MCID: NPH012
MIFTS: 59

Nephrotic Syndrome

Categories: Nephrological diseases, Genetic diseases, Blood diseases, Rare diseases, Immune diseases

Aliases & Classifications for Nephrotic Syndrome

MalaCards integrated aliases for Nephrotic Syndrome:

Name: Nephrotic Syndrome 12 29 52 42 14 69
Finnish Congenital Nephrotic Syndrome 69
Finnish Congenital Nephrosis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1184
ICD10 33 N04 N04.9
ICD9CM 35 581
MeSH 42 D009404
NCIt 47 C34845
UMLS 69 C0027726

Summaries for Nephrotic Syndrome

MalaCards based summary : Nephrotic Syndrome, also known as finnish congenital nephrotic syndrome, is related to nephrotic syndrome, type 4 and immune-complex glomerulonephritis, and has symptoms including edema An important gene associated with Nephrotic Syndrome is NPHS2 (NPHS2, Podocin), and among its related pathways/superpathways are Interferon gamma signaling and Hexose transport. The drugs Methylprednisolone and Mycophenolate mofetil have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and heart, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Nephrotic syndrome is a syndrome comprising signs of nephrosis, chiefly protein in the urine, low blood... more...

Related Diseases for Nephrotic Syndrome

Diseases in the Nephrotic Syndrome family:

Nephrotic Syndrome, Type 2 Nephrotic Syndrome 15
Nephrotic Syndrome, Type 13 Nephrotic Syndrome 14
Nephrotic Syndrome, Type 3 Nephrotic Syndrome, Type 4
Nephrotic Syndrome, Type 6 Nephrotic Syndrome, Type 11
Nephrotic Syndrome, Type 10 Nephrotic Syndrome, Type 12
Nephrotic Syndrome, Type 7 Nephrotic Syndrome, Type 8
Nephrotic Syndrome, Type 9 Nephrotic Syndrome, Type 1
Familial Nephrotic Syndrome Hereditary Nephrotic Syndromes
Hereditary Nephrotic Syndromes, Autosomal Dominant Hereditary Nephrotic Syndromes, Autosomal Recessive
Nephrotic Syndrome, Kank4-Related

Diseases related to Nephrotic Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 448)
id Related Disease Score Top Affiliating Genes
1 nephrotic syndrome, type 4 33.2 CD2AP NPHS1 NPHS2 WT1
2 immune-complex glomerulonephritis 29.8 ALB B2M
3 renal dysplasia 29.2 ARHGDIA NPHS1 NUP93 PLCE1 PTPRO WT1
4 nephrotic syndrome, type 1 12.3
5 nephrotic syndrome, type 5, with or without ocular abnormalities 12.2
6 nephrotic syndrome, type 3 12.2
7 congenital nephrotic syndrome finnish type 12.1
8 nephrotic syndrome, type 7 12.1
9 interstitial lung disease, nephrotic syndrome, and epidermolysis bullosa, congenital 12.1
10 nephrotic syndrome, type 6 12.1
11 nephrotic syndrome, type 2 12.1
12 nephrotic syndrome, type 11 12.1
13 nephrotic syndrome, type 12 12.1
14 nephrotic syndrome, type 9 12.1
15 familial nephrotic syndrome 12.0
16 nephrotic syndrome, type 8 12.0
17 nephrotic syndrome, type 13 12.0
18 nephrotic syndrome, type 10 12.0
19 pierson syndrome 11.9
20 nephrotic syndrome 14 11.9
21 focal segmental glomerulosclerosis 11.9
22 lipoid nephrosis 11.9
23 nephrotic syndrome 15 11.9
24 sporadic idiopathic steroid-resistant nephrotic syndrome with focal segmental hyalinosis 11.8
25 idiopathic steroid-sensitive nephrotic syndrome with focal segmental hyalinosis 11.8
26 hereditary nephrotic syndromes 11.8
27 galloway-mowat syndrome 11.8
28 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 11.8
29 sporadic idiopathic steroid-resistant nephrotic syndrome with minimal changes 11.8
30 sporadic idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis 11.8
31 familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis 11.8
32 familial idiopathic steroid-resistant nephrotic syndrome with minimal changes 11.8
33 familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial proliferation 11.8
34 idiopathic steroid-sensitive nephrotic syndrome with minimal change 11.8
35 idiopathic steroid-sensitive nephrotic syndrome with diffuse mesangial proliferation 11.8
36 sporadic idiopathic steroid-resistant nephrotic syndrome with collapsing glomerulopathy 11.8
37 nephrotic syndrome, idiopathic, steroid-resistant 11.8
38 leigh syndrome with nephrotic syndrome 11.7
39 steroid-resistant nephrotic syndrome, nphs2-related 11.7
40 hereditary nephrotic syndromes, autosomal dominant 11.7
41 hereditary nephrotic syndromes, autosomal recessive 11.7
42 nephrotic syndrome, kank4-related 11.7
43 nephrotic syndrome ocular anomalies 11.7
44 glomerulosclerosis, focal segmental, 1 11.7
45 coenzyme q10 deficiency, primary, 6 11.7
46 steroid-resistant nephrotic syndrome, xpo5-related 11.6
47 glomerulosclerosis, focal segmental, 4 11.6
48 membranous nephropathy 11.3
49 denys-drash syndrome 11.3
50 glomerulosclerosis, focal segmental, 6 11.3

Graphical network of the top 20 diseases related to Nephrotic Syndrome:



Diseases related to Nephrotic Syndrome

Symptoms & Phenotypes for Nephrotic Syndrome

UMLS symptoms related to Nephrotic Syndrome:


edema

MGI Mouse Phenotypes related to Nephrotic Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 PLCE1 PTPRO WT1 ACTN4 APOA1 ARHGDIA
2 homeostasis/metabolism MP:0005376 10.07 ACTN4 ALB APOA1 ARHGDIA B2M CD2AP
3 mortality/aging MP:0010768 9.93 NPHS2 WT1 MPV17 NPHS1 ACTN4 ALB
4 endocrine/exocrine gland MP:0005379 9.92 ALB APOA1 ARHGDIA B2M CD2AP ITGA3
5 renal/urinary system MP:0005367 9.36 ITGA3 LAMB2 MPV17 NPHS1 NPHS2 PTPRO
6 neoplasm MP:0002006 9.35 ALB B2M ITGA3 PLCE1 WT1

Drugs & Therapeutics for Nephrotic Syndrome

Drugs for Nephrotic Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 190)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
2
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3 128794-94-5 5281078
3
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
4
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
5
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
6
Cosyntropin Approved Phase 4 16960-16-0 16129617
7
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
8
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754 657311
9 Racepinephrine Approved Phase 4,Phase 2
10
rituximab Approved Phase 4,Phase 2,Phase 3 174722-31-7 10201696
11
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
12
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
13
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
14
Hydrochlorothiazide Approved, Vet_approved Phase 4 58-93-5 3639
15
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
16
Pravastatin Approved Phase 4,Phase 1 81093-37-0 54687
17
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
18
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 6221 10883523 5280795
19
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
20
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 11103-57-4, 68-26-8 445354
21
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
22
Alfacalcidol Approved, Nutraceutical Phase 4 41294-56-8 5282181
23 Tocopherol Approved, Nutraceutical Phase 4
24
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
25 Cyclosporins Phase 4,Phase 2
26 Heptavalent Pneumococcal Conjugate Vaccine Phase 4
27 Methylprednisolone acetate Phase 4,Phase 3,Phase 2
28 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2
29 Prednisolone acetate Phase 4,Phase 3,Phase 2
30 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2
31 Prednisolone phosphate Phase 4,Phase 3,Phase 2
32 Vaccines Phase 4
33 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
34 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2
35 glucocorticoids Phase 4,Phase 3,Phase 2
36 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
37 Hormones Phase 4,Phase 3,Phase 2,Phase 1
38 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
39 Antiemetics Phase 4,Phase 3,Phase 2
40 Autonomic Agents Phase 4,Phase 3,Phase 2
41 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
42 Neuroprotective Agents Phase 4,Phase 3
43 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
44 Protective Agents Phase 4,Phase 3
45 Cortisol succinate Phase 4
46 Epinephryl borate Phase 4,Phase 2
47 Hydrocortisone 17-butyrate 21-propionate Phase 4
48 Hydrocortisone acetate Phase 4
49 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
50 Antirheumatic Agents Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 113)

id Name Status NCT ID Phase Drugs
1 Study of 7-valent Pneumococcal Conjugate Vaccine in Children With Idiopathic Nephrotic Syndrome Unknown status NCT01346007 Phase 4
2 Low Dose Steroids in the Treatment of Nephrotic Syndrome Relapse Unknown status NCT02216747 Phase 4 prednisone 60 mg/meter square Body Surface Area;prednisone 45 mg;prednisone 30 mg
3 Long Term Tapering or Standard Steroids for Nephrotic Syndrome Unknown status NCT00308321 Phase 4 long term tapering of prednisolone;standard prednisolone treatment
4 Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test Unknown status NCT00851942 Phase 4 Synacthen (Tetracosactrin)
5 Therapeutic Effect of Tacrolimus on Primary Nephrotic Syndrome in Children Completed NCT01162005 Phase 4 Tacrolimus
6 Mycophenolate Mofetil in Pediatric Steroid Dependent Nephrotic Syndrome Completed NCT01895894 Phase 4 Mycophenolate mofetil
7 Treatment of Resistant Nephrotic Syndrome With ACTH Gel (ACTHAR) Completed NCT01129284 Phase 4 ACTHAR gel
8 Urinary Aquaporin 2 and Expression of the NPHS2 Gene in Adults Suffering From Nephrotic Syndrome Completed NCT00286910 Phase 4
9 A Study to Evaluate the Effect of Tacrolimus and Corticosteroid Combination Therapy in Patients With Minimal Change Nephrotic Syndrome Completed NCT01763580 Phase 4 Tacrolimus;Prednisolone
10 Prospective Study Evaluating the Effect of Repository Corticotropin in the Treatment of Various Nephrotic Syndromes Completed NCT01021540 Phase 4 Repository corticotrophin
11 Role of Acetazolamide and Hydrochlorothiazide Followed by Furosemide in Treating Nephrotic Edema Completed NCT02427880 Phase 4 Acetazolamide and Hydrochlorothiazide Followed by Furosemide;Furosemide and Hydrochlorothiazide Followed by Furosemide
12 Acthar for Treatment of Proteinuria in Membranous Nephropathy Patients Completed NCT01386554 Phase 4 Repository Corticotropin Injection;Placebo
13 Adrenocorticotropic Hormone (ACTH) Treatment of Nephrotic Range Proteinuria in Diabetic Nephropathy (NRDN) Completed NCT01028287 Phase 4 ACTH;ACTH
14 HSP-glomerulonephritis Trial: MP vs CyA Completed NCT00425724 Phase 4 Methylprednisolone pulses plus prednisone versus Cyclosporine A
15 Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Resistant Nephrotic Syndrome Recruiting NCT02382575 Phase 4 Rituximab;Tacrolimus
16 Myfortic® for Minimal Change Nephrotic Syndrome (MCNS): a Randomized Study Recruiting NCT01185197 Phase 4 Myfortic plus low-dose steroid;Prednisolone
17 Tacrolimus Versus Prednisolone for the Treatment of Minimal Change Disease Recruiting NCT00982072 Phase 4 tacrolimus;prednisolone
18 Tacrolimus Combined With Entecavir on HBV Associated Glomerulonephritis(HBV-GN) Recruiting NCT03062813 Phase 4 Tacrolimus &entecavir;placebo & entecavir
19 Efficacy of Usual Vitamin D Supplementation and Its Impact on Children and Adolescents Calciuria. Recruiting NCT02238418 Phase 4 Cholecalciferol vial (100 000 UI)
20 Mycophenolate Mofetil Plus Steroid in the Treatment Of Patients With Progressive Idiopathic Membranous Nephropathy Recruiting NCT03170323 Phase 4 Mycophenolate Mofetil;Cyclosporins
21 Mycophenolate Mofetil and Tacrolimus Versus Tacrolimus for the Treatment of Idiopathic Membranous Glomerulonephritis (IMG) Active, not recruiting NCT00843856 Phase 4 tacrolimus;tacrolimus and mycophenolate mofetil
22 Adjusted Steroids Therapy in Childerens With Idiopathic Nephrotic Syndrome Not yet recruiting NCT02649413 Phase 4 Prednisone
23 Active Vitamin D And Reduced Dose Prednisolone for Treatment in Minimal Change Nephropathy Not yet recruiting NCT03210688 Phase 4 Prednisolone;Alfacalcidol
24 Anti-Oxidant Therapy In Chronic Renal Insufficiency (ATIC) Study Terminated NCT00384618 Phase 4 pravastatin;vitamin E
25 Rituximab Trial for Pediatric Nephrotic Syndrome Unknown status NCT01716442 Phase 2, Phase 3 Rituximab;Placebo
26 Efficacy of Pentoxifylline on Primary Nephrotic Syndrome Completed NCT00354731 Phase 3 pentoxifylline;Corticosteroid
27 Efficacy of Rituximab For the Treatment of Calcineurin Inhibitors Dependent Nephrotic Syndrome During Childhood Completed NCT01268033 Phase 2, Phase 3 Rituximab;Placebo
28 Cyclophosphamide Versus Mycophenolate Mofetil for the Treatment of Steroid-dependent Nephrotic Syndrome in Children Completed NCT01092962 Phase 3 Cyclophosphamide;Mycophenolate mofetil
29 Evaluation of Low Dose Corticosteroids Efficiency, Associated With Myfortic ® in the Treatment of Nephrotic Syndrome Completed NCT01197040 Phase 3 Prednisone;acid mycophenolic (Myfortic)
30 Efficacy and Safety of Rituximab to That of Calcineurin Inhibitors in Children With Steroid Dependent Nephrotic Syndrome Completed NCT02438982 Phase 3 Tacrolimus;Rituximab
31 The Efficacy and Tolerance of Tacrolimus Sustained-release Capsules on Refractory Nephrotic Syndrome (RNS) Completed NCT01309477 Phase 3 Tacrolimus Sustained-release Capsules (ADVAGRAF)
32 Tacrolimus Combined With Prednisone Treatment of Idiopathic Membranous Nephropathy and Nephrotic Syndrome Completed NCT00362531 Phase 2, Phase 3 tacrolimus combined with prednisone
33 Prospective, Multicenter Study of the Efficacy and Tolerance of Tacrolimus on Refractory Nephrotic Syndrome (RNS) Completed NCT00615667 Phase 3 tacrolimus (FK506)
34 Rituximab in Multirelapsing Minimal Change Disease (MCD) or Focal Segmental Glomerulosclerosis (FSGS) Completed NCT00981838 Phase 3 Rituximab
35 Steroid Treatment for Kidney Disease Completed NCT00065611 Phase 3 Oral dexamethasone
36 Study of the Safety and Efficacy of NC-503 in Secondary (AA) Amyloidosis Completed NCT00035334 Phase 2, Phase 3 NC-503 (Anti-amyloidotic (AA) Agent)
37 Rituximab in Membranous Nephropathy Completed NCT00425217 Phase 2, Phase 3 Rituximab
38 Therapeutic Effect of Tacrolimus in Combination With Low Dose Corticosteroid in Adult Patient With Minimal Change Nephritic Syndrome Completed NCT01084980 Phase 2, Phase 3 Tacrolimus
39 Adrenocorticotropic Hormone (ACTH) for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome Recruiting NCT02132195 Phase 3 ACTH
40 A Study to Evaluate the Efficacy and Safety of Mizoribine in the Treatment of Refractory Nephrotic Syndrome Recruiting NCT02257697 Phase 3 Mizoribine (MZR);Cyclophosphamide (CTX)
41 Prednisolone Trial in Children Younger Than 4 Years Recruiting NCT03141970 Phase 3 Prednisolone
42 Valproic Acid for Idiopathic Nephrotic Syndrome Recruiting NCT02896270 Phase 2, Phase 3 Valproic Acid
43 Rituximab Versus Steroids and Cyclophosphamide in the Treatment of Idiopathic Membranous Nephropathy Recruiting NCT03018535 Phase 3 Rituximab;Methylprednisolone;Cyclophosphamide
44 Evaluate Rituximab Treatment for Idiopathic Membranous Nephropathy Active, not recruiting NCT01508468 Phase 3 symptomatic treatment (Converting Enzyme inhibitor, Angiotensin II, Anti-renin, Aldosterone antagonist diuretic, Beta blocker, Calcium inhibitor, statin);experimental (Non Immunosuppressive Symptomatic Treatment (NIST) and Rituximab)
45 Efficiency of Levamisole for Maintaining Remission After the First Flare of Steroid Sensitive Nephrotic Syndrome in Children Not yet recruiting NCT02818738 Phase 3 Levamisole Hydrochloride
46 Efficacy of Rituximab in Comparison to Continued Corticosteroid Treatment in Idiopathic Nephrotic Syndrome Not yet recruiting NCT03298698 Phase 3 Rituximab;Prednisone
47 Randomized Trial Comparing Rituximab Against Mycophenolate Mofetil in Children Wtih Refractory Nephrotic Syndrome Terminated NCT02390362 Phase 3 Rituximab;MMF
48 IL-2 for Multi Drug Resistant Nephrotic Syndrome Completed NCT02455908 Phase 1, Phase 2 Proleukin®
49 Drug Therapy in Lupus Nephropathy Completed NCT00001212 Phase 2 prednisone;cyclophosphamide;cyclosporin A
50 Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis Completed NCT00004990 Phase 2 Dexamethasone

Search NIH Clinical Center for Nephrotic Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: nephrotic syndrome

Genetic Tests for Nephrotic Syndrome

Genetic tests related to Nephrotic Syndrome:

id Genetic test Affiliating Genes
1 Nephrotic Syndrome 29

Anatomical Context for Nephrotic Syndrome

MalaCards organs/tissues related to Nephrotic Syndrome:

39
Kidney, Lung, Heart, Testes, Bone, T Cells, Liver

Publications for Nephrotic Syndrome

Articles related to Nephrotic Syndrome:

(show top 50) (show all 1921)
id Title Authors Year
1
Analysis of 24 genes reveals a monogenic cause in 11.1% of cases with steroid-resistant nephrotic syndrome at a single center. ( 28921387 )
2017
2
Klippel-Trenaunay-Weber syndrome with atypical presentation of hypersplenism and nephrotic syndrome: a case report. ( 28823249 )
2017
3
Screening of WT1 mutations in exon 8 and 9 in children with steroid resistant nephrotic syndrome from a single centre and establishment of a rapid screening assay using high-resolution melting analysis in a clinical setting. ( 28068926 )
2017
4
Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. ( 28805828 )
2017
5
Galloway-mowat syndrome - unusual form of nephrotic syndrome in adolescent. ( 28937085 )
2017
6
The Clinical Course of Minimal Change Nephrotic Syndrome With Onset in Adulthood or Late Adolescence: A Case Series. ( 28089478 )
2017
7
Sclerosing thymoma-like thymic amyloidoma with nephrotic syndrome: a case report. ( 28877738 )
2017
8
A PRISMA-compliant meta-analysis of MDR1 polymorphisms and idiopathic nephrotic syndrome: Susceptibility and steroid responsiveness. ( 28614261 )
2017
9
Corticosteroids Therapy for Paraneoplastic Nephrotic Syndrome. ( 28885235 )
2017
10
Acute myocardial infarction in patients of nephrotic syndrome: a case series. ( 28868077 )
2017
11
Multidimensional impact on families of children with steroid-sensitive nephrotic syndrome. ( 28058746 )
2017
12
Report of novel genetic variation in NPHS2 gene associated with idiopathic nephrotic syndrome in South Indian children. ( 26820844 )
2017
13
A Drosophila model system to assess the function of human monogenic podocyte mutations that cause nephrotic syndrome. ( 28164240 )
2017
14
A Case of Compartment Syndrome in the Scrotum and Inguinal Area Complicating Idiopathic Nephrotic Syndrome of Childhood. ( 28856105 )
2017
15
Genetic basis of adult-onset nephrotic syndrome and focal segmental glomerulosclerosis. ( 28776307 )
2017
16
Correlation Between Idiopathic Nephrotic Syndrome and Atopy in Children - Short Review. ( 28878838 )
2017
17
Case Report: A Toddler With Anasarca Caused by Congenital Nephrotic Syndrome. ( 28860961 )
2017
18
Management of Nephrotic Syndrome: A Case Report from Lao PDR. ( 28869958 )
2017
19
Spontaneous evisceration of umbilical hernia in a patient with congenital nephrotic syndrome. ( 28507377 )
2017
20
Changes in DNA methylation in naA^ve T helper cells regulate the pathophysiological state in minimal-change nephrotic syndrome. ( 28915836 )
2017
21
Glomerular Glucocorticoid Receptors Expression and Clinicopathological Types of Childhood Nephrotic Syndrome. ( 27690709 )
2017
22
Nephrotic syndrome: Novel monogenic causes of Galloway-Mowat syndrome. ( 28890537 )
2017
23
Assessing responsiveness over time of the PROMIS(Ar) pediatric symptom and function measures in cancer, nephrotic syndrome, and sickle cell disease. ( 28884421 )
2017
24
Cost analysis on the use of rituximab and calcineurin inhibitors in children and adolescents with steroid-dependent nephrotic syndrome. ( 28864927 )
2017
25
Cryptococcosis in Patients with Nephrotic Syndrome: A Pooled Analysis of Cases. ( 28054218 )
2017
26
Zinc Responsive Acrodermatitis in Nephrotic Syndrome. ( 28584768 )
2017
27
A Case of the nephrotic syndrome in bone marrow transplantation recipient, histologically showing overlapped glomerular lesions of thrombotic microangiopathy and membranous nephropathy. ( 28940837 )
2017
28
Long-term repeated rituximab treatment for childhood steroid-dependent nephrotic syndrome. ( 28904877 )
2017
29
Steroid-resistant nephrotic syndrome as the initial presentation of nail-patella syndrome: a case of a de novo LMX1B mutation. ( 28335748 )
2017
30
Biochemical alteration in children with idiopathic nephrotic syndrome associated with an increased risk of sensorineural hearing loss; additional insights in cochlear renal relationship. ( 28483237 )
2017
31
Fibroblast Growth Factor 23 (FGF23) in untreated Nephrotic syndrome. ( 28087977 )
2017
32
Nephrotic Syndrome in Small Cell Lung Cancer and Induction of C-Mip in Podocytes. ( 28063735 )
2017
33
Cavernous sinus thrombosis in a patient with nephrotic syndrome. ( 28516392 )
2017
34
Difficult-to-treat idiopathic nephrotic syndrome: established drugs, open questions and future options. ( 28879428 )
2017
35
Low-dose cyclosporine in treatment of membranous nephropathy with nephrotic syndrome: effectiveness and renal safety. ( 28882100 )
2017
36
Diabetes and nephrotic syndrome: Questions. ( 28074283 )
2017
37
Nephrotic syndrome in infants and children: pathophysiology and management. ( 28914167 )
2017
38
Mutation spectrum of genes associated with steroid-resistant nephrotic syndrome in Chinese children. ( 28476686 )
2017
39
Congenital Syphilis Presenting with Only Nephrotic Syndrome: Reemergence of a Forgotten Disease. ( 28665076 )
2017
40
MAGI2 Mutations Cause Congenital Nephrotic Syndrome. ( 27932480 )
2017
41
Childhood nephrotic syndrome in tropical Africa: then and now. ( 28949280 )
2017
42
Different Effects of Tolvaptan in Patients with Idiopathic Membranous Nephropathy with Nephrotic Syndrome. ( 28090051 )
2017
43
Nephrotic syndrome associated with metastatic thymoma treated with chemotherapy. ( 28072685 )
2017
44
Further phenotypic heterogeneity of CoQ10 deficiency associated with Steroid Resistant Nephrotic Syndrome and novel COQ2 and COQ6 variants. ( 28044327 )
2017
45
Characteristics of lipid metabolism including serum apolipoprotein M levels in patients with primary nephrotic syndrome. ( 28877724 )
2017
46
Late Onset Cobalamin Disorder and Hemolytic Uremic Syndrome: A Rare Cause of Nephrotic Syndrome. ( 28835862 )
2017
47
Cytoplasmic Localization of WT1 and Decrease of miRNA-16-1 in Nephrotic Syndrome. ( 28299339 )
2017
48
Predictability of Urinary CD80 in the Relapse of Primary Nephrotic Syndrome. ( 28951877 )
2017
49
Elevated Urinary Levels of 8-Hydroxy-2'-deoxyguanosine in a Japanese Child of Xeroderma Pigmentosum/Cockayne Syndrome Complex with Infantile Onset of Nephrotic Syndrome. ( 27396511 )
2016
50
Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome. ( 26878725 )
2016

Variations for Nephrotic Syndrome

Expression for Nephrotic Syndrome

Search GEO for disease gene expression data for Nephrotic Syndrome.

Pathways for Nephrotic Syndrome

Pathways related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.11 B2M NUP107 NUP205 NUP93
2
Show member pathways
11.43 NUP107 NUP205 NUP93
3 11.15 ACTN4 CD2AP ITGA3 LAMB2 NPHS1 NPHS2
4 10.75 CD2AP NPHS1 NPHS2
5 10.47 ACTN4 CD2AP NPHS1

GO Terms for Nephrotic Syndrome

Cellular components related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.7 ACTN4 ALB APOA1 ARHGDIA B2M CD2AP
2 endoplasmic reticulum lumen GO:0005788 9.62 ALB APOA1 B2M LAMB2
3 nuclear pore GO:0005643 9.43 NUP107 NUP205 NUP93
4 slit diaphragm GO:0036057 9.16 NPHS1 NPHS2
5 nuclear periphery GO:0034399 8.8 NUP107 NUP205 NUP93

Biological processes related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

(show all 23)
id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.8 ALB APOA1 B2M LAMB2
2 platelet degranulation GO:0002576 9.79 ACTN4 ALB APOA1
3 viral transcription GO:0019083 9.77 NUP107 NUP205 NUP93
4 mRNA transport GO:0051028 9.77 NUP107 NUP205 NUP93
5 mRNA export from nucleus GO:0006406 9.74 NUP107 NUP205 NUP93
6 regulation of gene silencing by miRNA GO:0060964 9.72 NUP107 NUP205 NUP93
7 protein sumoylation GO:0016925 9.71 NUP107 NUP205 NUP93
8 regulation of cellular response to heat GO:1900034 9.7 NUP107 NUP205 NUP93
9 adrenal gland development GO:0030325 9.61 APOA1 WT1
10 intracellular transport of virus GO:0075733 9.61 NUP107 NUP205 NUP93
11 high-density lipoprotein particle remodeling GO:0034375 9.58 ALB APOA1
12 regulation of actin cytoskeleton reorganization GO:2000249 9.58 ARHGDIA CD2AP
13 mitotic nuclear envelope disassembly GO:0007077 9.58 NUP107 NUP205 NUP93
14 ubiquinone biosynthetic process GO:0006744 9.56 COQ6 COQ8B
15 tRNA export from nucleus GO:0006409 9.54 NUP107 NUP205 NUP93
16 blood vessel endothelial cell migration GO:0043534 9.51 APOA1 EMP2
17 glomerular visceral epithelial cell development GO:0072015 9.48 NPHS1 NUP93
18 glomerular visceral epithelial cell differentiation GO:0072112 9.46 PTPRO WT1
19 nuclear pore complex assembly GO:0051292 9.33 NUP107 NUP205 NUP93
20 regulation of glomerular filtration GO:0003093 9.32 EMP2 PTPRO
21 metanephric glomerular visceral epithelial cell development GO:0072249 9.26 LAMB2 NPHS2
22 glomerular basement membrane development GO:0032836 9.13 MPV17 NPHS1 WT1
23 glomerulus development GO:0032835 8.8 PLCE1 PTPRO WT1

Molecular functions related to Nephrotic Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.26 ACTN4 EMP2 ITGA3 LAMB2
2 fatty acid binding GO:0005504 9.16 ALB ARHGDIA
3 structural constituent of nuclear pore GO:0017056 8.8 NUP107 NUP205 NUP93

Sources for Nephrotic Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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