MCID: NPH010
MIFTS: 43

Nephrosclerosis malady

Categories: Rare diseases, Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Nephrosclerosis

Aliases & Descriptions for Nephrosclerosis:

Name: Nephrosclerosis 12 50 29 52 42 14 69
Renal Sclerosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11664
ICD10 33 I12 N26.9
ICD9CM 35 587
MeSH 42 D009400
UMLS 69 C0027719

Summaries for Nephrosclerosis

MalaCards based summary : Nephrosclerosis, also known as renal sclerosis, is related to idiopathic panuveitis and iris disease. An important gene associated with Nephrosclerosis is ACE (Angiotensin I Converting Enzyme), and among its related pathways/superpathways are p70S6K Signaling and Dilated cardiomyopathy. The drugs Valsartan and Antihypertensive Agents have been mentioned in the context of this disorder. Affiliated tissues include kidney, pituitary and heart, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Nephrosclerosis

Diseases related to Nephrosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
id Related Disease Score Top Affiliating Genes
1 idiopathic panuveitis 10.2 ACE TGFB1
2 iris disease 10.2 ACE AGTR1
3 preaxial polydactyly of fingers 10.2 ACE AGTR1 TGFB1
4 flat umbilicus familial 10.2 ACE AGTR1 TGFB1
5 systolic heart failure 10.2 ACE AGTR1 TGFB1
6 ulnar hemimelia 10.2 CTGF SYNPO
7 miliaria 10.1 CTGF TGFB1
8 aplasia cutis congenita recessive 10.1 ACE ADRB1 AGTR1
9 skin conditions 10.1 ACE CCL2 TGFB1
10 kartagener syndrome 10.1 ACE MTHFR
11 prostate neuroendocrine neoplasm 10.1 ACE AGTR1 NR3C2
12 eye degenerative disease 10.1 ACE AGTR1 CTGF
13 geleophysic dysplasia 2 10.1 CTGF TGFB1
14 laryngostenosis 10.1 ACE AGTR1 NR3C2
15 acute chest syndrome 10.1 ACE CCL2 TGFB1
16 pars planitis 10.1 ACE MTHFR
17 clear cell adenocarcinoma 10.1 ACE AGTR1 NR3C2
18 anhidrosis 10.1 CTGF TGFB1
19 testicular lymphoma 10.1 ACE CTGF TGFB1
20 alpha-2-plasmin inhibitor deficiency 10.1 ACE AGTR1 MTHFR
21 pauci-immune glomerulonephritis 10.0 NPHS1 NPHS2
22 toxic myocarditis 10.0 ACE ADRB1 NR3C2
23 detrusor sphincter dyssynergia 10.0 ADRB1 CCL2 TGFB1
24 albinism, oculocutaneous, type ia 10.0 CCL2 CTGF TGFB1
25 acute necrotizing encephalitis 10.0 CCL2 CTGF TGFB1
26 cascade stomach 10.0 ACE AGTR1
27 cervix small cell carcinoma 10.0 ACE AGTR1 MTHFR
28 malignant neoplasm of acoustic nerve 10.0 CCL2 CTGF TGFB1
29 sick sinus syndrome 3 10.0 NPHS1 NPHS2
30 benign secondary hypertension 10.0 CCL2 NPHS2 SYNPO TGFB1
31 renal tubular acidosis 10.0 CCL2 CTGF TGFB1
32 bullous skin disease 10.0 ACE MTHFR
33 glomerulonephritis 10.0
34 glaucoma 1, open angle, e 10.0 NPHS1 NPHS2
35 vernal conjunctivitis 10.0 ACE CTGF MTHFR
36 diprosopia 10.0 NPHS1 NPHS2 TGFB1
37 pulmonary valve insufficiency 10.0 ACE CCL2 CTGF TGFB1
38 kidney disease 9.9
39 hypothyroidism, congenital, nongoitrous, 3 9.9 NPHS1 NPHS2 SYNPO
40 critical limb ischemia 9.9 ACE ADRB1 AGTR1 NR3C2
41 congenital torticollis 9.9 NPHS1 NPHS2
42 gastric cancer 9.9 NPHS1 NPHS2 SYNPO
43 hypertension, essential 9.9 ACE ADRB1 AGTR1 NR3C2
44 focal segmental glomerulosclerosis 9.9 NPHS1 NPHS2
45 budd-chiari syndrome 9.9 ACE AGTR1 MTHFR
46 hemolytic-uremic syndrome 9.9
47 pyrimidine metabolic disorder 9.9 ACE AGTR1 CCL2 MTHFR
48 macular degeneration, age-related, 12 9.9 ACE ADRB1 AGTR1 MTHFR
49 biliary cirrhosis, primary, 2 9.9 ACE NPHS1 NPHS2 TGFB1
50 malignant hyperthermia susceptibility 1 9.9 ACE NPHS1 NPHS2 SYNPO

Comorbidity relations with Nephrosclerosis via Phenotypic Disease Network (PDN):


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Heart Disease Hydronephrosis
Hypertension, Essential Ischemic Heart Disease
Kidney Disease Nephrolithiasis, Type I

Graphical network of the top 20 diseases related to Nephrosclerosis:



Diseases related to Nephrosclerosis

Symptoms & Phenotypes for Nephrosclerosis

MGI Mouse Phenotypes related to Nephrosclerosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 BMP5 CTGF NPHS2 NR3C2 TGFB1 ACE
2 growth/size/body region MP:0005378 9.91 ACE ADRB1 AGTR1 BMP5 CTGF MTHFR
3 homeostasis/metabolism MP:0005376 9.81 NPHS1 NPHS2 NR3C2 TGFB1 ACE ADRB1
4 mortality/aging MP:0010768 9.65 ACE ADRB1 AGTR1 BMP5 CTGF MTHFR
5 renal/urinary system MP:0005367 9.23 ACE AGTR1 BMP5 NPHS1 NPHS2 NR3C2

Drugs & Therapeutics for Nephrosclerosis

Drugs for Nephrosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
2 Antihypertensive Agents Phase 4,Phase 2,Phase 3
3
Angiotensin II Phase 4 68521-88-0, 11128-99-7 65143 172198
4 Angiotensin II Type 1 Receptor Blockers Phase 4
5 Angiotensin Receptor Antagonists Phase 4
6 Angiotensinogen Phase 4
7
Epoprostenol Approved Phase 2, Phase 3 61849-14-7, 35121-78-9 5280427 5282411
8 Beraprost Investigational Phase 2, Phase 3 88430-50-6
9 Platelet Aggregation Inhibitors Phase 2, Phase 3
10 Tezosentan Phase 2, Phase 3
11 Vasodilator Agents Phase 2, Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 Aldosterone Breakthrough During Diovan, Tekturna, and Combination Therapy in Patients With Proteinuric Kidney Disease Terminated NCT01129557 Phase 4
2 TRK-100STP Clinical Study - Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT01090037 Phase 2, Phase 3
3 TRK-100STP PhaseII Clinical Study -Chronic Renal Failure (Primary Glomerular Disease/Nephrosclerosis) Completed NCT02480751 Phase 2
4 Renal NCE-MRI in Healthy Volunteers Completed NCT02618460

Search NIH Clinical Center for Nephrosclerosis

Cochrane evidence based reviews: nephrosclerosis

Genetic Tests for Nephrosclerosis

Genetic tests related to Nephrosclerosis:

id Genetic test Affiliating Genes
1 Nephrosclerosis 29

Anatomical Context for Nephrosclerosis

MalaCards organs/tissues related to Nephrosclerosis:

39
Kidney, Pituitary, Heart, Smooth Muscle, Bone, Pancreas, Endothelial

Publications for Nephrosclerosis

Articles related to Nephrosclerosis:

(show top 50) (show all 268)
id Title Authors Year
1
Clinico-pathological characteristics and outcomes of patients with biopsy-proven hypertensive nephrosclerosis: a retrospective cohort study. ( 27066888 )
2016
2
Effect of Proteinuria and Glomerular Filtration Rate on Renal Outcome in Patients with Biopsy-Proven Benign Nephrosclerosis. ( 26809068 )
2016
3
Comparison of Clinical Trajectories before Initiation of Renal Replacement Therapy between Diabetic Nephropathy and Nephrosclerosis on the KDIGO Guidelines Heat Map. ( 26839894 )
2016
4
Detection and Clinical Patterns of Nephron Hypertrophy and Nephrosclerosis Among Apparently Healthy Adults. ( 26857648 )
2016
5
Hyperuricemia as a Predictive Marker for Progression of Nephrosclerosis: Clinical Assessment of Prognostic Factors in Biopsy-Proven Arterial/Arteriolar Nephrosclerosis. ( 27784849 )
2016
6
Curcumin ameliorates nephrosclerosis via suppression of histone acetylation independent of hypertension. ( 27190365 )
2016
7
Malignant nephrosclerosis in a patient with familial Mediterranean fever. ( 26466703 )
2015
8
Patients with biopsy-proven nephrosclerosis and moderately impaired renal function have a higher risk for cardiovascular disease: 15 years' experience in a single, kidney disease center. ( 25838316 )
2015
9
The Renal Protective Effect of Jiangya Tongluo Formula, through Regulation of Adrenomedullin and Angiotensin II, in Rats with Hypertensive Nephrosclerosis. ( 26557147 )
2015
10
Nephrosclerosis: A Term in Quest of a Disease. ( 25871843 )
2015
11
Glomerular Density in Biopsy-Proven Hypertensive Nephrosclerosis. ( 25631380 )
2015
12
A multinational phase IIb/III trial of beraprost sodium, an orally active prostacyclin analogue, in patients with primary glomerular disease or nephrosclerosis (CASSIOPEIR trial), rationale and study design. ( 25233856 )
2014
13
Nephrosclerosis: update on a centenarian. ( 25488894 )
2014
14
Critical blood pressure threshold dependence of hypertensive injury and repair in a malignant nephrosclerosis model. ( 24958497 )
2014
15
Involvement of apoptosis inhibitor of macrophages in a rat hypertension model with nephrosclerosis: possible mechanisms of action of olmesartan and azelnidipine. ( 23902971 )
2013
16
Effect of intensive blood pressure control on cardiovascular remodeling in hypertensive patients with nephrosclerosis. ( 24102027 )
2013
17
Hypertensive nephrosclerosis: not enough of a good thing? ( 23283991 )
2013
18
Subclinical nephrosclerosis is linked to left ventricular hypertrophy independent of classical atherogenic factors. ( 24305517 )
2013
19
Prevalence and risk factor analysis of nephrosclerosis and ischemic nephropathy in the Japanese general population. ( 23832327 )
2013
20
Serum potassium predicts time to blood pressure response among African Americans with hypertensive nephrosclerosis. ( 23151750 )
2013
21
Castleman's disease accompanied by hypolipidemic cerebral hemorrhage and nephrosclerosis. ( 23857095 )
2013
22
Endothelial Sirtuin 1 Deficiency Perpetrates Nephrosclerosis through Downregulation of Matrix Metalloproteinase-14: Relevance to Fibrosis of Vascular Senescence. ( 24136919 )
2013
23
Aliskiren reduces home blood pressure and albuminuria in patients with hypertensive nephrosclerosis. ( 23135868 )
2013
24
Hypertension, glomerular hypertrophy and nephrosclerosis: the effect of race. ( 24327566 )
2013
25
Association of hypoalbuminemia with severe anemia in patients with diabetic nephrosclerosis. ( 22236281 )
2012
26
Arteriolar vascular smooth muscle cell differentiation in benign nephrosclerosis. ( 22319217 )
2012
27
Need for education on the differential diagnosis between chronic glomerulonephritis and nephrosclerosis, and treatment of both conditions to reduce the number of patients requiring hemodialysis in Wakayama. ( 22821095 )
2012
28
ADAMTS13--marker of contractile phenotype of arterial smooth muscle cells lost in benign nephrosclerosis. ( 20923926 )
2011
29
The role of bone morphogenetic protein-5 (BMP-5) in human nephrosclerosis. ( 21319131 )
2011
30
Expression of ACE and ACE2 in patients with hypertensive nephrosclerosis. ( 21346373 )
2011
31
Involvement of connective tissue growth factor in human and experimental hypertensive nephrosclerosis. ( 20689330 )
2011
32
Nephrosclerosis and carotid atherosclerosis: lessons from kidney donor histology. ( 21777346 )
2011
33
Senile nephrosclerosis--does it explain the decline in glomerular filtration rate with aging? ( 21832860 )
2011
34
Hypertensive nephrosclerosis in Kenya. ( 22179094 )
2011
35
Relationship between body mass index and proteinuria in hypertensive nephrosclerosis: results from the African American Study of Kidney Disease and Hypertension (AASK) cohort. ( 20801567 )
2010
36
Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis. ( 20484896 )
2010
37
Human nephrosclerosis triggers a hypoxia-related glomerulopathy. ( 20019191 )
2010
38
Rate of ESRD exceeds mortality among African Americans with hypertensive nephrosclerosis. ( 20651163 )
2010
39
The association between age and nephrosclerosis on renal biopsy among healthy adults. ( 20439574 )
2010
40
Intrarenal expression of miRNAs in patients with hypertensive nephrosclerosis. ( 19910931 )
2010
41
Bone morphogenetic protein (BMP)-7 expression is decreased in human hypertensive nephrosclerosis. ( 21080950 )
2010
42
[Molecular factors of angiogenesis in renal tissue of patients with chronic glomerulonephritis: association with nephrosclerosis and anemia]. ( 19799194 )
2009
43
Renal dysplasia and nephrosclerosis in calves. ( 19933543 )
2009
44
Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis. ( 19745105 )
2009
45
Podocyte loss in human hypertensive nephrosclerosis. ( 19131934 )
2009
46
(Pro)renin receptor peptide inhibitor "handle-region" peptide does not affect hypertensive nephrosclerosis in Goldblatt rats. ( 18212268 )
2008
47
Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats. ( 18698220 )
2008
48
Hypertensive nephrosclerosis. ( 18408477 )
2008
49
Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats. ( 17414670 )
2007
50
Effects of renin-angiotensin system blockade on macrophage infiltration in patients with hypertensive nephrosclerosis. ( 17785932 )
2007

Variations for Nephrosclerosis

Expression for Nephrosclerosis

Search GEO for disease gene expression data for Nephrosclerosis.

Pathways for Nephrosclerosis

GO Terms for Nephrosclerosis

Cellular components related to Nephrosclerosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 slit diaphragm GO:0036057 8.62 NPHS1 NPHS2

Biological processes related to Nephrosclerosis according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.69 CCL2 CTGF TGFB1
2 aging GO:0007568 9.67 CCL2 CTGF TGFB1
3 response to hypoxia GO:0001666 9.65 CCL2 MTHFR TGFB1
4 cellular response to dexamethasone stimulus GO:0071549 9.55 CCL2 TGFB1
5 protein kinase B signaling GO:0043491 9.54 CCL2 TGFB1
6 lipopolysaccharide-mediated signaling pathway GO:0031663 9.52 CCL2 TGFB1
7 response to wounding GO:0009611 9.5 CCL2 CTGF TGFB1
8 regulation of vasoconstriction GO:0019229 9.46 ACE AGTR1
9 positive regulation of cellular protein metabolic process GO:0032270 9.43 AGTR1 TGFB1
10 regulation of vasodilation GO:0042312 9.4 ACE AGTR1
11 regulation of blood vessel diameter GO:0097746 9.37 ACE AGTR1
12 response to amino acid GO:0043200 9.33 CCL2 CTGF MTHFR
13 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.26 ACE AGTR1
14 mononuclear cell proliferation GO:0032943 8.96 ACE TGFB1
15 positive regulation of collagen biosynthetic process GO:0032967 8.8 CCL2 CTGF TGFB1

Molecular functions related to Nephrosclerosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.13 BMP5 CTGF TGFB1
2 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Nephrosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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