Nephrosclerosis malady

Wikipedia: Hypertensive nephropathy (or \"hypertensive nephrosclerosis\", or \"Hypertensive renal disease\") is a...⁴⁴ more...

MalaCards: Nephrosclerosis, also known as renal sclerosis unspecified (disorder), is related to hypertension and proteinuria. An important gene associated with Nephrosclerosis is ADM (adrenomedullin), and among its related pathways are ACE Inhibitor Pathway, Pharmacodynamics and Renin-angiotensin system. The compounds sp 600125 and glucose have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle and kidney, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Aliases & Descriptions:

nephrosclerosis 6 30 32 43 renal sclerosis unspecified (disorder) 6 renal sclerosis nos (disorder) 6

renal sclerosis, unspecified 6 nephrosclerosis (disorder) 6 renal sclerosis 6

Diseases related to nephrosclerosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 508)

id	Related Disease	Score	Top Affiliating Genes
1	hypertension	23.6	SERPINC1, SERPINE1, LPA, BMP7, UBD, LCAT
2	proteinuria	22.1	SERPINC1, SERPINE1, LPA, BMP7, LCAT, MPO
3	anemia	21.3	SERPINC1, BMP7, LCAT, MTHFR, MPO, INS
4	glomerulonephritis	21.1	SERPINC1, SERPINE1, LPA, LCAT, MTHFR, MPO
5	renal tubular dysgenesis	13.6	ACE, AGTR1
6	renovascular hypertension	13.6	ACE, AGTR1, ADM
7	anuria	13.6	NR3C2, ACE, AGTR1
8	conn's syndrome	13.6	NR3C2, AGTR1, ADM
9	malignant hypertension	13.6	ACE, ADAMTS13, ADM
10	hypertensive heart disease	13.6	NR3C2, ACE, AGTR1
11	oligohydramnios	13.6	ACE, AGTR1, ADM
12	aortic coarctation	13.6	ACE, AGTR1, ADRB1
13	coronary artery disease, modifier of	13.6	CCL2, ACE
14	focal segmental glomerulosclerosis	13.5	ACE, AGTR1, SYNPO
15	otosclerosis	13.5	ACE, AGTR1, TGFB1
16	sprinting performance	13.5	ACE, HIF1A
17	posterior urethral valves	13.5	ACE, ACE2, AGTR1, TGFB1
18	sudden cardiac death multi-gene panels	13.5	NR3C2, ACE, ADRB1
19	neurocirculatory asthenia	13.4	ACE, AGTR1, TGFB1
20	orthostatic hypotension	13.4	CALCA, ACE, AGTR1
21	catecholaminergic polymorphic ventricular tachycardia	13.4	ACE, ACE2, ADRB1
22	usual interstitial pneumonia	13.4	CCL2, AGTR1, TGFB1
23	obstructive lung disease	13.4	CALCA, ACE, TGFB1
24	hypoalphalipoproteinemia	13.4	LPA, LCAT, ACE
25	acute mountain sickness	13.4	ACE, HIF1A, AGTR1
26	hyporeninemic hypoaldosteronism	13.3	INS, ACE
27	complex regional pain syndrome	13.3	CALCA, ACE, TGFB1
28	systolic heart failure	13.3	MPO, NR3C2, ACE
29	congestive heart failure	13.3	NR3C2, ACE, AGTR1, ADM, ADRB1
30	carotid artery disease	13.3	LPA, CCL2, ACE
31	neurogenic hypertension	13.3	INS, ACE2
32	gingival overgrowth	13.3	CTGF, ACE, THBS1, TGFB1
33	thyroid cancer, anaplastic	13.3	BMP7, CALCA, TGFB1
34	erythrocytosis	13.2	ACE, HIF1A, AGTR1
35	critical limb ischemia	13.2	ACE, HIF1A, THBS1
36	type 1 von willebrand disease	13.2	MTHFR, ADAMTS13
37	aortic atherosclerosis	13.2	LCAT, MPO, ACE
38	pulmonary plasma cell granuloma	13.2	CTGF, TGFB1, SYNPO
39	norum disease	13.2	LPA, LCAT
40	uterine fibroid	13.2	CTGF, THBS1, ADM
41	adrenocortical carcinoma	13.2	BMP5, CALCA, AGTR1, ADM
42	marfan syndrome	13.2	MTHFR, AGTR1, TGFB1
43	androgenetic alopecia	13.2	INS, NR3C2, TGFB1
44	diabetes, type 2	13.2	INS, ACE, AGTR1
45	breast cyst	13.2	CALCA, ACE, TGFB1, ADAMTSL1
46	aneurysm disease	13.2	LPA, MTHFR, ACE
47	rapidly progressive glomerulonephritis	13.2	MPO, CCL2, TGFB1
48	iga glomerulonephritis	13.2	CCL2, ACE, AGTR1, TGFB1, ADM
49	gastric cardia adenocarcinoma	13.2	MTHFR, THBS1, TGFB1
50	ureteral disease	13.2	BMP7, CCL2, CTGF, TGFB1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to nephrosclerosis:

²²

MGI Mouse Phenotypes related to nephrosclerosis:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.6	ADAMTS13
2	endocrine/exocrine gland phenotype	MP:0005379	10.3	BMP5
3	respiratory system phenotype	MP:0005388	9.9	ACE2, CALCA, BMP5
4	reproductive system phenotype	MP:0005389	9.4	TGFB1, THBS1, CCL2, BMP7
5	embryogenesis phenotype	MP:0005380	9.4	SERPINC1, BMP5, F2
6	integument phenotype	MP:0010771	9.2	CALCA, F2, F3
7	immune system phenotype	MP:0005387	9.0	ADM, ADAMTS13, THBS1, AGTR1, F2, BMP5
8	liver/biliary system phenotype	MP:0005370	8.9	SERPINC1, BMP5, LCAT, INS, HIF1A, ADM
9	renal/urinary system phenotype	MP:0005367	8.0	ADM, SYNPO, THBS1, AGTR1, HIF1A, ACE2
10	muscle phenotype	MP:0005369	7.9	ADRB1, ADM, TGFB1, THBS1, HIF1A, ACE2
11	skeleton phenotype	MP:0005390	7.9	ADRB1, THBS1, HIF1A, CTGF, CALCA, INS
12	tumorigenesis	MP:0002006	7.8	TGFB1, THBS1, HIF1A, ACE, F3, CCL2
13	behavior/neurological phenotype	MP:0005386	7.7	ADM, SYNPO, ACE, NR3C2, CALCA, F3
14	digestive/alimentary phenotype	MP:0005381	7.0	TGFB1, THBS1, HIF1A, CTGF, F2, CCL2
15	growth/size phenotype	MP:0005378	7.0	ADRB1, THBS1, AGTR1, HIF1A, ACE, NR3C2
16	vision/eye phenotype	MP:0005391	6.9	TGFB1, THBS1, HIF1A, CTGF, F3, CCL2
17	cellular phenotype	MP:0005384	6.4	TGFB1, THBS1, HIF1A, ACE2, ACE, CTGF
18	mortality/aging	MP:0010768	6.3	ACE, ACE2, AGTR1, ADAMTS13, ADM, ADRB1
19	nervous system phenotype	MP:0003631	5.8	CALCA, NR3C2, HIF1A, TGFB1, SYNPO, F2
20	cardiovascular system phenotype	MP:0005385	4.3	SERPINC1, NR3C2, ACE, ACE2, HIF1A, AGTR1
21	homeostasis/metabolism phenotype	MP:0005376	4.1	ACE, ACE2, HIF1A, AGTR1, THBS1, TGFB1

Articles related to nephrosclerosis:

(show all 24)

id	Title	Authors	Year	Affiliating Genes
1	Expression of ACE and ACE2 in patients with hypertens ive nephrosclerosis. (21346373)	Wang G.... Szeto C.C.	2011	ACE2, ACE
2	Involvement of connective tissue growth factor in hum an and experimental hypertensive nephrosclerosis. (20689330)	Ito Y.... Goldschmeding R.	2011	CTGF
3	The role of bone morphogenetic protein-5 (BMP-5) in h uman nephrosclerosis. (21319131)	Bramlage C.P.... Strutz F.	2011	BMP5
4	ADAMTS13--marker of contractile phenotype of arterial smooth muscle cells lost in benign nephrosclerosis. (20923926)	Bockmeyer C.L.... Becker J.U.	2011	ADAMTS13
5	Bone morphogenetic protein (BMP)-7 expression is decr eased in human hypertensive nephrosclerosis. (21080950)	Bramlage C.P.... MA1ller G.A.	2010	BMP7
6	Podocyte loss in human hypertensive nephrosclerosis. (19131934)	Wang G.... Szeto C.C.	2009	SYNPO
7	Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. (19745105)	Fung M.M.... O'Connor D.T.	2009	ADRB1
8	Molecular factors of angiogenesis in renal tissue of patients with chronic glomerulonephritis: association with nephrosclerosis and anemia (19799194)	Shvetsov M.I.u.... Rameeva A.S.	2009	HIF1A, THBS1, ADAMTSL1
9	Functional polymorphism of the myeloperoxidase gene in hypertensive nephrosclerosis dialysis patients. (18344624)	Doi K.... Fujita T.	2007	MPO
10	Effects of renin-angiotensin system blockade on macrophage infiltration in patients with hypertensive nephrosclerosis. (17785932)	Imakiire T.... Miura S.	2007	CCL2, AGTR1
11	Porphyria syndrome associated with diabetic nephrosclerosis and erythropoietin. (17435269)	Hedger R.W.... French A.V.	2006	ALAD
12	The MTHFR 677TT and 677CT/1298AC genotypes in Cypriot patients may be predisposing to hypertensive nephrosclerosis and chronic renal failure. (16158041)	Koupepidou P.... Pierides A.	2005	MTHFR
13	ACE inhibition is effective and renoprotective in hypertensive nephrosclerosis: the African American Study of Kidney Disease and Hypertension (AASK) trial. (12864879)	Douglas J.G.... Agodoa L.	2003	ACE
14	Cilnidipine is as effective as benazepril for control of blood pressure and proteinuria in hypertensive patients with benign nephrosclerosis. (11510750)	Rose G.W.... Suzuki H.	2001	ACE
15	ACE inhibitors and appearance of renal events in hypertensive nephrosclerosis. (11566948)	Segura J.... Ruilope L.M.	2001	ACE
16	Mechanisms in nephrosclerosis and hypertension-beyond hemodynamics. (11798148)	Fogo A.B.	2001	SERPINE1
17	Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial. (11386927)	Agodoa L.Y.... Xu S.	2001	ACE
18	Increased fibrinogen levels and hemostatic abnormalities in patients with arteriolar nephrosclerosis: association with cardiovascular events. (11057851)	Sechi L.A.... De Marchi S.	2000	F2, SERPINC1, F3
19	Hormonal disorders in patients with chronic pyelonep hritis with nephrosclerosis and kidney failure (9621641)	Pavlov S.B.	1998	CALCA
20	Nephrosclerosis and hypertension. (9356598)	Ono H.... Ono Y.	1997	ACE
21	Possible relationship between hyperinsulinemia and gl omerular hypertrophy in nephrosclerosis. (8723365)	Hotta O.... Furuta T.	1996	INS
22	Significance of increased accumulation of type VI collagen and transforming growth factor beta 1 in tubulointerstitial damage in hypertensive nephrosclerosis: an immunohistochemical study. (8737230)	Razzaque M.S.... Taguchi T.	1996	TGFB1
23	The role of lipids in nephrosclerosis and glomerulosclerosis. (7945552)	GrAPne E.F.... Seidel D.	1994	LCAT, LPA
24	Reversible renal insufficiency due to angiotensin converting enzyme inhibitors in hypertensive nephrosclerosis. (1883120)	Toto R.D.... Pettinger W.A.	1991	ACE

Genes related to nephrosclerosis according to GeneCards:

(show all 28)

id	Symbol	Description	Score	GeneCards Section Context
1	ADM	adrenomedullin	11.0
2	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
3	AGTR1	angiotensin II receptor, type 1	11.0	Publications
4	NR3C2	nuclear receptor subfamily 3, group C, member 2	11.0
5	TGFB1	transforming growth factor, beta 1	11.0	Publications
6	UBD	ubiquitin D	11.0	Functions
7	SYNPO	synaptopodin	11.0	Publications
8	ALAD	aminolevulinate dehydratase	11.0	Publications
9	ACE2	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2	11.0	Publications
10	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif, 13	11.0	Publications
11	ADRB1	adrenoceptor beta 1	11.0	Publications
12	BMP5	bone morphogenetic protein 5	11.0	Publications
13	LCAT	lecithin-cholesterol acyltransferase	11.0	Publications
14	CTGF	connective tissue growth factor	11.0	Publications
15	BMP7	bone morphogenetic protein 7	11.0	Publications
16	THBS1	thrombospondin 1	11.0	Publications
17	LPA	lipoprotein, Lp(a)	11.0	Publications
18	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
19	MPO	myeloperoxidase	11.0	Publications
20	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
21	ADAMTSL1	ADAMTS-like 1	11.0	Publications
22	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
23	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
24	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
25	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0	Publications
26	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
27	F2	coagulation factor II (thrombin)	11.0	Publications
28	INS	insulin	11.0	Publications

Pathways related to nephrosclerosis according to GeneDecks:

(show all 20)

id	Pathway	Score	Top Affiliating Genes
1	ACE Inhibitor Pathway, Pharmacodynamics34	10.3	NR3C2, AGTR1, ACE2
2	Renin-angiotensin system20	10.2	ACE, ACE2, AGTR1
3	PGC1Alpha Pathway36	10.1	BMP5, BMP7
4	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	10.0	TGFB1, AGTR1, ACE2, ACE, NR3C2
5	TGF-beta signaling pathway20	9.8	BMP5, BMP7, THBS1, TGFB1
6	NF-KappaB (p50-p65) Pathway36	9.7	TGFB1, CTGF, UBD, BMP7, BMP5
7	Apoptotic Pathways in Synovial Fibroblasts36	9.5	TGFB1, CTGF, BMP7, BMP5
8	Selected targets of HNF110	9.5	LPA, INS, ACE2
9	Chagas disease (American trypanosomiasis)20	9.3	SERPINE1, CCL2, ACE, TGFB1
10	Extrinsic Prothrombin Activation Pathway36	9.3	F2, F3, SERPINC1
11	eIF2 Pathway36	9.3	TGFB1, CTGF, INS, BMP7, BMP5
12	TGF-Beta Pathway36	9.1	TGFB1, CTGF, CCL2, BMP7, BMP5
13	Renin-Angiotensin Pathway36	9.0	TGFB1, AGTR1, ACE, CTGF, CCL2, BMP7
14	Blood Coagulation Signaling Pathways37	9.0	F2, F3, SERPINE1, SERPINC1
15	Complement and coagulation cascades20	8.9	F2, F3, SERPINE1, SERPINC1
16	mTOR Pathway36	8.9	TGFB1, HIF1A, CTGF, INS, BMP7, BMP5
17	SOCS Pathway36	8.9	BMP5, BMP7, INS, CCL2
18	PAK Pathway36	8.7	TGFB1, CTGF, CCL2, BMP7, BMP5
19	p70S6K Signaling36	8.6	TGFB1, CTGF, F2, INS, BMP7, BMP5
20	JAK-STAT Pathway36	8.2	TGFB1, AGTR1, CTGF, F2, CCL2, UBD

Compounds related to nephrosclerosis according to GeneDecks:

(show top 50)    (show all 233)

id	Compound	Score	Top Affiliating Genes
1	sp 60012532 42	11.6	CTGF
2	glucose32	10.4	CTGF, BMP7
3	hirudin32	10.0	ADAMTSL1, SERPINC1, THBS1
4	tranexamic acid32 9 9	11.9	LPA, SERPINE1, SERPINC1
5	benazepril32 9 9	11.8	MTHFR, TGFB1, AGTR1, ACE
6	pge232	9.7	ADM, HIF1A, BMP7
7	captopril32 42 9 9	12.5	ACE, F3, CALCA, ACE2, CTGF, NR3C2
8	thiazide32	9.4	AGTR1, INS, ACE, CALCA, NR3C2
9	ramipril32 9 9	11.3	ACE, TGFB1, SERPINE1, INS, AGTR1, ACE2
10	ang ii32	9.3	NR3C2, ACE, AGTR1, ADM, CTGF, CCL2
11	fucoidan32	9.2	ADAMTSL1, SERPINC1, SERPINE1, F3, THBS1
12	losartan32 34 9 9	11.9	SERPINE1, CCL2, ACE, AGTR1, TGFB1, ADM
13	candesartan32 9 9	10.9	ACE, TGFB1, AGTR1, SERPINE1, HIF1A, CCL2
14	pravastatin32 34 9 18 9	12.8	LCAT, SERPINE1, LPA, CTGF, AGTR1, CCL2
15	protamine32	8.7	ADAMTSL1, F2, F3, SERPINC1, SERPINE1
16	desmopressin32 42 9 9	11.6	ADAMTS13, F2, SERPINC1, F3, SERPINE1
17	testosterone32 9 18 9	11.5	SERPINC1, MTHFR, ALAD, HIF1A, CALCA, THBS1
18	uric acid32 18	9.5	MTHFR, AGTR1, ALAD, INS, SERPINE1, LPA
19	8-isoprostane32	8.5	SERPINE1, AGTR1, CCL2, MPO, INS
20	warfarin32 34 9 18 9	12.5	ACE, MTHFR, LPA, SERPINC1, F2, F3
21	tgf beta132	8.5	THBS1, CCL2, BMP7, SERPINE1, AGTR1, TGFB1
22	rosiglitazone32 9 18 9	11.4	TGFB1, SERPINE1, LPA, INS, CCL2, AGTR1
23	epinephrine32 9 18 9	11.4	F3, ADRB1, INS, F2, AGTR1, ADAMTSL1
24	oxygen32 18	9.3	ACE2, THBS1, ADAMTSL1, NR3C2, AGTR1, MPO
25	epsilon aminocaproic acid32	8.2	THBS1, SERPINC1, SERPINE1, LPA, F3, F2
26	kininogen32	8.1	SERPINE1, F2, ACE, THBS1, F3, SERPINC1
27	actinomycin d32	8.0	LPA, SERPINE1, CCL2, F3, ADM, TGFB1
28	sb 20358032 42	9.0	F3, CTGF, THBS1, SERPINE1, CCL2, HIF1A
29	prostacyclin32	8.0	ADAMTSL1, SERPINC1, CCL2, SERPINE1, F3, AGTR1
30	tacrolimus32 34 9 9	11.0	TGFB1, AGTR1, HIF1A, SERPINE1, INS, F3
31	heparin32 9 18 9	10.9	LCAT, MPO, F3, F2, AGTR1, ADAMTS13
32	vitamin d32	7.9	TGFB1, THBS1, AGTR1, NR3C2, ALAD, CCL2
33	superoxide32 18	8.9	HIF1A, AGTR1, ADM, ACE2, NR3C2, ALAD
34	simvastatin32 34 42 9 18 9	12.8	SERPINE1, AGTR1, CTGF, F2, F3, CCL2
35	homocysteine32 18	8.6	SERPINE1, ADM, F2, F3, MTHFR, CCL2
36	aspirin32 34 18	9.6	AGTR1, TGFB1, ADAMTSL1, F3, ACE, SERPINC1
37	fibrinogen32	7.4	CTGF, INS, ADAMTSL1, AGTR1, THBS1, ADAMTS13
38	cycloheximide32	7.4	HIF1A, ADM, BMP7, CCL2, NR3C2, F3
39	lactate32	7.3	F2, TGFB1, ADM, CTGF, ALAD, CALCA
40	creatinine32	7.2	ACE, NR3C2, CTGF, ALAD, CCL2, MPO
41	retinoic acid32 42 18	9.1	CTGF, NR3C2, HIF1A, THBS1, TGFB1, ADRB1
42	cyclosporin a32 42	8.1	ADM, CTGF, ADAMTS13, TGFB1, NR3C2, HIF1A
43	cholesterol32 9 18 9	10.0	ADAMTSL1, THBS1, AGTR1, ACE2, LPA, ACE
44	lipid32	6.9	ADAMTSL1, THBS1, AGTR1, ACE, CTGF, ALAD
45	nitric oxide32 9 18 9	9.8	LPA, ADRB1, ALAD, THBS1, AGTR1, ADM
46	alanine32	6.6	THBS1, AGTR1, HIF1A, NR3C2, ADM, F2
47	dexamethasone32 42 34 9 9	10.5	BMP7, SERPINC1, LCAT, TGFB1, CCL2, SERPINE1
48	vegf32	6.3	HIF1A, AGTR1, CTGF, CALCA, F3, BMP7
49	estrogen32	5.4	ADM, ADAMTSL1, TGFB1, THBS1, MTHFR, LCAT
50	serine32	4.5	MPO, SERPINC1, SERPINE1, BMP7, LCAT, THBS1

Cellular components related to nephrosclerosis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.7	SERPINE1, THBS1, TGFB1
2	extracellular region	GO:005576	5.7	ADM, TGFB1, THBS1, ACE2, CTGF, CALCA
3	extracellular space	GO:005615	4.7	SERPINC1, ADM, ADAMTS13, TGFB1, THBS1, ACE2

Biological processes related to nephrosclerosis according to GeneDecks:

(show all 34)

id	Name	GO ID	Score	Top Affiliating Genes
1	mononuclear cell proliferation	GO:032943	10.5	TGFB1, ACE
2	regulation of systemic arterial blood pressure by renin-angiotensin	GO:003081	10.4	ACE, ACE2, AGTR1
3	regulation of vasodilation	GO:042312	10.4	ACE, ACE2, AGTR1
4	angiotensin catabolic process in blood	GO:002005	10.4	ACE2, ACE
5	regulation of vasoconstriction	GO:019229	10.4	ACE, ACE2, AGTR1
6	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	10.2	TGFB1, BMP7, BMP5
7	peptide catabolic process	GO:043171	10.1	ACE, ADAMTS13
8	negative regulation of smooth muscle contraction	GO:045986	10.1	ADRB1, CALCA
9	connective tissue replacement involved in inflammatory response wound healing	GO:002248	10.0	TGFB1, HIF1A
10	positive regulation of cellular protein metabolic process	GO:032270	10.0	INS, AGTR1, TGFB1
11	positive regulation of cAMP biosynthetic process	GO:030819	10.0	ADRB1, ADM, CALCA
12	blood circulation	GO:008015	10.0	ADM, LPA
13	negative regulation of plasminogen activation	GO:010757	10.0	SERPINE1, THBS1
14	regulation of inflammatory response	GO:050727	9.9	CALCA, ACE2, AGTR1
15	epithelial to mesenchymal transition	GO:001837	9.8	BMP7, HIF1A, TGFB1
16	positive regulation of fibroblast migration	GO:010763	9.8	THBS1, TGFB1
17	response to progesterone stimulus	GO:032570	9.8	CCL2, THBS1, TGFB1
18	positive regulation of vasodilation	GO:045909	9.8	ADM, CALCA, INS
19	response to glucose stimulus	GO:009749	9.7	CTGF, HIF1A, THBS1, TGFB1
20	positive regulation of collagen biosynthetic process	GO:032967	9.6	F2, CTGF, TGFB1
21	positive regulation of protein kinase B signaling cascade	GO:051897	9.6	TGFB1, THBS1, F3, INS
22	organ regeneration	GO:031100	9.6	CCL2, TGFB1, ADM
23	response to wounding	GO:009611	9.5	ADM, TGFB1, CTGF, F2
24	positive regulation of reactive oxygen species metabolic process	GO:2000379	9.5	THBS1, AGTR1, ACE2, F2
25	response to glucocorticoid stimulus	GO:051384	9.4	ADM, CCL2, LCAT, SERPINE1
26	positive regulation of cell migration	GO:030335	9.4	TGFB1, THBS1, F3, INS
27	negative regulation of fibrinolysis	GO:051918	9.4	THBS1, F2, SERPINE1
28	positive regulation of blood coagulation	GO:030194	9.4	THBS1, F2, SERPINE1
29	positive regulation of angiogenesis	GO:045766	9.3	ADM, THBS1, HIF1A, F3, SERPINE1
30	response to hypoxia	GO:001666	9.1	ADM, TGFB1, THBS1, HIF1A, CCL2
31	aging	GO:007568	9.0	CCL2, F3, CALCA, TGFB1, ADM, ADRB1
32	platelet activation	GO:030168	9.0	SERPINE1, F2, THBS1, TGFB1, ADAMTS13
33	proteolysis	GO:006508	8.8	ADAMTS13, ACE2, ACE, F2, UBD, LPA
34	blood coagulation	GO:007596	8.4	TGFB1, THBS1, F2, F3, SERPINE1, SERPINC1

Molecular functions related to nephrosclerosis according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	bradykinin receptor binding	GO:031711	10.1	ACE, AGTR1
2	peptidyl-dipeptidase activity	GO:008241	9.8	ACE, ACE2
3	fibronectin binding	GO:001968	9.7	THBS1, CTGF, LPA
4	metallopeptidase activity	GO:008237	9.7	ACE, ACE2, ADAMTS13, ADAMTSL1
5	protease binding	GO:002020	9.1	F3, INS, SERPINE1, SERPINC1
6	growth factor activity	GO:008083	8.9	TGFB1, CTGF, F2, BMP7, BMP5
7	heparin binding	GO:008201	8.7	SERPINC1, THBS1, CTGF, CCL2, MPO, LPA
8	receptor binding	GO:005102	8.1	CALCA, F2, CCL2, SERPINE1, ADM
9	protein binding	GO:005515	5.2	HIF1A, AGTR1, THBS1, TGFB1, SYNPO, ADAMTS13