MCID: NPH010
MIFTS: 43

Nephrosclerosis malady

Rare diseases, Nephrological diseases categories

Aliases & Classifications for Nephrosclerosis

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Nephrosclerosis, Aliases & Descriptions:

Name: Nephrosclerosis 9 41 43 60
 
Renal Sclerosis 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:11664
ICD9CM27 587
MeSH33 D009400

Summaries for Nephrosclerosis

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Wikipedia:63 Hypertensive nephropathy (or \"hypertensive nephrosclerosis\", or \"Hypertensive kidney disease\") is a... more...

MalaCards based summary: Nephrosclerosis, also known as renal sclerosis, is related to malignant hypertension and glomerulonephritis. An important gene associated with Nephrosclerosis is ADM (adrenomedullin), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Mitotic Roles of Polo Like Kinases. The compounds temocaprilat and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include kidney, pituitary and heart, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Related Diseases for Nephrosclerosis

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Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1malignant hypertension30.7ACE, ADM
2glomerulonephritis30.4TGFB1, AGTR1
3renal hypertension30.2ACE, ADM
4kidney disease30.2AGTR1, NR3C2, TGFB1
5hypertensive heart disease30.1AGTR1, NR3C2, ACE
6renovascular hypertension30.0ADM, AGTR1, ACE
7hyperaldosteronism29.8ACE, AGTR1, NR3C2
8glomerulosclerosis29.8AGTR1, ACE, ADM, TGFB1
9proteinuria29.7TGFB1, ADM, ACE, AGTR1, NR3C2
10atherosclerosis29.5TGFB1, NR3C2, AGTR1, ACE
11iga glomerulonephritis29.5TGFB1, ADM, ACE, AGTR1
12anuria10.4ACE
13urinary tract obstruction10.4ACE
14oligohydramnios10.4ACE
15hemolytic-uremic syndrome10.3
16pyelonephritis10.2
17periarteritis nodosa10.2
18renal tubular dysgenesis10.2AGTR1, ACE
19adrenocortical carcinoma10.2AGTR1, ADM
20ladd syndrome10.2
21cerebritis10.2
22arteriosclerosis10.2
23ischemia10.2
24uremia10.2
25adrenal cortical adenoma10.2AGTR1, ADM
26focal segmental glomerulosclerosis10.2AGTR1, ACE
27stroke, ischemic10.1ACE, ADM
28familial hyperlipidemia10.1AGTR1, ACE
29cerebral hemorrhage10.1
30progeria10.1
31chronic pyelonephritis10.1
32tuberculosis10.1
33sudden cardiac death multi-gene panels10.1ACE, NR3C2
34hypercholesterolemia, familial10.1ACE, AGTR1
35hypokalemia10.1ACE, NR3C2
36ureteral obstruction10.1TGFB1, AGTR1
37vitreoretinopathy, neovascular inflammatory10.0ADM, TGFB1
38cerebrovascular disease10.0ADM, AGTR1, ACE
39microvascular complications of diabetes 510.0AGTR1, ACE, ADM
40coronary artery disease10.0ACE, ADM, AGTR1
41conn's syndrome10.0AGTR1, ADM, NR3C2
42noonan syndrome 110.0ACE, AGTR1
43idiopathic edema10.0ADM, ACE, NR3C2
44pulmonary fibrosis10.0AGTR1, TGFB1
45preeclampsia/eclampsia 110.0ADM, NR3C2, AGTR1
46atrial fibrillation9.9ACE, NR3C2, AGTR1
47nephrosis9.9
48hypertensive nephropathy9.9
49obesity9.9
50multiple myeloma9.9

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to nephrosclerosis

Symptoms for Nephrosclerosis

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Drugs & Therapeutics for Nephrosclerosis

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Drug clinical trials:

Search ClinicalTrials for Nephrosclerosis

Search NIH Clinical Center for Nephrosclerosis

Genetic Tests for Nephrosclerosis

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Anatomical Context for Nephrosclerosis

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MalaCards organs/tissues related to Nephrosclerosis:

31
Kidney, Pituitary, Heart, Bone, Smooth muscle, Pancreas, Spleen, Testes, Endothelial

Animal Models for Nephrosclerosis or affiliated genes

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MGI Mouse Phenotypes related to Nephrosclerosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.8AGTR1, NR3C2, ACE, ADM, TGFB1
2MP:00053857.8TGFB1, ADM, ACE, NR3C2, AGTR1
3MP:00053877.7TGFB1, ADM, ACE, UBD, AGTR1
4MP:00053977.6UBD, NR3C2, ACE, ADM, TGFB1
5MP:00107687.6AGTR1, NR3C2, ACE, ADM, TGFB1
6MP:00053847.5UBD, NR3C2, ACE, ADM, TGFB1
7MP:00053767.3TGFB1, ADM, ACE, NR3C2, AGTR1

Publications for Nephrosclerosis

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Articles related to Nephrosclerosis:

(show top 50)    (show all 259)
idTitleAuthorsYear
1
Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis. (23151750)
2013
2
Castleman's disease accompanied by hypolipidemic cerebral hemorrhage and nephrosclerosis. (23857095)
2013
3
Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis. (22236281)
2012
4
The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. (21319131)
2011
5
Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. (21080950)
2010
6
The association between age and nephrosclerosis on renal biopsy among healthy adults. (20439574)
2010
7
Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. (19745105)
2009
8
Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease in TGF-beta(1). (17998773)
2007
9
Hypertensive nephrosclerosis. (16988752)
2006
10
Dr. Yang Nizhi's experience in treating benign arteriolar nephrosclerosis. (16705856)
2006
11
Hypertensive nephrosclerosis: update. (15202608)
2004
12
Stent angioplasty of severe atherosclerotic ostial renal artery stenosis in patients with diabetes mellitus and nephrosclerosis. (12652503)
2003
13
Hypertensive nephrosclerosis in African Americans versus Caucasians. (12081576)
2002
14
Nipradilol prevents L-NAME-exacerbated nephrosclerosis with decreasing of caspase-3 expression in SHR. (12135323)
2002
15
A 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor reduces hypertensive nephrosclerosis in stroke-prone spontaneously hypertensive rats. (12473872)
2002
16
Cytochrome c mediates apoptosis in hypertensive nephrosclerosis in Dahl/Rapp rats. (11168948)
2001
17
Intrauterine food restriction as a determinant of nephrosclerosis. (11228169)
2001
18
Cilnidipine is as effective as benazepril for control of blood pressure and proteinuria in hypertensive patients with benign nephrosclerosis. (11510750)
2001
19
Hypertensive nephrosclerosis pathogenesis, diagnosis and management. (18212435)
1999
20
The clinical diagnosis of hypertensive nephrosclerosis--how reliable is it? (10069175)
1999
21
Progression of renal failure and hypertensive nephrosclerosis. (9839285)
1998
22
Accuracy of the diagnosis of hypertensive nephrosclerosis in African Americans: a report from the African American Study of Kidney Disease (AASK) Trial. AASK Pilot Study Investigators. (8995739)
1997
23
Hydrochlorothiazide exacerbates nitric oxide-blockade nephrosclerosis with glomerular hypertension in spontaneously hypertensive rats. (8818920)
1996
24
Immunohistochemical analysis of type III and IV collagens in tubulointerstitial damage in human benign nephrosclerosis. (8746616)
1995
25
Effects of novel, nonpeptide vasopressin antagonists on progressive nephrosclerosis in rats. (7630164)
1995
26
Hypertensive nephrosclerosis in the Dahl/Rapp rat. Initial sites of injury and effect of dietary L-arginine supplementation. (8441251)
1993
27
Clinical features of benign hypertensive nephrosclerosis at time of renal biopsy. (8327642)
1993
28
Cholinergic vasodilatory effect of an imidazoindole on the nephrosclerosis of hypertensive rats. (2383253)
1990
29
Quantitation of hypertensive nephrosclerosis on an objective rational scale of measure in adults and children. (3751980)
1986
30
Proteinuria in benign nephrosclerosis. (3729631)
1986
31
Marked proteinuria in hypertensive nephrosclerosis. (3160240)
1985
32
Glomerular injury in malignant nephrosclerosis. (740104)
1978
33
Pathology of malignant nephrosclerosis with special reference to the difference between histologic manifestations of pure and exacerbated forms. (694919)
1978
34
Nephrosclerosis postpartum and in women taking oral contraceptives. (1247349)
1976
35
Asymmetrical interlobar nephrosclerosis. (4131975)
1974
36
Bilateral nephrectomy and renal homotransplantation for malignant nephrosclerosis. (4576897)
1973
37
The role of nephrosclerosis in separate function tests. (5444314)
1970
38
RHEUMATIC NEPHROSCLEROSIS WITH SPECIAL REFERENCE TO RHEUMATIC ENDARTERITIS. (14297514)
1965
39
IMMUNOCYTOCHEMICAL OBSERVATIONS ON THE VASCULAR NECROSIS AND RENAL GLOMERULAR LESIONS OF MALIGNANT NEPHROSCLEROSIS. (14328020)
1965
40
MALIGNANT HYPERTENSION, MALIGNANT NEPHROSCLEROSIS, AND SYSTEMIC VASCULITIS. (14303079)
1965
41
Radiation nephrosclerosis. (13725173)
1960
42
The hormonal production of nephrosclerosis and periarteritis nodosa in the primate. (13383223)
1957
43
CLINICO-PATHOLOGICAL conference: large fibromyomata uteri with hypertensive heart disease and arteriolar nephrosclerosis. (13086088)
1953
44
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952
45
Malignant nephrosclerosis without retinal edema in a child; long-term observations and renal function studies. (14902103)
1952
46
VA clinical pathological conference: cerebral hemorrhage associated with malignant nephrosclerosis and cardiac hypertrophy. (13013101)
1952
47
Unilateral renal cortical necrosis and unilateral benign and malignant nephrosclerosis, associated with contralateral renal artery occlusion: report of a case. (14789332)
1951
48
Nephrosclerosis]. (20271308)
1947
49
Nephrosclerosis, benign and malignant. (20293863)
1947
50
Benign and Malignant Hypertension and Nephrosclerosis: A Clinical and Pathological Study. (19970253)
1936

Variations for Nephrosclerosis

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Expression for genes affiliated with Nephrosclerosis

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Search GEO for disease gene expression data for Nephrosclerosis.

Pathways for genes affiliated with Nephrosclerosis

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Pathways related to Nephrosclerosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
9.1TGFB1, ACE
29.1UBD, TGFB1
3
Show member pathways
8.7AGTR1, ACE, TGFB1
4
Show member pathways
8.7UBD, TGFB1, AGTR1
5
Show member pathways
8.1TGFB1, ACE, NR3C2, AGTR1

Compounds for genes affiliated with Nephrosclerosis

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Compounds related to Nephrosclerosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1temocaprilat439.9ACE, AGTR1
2aliskiren43 1210.9ACE, AGTR1
3lacidipine439.9AGTR1, ACE
4angiotensin ii28 2410.8AGTR1, ACE
5omapatrilat439.8ADM, ACE
6saralasin439.8AGTR1, ACE
7eprosartan43 28 1211.8AGTR1, ACE
8cilazapril43 1210.8AGTR1, ACE
9trandolapril43 1210.8AGTR1, ACE
10pd12331943 2810.7ACE, AGTR1
11bradykinin59 28 2411.7AGTR1, ACE
12olmesartan43 28 1211.7ACE, AGTR1
13triamterene43 24 1211.7ACE, NR3C2
14fosinopril43 1210.6AGTR1, ACE
15doxazosin43 1210.5AGTR1, ACE, ADM
16quinapril43 49 1211.5AGTR1, ACE
17carvedilol43 49 28 1212.5ADM, ACE, AGTR1
18nitroglycerin43 1210.5ADM, AGTR1, ACE
19aldosterone28 24 1211.4NR3C2, AGTR1, ADM
20catecholamine439.3ADM, NR3C2, AGTR1
21eplerenone43 59 28 1212.3NR3C2, ACE, AGTR1
22thiazide439.3AGTR1, ACE, NR3C2
23felodipine43 28 1211.3NR3C2, ACE, AGTR1
24hydrochlorothiazide43 28 49 24 1213.3ACE, NR3C2, AGTR1
25enalapril43 49 1211.3ACE, AGTR1, NR3C2
26spironolactone43 59 28 49 1213.3NR3C2, AGTR1, ACE
27prostacyclin439.2ADM, ACE, AGTR1
28sodium nitroprusside439.1AGTR1, ADM, TGFB1
29benazepril43 49 1211.1TGFB1, ACE, AGTR1
30ramipril43 1210.1ACE, TGFB1, AGTR1
31perindopril43 49 1211.1AGTR1, ACE, TGFB1
32candesartan43 49 28 1212.1TGFB1, ACE, AGTR1
33verapamil43 28 49 24 1213.0AGTR1, TGFB1, ACE
34nifedipine43 28 49 1212.0TGFB1, ACE, AGTR1
35captopril43 59 49 28 1212.9AGTR1, NR3C2, ACE, ADM
36norepinephrine43 24 1210.9ADM, NR3C2, ACE, AGTR1
37potassium43 24 1210.9AGTR1, NR3C2, ACE, ADM
38sodium43 249.8NR3C2, ACE, AGTR1, ADM
39cholesterol43 28 24 1211.8NR3C2, ACE, ADM, AGTR1
40acth438.7AGTR1, ADM, NR3C2
41tacrolimus43 49 1210.6AGTR1, TGFB1, NR3C2
42actinomycin d438.6NR3C2, TGFB1, AGTR1, ADM
43cyclosporin a43 28 5910.5AGTR1, NR3C2, ADM, TGFB1
44cycloheximide438.5NR3C2, AGTR1, ADM, TGFB1
45dexamethasone43 49 28 1211.4ADM, TGFB1, NR3C2, AGTR1
46nitric oxide43 24 1210.4ACE, ADM, AGTR1, NR3C2
47alanine438.2AGTR1, TGFB1, NR3C2, ADM
48ang ii438.1TGFB1, NR3C2, ACE, AGTR1, ADM
49losartan43 49 28 1211.1NR3C2, ACE, ADM, TGFB1, AGTR1
50creatinine438.1TGFB1, AGTR1, ADM, ACE, NR3C2

GO Terms for genes affiliated with Nephrosclerosis

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Biological processes related to Nephrosclerosis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.8AGTR1, ACE
2regulation of vasodilationGO:00423129.7AGTR1, ACE
3regulation of vasoconstrictionGO:00192299.7AGTR1, ACE
4positive regulation of cellular protein metabolic processGO:00322709.4TGFB1, AGTR1
5mononuclear cell proliferationGO:00329439.4ACE, TGFB1
6kidney developmentGO:00018229.4AGTR1, ACE
7organ regenerationGO:00311009.4ADM, TGFB1
8response to woundingGO:00096119.3ADM, TGFB1
9positive regulation of cytosolic calcium ion concentrationGO:00072049.3AGTR1, ADM
10myeloid dendritic cell differentiationGO:00430119.3UBD, TGFB1
11female pregnancyGO:00075659.2TGFB1, ADM
12agingGO:00075689.2ADM, TGFB1
13positive regulation of apoptotic processGO:00430658.9TGFB1, ADM, UBD

Molecular functions related to Nephrosclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:00317119.2AGTR1, ACE
2protein bindingGO:00055157.1AGTR1, UBD, NR3C2, ACE, ADM, TGFB1

Products for genes affiliated with Nephrosclerosis

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Sources for Nephrosclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet