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Nephrotic Syndrome malady
20 drugs, 245 genes, 12 tissues, 1042 related diseases, 26 phenotypes, 580 articles, clinical trials.

Summaries for Nephrotic Syndrome

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44Wikipedia, 22MalaCards
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Wikipedia: Nephrotic syndrome is a nonspecific disorder in which the kidneys are damaged, causing them to leak...44 more...

MalaCards: Nephrotic Syndrome is related to steroid-resistant nephrotic syndrome and congenital nephrotic syndrome finnish type. An important gene associated with Nephrotic Syndrome is NPHS2 (nephrosis 2, idiopathic, steroid-resistant (podocin)), and among its related pathways are Tec Kinases Signaling and Statin Pathway, Pharmacodynamics. The drugs bumetanide and indapamide and the compounds cysteine and atp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and kidney, and related mouse phenotypes are mortality/aging and homeostasis/metabolism.

Aliases & Descriptions for Nephrotic Syndrome

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6Disease Ontology, 7diseasecard, 8DISEASES, 32Novoseek , 43UMLS, 19ICD9CM, 40SNOMED-CT, 24MeSH, 27NCIt
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Aliases & Descriptions:

nephrotic syndrome 6 7 8 32 43

External Ids:

ICD9CM19 581

Related Diseases for Nephrotic Syndrome

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13GeneCards, 14GeneDecks
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Disease types for nephrotic syndrome family:

nephrotic syndrome type 3 nephrotic syndrome, type 4
nephrotic syndrome, type 2

Diseases related to nephrotic syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1036)
idRelated DiseaseScoreTop Affiliating Genes
1steroid-resistant nephrotic syndrome39.7RELA, KIRREL, NAGLU, LMX1B, MYO1E, B2M
2congenital nephrotic syndrome finnish type36.6VTN, VEGFA, KDR, TTR, TF, NPHS1
3lipoid nephrosis35.6SERPINB7, NAGLU, CD79A, CD2AP, ITGB1, FCER2
4focal segmental glomerulosclerosis34.3VTN, RBP4, NAGLU, PAX2, CD79A, CD2AP
5proteinuria32.8PIK3C2A, LRP2, REN, KIRREL2, KIRREL, VWF
6familial nephrotic syndrome32.6KIRREL2, KIRREL, LAMB2, MAGI2, PLCE1, NPHS1
7hepatitis32.3RBP4, SELP, SERPINA1, GUSB, GSR, IL2RB
8nephrosis31.7SERPINC1, SERPINF2, LPL, LAMB2, B2M, IL10
9membranous glomerulonephritis31.5LRP2, VTN, SERPINB7, CLU, CD79A, CD2AP
10glomerulopathy30.9LRP2, REN, VWF, SELE, SELP, NAGLU
11antithrombin iii deficiency30.5SERPINC1, FGA, APOH, F5, F2, PLG
12hepatitis b30.2IL10, IL12B, IL17A, IL18, IL2RA, GPT
13acute poststreptococcal glomerulonephritis29.9SERPINF2, CFP, CD79A, CCL2, ALB, HP
14venous thrombosis29.8VWF, SELP, SERPINC1, SERPINF2, SERPINE1, CETP
15retinol binding protein29.5RETN, RBP4, VIM, NAGLU, LPA, LIPC
16thromboembolism29.5VWF, SELP, SERPINC1, SERPINF2, SERPINE1, FGA
17liver cirrhosis29.5REN, RETN, VTN, RBP4, SERPINC1, SERPINA7
18castleman's disease29.3VEGFA, B2M, IL10, IL6, IL7, CCL4
19amyloidosis29.2VWF, VTN, RBP4, SERPINC1, SERPINF2, LPA
20anuria29.1REN, ALB, HSD11B2, NR3C2, ACE, AGT
21renovascular hypertension29.0REN, ACE, AGTR1, NPPA, ADM
22hodgkin's lymphoma28.8SELP, CHRDL1, CD247, IL13, IL1RN, IL2
23thrombophilia28.6VWF, SELE, SELP, SERPINC1, SERPINF2, SERPINE1
24chronic kidney failure28.6REN, LPL, LEP, B2M, CD79A, INS
25hemophilia b28.5VWF, F9, F8, F3, F2, PF4
26short stature28.4REN, BRAF, LMX1B, LEP, CFI, INS
27lipid metabolism disorder28.4LPL, INS, APOA1, APOB, HLA-G
28renal cell carcinoma28.4RELA, PCNA, SELP, VIM, BRAF, VEGFA
29autoimmune hepatitis28.3CD14, CD40LG, GSTT1, GPT, F2, HSPG2
30endocarditis28.0PIK3C2A, VWF, GC, SELE, SERPINC1, SERPINA1
31t-cell leukemia27.8RELA, JUN, FOXP3, FCER2, IL2, IL2RA
32hyperlipidemia27.6PIK3C2A, RETN, VWF, RBP4, SELP, SERPINC1
33nephritis27.3LRP2, REN, VWF, VTN, PCNA, RBP4
34epidermolysis bullosa27.3VIM, LAMB3, JUN, CD79A, IL2RA, IL2RB
35thrombosis27.1PIK3C2A, REN, RETN, VWF, VTN, PCNA
36mycosis fungoides27.1PCNA, SELE, SELP, CLU, S100A8, CD40LG
37familial mediterranean fever27.0SELP, SERPINC1, SERPINE1, VEGFA, LMX1B, LEP
38pulmonary embolism26.9PIK3C2A, SERPINC1, SERPINF2, SERPINE1, VIM, MPO
39deep vein thrombosis26.8VWF, SELP, SERPINC1, SERPINE1, FGA, APOH
40tuberculosis26.7IL10, IL12B, IL1B, IL1RN, IL4, CCL2
41atopy26.7RELA, KITLG, SELP, VEGFA, KDR, CFI
42diabetic ketoacidosis26.6PIK3C2A, VWF, INS, IL10, IL18, IL6
43leukemia/lymphoma26.6KITLG, VEGFA, LEP, B2M, MPO, CD79A
44systemic lupus erythematosus26.5LRP2, VWF, VTN, RBP4, SELE, CLU
45type 2 diabetes mellitus26.4RETN, VWF, GC, RBP4, SELE, SELP
46wilms tumor26.4REN, VWF, PCNA, VIM, VEGFA, BMP6
47glomerulonephritis26.3LRP2, REN, KITLG, VWF, VTN, PCNA
48hepatitis c26.2SERPINA1, LIPC, LDLR, JUN, CD40LG, GSR
49lupus nephritis26.2VWF, VTN, PCNA, RBP4, SELE, SERPINE1
50nephropathy26.0LRP2, RELA, REN, RETN, KITLG, KIRREL

Graphical network of the top 20 diseases related to nephrotic syndrome:



Graphical network of diseases related to nephrotic syndrome

Clinical Features for Nephrotic Syndrome

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Drugs & Therapeutics for Nephrotic Syndrome

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for nephrotic syndrome

Drug clinical trials:

Search ClinicalTrials for nephrotic syndrome

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Search CenterWatch for nephrotic syndrome

Inferred drug relations via UMLS/NDF-RT:

43 28 bendroflumethiazide, benzthiazide, bumetanide, chlorothiazide, chlorothiazide sodium, chlorthalidone, cyclophosphamide, cyclothiazide, ethacrynate sodium, ethacrynic acid, furosemide, hydrochlorothiazide, hydroflumethiazide, indapamide, methyclothiazide, metolazone, polythiazide, quinethazone, torsemide, trichlormethiazide

Genetic Tests for Nephrotic Syndrome

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Anatomical Context for Nephrotic Syndrome

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22MalaCards
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MalaCards organs/tissues related to nephrotic syndrome:

22
Bone marrow, Heart, Kidney, Liver, Lung, Thyroid, Prostate, Testis, Monocytes, T cells, B cells, Endothelial

Phenotypes for genes affiliated with Nephrotic Syndrome

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25MGI
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MGI Mouse Phenotypes related to nephrotic syndrome:

25 (show all 26)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1mortality/agingMP:0010768INFPIK3C2A, RELA, REN, KITLG, KIRREL, KIF27
2homeostasis/metabolism phenotypeMP:0005376INFPIK3C2A, LRP2, RELA, REN, RETN, KITLG
3skeleton phenotypeMP:0005390INFLRP2, RELA, KITLG, GC, NAGLU, BRAF
4behavior/neurological phenotypeMP:0005386INFLRP2, REN, SELE, SELP, VIM, NAGLU
5nervous system phenotypeMP:0003631INFRELA, REN, KITLG, KIF27, VWF, SELP
6endocrine/exocrine gland phenotypeMP:0005379INFLRP2, PAX2, LDLR, CD40LG, CDKN1C, GUSB
7growth/size phenotypeMP:0005378INFPIK3C2A, LRP2, RELA, REN, KITLG, KIRREL
8cardiovascular system phenotypeMP:0005385INFRELA, REN, KITLG, KIF27, VWF, RBP4
9reproductive system phenotypeMP:0005389INFREN, RBP4, VEGFA, LIPC, PAX2, LEP
10no phenotypic analysisMP:000301210.4LRP2, PCNA, VEGFA, LMX1B, MYO1E, LEPR
11embryogenesis phenotypeMP:000538010.3SERPINC1, VIM, BRAF, ATF1, CD247, FCER1G
12craniofacial phenotypeMP:000538210.1LRP2, KITLG, KIF27, NAGLU, LMX1B, LAMB3
13liver/biliary system phenotypeMP:00053709.3RETN, SERPINC1, VEGFA, LPL, LCAT, MPV17
14adipose tissue phenotypeMP:00053758.1PIK3C2A, RETN, SERPINE1, BRAF, LPL, LEP
15renal/urinary system phenotypeMP:0005367INFLRP2, REN, KIRREL, SELP, NAGLU, BRAF
16digestive/alimentary phenotypeMP:0005381INFLRP2, KITLG, VWF, BRAF, VEGFA, LEP
17respiratory system phenotypeMP:0005388INFLRP2, KIF27, SELP, LPL, LEPR, CD14
18tumorigenesisMP:0002006INFKITLG, SERPINE1, BRAF, LEP, LEPR, B2M
19muscle phenotypeMP:0005369INFRELA, REN, RBP4, VIM, BRAF, VEGFA
20cellular phenotypeMP:0005384INFLRP2, RELA, KITLG, KIF27, VWF, PCNA
21vision/eye phenotypeMP:0005391INFLRP2, RELA, KITLG, RBP4, SELE, SELP
22normal phenotypeMP:0002873INFRELA, REN, VTN, RBP4, SELE, BRAF
23hematopoietic system phenotypeMP:0005397INFPCNA, BRAF, MYO1E, MPV17, FTH1, CD2AP
24other phenotypeMP:0005395INFCLU, KDR, LEPR, LDLR, CD40LG,
25immune system phenotypeMP:0005387INFREN, KIF27, VWF, SELP, VIM, NAGLU
26integument phenotypeMP:0010771INFRELA, KITLG, SELP, BRAF, LMX1B, LEPR

Publications for genes affiliated with Nephrotic Syndrome

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35PubMed
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Articles related to nephrotic syndrome:

(show top 50)    (show all 580)
idTitleAuthorsYearAffiliating Genes
1Glucocorticoid receptor auto-upregulation and its rel ation with glucocorticoid sensitivity in idiopathic nephrotic syndrome. (20419394)Chen P.... Cui Y.2011NR3C1
2Combined cyclosporine and prednisolone therapy in adu lt patients with the first relapse of minimal-change nephrotic syndrome. (19740915)Eguchi A.... Nitta K.2010ALB
3No regression of renal amyloid mass despite remission of nephrotic syndrome in a patient with TRAPS following etanercept therapy. (20091495)Simsek I.... Dinc A.2010TNF
4Nephrotic syndrome in diabetic kidney disease: an eva luation and update of the definition. (19556043)Stoycheff N.... Levey A.S.2009ALB
5Experience with tacrolimus in children with steroid-r esistant nephrotic syndrome. (19499248)Butani L.... Ramsamooj R.2009BMP6
6Potential donor-recipient MYH9 genotype interactions in posttransplant nephrotic syndrome after pediatric kidney transplantation. (19764949)Freedman B.I.... Reeves-Daniel A.M.2009MYH9
7Nucleotide variations in the NPHS2 gene in Greek children with steroid-resistant nephrotic syndrome. (19371226)Megremis S.... Traeger-Synodinos J.2009NPHS2
8Nail-patella syndrome, infantile nephrotic syndrome: complete remission with antiproteinuric treatment. (19147669)Proesmans W.... Devriendt K.2009LMX1B
9Specific podocin mutations determine age of onset of nephrotic syndrome all the way into adult life. (19282856)Hildebrandt F.... Heeringa S.F.2009NPHS2
10Urinary cytokines and steroid responsiveness in idiopathic nephrotic syndrome of childhood. (17914249)Woroniecki R.P.... Kaskel F.J.2008TGFB1
11Molecular pathology of nephrotic syndrome in childhood: a contemporary approach to diagnosis. (18462046)Liapis H.2008WT1, NPHS1, NPHS2
12HLA class I typing in Egyptian childhood minimal change nephrotic syndrome. (18949728)Donia A.F.... Moustafa F.e.l.-.H.2008HLA-A, HLA-B, HLA-S
13NPHS2 (podicin) mutations in Turkish children with idiopathic nephrotic syndrome. (17899208)Berdeli A.... Cakar N.2007NPHS2
14Ascites is the primary cause of cancer antigen-125 (CA-125) elevation in systemic lupus erythematosus (SLE) patients with nephrotic syndrome. (16979301)Basaran A.... Zafer Tuncer S.2007MUC16
15Anasarca improved by extracorporeal ultrafiltration through an internal shunt in a case of severe haemophilia B with inhibitor and steroid-resistant nephrotic syndrome. (16409185)Satomura A.... Mugishima H.2006F9
16Transient insulin-dependent diabetes mellitus in chil dren with steroid-dependent idiopathic nephrotic syndrome during tacrolimus tre atment. (16773407)Dittrich K.... DAPtsch J.2006INS
17Interleukin-17 concentration in serum and urine of children with idiopathic nephrotic syndrome (16898529)KiliA9-PstrusiA8ska K.... Kordecki H.2006IL17A
18Genetic basis of nephrotic syndrome--review. (16752799)Obeidova H.... Tesar V.2006WT1, ACTN4, TRPC6
19Genetic testing comes of age: WT1 mutations in steroid-resistant nephrotic syndrome: commentary on the article by Mucha et al. on page 325. (16439572)Benzing T.2006WT1
20T-cell transcriptome analysis points up a thymic disorder in idiopathic nephrotic syndrome. (15882260)Mansour H.... Deschenes G.2005MAL
21Polymorphism of the interleukin-4, interleukin-13, and signal transducer and activator of transcription 6 genes in Indonesian children with minimal change nephrotic syndrome. (15687724)Acharya B.... Gotoh A.2005STAT6, IL4, IL13
22Expression of nephrin in acquired forms of nephrotic syndrome in childhood. (14747939)Hingorani S.R.... Eddy A.A.2004NPHS1
23NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence. (15253708)Weber S.... Antignac C.2004NPHS1, NPHS2
24Transforming growth factor-beta1 in nephrotic syndrome treated with cyclosporine and ACE inhibitors. (15490252)Wasilewska A.M.... Zoch-Zwierz W.M.2004TGFB1, ACE
25Glucocorticoid receptors, in vitro steroid sensitivit y, and cytokine secretion in idiopathic nephrotic syndrome. (14717910)Carlotti A.P.... de Castro M.2004NR3C1, IL10
26Analysis on association of glucocorticoid receptor gene polymorphism with steroid-resistance in idiopathic nephrotic syndrome of children (14733805)Ye J.W.... Meng Q.2003NR3C1
27Polymorphisms of interleukin-4--related genes in Japanese children with minimal change nephrotic syndrome. (12900808)Kobayashi Y.... Morikawa A.2003STAT6, IL4, IL4R
28Predictors of peritonitis in children with nephrotic syndrome. (12185481)Hingorani S.R.... Watkins S.L.2002ALB
29The effects of gemfibrozil on hyperlipidemia in children with persistent nephrotic syndrome. (11858378)BA1yA1kAselik M.... Dikmen N.2002PIK3C2A, SLC17A5
30Recurrence of nephrotic syndrome in kidney grafts of patients with congenital nephrotic syndrome of the Finnish type: role of nephrin. (11884936)Patrakka J.... Jalanko H.2002NPHS1
31Serum glomerular permeability activity in patients with podocin mutations (NPHS2) and steroid-resistant nephrotic syndrome. (12089392)Carraro M.... Ghiggeri G.M.2002NPHS2
32Abnormal DNA-binding of transcription factors in minimal change nephrotic syndrome. (11605784)Cao C.... Zhao R.2001JUN, NR3C1
33A case of hepatitis B virus carrier complicated with nephrotic syndrome (10998920)Nakaji M.... Goto T.2000ALB
34Treatment of the nephrotic syndrome with etanercept in patients with the tumor necrosis factor receptor-associated periodic syndrome. (11023397)Drewe E.... Powell R.J.2000TNF
35Prothrombotic factors in nephrotic syndrome. (11218679)Saxena R.... Singh N.D.2000SERPINC1
36Tissue factor and inhibitor of the blood coagulation pathway in nephrotic syndrome (10740407)MaA8yszko J.S.... MyA9liwiec M.1999THBD, VTN
37Glomerular expression of nephrin is decreased in acquired human nephrotic syndrome. (10344367)Furness P.N.... Pringle J.H.1999NPHS1
38Circulating interleukin 2 receptor (IL2R) in nephrotic syndrome. (9067952)Hulton S.A.... Barratt T.M.1997IL2RA
39Plasma levels and urinary excretion of fibrinolytic and protease inhibitory proteins in nephrotic syndrome. (7518491)Vaziri N.D.... Barton C.H.1994SERPINF2
40Nephrotic syndrome associated with subacute bacterial endocarditis (SBE): a case report. (7570680)Yamauchi F.... Koide S.1994CFP
41T-cell subsets, interleukin-2 receptor expression and production of interleukin-2 in minimal change nephrotic syndrome. (7696095)Topaloglu R.... Kansu E.1994IL2RA
42Impact of tuberculosis in children with idiopathic nephrotic syndrome. (8398648)Kala U.... Thomson P.D.1993ALB
43Iso-oncotic volume expansion in the nephrotic syndrome. (8334809)Rabelink T.J.... Koomans H.A.1993ALB
44Plasma concentration and urinary excretion of erythropoietin in adult nephrotic syndrome. (1731507)Vaziri N.D.... Gonzales E.1992EPO
45Increased concentration of plasma cholesteryl ester transfer protein in nephrotic syndrome: role in dyslipidemia. (1479291)Moulin P.... Tall A.R.1992APOB, CETP
46Effect of frusemide on atrial natriuretic peptide, guanosine cyclic monophosphate, angiotensin II, aldosterone, vasopressin, prostaglandin E2 and blood volume in the nephrotic syndrome. (1652115)Jespersen B.... Pedersen E.B.1991NPPA
47Minimal change nephrotic syndrome with predominant m esangial IgA deposits: clinicopathological study (2051642)Soma J.... Yoshinaga K.1991CD79A
48A case of progressive systemic sclerosis with SjAPgren's syndrome complicated by nephrotic syndrome caused by bucillamine (2084858)Ogawa N.... Hishida A.1990HSPG2
49Antiproteinuric effect of captopril in a patient with lupus nephritis and intractable nephrotic syndrome. (2241292)Shapira Y.... Weinberger A.1990ALB
50Serum apolipoproteins A and B, lecithin: cholesterol acyl transferase activities and urinary cholesterol levels in nephrotic syndrome patients before and during steroid treatment. (2314540)Nayak S.S.... Aroor A.R.1990LCAT, APOB

