MCID: NPH010
MIFTS: 56

Nephrosclerosis malady

Nephrological diseases category

Summaries for Nephrosclerosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypertensive nephropathy (or \"hypertensive nephrosclerosis\", or \"Hypertensive renal disease\") is a... more...

MalaCards: Nephrosclerosis, also known as renal sclerosis, unspecified, is related to hypertension and renal hypertension. An important gene associated with Nephrosclerosis is ADM (adrenomedullin), and among its related pathways are Renin-angiotensin system and Calcitonin-like ligand receptors. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include kidney, pituitary and heart, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Aliases & Classifications for Nephrosclerosis

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

nephrosclerosis 8 42 44 60
renal sclerosis, unspecified 8
renal sclerosis unspecified 8
renal sclerosis nos 8
renal sclerosis 8


External Ids:

Disease Ontology8 DOID:11664
ICD9CM27 587
MeSH34 D009400

Related Diseases for Nephrosclerosis

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17GeneCards, 18GeneDecks
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Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.3TGFB1, ADM, ADRB1, ACE2, ACE, AGTR1
2renal hypertension30.9ADM, ACE
3malignant hypertension30.6ADM, ADAMTS13, ACE
4glomerulonephritis30.4TGFB1, AGTR1, SYNPO, MPO, LPA, CTGF
5proteinuria30.4TGFB1, ADM, ADAMTS13, ACE2, ACE, AGTR1
6hemolytic-uremic syndrome30.3ADAMTS13
7arteriosclerosis30.2ADM
8uremia30.1ALAD, LPA, LCAT
9ischemia30.1CTGF, BMP7, MPO, ADM, ADAMTS13, NR3C2
10essential hypertension30.1LCAT, LPA, NR3C2, AGTR1, ACE, ACE2
11hypertensive heart disease30.0NR3C2, AGTR1, ACE
12atherosclerosis30.0LCAT, CTGF, LPA, MPO, NR3C2, AGTR1
13acute pancreatitis29.8MPO
14pancreatitis29.8TGFB1, MPO
15renal vascular disease29.8ACE
16renovascular hypertension29.8ADM, ACE, AGTR1
17hyperaldosteronism29.8NR3C2, AGTR1, ACE
18leukemia29.8MPO, NR3C2, TGFB1
19iga glomerulonephritis29.8AGTR1, ACE, ADM, TGFB1
20diabetic retinopathy29.8CTGF, AGTR1, THBS1, ACE, ADM
21obesity29.8LCAT, LPA, NR3C2, THBS1, ADRB1
22vascular disease29.8LCAT, CTGF, LPA, NR3C2, AGTR1, ACE
23chronic kidney failure29.8TGFB1, ADM, ADAMTS13, ALAD, ACE, AGTR1
24diabetes mellitus29.8TGFB1, SERPINC1, ACE, AGTR1, NR3C2, LPA
25kidney disease10.2
26pyelonephritis10.2
27cerebritis10.1
28focal glomerulosclerosis10.0
29chronic pyelonephritis10.0
30tuberculosis10.0
31lung cancer10.0TGFB1
32cor pulmonale10.0AGTR1
33pulmonary disease, chronic obstructive10.0TGFB1
34multiple sclerosis10.0TGFB1
35anuria10.0ACE
36chagas disease10.0ADRB1
37primary pulmonary hypertension10.0ADM
38polycystic ovary syndrome10.0NR3C2
39vesicoureteral reflux10.0AGTR1
40severe acute respiratory syndrome10.0ACE2
41cholestasis10.0LCAT
42hypothyroidism10.0LPA
43oligohydramnios10.0ACE
44myocarditis10.0ADRB1
45intracranial aneurysm10.0ACE2
46myelofibrosis10.0TGFB1
47urticaria10.0ACE
48lupus erythematosus10.0SERPINC1
49cystic fibrosis10.0MPO
50acromegaly10.0LPA

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to nephrosclerosis

Clinical Features for Nephrosclerosis

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Drugs & Therapeutics for Nephrosclerosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Nephrosclerosis

Drug clinical trials:

Search ClinicalTrials for Nephrosclerosis

Search NIH Clinical Center for Nephrosclerosis

Search CenterWatch for Nephrosclerosis

Genetic Tests for Nephrosclerosis

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Anatomical Context for Nephrosclerosis

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32MalaCards
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MalaCards organs/tissues related to Nephrosclerosis:

32
Kidney, Pituitary, Heart, Bone, Smooth muscle, Pancreas, Spleen, Testes, Endothelial

Animal Models for Nephrosclerosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nephrosclerosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.7TGFB1, BMP5, BMP7
2MP:00053699.6THBS1, ACE2, ADRB1, TGFB1
3MP:00053889.6CTGF, BMP7, THBS1, ACE2, TGFB1
4MP:00053709.3LCAT, BMP5, THBS1, ACE, SERPINC1, ADM
5MP:00053679.2ADM, BMP7, BMP5, SYNPO, NR3C2, AGTR1
6MP:00053809.2CTGF, BMP7, BMP5, SERPINC1, ADM, TGFB1
7MP:00053878.7UBD, BMP7, BMP5, MPO, AGTR1, THBS1
8MP:00053768.1AGTR1, NR3C2, MPO, CTGF, CALCA, LCAT
9MP:00053858.0MPO, BMP5, BMP7, CTGF, CALCA, LCAT
10MP:00107688.0NR3C2, MPO, BMP5, BMP7, CTGF, CALCA

Publications for Nephrosclerosis

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50PubMed
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Articles related to Nephrosclerosis:

(show top 50)    (show all 254)
idTitleAuthorsYear
1
Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis. (23151750)
2013
2
The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. (21319131)
2011
3
Expression of ACE and ACE2 in patients with hypertensive nephrosclerosis. (21346373)
2011
4
Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis. (20484896)
2010
5
Molecular factors of angiogenesis in renal tissue of patients with chronic glomerulonephritis: association with nephrosclerosis and anemia]. (19799194)
2009
6
Hypertensive nephrosclerosis. (18408477)
2008
7
Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats. (18698220)
2008
8
Functional polymorphism of the myeloperoxidase gene in hypertensive nephrosclerosis dialysis patients. (18344624)
2007
9
Hypertensive nephrosclerosis. (16988752)
2006
10
Proteinuria and hypertensive nephrosclerosis in African Americans. (15485398)
2004
11
Factors regulating the progression of hypertensive nephrosclerosis. (12854325)
2003
12
Clinical prognostic factors in biopsy-proven benign nephrosclerosis. (12584273)
2003
13
Hypertensive nephrosclerosis in African Americans versus Caucasians. (12081576)
2002
14
A 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor reduces hypertensive nephrosclerosis in stroke-prone spontaneously hypertensive rats. (12473872)
2002
15
Proteinuria in patients with arterial/arteriolar nephrosclerosis. (12400840)
2002
16
Effect of ramipril versus amlodipine on renal outcomes in hypertensive nephrosclerosis. (12003698)
2002
17
Cytochrome c mediates apoptosis in hypertensive nephrosclerosis in Dahl/Rapp rats. (11168948)
2001
18
Hypertensive nephrosclerosis as a relevant cause of chronic renal failure. (11509471)
2001
19
Temporary treatment of prepubescent rats with angiotensin inhibitors suppresses the development of hypertensive nephrosclerosis. (11274226)
2001
20
Calcium antagonist inhibits glomerular cell apoptosis and injuries of L-NAME exacerbated nephrosclerosis in SHR. (11131282)
2000
21
Hypertensive nephrosclerosis pathogenesis, diagnosis and management. (18212435)
1999
22
Hypertensive nephrosclerosis: pathogenesis and prevalence. Essential hypertension is an important cause of end-stage renal disease. (10528641)
1999
23
Effects of angiotensin inhibitors on renal injury and angiotensin receptor expression in early hypertensive nephrosclerosis. (10580398)
1999
24
Quantitative ultrastructural study of afferent and efferent arterioles in IgA glomerulonephritis and benign nephrosclerosis. (8972763)
1996
25
Possible relationship between hyperinsulinemia and glomerular hypertrophy in nephrosclerosis. (8723365)
1996
26
Renovasculopathies of nephrosclerosis in relation to atherosclerosis at ages 25 to 54 years. (8821845)
1996
27
"Strict" blood pressure control and progression of renal disease in hypertensive nephrosclerosis. (7474675)
1995
28
Clinical features of benign hypertensive nephrosclerosis at time of renal biopsy. (8327642)
1993
29
Long-term improvement in renal function after short-term strict blood pressure control in hypertensive nephrosclerosis. (2544523)
1989
30
Quantitation of hypertensive nephrosclerosis on an objective rational scale of measure in adults and children. (3751980)
1986
31
Effect of castration on the experimental renal hypertension of the rat. Blood pressure, nephrosclerosis, long-chain fatty acids, and N-acetylation of PAH in the kidney. (4000342)
1985
32
Renal vascular lesions in severe hypertension. Transitional changes from benign to malignant nephrosclerosis. (6869004)
1983
33
Dexamethasone suppressible hyperaldosteronism in a child with nephrosclerosis. (6277130)
1982
34
Gross hematuria in a patient on chronic renal dialysis for the treatment of end stage renal disease secondary to nephrosclerosis. (7277607)
1981
35
Asymptomatic mild hyperuricaemia: an indicator of nephrosclerosis in essential hypertension. (7449292)
1980
36
Endotheliotropic (hemolytic) nephroangiopathy and its various manifestation forms (thrombotic microangiopathy, primary malignant nephrosclerosis, hemolytic-uremic syndrome). (7382329)
1980
37
Pathology of malignant nephrosclerosis with special reference to the difference between histologic manifestations of pure and exacerbated forms. (694919)
1978
38
Late follow-up in women with nephrosclerosis diagnosed at pregnancy. (717448)
1978
39
Nephrosclerosis postpartum and in women taking oral contraceptives. (1247349)
1976
40
The third Volhard lecture. Tension and the artery: the experimental elucidation of pseudo-uraemia and malignant nephrosclerosis. (799554)
1976
41
Primary malignant nephrosclerosis. (1071614)
1976
42
Bilateral nephrectomy for renal failure and hypertension due to malignant nephrosclerosis. (4619666)
1974
43
Bilateral nephrectomy and renal homotransplantation for malignant nephrosclerosis. (4576897)
1973
44
The role of nephrosclerosis in separate function tests. (5444314)
1970
45
Late effects of total-body Roentgen irradiation. IV. Hypertension and nephrosclerosis in femal Wistar rats surviving 1000 r hypoxic total-body irradiation. (13570814)
1958
46
Late effects of total-body roentgen irradiation. II. The influence of fractionated and single radiation doses on the incidence of tumors, nephrosclerosis, and adrenal vacuolation in Wistar rats during various periods of postirradiation survival. (13468880)
1957
47
On the pathogenesis of red essential arterial hypertension and of malignant nephrosclerosis. (18857649)
1948
48
Hormonal hypertension and nephrosclerosis as influenced by the diet. (18107727)
1948
49
Influence of the diet upon the nephrosclerosis, periarteritis nodosa and cardiac lesions produced by the endocrine kidney. (18871458)
1948
50
Nephrosclerosis, benign and malignant. (20293863)
1947

Genetic Variations for Nephrosclerosis

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Expression for genes affiliated with Nephrosclerosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephrosclerosis

Search GEO for disease gene expression data for Nephrosclerosis.

Pathways for genes affiliated with Nephrosclerosis

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Sources:
29KEGG, 53Reactome, 55SinoBiological, 49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Nephrosclerosis

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Nephrosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1pge24410.7TGFB1
2estrogen4410.5LPA, LCAT
3benazepril44 1111.4AGTR1, TGFB1, ACE
4procollagen4410.4TGFB1
5angiotensin ii28 2411.3ACE2, ACE, AGTR1
6carvedilol44 49 28 1113.3ADRB1, ADM, ACE, AGTR1
7aldosterone28 11 2412.3ADM, AGTR1, CTGF, NR3C2
8clonidine44 28 1112.3CALCA, ADRB1, AGTR1
9eplerenone44 59 28 1113.3NR3C2, AGTR1, ACE, ACE2
10thiazide4410.2CALCA, ACE, AGTR1, NR3C2
11ramipril44 1111.2TGFB1, ACE, AGTR1, ACE2
12superoxide44 2411.2LPA, NR3C2, ALAD, AGTR1
13nitroglycerin44 1111.2AGTR1, ACE, CALCA, ADM
14lisinopril44 11 2412.2AGTR1, ACE2, ACE
15norepinephrine44 11 2412.2CALCA, NR3C2, ADRB1, ADM
16amiloride44 28 1112.1TGFB1, NR3C2, MPO, CTGF
17methacholine44 1111.1TGFB1, AGTR1, MPO, CALCA
18ang ii4410.1ADM, CTGF, AGTR1, ACE, TGFB1, NR3C2
19losartan44 49 28 1113.0NR3C2, CTGF, AGTR1, ADM, TGFB1, ACE
20vitamin d4410.0AGTR1, NR3C2, CALCA, THBS1, ALAD
21malondialdehyde4410.0ALAD, ADM, LPA, MPO
22thiorphan44 28 1112.0ADM, ACE, CALCA
23captopril44 28 49 59 1114.0ADM, ACE2, CTGF, NR3C2, CALCA
24tgf beta14410.0TGFB1, THBS1, CTGF, BMP7, AGTR1
25kininogen4410.0SERPINC1, ACE, THBS1, MPO
26potassium44 11 2411.9ALAD, ACE, AGTR1, NR3C2, ADM, ADRB1
27dexamethasone44 49 28 1112.9BMP7, TGFB1, LCAT, NR3C2, ADRB1, CTGF
28propranolol44 28 49 11 2413.9CALCA, MPO, ADRB1, ADM
29prostacyclin449.9ACE, ADM, SERPINC1, CTGF, AGTR1, THBS1
30acth449.9ADM, LPA, NR3C2, AGTR1, CALCA
31cyclosporin a44 28 5911.8CALCA, ADM, ADAMTS13, CTGF, THBS1, NR3C2
32oxygen44 2410.8BMP7, MPO, NR3C2, ACE2, ADRB1, ADM
33atenolol44 28 49 11 2413.8AGTR1, ACE, ADRB1
34heparin44 28 11 2412.8LCAT, CTGF, BMP7, MPO, ADAMTS13, LPA
35aspirin44 49 28 2412.7AGTR1, TGFB1, SERPINC1, ACE, LPA
36fibrinogen449.7LPA, AGTR1, THBS1, CTGF, ADAMTS13, SERPINC1
37pravastatin44 49 28 11 2413.7CTGF, LCAT, AGTR1, LPA
38chloride449.7NR3C2, LPA, MPO, ADAMTS13, ACE2
39creatinine449.6ADAMTS13, ACE, BMP7, LPA, SYNPO, TGFB1
40alanine449.6NR3C2, AGTR1, ADM, LCAT, TGFB1, ADRB1
41cholesterol44 28 11 2412.5ADM, ACE2, AGTR1, NR3C2, THBS1, LPA
42testosterone44 59 11 2412.5CALCA, NR3C2, THBS1, ADM, ALAD, LCAT
43glucose449.4CTGF, ADRB1, ACE, AGTR1, NR3C2, LPA
44lactate449.4ALAD, TGFB1, ADM, CALCA, MPO, CTGF
45retinoic acid44 2410.4BMP7, MPO, NR3C2, ADRB1, THBS1, TGFB1
46lipid449.2LCAT, BMP7, LPA, THBS1, CTGF, ACE
47serine449.2LCAT, CTGF, BMP7, THBS1, NR3C2, TGFB1
48vegf449.0LPA, BMP7, CTGF, CALCA, AGTR1, THBS1
49nitric oxide44 11 2410.8ALAD, NR3C2, AGTR1, THBS1, ACE, MPO
50calcium44 49 11 2411.8CALCA, MPO, ADRB1, ADAMTS13, ALAD, ACE

GO Terms for genes affiliated with Nephrosclerosis

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16Gene Ontology
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Cellular components related to Nephrosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4CALCA, CTGF, BMP7, LPA, THBS1, ACE
2extracellular spaceGO:0056157.7TGFB1, LCAT, CALCA, CTGF, BMP7, BMP5

Biological processes related to Nephrosclerosis according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:03294310.5TGFB1, ACE
2peptide catabolic processGO:04317110.5ADAMTS13, ACE
3angiotensin catabolic process in bloodGO:00200510.4ACE2, ACE
4positive regulation of fibroblast migrationGO:01076310.4TGFB1, THBS1
5negative regulation of smooth muscle contractionGO:04598610.4ADRB1, CALCA
6positive regulation of chemotaxisGO:05092110.3THBS1, TGFB1
7regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.3ACE2, ACE, AGTR1
8regulation of vasodilationGO:04231210.3ACE2, ACE, AGTR1
9positive regulation of dendrite developmentGO:190000610.3BMP7, BMP5
10regulation of vasoconstrictionGO:01922910.3AGTR1, ACE, ACE2
11positive regulation of pathway-restricted SMAD protein phosphorylationGO:01086210.3TGFB1, BMP5, BMP7
12positive regulation of cellular protein metabolic processGO:03227010.3AGTR1, TGFB1
13response to woundingGO:00961110.3CTGF, ADM, TGFB1
14positive regulation of cAMP biosynthetic processGO:03081910.3ADM, ADRB1, CALCA
15G-protein coupled receptor internalizationGO:00203110.3ADM, CALCA
16low-density lipoprotein particle remodelingGO:03437410.3AGTR1, MPO
17positive regulation of reactive oxygen species metabolic processGO:200037910.3AGTR1, THBS1, ACE2
18response to glucose stimulusGO:00974910.2TGFB1, THBS1, CTGF
19agingGO:00756810.2TGFB1, ADM, ADRB1, CALCA
20regulation of inflammatory responseGO:05072710.2CALCA, AGTR1, ACE2
21angiotensin maturationGO:00200310.2ACE, ACE2
22ossificationGO:00150310.1BMP5, BMP7, CTGF
23negative regulation of blood vessel endothelial cell migrationGO:04353710.1THBS1, TGFB1
24elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.1AGTR1, CALCA
25positive regulation of peptidyl-threonine phosphorylationGO:01080010.1BMP7, TGFB1
26proteolysisGO:0065089.8UBD, LPA, ACE, ACE2, ADAMTS13
27elevation of cytosolic calcium ion concentrationGO:0072049.7ADM, AGTR1, CALCA

Molecular functions related to Nephrosclerosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:03171110.3ACE, AGTR1
2peptidyl-dipeptidase activityGO:00824110.1ACE, ACE2
3fibronectin bindingGO:00196810.0THBS1, LPA, CTGF
4integrin bindingGO:0051789.9ADAMTS13, THBS1, CTGF
5growth factor activityGO:0080839.7TGFB1, BMP5, BMP7, CTGF
6metallopeptidase activityGO:0082379.6ACE, ACE2, ADAMTS13
7heparin bindingGO:0082019.6SERPINC1, THBS1, MPO, LPA, CTGF
8protein bindingGO:0055158.1SYNPO, BMP7, CTGF, UBD, CALCA, LCAT

Products for genes affiliated with Nephrosclerosis

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Sources for Nephrosclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet