MCID: NPH010
MIFTS: 44

Nephrosclerosis malady

Categories: Rare diseases, Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Nephrosclerosis

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Aliases & Descriptions for Nephrosclerosis:

Name: Nephrosclerosis 10 45 47 12 36 65
 
Renal Sclerosis 10

Classifications:



External Ids:

Disease Ontology10 DOID:11664
ICD1027 I12, N26.9
ICD9CM29 587
MeSH36 D009400
UMLS65 C0027719

Summaries for Nephrosclerosis

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Wikipedia:68 Hypertensive nephropathy (or \"hypertensive nephrosclerosis\", or \"Hypertensive kidney disease\") is a... more...

MalaCards based summary: Nephrosclerosis, also known as renal sclerosis, is related to iga glomerulonephritis and arteriosclerosis. An important gene associated with Nephrosclerosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways are A-beta Pathways: Uptake and Degradation and Renin secretion. Affiliated tissues include kidney, prostate and pituitary, and related mouse phenotypes are renal/urinary system and cardiovascular system.

Related Diseases for Nephrosclerosis

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Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1iga glomerulonephritis29.8ACE, AGTR1, NR3C2
2arteriosclerosis29.6ACE, MTHFR
3idiopathic membranous glomerulonephritis10.7ACE, AGTR1
4glandular cystitis10.7ACE, AGTR1
5primary non-gestational choriocarcinoma of ovary10.6ACE, TGFB1
6coxa vara, congenital10.6ACE, AGTR1
7ischemic optic neuropathy10.6ACE, AGTR1
8voyeurism10.6ACE, AGTR1
9renal tubular dysgenesis10.5ACE, AGTR1
10endogenous depression10.5ACE, AGTR1
11glomus tympanicum tumor10.5ACE, CCL2
12meningococcemia10.4ADRB1, AGTR1
13fibrosing mediastinitis10.4ACE, AGTR1, TGFB1
14posterior valve urethra10.4ACE, AGTR1, TGFB1
15idiopathic hypersomnia10.4ACE, NR3C2
16acute myeloblastic leukemia with maturation10.4ACE, AGTR1
17antiphospholipid syndrome10.4ACE, AGTR1, TGFB1
18non-congenital cyst of kidney10.3ACE, AGTR1, TGFB1
19epidermolysis bullosa dystrophica10.3ACE, AGTR1, TGFB1
20crescentic glomerulonephritis10.3CCL2, SYNPO
21malignant acrospiroma10.3ACE, TGFB1, UBD
22oral mucosa leukoplakia10.3ACE, NR3C2
23episodic ataxia10.3CTGF, TGFB1
24laryngeal tuberculosis10.3CTGF, TGFB1
25pulmonary hypertension10.3CCL2, TGFB1
26aortic dissection lentiginosis10.3ACE, ADRB1, AGTR1
27cerebral lipidosis10.3ACE, ADRB1, AGTR1
28signet ring cell variant cervical mucinous adenocarcinoma10.3ACE, AGTR1
29whipple disease10.2CTGF, TGFB1
30craniorachischisis10.2ACE, ADRB1, AGTR1
31abnormal pupillary function10.2ACE, AGTR1, NR3C2
32familial hyperthyroidism due to mutations in tsh receptor10.2AGTR1, NR3C2
33multilocular clear cell renal cell carcinoma10.2ACE, AGTR1, NR3C2
34chronic venous insufficiency10.2ACE, AGTR1, CCL2
35sympathetic ophthalmia10.2AGTR1, NR3C2
36ophthalmia nodosa10.1CTGF, TGFB1
37mitochondrial metabolism disease10.1ACE, CCL2, TGFB1
38cystic echinococcosis10.1CTGF, TGFB1
39oral squamous cell carcinoma10.1ACE, MTHFR
40senile atrophy of choroid10.1ACE, AGTR1, CTGF
41glomerulonephritis10.1
42kidney disease10.1
43citrullinemia, adult-onset type ii10.1ACE, AGTR1, CTGF
44pyrimidine metabolic disorder10.1ACE, CCL2
45temporal lobe epilepsy10.0ACE, CTGF, TGFB1
46colonic pseudo-obstruction10.0MTHFR, TGFB1
47hemolytic-uremic syndrome10.0
48focal embolic glomerulonephritis10.0CCL2, CTGF
49fetal erythroblastosis10.0ACE, AGTR1, SYNPO, TGFB1
50malignant hypertension10.0

Comorbidity relations with Nephrosclerosis via Phenotypic Disease Network (PDN):


Acute Kidney FailureChronic Kidney Failure
Deficiency AnemiaHeart Disease
Hypertension, EssentialIschemic Heart Disease
Acute CystitisHydronephrosis
NephrolithiasisPrimary Hyperoxaluria

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to nephrosclerosis

Symptoms for Nephrosclerosis

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Drugs & Therapeutics for Nephrosclerosis

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Drugs for Nephrosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Valsartanapproved, investigationalPhase 4268137862-53-460846
Synonyms:
(2S)-3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid
(S)-N-Valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine
(S)-N-valeryl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl}-valine
(s)-2-(n-((2'-(1h-tetrazol-5-yl)biphenyl-4-yl)methyl)pentanamido)-3-methylbutanoic acid
137862-53-4
AC-4543
AC1L1U1M
AC1Q5QIK
Ambap137862-53-4
Aventis brand of valsartan
BIDD:GT0345
BRD-K45158365-001-02-3
BSPBio_003501
Bio-0796
C081489
C24H29N5O3
CEPA brand of valsartan
CGP 48933
CGP-48933
CHEBI:9927
CHEMBL1069
CID60846
CPD000466318
D00400
DB00177
Diovan
Diovan (TN)
Diovan, Valsartan
Esteve brand of valsartan
HMS1922L21
HMS2051L12
HMS2093K22
HSDB 7519
KBio2_002287
KBio2_004855
KBio2_007423
KBio3_003006
KBioGR_001078
KBioSS_002289
Kalpress
 
L-Valine, N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (9CI)
LS-161334
Lacer brand of valsartan
MLS000759423
MLS001424088
Miten
MolPort-002-507-854
MolPort-003-666-608
N-(1-oxopentyl)-N-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-L-valine
N-(P-(O-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine
N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine
N-Pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine
N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-L-valine
N-pentanoyl-N-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-L-valine
N-valeryl-N-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)valine
Nisis
Nisis||
Novartis brand of valsartan
Provas
S1894_Selleck
SAM001246581
SMR000466318
SPBio_001260
SPECTRUM1505209
Sanol brand of valsartan
Schwarz brand of valsartan
Spectrum2_001120
Spectrum3_001831
Spectrum4_000749
Spectrum5_001582
Spectrum_001796
TL8000869
Tareg
UNII-80M03YXJ7I
Vals
Valsarran
Valsartan
Valsartan (JAN/USAN/INN)
Valsartan [USAN:INN]
valsartan
walsartan
|Tareg
2
Angiotensin IIPhase 4103368521-88-0, 11128-99-7172198, 65143
Synonyms:
1-8-Angiotensin I
1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide
Ang II
Angiotensin 2
Angiotensin II (human)
 
Angiotensin II (mouse)
Angiotonin
Asp-arg-val-TYR-ile-his-pro-phe
Human angiotensin II
Hypertensin
Ile(5)-angiotensin II
3AngiotensinogenPhase 41032
4Antihypertensive AgentsPhase 43618
5Angiotensin II Type 1 Receptor BlockersPhase 4949
6Angiotensin Receptor AntagonistsPhase 41039
7BeraprostinvestigationalPhase 2, Phase 31488430-50-66917950
8Vasodilator AgentsPhase 2, Phase 32926
9TezosentanPhase 2, Phase 364
10Platelet Aggregation InhibitorsPhase 2, Phase 31935

Interventional clinical trials:

idNameStatusNCT IDPhase
1Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney DiseaseTerminatedNCT01129557Phase 4
2TRK-100STP Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis)CompletedNCT01090037Phase 2, Phase 3
3TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis)CompletedNCT02480751Phase 2
4Renal NCE-MRI in Healthy VolunteersCompletedNCT02618460

Search NIH Clinical Center for Nephrosclerosis


Cochrane evidence based reviews: nephrosclerosis

Genetic Tests for Nephrosclerosis

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Anatomical Context for Nephrosclerosis

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MalaCards organs/tissues related to Nephrosclerosis:

33
Kidney, Prostate, Pituitary, Thyroid, Breast, Ovary, Bone

Animal Models for Nephrosclerosis or affiliated genes

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MGI Mouse Phenotypes related to Nephrosclerosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.1ACE, AGTR1, BMP5, NR3C2, SYNPO, TGFB1
2MP:00053857.4ACE, ADRB1, AGTR1, BMP5, CTGF, NR3C2
3MP:00053786.5ACE, ADRB1, AGTR1, BMP5, CTGF, MTHFR

Publications for Nephrosclerosis

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Articles related to Nephrosclerosis:

(show top 50)    (show all 267)
idTitleAuthorsYear
1
Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis. (23151750)
2013
2
Castleman's disease accompanied by hypolipidemic cerebral hemorrhage and nephrosclerosis. (23857095)
2013
3
Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis. (22236281)
2012
4
The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. (21319131)
2011
5
Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. (21080950)
2010
6
The association between age and nephrosclerosis on renal biopsy among healthy adults. (20439574)
2010
7
Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. (19745105)
2009
8
Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease in TGF-beta(1). (17998773)
2007
9
Hypertensive nephrosclerosis. (16988752)
2006
10
Dr. Yang Nizhi's experience in treating benign arteriolar nephrosclerosis. (16705856)
2006
11
Hypertensive nephrosclerosis: update. (15202608)
2004
12
Stent angioplasty of severe atherosclerotic ostial renal artery stenosis in patients with diabetes mellitus and nephrosclerosis. (12652503)
2003
13
Hypertensive nephrosclerosis in African Americans versus Caucasians. (12081576)
2002
14
Nipradilol prevents L-NAME-exacerbated nephrosclerosis with decreasing of caspase-3 expression in SHR. (12135323)
2002
15
A 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor reduces hypertensive nephrosclerosis in stroke-prone spontaneously hypertensive rats. (12473872)
2002
16
Cytochrome c mediates apoptosis in hypertensive nephrosclerosis in Dahl/Rapp rats. (11168948)
2001
17
Intrauterine food restriction as a determinant of nephrosclerosis. (11228169)
2001
18
Cilnidipine is as effective as benazepril for control of blood pressure and proteinuria in hypertensive patients with benign nephrosclerosis. (11510750)
2001
19
Hypertensive nephrosclerosis pathogenesis, diagnosis and management. (18212435)
1999
20
The clinical diagnosis of hypertensive nephrosclerosis--how reliable is it? (10069175)
1999
21
Accuracy of the diagnosis of hypertensive nephrosclerosis in African Americans: a report from the African American Study of Kidney Disease (AASK) Trial. AASK Pilot Study Investigators. (8995739)
1997
22
Hydrochlorothiazide exacerbates nitric oxide-blockade nephrosclerosis with glomerular hypertension in spontaneously hypertensive rats. (8818920)
1996
23
Immunohistochemical analysis of type III and IV collagens in tubulointerstitial damage in human benign nephrosclerosis. (8746616)
1995
24
Effects of novel, nonpeptide vasopressin antagonists on progressive nephrosclerosis in rats. (7630164)
1995
25
Hypertensive nephrosclerosis in the Dahl/Rapp rat. Initial sites of injury and effect of dietary L-arginine supplementation. (8441251)
1993
26
Clinical features of benign hypertensive nephrosclerosis at time of renal biopsy. (8327642)
1993
27
Cholinergic vasodilatory effect of an imidazoindole on the nephrosclerosis of hypertensive rats. (2383253)
1990
28
Decompensated benign nephrosclerosis and secondary malignant nephrosclerosis. (3720032)
1986
29
Quantitation of hypertensive nephrosclerosis on an objective rational scale of measure in adults and children. (3751980)
1986
30
Proteinuria in benign nephrosclerosis. (3729631)
1986
31
Marked proteinuria in hypertensive nephrosclerosis. (3160240)
1985
32
Glomerular injury in malignant nephrosclerosis. (740104)
1978
33
Pathology of malignant nephrosclerosis with special reference to the difference between histologic manifestations of pure and exacerbated forms. (694919)
1978
34
Nephrosclerosis postpartum and in women taking oral contraceptives. (1247349)
1976
35
Asymmetrical interlobar nephrosclerosis. (4131975)
1974
36
Bilateral nephrectomy and renal homotransplantation for malignant nephrosclerosis. (4576897)
1973
37
The role of nephrosclerosis in separate function tests. (5444314)
1970
38
RHEUMATIC NEPHROSCLEROSIS WITH SPECIAL REFERENCE TO RHEUMATIC ENDARTERITIS. (14297514)
1965
39
IMMUNOCYTOCHEMICAL OBSERVATIONS ON THE VASCULAR NECROSIS AND RENAL GLOMERULAR LESIONS OF MALIGNANT NEPHROSCLEROSIS. (14328020)
1965
40
MALIGNANT HYPERTENSION, MALIGNANT NEPHROSCLEROSIS, AND SYSTEMIC VASCULITIS. (14303079)
1965
41
Radiation nephrosclerosis. (13725173)
1960
42
The hormonal production of nephrosclerosis and periarteritis nodosa in the primate. (13383223)
1957
43
CLINICO-PATHOLOGICAL conference: large fibromyomata uteri with hypertensive heart disease and arteriolar nephrosclerosis. (13086088)
1953
44
Uremia and disseminated platelet-cell (thrombocyte) thrombosis; report of a case due to malignant nephrosclerosis with acute pancreatitis. (14914218)
1952
45
Malignant nephrosclerosis without retinal edema in a child; long-term observations and renal function studies. (14902103)
1952
46
VA clinical pathological conference: cerebral hemorrhage associated with malignant nephrosclerosis and cardiac hypertrophy. (13013101)
1952
47
Unilateral renal cortical necrosis and unilateral benign and malignant nephrosclerosis, associated with contralateral renal artery occlusion: report of a case. (14789332)
1951
48
Nephrosclerosis]. (20271308)
1947
49
Nephrosclerosis, benign and malignant. (20293863)
1947
50
Benign and Malignant Hypertension and Nephrosclerosis: A Clinical and Pathological Study. (19970253)
1936

Variations for Nephrosclerosis

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Expression for genes affiliated with Nephrosclerosis

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Search GEO for disease gene expression data for Nephrosclerosis.

Pathways for genes affiliated with Nephrosclerosis

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GO Terms for genes affiliated with Nephrosclerosis

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Biological processes related to Nephrosclerosis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:003294310.5ACE, TGFB1
2positive regulation of cellular protein metabolic processGO:003227010.3AGTR1, TGFB1
3positive regulation of collagen biosynthetic processGO:003296710.2CCL2, TGFB1
4cellular response to organic cyclic compoundGO:007140710.1CCL2, TGFB1
5organ regenerationGO:003110010.1CCL2, TGFB1
6SMAD protein signal transductionGO:006039510.0BMP5, TGFB1
7response to progesteroneGO:003257010.0CCL2, TGFB1
8positive regulation of pathway-restricted SMAD protein phosphorylationGO:001086210.0BMP5, TGFB1
9growthGO:004000710.0BMP5, TGFB1
10myeloid dendritic cell differentiationGO:004301110.0TGFB1, UBD
11regulation of vasoconstrictionGO:00192299.9ACE, AGTR1
12lipopolysaccharide-mediated signaling pathwayGO:00316639.8CCL2, TGFB1
13response to woundingGO:00096119.4CCL2, CTGF, TGFB1
14cellular response to dexamethasone stimulusGO:00715499.4CCL2, TGFB1
15response to drugGO:00424939.0CCL2, MTHFR, TGFB1

Sources for Nephrosclerosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet