MCID: NPH010
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Nephrosclerosis malady

Rare diseases, Cardiovascular diseases, Nephrological diseases categories
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Summaries for Nephrosclerosis

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Wikipedia:65 Hypertensive nephropathy (or \"hypertensive nephrosclerosis\", or \"Hypertensive renal disease\") is a... more...

MalaCards based summary: Nephrosclerosis, also known as renal sclerosis, is related to malignant hypertension and hypertension. An important gene associated with Nephrosclerosis is ADM (adrenomedullin), and among its related pathways are Hypertrophic cardiomyopathy (HCM) and Mitotic Roles of Polo Like Kinases. The compounds temocaprilat and aliskiren have been mentioned in the context of this disorder. Affiliated tissues include kidney, pituitary and heart, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Aliases & Classifications for Nephrosclerosis

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Nephrosclerosis, Aliases & Descriptions:

Name: Nephrosclerosis 8 42 44 62
 
Renal Sclerosis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Nephrological diseases


External Ids:

Disease Ontology8 DOID:11664
MeSH34 D009400
ICD9CM27 587

Related Diseases for Nephrosclerosis

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Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1malignant hypertension30.7ACE, ADM
2hypertension30.6ACE, ADM, TGFB1, AGTR1, NR3C2
3glomerulonephritis30.4TGFB1, AGTR1
4renal hypertension30.2ACE, ADM
5hypertensive heart disease30.1AGTR1, NR3C2, ACE
6renovascular hypertension30.0ADM, AGTR1, ACE
7diabetic retinopathy30.0AGTR1, ACE, ADM
8hyperaldosteronism29.8ACE, AGTR1, NR3C2
9glomerulosclerosis29.8AGTR1, ACE, ADM, TGFB1
10essential hypertension29.8ACE, ADM, NR3C2, AGTR1
11insulin resistance29.7NR3C2, AGTR1, ACE
12proteinuria29.7TGFB1, ADM, ACE, AGTR1, NR3C2
13atherosclerosis29.5TGFB1, NR3C2, AGTR1, ACE
14diabetes mellitus29.3NR3C2, AGTR1, TGFB1, ACE
15anuria10.4ACE
16urinary tract obstruction10.4ACE
17oligohydramnios10.4ACE
18hemolytic-uremic syndrome10.3
19kidney disease10.3
20pyelonephritis10.2
21periarteritis nodosa10.2
22renal tubular dysgenesis10.2AGTR1, ACE
23adrenocortical carcinoma10.2AGTR1, ADM
24adrenal cortical adenoma10.2AGTR1, ADM
25erythrocytosis10.2AGTR1, ACE
26cerebritis10.2
27arteriosclerosis10.2
28ischemia10.2
29uremia10.2
30focal segmental glomerulosclerosis10.2AGTR1, ACE
31stroke, ischemic10.1ACE, ADM
32familial hyperlipidemia10.1AGTR1, ACE
33sudden cardiac death multi-gene panels10.1ACE, NR3C2
34hypercholesterolemia10.1ACE, AGTR1
35cerebral hemorrhage10.1
36chronic pyelonephritis10.1
37tuberculosis10.1
38hypokalemia10.1ACE, NR3C2
39ureteral obstruction10.1TGFB1, AGTR1
40proliferative vitreoretinopathy10.1ADM, TGFB1
41coronary artery anomaly10.0ACE, ADM, AGTR1
42conn's syndrome10.0AGTR1, ADM, NR3C2
43type 2 diabetes mellitus10.0AGTR1, ACE, ADM
44noonan syndrome10.0ACE, AGTR1
45idiopathic edema10.0ADM, ACE, NR3C2
46pulmonary fibrosis10.0AGTR1, TGFB1
47pre-eclampsia10.0ADM, NR3C2, AGTR1
48nephrosis9.9
49congenital heart disease9.9AGTR1, NR3C2, ACE
50end stage renal failure9.9

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to nephrosclerosis

Symptoms for Nephrosclerosis

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Drugs & Therapeutics for Nephrosclerosis

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Drug clinical trials:

Search ClinicalTrials for Nephrosclerosis

Search NIH Clinical Center for Nephrosclerosis

Genetic Tests for Nephrosclerosis

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Anatomical Context for Nephrosclerosis

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MalaCards organs/tissues related to Nephrosclerosis:

32
Kidney, Pituitary, Heart, Bone, Smooth muscle, Pancreas, Spleen, Testes, Endothelial

Animal Models for Nephrosclerosis or affiliated genes

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MGI Mouse Phenotypes related to Nephrosclerosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.8AGTR1, NR3C2, ACE, ADM, TGFB1
2MP:00053857.8TGFB1, ADM, ACE, NR3C2, AGTR1
3MP:00053877.7TGFB1, ADM, ACE, UBD, AGTR1
4MP:00053977.6UBD, NR3C2, ACE, ADM, TGFB1
5MP:00107687.6AGTR1, NR3C2, ACE, ADM, TGFB1
6MP:00053847.5UBD, NR3C2, ACE, ADM, TGFB1
7MP:00053767.3TGFB1, ADM, ACE, NR3C2, AGTR1

Publications for Nephrosclerosis

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Articles related to Nephrosclerosis:

(show top 50)    (show all 252)
idTitleAuthorsYear
1
Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis. (23151750)
2013
2
Castleman's disease accompanied by hypolipidemic cerebral hemorrhage and nephrosclerosis. (23857095)
2013
3
Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis. (22236281)
2012
4
The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. (21319131)
2011
5
Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. (21080950)
2010
6
The association between age and nephrosclerosis on renal biopsy among healthy adults. (20439574)
2010
7
Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. (19745105)
2009
8
Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease in TGF-beta(1). (17998773)
2007
9
Hypertensive nephrosclerosis. (16988752)
2006
10
Dr. Yang Nizhi's experience in treating benign arteriolar nephrosclerosis. (16705856)
2006
11
Hypertensive nephrosclerosis: update. (15202608)
2004
12
Stent angioplasty of severe atherosclerotic ostial renal artery stenosis in patients with diabetes mellitus and nephrosclerosis. (12652503)
2003
13
Hypertensive nephrosclerosis in African Americans versus Caucasians. (12081576)
2002
14
Nipradilol prevents L-NAME-exacerbated nephrosclerosis with decreasing of caspase-3 expression in SHR. (12135323)
2002
15
A 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor reduces hypertensive nephrosclerosis in stroke-prone spontaneously hypertensive rats. (12473872)
2002
16
Cytochrome c mediates apoptosis in hypertensive nephrosclerosis in Dahl/Rapp rats. (11168948)
2001
17
Intrauterine food restriction as a determinant of nephrosclerosis. (11228169)
2001
18
Cilnidipine is as effective as benazepril for control of blood pressure and proteinuria in hypertensive patients with benign nephrosclerosis. (11510750)
2001
19
Hypertensive nephrosclerosis pathogenesis, diagnosis and management. (18212435)
1999
20
The clinical diagnosis of hypertensive nephrosclerosis--how reliable is it? (10069175)
1999
21
Progression of renal failure and hypertensive nephrosclerosis. (9839285)
1998
22
Accuracy of the diagnosis of hypertensive nephrosclerosis in African Americans: a report from the African American Study of Kidney Disease (AASK) Trial. AASK Pilot Study Investigators. (8995739)
1997
23
Immunohistochemical analysis of type III and IV collagens in tubulointerstitial damage in human benign nephrosclerosis. (8746616)
1995
24
Effects of novel, nonpeptide vasopressin antagonists on progressive nephrosclerosis in rats. (7630164)
1995
25
Hypertensive nephrosclerosis in the Dahl/Rapp rat. Initial sites of injury and effect of dietary L-arginine supplementation. (8441251)
1993
26
Clinical features of benign hypertensive nephrosclerosis at time of renal biopsy. (8327642)
1993
27
Cholinergic vasodilatory effect of an imidazoindole on the nephrosclerosis of hypertensive rats. (2383253)
1990
28
Decompensated benign nephrosclerosis and secondary malignant nephrosclerosis. (3720032)
1986
29
Quantitation of hypertensive nephrosclerosis on an objective rational scale of measure in adults and children. (3751980)
1986
30
Proteinuria in benign nephrosclerosis. (3729631)
1986
31
Marked proteinuria in hypertensive nephrosclerosis. (3160240)
1985
32
Glomerular injury in malignant nephrosclerosis. (740104)
1978
33
Pathology of malignant nephrosclerosis with special reference to the difference between histologic manifestations of pure and exacerbated forms. (694919)
1978
34
Nephrosclerosis postpartum and in women taking oral contraceptives. (1247349)
1976
35
Asymmetrical interlobar nephrosclerosis. (4131975)
1974
36
Bilateral nephrectomy and renal homotransplantation for malignant nephrosclerosis. (4576897)
1973
37
The role of nephrosclerosis in separate function tests. (5444314)
1970
38
RHEUMATIC NEPHROSCLEROSIS WITH SPECIAL REFERENCE TO RHEUMATIC ENDARTERITIS. (14297514)
1965
39
IMMUNOCYTOCHEMICAL OBSERVATIONS ON THE VASCULAR NECROSIS AND RENAL GLOMERULAR LESIONS OF MALIGNANT NEPHROSCLEROSIS. (14328020)
1965
40
MALIGNANT HYPERTENSION, MALIGNANT NEPHROSCLEROSIS, AND SYSTEMIC VASCULITIS. (14303079)
1965
41
Radiation nephrosclerosis. (13725173)
1960
42
The hormonal production of nephrosclerosis and periarteritis nodosa in the primate. (13383223)
1957
43
CLINICO-PATHOLOGICAL conference: large fibromyomata uteri with hypertensive heart disease and arteriolar nephrosclerosis. (13086088)
1953
44
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952
45
Malignant nephrosclerosis without retinal edema in a child; long-term observations and renal function studies. (14902103)
1952
46
VA clinical pathological conference: cerebral hemorrhage associated with malignant nephrosclerosis and cardiac hypertrophy. (13013101)
1952
47
Unilateral renal cortical necrosis and unilateral benign and malignant nephrosclerosis, associated with contralateral renal artery occlusion: report of a case. (14789332)
1951
48
Nephrosclerosis]. (20271308)
1947
49
Nephrosclerosis, benign and malignant. (20293863)
1947
50
Benign and Malignant Hypertension and Nephrosclerosis: A Clinical and Pathological Study. (19970253)
1936

Variations for Nephrosclerosis

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Expression for genes affiliated with Nephrosclerosis

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Expression patterns in normal tissues for genes affiliated with Nephrosclerosis

Search GEO for disease gene expression data for Nephrosclerosis.

Pathways for genes affiliated with Nephrosclerosis

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Pathways related to Nephrosclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.1TGFB1, ACE
29.1UBD, TGFB1
3
Show member pathways
8.7AGTR1, ACE, TGFB1
4
Show member pathways
8.7UBD, TGFB1, AGTR1
5
Show member pathways
8.1TGFB1, ACE, NR3C2, AGTR1

Compounds for genes affiliated with Nephrosclerosis

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Compounds related to Nephrosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1temocaprilat449.9ACE, AGTR1
2aliskiren44 1110.9ACE, AGTR1
3lacidipine449.9AGTR1, ACE
4angiotensin ii28 2410.8AGTR1, ACE
5omapatrilat449.8ADM, ACE
6saralasin449.8AGTR1, ACE
7eprosartan44 28 1111.8AGTR1, ACE
8cilazapril44 1110.8AGTR1, ACE
9trandolapril44 1110.8AGTR1, ACE
10pd12331944 2810.7ACE, AGTR1
11bradykinin61 28 2411.7AGTR1, ACE
12olmesartan44 28 1111.7ACE, AGTR1
13triamterene44 24 1111.7ACE, NR3C2
14fosinopril44 1110.6AGTR1, ACE
15doxazosin44 1110.5AGTR1, ACE, ADM
16quinapril44 50 1111.5AGTR1, ACE
17carvedilol44 50 28 1112.5ADM, ACE, AGTR1
18nitroglycerin44 1110.5ADM, AGTR1, ACE
19aldosterone28 24 1111.4NR3C2, AGTR1, ADM
20catecholamine449.3ADM, NR3C2, AGTR1
21eplerenone44 61 28 1112.3NR3C2, ACE, AGTR1
22thiazide449.3AGTR1, ACE, NR3C2
23felodipine44 28 1111.3NR3C2, ACE, AGTR1
24hydrochlorothiazide44 28 50 24 1113.3ACE, NR3C2, AGTR1
25enalapril44 50 1111.3ACE, AGTR1, NR3C2
26spironolactone44 61 28 50 1113.3NR3C2, AGTR1, ACE
27prostacyclin449.2ADM, ACE, AGTR1
28sodium nitroprusside449.1AGTR1, ADM, TGFB1
29benazepril44 50 1111.1TGFB1, ACE, AGTR1
30ramipril44 1110.1ACE, TGFB1, AGTR1
31perindopril44 50 1111.1AGTR1, ACE, TGFB1
32candesartan44 50 28 1112.1TGFB1, ACE, AGTR1
33verapamil44 28 50 24 1113.0AGTR1, TGFB1, ACE
34nifedipine44 28 50 1112.0TGFB1, ACE, AGTR1
35captopril44 61 50 28 1112.9AGTR1, NR3C2, ACE, ADM
36norepinephrine44 24 1110.9ADM, NR3C2, ACE, AGTR1
37potassium44 24 1110.9AGTR1, NR3C2, ACE, ADM
38sodium44 249.8NR3C2, ACE, AGTR1, ADM
39cholesterol44 28 24 1111.8NR3C2, ACE, ADM, AGTR1
40acth448.7AGTR1, ADM, NR3C2
41tacrolimus44 50 1110.6AGTR1, TGFB1, NR3C2
42actinomycin d448.6NR3C2, TGFB1, AGTR1, ADM
43cyclosporin a44 28 6110.5AGTR1, NR3C2, ADM, TGFB1
44cycloheximide448.5NR3C2, AGTR1, ADM, TGFB1
45dexamethasone44 50 28 1111.4ADM, TGFB1, NR3C2, AGTR1
46nitric oxide44 24 1110.4ACE, ADM, AGTR1, NR3C2
47alanine448.2AGTR1, TGFB1, NR3C2, ADM
48ang ii448.1TGFB1, NR3C2, ACE, AGTR1, ADM
49losartan44 50 28 1111.1NR3C2, ACE, ADM, TGFB1, AGTR1
50creatinine448.1TGFB1, AGTR1, ADM, ACE, NR3C2

GO Terms for genes affiliated with Nephrosclerosis

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Biological processes related to Nephrosclerosis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1regulation of systemic arterial blood pressure by renin-angiotensinGO:0030819.8AGTR1, ACE
2regulation of vasodilationGO:0423129.7AGTR1, ACE
3regulation of vasoconstrictionGO:0192299.7AGTR1, ACE
4positive regulation of cellular protein metabolic processGO:0322709.4TGFB1, AGTR1
5mononuclear cell proliferationGO:0329439.4ACE, TGFB1
6kidney developmentGO:0018229.4AGTR1, ACE
7organ regenerationGO:0311009.4ADM, TGFB1
8response to woundingGO:0096119.3ADM, TGFB1
9positive regulation of cytosolic calcium ion concentrationGO:0072049.3AGTR1, ADM
10myeloid dendritic cell differentiationGO:0430119.3UBD, TGFB1
11female pregnancyGO:0075659.2TGFB1, ADM
12agingGO:0075689.2ADM, TGFB1
13positive regulation of apoptotic processGO:0430658.9TGFB1, ADM, UBD

Molecular functions related to Nephrosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:0317119.2AGTR1, ACE
2protein bindingGO:0055157.1AGTR1, UBD, NR3C2, ACE, ADM, TGFB1

Products for genes affiliated with Nephrosclerosis

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Sources for Nephrosclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet