontology10 DOID:11664
MeSH36 D009400
ICD9CM29 587

Summaries for Nephrosclerosis

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Wikipedia:68 Hypertensive nephropathy (or \"hypertensive nephrosclerosis\", or \"Hypertensive kidney disease\") is a... more...

MalaCards based summary: Nephrosclerosis, also known as renal sclerosis, is related to renal hypertension and retinitis. An important gene associated with Nephrosclerosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways are A-beta Uptake and Degradation and Renin secretion. Affiliated tissues include kidney, pituitary and heart, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Related Diseases for Nephrosclerosis

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Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 123)
idRelated DiseaseScoreTop Affiliating Genes
1renal hypertension30.4ACE, AGTR1
2retinitis30.0CCL2, MTHFR
3kidney disease10.4
4glomerulonephritis10.4
5hemolytic-uremic syndrome10.3
6idiopathic membranous glomerulonephritis10.3ACE, AGTR1
7malignant hypertension10.3
8pyelonephritis10.3
9periarteritis nodosa10.3
10primary non-gestational choriocarcinoma of ovary10.2ACE, TGFB1
11malignant iris melanoma10.2ACE, AGTR1
12renal tubular dysgenesis10.2ACE, AGTR1
13acute pulmonary heart disease10.2CCL2, SYNPO
14chronic salpingo-oophoritis10.2ACE, AGTR1
15ladd syndrome10.2
16end stage renal failure10.2
17cerebritis10.2
18arteriosclerosis10.2
19glomerulosclerosis10.2
20ischemia10.2
21glomerular disease10.2
22open-angle glaucoma10.2ACE, AGTR1
23penis squamous cell carcinoma10.2ACE, TGFB1
24meningococcemia10.2ADRB1, AGTR1
25corneal dystrophy, fuchs endothelial, 810.2NPHS2, SYNPO
26renal pelvis carcinoma10.2ACE, AGTR1
27fibrosing mediastinitis10.2ACE, AGTR1, TGFB1
28posterior valve urethra10.2ACE, AGTR1, TGFB1
29idiopathic hypersomnolence10.2ACE, NR3C2
30gemistocytic astrocytoma10.1ACE, NR3C2
31infiltrating lipoma10.1ACE, AGTR1, TGFB1
32renal dysplasia, unilateral10.1CTGF, SYNPO
33atherosclerosis10.1
34cerebral hemorrhage10.1
35chronic kidney failure10.1
36primary hyperoxaluria10.1
37hypertensive heart disease10.1
38chronic pyelonephritis10.1
39impaired renal function disease10.1
40non-suppurative otitis media10.1
41tuberculosis10.1
42uremia10.1
43urinary system disease10.1
44aortic dissection lentiginosis10.1ACE, ADRB1, AGTR1
45miliaria rubra10.1CTGF, TGFB1
46vesicoureteral reflux10.1CTGF, TGFB1
47thrombocytopenia due to platelet alloimmunization10.1CTGF, TGFB1
48perinephritis10.1ACE, AGTR1, NR3C2
49hepatic vein thrombosis10.1ACE, AGTR1, NR3C2
50hyperglycemia10.1ACE, AGTR1, NR3C2

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to nephrosclerosis

Symptoms for Nephrosclerosis

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Drugs & Therapeutics for Nephrosclerosis

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Drugs for Nephrosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Valsartanapproved, investigationalPhase 4260137862-53-460846
Synonyms:
(2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid
(S)-N-Valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine
(S)-N-valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine
(s)-2-(n-((2'-(1h-tetrazol-5-yl)biphenyl-4-yl)methyl)pentanamido)-3-methylbutanoic acid
137862-53-4
AC-4543
AC1L1U1M
AC1Q5QIK
Ambap137862-53-4
Aventis brand of valsartan
BIDD:GT0345
BRD-K45158365-001-02-3
BSPBio_003501
Bio-0796
C081489
C24H29N5O3
CEPA brand of valsartan
CGP 48933
CGP-48933
CHEBI:9927
CHEMBL1069
CID60846
CPD000466318
D00400
DB00177
Diovan
Diovan (TN)
Diovan, Valsartan
Esteve brand of valsartan
HMS1922L21
HMS2051L12
HMS2093K22
HSDB 7519
KBio2_002287
KBio2_004855
KBio2_007423
KBio3_003006
KBioGR_001078
KBioSS_002289
Kalpress
 
L-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI)
LS-161334
Lacer brand of valsartan
MLS000759423
MLS001424088
Miten
MolPort-002-507-854
MolPort-003-666-608
N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine
N-(P-(O-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine
N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine
N-Pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine
N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-L-valine
N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine
N-valeryl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)valine
Nisis
Nisis||
Novartis brand of valsartan
Provas
S1894_Selleck
SAM001246581
SMR000466318
SPBio_001260
SPECTRUM1505209
Sanol brand of valsartan
Schwarz brand of valsartan
Spectrum2_001120
Spectrum3_001831
Spectrum4_000749
Spectrum5_001582
Spectrum_001796
TL8000869
Tareg
UNII-80M03YXJ7I
Vals
Valsarran
Valsartan
Valsartan (JAN/USAN/INN)
Valsartan [USAN:INN]
valsartan
walsartan
|Tareg
2Angiotensin II Type 1 Receptor BlockersPhase 4928
3
Angiotensin IIPhase 498568521-88-0, 11128-99-7172198
Synonyms:
1-8-Angiotensin I
1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide
Ang II
Angiotensin 2
Angiotensin II (human)
 
Angiotensin II (mouse)
Angiotonin
Asp-arg-val-TYR-ile-his-pro-phe
Human angiotensin II
Hypertensin
Ile(5)-angiotensin II
4BeraprostinvestigationalPhase 2, Phase 31488430-50-66917950
5TezosentanPhase 2, Phase 361

Interventional clinical trials:

idNameStatusNCT IDPhase
1Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney DiseaseTerminatedNCT01129557Phase 4
2TRK-100STP Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis)CompletedNCT01090037Phase 2, Phase 3
3TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis)CompletedNCT02480751Phase 2
4Renal NCE-MRI in Healthy VolunteersCompletedNCT02618460

Search NIH Clinical Center for Nephrosclerosis


Cochrane evidence based reviews: Nephrosclerosis

Genetic Tests for Nephrosclerosis

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Anatomical Context for Nephrosclerosis

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MalaCards organs/tissues related to Nephrosclerosis:

33
Kidney, Pituitary, Heart, Pancreas, Bone, Smooth muscle, Endothelial

Animal Models for Nephrosclerosis or affiliated genes

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MGI Mouse Phenotypes related to Nephrosclerosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.9ACE, AGTR1, BMP5, NPHS2, NR3C2, SYNPO
2MP:00053856.8ACE, ADRB1, AGTR1, BMP5, CCL2, CTGF
3MP:00053766.3ACE, ADRB1, AGTR1, CCL2, CTGF, MTHFR
4MP:00107685.8ACE, ADRB1, AGTR1, BMP5, CCL2, CTGF
5MP:00053785.7ACE, ADRB1, AGTR1, BMP5, CCL2, CTGF

Publications for Nephrosclerosis

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Articles related to Nephrosclerosis:

(show top 50)    (show all 257)
idTitleAuthorsYear
1
Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis. (23151750)
2013
2
Castleman's disease accompanied by hypolipidemic cerebral hemorrhage and nephrosclerosis. (23857095)
2013
3
Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis. (22236281)
2012
4
The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. (21319131)
2011
5
Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. (21080950)
2010
6
The association between age and nephrosclerosis on renal biopsy among healthy adults. (20439574)
2010
7
Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. (19745105)
2009
8
Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease in TGF-beta(1). (17998773)
2007
9
Hypertensive nephrosclerosis. (16988752)
2006
10
Dr. Yang Nizhi's experience in treating benign arteriolar nephrosclerosis. (16705856)
2006
11
Hypertensive nephrosclerosis: update. (15202608)
2004
12
Stent angioplasty of severe atherosclerotic ostial renal artery stenosis in patients with diabetes mellitus and nephrosclerosis. (12652503)
2003
13
Hypertensive nephrosclerosis in African Americans versus Caucasians. (12081576)
2002
14
Nipradilol prevents L-NAME-exacerbated nephrosclerosis with decreasing of caspase-3 expression in SHR. (12135323)
2002
15
A 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor reduces hypertensive nephrosclerosis in stroke-prone spontaneously hypertensive rats. (12473872)
2002
16
Cytochrome c mediates apoptosis in hypertensive nephrosclerosis in Dahl/Rapp rats. (11168948)
2001
17
Intrauterine food restriction as a determinant of nephrosclerosis. (11228169)
2001
18
Cilnidipine is as effective as benazepril for control of blood pressure and proteinuria in hypertensive patients with benign nephrosclerosis. (11510750)
2001
19
Hypertensive nephrosclerosis pathogenesis, diagnosis and management. (18212435)
1999
20
The clinical diagnosis of hypertensive nephrosclerosis--how reliable is it? (10069175)
1999
21
Progression of renal failure and hypertensive nephrosclerosis. (9839285)
1998
22
Accuracy of the diagnosis of hypertensive nephrosclerosis in African Americans: a report from the African American Study of Kidney Disease (AASK) Trial. AASK Pilot Study Investigators. (8995739)
1997
23
Hydrochlorothiazide exacerbates nitric oxide-blockade nephrosclerosis with glomerular hypertension in spontaneously hypertensive rats. (8818920)
1996
24
Immunohistochemical analysis of type III and IV collagens in tubulointerstitial damage in human benign nephrosclerosis. (8746616)
1995
25
Effects of novel, nonpeptide vasopressin antagonists on progressive nephrosclerosis in rats. (7630164)
1995
26
Hypertensive nephrosclerosis in the Dahl/Rapp rat. Initial sites of injury and effect of dietary L-arginine supplementation. (8441251)
1993
27
Clinical features of benign hypertensive nephrosclerosis at time of renal biopsy. (8327642)
1993
28
Cholinergic vasodilatory effect of an imidazoindole on the nephrosclerosis of hypertensive rats. (2383253)
1990
29
Decompensated benign nephrosclerosis and secondary malignant nephrosclerosis. (3720032)
1986
30
Proteinuria in benign nephrosclerosis. (3729631)
1986
31
Marked proteinuria in hypertensive nephrosclerosis. (3160240)
1985
32
Glomerular injury in malignant nephrosclerosis. (740104)
1978
33
Pathology of malignant nephrosclerosis with special reference to the difference between histologic manifestations of pure and exacerbated forms. (694919)
1978
34
Nephrosclerosis postpartum and in women taking oral contraceptives. (1247349)
1976
35
Malignant nephrosclerosis during pregnancy and in the postpartum period (the uremic hemolytic syndrome). (779474)
1976
36
Asymmetrical interlobar nephrosclerosis. (4131975)
1974
37
Bilateral nephrectomy and renal homotransplantation for malignant nephrosclerosis. (4576897)
1973
38
The role of nephrosclerosis in separate function tests. (5444314)
1970
39
RHEUMATIC NEPHROSCLEROSIS WITH SPECIAL REFERENCE TO RHEUMATIC ENDARTERITIS. (14297514)
1965
40
IMMUNOCYTOCHEMICAL OBSERVATIONS ON THE VASCULAR NECROSIS AND RENAL GLOMERULAR LESIONS OF MALIGNANT NEPHROSCLEROSIS. (14328020)
1965
41
MALIGNANT HYPERTENSION, MALIGNANT NEPHROSCLEROSIS, AND SYSTEMIC VASCULITIS. (14303079)
1965
42
Radiation nephrosclerosis. (13725173)
1960
43
The hormonal production of nephrosclerosis and periarteritis nodosa in the primate. (13383223)
1957
44
CLINICO-PATHOLOGICAL conference: large fibromyomata uteri with hypertensive heart disease and arteriolar nephrosclerosis. (13086088)
1953
45
Malignant nephrosclerosis without retinal edema in a child; long-term observations and renal function studies. (14902103)
1952
46
VA clinical pathological conference: cerebral hemorrhage associated with malignant nephrosclerosis and cardiac hypertrophy. (13013101)
1952
47
Unilateral renal cortical necrosis and unilateral benign and malignant nephrosclerosis, associated with contralateral renal artery occlusion: report of a case. (14789332)
1951
48
Nephrosclerosis]. (20271308)
1947
49
Nephrosclerosis, benign and malignant. (20293863)
1947
50
Benign and Malignant Hypertension and Nephrosclerosis: A Clinical and Pathological Study. (19970253)
1936

Variations for Nephrosclerosis

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Expression for genes affiliated with Nephrosclerosis

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Search GEO for disease gene expression data for Nephrosclerosis.

Pathways for genes affiliated with Nephrosclerosis

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Pathways related to Nephrosclerosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ACE, CCL2
29.4ACE, ADRB1, AGTR1
39.1BMP5, CTGF, TGFB1
4
Show member pathways
9.0ACE, AGTR1, NR3C2, TGFB1
5
Show member pathways
8.2ACE, AGTR1, BMP5, CCL2, CTGF, TGFB1

GO Terms for genes affiliated with Nephrosclerosis

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Biological processes related to Nephrosclerosis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by renin-angiotensinGO:000308110.5ACE, AGTR1
2mononuclear cell proliferationGO:003294310.5ACE, TGFB1
3regulation of vasodilationGO:004231210.3ACE, AGTR1
4regulation of vasoconstrictionGO:001922910.3ACE, AGTR1
5lipopolysaccharide-mediated signaling pathwayGO:003166310.1CCL2, TGFB1
6protein kinase B signalingGO:004349110.1CCL2, TGFB1
7response to progesteroneGO:003257010.1CCL2, TGFB1
8positive regulation of cellular protein metabolic processGO:003227010.0AGTR1, TGFB1
9cellular response to dexamethasone stimulusGO:00715499.8CCL2, TGFB1
10excretionGO:00075889.7NPHS2, NR3C2
11positive regulation of collagen biosynthetic processGO:00329679.7CCL2, CTGF, TGFB1
12response to woundingGO:00096119.5CCL2, CTGF, TGFB1
13response to amino acidGO:00432008.7CCL2, CTGF, MTHFR
14response to hypoxiaGO:00016668.7CCL2, MTHFR, TGFB1

Molecular functions related to Nephrosclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:003171110.4ACE, AGTR1
2growth factor activityGO:00080839.1BMP5, CTGF, TGFB1

Sources for Nephrosclerosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet