MCID: NPH012
MIFTS: 57

Nephrotic Syndrome malady

Nephrological category

Summaries for Nephrotic Syndrome

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Nephrotic syndrome is a nonspecific kidney disorder characterised by a number of signs of disease:... more...

MalaCards: Nephrotic Syndrome is related to focal segmental glomerulosclerosis and amyloidosis. An important gene associated with Nephrotic Syndrome is NPHS2 (nephrosis 2, idiopathic, steroid-resistant (podocin)), and among its related pathways are Rho Family GTPases and Cell-cell junction organization. The drugs cyclophosphamide and bendroflumethiazide and the compounds calcium and creatinine have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Nephrotic Syndrome

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 35MeSH, 27ICD9CM, 57SNOMED-CT, 40NCIt, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological


Aliases & Descriptions:

nephrotic syndrome 8 10 45 61


External Ids:

Disease Ontology8 DOID:1184
MeSH35 D009404
ICD9CM27 581
NCIt40 C34845
ICD1025 N04, N04.9

Related Diseases for Nephrotic Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the nephrotic syndrome, type 7 family:

familial nephrotic syndrome nephrotic syndrome
nephrotic syndrome type 3 nephrotic syndrome, type 5, with or without ocular abnormalities
nephrotic syndrome, type 2 nephrotic syndrome, type 4
nephrotic syndrome, type 6 nephrotic syndrome, type 8
nephrotic syndrome, type 9 nephrotic syndrome, type 1

Diseases related to Nephrotic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 433)
idRelated DiseaseScoreTop Affiliating Genes
1focal segmental glomerulosclerosis31.1PLCE1, SMARCAL1
2amyloidosis30.9F9, CD79A, ALB
3membranous glomerulonephritis30.8CD79A, NPHS2, NPHS1, CD2AP, ALB
4nephritis30.8ALB, CD79A, MPV17, NPHS1, NPHS2
5lipoid nephrosis30.7IL4R, IL13, NAGLU, CD2AP, CD79A, TF
6diffuse mesangial sclerosis30.7NPHS1, WT1, NPHS2
7nephrosis30.6ACTN4, LAMB2, NPHS1, NPHS2
8membranoproliferative glomerulonephritis30.4NPHS1, CD79A
9arthritis30.4IL13, ALB
10nail-patella syndrome30.3LMX1B, NPHS2, CD2AP
11thromboembolism30.3F9
12wilms tumor30.3CD2AP, ACTN4, NPHS2, NPHS1, WT1
13denys-drash syndrome30.3WT1
14thyroiditis30.3CD79A
15lupus nephritis30.2ALB, NAGLU, CD79A
16hypercholesterolemia30.2PPBP, F9
17atherosclerosis30.2ALB, PPBP
18diabetic nephropathy30.0ALB, NAGLU, TF, NPHS1, NPHS2
19tuberculosis30.0IL4R, CD79A, ALB
20frasier syndrome30.0WT1
21thrombocytopenia29.8PPBP, F9, ALB, CD79A
22graves' disease29.8IL13, IL4R
23cystic fibrosis29.8ALB, F9
24thalassemia29.8TF
25bronchitis29.8CD79A
26acquired immunodeficiency syndrome29.8ALB
27crohn's disease29.8ALB
28thrombocytosis29.8PPBP
29n syndrome11.5
30steroid-resistant nephrotic syndrome11.1
31adult syndrome10.8
32focal glomerulosclerosis10.7
33kid syndrome10.7
34congenital nephrotic syndrome finnish type10.7
35familial nephrotic syndrome10.7
36micro syndrome10.6
37nephrotic syndrome, idiopathic, steroid-resistant10.5
38syphilis10.5
39char syndrome10.4
40proliferative glomerulonephritis10.4
41idiopathic steroid-sensitive nephrotic syndrome10.4
42young syndrome10.4
43microcephaly, hiatal hernia and nephrotic syndrome10.4
44pierson syndrome10.4
45nephrotic syndrome, type 110.4
46hepatitis c10.4
47amyloidosis, renal10.4
48strongyloidiasis10.3
49secondary syphilis10.3
50hepatitis a10.3

Graphical network of the top 20 diseases related to Nephrotic Syndrome:



Diseases related to nephrotic syndrome

Clinical Features for Nephrotic Syndrome

Drugs & Therapeutics for Nephrotic Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Nephrotic Syndrome

Anatomical Context for Nephrotic Syndrome

Animal Models for Nephrotic Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Nephrotic Syndrome

Sources:
51PubMed
See all sources

Articles related to Nephrotic Syndrome:

(show top 50)    (show all 1620)
idTitleAuthorsYear
1
Short- and long-term efficacy of levamisole in children with steroid-sensitive nephrotic syndrome. (22826143)
2013
2
Pulmonary congestion due to hypothyroidism and nephrotic syndrome induced by cold agglutinins. (23934232)
2013
3
Steroid-resistant nephrotic syndrome: impact of genetic testing. (24413855)
2013
4
Prediction of steroid-sparing agent use in childhood idiopathic nephrotic syndrome. (23179197)
2013
5
Tocilizumab treatment for nephrotic syndrome due to amyloidosis in Behcet's disease. (23472940)
2013
6
Outcomes of tacrolimus therapy in adults with refractory membranous nephrotic syndrome: a prospective, multicenter clinical trial. (22627258)
2013
7
Thrombosis in nephrotic syndrome. (23625754)
2013
8
Is There a Role for Mammalian Target of Rapamycin Inhibition in Renal Failure due to Mesangioproliferative Nephrotic Syndrome? (22685654)
2012
9
WaldenstrAPm's macroglobulinaemia presenting with nephrotic syndrome. (23123536)
2012
10
Abdominal pain, arthritis, and nephrotic syndrome in a Syrian patient. (22760913)
2012
11
Rituximab in children with resistant idiopathic nephrotic syndrome. (22581994)
2012
12
Serum albumin level accurately reflects antioxidant potentials in idiopathic nephrotic syndrome. (22203175)
2012
13
Nephrotic Syndrome Following H1N1 Influenza in a 3-Year-Old Boy. (23056898)
2012
14
The plasma permeability factor in nephrotic syndrome: indirect evidence in pediatric peritoneal dialysis. (22473035)
2012
15
Cyclosporine treatment in idiopathic membranous nephropathy nephrotic syndrome in adults: a retrospective study spanning 15 years. (22340164)
2011
16
Congenital nephrotic syndrome. (22299306)
2011
17
Nephrotic syndrome with atherosclerosis. (22711151)
2011
18
WaldenstrAPm's macroglobulinemia and nephrotic syndrome with membranous nephropathy. (21612326)
2011
19
Management and outcome of steroid-resistant nephrotic syndrome in children. (19841524)
2009
20
Management of steroid resistant nephrotic syndrome. (19179716)
2009
21
Low prevalence of NPHS2 mutations in African American children with steroid-resistant nephrotic syndrome. (18543005)
2008
22
Mycophenolate mofetil treatment in primary glomerular disease: one-year follow-up in steroid dependent and resistant nephrotic syndrome. (17044475)
2006
23
Steroidogenic impairment due to reduced ovarian transcription of cytochrome P450 side-chain-cleavage (P450scc) and steroidogenic acute regulatory protein (StAR) during experimental nephrotic syndrome. (16574160)
2006
24
ACE gene polymorphism in children with nephrotic syndrome in the Indonesian population. (16421456)
2005
25
Nephrotic syndrome and situs inversus viscerum: correlation or coincidence. (16299692)
2005
26
Nephrotic syndrome with extensive mesangiolysis as a clinical manifestation of chronic graft-versus-host disease (GVHD). (16207604)
2005
27
Late onset of familial nephrotic syndrome associated with a compound heterozygous mutation of the podocin-encoding gene. (16354237)
2005
28
Analysis of NPHS1, NPHS2, ACTN4, and WT1 in Japanese patients with congenital nephrotic syndrome. (15780077)
2005
29
Management of edema in nephrotic syndrome. (15347866)
2004
30
Short term efficacy of intravenous dexamethasone and methylprednisolone therapy in steroid resistant nephrotic syndrome. (15523124)
2004
31
Glomerular permeability activity: prevalence and prognostic value in pediatric patients with idiopathic nephrotic syndrome. (15384010)
2004
32
Expression of nephrin, podocin, alpha-actinin, and WT1 in children with nephrotic syndrome. (12961083)
2003
33
Congenital nephrotic syndrome. (17657104)
2003
34
Steroid resistant nephrotic syndrome. (12557961)
2002
35
Congenital nephrotic syndrome of the Finnish type in Italy: a molecular approach. (12495287)
2002
36
Steroid responsive nephrotic syndrome associated with bilateral renal dysplasia. (11420919)
2001
37
Does the changed Th1/Th2 activity in children with the assessment of body water in children with nephrotic syndrome: initial results]. (10897620)
2000
38
Influence of serum albumin on renal function in nephrotic syndrome. (10100284)
1999
39
Discovery of the congenital nephrotic syndrome gene discloses the structure of the mysterious molecular sieve of the kidney. (10535322)
1999
40
Resolution of HIV-associated nephrotic syndrome with highly active antiretroviral therapy delivered by gastrostomy tube. (10585995)
1999
41
Mycosis fungoides with focal segmental glomerular sclerosis and nephrotic syndrome. (9486702)
1998
42
Role of lipoprotein-bound NEFAs in enhancing the specific activity of plasma CETP in the nephrotic syndrome. (9409228)
1997
43
Steroid resistant nephrotic syndrome associated with spondyloepiphyseal dysplasia, transient ischemic attacks and lymphopenia. (7736684)
1995
44
The prolonged thrombin time of nephrotic syndrome. (7749766)
1995
45
Iso-oncotic volume expansion in the nephrotic syndrome. (8334809)
1993
46
Role of renal insufficiency in altered erythropoietin metabolism in the nephrotic syndrome. (1524095)
1992
47
Atrial natriuretic factor in idiopathic minimal-lesion nephrotic syndrome. (2147579)
1990
48
Nephrotic syndrome and secondary syphilis. (1175490)
1975
49
Cold agglutinin disease and the nephrotic syndrome. (5467157)
1970
50
Immunosuppressive therapy in steroid-resistant proliferative glomerulonephritis accompanied by the nephrotic syndrome. (5917404)
1966

Genetic Variations for Nephrotic Syndrome

Expression for genes affiliated with Nephrotic Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Nephrotic Syndrome

Search GEO for disease gene expression data for Nephrotic Syndrome.

Pathways for genes affiliated with Nephrotic Syndrome

Sources:
52QIAGEN, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems
See all sources

Compounds for genes affiliated with Nephrotic Syndrome

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Nephrotic Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2414.7ACTN4, PLCE1, LAMB2, ALB, NAGLU, PPBP
2creatinine4511.7CD79A, NAGLU, PPBP, F9, WT1, NPHS1
3steroid4511.7CD79A, NPHS1, CD2AP, NAGLU, LMX1B, WT1
4tyrosine4511.6F9, WT1, ACTN4, NPHS1, NPHS2, PPBP
5cyclosporin a45 29 6013.6F9, IL13, WT1, NPHS2, TF, CD79A
6alanine4511.5PPBP, F9, ALB, CD79A, IL13, TF
7cysteine4511.4ALB, PPBP, F9, IL13, NAGLU, CD79A
8citrate4511.4PPBP, NAGLU, ALB, TF, F9, CD79A
9hyaluronic acid45 2412.4CD79A, WT1, PPBP, NAGLU, IL13, ALB
10heparin45 29 11 2414.4LAMB2, IL13, NAGLU, PPBP, CD79A, F9
11histamine45 29 2413.4IL4R, IL13, TF, CD79A, PPBP, ALB
12lactate4511.4ALB, PPBP, TF, IL13, CD79A, NAGLU
13thymidine45 2412.4IL13, NAGLU, PPBP, WT1, IL4R, F9
14prednisolone45 29 1113.3ALB, F9, TF, CD79A, IL13
15lipid4511.3NPHS1, PPBP, CD2AP, NAGLU, F9, NPHS2
16tacrolimus45 50 1113.3TF, CD79A, NAGLU, IL13, ALB
17dexamethasone45 50 29 1114.3NPHS1, PPBP, CD79A, IL4R, F9, IL13
18vegf4511.3PPBP, WT1, IL13, CD79A, TF, NPHS1
19fibrinogen4511.3F9, ALB, CD79A, TF, PPBP
20penicillin4511.2PPBP, TF, CD79A, IL13
21glutamine4511.2WT1, TF, F9, IL13, IL4R
22sialic acid4511.2TF, CD79A, NAGLU, F9
23puromycin aminonucleoside4511.2CD2AP, NPHS2, NPHS1
24thyroxine45 2412.2IL13, CD79A, ALB, TF
25cyclophosphamide45 50 1113.2NAGLU, TF, NPHS2
26iohexol4511.1PPBP, ALB, NAGLU
27warfarin45 50 11 2414.1F9, CD79A, PPBP
28silicone4511.1F9, CD79A, PPBP
29glutaraldehyde4511.1TF, CD79A, ALB
30methotrexate45 50 1113.1CD79A, TF, ALB, NAGLU
31desmopressin45 60 29 1114.1F9, PPBP, NAGLU
32Bismuth Subsalicylate1111.0ALB, TF
33diclofenac45 29 50 1114.0NAGLU, ALB, IL13
34iodixanol4511.0PPBP, NAGLU
35kp-10194511.0TF, ALB
36ivig4511.0CD79A, ALB, F9
37iopentol4511.0NAGLU, ALB
38p-aminohippuric acid4511.0NAGLU, ALB
39vitamin b124510.9TF, ALB, CD79A
40aluminium45 1111.9NAGLU, TF
41aspartate4510.9NAGLU, ALB
42vitamin a45 11 2412.9NAGLU
43rituximab45 50 1112.8CD79A, F9, IL13
44tween 804510.8F9, ALB
45bismuth45 2411.8ALB, TF
46allergens4510.8IL4R, CD79A, IL13
47inulin4510.6ALB, NAGLU
48ovomucoid4510.6TF
49gelfoam4510.5ALB, TF
50indomethacin45 60 29 1113.5NPHS1, CD79A, IL13, ALB

GO Terms for genes affiliated with Nephrotic Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Nephrotic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:03605710.6NPHS2, NPHS1
2platelet alpha granule lumenGO:03109310.4ALB, ACTN4, PPBP

Biological processes related to Nephrotic Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:00257611.0ALB, ACTN4, TF, PPBP
2glomerular basement membrane developmentGO:03283610.9WT1, NPHS1, MPV17
3platelet activationGO:03016810.8ALB, ACTN4, TF, PPBP
4excretionGO:00758810.8KIRREL, NPHS2, NPHS1
5blood coagulationGO:00759610.8ALB, TF, ACTN4, F9, PPBP
6metanephric glomerular visceral epithelial cell developmentGO:07224910.8LAMB2, NPHS2
7positive regulation of macrophage activationGO:04303210.6IL4R, IL13
8glomerulus developmentGO:03283510.3PLCE1, WT1

Products for genes affiliated with Nephrotic Syndrome

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  • Lysates
  • Antibodies

Sources for Nephrotic Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet