MCID: NPH012
MIFTS: 66

Nephrotic Syndrome malady

Nephrological diseases category

Summaries for Nephrotic Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Nephrotic syndrome is a nonspecific kidney disorder characterised by a number of signs of disease:... more...

MalaCards: Nephrotic Syndrome is related to glomerulonephritis and focal segmental glomerulosclerosis. An important gene associated with Nephrotic Syndrome is NPHS2 (nephrosis 2, idiopathic, steroid-resistant (podocin)), and among its related pathways are Rho Family GTPases and Nephrin interactions. The drugs cyclophosphamide and bendroflumethiazide and the compounds calcium and creatinine have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and endothelial, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Nephrotic Syndrome

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

nephrotic syndrome 8 10 44 60


External Ids:

Disease Ontology8 DOID:1184
MeSH34 D009404
ICD9CM27 581
NCIt39 C34845
ICD1025 N04, N04.9

Related Diseases for Nephrotic Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Nephrotic Syndrome, Type 1 family:

Familial Nephrotic Syndrome nephrotic syndrome
Nephrotic Syndrome Type 3 Nephrotic Syndrome, Type 2
Nephrotic Syndrome, Type 4 Nephrotic Syndrome, Type 6
Nephrotic Syndrome, Type 7 Nephrotic Syndrome, Type 8
Nephrotic Syndrome, Type 9

Diseases related to Nephrotic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 415)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.1ACTN4, NAGLU, CD2AP, CD79A, NPHS2, NPHS1
2focal segmental glomerulosclerosis31.1CD79A, NPHS2, NPHS1, WT1, CD2AP, NAGLU
3amyloidosis30.9F9, CD79A, ALB
4proteinuria30.8ALB, ACTN4, KIRREL, NAGLU, CD2AP, CD79A
5hepatitis30.8F9
6membranous glomerulonephritis30.7NPHS1, NPHS2, CD79A, CD2AP, ALB
7lipoid nephrosis30.6NAGLU, CD2AP, CD79A, TF, NPHS2, NPHS1
8hypertension30.6ALB, CD79A, MPV17, PPBP
9peritonitis30.5ALB
10hepatitis b30.5ALB, CD79A, F9
11hypothyroidism30.5F9
12thyroiditis30.4CD79A
13denys-drash syndrome30.4WT1
14membranoproliferative glomerulonephritis30.4CD79A, NPHS1
15arthritis30.4ALB, IL13
16nail-patella syndrome30.3NPHS2, CD2AP, LMX1B
17pyelonephritis30.3NAGLU, CD79A
18chronic pyelonephritis30.3NAGLU
19iga glomerulonephritis30.3NPHS1, NPHS2, CD79A, CD2AP, NAGLU, ALB
20frasier syndrome30.2WT1
21pancreatitis30.2ALB
22lupus erythematosus30.2CD79A
23myeloma30.2CD79A, NAGLU, IL4R, ALB
24myocardial infarction30.2F9, PPBP, NAGLU
25pneumonia30.2IL13, NAGLU, CD79A
26rheumatoid arthritis30.2PPBP, CD79A, NAGLU, IL13, IL4R
27liver cirrhosis30.2TF, ALB
28atherosclerosis30.1ALB, PPBP
29diabetic nephropathy30.0NPHS1, NPHS2, TF, NAGLU, ALB
30tuberculosis30.0CD79A, IL4R, ALB
31purpura30.0CD79A
32lung cancer30.0ALB
33chronic kidney failure29.8WT1, NPHS1, NPHS2, PPBP, TF, CD79A
34nephrosis29.8LAMB2, ACTN4, NPHS2, NPHS1
35meningitis29.8PPBP, CD79A, ALB
36schistosomiasis29.8IL13, CD79A, PPBP
37thrombocytopenia29.8ALB, CD79A, PPBP, F9
38type 2 diabetes mellitus29.8ALB, NAGLU, NPHS1, F9
39graves' disease29.8IL13, IL4R
40cystic fibrosis29.8F9, ALB
41eosinophilia29.8IL13, CD79A
42inflammatory bowel disease29.8CD79A
43bronchitis29.8CD79A
44sarcoidosis29.8IL13
45acquired immunodeficiency syndrome29.8ALB
46esophagitis29.8IL13
47diabetic retinopathy29.8NAGLU, ALB
48crohn's disease29.8ALB
49disseminated intravascular coagulation29.8F9, PPBP
50leishmaniasis29.8IL13

Graphical network of the top 20 diseases related to Nephrotic Syndrome:



Diseases related to nephrotic syndrome

Clinical Features for Nephrotic Syndrome

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Drugs & Therapeutics for Nephrotic Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Nephrotic Syndrome

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Anatomical Context for Nephrotic Syndrome

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32MalaCards
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MalaCards organs/tissues related to Nephrotic Syndrome:

32
Kidney, T cells, Endothelial, Testes, Thyroid, Bone, Liver, Lung, Heart, B cells, Monocytes, Prostate, Cervix, Eye, Spinal cord, Testis, Skin, Breast, Whole blood, Pancreas, Brain, Bone marrow

Animal Models for Nephrotic Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nephrotic Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.1CD79A, MPV17, TF, NPHS2, NPHS1, WT1
2MP:001076812.0CD2AP, MPV17, TF, NPHS2, NPHS1, WT1
3MP:000536711.8ALB, WT1, NPHS1, NPHS2, MPV17, CD79A
4MP:000537811.6WT1, NPHS2, TF, MPV17, CD2AP, NAGLU
5MP:000538411.4CD2AP, CD79A, MPV17, WT1, NAGLU, IL13
6MP:000539711.4F9, WT1, TF, MPV17, CD79A, CD2AP
7MP:000538711.2CD2AP, CD79A, WT1, F9, NAGLU, IL13
8MP:000537011.0WT1, MPV17, NAGLU, IL4R, ALB, F9
9MP:000538510.9F9, WT1, NPHS2, MPV17, CD2AP, NAGLU

Publications for Nephrotic Syndrome

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50PubMed
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Articles related to Nephrotic Syndrome:

(show top 50)    (show all 1618)
idTitleAuthorsYear
1
Steroids combined with levothyroxine to treat children with idiopathic nephrotic syndrome: a retrospective single-center study. (24389651)
2014
2
Profound nephrotic syndrome in a patient with ovarian teratoma. (23816730)
2013
3
Prophylaxis of thromboembolic events in patients with nephrotic syndrome. (23613095)
2013
4
Relapse of minimal change nephrotic syndrome after intravitreal bevacizumab. (23782377)
2013
5
Outcome of severe steroid-dependent nephrotic syndrome treated with mycophenolate mofetil. (22890513)
2013
6
Subclinical non-autoimmune hypothyroidism in children with steroid resistant nephrotic syndrome. (23584882)
2013
7
Treatment outcome of late steroid-resistant nephrotic syndrome: a study by the Midwest Pediatric Nephrology Consortium. (23633037)
2013
8
B lymphocyte cytokine profile in a monozygotic twin pair discordant for nephrotic syndrome. (23397174)
2013
9
Digital pathology evaluation in the multicenter Nephrotic Syndrome Study Network (NEPTUNE). (23393107)
2013
10
A molecular genetic analysis of childhood nephrotic syndrome in a cohort of Saudi Arabian families. (23595123)
2013
11
Intra- and postoperative adverse events in children with nephrotic syndrome requiring surgery under general anesthesia. (22142331)
2012
12
Necrotizing fasciitis caused by Serratia marcescens: a fatal complication of nephrotic syndrome. (22401347)
2012
13
Co-administration of albumin and furosemide in patients with the nephrotic syndrome. (22382243)
2012
14
Significance of electron dense deposits in patients with minimal change nephrotic syndrome. (23109993)
2012
15
A rare cause of childhood-onset nephrotic syndrome: lipoprotein glomerulopathy. (22874113)
2012
16
Urinary exosomal WT1 in childhood nephrotic syndrome. (22076591)
2012
17
Glomerular density-associated changes in clinicopathological features of minimal change nephrotic syndrome in adults. (22123493)
2011
18
Protein-protein interaction heterogeneity of plasma apolipoprotein A1 in nephrotic syndrome. (21416664)
2011
19
CD2AP mutations are associated with sporadic nephrotic syndrome and focal segmental glomerulosclerosis (FSGS). (19131354)
2009
20
Immunosuppressive treatment of idiopathic membranous glomerulonephritis with nephrotic syndrome]. (20088170)
2009
21
Is dyslipidemia sustained during remission of nephrotic syndrome genetically determined? Evaluation of genetic polymorphisms of proteins involved in lipoprotein metabolism in children and adolescents with nephrotic syndrome. (19341173)
2009
22
Mesothelioma of the testis and nephrotic syndrome: a case report. (19830148)
2009
23
alpha1-antitrypsin (A1AT) deficiency presenting with IgA nephropathy and nephrotic syndrome: is renal involvement caused by A1AT deposition? (18793532)
2008
24
Oxidative modification of low-density lipoprotein in relation to dyslipidemia and oxidant status in children with steroid sensitive nephrotic syndrome. (18356747)
2008
25
Nephrotic syndrome due to primary systemic AL amyloidosis, successfully treated with VAD (vincristine, doxorubicin and dexamethasone) alone. (18344643)
2008
26
Patients with mutations in NPHS2 (podocin) do not respond to standard steroid treatment of nephrotic syndrome. (14978175)
2004
27
Association of IL-1beta, IL-1ra, and TNF-alpha gene polymorphisms in childhood nephrotic syndrome. (14758530)
2004
28
Genetic forms of nephrotic syndrome. (15503167)
2004
29
Implications of serum TNF-beta and IL-13 in the treatment response of childhood nephrotic syndrome. (12697154)
2003
30
Leptin in patients wit nephrotic syndrome]. (15224534)
2003
31
Left atrial thrombus without mitral valve disease in a patient with nephrotic syndrome: report of a case. (12444438)
2002
32
Predictors of peritonitis in children with nephrotic syndrome. (12185481)
2002
33
Pathogenesis of edema formation in the nephrotic syndrome. (11322379)
2001
34
Significantly rapid relief from steroid-resistant nephrotic syndrome by LDL apheresis compared with steroid monotherapy. (11721158)
2001
35
Immunohistochemical analysis of renin activity in chronic cyclosporine nephropathy in childhood nephrotic syndrome. (11095649)
2000
36
46,XY gonadal dysgenesis associated with congenital nephrotic syndrome and sepsis. (10603151)
1999
37
Rapid normalization of interleukin-8 production after low-density lipoprotein apheresis in steroid-resistant nephrotic syndrome. (10412778)
1999
38
Strongyloidiasis associated with nephrotic syndrome. (9711888)
1998
39
The full induction of human apoprotein A-I gene expression by the experimental nephrotic syndrome in transgenic mice depends on cis-acting elements in the proximal 256 base-pair promoter region and the trans-acting factor early growth response factor 1. (9541501)
1998
40
Cerebral venous thrombosis in nephrotic syndrome. (9403217)
1997
41
Coagulopathy of childhood nephrotic syndrome--a reappraisal of the role of natural anticoagulants and fibrinolysis. (8979144)
1996
42
Diuretic effect of frusemide in patients with nephrotic syndrome: is it potentiated by intravenous albumin? (7833755)
1995
43
Inefficacy and toxicity of pefloxacin in focal and segmental glomerulosclerosis with steroid-resistant nephrotic syndrome. (8099164)
1993
44
The role of cow's milk protein intolerance in steroid-resistant nephrotic syndrome. (1290843)
1992
45
Membranous glomerulonephritis and the nephrotic syndrome in a patient with Landry-Guillain-BarrAc-Strohl syndrome. (2728436)
1989
46
Neonatal cytomegalovirus infection with pancreatic cystadenoma and nephrotic syndrome. (3035523)
1986
47
Clinical features and glomerular immunofluorescence of renal biopsies from children with nephrotic syndrome due to minimal change disease and two variants of mesangial proliferative glomerulonephritis. (6370883)
1984
48
Membranous glomerulonephropathy and nephrotic syndrome associated with iatrogenic metallic mercury poisoning in a cat. (7257162)
1981
49
Familial nephrotic syndrome and focal segmental glomerulosclerosis. (7193718)
1981
50
Nephrotic syndrome and acute hepatitis in secondary syphilis. (4981755)
1969

Genetic Variations for Nephrotic Syndrome

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Expression for genes affiliated with Nephrotic Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephrotic Syndrome

Search GEO for disease gene expression data for Nephrotic Syndrome.

Pathways for genes affiliated with Nephrotic Syndrome

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51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems
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Compounds for genes affiliated with Nephrotic Syndrome

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Nephrotic Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.7ACTN4, LAMB2, ALB, NPHS2, PLCE1, IL4R
2creatinine4411.7F9, TF, PPBP, NPHS2, NPHS1, WT1
3steroid4411.7WT1, LMX1B, NAGLU, CD2AP, NPHS1, IL13
4tyrosine4411.6IL13, PPBP, NPHS2, NPHS1, F9, LMX1B
5cyclosporin a44 28 5913.6TF, F9, WT1, IL4R, IL13, NAGLU
6alanine4411.5F9, ALB, PPBP, TF, CD79A, IL13
7cysteine4411.4CD79A, NAGLU, ALB, PPBP, WT1, IL13
8citrate4411.4ALB, F9, PPBP, TF, CD79A, NAGLU
9hyaluronic acid44 2412.4WT1, PPBP, CD79A, IL13, ALB, NAGLU
10heparin44 28 11 2414.4CD79A, LAMB2, IL13, F9, NAGLU, PPBP
11histamine44 28 2413.4TF, ALB, PPBP, CD79A, IL13, IL4R
12lactate4411.4TF, CD79A, NAGLU, IL13, PPBP, ALB
13thymidine44 2412.4NAGLU, IL13, IL4R, WT1, PPBP, F9
14prednisolone44 28 1113.3TF, CD79A, IL13, F9, ALB
15lipid4411.3NPHS2, NPHS1, F9, PPBP, CD2AP, NAGLU
16tacrolimus44 49 1113.3ALB, TF, IL13, NAGLU, CD79A
17dexamethasone44 49 28 1114.3F9, NPHS1, CD79A, IL13, PPBP, IL4R
18vegf4411.3NPHS1, WT1, CD79A, IL13, TF, PPBP
19fibrinogen4411.3PPBP, TF, CD79A, ALB, F9
20penicillin4411.2CD79A, TF, PPBP, IL13
21glutamine4411.2TF, WT1, F9, IL4R, IL13
22sialic acid4411.2CD79A, TF, NAGLU, F9
23puromycin aminonucleoside4411.2CD2AP, NPHS2, NPHS1
24thyroxine44 2412.2TF, IL13, CD79A, ALB
25cyclophosphamide44 49 1113.2NAGLU, TF, NPHS2
26iohexol4411.1ALB, PPBP, NAGLU
27warfarin44 49 11 2414.1F9, PPBP, CD79A
28silicone4411.1PPBP, F9, CD79A
29glutaraldehyde4411.1TF, CD79A, ALB
30methotrexate44 49 1113.1ALB, NAGLU, CD79A, TF
31desmopressin44 59 28 1114.1NAGLU, PPBP, F9
32kp-10194411.0ALB, TF
33diclofenac44 28 49 1114.0ALB, IL13, NAGLU
34iodixanol4411.0NAGLU, PPBP
35Bismuth Subsalicylate1111.0ALB, TF
36ivig4411.0ALB, F9, CD79A
37iopentol4411.0ALB, NAGLU
38p-aminohippuric acid4411.0ALB, NAGLU
39vitamin b124410.9TF, CD79A, ALB
40aluminium44 1111.9TF, NAGLU
41aspartate4410.9ALB, NAGLU
42vitamin a44 11 2412.9NAGLU
43rituximab44 49 1112.8CD79A, F9, IL13
44tween 804410.8F9, ALB
45bismuth44 2411.8ALB, TF
46allergens4410.8CD79A, IL4R, IL13
47suprofen44 1111.6TF, ALB
48ovomucoid4410.6TF
49gelfoam4410.5ALB, TF
50indomethacin44 59 28 1113.5ALB, IL13, CD79A, NPHS1

GO Terms for genes affiliated with Nephrotic Syndrome

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16Gene Ontology
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Cellular components related to Nephrotic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:03605710.6NPHS2, NPHS1
2platelet alpha granule lumenGO:03109310.4ALB, ACTN4, PPBP

Biological processes related to Nephrotic Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:00257611.0ALB, ACTN4, TF, PPBP
2glomerular basement membrane developmentGO:03283610.9MPV17, NPHS1, WT1
3platelet activationGO:03016810.8PPBP, TF, ACTN4, ALB
4excretionGO:00758810.8KIRREL, NPHS2, NPHS1
5blood coagulationGO:00759610.8F9, PPBP, TF, ACTN4, ALB
6metanephric glomerular visceral epithelial cell developmentGO:07224910.8NPHS2, LAMB2
7positive regulation of macrophage activationGO:04303210.6IL4R, IL13
8glomerulus developmentGO:03283510.3PLCE1, WT1

Products for genes affiliated with Nephrotic Syndrome

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Sources for Nephrotic Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet