MCID: NPH017
MIFTS: 42

Nephrosis malady

Nephrological diseases category
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Summaries for Nephrosis

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Wikipedia:65 Nephrosis refers to a non-inflammatory nephropathy. Also known as nephrotic syndrome, nephrosis is any... more...

MalaCards based summary: Nephrosis is related to lipoid nephrosis and nephritis. An important gene associated with Nephrosis is NPHS1 (nephrosis 1, congenital, Finnish type (nephrin)), and among its related pathways are Nephrin/Neph1 signaling in the kidney podocyte and Nephrin interactions. The compounds puromycin aminonucleoside and glucosamine have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells, and related mouse phenotypes are renal/urinary system and mortality/aging.

Aliases & Classifications for Nephrosis

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Sources:
10DISEASES, 44Novoseek, 62UMLS
See all sources

Nephrosis, Aliases & Descriptions:

Name: Nephrosis 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Related Diseases for Nephrosis

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Diseases related to Nephrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1lipoid nephrosis31.6NPHS2, NPHS1
2nephritis30.9NPHS1, NPHS2
3glomerulosclerosis30.6ACTN4, NPHS2, NPHS1
4membranous glomerulonephritis30.5NPHS1, NPHS2
5glomerulonephritis30.4NPHS1, ACTN4, NPHS2
6focal segmental glomerulosclerosis30.4NPHS2, ACTN4, NPHS1
7proteinuria30.3NPHS2, NPHS1, HPSE, ACTN4
8congenital nephrotic syndrome finnish type30.1ACTN4, NPHS2, NPHS1
9nephrotic syndrome29.5NPHS1, HPSE, ACTN4, LAMB2, PLCE1, NPHS2
10endotheliitis10.4
11hepatitis10.4
12microcephaly, hiatal hernia and nephrotic syndrome10.3
13nephrosis deafness urinary tract digital malformation10.3
14diffuse mesangial sclerosis10.2NPHS2, NPHS1
15anuria10.2
16hypothyroidism10.2
17hemoglobinemia10.2
18pierson syndrome10.2
19hypertension10.1
20interstitial nephritis10.1
21peritonitis10.1
22microcoria, congenital10.1
23leukemia10.1
24bronchitis10.1
25neuronitis10.1
26prostatitis10.1
27uremia10.1
28nephrotic syndrome, type 110.1
29berger disease10.0NEU1, NPHS1, NPHS2
30primary hyperoxaluria10.0NPHS1, NPHS2
31diabetic nephropathy9.9HPSE, NPHS2, NPHS1
32deficiency anemia9.9
33acute lymphoblastic leukemia9.9
34asphyxia neonatorum9.9
35crohn's disease9.9
36hemolytic anemia9.9
37hodgkin's lymphoma9.9
38ischemic optic neuropathy9.9
39multiple myeloma9.9
40osteoporosis9.9
41thrombocytopenia9.9
42cockayne syndrome9.9
43perinephritis9.9
44ochronosis9.9
45iritis9.9
46polydactyly9.9
47eclampsia9.9
48crescentic glomerulonephritis9.9
49nail-patella syndrome9.9
50hypertensive encephalopathy9.9

Graphical network of the top 20 diseases related to Nephrosis:



Diseases related to nephrosis

Symptoms for Nephrosis

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Drugs & Therapeutics for Nephrosis

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Drug clinical trials:

Search ClinicalTrials for Nephrosis

Search NIH Clinical Center for Nephrosis

Genetic Tests for Nephrosis

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Anatomical Context for Nephrosis

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MalaCards organs/tissues related to Nephrosis:

32
Kidney, Endothelial, T cells, Liver, Monocytes, Eye, Bone, Skin, Prostate, Pituitary, Brain, Heart, Smooth muscle, Pancreas, Pancreatic islet, Neutrophil

Animal Models for Nephrosis or affiliated genes

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MGI Mouse Phenotypes related to Nephrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.8NPHS2, NPHS1, ACTN4, NEU1, LAMB2
2MP:00107687.8NPHS2, NPHS1, ACTN4, NEU1, LAMB2
3MP:00053857.3NEU1, ACTN4, HPSE, PLCE1, NPHS2
4MP:00053767.3LAMB2, NEU1, ACTN4, PLCE1, NPHS1, NPHS2

Publications for Nephrosis

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Articles related to Nephrosis:

(show top 50)    (show all 591)
idTitleAuthorsYear
1
Plasma biochemistry and urinalysis variables of koalas (Phascolarctos cinereus) with and without oxalate nephrosis. (24773087)
2014
2
Hetastarch-induced osmotic nephrosis. (22370625)
2012
3
Protective effects of Huang Qi Huai granules on adriamycin nephrosis in rats. (21359962)
2011
4
A novel DNA repair disorder with thrombocytopenia, nephrosis and features overlapping Cockayne syndrome. (19760648)
2009
5
Decreased tyrosine phosphorylation of nephrin in rat and human nephrosis. (18256598)
2008
6
Contribution of down-regulation of intestinal and hepatic cytochrome P450 3A to increased absorption of cyclosporine A in a rat nephrosis model. (18725544)
2008
7
Management of patients with recurrent nephrosis and intractable edema by intraperitoneal instillation of icodextrin solution. (18708557)
2008
8
Plasma exchange and retransplantation in recurrent nephrosis of patients with congenital nephrotic syndrome of the Finnish type (NPHS1). (17519780)
2007
9
Effect of zelandopam, a dopamine D1-like receptor agonist, in puromycin aminonucleoside nephrosis rats. (15740732)
2005
10
Role of Fat1 in cell-cell contact formation of podocytes in puromycin aminonucleoside nephrosis and neonatal kidney. (16014031)
2005
11
Cerebral thrombosis in childhood nephrosis. (15813879)
2005
12
The genetic basis of FSGS and steroid-resistant nephrosis. (12704574)
2003
13
Increased expression of CD54, CD18, MHC class II molecules, and proliferating cell nuclear antigen in acute puromycin aminonucleoside nephrosis. (12845231)
2003
14
Collecting duct is a site of sodium retention in PAN nephrosis: a rationale for amiloride therapy. (11181809)
2001
15
Stress-induced gastric lesion formation is prevented in rats with daunomycin-induced nephrosis. (10591482)
1999
16
Dose of doxorubicin determines severity of renal damage and responsiveness to ACE-inhibition in experimental nephrosis. (10598677)
1999
17
Dipyridamole and dilazep suppress oxygen radicals in puromycin aminonucleoside nephrosis rats. (9824428)
1998
18
Immunosuppressant pharmacodynamics on lymphocytes from healthy subjects and patients with chronic renal failure, nephrosis, and psoriasis: possible implications for individual therapeutic efficacy. (9433394)
1997
19
Reflex influences on renal nerve activity characteristics in nephrosis and heart failure. (9259349)
1997
20
Lipoprotein metabolism in experimental nephrosis. (8931662)
1996
21
Glomerular antigens in severe hereditary nephrosis. (8546848)
1995
22
Involvement of tumor necrosis factor and platelet-activating factor in the pathogenesis of experimental nephrosis in rats. (8176885)
1994
23
Na(+)-K(+)-ATPase activity: role in the impaired sodium excretion of experimental nephrosis in rats. (7956502)
1994
24
Increased plasma levels and effects of brain natriuretic peptide in experimental nephrosis. (8289999)
1993
25
Erythropoietin metabolism and pharmacokinetics in experimental nephrosis. (1443172)
1992
26
Growth, serum lipoproteins and apoproteins in infants with congenital nephrosis. (1451338)
1992
27
Changes of negative charge on RBC and glomeruli and its relation to the proteinuria of adriamycin nephrosis in rats. (1879220)
1991
28
Involvement of lipid mediators in the pathogenesis of experimental nephrosis in rats: its pharmacological modulation. (1659728)
1991
29
Cholestyramine resin ameliorates chronic aminonucleoside nephrosis. (2321567)
1990
30
Acute human immunodeficiency virus infection temporally associated with rhabdomyolysis, acute renal failure, and nephrosis. (2330481)
1990
31
Alterations in the glomerulus in aminonucleoside nephrosis in analbuminemic rats. (3237275)
1988
32
Decrease in the sialoglycoprotein content of the glomerular basement membrane in experimental nephrosis. (3107051)
1987
33
Exacerbation of chronic aminonucleoside nephrosis by dietary cholesterol supplementation. (3430956)
1987
34
Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. (4038407)
1985
35
The effect of captopril on urinary protein excretion in puromycin aminonucleoside nephrosis in rats. (3898001)
1985
36
Localization of sialic acid in kidney glomeruli: regionalization in the podocyte plasma membrane and loss in experimental nephrosis. (3866237)
1985
37
Glomerular permeability and polyanion in adriamycin nephrosis in the rat. (6195386)
1983
38
HLA-DR 7 in adult lipoid nephrosis patients. Significant difference according to the age of onset. (6603586)
1983
39
Effect of thymic humoral factor on a local graft-versus-host reaction of lymphocytes in patients with lipoid nephrosis. (6984140)
1982
40
Increased hepatitic cholesterol production due to liver hypertrophy in rat experimental nephrosis. (7055597)
1982
41
Serum 25 (OH) D and 24,25 (OH)2 levels in childhood nephrosis under different therapeutic regimens of steroid administration. (7094938)
1982
42
Congenital lipoid nephrosis with left renal vein thrombosis and Chiari's syndrome. (468879)
1979
43
Lipoid nephrosis and focal glomerulosclerosis. (355987)
1978
44
Nephrotic syndrome with minimal glomerular lesions (lipoid nephrosis) in an adult diabetic patient. (576799)
1977
45
Hodgkin's disease and lipoid nephrosis. (67327)
1977
46
Natural history of childhood lipoid nephrosis. (4713549)
1973
47
Glomerular localisation of IgE in lipoid nephrosis. (4122790)
1973
48
Lipoid nephrosis in Hodgkin's disease. (4554878)
1972
49
Histometrical glomerular studies on the kidneys in multiple myeloma and in acute membranous glomerulonephritis (lipoid nephrosis). (5145535)
1971
50
Histochemical distribution of glycogen II. In the kidneys of patients with different pathological conditions, especially those with lipoid nephrosis. (14818524)
1951

Variations for Nephrosis

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Expression for genes affiliated with Nephrosis

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Expression patterns in normal tissues for genes affiliated with Nephrosis

Search GEO for disease gene expression data for Nephrosis.

Pathways for genes affiliated with Nephrosis

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Compounds for genes affiliated with Nephrosis

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 50PharmGKB
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Compounds related to Nephrosis according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1puromycin aminonucleoside449.9NPHS1, NPHS2
2glucosamine44 24 1111.5HPSE, NEU1
3n-acetylglucosamine449.4HPSE, NEU1
4chondroitin sulfate44 2410.3NEU1, HPSE
5agarose449.3HPSE, NEU1
6creatinine449.2NPHS2, NPHS1, HPSE
7mannose 6-phosphate44 2410.0HPSE, NEU1
8steroid449.0NPHS2, NPHS1, HPSE
9heparin44 28 24 1112.0LAMB2, NEU1, HPSE
10serine448.2NPHS1, HPSE, ACTN4, NEU1
11calcium44 50 24 1110.5NPHS2, NPHS1, PLCE1, HPSE, ACTN4, LAMB2

GO Terms for genes affiliated with Nephrosis

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Cellular components related to Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:0360579.8NPHS2, NPHS1
2cell-cell junctionGO:0059119.2NPHS2, ACTN4
3membrane raftGO:0451219.1HPSE, NPHS1, NPHS2
4lysosomal lumenGO:0432029.0HPSE, NEU1
5protein complexGO:0432348.8NPHS2, NPHS1, ACTN4
6extracellular vesicular exosomeGO:0700627.9NPHS2, NPHS1, ACTN4, NEU1, LAMB2

Biological processes related to Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipid catabolic processGO:0160429.5PLCE1, NEU1
2metanephric glomerular visceral epithelial cell developmentGO:0722499.4NPHS2, LAMB2
3excretionGO:0075889.4NPHS2, NPHS1

Molecular functions related to Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:0051789.1ACTN4, LAMB2

Products for genes affiliated with Nephrosis

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  • Antibodies
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Sources for Nephrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet