MCID: NPH012
MIFTS: 67

Nephrotic Syndrome malady

Genetic diseases, Nephrological diseases, Rare diseases, Immune diseases categories
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Summaries for Nephrotic Syndrome

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Wikipedia:65 Nephrotic syndrome is a nonspecific kidney disorder characterised by a number of signs of disease:... more...

MalaCards based summary: Nephrotic Syndrome is related to diffuse mesangial sclerosis and denys-drash syndrome. An important gene associated with Nephrotic Syndrome is NPHS2 (nephrosis 2, idiopathic, steroid-resistant (podocin)), and among its related pathways are Selected targets of C EBPalpha and Nephrin/Neph1 signaling in the kidney podocyte. The drugs bendroflumethiazide and bumetanide and the compounds kp-1019 and iopentol have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and endothelial, and related mouse phenotypes are nervous system and endocrine/exocrine gland.

Aliases & Classifications for Nephrotic Syndrome

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 27ICD9CM, 57SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
See all sources

Nephrotic Syndrome, Aliases & Descriptions:

Name: Nephrotic Syndrome 8 10 44 62


Classifications:



External Ids:

Disease Ontology8 DOID:1184
ICD9CM27 581
MeSH34 D009404
NCIt39 C34845
ICD1025 N04, N04.9

Related Diseases for Nephrotic Syndrome

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Diseases in the Nephrotic Syndrome Type 3 family:

Familial Nephrotic Syndrome nephrotic syndrome
Hereditary Nephrotic Syndromes Nephrotic Syndrome, Type 2
Nephrotic Syndrome, Type 4 Nephrotic Syndrome, Type 6
Nephrotic Syndrome, Type 10 Nephrotic Syndrome, Type 7
Nephrotic Syndrome, Type 8 Nephrotic Syndrome, Type 9
Nephrotic Syndrome, Type 1

Diseases related to Nephrotic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 454)
idRelated DiseaseScoreTop Affiliating Genes
1diffuse mesangial sclerosis31.2WT1, NPHS2, NPHS1
2denys-drash syndrome31.2WT1
3frasier syndrome31.1WT1
4chronic pyelonephritis31.1NAGLU
5nail-patella syndrome30.9NPHS2, CD2AP
6nephrosis30.9LAMB2, ACTN4, NPHS1, NPHS2
7membranoproliferative glomerulonephritis30.9NPHS1, CD79A
8hypertension30.8MPV17, ALB, CD79A
9congenital nephrotic syndrome finnish type30.7ACTN4, NPHS1, NPHS2, CD2AP, WT1
10nephritis30.7MPV17, ALB, NPHS1, NPHS2, CD79A
11pyelonephritis30.7NAGLU, CD79A
12membranous glomerulonephritis30.6ALB, NPHS1, NPHS2, CD2AP, CD79A
13nephroblastoma30.5WT1, NPHS1
14conjunctivitis30.3CD79A
15acute poststreptococcal glomerulonephritis30.3CD79A
16lupus nephritis30.3NAGLU, ALB, CD79A
17glomerulonephritis30.3PTPRO, NAGLU, ACTN4, ALB, NPHS1, NPHS2
18diabetes mellitus30.2TF, NAGLU, ALB, NPHS1, CD79A
19glomerulosclerosis30.1PTPRO, MPV17, ACTN4, ALB, NPHS1, NPHS2
20diabetic nephropathy30.1NPHS2, NPHS1, ALB, NAGLU, TF
21pneumonia30.1CD79A, IL13, NAGLU
22wilms tumor30.0PTPRO, ACTN4, NPHS1, NPHS2, CD2AP, WT1
23focal segmental glomerulosclerosis30.0WT1, CD79A, CD2AP, NPHS2, PTPRO, NAGLU
24tetanus29.9CD79A, ALB, IL13
25lipoid nephrosis29.8TF, NAGLU, IL13, ALB, NPHS1, NPHS2
26proteinuria29.4WT1, CD79A, TF, PTPRO, MPV17, CD2AP
27chronic kidney failure29.0TF, NAGLU, ACTN4, ALB, NPHS1, NPHS2
28steroid-resistant nephrotic syndrome11.1
29amyloidosis10.7
30familial nephrotic syndrome10.6
31hepatitis10.6
32syphilis10.5
33pierson syndrome10.5
34proliferative glomerulonephritis10.5
35thromboembolism10.5
36hyperthyroxinemia10.5ALB
37cerebritis10.5
38hepatorenal syndrome10.5ALB
39microcephaly, hiatal hernia and nephrotic syndrome10.4
40nephrotic syndrome, type 110.4
41endotheliitis10.4
42secondary syphilis10.4
43peritonitis10.4
44nephrotic syndrome type 310.4
45hepatitis b10.4
46nephrotic syndrome, type 5, with or without ocular abnormalities10.4
47strongyloidiasis10.4
48hypothyroidism10.4
49interstitial nephritis10.4
50thyroiditis10.4

Graphical network of the top 20 diseases related to Nephrotic Syndrome:



Diseases related to nephrotic syndrome

Symptoms for Nephrotic Syndrome

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Drugs & Therapeutics for Nephrotic Syndrome

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Genetic Tests for Nephrotic Syndrome

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Anatomical Context for Nephrotic Syndrome

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MalaCards organs/tissues related to Nephrotic Syndrome:

32
Kidney, T cells, Endothelial, Testes, Bone, Thyroid, Liver, Lung, B cells, Heart, Monocytes, Prostate, Neutrophil, Eye, Whole blood, Brain, Spinal cord, Pancreas, Breast, Skin, Testis, Cervix, Appendix, Bone marrow

Animal Models for Nephrotic Syndrome or affiliated genes

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Publications for Nephrotic Syndrome

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Articles related to Nephrotic Syndrome:

(show top 50)    (show all 1669)
idTitleAuthorsYear
1
Change of Chylous Ascites During Low-Density Lipoprotein Apheresis in a Patient With Idiopathic Nephrotic Syndrome. (25256915)
2014
2
Is Two Month Initial Prednisolone Treatment for Nephrotic Syndrome Inferior to Longer Duration Therapy?: Pediatric Nephrologist's Viewpoint. (25362014)
2014
3
PD42 - Is rituximab a trigger for persistent hypogammaglobulinemia in idiopathic nephrotic syndrome? (25045499)
2014
4
Immunosuppressive treatment for idiopathic membranous nephropathy in adults with nephrotic syndrome. (25318831)
2014
5
Close association between proteinuria and regulatory T cells in patients with idiopathic nephrotic syndrome. (23263711)
2013
6
Letter to the editor regarding 'Youssef et al.'s multi-drug resistance-1 gene polymorphisms in nephrotic syndrome: Impact on susceptibility and response to steroids' (24374471)
2013
7
Familial steroid-sensitive idiopathic nephrotic syndrome: seven cases from three families in China. (23778422)
2013
8
Role of PCSK9 and IDOL in the pathogenesis of acquired LDL receptor deficiency and hypercholesterolemia in nephrotic syndrome. (24166456)
2013
9
Patterns of childhood nephrotic syndrome in Aljouf region, Saudi Arabia. (24029283)
2013
10
Profound nephrotic syndrome in a patient with ovarian teratoma. (23816730)
2013
11
Association of the ACE-II genotype with the risk of nephrotic syndrome in Pakistani children. (22033511)
2012
12
Long-term outcome of the difficult nephrotic syndrome in children. (22982908)
2012
13
Intra- and postoperative adverse events in children with nephrotic syndrome requiring surgery under general anesthesia. (22142331)
2012
14
NPHS2 mutations in Indian children with sporadic early steroid resistant nephrotic syndrome. (22080622)
2012
15
Acute inferior myocardial infarction with nephrotic syndrome. (21159478)
2012
16
Nephrotic syndrome occurring during tiopronin treatment for cystinuria. (20924604)
2011
17
Successful treatment of steroid-resistant nephrotic syndrome associated with WT1 mutations. (20191369)
2010
18
Clinical features of the nephrotic syndrome associated with ichthyosis vulgaris and analysis of related gene mutation]. (20441703)
2010
19
Successful use of single-dose rituximab for the maintenance of remission in a patient with steroid-resistant nephrotic syndrome. (19881243)
2009
20
Randomized cross-over trial comparing albumin and frusemide infusions in nephrotic syndrome. (19142668)
2009
21
Interleukin-18 expression in peripheral blood mononuclear cells in children with steroid-resistant nephrotic syndrome]. (19470251)
2009
22
Clinical features and long-term outcome of nephrotic syndrome associated with heterozygous NPHS1 and NPHS2 mutations. (19406966)
2009
23
Nephrotic syndrome in diabetic kidney disease: an evaluation and update of the definition. (19556043)
2009
24
Congenital nephrotic syndrome. (17968594)
2009
25
Low prevalence of NPHS2 mutations in African American children with steroid-resistant nephrotic syndrome. (18543005)
2008
26
Fetuin A in children with nephrotic syndrome]. (18924506)
2008
27
Podocyte proteoglycan synthesis is involved in the development of nephrotic syndrome. (16622173)
2006
28
Angiotensin-converting enzyme gene polymorphism in children with idiopathic nephrotic syndrome. (16645262)
2006
29
Glucocorticoid receptor and vascular endothelial growth factor in nephrotic syndrome. (16825140)
2006
30
Genetic variations of the NR3C1 gene in children with sporadic nephrotic syndrome. (16890204)
2006
31
Relationship of serum interleukin-7 concentration and the coagulation state in children with nephrotic syndrome. (16091081)
2005
32
Varicella-induced remission of steroid-resistant nephrotic syndrome in a child. (17642785)
2004
33
Apolipoprotein E in idiopathic nephrotic syndrome and focal segmental glomerulosclerosis. (12631135)
2003
34
Insulin resistance, dyslipidaemia, inflammation and endothelial function in nephrotic syndrome. (12454236)
2002
35
Congenital nephrotic syndrome. (11261689)
2001
36
Pregnancy outcome in nephrotic syndrome with mixed connective tissue disease. (11598404)
2001
37
Mutation spectrum in the nephrin gene (NPHS1) in congenital nephrotic syndrome. (11317351)
2001
38
The role of lung scintigraphy in the diagnosis of nephrotic syndrome with pulmonary embolism. (10698409)
2000
39
Recombinant human erythropoietin for anaemia in nephrotic syndrome with thalassemia. (9128797)
1997
40
Nephrotic syndrome and concurrent infectious mononucleosis. (9090679)
1997
41
A prospective clinical trial comparing the treatment of idiopathic membranous nephropathy and nephrotic syndrome with simvastatin and diet, versus diet alone. (8905205)
1996
42
Role of renal insufficiency in altered erythropoietin metabolism in the nephrotic syndrome. (1524095)
1992
43
Lovastatin in the treatment of hypercholesterolemia in nephrotic syndrome due to diabetic nephropathy stage IV-V. (1638777)
1992
44
rT3 metabolism in patients with nephrotic syndrome and normal GFR compared with normal subjects. (2018127)
1991
45
Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome. (1696177)
1990
46
Nephrotic syndrome in two members of a family with mercury poisoning. (2136288)
1990
47
Neonatal cytomegalovirus infection with pancreatic cystadenoma and nephrotic syndrome. (3035523)
1986
48
Renal amyloidosis with nephrotic syndrome in a child suspected of having idiopathic pulmonary hemosiderosis. (617983)
1977
49
Nephrotic syndrome and secondary syphilis. (1175490)
1975
50
Nephrotic syndrome: a complication of secondary syphilis. (5124440)
1971

Variations for Nephrotic Syndrome

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Expression for genes affiliated with Nephrotic Syndrome

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Expression patterns in normal tissues for genes affiliated with Nephrotic Syndrome

Search GEO for disease gene expression data for Nephrotic Syndrome.

Pathways for genes affiliated with Nephrotic Syndrome

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Pathways related to Nephrotic Syndrome according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ALB, TF
29.6CD2AP, NPHS2, NPHS1
39.4PLCE1, ARHGDIA
49.3CD2AP, NPHS1, ACTN4
5
Show member pathways
9.3CD2AP, NPHS1, ACTN4
6
Show member pathways
9.3TF, ACTN4, ALB
7
Show member pathways
8.9PLCE1, IL13, ACTN4, PTPRO
8
Show member pathways
8.9CD79A, PLCE1, ITGA3, LAMB2
9
Show member pathways
8.8TF, ACTN4, ITGA3, ALB
10
Show member pathways
Cytoskeleton remodeling Fibronectin binding integrins in cell motility60
Cytoskeleton remodeling Integrin outside in signaling60
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases60
Cell adhesion Tight junctions60
Development MAG dependent inhibition of neurite outgrowth60
8.7ACTN4, ITGA3, ARHGDIA
11
Show member pathways
7.7LAMB2, ACTN4, ITGA3, IL13, PLCE1, ARHGDIA

Compounds for genes affiliated with Nephrotic Syndrome

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Compounds related to Nephrotic Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1kp-10194410.2TF, ALB
2iopentol4410.2ALB, NAGLU
3bismuth44 2411.2ALB, TF
4p-aminohippuric acid4410.2ALB, NAGLU
5gelfoam4410.2ALB, TF
6aluminium44 1111.1NAGLU, TF
7suprofen44 1111.1TF, ALB
8inulin4410.1NAGLU, ALB
9iohexol4410.1NAGLU, ALB
10puromycin aminonucleoside4410.0CD2AP, NPHS2, NPHS1
11fructosamine44 2411.0ALB, NAGLU
12ovomucoid449.9IL13, TF
13tetracycline44 1110.9TF, ALB, WT1
14gamma globulin449.8ALB, CD79A
15perindopril44 50 1111.8ALB, NAGLU
16diclofenac44 28 50 1112.7NAGLU, IL13, ALB
17ramipril44 1110.6CD79A, ALB
18glutaraldehyde449.6TF, ALB, CD79A
19vitamin b12449.6TF, ALB, CD79A
20alpha tocopherol449.6ALB, IL13, TF
21polyethylene glycol449.5TF, ALB, CD79A
22piroxicam44 1110.5CD79A, ALB
23praziquantel44 1110.5CD79A, IL13
24cyclophosphamide44 50 1111.4NPHS2, IL13, NAGLU, TF
25penicillin449.4TF, IL13, CD79A
26sialic acid449.4CD79A, NAGLU, TF
27vitamin a44 24 1111.3TF, NAGLU, IL13, ALB
28vitamin d449.3NAGLU, ALB, CD79A, WT1
29citrate449.2TF, NAGLU, ALB, CD79A
30methotrexate50 44 1111.2CD79A, ALB, NAGLU, TF
31carbachol44 28 1111.2TF, IL13, CD79A
32indomethacin44 28 61 1112.1CD79A, NPHS1, ALB, IL13
33inositol449.1TF, IL13, CD79A
34prednisolone44 28 1111.1CD79A, ALB, IL13, TF
35thyroxine44 2410.1CD79A, ALB, IL13, TF
36histamine44 28 2411.0CD79A, ALB, IL13, TF
37hyaluronic acid44 249.8NAGLU, IL13, ALB, CD79A, WT1
38vegf448.8TF, IL13, NPHS1, CD79A, WT1
39heparin44 28 24 1111.8CD79A, ALB, IL13, NAGLU, LAMB2
40tacrolimus44 50 1110.7CD79A, ALB, IL13, NAGLU, TF
41lactate448.7TF, NAGLU, IL13, ALB, CD79A
42aspartate448.6ALB, IL13, NAGLU, TF
43cyclosporin a44 28 6110.6TF, NAGLU, IL13, NPHS2, CD79A, WT1
44alanine448.6TF, NAGLU, IL13, ALB, CD79A
45calcium44 50 24 1111.5LAMB2, NAGLU, ACTN4, PLCE1, ALB, NPHS1
46creatinine448.5TF, NAGLU, ALB, NPHS1, NPHS2, CD79A
47retinoic acid44 249.4ITGA3, IL13, NPHS1, CD79A, WT1
48tyrosine448.3PTPRO, ACTN4, ITGA3, IL13, NPHS1, NPHS2
49cysteine448.3NAGLU, IL13, ALB, CD79A, WT1
50steroid448.0WT1, PTPRO, NAGLU, IL13, NPHS1, NPHS2

GO Terms for genes affiliated with Nephrotic Syndrome

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Cellular components related to Nephrotic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:0360579.9NPHS2, NPHS1
2protein complexGO:0432349.2ACTN4, ALB, NPHS1, NPHS2
3membrane raftGO:0451219.1NPHS1, NPHS2, CD79A
4perinuclear region of cytoplasmGO:0484718.7ACTN4, ITGA3, CD2AP, TF
5extracellular vesicular exosomeGO:0700626.2TF, ARHGDIA, NPHS2, NPHS1, ALB, ITGA3

Biological processes related to Nephrotic Syndrome according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1metanephric glomerular visceral epithelial cell developmentGO:07224910.1NPHS2, LAMB2
2glomerular visceral epithelial cell differentiationGO:07211210.0WT1, PTPRO
3glomerular basement membrane developmentGO:0328369.9MPV17, NPHS1, WT1
4glomerulus developmentGO:0328359.9WT1, PTPRO, PLCE1
5retina homeostasisGO:0018959.8ALB, TF
6heart developmentGO:0075079.5WT1, PLCE1, ITGA3
7platelet degranulationGO:0025769.4TF, ACTN4, ALB
8platelet activationGO:0301689.0ALB, ACTN4, TF
9blood coagulationGO:0075968.7TF, ACTN4, ITGA3, ALB

Molecular functions related to Nephrotic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:0051789.2LAMB2, ACTN4, ITGA3
2protein bindingGO:0055155.5TF, PTPRO, ACTN4, ITGA3, IL13, PLCE1

Products for genes affiliated with Nephrotic Syndrome

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Sources for Nephrotic Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet