MCID: NPH017
MIFTS: 42

Nephrosis malady

Nephrological diseases category

Summaries for Nephrosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Nephrosis refers to a non-inflammatory nephropathy. Also known as nephrotic syndrome, nephrosis is any... more...

MalaCards: Nephrosis is related to lipoid nephrosis and nephritis. An important gene associated with Nephrosis is NPHS1 (nephrosis 1, congenital, Finnish type (nephrin)), and among its related pathways are Nephrin/Neph1 signaling in the kidney podocyte and Nephrin interactions. The compounds puromycin aminonucleoside and glucosamine have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells, and related mouse phenotypes are renal/urinary system and mortality/aging.

Aliases & Classifications for Nephrosis

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11DISEASES, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

nephrosis 11 46 63


Related Diseases for Nephrosis

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18GeneCards, 19GeneDecks
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Diseases related to Nephrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1lipoid nephrosis31.4NPHS1, NPHS2
2nephritis30.7NPHS2, NPHS1
3proteinuria30.7NPHS2, NPHS1, HPSE, ACTN4
4glomerulosclerosis30.6ACTN4, NPHS1, NPHS2
5glomerulonephritis30.6NPHS2, NPHS1, ACTN4
6focal segmental glomerulosclerosis30.5NPHS2, NPHS1, ACTN4
7nephrotic syndrome30.3LAMB2, ACTN4, HPSE, PLCE1, NPHS1, NPHS2
8membranous glomerulonephritis30.3NPHS2, NPHS1
9congenital nephrotic syndrome finnish type30.2NPHS2, NPHS1, ACTN4
10endotheliitis10.4
11hepatitis10.4
12nephrosis deafness urinary tract digital malformation10.3
13anuria10.2
14hypothyroidism10.2
15hemoglobinemia10.2
16microcephaly, hiatal hernia and nephrotic syndrome10.2
17pierson syndrome10.2
18hypertension10.1
19interstitial nephritis10.1
20peritonitis10.1
21microcoria, congenital10.1
22diffuse mesangial sclerosis10.1NPHS1, NPHS2
23neuronitis10.0
24bronchitis10.0
25leukemia10.0
26prostatitis10.0
27uremia10.0
28iga glomerulonephritis10.0NEU1, NPHS1, NPHS2
29primary hyperoxaluria10.0NPHS1, NPHS2
30diabetic nephropathy10.0HPSE, NPHS1, NPHS2
31wilms tumor10.0NPHS2, NPHS1, ACTN4
32chronic kidney failure9.9NEU1, ACTN4, NPHS1, NPHS2
33tongue squamous cell carcinoma9.9HPSE, ACTN4, NEU1
34deficiency anemia9.9
35crohn's disease9.9
36cockayne syndrome9.9
37perinephritis9.9
38iritis9.9
39nail-patella syndrome9.9
40hypertensive encephalopathy9.9
41polydactyly9.9
42protein s deficiency9.9
43hypospadias9.9
44intussusception9.9
45secondary syphilis9.9
46hemolytic-uremic syndrome9.9
47eclampsia9.9
48congenital hypothyroidism9.9
49hemophilia b9.9
50cerebritis9.9

Graphical network of the top 20 diseases related to Nephrosis:



Diseases related to nephrosis

Symptoms for Nephrosis

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Drugs & Therapeutics for Nephrosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Nephrosis

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Anatomical Context for Nephrosis

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34MalaCards
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MalaCards organs/tissues related to Nephrosis:

34
Kidney, Endothelial, T cells, Monocytes, Liver, Eye, Prostate, Skin, Pituitary, Bone, Smooth muscle, Heart, Brain, Pancreatic islet, Pancreas

Animal Models for Nephrosis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Nephrosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.8NPHS2, NPHS1, ACTN4, NEU1, LAMB2
2MP:00107687.8NPHS2, NPHS1, ACTN4, NEU1, LAMB2
3MP:00053857.3NEU1, ACTN4, HPSE, PLCE1, NPHS2
4MP:00053767.3LAMB2, NEU1, ACTN4, PLCE1, NPHS1, NPHS2

Publications for Nephrosis

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53PubMed
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Articles related to Nephrosis:

(show top 50)    (show all 583)
idTitleAuthorsYear
1
Hetastarch-induced osmotic nephrosis. (22370625)
2012
2
Protective effects of Huang Qi Huai granules on adriamycin nephrosis in rats. (21359962)
2011
3
A novel DNA repair disorder with thrombocytopenia, nephrosis and features overlapping Cockayne syndrome. (19760648)
2009
4
Decreased tyrosine phosphorylation of nephrin in rat and human nephrosis. (18256598)
2008
5
Contribution of down-regulation of intestinal and hepatic cytochrome P450 3A to increased absorption of cyclosporine A in a rat nephrosis model. (18725544)
2008
6
Management of patients with recurrent nephrosis and intractable edema by intraperitoneal instillation of icodextrin solution. (18708557)
2008
7
Plasma exchange and retransplantation in recurrent nephrosis of patients with congenital nephrotic syndrome of the Finnish type (NPHS1). (17519780)
2007
8
Effect of zelandopam, a dopamine D1-like receptor agonist, in puromycin aminonucleoside nephrosis rats. (15740732)
2005
9
Role of Fat1 in cell-cell contact formation of podocytes in puromycin aminonucleoside nephrosis and neonatal kidney. (16014031)
2005
10
Cerebral thrombosis in childhood nephrosis. (15813879)
2005
11
The genetic basis of FSGS and steroid-resistant nephrosis. (12704574)
2003
12
Increased expression of CD54, CD18, MHC class II molecules, and proliferating cell nuclear antigen in acute puromycin aminonucleoside nephrosis. (12845231)
2003
13
A model for perinephric fluid accumulation in uremic rats with toxic nephrosis. (14615063)
2003
14
Stress-induced gastric lesion formation is prevented in rats with daunomycin-induced nephrosis. (10591482)
1999
15
Dose of doxorubicin determines severity of renal damage and responsiveness to ACE-inhibition in experimental nephrosis. (10598677)
1999
16
Dipyridamole and dilazep suppress oxygen radicals in puromycin aminonucleoside nephrosis rats. (9824428)
1998
17
Immunosuppressant pharmacodynamics on lymphocytes from healthy subjects and patients with chronic renal failure, nephrosis, and psoriasis: possible implications for individual therapeutic efficacy. (9433394)
1997
18
Reflex influences on renal nerve activity characteristics in nephrosis and heart failure. (9259349)
1997
19
Lipoprotein metabolism in experimental nephrosis. (8931662)
1996
20
Glomerular antigens in severe hereditary nephrosis. (8546848)
1995
21
Involvement of tumor necrosis factor and platelet-activating factor in the pathogenesis of experimental nephrosis in rats. (8176885)
1994
22
Na(+)-K(+)-ATPase activity: role in the impaired sodium excretion of experimental nephrosis in rats. (7956502)
1994
23
Increased plasma levels and effects of brain natriuretic peptide in experimental nephrosis. (8289999)
1993
24
Erythropoietin metabolism and pharmacokinetics in experimental nephrosis. (1443172)
1992
25
Growth, serum lipoproteins and apoproteins in infants with congenital nephrosis. (1451338)
1992
26
Changes of negative charge on RBC and glomeruli and its relation to the proteinuria of adriamycin nephrosis in rats. (1879220)
1991
27
Involvement of lipid mediators in the pathogenesis of experimental nephrosis in rats: its pharmacological modulation. (1659728)
1991
28
Cholestyramine resin ameliorates chronic aminonucleoside nephrosis. (2321567)
1990
29
Acute human immunodeficiency virus infection temporally associated with rhabdomyolysis, acute renal failure, and nephrosis. (2330481)
1990
30
Alterations in the glomerulus in aminonucleoside nephrosis in analbuminemic rats. (3237275)
1988
31
Decrease in the sialoglycoprotein content of the glomerular basement membrane in experimental nephrosis. (3107051)
1987
32
Exacerbation of chronic aminonucleoside nephrosis by dietary cholesterol supplementation. (3430956)
1987
33
Evaluation of T colony-stimulating factor in patients with lipoid nephrosis. (3484545)
1986
34
Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. (4038407)
1985
35
The effect of captopril on urinary protein excretion in puromycin aminonucleoside nephrosis in rats. (3898001)
1985
36
Localization of sialic acid in kidney glomeruli: regionalization in the podocyte plasma membrane and loss in experimental nephrosis. (3866237)
1985
37
Glomerular permeability and polyanion in adriamycin nephrosis in the rat. (6195386)
1983
38
HLA-DR 7 in adult lipoid nephrosis patients. Significant difference according to the age of onset. (6603586)
1983
39
Effect of thymic humoral factor on a local graft-versus-host reaction of lymphocytes in patients with lipoid nephrosis. (6984140)
1982
40
Increased hepatitic cholesterol production due to liver hypertrophy in rat experimental nephrosis. (7055597)
1982
41
Serum 25 (OH) D and 24,25 (OH)2 levels in childhood nephrosis under different therapeutic regimens of steroid administration. (7094938)
1982
42
Congenital lipoid nephrosis with left renal vein thrombosis and Chiari's syndrome. (468879)
1979
43
Lipoid nephrosis and focal glomerulosclerosis. (355987)
1978
44
Nephrotic syndrome with minimal glomerular lesions (lipoid nephrosis) in an adult diabetic patient. (576799)
1977
45
Hodgkin's disease and lipoid nephrosis. (67327)
1977
46
Natural history of childhood lipoid nephrosis. (4713549)
1973
47
Glomerular localisation of IgE in lipoid nephrosis. (4122790)
1973
48
Lipoid nephrosis in Hodgkin's disease. (4554878)
1972
49
Histometrical glomerular studies on the kidneys in multiple myeloma and in acute membranous glomerulonephritis (lipoid nephrosis). (5145535)
1971
50
Histochemical distribution of glycogen II. In the kidneys of patients with different pathological conditions, especially those with lipoid nephrosis. (14818524)
1951

Variations for Nephrosis

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Expression for genes affiliated with Nephrosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephrosis

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Pathways for genes affiliated with Nephrosis

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51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG
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Compounds for genes affiliated with Nephrosis

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46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB
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Compounds related to Nephrosis according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1puromycin aminonucleoside469.9NPHS1, NPHS2
2glucosamine46 25 1211.5HPSE, NEU1
3n-acetylglucosamine469.4HPSE, NEU1
4chondroitin sulfate46 2510.3NEU1, HPSE
5agarose469.3HPSE, NEU1
6creatinine469.2NPHS2, NPHS1, HPSE
7mannose 6-phosphate46 2510.0HPSE, NEU1
8steroid469.0NPHS2, NPHS1, HPSE
9heparin46 30 25 1212.0LAMB2, NEU1, HPSE
10serine468.2NPHS1, HPSE, ACTN4, NEU1
11calcium46 52 25 1210.5NPHS2, NPHS1, PLCE1, HPSE, ACTN4, LAMB2

GO Terms for genes affiliated with Nephrosis

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17Gene Ontology
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Cellular components related to Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:0360579.8NPHS2, NPHS1
2cell-cell junctionGO:0059119.2NPHS2, ACTN4
3membrane raftGO:0451219.1HPSE, NPHS1, NPHS2
4lysosomal lumenGO:0432029.0HPSE, NEU1
5protein complexGO:0432348.8NPHS2, NPHS1, ACTN4
6extracellular vesicular exosomeGO:0700627.9NPHS2, NPHS1, ACTN4, NEU1, LAMB2

Biological processes related to Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid catabolic processGO:0160429.5PLCE1, NEU1
2metanephric glomerular visceral epithelial cell developmentGO:0722499.4NPHS2, LAMB2
3excretionGO:0075889.4NPHS2, NPHS1

Molecular functions related to Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:0051789.1ACTN4, LAMB2

Products for genes affiliated with Nephrosis

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Sources for Nephrosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet