MCID: NPH017
MIFTS: 45

Nephrosis malady

Nephrological category

Summaries for Nephrosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Nephrosis refers to a non-inflammatory nephropathy. Also known as nephrotic syndrome, nephrosis is any... more...

MalaCards: Nephrosis is related to lipoid nephrosis and nephritis. An important gene associated with Nephrosis is NPHS1 (nephrosis 1, congenital, Finnish type (nephrin)), and among its related pathways are Nephrin interactions and Amoebiasis. The compounds Bismuth Subsalicylate and vitamin a have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and heart, and related mouse phenotypes are renal/urinary system and growth/size.

Aliases & Classifications for Nephrosis

Sources:
10DISEASES, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Aliases & Descriptions:

nephrosis 10 45 61


Related Diseases for Nephrosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Nephrosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1lipoid nephrosis31.3NPHS1, NPHS2, TF, IL13, ALB
2nephritis30.7ALB, NPHS2, NPHS1
3focal segmental glomerulosclerosis30.5NPHS1, NPHS2, ACTN4, ALB
4membranous glomerulonephritis30.2NPHS1, NPHS2, ALB
5deficiency anemia29.8ALB, TF
6amyloidosis29.8ALB, APOA2
7thrombocytopenia29.8HPSE, ALB
8hypercholesterolemia29.8SERPINF2, APOA2
9n syndrome10.6
10focal glomerulosclerosis10.4
11lip disease10.4
12congenital nephrotic syndrome finnish type10.3
13pierson syndrome10.3
14nephrosis deafness urinary tract digital malformation10.3
15anuria10.2
16micro syndrome10.2
17microcoria, congenital10.2
18microcephaly, hiatal hernia and nephrotic syndrome10.2
19hemoglobinemia10.2
20congenital hypothyroidism10.1
21bronchitis10.0
22uremia10.0
23esophagitis10.0IL13
24colorectal cancer10.0HPSE
25peritonitis10.0ALB
26thromboembolism10.0SERPINF2
27acute myocardial infarction10.0SERPINF2
28skin disease10.0ALB
29periodontal disease10.0SERPINF2
30pulmonary fibrosis10.0IL13
31hyperparathyroidism10.0ALB
32cystic fibrosis10.0ALB
33inflammatory bowel disease10.0IL10
34myeloid leukemia10.0NEU1
35crohn's disease10.0ALB
36polyneuropathy10.0APOA2
37fasciitis10.0ACTC1
38essential hypertension10.0ALB
39congenital disorder of glycosylation10.0TF
40diffuse mesangial sclerosis10.0NPHS2, NPHS1
41lupus nephritis10.0ALB, IL10
42hypertension10.0ALB
43allergic rhinitis10.0IL10, IL13
44tuberculosis10.0ALB, IL10
45lung cancer10.0ALB
46myopathy10.0LAMB2, TFAM
47rhinitis10.0IL13, ALB
48gangliosidosis gm110.0NEU1
49myocardial infarction10.0SERPINF2, APOA2
50diabetic retinopathy10.0ALB

Graphical network of the top 20 diseases related to Nephrosis:



Diseases related to nephrosis

Clinical Features for Nephrosis

Drugs & Therapeutics for Nephrosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Nephrosis

Drug clinical trials:

Search ClinicalTrials for Nephrosis

Search NIH Clinical Center for Nephrosis

Search CenterWatch for Nephrosis

Genetic Tests for Nephrosis

Anatomical Context for Nephrosis

Sources:
33MalaCards
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MalaCards organs/tissues related to Nephrosis:

33
Bone marrow, Brain, Heart, Smooth muscle, Kidney, Liver, Pancreas, Skin, Prostate, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Pancreatic islet, Pituitary

Animal Models for Nephrosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Nephrosis

Sources:
51PubMed
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Articles related to Nephrosis:

(show top 50)    (show all 591)
idTitleAuthorsYear
1
Experimentally induced puromycine aminonucleoside nephrosis (PAN) in rats: evaluation of angiogenic protein platelet-derived endothelial cell growth factor (PD-ECGF) expression in glomeruli. (22335899)
2012
2
Osmotic nephrosis due to the use of anti-adhesive membrane intraperitoneally. (20605839)
2011
3
Increased expression of olfactomedin-1 and myocilin in podocytes during puromycin aminonucleoside nephrosis. (20595200)
2011
4
The CD40-CD154 co-stimulation pathway mediates innate immune injury in adriamycin nephrosis. (19889873)
2010
5
Renoprotective effect of the L/N-type calcium channel antagonist cilnidipine on puromycin aminonucleoside-induced nephrosis in rats. (19338138)
2009
6
The pathology of jaundice-related renal insufficiency: cholemic nephrosis revisited. (16736428)
2006
7
Increased expression of apoptosis-associated proteins in puromycin aminonucleoside nephrosis. (16152783)
2005
8
Unusual sites of Hodgkin's lymphoma: CASE 3. Cholemic nephrosis in Hodgkin's lymphoma with liver involvement. (15483036)
2004
9
Congenital nephrosis, mesangial sclerosis, and distinct eye abnormalities with microcoria: an autosomal recessive syndrome. (15372515)
2004
10
The genetic basis of FSGS and steroid-resistant nephrosis. (12704574)
2003
11
Garlic ameliorates hyperlipidemia in chronic aminonucleoside nephrosis. (11055549)
2000
12
Mesangial proliferative nephrosis with superimposed focal segmental glomerulosclerosis versus idiopathic nephrosis with focal segmental glomerulosclerosis. (10575301)
1999
13
Endogenous asymmetrical dimethylarginine and hypertension associated with puromycin nephrosis in the rat. (9806329)
1998
14
Pre- and postnatal growth retardation, scaling skin, moderate mental retardation and quadrispasticity, hypospadias grade 2 and hydro-uretero nephrosis, postaxial polydactyly. A distinct MCA/MR syndrome? (9823494)
1998
15
Observation on the content of plasma lipoperoxide and serum superoxide dismutase in NIDDM nephrosis patients]. (10453573)
1997
16
Gene expression of lipoprotein lipase in experimental nephrosis. (9358077)
1997
17
Acquired free protein S deficiency in children with steroid resistant nephrosis. (8726222)
1996
18
Gene expression of hepatic cholesterol 7 alpha-hydroxylase in the course of puromycin-induced nephrosis. (8648930)
1996
19
Management of idiopathic nephrosis in adults, including steroid-resistant nephrosis. (7600048)
1995
20
Na(+)-K(+)-ATPase activity: role in the impaired sodium excretion of experimental nephrosis in rats. (7956502)
1994
21
Side effects of levamisole in children with nephrosis. (8018513)
1994
22
Uninephrectomy aggravates tubulointerstitial injury in rats with adriamycin nephrosis. (8139738)
1994
23
Cyclosporine in the treatment of idiopathic nephrosis. (7849244)
1994
24
Comparison of the susceptibility of chicks of different ages to infection with nephrosis/nephritis-causing strain of infectious bronchitis virus. (7948371)
1994
25
Angiotensin I converting enzyme activity in adriamycin induced nephrosis in rats. (8303709)
1993
26
Altered glomerular steady-state levels of tumour necrosis factor-alpha mRNA during nephrotic and sclerotic phases of puromycin aminonucleoside nephrosis in rats. (8384958)
1993
27
Cyclosporin reduces proteinuria in rats with aminonucleoside nephrosis. (1517884)
1992
28
Involvement of thromboxane A2, leukotrienes and free radicals in puromycin nephrosis in rats. (2067208)
1991
29
Congenital nephrosis as a cause of elevated alpha-fetoprotein. (1699188)
1990
30
Nephrosis, peritonitis and complement deficiency. (2242328)
1990
31
Alterations in the glomerulus in aminonucleoside nephrosis in analbuminemic rats. (3237275)
1988
32
Heterogeneity of glomerular barrier function in early adriamycin nephrosis of MWF rats. (3208483)
1988
33
Status of glomerular proteoglycans in aminonucleoside nephrosis. (2441105)
1987
34
Increased glomerular thromboxane synthesis as a possible cause of proteinuria in experimental nephrosis. (4038407)
1985
35
Permselectivity and proteinuria in 'minimal-lesion' nephrosis. (3969508)
1985
36
Accumulation of laminin and type IV collagen in the kidney in congenital nephrosis. (3892133)
1985
37
Is house dust allergen a possible causal factor for relapses in lipoid nephrosis? (6711772)
1984
38
Antenatal screening for congenital nephrosis in Finland by maternal serum alpha-fetoprotein. (6189511)
1983
39
Serum factors in experimental nephrosis prevent lymphocyte stimulation. (7165581)
1982
40
Current estimates of the incidence of steroid responsive idiopathic nephrosis in Kentucky children 1-9 years of age. (7201982)
1982
41
Lipoid nephrosis appearing as acute oliguric renal failure. (7362359)
1980
42
Postural proteinuria and lipoid nephrosis of 58 years' duration. (1009389)
1976
43
Minimal change and focal sclerotic lesions in lipoid nephrosis. (4368918)
1974
44
Glomerular localisation of IgE in lipoid nephrosis. (4122790)
1973
45
Histometrical glomerular studies on the kidneys in multiple myeloma and in acute membranous glomerulonephritis (lipoid nephrosis). (5145535)
1971
46
Cobalt-induced hypothyroidism and polycythemia in lipoid nephrosis. (5710037)
1968
47
Experimental studies in hemoglobinuric nephrosis. II. The enhanced effect on the kidneys of glycerol-induced hemoglobinemia combined with unilateral nephrectomy. (13669985)
1959
48
Experimental studies in hemoglobinuric nephrosis. Part 3. The effect of acute hemolytic anemia (hemoglobinemia) combined with ten minutes' unilateral renal ischemia on the morphology and function of the rabbit's kidneys. (13821371)
1959
49
Bone diseases and lipoid nephrosis]. (13595983)
1958
50
Heparin in lipoid nephrosis; observations of the effects on edema, proteinuria, serum proteins, lipids and lipoproteins. (13196959)
1954

Genetic Variations for Nephrosis

Expression for genes affiliated with Nephrosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephrosis

Search GEO for disease gene expression data for Nephrosis.

Pathways for genes affiliated with Nephrosis

Sources:
54Reactome, 30KEGG, 52QIAGEN
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Pathways related to Nephrosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ACTN4, NPHS2, NPHS1
210.2LAMB2, ACTN4, IL10
3
Hide members
10.0ALB, SERPINF2, ACTN4, TF
4
Hide members
9.9TFAM, IL13, IL10, PLCE1, ACTN4
5
Hide members
9.8TFAM, IL13, IL10, PLCE1, ACTN4, LAMB2

Compounds for genes affiliated with Nephrosis

Sources:
11DrugBank, 45Novoseek, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Nephrosis according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1Bismuth Subsalicylate1110.7TF, ALB
2vitamin a45 11 2412.7HBEGF
3kp-10194510.7TF, ALB
4ovomucoid4510.6TF
5tacrolimus45 50 1112.6IL13, ALB
6puromycin aminonucleoside4510.6NPHS1, NPHS2, HBEGF
7triamcinolone acetonide45 2911.6TF, NEU1, IL10
8streptomycin45 1111.5IL10, TF
9glutaraldehyde4510.5TF, NEU1, ALB
10bismuth45 2411.5ALB, TF
11aspartate4510.5GALNS, ALB
12gelfoam4510.5TF, ALB
13cellulose acetate4510.5ALB, NEU1, GALNS
14alpha-galactosylceramide4510.5IL13, IL10
15acetaldehyde45 29 2412.5TF, IL10, ALDH3A2
16ribavirin45 50 1112.5IL10, NEU1, TF
17glucosamine45 11 2412.5HPSE, NEU1, GALNS
18prednisolone45 29 1112.4TF, IL13, IL10, ALB
19cyclophosphamide45 50 1112.4IL10, IL13, TF, NPHS2
20suprofen45 1111.4TF, ALB
21chondroitin sulfate45 2411.4GALNS, NEU1, HBEGF, HPSE
22chlorate4510.4GALNS, HBEGF
23hyaluronic acid45 2411.4GALNS, NEU1, IL13, ALB
24glycosaminoglycan4510.4GALNS, HBEGF, HPSE, ACTC1
25agarose4510.4APOA2, GALNS, NEU1, HPSE
26thyroxine45 2411.3TF, IL13, IL10, SERPINF2, ALB
27histamine45 29 2412.3TF, NEU1, IL13, IL10, ALB
28heparan sulfate45 2411.3SERPINF2, HPSE, HBEGF, GALNS
29glucose4510.3GNPDA1, APOA2, NPHS1, HPSE, ACTC1
30creatinine4510.3NPHS1, NPHS2, TF, HPSE, ACTC1, ALB
31paraffin4510.2TF, NEU1, HBEGF, IL10, ACTC1
32n-acetylglucosamine4510.2HPSE, NEU1, GNPDA1
33fibrinogen4510.2APOA2, TF, HBEGF, SERPINF2, ALB
34zidovudine45 1111.2NEU1, IL10, ALB
35cyclosporin a45 29 6012.2NPHS2, GALNS, TF, IL13, IL10, ACTC1
36steroid4510.2NPHS1, NPHS2, HPSE, IL13, ACTC1, ALDH3A2
37glutamine4510.2SERPINF2, IL13, TFAM, TF, APOA2
38heparin45 29 11 2413.2LAMB2, IL13, HBEGF, NEU1, GALNS, APOA2
39polyethylene glycol4510.2ALB, NEU1, TF
40biotin45 11 2412.1ACTC1, IL10, TF
41serine4510.1APOA2, NPHS1, GALNS, NEU1, IL13, ACTN4
42polysaccharide4510.1GALNS, TF, NEU1, HBEGF, HPSE, IL13
43alanine4510.1TF, HBEGF, HPSE, IL13, SERPINF2, ALB
44alpha tocopherol4510.0TF, IL13, ALB
45vegf4510.0NPHS1, TF, HBEGF, HPSE, IL13, IL10
46lipid4510.0APOA2, NPHS1, NPHS2, HBEGF, HPSE, SERPINF2
47mip 1alpha4510.0IL10, IL13
48retinoic acid45 2410.9APOA2, NPHS1, NEU1, HBEGF, IL13, ACTC1
49calcium45 50 11 2412.4TFAM, GALNS, NPHS2, NPHS1, GNPDA1, HBEGF

GO Terms for genes affiliated with Nephrosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:03605710.2NPHS2, NPHS1
2platelet alpha granule lumenGO:03109310.1ACTN4, SERPINF2, ALB
3extracellular vesicular exosomeGO:07006210.1ALB, ACTN4, ACTC1
4lysosomal lumenGO:0432029.8HPSE, NEU1, GALNS
5extracellular regionGO:0055769.6ALB, SERPINF2, ACTN4, IL13, HPSE, HBEGF

Biological processes related to Nephrosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular visceral epithelial cell developmentGO:07224910.3LAMB2, NPHS2
2platelet degranulationGO:00257610.1ALB, SERPINF2, ACTN4, TF
3platelet activationGO:03016810.0ALB, SERPINF2, ACTN4, TF
4positive regulation of smooth muscle cell proliferationGO:04866110.0HBEGF, IL13, SERPINF2
5negative regulation of cytokine secretion involved in immune responseGO:0027409.9IL10, APOA2

Products for genes affiliated with Nephrosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nephrosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet