MCID: NPH012
MIFTS: 66

Nephrotic Syndrome malady

Nephrological diseases category

Summaries for Nephrotic Syndrome

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63Wikipedia, 32MalaCards
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Wikipedia:63 Nephrotic syndrome is a nonspecific kidney disorder characterised by a number of signs of disease:... more...

MalaCards: Nephrotic Syndrome is related to glomerulonephritis and focal segmental glomerulosclerosis. An important gene associated with Nephrotic Syndrome is NPHS2 (nephrosis 2, idiopathic, steroid-resistant (podocin)), and among its related pathways are Rho Family GTPases and Cell-cell junction organization. The drugs bendroflumethiazide and bumetanide and the compounds calcium and creatinine have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and endothelial, and related mouse phenotypes are homeostasis/metabolism and mortality/aging.

Aliases & Classifications for Nephrotic Syndrome

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 34MeSH, 27ICD9CM, 56SNOMED-CT, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

nephrotic syndrome 8 10 44 60


External Ids:

Disease Ontology8 DOID:1184
MeSH34 D009404
ICD9CM27 581
NCIt39 C34845
ICD1025 N04, N04.9

Related Diseases for Nephrotic Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Nephrotic Syndrome, Type 1 family:

Familial Nephrotic Syndrome nephrotic syndrome
Nephrotic Syndrome Type 3 Nephrotic Syndrome, Type 2
Nephrotic Syndrome, Type 4 Nephrotic Syndrome, Type 6
Nephrotic Syndrome, Type 7 Nephrotic Syndrome, Type 8
Nephrotic Syndrome, Type 9

Diseases related to Nephrotic Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 415)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis31.1ACTN4, NAGLU, CD2AP, CD79A, NPHS2, NPHS1
2focal segmental glomerulosclerosis31.1CD79A, NPHS2, NPHS1, WT1, CD2AP, NAGLU
3amyloidosis30.9F9, CD79A, ALB
4proteinuria30.8ALB, ACTN4, KIRREL, NAGLU, CD2AP, CD79A
5hepatitis30.8F9
6membranous glomerulonephritis30.7NPHS1, NPHS2, CD79A, CD2AP, ALB
7lipoid nephrosis30.6NAGLU, CD2AP, CD79A, TF, NPHS2, NPHS1
8hypertension30.6ALB, CD79A, MPV17, PPBP
9peritonitis30.5ALB
10hepatitis b30.5ALB, CD79A, F9
11hypothyroidism30.5F9
12thyroiditis30.4CD79A
13denys-drash syndrome30.4WT1
14membranoproliferative glomerulonephritis30.4CD79A, NPHS1
15arthritis30.4ALB, IL13
16nail-patella syndrome30.3NPHS2, CD2AP, LMX1B
17pyelonephritis30.3NAGLU, CD79A
18chronic pyelonephritis30.3NAGLU
19iga glomerulonephritis30.3NPHS1, NPHS2, CD79A, CD2AP, NAGLU, ALB
20frasier syndrome30.2WT1
21pancreatitis30.2ALB
22lupus erythematosus30.2CD79A
23myeloma30.2CD79A, NAGLU, IL4R, ALB
24myocardial infarction30.2F9, PPBP, NAGLU
25pneumonia30.2IL13, NAGLU, CD79A
26rheumatoid arthritis30.2PPBP, CD79A, NAGLU, IL13, IL4R
27liver cirrhosis30.2TF, ALB
28atherosclerosis30.1ALB, PPBP
29diabetic nephropathy30.0NPHS1, NPHS2, TF, NAGLU, ALB
30tuberculosis30.0CD79A, IL4R, ALB
31purpura30.0CD79A
32lung cancer30.0ALB
33chronic kidney failure29.8WT1, NPHS1, NPHS2, PPBP, TF, CD79A
34nephrosis29.8LAMB2, ACTN4, NPHS2, NPHS1
35meningitis29.8PPBP, CD79A, ALB
36schistosomiasis29.8IL13, CD79A, PPBP
37thrombocytopenia29.8ALB, CD79A, PPBP, F9
38type 2 diabetes mellitus29.8ALB, NAGLU, NPHS1, F9
39graves' disease29.8IL13, IL4R
40cystic fibrosis29.8F9, ALB
41eosinophilia29.8IL13, CD79A
42inflammatory bowel disease29.8CD79A
43bronchitis29.8CD79A
44sarcoidosis29.8IL13
45acquired immunodeficiency syndrome29.8ALB
46esophagitis29.8IL13
47diabetic retinopathy29.8NAGLU, ALB
48crohn's disease29.8ALB
49disseminated intravascular coagulation29.8F9, PPBP
50leishmaniasis29.8IL13

Graphical network of the top 20 diseases related to Nephrotic Syndrome:



Diseases related to nephrotic syndrome

Clinical Features for Nephrotic Syndrome

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Drugs & Therapeutics for Nephrotic Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Nephrotic Syndrome

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Anatomical Context for Nephrotic Syndrome

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32MalaCards
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MalaCards organs/tissues related to Nephrotic Syndrome:

32
Kidney, T cells, Endothelial, Testes, Bone, Thyroid, Liver, Lung, B cells, Monocytes, Heart, Prostate, Whole blood, Pancreas, Skin, Spinal cord, Brain, Eye, Testis, Breast, Cervix, Bone marrow

Animal Models for Nephrotic Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nephrotic Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537612.1LAMB2, ACTN4, LMX1B, PLCE1, IL4R, IL13
2MP:001076812.0F9, WT1, NPHS1, NPHS2, TF, LMX1B
3MP:000536711.8LAMB2, ALB, SMARCAL1, ACTN4, KIRREL, LMX1B
4MP:000537811.6IL4R, CD2AP, TF, MPV17, WT1, NAGLU
5MP:000538411.4CD79A, SMARCAL1, LAMB2, ACTN4, LMX1B, IL4R
6MP:000539711.4WT1, F9, NAGLU, TF, MPV17, CD79A
7MP:000538711.2CD79A, IL4R, ACTN4, LAMB2, SMARCAL1, NAGLU
8MP:000537011.0WT1, MPV17, NAGLU, IL4R, ALB, F9
9MP:000538510.9F9, MPV17, WT1, CD2AP, NAGLU, PLCE1

Publications for Nephrotic Syndrome

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50PubMed
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Articles related to Nephrotic Syndrome:

(show top 50)    (show all 1618)
idTitleAuthorsYear
1
Two dosing regimens for steroid therapy in nephrotic syndrome. (23386111)
2014
2
Profile and outcome of infantile nephrotic syndrome treated in a tertiary care center. (23354212)
2013
3
Cerebral infarction in patient with minimal change nephrotic syndrome. (23580806)
2013
4
Paraneoplastic nephrotic syndrome and inflammatory arthritis at diagnosis in Hodgkin lymphoma. (23103086)
2013
5
Carotid artery function in children with idiopathic nephrotic syndrome. (24089156)
2013
6
Patients with adult minimal change nephrotic syndrome treated with long-term cyclosporine did not experience a reduction in their eGFR. (22948120)
2013
7
Erratum to: Subclinical non-autoimmune hypothyroidism in children with steroid resistant nephrotic syndrome. (23864348)
2013
8
Lipid-lowering agents for nephrotic syndrome. (24327265)
2013
9
Successful management of factor IX inhibitor-associated nephrotic syndrome in a hemophilia B patient. (23381011)
2013
10
Mutational analysis in podocin-associated hereditary nephrotic syndrome in Polish patients: founder effect in the Kashubian population. (23645318)
2013
11
Association of neutrophil gelatinase associated lipocalin and cystatin-C with kidney function in children with nephrotic syndrome. (24049623)
2013
12
Effect of galactose on glomerular permeability and proteinuria in steroid-resistant nephrotic syndrome. (23793883)
2013
13
The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): a prospective cohort study of childhood nephrotic syndrome. (23351121)
2013
14
Steroid-resistant nephrotic syndrome associated with steroid sulfatase deficiency-x-linked recessive ichthyosis: a case report and review of literature. (22419362)
2012
15
Bronchial oncocytoma with high 18F-fluorodeoxyglucose uptake revealed by nephrotic syndrome. (22895152)
2012
16
Renal ablation using bilateral renal artery embolization for treatment of resistant nephrotic syndrome. (23168861)
2012
17
TRPC6 gene variants in Turkish children with steroid-resistant nephrotic syndrome. (21511817)
2012
18
A meta-analysis of the association between angiotensin-converting enzyme insertion/deletion gene polymorphism and steroid-sensitive nephrotic syndrome in children. (21946393)
2012
19
Unusual pediatric co-morbility: autoimmune thyroiditis and cortico-resistant nephrotic syndrome in a 6-month-old Italian patient. (23092196)
2012
20
Sperm banking in adolescent males with nephrotic syndrome: defining the limits of access to fertility preservation. (22806231)
2012
21
Neuroblastoma presenting with acute kidney injury, hyponatremic-hypertensive-like syndrome and nephrotic proteinuria in a 10-month-old child. (21941489)
2011
22
Simultaneous onset of steroid resistant nephrotic syndrome and IDDM in two young children. (22798086)
2010
23
Nephrotic syndrome in diabetic kidney disease: an evaluation and update of the definition. (19556043)
2009
24
A boy with congenital analbuminemia and steroid-sensitive idiopathic nephrotic syndrome: an experiment of nature. (17952464)
2008
25
The characteristics of relapse in adult-onset minimal-change nephrotic syndrome. (17891348)
2007
26
Interleukin-13 expression before and after pulse treatment with methylprednisolone in children with steroid-responsive nephrotic syndrome]. (18082032)
2007
27
Unexpected role of TRPC6 channel in familial nephrotic syndrome: does it have clinical implications? (16396961)
2006
28
Glomerular sclerosis in kidneys with congenital nephrotic syndrome (NPHS1). (16941028)
2006
29
A pregnant woman with nephrotic syndrome and focal segmental lesions]. (17128886)
2006
30
Varicella-induced remission of steroid-resistant nephrotic syndrome in a child. (17642785)
2004
31
Heparanase expression of peripheral blood cells in steroid responsive nephrotic syndrome patients]. (15144715)
2004
32
A case of mixed connective tissue disease presenting with nephrotic syndrome. (17143681)
2004
33
A case of antiepiligrin cicatricial pemphigoid with nephrotic syndrome. (15187343)
2004
34
Nephrotic syndrome with crescent formation and massive IgA deposition following allogeneic bone marrow transplantation for natural killer cell leukemia/lymphoma. (12543867)
2003
35
Nephrotic syndrome as a complication of anti-TNFalpha in a patient with rheumatoid arthritis. (12852723)
2003
36
Complete remission of minimal change nephrotic syndrome with type 2 diabetes mellitus treated by microemulsion formulation of cyclosporin and fluvastatin]. (11974950)
2002
37
Pregnancy outcome in nephrotic syndrome with mixed connective tissue disease. (11598404)
2001
38
Circulating VEGF and TGF-beta1 in children with idiopathic nephrotic syndrome. (11506248)
2001
39
Transcriptional and post-transcriptional alterations of IkappaBalpha in active minimal-change nephrotic syndrome. (11461937)
2001
40
Urinary RBP and glucocorticoid hormone therapy sensibility in adult primary nephrotic syndrome]. (12536664)
2001
41
Reversible nephrotic syndrome in a patient with amyloid A amyloidosis of the kidney following methicillin-resistant Staphylococcus aureus infection. (11244314)
2001
42
Does albumin preinfusion potentiate diuretic action of furosemide in patients with nephrotic syndrome? (11511790)
2001
43
Nephrotic syndrome, microcephaly, and developmental delay: three separate syndromes. (10215551)
1999
44
A case of deep vein thrombosis in idiopathic nephrotic syndrome with resistance to activated protein C. (9589377)
1998
45
Successful erythropoietin treatment for severe anemia in nephrotic syndrome without renal dysfunction. (8938689)
1996
46
Reduced natriuretic effect of atrial natriuretic peptide in nephrotic syndrome: a possible role of decreased cyclic guanosine monophosphate. (8538848)
1995
47
The effect of peripheral blood mononuclear cell products from children with nephrotic syndrome on thromboxane A2 metabolism]. (7619008)
1995
48
Efficacy of albumin and diuretic therapy in children with nephrotic syndrome. (8502517)
1993
49
Adrenocortical insufficiency and relapsing in the idiopathic nephrotic syndrome of childhood. (197476)
1977
50
Aminoaciduria in the nephrotic syndrome in children. (14482111)
1961

Genetic Variations for Nephrotic Syndrome

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Expression for genes affiliated with Nephrotic Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nephrotic Syndrome

Search GEO for disease gene expression data for Nephrotic Syndrome.

Pathways for genes affiliated with Nephrotic Syndrome

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Sources:
51QIAGEN, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems
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Compounds for genes affiliated with Nephrotic Syndrome

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Nephrotic Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 65)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.7F9, NPHS1, NPHS2, PPBP, NAGLU, IL4R
2creatinine4411.7ALB, F9, WT1, NPHS1, NPHS2, PPBP
3steroid4411.7WT1, NPHS1, NPHS2, CD79A, CD2AP, NAGLU
4tyrosine4411.6F9, WT1, NPHS1, NPHS2, PPBP, IL13
5cyclosporin a44 28 5913.6F9, WT1, NPHS2, TF, CD79A, NAGLU
6alanine4411.5F9, PPBP, TF, CD79A, NAGLU, IL13
7cysteine4411.4F9, WT1, PPBP, CD79A, NAGLU, IL13
8citrate4411.4F9, PPBP, TF, CD79A, NAGLU, ALB
9hyaluronic acid44 2412.4WT1, PPBP, CD79A, NAGLU, IL13, ALB
10heparin44 28 11 2414.4F9, PPBP, CD79A, NAGLU, IL13, LAMB2
11histamine44 28 2413.4PPBP, TF, CD79A, IL13, IL4R, ALB
12lactate4411.4PPBP, TF, CD79A, NAGLU, IL13, ALB
13thymidine44 2412.4F9, WT1, PPBP, NAGLU, IL13, IL4R
14prednisolone44 28 1113.3F9, TF, CD79A, IL13, ALB
15lipid4411.3F9, NPHS1, NPHS2, PPBP, CD2AP, NAGLU
16tacrolimus44 49 1113.3TF, CD79A, NAGLU, IL13, ALB
17dexamethasone44 49 28 1114.3F9, NPHS1, PPBP, CD79A, IL13, IL4R
18vegf4411.3WT1, NPHS1, PPBP, TF, CD79A, IL13
19fibrinogen4411.3F9, PPBP, TF, CD79A, ALB
20penicillin4411.2PPBP, TF, CD79A, IL13
21glutamine4411.2F9, WT1, TF, IL13, IL4R
22sialic acid4411.2NAGLU, CD79A, TF, F9
23puromycin aminonucleoside4411.2CD2AP, NPHS2, NPHS1
24thyroxine44 2412.2TF, CD79A, IL13, ALB
25cyclophosphamide44 49 1113.2NAGLU, TF, NPHS2
26iohexol4411.1PPBP, NAGLU, ALB
27warfarin44 49 11 2414.1CD79A, PPBP, F9
28silicone4411.1F9, PPBP, CD79A
29desmopressin44 59 28 1114.1F9, PPBP, NAGLU
30glutaraldehyde4411.1TF, CD79A, ALB
31methotrexate44 49 1113.1ALB, NAGLU, CD79A, TF
32Bismuth Subsalicylate1111.0TF, ALB
33diclofenac44 28 49 1114.0ALB, IL13, NAGLU
34iodixanol4411.0PPBP, NAGLU
35kp-10194411.0TF, ALB
36ivig4411.0F9, CD79A, ALB
37iopentol4411.0ALB, NAGLU
38p-aminohippuric acid4411.0ALB, NAGLU
39vitamin b124410.9TF, CD79A, ALB
40aluminium44 1111.9TF, NAGLU
41aspartate4410.9ALB, NAGLU
42vitamin a44 11 2412.9NAGLU
43rituximab44 49 1112.8F9, CD79A, IL13
44tween 804410.8ALB, F9
45bismuth44 2411.8ALB, TF
46allergens4410.8IL4R, IL13, CD79A
47gelfoam4410.6TF, ALB
48suprofen44 1111.6ALB, TF
49indomethacin44 59 28 1113.5ALB, IL13, CD79A, NPHS1
50ovomucoid4410.5TF

GO Terms for genes affiliated with Nephrotic Syndrome

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16Gene Ontology
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Cellular components related to Nephrotic Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1slit diaphragmGO:03605710.6NPHS2, NPHS1
2platelet alpha granule lumenGO:03109310.4ALB, ACTN4, PPBP

Biological processes related to Nephrotic Syndrome according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:00257611.0ALB, ACTN4, TF, PPBP
2glomerular basement membrane developmentGO:03283610.9MPV17, NPHS1, WT1
3platelet activationGO:03016810.8PPBP, TF, ACTN4, ALB
4excretionGO:00758810.8KIRREL, NPHS2, NPHS1
5blood coagulationGO:00759610.8F9, PPBP, TF, ACTN4, ALB
6metanephric glomerular visceral epithelial cell developmentGO:07224910.8NPHS2, LAMB2
7positive regulation of macrophage activationGO:04303210.6IL4R, IL13
8glomerulus developmentGO:03283510.3PLCE1, WT1

Products for genes affiliated with Nephrotic Syndrome

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Sources for Nephrotic Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet