MCID: NPH012
MIFTS: 60

Nephrotic Syndrome

Categories: Nephrological diseases, Genetic diseases, Rare diseases, Blood diseases, Immune diseases

Aliases & Classifications for Nephrotic Syndrome

MalaCards integrated aliases for Nephrotic Syndrome:

Name: Nephrotic Syndrome 12 72 36 28 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 51 41 14 69
Finnish Congenital Nephrotic Syndrome 69
Finnish Congenital Nephrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1184
ICD10 32 N04 N04.9
ICD9CM 34 581
MeSH 41 D009404
NCIt 46 C34845
KEGG 36 H01657

Summaries for Nephrotic Syndrome

MalaCards based summary : Nephrotic Syndrome, also known as finnish congenital nephrotic syndrome, is related to sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis and familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation, and has symptoms including edema An important gene associated with Nephrotic Syndrome is NPHS2 (NPHS2, Podocin), and among its related pathways/superpathways are Interferon gamma signaling and Hexose transport. The drugs Methylprednisolone and Mycophenolate mofetil have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and bone, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Nephrotic syndrome is a collection of symptoms due to kidney damage. This includes protein in the urine,... more...

Related Diseases for Nephrotic Syndrome

Diseases in the Nephrotic Syndrome family:

Nephrotic Syndrome, Type 1 Nephrotic Syndrome, Type 4
Nephrotic Syndrome, Type 2 Nephrotic Syndrome, Type 3
Nephrotic Syndrome, Type 6 Nephrotic Syndrome, Type 7
Nephrotic Syndrome, Type 8 Nephrotic Syndrome, Type 9
Nephrotic Syndrome, Type 10 Nephrotic Syndrome, Type 11
Nephrotic Syndrome, Type 12 Nephrotic Syndrome, Type 13
Nephrotic Syndrome 14 Nephrotic Syndrome 15
Nephrotic Syndrome 16 Familial Nephrotic Syndrome

Diseases related to Nephrotic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 533)
# Related Disease Score Top Affiliating Genes
1 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis 33.6 PLCE1 WT1
2 familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 33.4 NPHS1 PTPRO
3 pierson syndrome 33.4 LAMB2 NPHS2
4 familial idiopathic steroid-resistant nephrotic syndrome with minimal changes 33.2 EMP2 NPHS1 NPHS2 PTPRO
5 sporadic idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis 33.1 CD2AP NPHS2
6 nephrotic syndrome, type 1 33.0 ACTN4 CD2AP NPHS1 NPHS2 WT1
7 lipoid nephrosis 32.9 ALB CD2AP NPHS1 NPHS2
8 familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis 32.7 ARHGDIA NPHS1 NUP93 PLCE1 PTPRO WT1
9 familial nephrotic syndrome 32.5 ACTN4 CD2AP ITGA3 NPHS1 NPHS2 PLCE1
10 galloway-mowat syndrome 32.5 ACTN4 LAMB2 NPHS1 NPHS2 NUP107
11 denys-drash syndrome 32.0 CD2AP NPHS1 NPHS2 WT1
12 membranous nephropathy 32.0 ALB CD2AP NPHS1 NPHS2
13 diffuse mesangial sclerosis 31.8 ARHGDIA LAMB2 NPHS1 NPHS2 PLCE1 WT1
14 hypoparathyroidism, sensorineural deafness, and renal disease 31.2 ACTN4 LAMB2 NPHS1 NPHS2
15 frasier syndrome 31.2 ACTN4 CD2AP NPHS1 NPHS2 PLCE1 WT1
16 focal segmental glomerulosclerosis 31.1 ACTN4 ALB CD2AP COQ6 LAMB2 NPHS1
17 focal segmental glomerulosclerosis 1 30.8 ACTN4 CD2AP COQ8B NPHS1 NPHS2 NUP107
18 glomerulonephritis 30.4 ALB NPHS1 NPHS2
19 crescentic glomerulonephritis 29.5 NPHS2 PTPRO WT1
20 chronic kidney failure 29.5 ALB B2M NPHS1 NPHS2
21 familial lcat deficiency 29.4 ALB APOA1
22 iga glomerulonephritis 29.2 ALB CD2AP NPHS1 NPHS2
23 kidney disease 28.6 ACTN4 ALB B2M CD2AP NPHS1 NPHS2
24 nephrotic syndrome, type 2 12.3
25 nephrotic syndrome, type 5, with or without ocular abnormalities 12.3
26 nephrotic syndrome, type 3 12.3
27 congenital nephrotic syndrome finnish type 12.3
28 nephrotic syndrome, type 7 12.2
29 nephrotic syndrome, type 6 12.2
30 nephrotic syndrome, type 4 12.2
31 interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital 12.2
32 nephrotic syndrome, type 9 12.2
33 nephrotic syndrome, type 11 12.2
34 nephrotic syndrome, type 12 12.2
35 nephrotic syndrome, type 8 12.1
36 nephrotic syndrome 15 12.1
37 nephrotic syndrome 14 12.1
38 nephrotic syndrome, type 10 12.1
39 nephrotic syndrome, type 13 12.1
40 nephrotic syndrome, idiopathic, steroid-resistant 12.0
41 idiopathic steroid-sensitive nephrotic syndrome with focal segmental hyalinosis 12.0
42 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 11.9
43 sporadic idiopathic steroid-resistant nephrotic syndrome with minimal changes 11.9
44 idiopathic steroid-sensitive nephrotic syndrome with minimal change 11.9
45 idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation 11.9
46 sporadic idiopathic steroid-resistant nephrotic syndrome with collapsing glomerulopathy 11.9
47 nephrotic syndrome ocular anomalies 11.8
48 leigh syndrome with nephrotic syndrome 11.8
49 coenzyme q10 deficiency, primary, 6 11.8
50 galloway-mowat syndrome 1 11.8

Graphical network of the top 20 diseases related to Nephrotic Syndrome:



Diseases related to Nephrotic Syndrome

Symptoms & Phenotypes for Nephrotic Syndrome

UMLS symptoms related to Nephrotic Syndrome:


edema

MGI Mouse Phenotypes related to Nephrotic Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.15 ACTN4 APOA1 ARHGDIA B2M CD2AP EMP2
2 homeostasis/metabolism MP:0005376 10.1 ITGA3 LAMB2 NPHS1 NPHS2 PLCE1 SGPL1
3 endocrine/exocrine gland MP:0005379 10.02 ACTN4 ALB APOA1 ARHGDIA B2M CD2AP
4 mortality/aging MP:0010768 9.93 B2M CD2AP COQ6 ITGA3 LAMB2 NPHS1
5 neoplasm MP:0002006 9.43 ACTN4 ALB B2M ITGA3 PLCE1 WT1
6 renal/urinary system MP:0005367 9.36 ARHGDIA CD2AP ITGA3 LAMB2 NPHS1 NPHS2

Drugs & Therapeutics for Nephrotic Syndrome

Drugs for Nephrotic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 187)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
2
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3 128794-94-5 5281078
3
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
4
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
5
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
6
rituximab Approved Phase 4,Phase 2,Phase 3 174722-31-7 10201696
7
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
8
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
9
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
10
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
11
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
12
Pravastatin Approved Phase 4,Phase 1 81093-37-0 54687
13
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
14
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 10883523 5280795 6221
15
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
16
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 11103-57-4 445354
17
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
18
Alfacalcidol Approved, Nutraceutical Phase 4 41294-56-8 5282181
19 Tocopherol Approved, Investigational, Nutraceutical Phase 4
20
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
21 Cyclosporins Phase 4,Phase 2
22 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
23 Methylprednisolone acetate Phase 4,Phase 3,Phase 2
24 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2
25 Prednisolone acetate Phase 4,Phase 3,Phase 2
26 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2
27 Prednisolone phosphate Phase 4,Phase 3,Phase 2
28 Vaccines Phase 4
29 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
30 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
31 glucocorticoids Phase 4,Phase 3,Phase 2
32 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
33 Hormones Phase 4,Phase 3,Phase 2,Phase 1
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
35 Antiemetics Phase 4,Phase 3,Phase 2
36 Autonomic Agents Phase 4,Phase 3,Phase 2
37 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
38 Neuroprotective Agents Phase 4,Phase 3
39 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
40 Protective Agents Phase 4,Phase 3
41 Antirheumatic Agents Phase 4,Phase 2,Phase 3
42 Calcineurin Inhibitors Phase 4,Phase 2,Phase 3
43 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
44 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2
45 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2
46 Anti-Infective Agents Phase 4,Phase 3,Phase 1,Phase 2
47 Antitubercular Agents Phase 4,Phase 3
48 Adrenocorticotropic Hormone Phase 4,Phase 3,Phase 2,Phase 1
49 beta-endorphin Phase 4,Phase 3,Phase 2,Phase 1
50 Immunoglobulin A Phase 4

Interventional clinical trials:

(show top 50) (show all 118)

# Name Status NCT ID Phase Drugs
1 Study of 7-valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome Unknown status NCT01346007 Phase 4
2 Low Dose Steroids in the Treatment of Nephrotic Syndrome Relapse Unknown status NCT02216747 Phase 4 prednisone 60 mg/meter square Body Surface Area;prednisone 45 mg;prednisone 30 mg
3 Long Term Tapering or Standard Steroids for Nephrotic Syndrome Unknown status NCT00308321 Phase 4 long term tapering of prednisolone;standard prednisolone treatment
4 Therapeutic Effect of Tacrolimus on Primary Nephrotic Syndrome in Children Completed NCT01162005 Phase 4 Tacrolimus
5 Mycophenolate Mofetil in Pediatric Steroid Dependent Nephrotic Syndrome Completed NCT01895894 Phase 4 Mycophenolate mofetil
6 Treatment of Resistant Nephrotic Syndrome With ACTH Gel (ACTHAR) Completed NCT01129284 Phase 4 ACTHAR gel
7 A Study to Evaluate the Effect of Tacrolimus and Corticosteroid Combination Therapy in Patients With Minimal Change Nephrotic Syndrome Completed NCT01763580 Phase 4 Tacrolimus;Prednisolone
8 Urinary Aquaporin 2 and Expression of the NPHS2 Gene in Adults Suffering From Nephrotic Syndrome Completed NCT00286910 Phase 4
9 Pharmacokinetics of Tacrolimus in Children Completed NCT03347357 Phase 4 Tacrolimus
10 Prospective Study Evaluating the Effect of Repository Corticotropin in the Treatment of Various Nephrotic Syndromes Completed NCT01021540 Phase 4 Repository corticotrophin
11 Role of Acetazolamide and Hydrochlorothiazide Followed by Furosemide in Treating Nephrotic Edema Completed NCT02427880 Phase 4 Acetazolamide and Hydrochlorothiazide Followed by Furosemide;Furosemide and Hydrochlorothiazide Followed by Furosemide
12 Acthar for Treatment of Proteinuria in Membranous Nephropathy Patients Completed NCT01386554 Phase 4 Repository Corticotropin Injection;Placebo
13 Adrenocorticotropic Hormone (ACTH) Treatment of Nephrotic Range Proteinuria in Diabetic Nephropathy (NRDN) Completed NCT01028287 Phase 4 ACTH;ACTH
14 Efficacy of Usual Vitamin D Supplementation and Its Impact on Children and Adolescents Calciuria. Completed NCT02238418 Phase 4 Cholecalciferol vial (100 000 UI)
15 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
16 Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Resistant Nephrotic Syndrome Recruiting NCT02382575 Phase 4 Rituximab;Tacrolimus
17 Myfortic® for Minimal Change Nephrotic Syndrome (MCNS): a Randomized Study Recruiting NCT01185197 Phase 4 Myfortic plus low-dose steroid;Prednisolone
18 Tacrolimus Versus Prednisolone for the Treatment of Minimal Change Disease Recruiting NCT00982072 Phase 4 tacrolimus;prednisolone
19 Tacrolimus Combined With Entecavir on HBV Associated Glomerulonephritis(HBV-GN) Recruiting NCT03062813 Phase 4 Tacrolimus &entecavir;placebo & entecavir
20 Mycophenolate Mofetil Plus Steroid in the Treatment Of Patients With Progressive Idiopathic Membranous Nephropathy Recruiting NCT03170323 Phase 4 Mycophenolate Mofetil;Cyclosporins
21 Mycophenolate Mofetil and Tacrolimus Versus Tacrolimus for the Treatment of Idiopathic Membranous Glomerulonephritis (IMG) Active, not recruiting NCT00843856 Phase 4 tacrolimus;tacrolimus and mycophenolate mofetil
22 Adjusted Steroids Therapy in Childerens With Idiopathic Nephrotic Syndrome Not yet recruiting NCT02649413 Phase 4 Prednisone
23 ACTHAR Gel for Drug REsistant Nephrotic Syndrome in Children Not yet recruiting NCT03408405 Phase 4 Acthar Gel 80 UNT/ML Injectable Solution
24 Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy Not yet recruiting NCT03210688 Phase 4 Prednisolone;Alfacalcidol
25 Anti-Oxidant Therapy In Chronic Renal Insufficiency (ATIC) Study Terminated NCT00384618 Phase 4 pravastatin;vitamin E
26 Rituximab Trial for Pediatric Nephrotic Syndrome Unknown status NCT01716442 Phase 2, Phase 3 Rituximab;Placebo
27 Efficacy of Rituximab For the Treatment of Calcineurin Inhibitors Dependent Nephrotic Syndrome During Childhood Completed NCT01268033 Phase 2, Phase 3 Rituximab;Placebo
28 Cyclophosphamide Versus Mycophenolate Mofetil for the Treatment of Steroid-dependent Nephrotic Syndrome in Children Completed NCT01092962 Phase 3 Cyclophosphamide;Mycophenolate mofetil
29 Efficacy of Pentoxifylline on Primary Nephrotic Syndrome Completed NCT00354731 Phase 3 pentoxifylline;Corticosteroid
30 Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Dependent Nephrotic Syndrome Completed NCT02438982 Phase 3 Tacrolimus;Rituximab
31 Evaluation of Low Dose Corticosteroids Efficiency, Associated With Myfortic ® in the Treatment of Nephrotic Syndrome Completed NCT01197040 Phase 3 Prednisone;acid mycophenolic (Myfortic)
32 The Efficacy and Tolerance of Tacrolimus Sustained-release Capsules on Refractory Nephrotic Syndrome (RNS) Completed NCT01309477 Phase 3 Tacrolimus Sustained-release Capsules (ADVAGRAF)
33 Tacrolimus Combined With Prednisone Treatment of Idiopathic Membranous Nephropathy and Nephrotic Syndrome Completed NCT00362531 Phase 2, Phase 3 tacrolimus combined with prednisone
34 Prospective, Multicenter Study of the Efficacy and Tolerance of Tacrolimus on Refractory Nephrotic Syndrome (RNS) Completed NCT00615667 Phase 3 tacrolimus (FK506)
35 Rituximab in Multirelapsing Minimal Change Disease (MCD) or Focal Segmental Glomerulosclerosis (FSGS) Completed NCT00981838 Phase 3 Rituximab
36 Steroid Treatment for Kidney Disease Completed NCT00065611 Phase 3 Oral dexamethasone
37 Rituximab in Membranous Nephropathy Completed NCT00425217 Phase 2, Phase 3 Rituximab
38 Study of the Safety and Efficacy of NC-503 in Secondary (AA) Amyloidosis Completed NCT00035334 Phase 2, Phase 3 NC-503 (Anti-amyloidotic (AA) Agent)
39 Therapeutic Effect of Tacrolimus in Combination With Low Dose Corticosteroid in Adult Patient With Minimal Change Nephritic Syndrome Completed NCT01084980 Phase 2, Phase 3 Tacrolimus
40 Adrenocorticotropic Hormone (ACTH) for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome Recruiting NCT02132195 Phase 3 ACTH
41 Prednisolone Trial in Children Younger Than 4 Years Recruiting NCT03141970 Phase 3 Prednisolone
42 Valproic Acid for Idiopathic Nephrotic Syndrome Recruiting NCT02896270 Phase 2, Phase 3 Valproic Acid
43 Rituximab Versus Steroids and Cyclophosphamide in the Treatment of Idiopathic Membranous Nephropathy Recruiting NCT03018535 Phase 3 Rituximab;Methylprednisolone;Cyclophosphamide
44 A Study to Evaluate the Efficacy and Safety of Mizoribine in the Treatment of Refractory Nephrotic Syndrome Active, not recruiting NCT02257697 Phase 3 Mizoribine (MZR);Cyclophosphamide (CTX)
45 Evaluate Rituximab Treatment for Idiopathic Membranous Nephropathy Active, not recruiting NCT01508468 Phase 3 symptomatic treatment (Converting Enzyme inhibitor, Angiotensin II, Anti-renin, Aldosterone antagonist diuretic, Beta blocker, Calcium inhibitor, statin);experimental (Non Immunosuppressive Symptomatic Treatment (NIST) and Rituximab)
46 Efficiency of Levamisole for Maintaining Remission After the First Flare of Steroid Sensitive Nephrotic Syndrome in Children Not yet recruiting NCT02818738 Phase 3 Levamisole Hydrochloride
47 Efficacy of Rituximab in Comparison to Continued Corticosteroid Treatment in Idiopathic Nephrotic Syndrome Not yet recruiting NCT03298698 Phase 3 Rituximab;Prednisone
48 Randomized Trial Comparing Rituximab Against Mycophenolate Mofetil in Children Wtih Refractory Nephrotic Syndrome Terminated NCT02390362 Phase 3 Rituximab;MMF
49 IL-2 for Multi Drug Resistant Nephrotic Syndrome Completed NCT02455908 Phase 1, Phase 2 Proleukin®
50 Drug Therapy in Lupus Nephropathy Completed NCT00001212 Phase 2 prednisone;cyclophosphamide;cyclosporin A

Search NIH Clinical Center for Nephrotic Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: nephrotic syndrome

Genetic Tests for Nephrotic Syndrome

Genetic tests related to Nephrotic Syndrome:

# Genetic test Affiliating Genes
1 Nephrotic Syndrome 28

Anatomical Context for Nephrotic Syndrome

MalaCards organs/tissues related to Nephrotic Syndrome:

38
Kidney, T Cells, Bone, Liver, Endothelial, Testes, Thyroid

Publications for Nephrotic Syndrome

Articles related to Nephrotic Syndrome:

(show top 50) (show all 1952)
# Title Authors Year
1
Lemmings into the sea or back across the bridge? The fate of albumin in nephrotic syndrome. ( 29389392 )
2018
2
BehAset's syndrome and focal segmental glomerulosclerosis with nephrotic syndrome - successful treatment with etanercepta8c. ( 29292692 )
2018
3
Correlation Between Single-Nucleotide Polymorphisms Within miR-30a and Related Target Genes and Risk or Prognosis of Nephrotic Syndrome. ( 29356585 )
2018
4
Azithromycin suppressed relapses of idiopathic nephrotic syndrome in a child. ( 29423202 )
2018
5
Successful treatment of rituximab- and steroid-resistant nephrotic syndrome with leukocytapheresis. ( 29341230 )
2018
6
Adverse events linked with the use of chimeric and humanized anti-CD20 antibodies in children with idiopathic nephrotic syndrome. ( 29436729 )
2018
7
Successful treatment of nephrotic syndrome induced by lambda light chain deposition disease using lenalidomide: A case report andA review of the literaturea8c. ( 29393843 )
2018
8
Low birth weight is a conditioning factor for podocyte alteration and steroid dependance in children with nephrotic syndrome. ( 29350347 )
2018
9
Nephrotic syndrome complicated with femoral vein catheter-related phlegmasia cerulea dolens: A case report. ( 29436096 )
2018
10
Rivaroxaban for the treatment of venous thromboembolism in patients with nephrotic syndrome and low AT-III: A pilot study. ( 29399079 )
2018
11
Efficacy and Safety of Rituximab in Children With Steroid- and Cyclosporine-resistant and Steroid- and Cyclosporine-dependent Nephrotic Syndrome. ( 29421774 )
2018
12
Infusion reactions associated with rituximab treatment for childhood-onset complicated nephrotic syndrome. ( 29426974 )
2018
13
Nephrotic syndrome in very elderly: Should we treat aggressively? ( 29441190 )
2018
14
Levamisole in relapsing steroid-sensitive nephrotic syndrome: where do we stand? ( 29389398 )
2018
15
IL-23 Activated I^I' T Cells Affect Th17 Cells and Regulatory T Cells by Secreting IL-21 in Children with Primary Nephrotic Syndrome. ( 29119640 )
2018
16
Chlormethine Hydrochloride is Not Inferior to Tacrolimus in Treating Steroid-Resistant Nephrotic Syndrome. ( 29402844 )
2018
17
Thymoma-associated myasthenia gravis and LGI1-encephalitis, with nephrotic syndrome post-thymectomy. ( 29395322 )
2018
18
Plasma Cell Leukemia Masquerading as a Relapse of the Nephrotic Syndrome. ( 29401321 )
2018
19
Predictors of poor outcome in children with steroid sensitive nephrotic syndrome. ( 29429831 )
2018
20
Childhood nephrotic syndrome in tropical Africa: then and now. ( 28949280 )
2017
21
Case Report: A Toddler With Anasarca Caused by Congenital Nephrotic Syndrome. ( 28860961 )
2017
22
A PRISMA-compliant meta-analysis of MDR1 polymorphisms and idiopathic nephrotic syndrome: Susceptibility and steroid responsiveness. ( 28614261 )
2017
23
Cryptococcosis in Patients with Nephrotic Syndrome: A Pooled Analysis of Cases. ( 28054218 )
2017
24
Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis. ( 28776307 )
2017
25
Analysis of 24 genes reveals a monogenic cause in 11.1% of cases with steroid-resistant nephrotic syndrome at a single center. ( 28921387 )
2017
26
Characterization of NPHS2 gene polymorphisms associated to steroid resistance nephrotic syndrome in Indian children. ( 28712774 )
2017
27
Low-dose cyclosporine in treatment of membranous nephropathy with nephrotic syndrome: effectiveness and renal safety. ( 28882100 )
2017
28
Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy with Nephrotic Syndrome. ( 28090051 )
2017
29
Biochemical alteration in children with idiopathic nephrotic syndrome associated with an increased risk of sensorineural hearing loss; additional insights in cochlear renal relationship. ( 28483237 )
2017
30
Association of serum albumin level and venous thromboembolic events in a large cohort of patients with nephrotic syndrome. ( 28391310 )
2017
31
Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome. ( 28165343 )
2017
32
A Case of Nephrotic Syndrome with Thrombocytopenia, Lymphadenopathy, Systemic Inflammation, and Splenomegaly. ( 29269660 )
2017
33
Cytoplasmic Localization of WT1 and Decrease of miRNA-16-1 in Nephrotic Syndrome. ( 28299339 )
2017
34
Cavernous sinus thrombosis in a patient with nephrotic syndrome. ( 28516392 )
2017
35
Steroid-resistant nephrotic syndrome: past and current perspectives. ( 29388620 )
2017
36
Report of novel genetic variation in NPHS2 gene associated with idiopathic nephrotic syndrome in South Indian children. ( 26820844 )
2017
37
MAGI2 Mutations Cause Congenital Nephrotic Syndrome. ( 27932480 )
2017
38
Assessing responsiveness over time of the PROMIS(Ar) pediatric symptom and function measures in cancer, nephrotic syndrome, and sickle cell disease. ( 28884421 )
2017
39
Changes in DNA methylation in naA^ve T helper cells regulate the pathophysiological state in minimal-change nephrotic syndrome. ( 28915836 )
2017
40
Hereditary hyperhomocysteinemia associated with nephrotic syndrome complicated by artery thrombosis and chronic thromboembolic pulmonary hypertension: A case report. ( 29424201 )
2017
41
Nephrotic syndrome: Novel monogenic causes of Galloway-Mowat syndrome. ( 28890537 )
2017
42
Steroid-resistant nephrotic syndrome as the initial presentation of nail-patella syndrome: a case of a de novo LMX1B mutation. ( 28335748 )
2017
43
Fibroblast Growth Factor 23 (FGF23) in untreated Nephrotic syndrome. ( 28087977 )
2017
44
Zinc Responsive Acrodermatitis in Nephrotic Syndrome. ( 28584768 )
2017
45
Screening of WT1 mutations in exon 8 and 9 in children with steroid resistant nephrotic syndrome from a single centre and establishment of a rapid screening assay using high-resolution melting analysis in a clinical setting. ( 28068926 )
2017
46
Congenital Syphilis Presenting with Only Nephrotic Syndrome: Reemergence of a Forgotten Disease. ( 28665076 )
2017
47
Sclerosing thymoma-like thymic amyloidoma with nephrotic syndrome: a case report. ( 28877738 )
2017
48
Predictability of Urinary CD80 in the Relapse of Primary Nephrotic Syndrome. ( 28951877 )
2017
49
The Clinical Course of Minimal Change Nephrotic Syndrome With Onset in Adulthood or Late Adolescence: A Case Series. ( 28089478 )
2017
50
Mutation spectrum of genes associated with steroid-resistant nephrotic syndrome in Chinese children. ( 28476686 )
2017

Variations for Nephrotic Syndrome

Expression for Nephrotic Syndrome

Search GEO for disease gene expression data for Nephrotic Syndrome.

Pathways for Nephrotic Syndrome

Pathways related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.11 B2M NUP107 NUP205 NUP93
2
Show member pathways
11.43 NUP107 NUP205 NUP93
3 11.15 ACTN4 CD2AP ITGA3 LAMB2 NPHS1 NPHS2
4 10.75 CD2AP NPHS1 NPHS2
5 10.47 ACTN4 CD2AP NPHS1

GO Terms for Nephrotic Syndrome

Cellular components related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.7 ACTN4 ALB APOA1 ARHGDIA B2M CD2AP
2 endoplasmic reticulum lumen GO:0005788 9.67 ALB APOA1 B2M LAMB2
3 nuclear pore GO:0005643 9.5 NUP107 NUP205 NUP93
4 host cell GO:0043657 9.33 NUP107 NUP205 NUP93
5 slit diaphragm GO:0036057 9.26 NPHS1 NPHS2
6 nuclear periphery GO:0034399 8.8 NUP107 NUP205 NUP93

Biological processes related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.83 ALB APOA1 B2M LAMB2
2 platelet degranulation GO:0002576 9.79 ACTN4 ALB APOA1
3 viral transcription GO:0019083 9.77 NUP107 NUP205 NUP93
4 mRNA transport GO:0051028 9.76 NUP107 NUP205 NUP93
5 mRNA export from nucleus GO:0006406 9.75 NUP107 NUP205 NUP93
6 regulation of gene silencing by miRNA GO:0060964 9.73 NUP107 NUP205 NUP93
7 protein sumoylation GO:0016925 9.72 NUP107 NUP205 NUP93
8 regulation of cellular response to heat GO:1900034 9.71 NUP107 NUP205 NUP93
9 adrenal gland development GO:0030325 9.61 APOA1 WT1
10 regulation of actin cytoskeleton reorganization GO:2000249 9.61 ARHGDIA CD2AP
11 intracellular transport of virus GO:0075733 9.61 NUP107 NUP205 NUP93
12 high-density lipoprotein particle remodeling GO:0034375 9.59 ALB APOA1
13 mitotic nuclear envelope disassembly GO:0007077 9.58 NUP107 NUP205 NUP93
14 ubiquinone biosynthetic process GO:0006744 9.57 COQ6 COQ8B
15 regulation of glycolytic process GO:0006110 9.54 NUP107 NUP205 NUP93
16 blood vessel endothelial cell migration GO:0043534 9.51 APOA1 EMP2
17 glomerular basement membrane development GO:0032836 9.49 NPHS1 WT1
18 glomerular visceral epithelial cell development GO:0072015 9.48 NPHS1 NUP93
19 glomerular visceral epithelial cell differentiation GO:0072112 9.46 PTPRO WT1
20 tRNA export from nucleus GO:0006409 9.43 NUP107 NUP205 NUP93
21 regulation of glomerular filtration GO:0003093 9.32 EMP2 PTPRO
22 metanephric glomerular visceral epithelial cell development GO:0072249 9.16 LAMB2 NPHS2
23 nuclear pore complex assembly GO:0051292 9.13 NUP107 NUP205 NUP93
24 glomerulus development GO:0032835 8.8 PLCE1 PTPRO WT1

Molecular functions related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fatty acid binding GO:0005504 9.26 ALB ARHGDIA
2 integrin binding GO:0005178 9.26 ACTN4 EMP2 ITGA3 LAMB2
3 structural constituent of nuclear pore GO:0017056 8.8 NUP107 NUP205 NUP93
4 protein binding GO:0005515 10.09 ACTN4 ALB APOA1 ARHGDIA B2M CD2AP

Sources for Nephrotic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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