MCID: NPH010
MIFTS: 38

Nephrosclerosis malady

Categories: Rare diseases, Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Nephrosclerosis

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Aliases & Descriptions for Nephrosclerosis:

Name: Nephrosclerosis 10 45 47 12 36 65
 
Renal Sclerosis 10

Classifications:



External Ids:

Disease Ontology10 DOID:11664
ICD1027 I12, N26.9
ICD9CM29 587
MeSH36 D009400
UMLS65 C0027719

Summaries for Nephrosclerosis

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Wikipedia:68 Hypertensive nephropathy (or \"hypertensive nephrosclerosis\", or \"Hypertensive kidney disease\") is a... more...

MalaCards based summary: Nephrosclerosis, also known as renal sclerosis, is related to idiopathic hypersomnia and antiphospholipid syndrome. An important gene associated with Nephrosclerosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways are A-beta Pathways: Uptake and Degradation and Renin secretion. Affiliated tissues include kidney, lung and bone, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Related Diseases for Nephrosclerosis

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Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 236)
idRelated DiseaseScoreTop Affiliating Genes
1idiopathic hypersomnia30.2ACE, NR3C2
2antiphospholipid syndrome30.2ACE, AGTR1, TGFB1
3oral squamous cell carcinoma30.0ACE, MTHFR
4ossifying fibroma28.8ACE, AGTR1, CCL2, CTGF, SYNPO, TGFB1
5myocardial infarction28.6ACE, AGTR1, CTGF, MTHFR
6idiopathic membranous glomerulonephritis10.5ACE, AGTR1
7glandular cystitis10.4ACE, AGTR1
8primary non-gestational choriocarcinoma of ovary10.4ACE, TGFB1
9coxa vara, congenital10.4ACE, AGTR1
10ischemic optic neuropathy10.4ACE, AGTR1
11voyeurism10.4ACE, AGTR1
12hypertensive nephropathy10.4
13renal tubular dysgenesis10.3ACE, AGTR1
14endogenous depression10.3ACE, AGTR1
15glomus tympanicum tumor10.3ACE, CCL2
16hiv-110.3
17meningococcemia10.3ADRB1, AGTR1
18fibrosing mediastinitis10.2ACE, AGTR1, TGFB1
19posterior valve urethra10.2ACE, AGTR1, TGFB1
20arthritis10.2
21acute myeloblastic leukemia with maturation10.2ACE, AGTR1
22non-congenital cyst of kidney10.2ACE, AGTR1, TGFB1
23epidermolysis bullosa dystrophica10.2ACE, AGTR1, TGFB1
24crescentic glomerulonephritis10.2CCL2, SYNPO
25malignant acrospiroma10.2ACE, TGFB1, UBD
26oral mucosa leukoplakia10.2ACE, NR3C2
27leukemia10.2
28pancreatitis10.2
29endotheliitis10.2
30episodic ataxia10.2CTGF, TGFB1
31laryngeal tuberculosis10.2CTGF, TGFB1
32pulmonary hypertension10.2CCL2, TGFB1
33aortic dissection lentiginosis10.2ACE, ADRB1, AGTR1
34cerebral lipidosis10.2ACE, ADRB1, AGTR1
35signet ring cell variant cervical mucinous adenocarcinoma10.2ACE, AGTR1
36whipple disease10.1CTGF, TGFB1
37rheumatoid arthritis10.1
38breast cancer10.1
39lymphoma10.1
40esophagitis10.1
41prostatitis10.1
42neuronitis10.1
43iga glomerulonephritis10.1ACE, AGTR1, NR3C2
44craniorachischisis10.1ACE, ADRB1, AGTR1
45abnormal pupillary function10.1ACE, AGTR1, NR3C2
46familial hyperthyroidism due to mutations in tsh receptor10.1AGTR1, NR3C2
47multilocular clear cell renal cell carcinoma10.1ACE, AGTR1, NR3C2
48chronic venous insufficiency10.1ACE, AGTR1, CCL2
49sympathetic ophthalmia10.1AGTR1, NR3C2
50ophthalmia nodosa10.1CTGF, TGFB1

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to nephrosclerosis

Symptoms for Nephrosclerosis

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Drugs & Therapeutics for Nephrosclerosis

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Drugs for Nephrosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Valsartanapproved, investigationalPhase 4268137862-53-460846
Synonyms:
(2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid
(S)-N-Valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine
(S)-N-valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine
(s)-2-(n-((2'-(1h-tetrazol-5-yl)biphenyl-4-yl)methyl)pentanamido)-3-methylbutanoic acid
137862-53-4
AC-4543
AC1L1U1M
AC1Q5QIK
Ambap137862-53-4
Aventis brand of valsartan
BIDD:GT0345
BRD-K45158365-001-02-3
BSPBio_003501
Bio-0796
C081489
C24H29N5O3
CEPA brand of valsartan
CGP 48933
CGP-48933
CHEBI:9927
CHEMBL1069
CID60846
CPD000466318
D00400
DB00177
Diovan
Diovan (TN)
Diovan, Valsartan
Esteve brand of valsartan
HMS1922L21
HMS2051L12
HMS2093K22
HSDB 7519
KBio2_002287
KBio2_004855
KBio2_007423
KBio3_003006
KBioGR_001078
KBioSS_002289
Kalpress
 
L-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI)
LS-161334
Lacer brand of valsartan
MLS000759423
MLS001424088
Miten
MolPort-002-507-854
MolPort-003-666-608
N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine
N-(P-(O-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine
N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine
N-Pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine
N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-L-valine
N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine
N-valeryl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)valine
Nisis
Nisis||
Novartis brand of valsartan
Provas
S1894_Selleck
SAM001246581
SMR000466318
SPBio_001260
SPECTRUM1505209
Sanol brand of valsartan
Schwarz brand of valsartan
Spectrum2_001120
Spectrum3_001831
Spectrum4_000749
Spectrum5_001582
Spectrum_001796
TL8000869
Tareg
UNII-80M03YXJ7I
Vals
Valsarran
Valsartan
Valsartan (JAN/USAN/INN)
Valsartan [USAN:INN]
valsartan
walsartan
|Tareg
2
Angiotensin IIPhase 4103368521-88-0, 11128-99-7172198, 65143
Synonyms:
1-8-Angiotensin I
1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide
Ang II
Angiotensin 2
Angiotensin II (human)
 
Angiotensin II (mouse)
Angiotonin
Asp-arg-val-TYR-ile-his-pro-phe
Human angiotensin II
Hypertensin
Ile(5)-angiotensin II
3AngiotensinogenPhase 41032
4Antihypertensive AgentsPhase 43618
5Angiotensin II Type 1 Receptor BlockersPhase 4949
6Angiotensin Receptor AntagonistsPhase 41039
7BeraprostinvestigationalPhase 2, Phase 31488430-50-66917950
8Vasodilator AgentsPhase 2, Phase 32926
9TezosentanPhase 2, Phase 364
10Platelet Aggregation InhibitorsPhase 2, Phase 31935

Interventional clinical trials:

idNameStatusNCT IDPhase
1Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney DiseaseTerminatedNCT01129557Phase 4
2TRK-100STP Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis)CompletedNCT01090037Phase 2, Phase 3
3TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis)CompletedNCT02480751Phase 2
4Renal NCE-MRI in Healthy VolunteersCompletedNCT02618460

Search NIH Clinical Center for Nephrosclerosis


Cochrane evidence based reviews: nephrosclerosis

Genetic Tests for Nephrosclerosis

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Anatomical Context for Nephrosclerosis

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MalaCards organs/tissues related to Nephrosclerosis:

33
Kidney, Lung, Bone, Testes, Liver, Breast, Prostate

Animal Models for Nephrosclerosis or affiliated genes

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MGI Mouse Phenotypes related to Nephrosclerosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.1ACE, AGTR1, BMP5, NR3C2, SYNPO, TGFB1
2MP:00053857.4ACE, ADRB1, AGTR1, BMP5, CTGF, NR3C2
3MP:00053786.5ACE, ADRB1, AGTR1, BMP5, CTGF, MTHFR

Publications for Nephrosclerosis

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Articles related to Nephrosclerosis:

(show top 50)    (show all 260)
idTitleAuthorsYear
1
Surface tensiometry of apolipoprotein B domains at lipid interfaces suggests a new model for the initial steps in triglyceride-rich lipoprotein assembly. (24515109)
2014
2
Current and future evidence-based acne treatment: a review. (24283604)
2014
3
A case of eosinophilic cystitis in patients with abdominal pain, dysuria, genital skin hyperemia and slight toxocariasis. (23820659)
2013
4
Multiple spots on bone: diagnostic challenge or spot diagnosis? Osteopoikilosis. (24038566)
2013
5
Antero-lateral partial sternotomy for extensive thoracic aortic aneurysm. (23243031)
2013
6
Freehand SPECT-guided sentinel lymph node biopsy in early oral squamous cell carcinoma. (24375962)
2013
7
Inter-centre variability of the adenoma detection rate: a prospective, multicentre study. (23816699)
2013
8
Decreased mRNA expression of PGC-1I+ and PGC-1I+-regulated factors in the SOD1G93A ALS mouse model and in human sporadic ALS. (23147503)
2012
9
Osteosarcoma in a Marfan patient with a novel premature termination codon in the FBN1 gene. (20672986)
2011
10
Surgery alone is adequate treatment for early stage soft tissue sarcoma of the extremity. (20235085)
2010
11
Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs. (19995608)
2010
12
Molecular targeting of carbonic anhydrase IX in mice with hypoxic HT29 colorectal tumor xenografts. (20523727)
2010
13
Complex aortic coarctation and PHACE syndrome. (21070732)
2010
14
Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort. (19268722)
2009
15
Expression of the proneural gene encoding Mash1 suppresses MYCN mitotic activity. (19208763)
2009
16
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi Cells. (19006694)
2008
17
Isokinetic evaluation of knee extensor/flexor muscle strength in patients with hypermobility syndrome. (18043921)
2008
18
BCR-ABL, ETV6-RUNX1 and E2A-PBX1: prevalence of the most common acute lymphoblastic leukemia fusion genes in Mexican patients. (18455790)
2008
19
Hypermethylation of CpG island loci and hypomethylation of LINE-1 and Alu repeats in prostate adenocarcinoma and their relationship to clinicopathological features. (17139617)
2007
20
High frequency of mutation G377S in Brazilian type 3 Gaucher disease patients. (16981045)
2006
21
Bone loss in inflammatory arthritis: mechanisms and therapeutic approaches with bisphosphonates. (16301197)
2005
22
Superinfection of perinephric abscess by Stenotrophomonas maltophilia in a tetraplegic patient. (15672091)
2005
23
A functional polymorphism in the EGF gene is found with increased frequency in glioblastoma multiforme patients and is associated with more aggressive disease. (14973082)
2004
24
Infant botulism: a diagnostic and management challenge. (14671769)
2003
25
A MEK inhibitor (U0126) prolongs survival in nude mice bearing human gallbladder cancer cells with K-ras mutation: analysis in a novel orthotopic inoculation model. (12963974)
2003
26
Systemic nocardiosis in a splenectomized patient with systemic lupus erythematosus: successful treatment using linezolid. (17041423)
2003
27
Perineoplasty for the treatment of introital stenosis related to vulvar lichen sclerosus. (11810083)
2002
28
The Colorado mental retardation and developmental disabilities research center. (12175865)
2002
29
A T2517C polymorphism in the GSTM4 gene is associated with risk of developing lung cancer. (12140136)
2002
30
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. (11441800)
2001
31
Reconsidering the effects of antiresorptive therapies in reducing osteoporotic fracture. (11760829)
2001
32
The lung as a route for systemic delivery of therapeutic proteins and peptides. (11686885)
2001
33
DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance. (11562758)
2001
34
Immunohistochemical analysis of cyclooxygenase (COX)-2 expression in pancreatic endocrine tumors: association with tumor progression and proliferation. (11881729)
2001
35
Prognostic value of immunocytochemical estimation of estrogen receptor (ER) and of pS2 estrogen-dependent protein in cells of mammary ductal carcinoma. Analysis of five-year course of the disease. (11374797)
2001
36
Short-term fasting suppresses leptin and (conversely) activates disorderly growth hormone secretion in midluteal phase women--a clinical research center study. (10084566)
1999
37
Post-transcriptional regulation of bcl-2 in acute myeloblastic leukemia: significance for response to chemotherapy. (8642855)
1996
38
Enhancement of immunostimulatory activity by dual substitution of C8-substituted guanine ribonucleosides: correlation with increased cytokine secretion. (7647961)
1995
39
Cytokines in bronchoalveolar lavage fluid of patients with nocturnal asthma. (7582279)
1995
40
Interleukin-5 upregulates intercellular adhesion molecule-1 gene expression in the nasal mucosa in nasal allergy but not in nonallergic rhinitis. (7819742)
1995
41
Serum erythropoietin levels in term and preterm infants during the first year of life. (8037338)
1994
42
Receptor-mediated gene delivery in vivo. Partial correction of genetic analbuminemia in Nagase rats. (1860843)
1991
43
Preserved striatal tyrosine hydroxylase activity, assessed in vivo, following neonatal hypoxia-ischemia. (1684313)
1991
44
The use of histamine H2-receptor blockaders in the clinical picture of internal diseases]. (1680751)
1991
45
Self-reported diurnal mood changes, early morning awakening and the dexamethasone suppression test in endogenous depression. (3156907)
1985
46
Bicycle and moped spoke injuries in children. Analysis of 103 consecutive cases. (237459)
1975
47
Bilateral metachronous dysgerminoma with a 15-year interval. (5574081)
1971
48
Hormone studies of an ovarian dysgerminoma. (5129555)
1971
49
Granuloma inguinale treated with streptomycin. (18890556)
1948
50
A case of severe pre-eclamptic toxaemia with central placenta praevia. (18895818)
1947

Variations for Nephrosclerosis

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Expression for genes affiliated with Nephrosclerosis

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Search GEO for disease gene expression data for Nephrosclerosis.

Pathways for genes affiliated with Nephrosclerosis

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GO Terms for genes affiliated with Nephrosclerosis

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Biological processes related to Nephrosclerosis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:003294310.5ACE, TGFB1
2positive regulation of cellular protein metabolic processGO:003227010.3AGTR1, TGFB1
3positive regulation of collagen biosynthetic processGO:003296710.2CCL2, TGFB1
4cellular response to organic cyclic compoundGO:007140710.1CCL2, TGFB1
5organ regenerationGO:003110010.1CCL2, TGFB1
6SMAD protein signal transductionGO:006039510.0BMP5, TGFB1
7response to progesteroneGO:003257010.0CCL2, TGFB1
8positive regulation of pathway-restricted SMAD protein phosphorylationGO:001086210.0BMP5, TGFB1
9growthGO:004000710.0BMP5, TGFB1
10myeloid dendritic cell differentiationGO:004301110.0TGFB1, UBD
11regulation of vasoconstrictionGO:00192299.9ACE, AGTR1
12lipopolysaccharide-mediated signaling pathwayGO:00316639.8CCL2, TGFB1
13response to woundingGO:00096119.4CCL2, CTGF, TGFB1
14cellular response to dexamethasone stimulusGO:00715499.4CCL2, TGFB1
15response to drugGO:00424939.0CCL2, MTHFR, TGFB1

Sources for Nephrosclerosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet