MCID: NPH010
MIFTS: 53

Nephrosclerosis malady

Nephrological category

Summaries for Nephrosclerosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Hypertensive nephropathy (or \"hypertensive nephrosclerosis\", or \"Hypertensive renal disease\") is a... more...

MalaCards: Nephrosclerosis, also known as renal sclerosis, unspecified, is related to hemolytic-uremic syndrome and arteriosclerosis. An important gene associated with Nephrosclerosis is ADM (adrenomedullin), and among its related pathways are Renin-angiotensin system and Calcitonin-like ligand receptors. The compounds pge2 and estrogen have been mentioned in the context of this disorder. Affiliated tissues include kidney, spleen and heart, and related mouse phenotypes are endocrine/exocrine gland and muscle.

Aliases & Classifications for Nephrosclerosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Aliases & Descriptions:

nephrosclerosis 8 43 45 61
renal sclerosis, unspecified 8
renal sclerosis unspecified 8
renal sclerosis nos 8
renal sclerosis 8


External Ids:

Disease Ontology8 DOID:11664
ICD9CM27 587
MeSH35 D009400

Related Diseases for Nephrosclerosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 168)
idRelated DiseaseScoreTop Affiliating Genes
1hemolytic-uremic syndrome30.4ADAMTS13
2arteriosclerosis30.2ADM
3uremia30.2ALAD, LPA, LCAT
4hypertensive heart disease30.1ACE, NR3C2, AGTR1
5atherosclerosis30.1LCAT, CTGF, LPA, MPO, NR3C2, AGTR1
6acute pancreatitis29.9MPO
7renovascular hypertension29.9AGTR1, ACE, ADM
8nephritis29.9ACE, CTGF, MPO
9insulin resistance29.9ACE, LCAT, CTGF, NR3C2, LPA, AGTR1
10vascular disease29.8ACE, AGTR1, NR3C2, CTGF, LCAT, LPA
11coronary heart disease29.8ADRB1, ADAMTS13, SERPINC1, ACE, THBS1, AGTR1
12n syndrome10.4
13periarteritis nodosa10.2
14focal glomerulosclerosis10.1
15tuberculosis10.1
16lung cancer10.0TGFB1
17cor pulmonale10.0AGTR1
18pulmonary disease, chronic obstructive10.0TGFB1
19multiple sclerosis10.0TGFB1
20anuria10.0ACE
21chagas disease10.0ADRB1
22primary pulmonary hypertension10.0ADM
23polycystic ovary syndrome10.0NR3C2
24vesicoureteral reflux10.0AGTR1
25severe acute respiratory syndrome10.0ACE2
26cholestasis10.0LCAT
27hypothyroidism10.0LPA
28oligohydramnios10.0ACE
29myocarditis10.0ADRB1
30intracranial aneurysm10.0ACE2
31myelofibrosis10.0TGFB1
32urticaria10.0ACE
33lupus erythematosus10.0SERPINC1
34cystic fibrosis10.0MPO
35acromegaly10.0LPA
36gout10.0LCAT
37eclampsia10.0SERPINC1
38thyroiditis10.0CALCA
39thromboembolism10.0SERPINC1
40otosclerosis10.0TGFB1
41mitral valve prolapse10.0AGTR1
42amyloidosis10.0LPA
43meningioma10.0ALAD
44hyperthyroidism10.0ADM
45pulmonary embolism10.0SERPINC1
46kawasaki disease10.0ADM
47lupus nephritis10.0ADAMTS13, TGFB1
48malaria10.0ALAD, ADAMTS13
49angioedema10.0ACE
50migraine10.0CALCA

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to nephrosclerosis

Clinical Features for Nephrosclerosis

Drugs & Therapeutics for Nephrosclerosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Nephrosclerosis

Drug clinical trials:

Search ClinicalTrials for Nephrosclerosis

Search NIH Clinical Center for Nephrosclerosis

Search CenterWatch for Nephrosclerosis

Genetic Tests for Nephrosclerosis

Anatomical Context for Nephrosclerosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Nephrosclerosis:

33
Kidney, Spleen, Heart, Smooth muscle, Pancreas, Adrenal gland, Endothelial, Pituitary

Animal Models for Nephrosclerosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Nephrosclerosis

Sources:
51PubMed
See all sources

Articles related to Nephrosclerosis:

(show top 50)    (show all 254)
idTitleAuthorsYear
1
Hypertension, glomerular hypertrophy and nephrosclerosis: the effect of race. (24327566)
2013
2
Subclinical nephrosclerosis is linked to left ventricular hypertrophy independent of classical atherogenic factors. (24305517)
2013
3
Endothelial Sirtuin 1 Deficiency Perpetrates Nephrosclerosis through Downregulation of Matrix Metalloproteinase-14: Relevance to Fibrosis of Vascular Senescence. (24136919)
2013
4
Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis. (22236281)
2012
5
Involvement of connective tissue growth factor in human and experimental hypertensive nephrosclerosis. (20689330)
2011
6
Human nephrosclerosis triggers a hypoxia-related glomerulopathy. (20019191)
2010
7
Intrarenal expression of miRNAs in patients with hypertensive nephrosclerosis. (19910931)
2010
8
Relationship between body mass index and proteinuria in hypertensive nephrosclerosis: results from the African American Study of Kidney Disease and Hypertension (AASK) cohort. (20801567)
2010
9
(Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. (18212268)
2008
10
Effects of renin-angiotensin system blockade on macrophage infiltration in patients with hypertensive nephrosclerosis. (17785932)
2007
11
ACE inhibition is effective and renoprotective in hypertensive nephrosclerosis: the African American Study of Kidney Disease and Hypertension (AASK) trial. (12864879)
2003
12
Hypertensive nephrosclerosis in African Americans. (14633170)
2003
13
Nipradilol prevents L-NAME-exacerbated nephrosclerosis with decreasing of caspase-3 expression in SHR. (12135323)
2002
14
Cilnidipine is as effective as benazepril for control of blood pressure and proteinuria in hypertensive patients with benign nephrosclerosis. (11510750)
2001
15
Clinical trials report. The effect of Ramipril versus Amlodipine on renal outcomes in hypertension nephrosclerosis. (11551370)
2001
16
ACE inhibitors and appearance of renal events in hypertensive nephrosclerosis. (11566948)
2001
17
Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trial. (11386927)
2001
18
Hypertensive nephrosclerosis pathogenesis, diagnosis and management. (18212435)
1999
19
Progression of renal failure and hypertensive nephrosclerosis. (9839285)
1998
20
Antihypertensive agents prevent nephrosclerosis and left ventricular hypertrophy induced in rats by prolonged inhibition of nitric oxide synthesis. (9657629)
1998
21
ET(A) receptor antagonist ameliorates nephrosclerosis and left ventricular hypertrophy induced in rat by prolonged inhibition of nitric oxide synthesis. (9877518)
1998
22
Accuracy of the diagnosis of hypertensive nephrosclerosis in African Americans: a report from the African American Study of Kidney Disease (AASK) Trial. AASK Pilot Study Investigators. (8995739)
1997
23
Effect of 2,3-dimercaptosuccinic acid on nephrosclerosis in the Dahl rat. I. Role of reactive oxygen species. (8914024)
1996
24
Renal vascular lesions in the elderly: nephrosclerosis or atheromatous renal disease? (9050035)
1996
25
Glomerular expression of type III and type IV collagens in benign nephrosclerosis: immunohistochemical and in situ hybridization study. (7991469)
1994
26
Clinical features of benign hypertensive nephrosclerosis at time of renal biopsy. (8327642)
1993
27
Blood pressure and nephrosclerosis in black and white men and women aged 25 to 54. (1758872)
1991
28
Two variants of nephrosclerosis separately related to age and blood pressure. (3358455)
1988
29
Proteinuria in benign nephrosclerosis. (3729631)
1986
30
Cellular arteriolar nodules. Their presence in heart, pancreas, and kidneys of patients with malignant nephrosclerosis. (6895829)
1982
31
Single-nephron pressures, flows, and resistances in hypertensive kidneys with nephrosclerosis. (894914)
1977
32
Malignant nephrosclerosis during pregnancy and in the postpartum period (the uremic hemolytic syndrome). (779474)
1976
33
Nephrosclerosis and blood pressure. I. Rising and falling patterns in lengthy records. (4812805)
1974
34
Effect of bilateral nephrectomy in postpartum nephrosclerosis. (5093216)
1971
35
Malignant nephrosclerosis--50 years later. (5327181)
1966
36
RHEUMATIC NEPHROSCLEROSIS WITH SPECIAL REFERENCE TO RHEUMATIC ENDARTERITIS. (14297514)
1965
37
Juxtaglomerular cells, renal pressor substances and nephrosclerosis. (14470951)
1962
38
Unilateral malignant nephrosclerosis with superimposed unilateral cortical necrosis following aortogram. (13682150)
1961
39
Radiation nephrosclerosis. (13725173)
1960
40
Effects of antihypertensive treatment on the evolution of the renal lesions in malignant nephrosclerosis. (13583093)
1958
41
Malignant nephrosclerosis with verrucal angionecrosis; report of 2 cases. (13362159)
1956
42
WEEKLY clinicopathological exercises: right subdural hematoma with chronic pyelonephritis and nephrosclerosis. (13063704)
1953
43
Nephrosclerosis and the glomerulus. (13065412)
1953
44
The production of hypertension, nephrosclerosis and cardiac lesions by methylandrostenediol treatment in the rat. (13107625)
1953
45
Influence of amino-acids on adrenal enlargement, nephrosclerosis and hypertension by anterior pituitary preparations. (18106693)
1948
46
Nephrosclerosis, benign and malignant. (20293863)
1947
47
Further studies concerning the role of the diet in the production of nephrosclerosis and hypertension by anterior pituitary preparations. (20342819)
1947
48
The role of the adrenals in the production of nephrosclerosis by anterior pituitary preparations. (20988407)
1946
49
Production of Nephrosclerosis by Overdosage with Desoxycorticosterone Acetate. (20322632)
1942
50
Benign and Malignant Hypertension and Nephrosclerosis: A Clinical and Pathological Study. (19970253)
1936

Genetic Variations for Nephrosclerosis

Expression for genes affiliated with Nephrosclerosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Nephrosclerosis

Search GEO for disease gene expression data for Nephrosclerosis.

Pathways for genes affiliated with Nephrosclerosis

Sources:
30KEGG, 54Reactome, 56SinoBiological, 50PharmGKB, 38NCBI BioSystems Database, 52QIAGEN
See all sources

Compounds for genes affiliated with Nephrosclerosis

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Nephrosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 144)
idCompoundScoreTop Affiliating Genes
1pge24510.7TGFB1
2estrogen4510.5LPA, LCAT
3benazepril45 1111.4AGTR1, TGFB1, ACE
4procollagen4510.4TGFB1
5angiotensin ii29 2411.3ACE2, ACE, AGTR1
6carvedilol45 50 29 1113.3ADRB1, ADM, ACE, AGTR1
7aldosterone29 11 2412.3ADM, AGTR1, CTGF, NR3C2
8clonidine45 29 1112.3CALCA, ADRB1, AGTR1
9eplerenone45 60 29 1113.3NR3C2, AGTR1, ACE, ACE2
10thiazide4510.2CALCA, ACE, AGTR1, NR3C2
11ramipril45 1111.2TGFB1, ACE, AGTR1, ACE2
12superoxide45 2411.2LPA, NR3C2, ALAD, AGTR1
13nitroglycerin45 1111.2AGTR1, ACE, CALCA, ADM
14lisinopril45 11 2412.2AGTR1, ACE2, ACE
15norepinephrine45 11 2412.2CALCA, NR3C2, ADRB1, ADM
16amiloride45 29 1112.1TGFB1, NR3C2, MPO, CTGF
17methacholine45 1111.1TGFB1, AGTR1, MPO, CALCA
18ang ii4510.1ADM, CTGF, AGTR1, ACE, TGFB1, NR3C2
19losartan45 50 29 1113.0NR3C2, CTGF, AGTR1, ADM, TGFB1, ACE
20vitamin d4510.0AGTR1, NR3C2, CALCA, THBS1, ALAD
21malondialdehyde4510.0ALAD, ADM, LPA, MPO
22thiorphan45 29 1112.0ADM, ACE, CALCA
23captopril45 29 50 60 1114.0ADM, ACE2, CTGF, NR3C2, CALCA
24tgf beta14510.0TGFB1, THBS1, CTGF, BMP7, AGTR1
25kininogen4510.0SERPINC1, ACE, THBS1, MPO
26potassium45 11 2411.9ALAD, ACE, AGTR1, NR3C2, ADM, ADRB1
27dexamethasone45 50 29 1112.9BMP7, TGFB1, LCAT, NR3C2, ADRB1, CTGF
28propranolol45 29 50 11 2413.9CALCA, MPO, ADRB1, ADM
29prostacyclin459.9ACE, ADM, SERPINC1, CTGF, AGTR1, THBS1
30acth459.9ADM, LPA, NR3C2, AGTR1, CALCA
31cyclosporin a45 29 6011.8CALCA, ADM, ADAMTS13, CTGF, THBS1, NR3C2
32oxygen45 2410.8BMP7, MPO, NR3C2, ACE2, ADRB1, ADM
33atenolol45 29 50 11 2413.8AGTR1, ACE, ADRB1
34heparin45 29 11 2412.8LCAT, CTGF, BMP7, MPO, ADAMTS13, LPA
35aspirin45 50 29 2412.7AGTR1, TGFB1, SERPINC1, ACE, LPA
36fibrinogen459.7LPA, AGTR1, THBS1, CTGF, ADAMTS13, SERPINC1
37pravastatin45 50 29 11 2413.7CTGF, LCAT, AGTR1, LPA
38chloride459.7NR3C2, LPA, MPO, ADAMTS13, ACE2
39creatinine459.6ADAMTS13, ACE, BMP7, LPA, SYNPO, TGFB1
40alanine459.6NR3C2, AGTR1, ADM, LCAT, TGFB1, ADRB1
41cholesterol45 29 11 2412.5ADM, ACE2, AGTR1, NR3C2, THBS1, LPA
42testosterone45 60 11 2412.5CALCA, NR3C2, THBS1, ADM, ALAD, LCAT
43glucose459.4CTGF, ADRB1, ACE, AGTR1, NR3C2, LPA
44lactate459.4ALAD, TGFB1, ADM, CALCA, MPO, CTGF
45retinoic acid45 2410.4BMP7, MPO, NR3C2, ADRB1, THBS1, TGFB1
46lipid459.2LCAT, BMP7, LPA, THBS1, CTGF, ACE
47serine459.2LCAT, CTGF, BMP7, THBS1, NR3C2, TGFB1
48vegf459.0LPA, BMP7, CTGF, CALCA, AGTR1, THBS1
49nitric oxide45 11 2410.8ALAD, NR3C2, AGTR1, THBS1, ACE, MPO
50calcium45 50 11 2411.8CALCA, MPO, ADRB1, ADAMTS13, ALAD, ACE

GO Terms for genes affiliated with Nephrosclerosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Nephrosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4CALCA, CTGF, BMP7, LPA, THBS1, ACE
2extracellular spaceGO:0056157.7TGFB1, LCAT, CALCA, CTGF, BMP7, BMP5

Biological processes related to Nephrosclerosis according to GeneCards/GeneDecks:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1mononuclear cell proliferationGO:03294310.5TGFB1, ACE
2peptide catabolic processGO:04317110.5ADAMTS13, ACE
3angiotensin catabolic process in bloodGO:00200510.4ACE2, ACE
4positive regulation of fibroblast migrationGO:01076310.4TGFB1, THBS1
5negative regulation of smooth muscle contractionGO:04598610.4ADRB1, CALCA
6positive regulation of chemotaxisGO:05092110.3THBS1, TGFB1
7regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.3ACE2, ACE, AGTR1
8regulation of vasodilationGO:04231210.3ACE2, ACE, AGTR1
9positive regulation of dendrite developmentGO:190000610.3BMP7, BMP5
10regulation of vasoconstrictionGO:01922910.3AGTR1, ACE, ACE2
11positive regulation of pathway-restricted SMAD protein phosphorylationGO:01086210.3TGFB1, BMP5, BMP7
12positive regulation of cellular protein metabolic processGO:03227010.3AGTR1, TGFB1
13response to woundingGO:00961110.3CTGF, ADM, TGFB1
14positive regulation of cAMP biosynthetic processGO:03081910.3ADM, ADRB1, CALCA
15G-protein coupled receptor internalizationGO:00203110.3ADM, CALCA
16low-density lipoprotein particle remodelingGO:03437410.3AGTR1, MPO
17positive regulation of reactive oxygen species metabolic processGO:200037910.3AGTR1, THBS1, ACE2
18response to glucose stimulusGO:00974910.2TGFB1, THBS1, CTGF
19agingGO:00756810.2TGFB1, ADM, ADRB1, CALCA
20regulation of inflammatory responseGO:05072710.2CALCA, AGTR1, ACE2
21angiotensin maturationGO:00200310.2ACE, ACE2
22ossificationGO:00150310.1BMP5, BMP7, CTGF
23negative regulation of blood vessel endothelial cell migrationGO:04353710.1THBS1, TGFB1
24elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.1AGTR1, CALCA
25positive regulation of peptidyl-threonine phosphorylationGO:01080010.1BMP7, TGFB1
26proteolysisGO:0065089.8UBD, LPA, ACE, ACE2, ADAMTS13
27elevation of cytosolic calcium ion concentrationGO:0072049.7ADM, AGTR1, CALCA

Molecular functions related to Nephrosclerosis according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:03171110.3ACE, AGTR1
2peptidyl-dipeptidase activityGO:00824110.1ACE, ACE2
3fibronectin bindingGO:00196810.0THBS1, LPA, CTGF
4integrin bindingGO:0051789.9ADAMTS13, THBS1, CTGF
5growth factor activityGO:0080839.7TGFB1, BMP5, BMP7, CTGF
6metallopeptidase activityGO:0082379.6ACE, ACE2, ADAMTS13
7heparin bindingGO:0082019.6SERPINC1, THBS1, MPO, LPA, CTGF
8protein bindingGO:0055158.1SYNPO, BMP7, CTGF, UBD, CALCA, LCAT

Products for genes affiliated with Nephrosclerosis

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Sources for Nephrosclerosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet