MCID: NPH012
MIFTS: 59

Nephrotic Syndrome malady

Categories: Nephrological diseases, Genetic diseases, Blood diseases, Rare diseases, Immune diseases

Aliases & Classifications for Nephrotic Syndrome

Aliases & Descriptions for Nephrotic Syndrome:

Name: Nephrotic Syndrome 12 29 52 42 14 69
Finnish Congenital Nephrotic Syndrome 69
Finnish Congenital Nephrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1184
ICD10 33 N04 N04.9
ICD9CM 35 581
MeSH 42 D009404
NCIt 47 C34845
UMLS 69 C0027726

Summaries for Nephrotic Syndrome

MalaCards based summary : Nephrotic Syndrome, also known as finnish congenital nephrotic syndrome, is related to familial nephrotic syndrome and focal segmental glomerulosclerosis, and has symptoms including edema An important gene associated with Nephrotic Syndrome is NPHS2 (NPHS2, Podocin), and among its related pathways/superpathways are Hexose transport and Primary Focal Segmental Glomerulosclerosis FSGS. The drugs Cyclosporine and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and heart, and related phenotypes are homeostasis/metabolism and mortality/aging

Wikipedia : 71 Nephrotic syndrome is a syndrome comprising signs of nephrosis, chiefly protein in the urine, low blood... more...

Related Diseases for Nephrotic Syndrome

Diseases in the Nephrotic Syndrome family:

Nephrotic Syndrome, Type 2 Nephrotic Syndrome, Type 3
Nephrotic Syndrome, Type 4 Nephrotic Syndrome, Type 6
Nephrotic Syndrome, Type 10 Nephrotic Syndrome, Type 7
Nephrotic Syndrome, Type 8 Nephrotic Syndrome, Type 9
Nephrotic Syndrome, Type 1 Familial Nephrotic Syndrome
Hereditary Nephrotic Syndromes Hereditary Nephrotic Syndromes, Autosomal Dominant
Hereditary Nephrotic Syndromes, Autosomal Recessive Nephrotic Syndrome Type 11
Nephrotic Syndrome Type 12 Nephrotic Syndrome Type 13
Nephrotic Syndrome, Kank4-Related

Diseases related to Nephrotic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 449)
id Related Disease Score Top Affiliating Genes
1 familial nephrotic syndrome 32.9 ALB CD79A NPHS1 NPHS2 WT1
2 focal segmental glomerulosclerosis 32.6 ACTN4 CD2AP ITGA3 LAMB2 NPHS1 NPHS2
3 frasier syndrome 31.9 CD2AP NPHS1 NPHS2 WT1
4 nephrotic syndrome, type 1 12.3
5 nephrotic syndrome, type 5, with or without ocular abnormalities 12.2
6 nephrotic syndrome, type 3 12.2
7 congenital nephrotic syndrome finnish type 12.2
8 nephrotic syndrome, type 7 12.1
9 nephrotic syndrome, type 6 12.1
10 nephrotic syndrome, type 4 12.1
11 interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital 12.1
12 nephrotic syndrome, type 2 12.1
13 nephrotic syndrome, type 9 12.1
14 nephrotic syndrome, type 8 12.1
15 nephrotic syndrome, type 10 12.0
16 nephrotic syndrome type 11 12.0
17 nephrotic syndrome type 12 12.0
18 nephrotic syndrome type 13 12.0
19 pierson syndrome 11.9
20 lipoid nephrosis 11.9
21 familial idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis 11.8
22 idiopathic steroid-sensitive nephrotic syndrome with focal segmental hyalinosis 11.8
23 sporadic idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis 11.8
24 hereditary nephrotic syndromes 11.8
25 galloway-mowat syndrome 11.8
26 nephrotic syndrome, idiopathic, steroid-resistant 11.8
27 steroid-resistant nephrotic syndrome, nphs2-related 11.8
28 sporadic idiopathic steroid-resistant nephrotic syndrome with collapsing glomerulopathy 11.8
29 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 11.8
30 sporadic idiopathic steroid-resistant nephrotic syndrome with minimal changes 11.8
31 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis 11.8
32 familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis 11.8
33 familial idiopathic steroid-resistant nephrotic syndrome with minimal changes 11.8
34 familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 11.8
35 idiopathic steroid-sensitive nephrotic syndrome with minimal change 11.8
36 idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation 11.8
37 nephrotic syndrome ocular anomalies 11.7
38 leigh syndrome with nephrotic syndrome 11.7
39 hereditary nephrotic syndromes, autosomal dominant 11.7
40 hereditary nephrotic syndromes, autosomal recessive 11.7
41 nephrotic syndrome, kank4-related 11.7
42 coenzyme q10 deficiency, primary, 6 11.7
43 steroid-resistant nephrotic syndrome, xpo5-related 11.6
44 glomerulosclerosis, focal segmental, 4 11.6
45 glomerulosclerosis, focal segmental, 1 11.4
46 membranous nephropathy 11.3
47 glomerulosclerosis, focal segmental, 6 11.3
48 denys-drash syndrome 11.3
49 glomerulosclerosis, focal segmental, 7 11.2
50 glomerulosclerosis, focal segmental, 2 11.2

Graphical network of the top 20 diseases related to Nephrotic Syndrome:



Diseases related to Nephrotic Syndrome

Symptoms & Phenotypes for Nephrotic Syndrome

UMLS symptoms related to Nephrotic Syndrome:


edema

MGI Mouse Phenotypes related to Nephrotic Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 ACTN4 ALB ARHGDIA CD2AP CD79A ITGA3
2 mortality/aging MP:0010768 9.73 NPHS2 SERPINC1 WT1 ACTN4 ALB ARHGDIA
3 renal/urinary system MP:0005367 9.44 KIRREL LAMB2 NPHS1 NPHS2 SERPINC1 SYNPO

Drugs & Therapeutics for Nephrotic Syndrome

Drugs for Nephrotic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 192)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 2 79217-60-0, 59865-13-3 5284373 6435893
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
3
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3 128794-94-5 5281078
4
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
6
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
7
Cosyntropin Approved Phase 4 16960-16-0 16129617
8
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
9
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
10
rituximab Approved Phase 4,Phase 2,Phase 3 174722-31-7 10201696
11
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
12
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
13
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
14
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
15
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
16
Pravastatin Approved Phase 4,Phase 1 81093-37-0 54687
17
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
18
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 11103-57-4, 68-26-8 445354
19
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
20
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
21
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
22 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
23 Methylprednisolone acetate Phase 4,Phase 3,Phase 2
24 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2
25 Prednisolone acetate Phase 4,Phase 3,Phase 2
26 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2
27 Prednisolone phosphate Phase 4,Phase 3,Phase 2
28 Vaccines Phase 4
29 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
30 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
31 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
33 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
34 glucocorticoids Phase 4,Phase 3,Phase 2
35 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
36 Hormones Phase 4,Phase 3,Phase 2,Phase 1
37 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
38 Antiemetics Phase 4,Phase 3,Phase 2
39 Autonomic Agents Phase 4,Phase 3,Phase 2
40 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
41 Neuroprotective Agents Phase 4,Phase 3
42 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
43 Protective Agents Phase 4,Phase 3
44 Cortisol succinate Phase 4
45 Epinephryl borate Phase 4,Phase 2
46 Hydrocortisone 17-butyrate 21-propionate Phase 4
47 Hydrocortisone acetate Phase 4
48 Racepinephrine Phase 4,Phase 2
49 Antirheumatic Agents Phase 4,Phase 2,Phase 3,Phase 1
50 Calcineurin Inhibitors Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 111)
id Name Status NCT ID Phase
1 Study of 7-valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome Unknown status NCT01346007 Phase 4
2 Mycophenolate Mofetil in Pediatric Steroid Dependent Nephrotic Syndrome Unknown status NCT01895894 Phase 4
3 Low Dose Steroids in the Treatment of Nephrotic Syndrome Relapse Unknown status NCT02216747 Phase 4
4 Long Term Tapering or Standard Steroids for Nephrotic Syndrome Unknown status NCT00308321 Phase 4
5 Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test Unknown status NCT00851942 Phase 4
6 Therapeutic Effect of Tacrolimus on Primary Nephrotic Syndrome in Children Completed NCT01162005 Phase 4
7 Treatment of Resistant Nephrotic Syndrome With ACTH Gel (ACTHAR) Completed NCT01129284 Phase 4
8 Urinary Aquaporin 2 and Expression of the NPHS2 Gene in Adults Suffering From Nephrotic Syndrome Completed NCT00286910 Phase 4
9 Prospective Study Evaluating the Effect of Repository Corticotropin in the Treatment of Various Nephrotic Syndromes Completed NCT01021540 Phase 4
10 Role of Acetazolamide and Hydrochlorothiazide Followed by Furosemide in Treating Nephrotic Edema Completed NCT02427880 Phase 4
11 Acthar for Treatment of Proteinuria in Membranous Nephropathy Patients Completed NCT01386554 Phase 4
12 Adrenocorticotropic Hormone (ACTH) Treatment of Nephrotic Range Proteinuria in Diabetic Nephropathy (NRDN) Completed NCT01028287 Phase 4
13 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4
14 Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Resistant Nephrotic Syndrome Recruiting NCT02382575 Phase 4
15 Myfortic® for Minimal Change Nephrotic Syndrome (MCNS): a Randomized Study Recruiting NCT01185197 Phase 4
16 Tacrolimus Versus Prednisolone for the Treatment of Minimal Change Disease Recruiting NCT00982072 Phase 4
17 Tacrolimus Combined With Entecavir on HBV Associated Glomerulonephritis(HBV-GN) Recruiting NCT03062813 Phase 4
18 Efficacy of Usual Vitamin D Supplementation and Its Impact on Children and Adolescents Calciuria. Recruiting NCT02238418 Phase 4
19 Mycophenolate Mofetil Plus Steroid in the Treatment Of Patients With Progressive Idiopathic Membranous Nephropathy Recruiting NCT03170323 Phase 4
20 ACTHAR GEL in Patients With Membranous (Class V) Lupus Nephritis Recruiting NCT01926054 Phase 4
21 A Study to Evaluate the Effect of Tacrolimus and Corticosteroid Combination Therapy in Patients With Minimal Change Nephrotic Syndrome Active, not recruiting NCT01763580 Phase 4
22 Mycophenolate Mofetil and Tacrolimus Versus Tacrolimus for the Treatment of Idiopathic Membranous Glomerulonephritis (IMG) Active, not recruiting NCT00843856 Phase 4
23 Adjusted Steroids Therapy in Childerens With Idiopathic Nephrotic Syndrome Not yet recruiting NCT02649413 Phase 4
24 Anti-Oxidant Therapy In Chronic Renal Insufficiency (ATIC) Study Terminated NCT00384618 Phase 4
25 Rituximab Trial for Pediatric Nephrotic Syndrome Unknown status NCT01716442 Phase 2, Phase 3
26 Efficacy of Pentoxifylline on Primary Nephrotic Syndrome Completed NCT00354731 Phase 3
27 Efficacy of Rituximab For the Treatment of Calcineurin Inhibitors Dependent Nephrotic Syndrome During Childhood Completed NCT01268033 Phase 2, Phase 3
28 Cyclophosphamide Versus Mycophenolate Mofetil for the Treatment of Steroid-dependent Nephrotic Syndrome in Children Completed NCT01092962 Phase 3
29 Evaluation of Low Dose Corticosteroids Efficiency, Associated With Myfortic ® in the Treatment of Nephrotic Syndrome Completed NCT01197040 Phase 3
30 Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Dependent Nephrotic Syndrome Completed NCT02438982 Phase 3
31 The Efficacy and Tolerance of Tacrolimus Sustained-release Capsules on Refractory Nephrotic Syndrome (RNS) Completed NCT01309477 Phase 3
32 Tacrolimus Combined With Prednisone Treatment of Idiopathic Membranous Nephropathy and Nephrotic Syndrome Completed NCT00362531 Phase 2, Phase 3
33 Prospective, Multicenter Study of the Efficacy and Tolerance of Tacrolimus on Refractory Nephrotic Syndrome (RNS) Completed NCT00615667 Phase 3
34 Rituximab in Multirelapsing Minimal Change Disease (MCD) or Focal Segmental Glomerulosclerosis (FSGS) Completed NCT00981838 Phase 3
35 Steroid Treatment for Kidney Disease Completed NCT00065611 Phase 3
36 Study of the Safety and Efficacy of NC-503 in Secondary (AA) Amyloidosis Completed NCT00035334 Phase 2, Phase 3
37 Rituximab in Membranous Nephropathy Completed NCT00425217 Phase 2, Phase 3
38 Therapeutic Effect of Tacrolimus in Combination With Low Dose Corticosteroid in Adult Patient With Minimal Change Nephritic Syndrome Completed NCT01084980 Phase 2, Phase 3
39 Adrenocorticotropic Hormone (ACTH) for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome Recruiting NCT02132195 Phase 3
40 A Study to Evaluate the Efficacy and Safety of Mizoribine in the Treatment of Refractory Nephrotic Syndrome Recruiting NCT02257697 Phase 3
41 Prednisolone Trial in Children Younger Than 4 Years Recruiting NCT03141970 Phase 3
42 Rituximab Versus Steroids and Cyclophosphamide in the Treatment of Idiopathic Membranous Nephropathy Recruiting NCT03018535 Phase 3
43 Evaluate Rituximab Treatment for Idiopathic Membranous Nephropathy Active, not recruiting NCT01508468 Phase 3
44 Efficiency of Levamisole for Maintaining Remission After the First Flare of Steroid Sensitive Nephrotic Syndrome in Children Not yet recruiting NCT02818738 Phase 3
45 Valproic Acid for Idiopathic Nephrotic Syndrome Not yet recruiting NCT02896270 Phase 2, Phase 3
46 Randomized Trial Comparing Rituximab Against Mycophenolate Mofetil in Children Wtih Refractory Nephrotic Syndrome Terminated NCT02390362 Phase 3
47 IL-2 for Multi Drug Resistant Nephrotic Syndrome Completed NCT02455908 Phase 1, Phase 2
48 Drug Therapy in Lupus Nephropathy Completed NCT00001212 Phase 2
49 Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis Completed NCT00004990 Phase 2
50 Pirfenidone to Treat Kidney Disease (Focal Segmental Glomerulosclerosis) Completed NCT00001959 Phase 2

Search NIH Clinical Center for Nephrotic Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: nephrotic syndrome

Genetic Tests for Nephrotic Syndrome

Genetic tests related to Nephrotic Syndrome:

id Genetic test Affiliating Genes
1 Nephrotic Syndrome 29

Anatomical Context for Nephrotic Syndrome

MalaCards organs/tissues related to Nephrotic Syndrome:

39
Kidney, Lung, Heart, T Cells, Testes, Endothelial, Thyroid

Publications for Nephrotic Syndrome

Articles related to Nephrotic Syndrome:

(show top 50) (show all 1887)
id Title Authors Year
1
A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome. ( 28164240 )
2017
2
Multidimensional impact on families of children with steroid-sensitive nephrotic syndrome. ( 28058746 )
2017
3
Cryptococcosis in Patients with Nephrotic Syndrome: A Pooled Analysis of Cases. ( 28054218 )
2017
4
Further phenotypic heterogeneity of CoQ10 deficiency associated with Steroid Resistant Nephrotic Syndrome and novel COQ2 and COQ6 variants. ( 28044327 )
2017
5
Diabetes and nephrotic syndrome: Questions. ( 28074283 )
2017
6
Fibroblast Growth Factor 23 (FGF23) in untreated Nephrotic syndrome. ( 28087977 )
2017
7
Biochemical alteration in children with idiopathic nephrotic syndrome associated with an increased risk of sensorineural hearing loss; additional insights in cochlear renal relationship. ( 28483237 )
2017
8
Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy with Nephrotic Syndrome. ( 28090051 )
2017
9
The Clinical Course of Minimal Change Nephrotic Syndrome With Onset in Adulthood or Late Adolescence: A Case Series. ( 28089478 )
2017
10
Cytoplasmic Localization of WT1 and Decrease of miRNA-16-1 in Nephrotic Syndrome. ( 28299339 )
2017
11
Glomerular Glucocorticoid Receptors Expression and Clinicopathological Types of Childhood Nephrotic Syndrome. ( 27690709 )
2017
12
Nephrotic syndrome associated with metastatic thymoma treated with chemotherapy. ( 28072685 )
2017
13
Steroid-resistant nephrotic syndrome as the initial presentation of nail-patella syndrome: a case of a de novo LMX1B mutation. ( 28335748 )
2017
14
Screening of WT1 mutations in exon 8 and 9 in children with steroid resistant nephrotic syndrome from a single centre and establishment of a rapid screening assay using high-resolution melting analysis in a clinical setting. ( 28068926 )
2017
15
Nephrotic Syndrome in Small Cell Lung Cancer and Induction of C-Mip in Podocytes. ( 28063735 )
2017
16
Elevation of plasma-soluble HLA-G in childhood nephrotic syndrome is associated with IgE. ( 27126267 )
2016
17
Interventions for idiopathic steroid-resistant nephrotic syndrome in children. ( 27726125 )
2016
18
Primary Cutaneous Nocardiosis in a Patient With Nephrotic Syndrome: A Case Report and Review of the Literature. ( 26817885 )
2016
19
Congenital nephrotic syndrome with a novel NPHS1 mutation. ( 27882743 )
2016
20
Cerebral venous thrombosis and secondary polycythemia in a case of nephrotic syndrome. ( 26997397 )
2016
21
Cholecystitis and nephrotic syndrome complicating Epstein-Barr virus primary infection. ( 27077634 )
2016
22
Patterns of Childhood Steroid-Sensitive and Steroid-Resistant Nephrotic Syndrome in Saudi Children: Clinicopathological Study of 87 Cases. ( 27130200 )
2016
23
Mutations in WT1 in boys with sporadic isolated steroid-resistant nephrotic syndrome. ( 26985958 )
2016
24
Case of yellow nail syndrome accompanied by nephrotic syndrome. ( 26704457 )
2016
25
Minimal change nephrotic syndrome showing complete remission after resection of a neurofibroma in a type I neurofibromatosis patient. ( 26951918 )
2016
26
Proteomics Approach Identifies Factors Associated With the Response to Low-Density Lipoprotein Apheresis Therapy in Patients With Steroid-Resistant Nephrotic Syndrome. ( 26771065 )
2016
27
Risk of Nephrotic Syndrome following Enteroviral Infection in Children: A Nationwide Retrospective Cohort Study. ( 27508414 )
2016
28
Erratum to: Steroid-resistant nephrotic syndrome in a child with dysmorphic features: Answers. ( 26820663 )
2016
29
High incidence of idiopathic nephrotic syndrome in East Asian children: a nationwide survey in Japan (JP-SHINE study). ( 27590892 )
2016
30
Population Pharmacokinetics of Prednisolone in Relation to Clinical Outcome in Children with Nephrotic Syndrome. ( 27120177 )
2016
31
Vitamin D receptor gene TaqI and Apal polymorphisms and steroid responsiveness in childhood idiopathic nephrotic syndrome. ( 27540309 )
2016
32
Ethnic Differences in Childhood Nephrotic Syndrome. ( 27148508 )
2016
33
Nephrotic syndrome and situs inversus--A chance association? ( 26787592 )
2016
34
Eosinophilic gastroenteritis in an 18-year-old male with prolonged nephrotic syndrome. ( 28018451 )
2016
35
Posterior Reversible Encephalopathy Syndrome With Concurrent Nephrotic Syndrome in a Patient Treated With Pazopanib for Metastatic Renal Cell Carcinoma: Case Report and Review of the Literature. ( 27601362 )
2016
36
A rare case of phaeohyphomycosis caused by Fonsecaea pedrosoi in a child with nephrotic syndrome. ( 27194840 )
2016
37
Antithrombotic prophylaxis in a patient with nephrotic syndrome and congenital protein S deficiency. ( 26928822 )
2016
38
Long-term outcome of idiopathic steroid-resistant nephrotic syndrome in children: response to comments. ( 26628279 )
2016
39
Paraoxonase Activity and Lipid Profile in Paediatric Nephrotic Syndrome: A Cross-sectional Study. ( 27134858 )
2016
40
Successful Preemptive Kidney Transplantation With Rituximab Induction in a Patient With Focal Segmental Glomerulosclerosis and Massive Nephrotic Syndrome: A Case Report. ( 27932154 )
2016
41
Comparison of Efficacy of Tacrolimus Versus Cyclosporine in Childhood Steroid-Resistant Nephrotic Syndrome. ( 27504551 )
2016
42
Nephrotic syndrome as a complication of chronic graft-versus-host disease after allogeneic haemopoietic stem cell transplantation. ( 27257151 )
2016
43
Perirenal mass with nephrotic syndrome caused by WaldenstrAPm macroglobulinaemia. ( 27619105 )
2016
44
Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome. ( 26878725 )
2016
45
Pioglitazone Enhances the Beneficial Effects of Glucocorticoids in Experimental Nephrotic Syndrome. ( 27142691 )
2016
46
Cyclical cyclophosphamide and steroids is effective inA resistant or relapsing nephrotic syndrome due toA M-type phospholipase A2A receptor-related membranous nephropathy after tacrolimus therapy. ( 27181781 )
2016
47
Disorders of lipid metabolism in nephrotic syndrome: mechanisms and consequences. ( 27165836 )
2016
48
WT1 mutations in steroid-resistant idiopathic nephrotic syndrome. ( 26997404 )
2016
49
Children with Steroid-resistant Nephrotic Syndrome: Long-term Outcomes of Sequential Steroid Therapy. ( 27806747 )
2016
50
Influence of the New Cooperative Medical Scheme on hospitalization cost of patients with nephrotic syndrome in rural China. ( 27131854 )
2016

Variations for Nephrotic Syndrome

Expression for Nephrotic Syndrome

Search GEO for disease gene expression data for Nephrotic Syndrome.

Pathways for Nephrotic Syndrome

Pathways related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.43 NUP107 NUP205 NUP93
2 11.15 ACTN4 CD2AP ITGA3 LAMB2 NPHS1 NPHS2
3 10.87 CD2AP KIRREL NPHS1 NPHS2
4 10.6 ACTN4 CD2AP KIRREL NPHS1

GO Terms for Nephrotic Syndrome

Cellular components related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 membrane raft GO:0045121 9.56 CD79A EMP2 KIRREL NPHS2
2 nuclear pore GO:0005643 9.5 NUP107 NUP205 NUP93
3 cell-cell junction GO:0005911 9.26 ACTN4 CD2AP KIRREL NPHS2
4 slit diaphragm GO:0036057 9.16 NPHS1 NPHS2
5 nuclear periphery GO:0034399 8.8 NUP107 NUP205 NUP93
6 extracellular exosome GO:0070062 10.07 ACTN4 ALB ARHGDIA CD2AP ITGA3 KIRREL

Biological processes related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 viral transcription GO:0019083 9.74 NUP107 NUP205 NUP93
2 mRNA transport GO:0051028 9.73 NUP107 NUP205 NUP93
3 mRNA export from nucleus GO:0006406 9.72 NUP107 NUP205 NUP93
4 regulation of gene silencing by miRNA GO:0060964 9.7 NUP107 NUP205 NUP93
5 protein sumoylation GO:0016925 9.69 NUP107 NUP205 NUP93
6 regulation of cellular response to heat GO:1900034 9.67 NUP107 NUP205 NUP93
7 regulation of actin cytoskeleton reorganization GO:2000249 9.58 ARHGDIA CD2AP
8 intracellular transport of virus GO:0075733 9.58 NUP107 NUP205 NUP93
9 ubiquinone biosynthetic process GO:0006744 9.54 COQ6 COQ8B
10 mitotic nuclear envelope disassembly GO:0007077 9.54 NUP107 NUP205 NUP93
11 excretion GO:0007588 9.5 KIRREL NPHS1 NPHS2
12 glomerular basement membrane development GO:0032836 9.48 NPHS1 WT1
13 glomerulus development GO:0032835 9.46 PLCE1 WT1
14 glomerular visceral epithelial cell development GO:0072015 9.43 NPHS1 NUP93
15 tRNA export from nucleus GO:0006409 9.43 NUP107 NUP205 NUP93
16 regulation of glucose transport GO:0010827 9.33 NUP107 NUP205 NUP93
17 metanephric glomerular visceral epithelial cell development GO:0072249 8.96 LAMB2 NPHS2
18 nuclear pore complex assembly GO:0051292 8.8 NUP107 NUP205 NUP93

Molecular functions related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 fatty acid binding GO:0005504 9.32 ALB ARHGDIA
2 myosin binding GO:0017022 9.26 KIRREL NPHS1
3 integrin binding GO:0005178 9.26 ACTN4 EMP2 ITGA3 LAMB2
4 structural constituent of nuclear pore GO:0017056 8.8 NUP107 NUP205 NUP93
5 protein binding GO:0005515 10.09 ACTN4 ALB ARHGDIA CD2AP CD79A EMP2

Sources for Nephrotic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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