Expression for genes affiliated with Nephrotic Syndrome

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Nephrotic Syndrome

Pathways for genes affiliated with Nephrotic Syndrome

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36QIAGEN, 34PharmGKB, 20KEGG, 37R&D Systems, 10EMD Millipore, 41Thomson Reuters
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Pathways related to nephrotic syndrome according to GeneDecks:

(show top 50)    (show all 90)
idPathwayScoreTop Affiliating Genes
1Tec Kinases Signaling36INFUTS2, BMP6, KITLG, STAT6, STAT3, TGFB1
2Statin Pathway, Pharmacodynamics3410.9APOE, ABCB1, HMGCR, APOC3, APOA1, LPL
3RAR-Gamma-RXR-Alpha Degradation3610.7CCL5, CCL13, CCL4, MAPK14, IL7, IL2
4Complement and coagulation cascades2010.6A2M, SERPINF2, SERPINC1, VWF, SERPINA1, SERPINE1
5Blood Coagulation Signaling Pathways3710.3THBD, PLG, PLAT, F2, F3, F5
6IL-6 Pathway3610.0STAT3, PF4, BRAF, BMP6, IL10, IL12B
7THC Differentiation Pathway3610.0IL12B, IL18, IL2, IL2RA, IL4, TNF
8Allograft rejection209.6TNF, HLA-DRB1, HLA-DQB1, HLA-B, IFNG, HLA-A
9Hematopoietic cell lineage209.5IL6, TFRC, EPO, KITLG, IL1R1, TNF
10PEDF Induced Signaling369.5CCL13, CCL2, CCL4, IL8, IL7, IL6
11MIF Mediated Glucocorticoid Regulation369.5CD14, MIF, IL10, IL12B, IL13, IL18
12all-trans-Retinoic Acid Signaling in Brain369.3BMP6, IL10, IL12B, IL13, IL18, IL1B
13Endothelin-1 Signaling Pathway369.3BRAF, BMP6, IL10, IL12B, IL13, IL18
14PAK Pathway369.2GH1, IGF1, CCL5, CCL13, CCL2, CCL4
15Renin-Angiotensin Pathway369.1IL6, IL2RA, IL2, JUN, KDR, UTS2
16Cytokine Network369.0TNF, IL10, IL12B, IFNG, IFNA2, IL8
17MIF Regulation of Innate Immune Cells369.0TNFSF10, NFKBIA, PF4, LTA, JUN, CD14
18Type I diabetes mellitus208.8HLA-DQB1, HLA-A, HLA-DRB1, LTA, HLA-G, TNF
19Malaria208.7SELE, TGFB1, TNF, IL8, IFNG, CCL2
20Amoebiasis208.7LAMB2, IL12B, TGFB1, NOS2, IL8, IL6
21SOCS Pathway368.6IL7, IL8, CCL4, CCL2, CCL13, CCL5
22Immune response MIF-mediated glucocorticoid regulation108.5NOS2, NR3C1, TNF, IFNG, IL8, IL6
23Immune response_MIF-mediated glucocorticoid regulation418.5JUN, RELA, NOS2, NR3C1, TNF, IFNG
24Rheumatoid arthritis208.2TGFB1, IFNG, CCL5, CCL2, IL8, IL6
25Influenza A208.2HLA-DQB1, HLA-DRB1, IL8, RELA, JUN, IL12B
26Immune response MIF in innate immunity response107.9NFKBIA, IL6, RELA, NOS2, IL1B, JUN
27Immune response_MIF in innate immunity response417.8NFKBIA, IL1B, NOS2, TNF, IFNG, MAPK14
28Immune response IL-1 signaling pathway107.8IL6, RELA, CP, EDN1, NFKBIA, NOS2
29Immune response_IL-1 signaling pathway417.8TNF, NOS2, IL1B, EDN1, CP, F3
30Chagas disease (American trypanosomiasis)207.6IL12B, IL10, CD247, JUN, SERPINE1, RELA
31TGF-Beta Pathway36INFIL4R, KDR, UTS2, BMP6, KITLG, JUN
32PGC1Alpha Pathway36INFTNFSF10, CCL5, CCL13, CCL4, MAPK14, IL8
33Toxoplasmosis20INFMAPK14, RELA, HLA-DQB1, HLA-DRB1, IFNG, NOS2
34Cytokine-cytokine receptor interaction20INFEPO, TGFB1, LTA, PF4, PPBP, TNFSF10
35Rho Family GTPases36INFPF4, PPBP, SPP1, TNFSF10, GH1, HSPG2
36MAPK Signaling36INFSTAT3, TGFB1, LTA, PPBP, SPP1, TNF
37Regulation of eIF4 and p70S6K36INFCCL4, MAPK14, CCL13, , IL12B, IL13
38NFAT Signaling and Lymphocyte Interactions36INF, IL2, IL13, IL12B, FCER2, FCER1G
39Antioxidant Action of Vitamin-C36INFTNFSF10, NFKBIA, PF4, LTA, TGFB1, MYH9
40ERK Signaling36INF, IL10, IL12B, IL13, IL18, IL1B
41Leishmaniasis20INFNFKBIA, IL10, IL12B, IL1B, IL4, C3
42JAK-STAT Pathway36INFTNFSF10, IL6, IL4R, IL4, , IL2RA
43MAPK Family Pathway36INFCCL5, CCL13, CCL2, CCL4, MAPK14, IL8
44p38 Signaling36INFKITLG, BMP6, UTS2, KDR, IL10, IL12B
45Glucocorticoid Receptor Signaling36INFCCL13, CCL2, CCL4, MAPK14, IL8, IL7
46Molecular Mechanisms of Cancer36INFCCL13, CCL5, GH1, TNFSF10, SPP1, PPBP
47STAT3 Pathway36INFCCL13, CCL2, CCL4, MAPK14, IL8, IL7
48Akt Signaling36INFIL6, LTA, PF4, TNF, CCL5, IL4R
49Pertussis20INFC3, RELA, JUN, CD14, NOS2, IL1B
50Jak-STAT signaling pathway20INFSTAT6, LEPR, IL10, IL12B, IL13RA1, IL2

Compounds for genes affiliated with Nephrotic Syndrome

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32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
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Compounds related to nephrotic syndrome according to GeneDecks:

(show top 50)    (show all 520)
idCompoundScoreTop Affiliating Genes
1cysteine32 INFVTN, PCNA, RBP4, SELP, SERPINA1, NAGLU
2atp32 INFPIK3C2A, VTN, GCA, VIM, BRAF, LIPC
3heparin32 9 18 9 INFPIK3C2A, LRP2, KITLG, VWF, VTN, SERPINF2
4cyclosporin a32 42 INFPIK3C2A, KITLG, VWF, SELP, NAGLU, LPL
5fibrinogen32 INFPIK3C2A, RETN, VTN, GC, SELE, SELP
612-o-tetradecanoylphorbol 13-acetate32 INFBRAF, BMP6, ATF1, , FCER2, IL1R1
7dexamethasone32 42 34 9 9 INFREN, RETN, KITLG, VWF, VTN, PCNA
8oxygen32 18 INFPIK3C2A, KITLG, RBP4, SERPINF2, SERPINA1, NAGLU
9lysine32 11.4RELA, SERPINF2, SERPINA1, LDLR, LCAT, FTH1
10ptca32 11.0PIK3C2A, SELP, SERPINF2, FGA, APOH, CCL5
11potassium32 9 18 9 13.9PIK3C2A, REN, KITLG, VTN, NAGLU, BRAF
12vitamin b1232 10.6LRP2, VWF, PCNA, LPA, B2M, MPO
13carbohydrates32 10.6SELE, SELP, LDLR, CFI, CETP, CD14
14txb232 10.5REN, VWF, SELP, SERPINF2, NAGLU, LPA
15alpha tocopherol32 10.5RBP4, LPL, LEP, LDLR, LCAT, CETP
16pge232 10.5REN, VTN, SELE, LDLR, ATF1, CD14
17dermatan sulfate32 10.4VWF, VTN, SELP, SERPINC1, BMP6, GUSB
18theophylline32 9 18 9 13.3SELP, LPL, B2M, CD79A, CD40LG, IL10
19zidovudine32 9 9 12.1KITLG, LPL, B2M, GUSB, IL10, IL2
20ascorbic acid32 18 10.9PCNA, RBP4, LDLR, LCAT, CFP, FTH1
21acetaminophen32 34 9 18 9 13.8PCNA, GC, B2M, GPT, GPX3, IGHE
22bezafibrate32 9 9 11.7PIK3C2A, SERPINE1, LPA, LPL, LIPC, LDLR
23gnrh32 9.7KITLG, SERPINE1, VIM, LEP, LEPR, MKI67
24chloramphenicol32 9 9 11.7GC, SELE, SERPINC1, SERPINA7, SERPINE1, VIM
25quinapril32 9 9 11.6REN, VWF, SELE, SELP, SERPINE1, CRP
26lycopene32 18 10.5PCNA, LPL, LDLR, CETP, GSR, GSTP1
27metformin32 34 9 9 11.8RETN, VWF, SERPINE1, LPL, LEP, INS
28fenofibrate32 9 9 10.7PIK3C2A, RETN, SELE, SELP, SERPINE1, VIM
29acetylcholine32 9 18 9 11.5PIK3C2A, VWF, VIM, LPL, BMP6, UTS2
30polymyxin b32 8.1SELE, SERPINE1, LDLR, CD14, IL10, IL1B
31curcumin32 7.8VTN, VEGFA, LDLR, JUN, MIF, GSTP1
32s-nitroso-n-acetylpenicillamine32 7.7IL1B, IL8, MAPK14, IFNG, CAT, NOS1
3315-deoxy-delta-12,14-prostaglandin j232 7.0SERPINE1, VEGFA, BMP6, JUN, IL10, IL1B
34retinoid32 INFRBP4, VIM, BMP6, S100A8, JUN, CD14
35sodium dodecylsulfate32 INFVWF, VTN, SERPINA7, SERPINF2, SERPINE1, LPA
36glutamate32 INFVTN, PCNA, GC, VIM, BRAF, BMP6
37verapamil32 34 9 18 9 INFREN, NAGLU, UTS2, LDLR, GSTP1, IL2RA
38matrigel32 INFVWF, VTN, SELE, SERPINE1, VIM, BRAF
39paclitaxel32 34 9 9 INFKITLG, PCNA, VIM, BRAF, VEGFA, BMP6
40vitamin d32 INFLRP2, GC, SERPINE1, VIM, NAGLU, LPL
41endotoxin32 INFRETN, GC, SERPINF2, LEPR, S100A8, CD14
42prednisolone32 9 9 INFPIK3C2A, KITLG, VWF, BMP6, MUC16, MPO
43cholesterol32 9 18 9 INFPIK3C2A, LRP2, REN, RETN, KITLG, VWF
44arginine32 INFPIK3C2A, REN, VWF, VTN, SERPINC1, SERPINA7
45norepinephrine32 9 18 9 INFPIK3C2A, REN, RETN, KITLG, VWF, SELE
46neopterin32 INFNAGLU, B2M, CD79A, CD14, CD40LG, FCER2
47leucine32 INFRBP4, SERPINA7, VIM, NAGLU, LPA, SCARB2
48okt332 INFSELE, BMP6, CD79A, CD40LG, FCER2, IL10
49latex32 INFKITLG, VWF, VTN, RBP4, NAGLU, FTH1
50il 1032 INFBMP6, IL10, IL12B, IL13, IL18, IL1B

GO Terms for genes affiliated with Nephrotic Syndrome

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12Gene Ontology
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Cellular components related to nephrotic syndrome according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:009897INFFCER2, IL13, IL17A, , IL4, MCAM
2extracellular regionGO:005576INFHSPG2, PLAT, PLG, PF4, KLK3, A2M
3extracellular spaceGO:005615INFIL1RN, CCL4, CCL2, CCL13, CCL5, GPC5
4plasma membraneGO:005886INFKIRREL3, KDR, LEPR, LDLR, MUC16, LCP1
5platelet alpha granule lumenGO:03109310.5F5, ALB, HRG, PPBP, PLG, PF4
6high-density lipoprotein particleGO:03436410.3PON1, APOH, APOE, APOA1, CETP, LCAT
7lysosomal lumenGO:04320210.1NEU1, DCN, CUBN, HPSE, HSPG2, GPC5
8slit diaphragmGO:03605710.1NPHS2, NPHS1, TRPC6, MAGI2, IQGAP1, KIRREL2
9extracellular matrixGO:0310129.9F3, HSPG2, PLAT, DCN, SOD1, SLPI
10cytoplasmGO:005737INFPLCE1, NOS1, NOS2, NOS3, RP1, NFKBIA

Biological processes related to nephrotic syndrome according to GeneDecks:

(show all 44)
idNameGO IDScoreTop Affiliating Genes
1lipoprotein metabolic processGO:04215711.1CUBN, HSPG2, ALB, APOE, APOC3, APOB
2cholesterol metabolic processGO:00820311.0APOC3, APOE, CAT, CYP11A1, CUBN, STAR
3reverse cholesterol transportGO:04369111.0APOE, APOC3, APOA1, CETP, LCAT, CLU
4female pregnancyGO:00756510.8THBD, TGFB1, STS, NPPA, ADM, HSD11B2
5lipid metabolic processGO:00662910.8APOB, APOC3, APOE, ALB, HSPG2, CUBN
6low-density lipoprotein particle remodelingGO:03437410.8AGTR1, AGT, PLA2G7, APOB, MPO, CETP
7response to insulin stimulusGO:03286810.7GAL, ADM, NPPA, NR3C1, HSD11B2, CCL5
8high-density lipoprotein particle remodelingGO:03437510.6APOE, APOC3, APOA1, CETP, LCAT, LIPC
9platelet degranulationGO:00257610.6SOD1, TF, TGFB1, ACTN4, A2M, PF4
10cell adhesionGO:00715510.6CCL4, CCL2, F8, AMBP, F5, SPP1
11negative regulation of fibrinolysisGO:05191810.6CPB2, THBD, PLG, HRG, F2, APOH
12positive regulation of B cell proliferationGO:03089010.5ADA, PTPRC, IL7, IL4, IL2, IL13
13fibrinolysisGO:04273010.5CPB2, PLG, PLAT, HRG, F2, SERPINE1
14cellular response to tumor necrosis factorGO:07135610.4GATA3, EDN1, CYP11A1, CCL5, CCL2, APOB
15negative regulation of blood coagulationGO:03019510.3THBD, EDN1, APOH, APOE, SERPINE1, VTN
16response to lipopolysaccharideGO:03249610.2LTA, EDN1, THBD, DCN, ADM, EPO
17regulation of blood pressureGO:00821710.1NPPC, NPPA, SOD1, ACE, NOS3, CALCA
18positive regulation of cellular protein metabolic processGO:03227010.0ADIPOQ, TGFB1, AGTR1, AGT, NFKBIA, INS
19immune responseGO:00695510.0HLA-B, HLA-A, IGHE, CCL13, CCL4, HLA-DQB1
20positive regulation of angiogenesisGO:0457669.9ADM, C3, NOS3, F3, CCL5, ANXA3
21positive regulation of vasodilationGO:0459099.9ADM, NPPC, NOS3, NOS1, CALCA, INS
22lipopolysaccharide-mediated signaling pathwayGO:0316639.9TGFB1, NFKBIA, NOS3, TNF, CCL5, CCL2
23platelet activationGO:0301689.9SOD1, TF, TGFB1, ACTN4, A2M, PF4
24positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.8AGT, GH1, CAT, F2, IGF1, CCL5
25negative regulation of apoptotic processGO:0430669.8IL1RN, IL4, IL6, IL7, ALB, CAT
26cell surface receptor signaling pathwayGO:0071669.8IFNA2, IFNG, F2, PTPRC, EDN1, CCL2
27small molecule metabolic processGO:0442819.8CUBN, CYP11A1, HMGCR, HPSE, CAT, HSPG2
28response to hyperoxiaGO:0550939.6NOS3, CAT, ALOX5, IL18, SERPINE1, EPO
29cell-cell signalingGO:0072679.5CCL13, CCL5, IFNA2, CALCA, TNFSF10, LTA
30response to glucocorticoid stimulusGO:0513849.5IGFBP2, HSD11B2, TNF, PLAT, ADM, ADIPOQ
31anti-apoptosisGO:0069169.5F3, GLO1, TPT1, TNF, NR3C1, NOS3
32positive regulation of smooth muscle cell proliferationGO:0486619.3EDN1, TNF, IGF1, CCL5, IL6, IL13
33cellular response to lipopolysaccharideGO:0712229.1LTC4S, NOS2, CYP11A1, IFNG, CCL2, IL8
34acute-phase responseGO:0069538.8STAT3, CRP, F2, F8, IL6, IL1RN
35response to hypoxiaGO:0016668.2LTA, UTS2, VEGFA, SERPINA1, LEP, IL18
36agingGO:007568INFEPO, CCL2, IL1B, , JUN, SERPINA7
37leukocyte cell-cell adhesionGO:007159INFPTPRC, CALCA, EZR, CCL5, , CD40LG
38inflammatory responseGO:006954INFGAL, C3, , TGFB1, LTA4H, CRP
39cytokine-mediated signaling pathwayGO:019221INFHLA-A, HLA-B, HLA-DQB1, HLA-DRB1, HLA-G, PF4
40blood coagulationGO:007596INFTGFB1, THBD, ACTN4, A2M, PF4, NOS3
41positive regulation of peptidyl-tyrosine phosphorylationGO:050731INFADIPOQ, AGT, GH1, IGF1, IL6, INS
42response to ethanolGO:045471INFSTAT3, SOD1, NPPC, ADIPOQ, GATA3, NOS3
43negative regulation of cell proliferationGO:008285INFTNF, PLG, NOS3, WT1, AGT, TGFB1
44response to drugGO:042493INFIL10, , JUN, B2M, UTS2, LPL

Molecular functions related to nephrotic syndrome according to GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:005515INFHRG, RP1, NFKBIA, RHO, WT1, LTC4S
2heparin bindingGO:00820110.8APOE, APOH, CCL2, CCL5, HRG, PTPRC
3eukaryotic cell surface bindingGO:04349910.3ADIPOQ, TGFB1, APOH, FGA, SERPINF2, SELP
4hormone activityGO:0051799.7TTR, NPPA, NPPC, ADM, ADIPOQ, EPO
5receptor bindingGO:0051029.1HLA-B, HLA-G, TNFSF10, NOS2, LTA, NPPA
6growth factor activityGO:0080839.0IL7, IGF1, F2, GH1, PPBP, AGT
7cytokine activityGO:0051258.6IL12B, IL13, IL17A, IL18, IL1B, IL2
8protein homodimerization activityGO:0428038.6NOS2, CRP, NR3C1, CUBN, PTPRO, HLA-G
9protein heterodimerization activityGO:046982INFAPOB, APOE, MAF, NR3C1, PDSS2, LTC4S
10protease bindingGO:002020INFTNF, F3, IL1R1, INS, , SERPINE1

Sources for Nephrotic Syndrome

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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