MCID: NPH010
MIFTS: 46

Nephrosclerosis

Categories: Rare diseases, Nephrological diseases, Cardiovascular diseases

Aliases & Classifications for Nephrosclerosis

MalaCards integrated aliases for Nephrosclerosis:

Name: Nephrosclerosis 12 72 49 28 51 41 14 69
Renal Sclerosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11664
ICD10 32 I12 N26.9
ICD9CM 34 587
MeSH 41 D009400
UMLS 69 C0027719

Summaries for Nephrosclerosis

MalaCards based summary : Nephrosclerosis, also known as renal sclerosis, is related to glomerulonephritis and malignant hypertension. An important gene associated with Nephrosclerosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are p70S6K Signaling and Dilated cardiomyopathy (DCM). The drugs Angiotensin II and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include kidney, pituitary and heart, and related phenotypes are cardiovascular system and growth/size/body region

Wikipedia : 72 Hypertensive kidney disease is a medical condition referring to damage to the kidney due to chronic high... more...

Related Diseases for Nephrosclerosis

Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 glomerulonephritis 30.2 CCL2 NPHS2 TGFB1
2 malignant hypertension 30.1 ACE ADAMTS13 AGTR1
3 renal hypertension 30.0 ACE AGTR1
4 hypertensive heart disease 29.8 ACE AGTR1 NR3C2
5 chronic kidney failure 29.8 ACE AGTR1 NPHS2
6 renovascular hypertension 29.6 ACE AGTR1
7 end stage renal failure 29.5 ACE AGTR1 NPHS2 TGFB1
8 hypertension, essential 29.3 ACE ADRB1 AGTR1 NR3C2
9 microvascular complications of diabetes 3 29.2 ACE AGTR1 CTGF TGFB1
10 iga glomerulonephritis 29.1 ACE AGTR1 CCL2 NPHS2 TGFB1
11 heart disease 28.5 ACE ADRB1 AGTR1 MTHFR NR3C2
12 familial vesicoureteral reflux 10.5 ACE TGFB1
13 renal artery disease 10.5 ACE AGTR1
14 hypertensive nephropathy 10.4 ACE AGTR1
15 posterior urethral valves 10.3 ACE AGTR1 TGFB1
16 meningococcal infection 10.3 ADRB1 AGTR1
17 peyronie's disease 10.3 CCL2 TGFB1
18 fibromuscular dysplasia 10.3 ACE AGTR1 TGFB1
19 oligohydramnios 10.3 ACE AGTR1
20 tuberculous meningitis 10.3 CCL2 TGFB1
21 diffuse mesangial sclerosis 10.3 NPHS2 TGFB1
22 otosclerosis 10.3 ACE AGTR1 TGFB1
23 evans' syndrome 10.2 ADAMTS13 TGFB1
24 idiopathic edema 10.2 ACE NR3C2
25 silicosis 10.2 ACE CCL2 TGFB1
26 pauci-immune glomerulonephritis 10.2 CTGF SYNPO
27 aortic coarctation 10.2 ACE ADRB1 AGTR1
28 cholecystolithiasis 10.2 CTGF TGFB1
29 stiff skin syndrome 10.2 CTGF TGFB1
30 lipoid nephrosis 10.1 CCL2 NPHS2 SYNPO
31 kidney hypertrophy 10.1 CTGF NPHS2
32 crescentic glomerulonephritis 10.1 CCL2 NPHS2 SYNPO
33 anuria 10.1 ACE AGTR1 NR3C2
34 conn's syndrome 10.1 ACE AGTR1 NR3C2
35 atrial fibrillation 10.1 ACE ADRB1 AGTR1
36 cerebral atherosclerosis 10.1 ACE MTHFR
37 diastolic heart failure 10.1 ACE AGTR1 CTGF
38 retinal artery occlusion 10.0 ACE MTHFR
39 aging 10.0
40 systemic scleroderma 10.0 ACE CTGF TGFB1
41 kidney disease 10.0
42 focal segmental glomerulosclerosis 10.0 ACE NPHS2 SYNPO TGFB1
43 systolic heart failure 10.0 ACE ADRB1 NR3C2
44 gingival disease 10.0 CTGF TGFB1
45 hemolytic-uremic syndrome 10.0
46 vitreoretinopathy, neovascular inflammatory 9.9 CCL2 CTGF TGFB1
47 urinary tract obstruction 9.9 CCL2 CTGF TGFB1
48 retinal vascular occlusion 9.9 CCL2 MTHFR
49 idiopathic interstitial pneumonia 9.9 CCL2 CTGF TGFB1
50 pulmonary fibrosis 9.9 CCL2 CTGF TGFB1

Comorbidity relations with Nephrosclerosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Heart Disease Hydronephrosis
Hypertension, Essential Ischemic Heart Disease
Kidney Disease Nephrolithiasis, X-Linked Recessive, with Renal Failure

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to Nephrosclerosis

Symptoms & Phenotypes for Nephrosclerosis

MGI Mouse Phenotypes related to Nephrosclerosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 BMP5 CTGF NPHS2 ACE NR3C2 ADRB1
2 growth/size/body region MP:0005378 9.91 BMP5 CTGF MTHFR NPHS2 ACE NR3C2
3 homeostasis/metabolism MP:0005376 9.81 CTGF MTHFR NPHS2 ACE ADAMTS13 NR3C2
4 mortality/aging MP:0010768 9.65 BMP5 CTGF MTHFR NPHS2 ACE NR3C2
5 renal/urinary system MP:0005367 9.17 BMP5 NPHS2 ACE NR3C2 SYNPO TGFB1

Drugs & Therapeutics for Nephrosclerosis

Drugs for Nephrosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
2
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
3 Antihypertensive Agents Phase 4,Phase 2,Phase 3
4 Angiotensin II Type 1 Receptor Blockers Phase 4
5 Angiotensin Receptor Antagonists Phase 4
6 Angiotensinogen Phase 4
7
Epoprostenol Approved Phase 2, Phase 3 61849-14-7, 35121-78-9 5282411 5280427
8 Beraprost Investigational Phase 2, Phase 3 88430-50-6
9 Platelet Aggregation Inhibitors Phase 2, Phase 3
10 Tezosentan Phase 2, Phase 3
11 Vasodilator Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease Terminated NCT01129557 Phase 4 Aliskiren;Valsartan
2 TRK-100STP Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT01090037 Phase 2, Phase 3 TRK-100STP high dose;TRK-100STP low dose;Placebo
3 TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT02480751 Phase 2 Beraprost;Placebo
4 Renal NCE-MRI in Healthy Volunteers Completed NCT02618460

Search NIH Clinical Center for Nephrosclerosis

Cochrane evidence based reviews: nephrosclerosis

Genetic Tests for Nephrosclerosis

Genetic tests related to Nephrosclerosis:

# Genetic test Affiliating Genes
1 Nephrosclerosis 28

Anatomical Context for Nephrosclerosis

MalaCards organs/tissues related to Nephrosclerosis:

38
Kidney, Pituitary, Heart, Pancreas, Bone, Smooth Muscle, Endothelial

Publications for Nephrosclerosis

Articles related to Nephrosclerosis:

(show top 50) (show all 273)
# Title Authors Year
1
Investigation into the underlying molecular mechanisms of hypertensive nephrosclerosis using bioinformatics analyses. ( 29328390 )
2018
2
Nationwide multicenter kidney biopsy study of Japanese patients with hypertensive nephrosclerosis. ( 29127556 )
2017
3
Comparison of Clinical Trajectories before Initiation of Renal Replacement Therapy between Diabetic Nephropathy and Nephrosclerosis on the KDIGO Guidelines Heat Map. ( 26839894 )
2016
4
Hyperuricemia as a Predictive Marker for Progression of Nephrosclerosis: Clinical Assessment of Prognostic Factors in Biopsy-Proven Arterial/Arteriolar Nephrosclerosis. ( 27784849 )
2016
5
Detection and Clinical Patterns of Nephron Hypertrophy and Nephrosclerosis Among Apparently Healthy Adults. ( 26857648 )
2016
6
Curcumin ameliorates nephrosclerosis via suppression of histone acetylation independent of hypertension. ( 27190365 )
2016
7
Clinico-pathological characteristics and outcomes of patients with biopsy-proven hypertensive nephrosclerosis: a retrospective cohort study. ( 27066888 )
2016
8
Effect of Proteinuria and Glomerular Filtration Rate on Renal Outcome in Patients with Biopsy-Proven Benign Nephrosclerosis. ( 26809068 )
2016
9
Malignant nephrosclerosis in a patient with familial Mediterranean fever. ( 26466703 )
2015
10
Nephrosclerosis: A Term in Quest of a Disease. ( 25871843 )
2015
11
Glomerular Density in Biopsy-Proven Hypertensive Nephrosclerosis. ( 25631380 )
2015
12
The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis. ( 26557147 )
2015
13
Patients with biopsy-proven nephrosclerosis and moderately impaired renal function have a higher risk for cardiovascular disease: 15 years' experience in a single, kidney disease center. ( 25838316 )
2015
14
Nephrosclerosis: update on a centenarian. ( 25488894 )
2014
15
Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model. ( 24958497 )
2014
16
A multinational phase IIb/III trial of beraprost sodium, an orally active prostacyclin analogue, in patients with primary glomerular disease or nephrosclerosis (CASSIOPEIR trial), rationale and study design. ( 25233856 )
2014
17
Effect of intensive blood pressure control on cardiovascular remodeling in hypertensive patients with nephrosclerosis. ( 24102027 )
2013
18
Vildagliptin restores renal myogenic function and attenuates renal sclerosis independently of effects on blood glucose or proteinuria in Zucker Diabetic Fatty rat. ( 24066937 )
2013
19
Involvement of apoptosis inhibitor of macrophages in a rat hypertension model with nephrosclerosis: possible mechanisms of action of olmesartan and azelnidipine. ( 23902971 )
2013
20
Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis. ( 23151750 )
2013
21
Hypertensive nephrosclerosis: not enough of a good thing? ( 23283991 )
2013
22
Endothelial Sirtuin 1 Deficiency Perpetrates Nephrosclerosis through Downregulation of Matrix Metalloproteinase-14: Relevance to Fibrosis of Vascular Senescence. ( 24136919 )
2013
23
Castleman's disease accompanied by hypolipidemic cerebral hemorrhage and nephrosclerosis. ( 23857095 )
2013
24
Aliskiren reduces home blood pressure and albuminuria in patients with hypertensive nephrosclerosis. ( 23135868 )
2013
25
Prevalence and risk factor analysis of nephrosclerosis and ischemic nephropathy in the Japanese general population. ( 23832327 )
2013
26
Subclinical nephrosclerosis is linked to left ventricular hypertrophy independent of classical atherogenic factors. ( 24305517 )
2013
27
Hypertension, glomerular hypertrophy and nephrosclerosis: the effect of race. ( 24327566 )
2013
28
Arteriolar vascular smooth muscle cell differentiation in benign nephrosclerosis. ( 22319217 )
2012
29
Need for education on the differential diagnosis between chronic glomerulonephritis and nephrosclerosis, and treatment of both conditions to reduce the number of patients requiring hemodialysis in Wakayama. ( 22821095 )
2012
30
Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis. ( 22236281 )
2012
31
Involvement of connective tissue growth factor in human and experimental hypertensive nephrosclerosis. ( 20689330 )
2011
32
Senile nephrosclerosis--does it explain the decline in glomerular filtration rate with aging? ( 21832860 )
2011
33
Nephrosclerosis and carotid atherosclerosis: lessons from kidney donor histology. ( 21777346 )
2011
34
Hypertensive nephrosclerosis in Kenya. ( 22179094 )
2011
35
Expression of ACE and ACE2 in patients with hypertensive nephrosclerosis. ( 21346373 )
2011
36
ADAMTS13--marker of contractile phenotype of arterial smooth muscle cells lost in benign nephrosclerosis. ( 20923926 )
2011
37
The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. ( 21319131 )
2011
38
Rate of ESRD exceeds mortality among African Americans with hypertensive nephrosclerosis. ( 20651163 )
2010
39
Intrarenal expression of miRNAs in patients with hypertensive nephrosclerosis. ( 19910931 )
2010
40
Relationship between body mass index and proteinuria in hypertensive nephrosclerosis: results from the African American Study of Kidney Disease and Hypertension (AASK) cohort. ( 20801567 )
2010
41
The association between age and nephrosclerosis on renal biopsy among healthy adults. ( 20439574 )
2010
42
Human nephrosclerosis triggers a hypoxia-related glomerulopathy. ( 20019191 )
2010
43
Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. ( 21080950 )
2010
44
Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis. ( 20484896 )
2010
45
[Molecular factors of angiogenesis in renal tissue of patients with chronic glomerulonephritis: association with nephrosclerosis and anemia]. ( 19799194 )
2009
46
Podocyte loss in human hypertensive nephrosclerosis. ( 19131934 )
2009
47
Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. ( 19745105 )
2009
48
Renal dysplasia and nephrosclerosis in calves. ( 19933543 )
2009
49
(Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. ( 18212268 )
2008
50
Hypertensive nephrosclerosis. ( 18408477 )
2008

Variations for Nephrosclerosis

Expression for Nephrosclerosis

Search GEO for disease gene expression data for Nephrosclerosis.

Pathways for Nephrosclerosis

GO Terms for Nephrosclerosis

Cellular components related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 ACE ADAMTS13 BMP5 CCL2 CTGF TGFB1

Biological processes related to Nephrosclerosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.67 BMP5 CCL2 CTGF TGFB1
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.65 CCL2 CTGF TGFB1
3 response to amino acid GO:0043200 9.49 CTGF MTHFR
4 lipopolysaccharide-mediated signaling pathway GO:0031663 9.46 CCL2 TGFB1
5 regulation of vasoconstriction GO:0019229 9.43 ACE AGTR1
6 positive regulation of collagen biosynthetic process GO:0032967 9.4 CTGF TGFB1
7 peptide catabolic process GO:0043171 9.32 ACE ADAMTS13
8 positive regulation of cellular protein metabolic process GO:0032270 9.26 AGTR1 TGFB1
9 regulation of blood vessel diameter GO:0097746 9.16 ACE AGTR1
10 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 8.96 ACE AGTR1
11 mononuclear cell proliferation GO:0032943 8.62 ACE TGFB1

Molecular functions related to Nephrosclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.33 BMP5 CCL2 TGFB1
2 growth factor activity GO:0008083 9.13 BMP5 CTGF TGFB1
3 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Nephrosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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