MCID: NPH010
MIFTS: 53

Nephrosclerosis malady

Rare diseases, Cardiovascular diseases, Nephrological diseases categories
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Summaries for Nephrosclerosis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Hypertensive nephropathy (or \"hypertensive nephrosclerosis\", or \"Hypertensive renal disease\") is a... more...

MalaCards: Nephrosclerosis, also known as renal sclerosis, unspecified, is related to hypertension and glomerulonephritis. An important gene associated with Nephrosclerosis is ADM (adrenomedullin), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Mitotic Roles of Polo Like Kinases. The compounds temocaprilat and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include kidney, pituitary and heart, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Aliases & Classifications for Nephrosclerosis

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8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Nephrological diseases


Aliases & Descriptions:

nephrosclerosis 8 43 45 62
renal sclerosis, unspecified 8
renal sclerosis unspecified 8
renal sclerosis nos 8
renal sclerosis 8


External Ids:

Disease Ontology8 DOID:11664
ICD9CM27 587
MeSH35 D009400

Related Diseases for Nephrosclerosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 89)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.2ACE, ADM, TGFB1, AGTR1, NR3C2
2glomerulonephritis30.5TGFB1, AGTR1
3malignant hypertension30.4ACE, ADM
4proteinuria30.3TGFB1, ADM, ACE, AGTR1, NR3C2
5glomerulosclerosis30.1AGTR1, ACE, ADM, TGFB1
6essential hypertension30.0ACE, ADM, NR3C2, AGTR1
7renal hypertension30.0ACE, ADM
8atherosclerosis30.0TGFB1, NR3C2, AGTR1, ACE
9renovascular hypertension29.9ADM, AGTR1, ACE
10diabetic retinopathy29.9AGTR1, ACE, ADM
11hypertensive heart disease29.9AGTR1, NR3C2, ACE
12hyperaldosteronism29.9ACE, AGTR1, NR3C2
13insulin resistance29.8NR3C2, AGTR1, ACE
14iga glomerulonephritis29.8TGFB1, ADM, ACE, AGTR1
15diabetes mellitus29.7NR3C2, AGTR1, TGFB1, ACE
16hemolytic-uremic syndrome10.3
17kidney disease10.3
18periarteritis nodosa10.2
19cerebritis10.2
20arteriosclerosis10.2
21ischemia10.2
22pyelonephritis10.2
23uremia10.2
24anuria10.1ACE
25urinary tract obstruction10.1ACE
26oligohydramnios10.1ACE
27chronic pyelonephritis10.1
28renal tubular dysgenesis10.0AGTR1, ACE
29adrenocortical carcinoma10.0AGTR1, ADM
30adrenal adenoma10.0AGTR1, ADM
31erythrocytosis10.0AGTR1, ACE
32focal segmental glomerulosclerosis10.0AGTR1, ACE
33stroke, ischemic10.0ACE, ADM
34familial hyperlipidemia10.0AGTR1, ACE
35hypokalemia10.0ACE, NR3C2
36hypercholesterolemia10.0ACE, AGTR1
37sudden cardiac death multi-gene panels10.0NR3C2, ACE
38ureteral obstruction10.0TGFB1, AGTR1
39proliferative vitreoretinopathy10.0ADM, TGFB1
40coronary artery disease10.0ACE, ADM, AGTR1
41conn's syndrome10.0AGTR1, ADM, NR3C2
42type 2 diabetes mellitus10.0AGTR1, ACE, ADM
43noonan syndrome10.0ACE, AGTR1
44idiopathic edema10.0ADM, ACE, NR3C2
45pulmonary fibrosis10.0AGTR1, TGFB1
46pre-eclampsia10.0ADM, NR3C2, AGTR1
47congenital heart disease10.0AGTR1, NR3C2, ACE
48vascular disease10.0ACE, AGTR1, NR3C2
49systemic scleroderma10.0ACE, TGFB1
50hyperglycemia10.0ACE, AGTR1, TGFB1

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to nephrosclerosis

Symptoms for Nephrosclerosis

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Drugs & Therapeutics for Nephrosclerosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Nephrosclerosis

Search NIH Clinical Center for Nephrosclerosis

Genetic Tests for Nephrosclerosis

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Anatomical Context for Nephrosclerosis

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33MalaCards
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MalaCards organs/tissues related to Nephrosclerosis:

33
Kidney, Pituitary, Heart, Bone, Smooth muscle, Pancreas, Spleen, Testes, Endothelial

Animal Models for Nephrosclerosis or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Nephrosclerosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.8AGTR1, NR3C2, ACE, ADM, TGFB1
2MP:00053857.8TGFB1, ADM, ACE, NR3C2, AGTR1
3MP:00053877.7TGFB1, ADM, ACE, UBD, AGTR1
4MP:00053977.6UBD, NR3C2, ACE, ADM, TGFB1
5MP:00107687.6AGTR1, NR3C2, ACE, ADM, TGFB1
6MP:00053847.5UBD, NR3C2, ACE, ADM, TGFB1
7MP:00053767.3TGFB1, ADM, ACE, NR3C2, AGTR1

Publications for Nephrosclerosis

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Sources:
52PubMed
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Articles related to Nephrosclerosis:

(show top 50)    (show all 253)
idTitleAuthorsYear
1
Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis. (23151750)
2013
2
Castleman's disease accompanied by hypolipidemic cerebral hemorrhage and nephrosclerosis. (23857095)
2013
3
Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis. (22236281)
2012
4
The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. (21319131)
2011
5
Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. (21080950)
2010
6
The association between age and nephrosclerosis on renal biopsy among healthy adults. (20439574)
2010
7
Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. (19745105)
2009
8
Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease in TGF-beta(1). (17998773)
2007
9
Hypertensive nephrosclerosis. (16988752)
2006
10
Dr. Yang Nizhi's experience in treating benign arteriolar nephrosclerosis. (16705856)
2006
11
Hypertensive nephrosclerosis: update. (15202608)
2004
12
Stent angioplasty of severe atherosclerotic ostial renal artery stenosis in patients with diabetes mellitus and nephrosclerosis. (12652503)
2003
13
Hypertensive nephrosclerosis in African Americans versus Caucasians. (12081576)
2002
14
Nipradilol prevents L-NAME-exacerbated nephrosclerosis with decreasing of caspase-3 expression in SHR. (12135323)
2002
15
A 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor reduces hypertensive nephrosclerosis in stroke-prone spontaneously hypertensive rats. (12473872)
2002
16
Cytochrome c mediates apoptosis in hypertensive nephrosclerosis in Dahl/Rapp rats. (11168948)
2001
17
Intrauterine food restriction as a determinant of nephrosclerosis. (11228169)
2001
18
Cilnidipine is as effective as benazepril for control of blood pressure and proteinuria in hypertensive patients with benign nephrosclerosis. (11510750)
2001
19
Hypertensive nephrosclerosis pathogenesis, diagnosis and management. (18212435)
1999
20
The clinical diagnosis of hypertensive nephrosclerosis--how reliable is it? (10069175)
1999
21
Accuracy of the diagnosis of hypertensive nephrosclerosis in African Americans: a report from the African American Study of Kidney Disease (AASK) Trial. AASK Pilot Study Investigators. (8995739)
1997
22
Hydrochlorothiazide exacerbates nitric oxide-blockade nephrosclerosis with glomerular hypertension in spontaneously hypertensive rats. (8818920)
1996
23
Immunohistochemical analysis of type III and IV collagens in tubulointerstitial damage in human benign nephrosclerosis. (8746616)
1995
24
Effects of novel, nonpeptide vasopressin antagonists on progressive nephrosclerosis in rats. (7630164)
1995
25
Hypertensive nephrosclerosis in the Dahl/Rapp rat. Initial sites of injury and effect of dietary L-arginine supplementation. (8441251)
1993
26
Clinical features of benign hypertensive nephrosclerosis at time of renal biopsy. (8327642)
1993
27
Cholinergic vasodilatory effect of an imidazoindole on the nephrosclerosis of hypertensive rats. (2383253)
1990
28
Decompensated benign nephrosclerosis and secondary malignant nephrosclerosis. (3720032)
1986
29
Quantitation of hypertensive nephrosclerosis on an objective rational scale of measure in adults and children. (3751980)
1986
30
Proteinuria in benign nephrosclerosis. (3729631)
1986
31
Marked proteinuria in hypertensive nephrosclerosis. (3160240)
1985
32
Glomerular injury in malignant nephrosclerosis. (740104)
1978
33
Pathology of malignant nephrosclerosis with special reference to the difference between histologic manifestations of pure and exacerbated forms. (694919)
1978
34
Nephrosclerosis postpartum and in women taking oral contraceptives. (1247349)
1976
35
Asymmetrical interlobar nephrosclerosis. (4131975)
1974
36
Bilateral nephrectomy and renal homotransplantation for malignant nephrosclerosis. (4576897)
1973
37
The role of nephrosclerosis in separate function tests. (5444314)
1970
38
RHEUMATIC NEPHROSCLEROSIS WITH SPECIAL REFERENCE TO RHEUMATIC ENDARTERITIS. (14297514)
1965
39
IMMUNOCYTOCHEMICAL OBSERVATIONS ON THE VASCULAR NECROSIS AND RENAL GLOMERULAR LESIONS OF MALIGNANT NEPHROSCLEROSIS. (14328020)
1965
40
MALIGNANT HYPERTENSION, MALIGNANT NEPHROSCLEROSIS, AND SYSTEMIC VASCULITIS. (14303079)
1965
41
Radiation nephrosclerosis. (13725173)
1960
42
The hormonal production of nephrosclerosis and periarteritis nodosa in the primate. (13383223)
1957
43
CLINICO-PATHOLOGICAL conference: large fibromyomata uteri with hypertensive heart disease and arteriolar nephrosclerosis. (13086088)
1953
44
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952
45
Malignant nephrosclerosis without retinal edema in a child; long-term observations and renal function studies. (14902103)
1952
46
VA clinical pathological conference: cerebral hemorrhage associated with malignant nephrosclerosis and cardiac hypertrophy. (13013101)
1952
47
Unilateral renal cortical necrosis and unilateral benign and malignant nephrosclerosis, associated with contralateral renal artery occlusion: report of a case. (14789332)
1951
48
Nephrosclerosis]. (20271308)
1947
49
Nephrosclerosis, benign and malignant. (20293863)
1947
50
Benign and Malignant Hypertension and Nephrosclerosis: A Clinical and Pathological Study. (19970253)
1936

Variations for Nephrosclerosis

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Expression for genes affiliated with Nephrosclerosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephrosclerosis

Search GEO for disease gene expression data for Nephrosclerosis.

Pathways for genes affiliated with Nephrosclerosis

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 51PharmGKB
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Pathways related to Nephrosclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.1ACE, TGFB1
29.1TGFB1, UBD
3
Show member pathways
8.7AGTR1, ACE, TGFB1
4
Show member pathways
8.7AGTR1, UBD, TGFB1
5
Show member pathways
8.1AGTR1, NR3C2, ACE, TGFB1

Compounds for genes affiliated with Nephrosclerosis

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45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Nephrosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1temocaprilat459.9ACE, AGTR1
2aliskiren45 1110.9ACE, AGTR1
3lacidipine459.9AGTR1, ACE
4angiotensin ii29 2410.8AGTR1, ACE
5omapatrilat459.8ADM, ACE
6saralasin459.8AGTR1, ACE
7eprosartan45 29 1111.8AGTR1, ACE
8cilazapril45 1110.8AGTR1, ACE
9trandolapril45 1110.8AGTR1, ACE
10pd12331945 2910.7ACE, AGTR1
11bradykinin61 29 2411.7AGTR1, ACE
12olmesartan45 29 1111.7ACE, AGTR1
13triamterene45 24 1111.7ACE, NR3C2
14fosinopril45 1110.6AGTR1, ACE
15doxazosin45 1110.5AGTR1, ACE, ADM
16quinapril45 51 1111.5AGTR1, ACE
17carvedilol45 51 29 1112.5ADM, ACE, AGTR1
18nitroglycerin45 1110.5ADM, AGTR1, ACE
19aldosterone29 24 1111.4NR3C2, AGTR1, ADM
20catecholamine459.3ADM, NR3C2, AGTR1
21eplerenone45 61 29 1112.3NR3C2, ACE, AGTR1
22thiazide459.3AGTR1, ACE, NR3C2
23felodipine45 29 1111.3NR3C2, ACE, AGTR1
24hydrochlorothiazide45 29 51 24 1113.3ACE, NR3C2, AGTR1
25enalapril45 51 1111.3ACE, AGTR1, NR3C2
26spironolactone45 61 29 51 1113.3NR3C2, AGTR1, ACE
27prostacyclin459.2ADM, ACE, AGTR1
28sodium nitroprusside459.1AGTR1, ADM, TGFB1
29benazepril45 51 1111.1TGFB1, ACE, AGTR1
30ramipril45 1110.1ACE, TGFB1, AGTR1
31perindopril45 51 1111.1AGTR1, ACE, TGFB1
32candesartan45 51 29 1112.1TGFB1, ACE, AGTR1
33verapamil45 29 51 24 1113.0AGTR1, TGFB1, ACE
34nifedipine45 29 51 1112.0TGFB1, ACE, AGTR1
35captopril45 61 51 29 1112.9AGTR1, NR3C2, ACE, ADM
36norepinephrine45 24 1110.9ADM, NR3C2, ACE, AGTR1
37potassium45 24 1110.9AGTR1, NR3C2, ACE, ADM
38sodium45 249.8NR3C2, ACE, AGTR1, ADM
39cholesterol45 29 24 1111.8NR3C2, ACE, ADM, AGTR1
40acth458.7AGTR1, ADM, NR3C2
41tacrolimus45 51 1110.6AGTR1, TGFB1, NR3C2
42actinomycin d458.6NR3C2, TGFB1, AGTR1, ADM
43cyclosporin a45 29 6110.5AGTR1, NR3C2, ADM, TGFB1
44cycloheximide458.5NR3C2, AGTR1, ADM, TGFB1
45dexamethasone45 51 29 1111.4ADM, TGFB1, NR3C2, AGTR1
46nitric oxide45 24 1110.4ACE, ADM, AGTR1, NR3C2
47alanine458.2AGTR1, TGFB1, NR3C2, ADM
48ang ii458.1TGFB1, NR3C2, ACE, AGTR1, ADM
49losartan45 51 29 1111.1NR3C2, ACE, ADM, TGFB1, AGTR1
50creatinine458.1TGFB1, AGTR1, ADM, ACE, NR3C2

GO Terms for genes affiliated with Nephrosclerosis

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16Gene Ontology
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Biological processes related to Nephrosclerosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.8AGTR1, ACE
2regulation of vasodilationGO:0423129.7AGTR1, ACE
3regulation of vasoconstrictionGO:0192299.7AGTR1, ACE
4positive regulation of cellular protein metabolic processGO:0322709.4TGFB1, AGTR1
5mononuclear cell proliferationGO:0329439.4ACE, TGFB1
6kidney developmentGO:0018229.4AGTR1, ACE
7organ regenerationGO:0311009.4ADM, TGFB1
8response to woundingGO:0096119.3ADM, TGFB1
9positive regulation of cytosolic calcium ion concentrationGO:0072049.3AGTR1, ADM
10myeloid dendritic cell differentiationGO:0430119.3UBD, TGFB1
11female pregnancyGO:0075659.2TGFB1, ADM
12agingGO:0075689.2ADM, TGFB1
13positive regulation of apoptotic processGO:0430658.9TGFB1, ADM, UBD

Molecular functions related to Nephrosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.2AGTR1, ACE
2protein bindingGO:0055157.1AGTR1, UBD, NR3C2, ACE, ADM, TGFB1

Products for genes affiliated with Nephrosclerosis

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  • Antibodies
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Sources for Nephrosclerosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet