MCID: NPH010
MIFTS: 56

Nephrosclerosis malady

Nephrological diseases category

Summaries for Nephrosclerosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Hypertensive nephropathy (or \"hypertensive nephrosclerosis\", or \"Hypertensive renal disease\") is a... more...

MalaCards: Nephrosclerosis, also known as renal sclerosis, unspecified, is related to hypertension and renal hypertension. An important gene associated with Nephrosclerosis is ADM (adrenomedullin), and among its related pathways are Renin-angiotensin system and Calcitonin-like ligand receptors. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include kidney, pituitary and heart, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Aliases & Classifications for Nephrosclerosis

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

nephrosclerosis 8 42 44 60
renal sclerosis, unspecified 8
renal sclerosis unspecified 8
renal sclerosis nos 8
renal sclerosis 8


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Disease Ontology8 DOID:11664
ICD9CM27 587
MeSH34 D009400

Related Diseases for Nephrosclerosis

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17GeneCards, 18GeneDecks
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Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.3TGFB1, ADM, ADRB1, ACE2, ACE, AGTR1
2renal hypertension30.9ADM, ACE
3malignant hypertension30.6ADM, ADAMTS13, ACE
4glomerulonephritis30.4TGFB1, AGTR1, SYNPO, MPO, LPA, CTGF
5proteinuria30.4TGFB1, ADM, ADAMTS13, ACE2, ACE, AGTR1
6hemolytic-uremic syndrome30.3ADAMTS13
7arteriosclerosis30.2ADM
8uremia30.1ALAD, LPA, LCAT
9ischemia30.1CTGF, BMP7, MPO, ADM, ADAMTS13, NR3C2
10essential hypertension30.1LCAT, LPA, NR3C2, AGTR1, ACE, ACE2
11hypertensive heart disease30.0NR3C2, AGTR1, ACE
12atherosclerosis30.0LCAT, CTGF, LPA, MPO, NR3C2, AGTR1
13acute pancreatitis29.8MPO
14pancreatitis29.8TGFB1, MPO
15renal vascular disease29.8ACE
16renovascular hypertension29.8ADM, ACE, AGTR1
17hyperaldosteronism29.8NR3C2, AGTR1, ACE
18leukemia29.8MPO, NR3C2, TGFB1
19iga glomerulonephritis29.8AGTR1, ACE, ADM, TGFB1
20diabetic retinopathy29.8CTGF, AGTR1, THBS1, ACE, ADM
21obesity29.8LCAT, LPA, NR3C2, THBS1, ADRB1
22vascular disease29.8LCAT, CTGF, LPA, NR3C2, AGTR1, ACE
23chronic kidney failure29.8TGFB1, ADM, ADAMTS13, ALAD, ACE, AGTR1
24diabetes mellitus29.8TGFB1, SERPINC1, ACE, AGTR1, NR3C2, LPA
25kidney disease10.2
26pyelonephritis10.2
27cerebritis10.1
28focal glomerulosclerosis10.0
29chronic pyelonephritis10.0
30tuberculosis10.0
31lung cancer10.0TGFB1
32cor pulmonale10.0AGTR1
33pulmonary disease, chronic obstructive10.0TGFB1
34multiple sclerosis10.0TGFB1
35anuria10.0ACE
36chagas disease10.0ADRB1
37primary pulmonary hypertension10.0ADM
38polycystic ovary syndrome10.0NR3C2
39vesicoureteral reflux10.0AGTR1
40severe acute respiratory syndrome10.0ACE2
41cholestasis10.0LCAT
42hypothyroidism10.0LPA
43oligohydramnios10.0ACE
44myocarditis10.0ADRB1
45intracranial aneurysm10.0ACE2
46myelofibrosis10.0TGFB1
47urticaria10.0ACE
48lupus erythematosus10.0SERPINC1
49cystic fibrosis10.0MPO
50acromegaly10.0LPA

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to nephrosclerosis

Clinical Features for Nephrosclerosis

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Drugs & Therapeutics for Nephrosclerosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Nephrosclerosis

Drug clinical trials:

Search ClinicalTrials for Nephrosclerosis

Search NIH Clinical Center for Nephrosclerosis

Search CenterWatch for Nephrosclerosis

Genetic Tests for Nephrosclerosis

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Anatomical Context for Nephrosclerosis

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32MalaCards
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MalaCards organs/tissues related to Nephrosclerosis:

32
Kidney, Pituitary, Heart, Bone, Smooth muscle, Pancreas, Testes, Spleen, Endothelial

Animal Models for Nephrosclerosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nephrosclerosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.7TGFB1, BMP5, BMP7
2MP:00053699.6THBS1, ACE2, ADRB1, TGFB1
3MP:00053889.6CTGF, BMP7, THBS1, ACE2, TGFB1
4MP:00053709.3LCAT, BMP5, THBS1, ACE, SERPINC1, ADM
5MP:00053679.2ADM, BMP7, BMP5, SYNPO, NR3C2, AGTR1
6MP:00053809.2CTGF, BMP7, BMP5, SERPINC1, ADM, TGFB1
7MP:00053878.7UBD, BMP7, BMP5, MPO, AGTR1, THBS1
8MP:00053768.1AGTR1, NR3C2, MPO, CTGF, CALCA, LCAT
9MP:00053858.0MPO, BMP5, BMP7, CTGF, CALCA, LCAT
10MP:00107688.0NR3C2, MPO, BMP5, BMP7, CTGF, CALCA

Publications for Nephrosclerosis

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50PubMed
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Articles related to Nephrosclerosis:

(show top 50)    (show all 254)
idTitleAuthorsYear
1
Effect of intensive blood pressure control on cardiovascular remodeling in hypertensive patients with nephrosclerosis. (24102027)
2013
2
Need for education on the differential diagnosis between chronic glomerulonephritis and nephrosclerosis, and treatment of both conditions to reduce the number of patients requiring hemodialysis in Wakayama. (22821095)
2012
3
Hypertensive nephrosclerosis in Kenya. (22179094)
2011
4
Senile nephrosclerosis--does it explain the decline in glomerular filtration rate with aging? (21832860)
2011
5
Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. (21080950)
2010
6
Angiotensin II formation in the kidney and nephrosclerosis in Ren-2 hypertensive rats. (16522658)
2006
7
'Primary' nephrosclerosis in a type 1 diabetic patient. (15772267)
2005
8
The MTHFR 677TT and 677CT/1298AC genotypes in Cypriot patients may be predisposing to hypertensive nephrosclerosis and chronic renal failure. (16158041)
2005
9
Myeloperoxidase-antineutrophil cytoplasmic antibody-associated glomerulonephritis superimposed on biopsy-proven diabetic nephrosclerosis. (11774130)
2002
10
Intrauterine food restriction as a determinant of nephrosclerosis. (11228169)
2001
11
Comparison of cross-sectional renal function measurements in African Americans with hypertensive nephrosclerosis and of primary formulas to estimate glomerular filtration rate. (11576877)
2001
12
Increased fibrinogen levels and hemostatic abnormalities in patients with arteriolar nephrosclerosis: association with cardiovascular events. (11057851)
2000
13
The clinical diagnosis of hypertensive nephrosclerosis--how reliable is it? (10069175)
1999
14
Mibefradil prevents L-NAME-exacerbated nephrosclerosis in spontaneously hypertensive rats. (10526911)
1999
15
Hormonal disorders in patients with chronic pyelonephritis with nephrosclerosis and kidney failure]. (9621641)
1998
16
The long-term prognosis of benign nephrosclerosis accompanied by focal glomerulosclerosis and renal cortical interstitial fibrosis, designated so-called decompensated benign nephrosclerosis by Fahr, Bohle and Ratscheck. (9779492)
1998
17
Effects of the novel multiple-action agent carvedilol on severe nephrosclerosis in renal ablated rats. (9336341)
1997
18
Nephrosclerosis and hypertension. (9356598)
1997
19
Effects of novel, nonpeptide vasopressin antagonists on progressive nephrosclerosis in rats. (7630164)
1995
20
Nephrosclerosis, glycohemoglobin, cholesterol, and smoking in subjects dying of coronary heart disease. (8058701)
1994
21
Renal ablation acutely transforms 'benign' hypertension to 'malignant' nephrosclerosis in hypertensive rats. (8082937)
1994
22
The diagnostic dilemma of hypertensive nephrosclerosis: the nephrologist's view. (8494026)
1993
23
On benign and malignant nephrosclerosis. (3154292)
1988
24
Morphometrical and functional correlations in benign nephrosclerosis. (3427833)
1987
25
Hemolytic uremic syndrome after ectopic pregnancy: postectopic nephrosclerosis. (3808522)
1987
26
Proteinuria in benign nephrosclerosis. (3729631)
1986
27
Marked proteinuria in hypertensive nephrosclerosis. (3160240)
1985
28
Recovery of renal function in patients with accelerated malignant nephrosclerosis on maintenance dialysis with management of blood pressure by captopril. (3900778)
1985
29
An accelerated hypertension with neither malignant nephrosclerosis nor elevation of plasma renin activity. (650894)
1978
30
Arteriolar nephrosclerosis in the Syrian hamster. (625859)
1978
31
Asymmetrical interlobar nephrosclerosis. (4131975)
1974
32
Nephrosclerosis and blood pressure. II. Reversibility of proliferative arteriosclerosis. (4130305)
1974
33
Correlation of lengthy hospital records of blood pressure with nephrosclerosis. (5415574)
1970
34
Nephrosclerosis--the persistent question. (5467549)
1970
35
Malignant nephrosclerosis in women post partum. A note on microangiopathic hemolytic anemia. (5006762)
1967
36
RHEUMATIC NEPHROSCLEROSIS WITH SPECIAL REFERENCE TO RHEUMATIC ENDARTERITIS. (14297514)
1965
37
IMMUNOCYTOCHEMICAL OBSERVATIONS ON THE VASCULAR NECROSIS AND RENAL GLOMERULAR LESIONS OF MALIGNANT NEPHROSCLEROSIS. (14328020)
1965
38
Renal angiography in pyelonephritis, glomerulonephritis, and arteriolar nephrosclerosis. (5832183)
1965
39
MALIGNANT NEPHROSCLEROSIS IN THE WHITE AND NEGRO RACES. (14103117)
1963
40
Late effects of fast neutrons versus x-rays in mice: nephrosclerosis, tumors, longevity. (14427845)
1959
41
Late effects of total-body roentgen irradiation. V. Longevity and incidence of nephrosclerosis as influenced by partial-body shielding. (13665334)
1959
42
Unilateral malignant nephrosclerosis in a child. (13212556)
1954
43
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952
44
WEEKLY clinicopathological exercises: malignant nephrosclerosis (uremia with base losing nephropathy). (14899643)
1952
45
Unilateral renal cortical necrosis and unilateral benign and malignant nephrosclerosis, associated with contralateral renal artery occlusion: report of a case. (14789332)
1951
46
WEEKLY clinicopathological exercises: miliary tuberculosis; nephrosclerosis and pyelonephritis, hypertensive heart disease, mild. (14780393)
1950
47
Unilateral malignant nephrosclerosis. (18144080)
1949
48
Can the administration of desoxycorticosterone acetate give rise to nephrosclerosis? (18112213)
1949
49
Malignant nephrosclerosis in pregnancy. (18135965)
1949
50
The assay of nephrosclerosis producing anterior pituitary preparations. (21000751)
1946

Genetic Variations for Nephrosclerosis

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Expression for genes affiliated with Nephrosclerosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephrosclerosis

Search GEO for disease gene expression data for Nephrosclerosis.

Pathways for genes affiliated with Nephrosclerosis

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Sources:
29KEGG, 53Reactome, 55SinoBiological, 49PharmGKB, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Nephrosclerosis

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44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Nephrosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1pge24410.7TGFB1
2estrogen4410.5LPA, LCAT
3benazepril44 1111.4AGTR1, TGFB1, ACE
4procollagen4410.4TGFB1
5angiotensin ii28 2411.3ACE2, ACE, AGTR1
6carvedilol44 49 28 1113.3ADRB1, ADM, ACE, AGTR1
7aldosterone28 11 2412.3ADM, AGTR1, CTGF, NR3C2
8clonidine44 28 1112.3CALCA, ADRB1, AGTR1
9eplerenone44 59 28 1113.3NR3C2, AGTR1, ACE, ACE2
10thiazide4410.2CALCA, ACE, AGTR1, NR3C2
11ramipril44 1111.2TGFB1, ACE, AGTR1, ACE2
12superoxide44 2411.2LPA, NR3C2, ALAD, AGTR1
13nitroglycerin44 1111.2AGTR1, ACE, CALCA, ADM
14lisinopril44 11 2412.2AGTR1, ACE2, ACE
15norepinephrine44 11 2412.2CALCA, NR3C2, ADRB1, ADM
16amiloride44 28 1112.1TGFB1, NR3C2, MPO, CTGF
17methacholine44 1111.1TGFB1, AGTR1, MPO, CALCA
18ang ii4410.1ADM, CTGF, AGTR1, ACE, TGFB1, NR3C2
19losartan44 49 28 1113.0NR3C2, CTGF, AGTR1, ADM, TGFB1, ACE
20vitamin d4410.0AGTR1, NR3C2, CALCA, THBS1, ALAD
21malondialdehyde4410.0ALAD, ADM, LPA, MPO
22thiorphan44 28 1112.0ADM, ACE, CALCA
23captopril44 28 49 59 1114.0ADM, ACE2, CTGF, NR3C2, CALCA
24tgf beta14410.0TGFB1, THBS1, CTGF, BMP7, AGTR1
25kininogen4410.0SERPINC1, ACE, THBS1, MPO
26potassium44 11 2411.9ALAD, ACE, AGTR1, NR3C2, ADM, ADRB1
27dexamethasone44 49 28 1112.9BMP7, TGFB1, LCAT, NR3C2, ADRB1, CTGF
28propranolol44 28 49 11 2413.9CALCA, MPO, ADRB1, ADM
29prostacyclin449.9ACE, ADM, SERPINC1, CTGF, AGTR1, THBS1
30acth449.9ADM, LPA, NR3C2, AGTR1, CALCA
31cyclosporin a44 28 5911.8CALCA, ADM, ADAMTS13, CTGF, THBS1, NR3C2
32oxygen44 2410.8BMP7, MPO, NR3C2, ACE2, ADRB1, ADM
33atenolol44 28 49 11 2413.8AGTR1, ACE, ADRB1
34heparin44 28 11 2412.8LCAT, CTGF, BMP7, MPO, ADAMTS13, LPA
35aspirin44 49 28 2412.7AGTR1, TGFB1, SERPINC1, ACE, LPA
36fibrinogen449.7LPA, AGTR1, THBS1, CTGF, ADAMTS13, SERPINC1
37pravastatin44 49 28 11 2413.7CTGF, LCAT, AGTR1, LPA
38chloride449.7NR3C2, LPA, MPO, ADAMTS13, ACE2
39creatinine449.6ADAMTS13, ACE, BMP7, LPA, SYNPO, TGFB1
40alanine449.6NR3C2, AGTR1, ADM, LCAT, TGFB1, ADRB1
41cholesterol44 28 11 2412.5ADM, ACE2, AGTR1, NR3C2, THBS1, LPA
42testosterone44 59 11 2412.5CALCA, NR3C2, THBS1, ADM, ALAD, LCAT
43glucose449.4CTGF, ADRB1, ACE, AGTR1, NR3C2, LPA
44lactate449.4ALAD, TGFB1, ADM, CALCA, MPO, CTGF
45retinoic acid44 2410.4BMP7, MPO, NR3C2, ADRB1, THBS1, TGFB1
46lipid449.2LCAT, BMP7, LPA, THBS1, CTGF, ACE
47serine449.2LCAT, CTGF, BMP7, THBS1, NR3C2, TGFB1
48vegf449.0LPA, BMP7, CTGF, CALCA, AGTR1, THBS1
49nitric oxide44 11 2410.8ALAD, NR3C2, AGTR1, THBS1, ACE, MPO
50calcium44 49 11 2411.8CALCA, MPO, ADRB1, ADAMTS13, ALAD, ACE

GO Terms for genes affiliated with Nephrosclerosis

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16Gene Ontology
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Cellular components related to Nephrosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4ADM, SERPINC1, ACE2, ACE, THBS1, LPA
2extracellular spaceGO:0056157.7LCAT, ADAMTS13, SERPINC1, ACE2, ACE, THBS1

Biological processes related to Nephrosclerosis according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:03294310.5TGFB1, ACE
2peptide catabolic processGO:04317110.5ADAMTS13, ACE
3angiotensin catabolic process in bloodGO:00200510.4ACE2, ACE
4positive regulation of fibroblast migrationGO:01076310.4TGFB1, THBS1
5negative regulation of smooth muscle contractionGO:04598610.4ADRB1, CALCA
6positive regulation of chemotaxisGO:05092110.3THBS1, TGFB1
7regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.3ACE2, ACE, AGTR1
8regulation of vasodilationGO:04231210.3ACE2, ACE, AGTR1
9positive regulation of dendrite developmentGO:190000610.3BMP7, BMP5
10regulation of vasoconstrictionGO:01922910.3AGTR1, ACE, ACE2
11positive regulation of pathway-restricted SMAD protein phosphorylationGO:01086210.3TGFB1, BMP5, BMP7
12positive regulation of cellular protein metabolic processGO:03227010.3AGTR1, TGFB1
13response to woundingGO:00961110.3CTGF, ADM, TGFB1
14positive regulation of cAMP biosynthetic processGO:03081910.3ADM, ADRB1, CALCA
15G-protein coupled receptor internalizationGO:00203110.3ADM, CALCA
16low-density lipoprotein particle remodelingGO:03437410.3AGTR1, MPO
17positive regulation of reactive oxygen species metabolic processGO:200037910.3AGTR1, THBS1, ACE2
18response to glucose stimulusGO:00974910.2TGFB1, THBS1, CTGF
19agingGO:00756810.2TGFB1, ADM, ADRB1, CALCA
20regulation of inflammatory responseGO:05072710.2CALCA, AGTR1, ACE2
21angiotensin maturationGO:00200310.2ACE, ACE2
22ossificationGO:00150310.1BMP5, BMP7, CTGF
23negative regulation of blood vessel endothelial cell migrationGO:04353710.1THBS1, TGFB1
24elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.1AGTR1, CALCA
25positive regulation of peptidyl-threonine phosphorylationGO:01080010.1BMP7, TGFB1
26proteolysisGO:0065089.8UBD, LPA, ACE, ACE2, ADAMTS13
27elevation of cytosolic calcium ion concentrationGO:0072049.7ADM, AGTR1, CALCA

Molecular functions related to Nephrosclerosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:03171110.3ACE, AGTR1
2peptidyl-dipeptidase activityGO:00824110.1ACE, ACE2
3fibronectin bindingGO:00196810.0THBS1, LPA, CTGF
4integrin bindingGO:0051789.9ADAMTS13, THBS1, CTGF
5growth factor activityGO:0080839.7TGFB1, BMP5, BMP7, CTGF
6metallopeptidase activityGO:0082379.6ACE, ACE2, ADAMTS13
7heparin bindingGO:0082019.6SERPINC1, THBS1, MPO, LPA, CTGF
8protein bindingGO:0055158.1SYNPO, BMP7, CTGF, UBD, CALCA, LCAT

Products for genes affiliated with Nephrosclerosis

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Sources for Nephrosclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet