MCID: NPH017
MIFTS: 33

Nephrosis malady

Nephrological diseases category

Summaries for Nephrosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Nephrosis refers to a non-inflammatory nephropathy. Also known as nephrotic syndrome, nephrosis is any... more...

MalaCards: Nephrosis is related to lipoid nephrosis and proteinuria. An important gene associated with Nephrosis is NPHS1 (nephrosis 1, congenital, Finnish type (nephrin)), and among its related pathways are Nephrin interactions and Amoebiasis. The compounds Bismuth Subsalicylate and vitamin a have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are renal/urinary system and growth/size.

Aliases & Classifications for Nephrosis

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10DISEASES, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

nephrosis 10 44 60


Related Diseases for Nephrosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Nephrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1lipoid nephrosis31.3NPHS1, NPHS2, TF, IL13, ALB
2proteinuria30.8APOA2, NPHS1, NPHS2, TF, HBEGF, HPSE
3glomerulonephritis30.5NPHS1, NPHS2, HBEGF, ACTN4, ALB
4nephrotic syndrome30.5NPHS1, NPHS2, TF, HPSE, IL13, PLCE1
5focal segmental glomerulosclerosis30.5NPHS1, NPHS2, ACTN4, ALB
6membranous glomerulonephritis30.2NPHS1, NPHS2, ALB
7peritonitis30.1ALB
8hypertension30.1ALB
9leukemia30.0HBEGF, HPSE, SERPINF2
10crohn's disease29.7ALB
11myopathy29.7LAMB2, TFAM
12deficiency anemia29.7ALB, TF
13amyloidosis29.7ALB, APOA2
14pancreatitis29.7ALB, IL10
15thrombocytopenia29.7HPSE, ALB
16myeloma29.7ALB, HPSE, HBEGF, NEU1
17psoriasis29.7HBEGF, IL13, IL10, SERPINF2
18pre-eclampsia29.7NPHS1, NPHS2, HBEGF, IL10, SERPINF2
19focal glomerulosclerosis10.4
20hepatitis10.3
21nephrosis deafness urinary tract digital malformation10.2
22anuria10.1
23hypothyroidism10.1
24congenital nephrotic syndrome finnish type10.1
25microcephaly, hiatal hernia and nephrotic syndrome10.1
26congenital hypothyroidism10.1
27interstitial nephritis10.1
28neuronitis10.0
29bronchitis10.0
30hepatitis a10.0
31prostatitis10.0
32uremia10.0
33pierson syndrome10.0
34esophagitis10.0IL13
35colorectal cancer10.0HPSE
36thromboembolism10.0SERPINF2
37acute myocardial infarction10.0SERPINF2
38skin disease10.0ALB
39periodontal disease10.0SERPINF2
40pulmonary fibrosis10.0IL13
41hyperparathyroidism10.0ALB
42cystic fibrosis10.0ALB
43inflammatory bowel disease10.0IL10
44myeloid leukemia10.0NEU1
45polyneuropathy10.0APOA2
46fasciitis10.0ACTC1
47essential hypertension10.0ALB
48congenital disorder of glycosylation10.0TF
49diffuse mesangial sclerosis10.0NPHS2, NPHS1
50lupus nephritis10.0ALB, IL10

Graphical network of the top 20 diseases related to Nephrosis:



Diseases related to nephrosis

Clinical Features for Nephrosis

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Drugs & Therapeutics for Nephrosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Nephrosis

Drug clinical trials:

Search ClinicalTrials for Nephrosis

Search NIH Clinical Center for Nephrosis

Search CenterWatch for Nephrosis

Genetic Tests for Nephrosis

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Anatomical Context for Nephrosis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Nephrosis:

32
Kidney

Animal Models for Nephrosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Nephrosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.7NPHS2, GALNS, NEU1, ACTN4, LAMB2, ALB
2MP:00053789.2APOA2, NPHS2, TF, LAMB2, ACTN4, ACTC1
3MP:00053859.2NEU1, ACTC1, PLCE1, IL10, HPSE, HBEGF
4MP:00107689.1IL13, NEU1, ALB, LAMB2, ACTN4, NPHS1
5MP:00053768.7IL10, SERPINF2, IL13, ALB, HBEGF, LAMB2

Publications for Nephrosis

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Genetic Variations for Nephrosis

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Expression for genes affiliated with Nephrosis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephrosis

Search GEO for disease gene expression data for Nephrosis.

Pathways for genes affiliated with Nephrosis

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Sources:
53Reactome, 29KEGG, 51QIAGEN
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Pathways related to Nephrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2NPHS1, NPHS2, ACTN4
210.2ACTN4, IL10, LAMB2
3
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10.0TF, ACTN4, SERPINF2, ALB
4
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9.9TFAM, IL13, IL10, PLCE1, ACTN4
5
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9.8ACTN4, PLCE1, LAMB2, IL10, IL13, TFAM

Compounds for genes affiliated with Nephrosis

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Sources:
11DrugBank, 44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Nephrosis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1Bismuth Subsalicylate1110.7TF, ALB
2vitamin a44 11 2412.7HBEGF
3kp-10194410.7TF, ALB
4ovomucoid4410.6TF
5tacrolimus44 49 1112.6IL13, ALB
6puromycin aminonucleoside4410.6NPHS1, NPHS2, HBEGF
7triamcinolone acetonide44 2811.6TF, NEU1, IL10
8streptomycin44 1111.5IL10, TF
9glutaraldehyde4410.5TF, NEU1, ALB
10bismuth44 2411.5ALB, TF
11aspartate4410.5GALNS, ALB
12gelfoam4410.5TF, ALB
13cellulose acetate4410.5ALB, NEU1, GALNS
14alpha-galactosylceramide4410.5IL13, IL10
15acetaldehyde44 28 2412.5TF, IL10, ALDH3A2
16ribavirin44 49 1112.5IL10, NEU1, TF
17glucosamine44 11 2412.5HPSE, NEU1, GALNS
18prednisolone44 28 1112.4TF, IL13, IL10, ALB
19cyclophosphamide44 49 1112.4IL10, IL13, TF, NPHS2
20suprofen44 1111.4TF, ALB
21chondroitin sulfate44 2411.4GALNS, NEU1, HBEGF, HPSE
22chlorate4410.4GALNS, HBEGF
23hyaluronic acid44 2411.4GALNS, NEU1, IL13, ALB
24glycosaminoglycan4410.4GALNS, HBEGF, HPSE, ACTC1
25agarose4410.4APOA2, GALNS, NEU1, HPSE
26thyroxine44 2411.3TF, IL13, IL10, SERPINF2, ALB
27histamine44 28 2412.3TF, NEU1, IL13, IL10, ALB
28heparan sulfate44 2411.3SERPINF2, HPSE, HBEGF, GALNS
29glucose4410.3GNPDA1, APOA2, NPHS1, HPSE, ACTC1
30creatinine4410.3NPHS1, NPHS2, TF, HPSE, ACTC1, ALB
31paraffin4410.2TF, NEU1, HBEGF, IL10, ACTC1
32n-acetylglucosamine4410.2HPSE, NEU1, GNPDA1
33fibrinogen4410.2APOA2, TF, HBEGF, SERPINF2, ALB
34zidovudine44 1111.2NEU1, IL10, ALB
35cyclosporin a44 28 5912.2NPHS2, GALNS, TF, IL13, IL10, ACTC1
36steroid4410.2NPHS1, NPHS2, HPSE, IL13, ACTC1, ALDH3A2
37glutamine4410.2SERPINF2, IL13, TFAM, TF, APOA2
38heparin44 28 11 2413.2LAMB2, IL13, HBEGF, NEU1, GALNS, APOA2
39polyethylene glycol4410.2ALB, NEU1, TF
40biotin44 11 2412.1ACTC1, IL10, TF
41serine4410.1APOA2, NPHS1, GALNS, NEU1, IL13, ACTN4
42polysaccharide4410.1GALNS, TF, NEU1, HBEGF, HPSE, IL13
43alanine4410.1TF, HBEGF, HPSE, IL13, SERPINF2, ALB
44alpha tocopherol4410.0TF, IL13, ALB
45vegf4410.0NPHS1, TF, HBEGF, HPSE, IL13, IL10
46lipid4410.0APOA2, NPHS1, NPHS2, HBEGF, HPSE, SERPINF2
47mip 1alpha4410.0IL10, IL13
48retinoic acid44 2410.9APOA2, NPHS1, NEU1, HBEGF, IL13, ACTC1
49calcium44 49 11 2412.4TFAM, GALNS, NPHS2, NPHS1, GNPDA1, HBEGF

GO Terms for genes affiliated with Nephrosis

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Sources:
16Gene Ontology
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Cellular components related to Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:03605710.2NPHS2, NPHS1
2platelet alpha granule lumenGO:03109310.1ACTN4, SERPINF2, ALB
3extracellular vesicular exosomeGO:07006210.1ALB, ACTN4, ACTC1
4lysosomal lumenGO:0432029.8HPSE, NEU1, GALNS
5extracellular regionGO:0055769.6ALB, SERPINF2, ACTN4, IL13, HPSE, HBEGF

Biological processes related to Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular visceral epithelial cell developmentGO:07224910.3LAMB2, NPHS2
2platelet degranulationGO:00257610.1ALB, SERPINF2, ACTN4, TF
3platelet activationGO:03016810.0ALB, ACTN4, TF, SERPINF2
4positive regulation of smooth muscle cell proliferationGO:04866110.0SERPINF2, IL13, HBEGF
5negative regulation of cytokine secretion involved in immune responseGO:0027409.9APOA2, IL10

Products for genes affiliated with Nephrosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nephrosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet