MCID: NRV006
MIFTS: 45

Nervous System Cancer malady

Neuronal diseases, Cancer diseases categories

Summaries for Nervous System Cancer

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 An organ system cancer located in the nervous sytem that affects the central or peripheral nervous system.

MalaCards: Nervous System Cancer, also known as neuroepithelial, perineurial, and schwann cell neoplasm, is related to central nervous system cancer and brain cancer. An important gene associated with Nervous System Cancer is ARSA (arylsulfatase A). The compounds askin and taurine have been mentioned in the context of this disorder. Affiliated tissues include the nervous sytem, breast and brain, and related mouse phenotypes are taste/olfaction and hematopoietic system.

Wikipedia:63 A nervous system neoplasm is a tumor affecting the nervous system. Types include: more...

Aliases & Classifications for Nervous System Cancer

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

nervous system cancer 8
neuroepithelial, perineurial, and schwann cell neoplasm 60
malignant neoplasm of nervous system 8
tumor of the nervous system 8
neoplasm of nervous system 8
nervous system neoplasms 60
nervous system neoplasm 8
nervous system tumor 44
neural neoplasm 8
neural tumor 8


External Ids:

Disease Ontology8 DOID:3093
SNOMED-CT56 188306000
MeSH34 D009380

Related Diseases for Nervous System Cancer

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Central Nervous System Cancer family:

nervous system cancer

Diseases related to Nervous System Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1central nervous system cancer30.8ARSA, ENO2
2brain cancer30.3CASP3, GAL, SHH, ENO2
3leukemia30.2CASP3, CD99, FLI1, EWSR1, GAL
4neuroblastoma30.0ENO2
5medulloblastoma29.9ENO2, CASP3, SHH
6melanoma29.9GAL, EWSR1, FLI1, ENO2, CASP3
7ganglioneuroma29.8ENO2, GAL
8rhabdomyosarcoma29.8EWSR1, FLI1, ENO2, CD99
9autonomic nervous system neoplasm10.2
10central nervous system leukemia10.1
11neuronitis10.1
12childhood leukemia10.1
13ectomesenchymoma10.1
14central neurocytoma10.1
15olfactory neural tumor10.1
16neuroma10.1
17choroid plexus papilloma10.0
18central nervous system hematologic cancer10.0
19encephalomyelitis10.0
20spinal cancer10.0
21glioma somatic10.0
22esophageal atresia10.0SHH
23krabbe disease10.0ARSA
24fibrous histiocytoma10.0EWSR1
25anaplastic large cell lymphoma10.0ENO2
26gastrointestinal stromal tumor10.0ENO2
27granular cell tumor10.0ENO2
28gastrinoma10.0ENO2
29arthritis10.0GAL
30parkinson's disease10.0SHH
31extraskeletal ewing sarcoma10.0EWSR1, CD99
32osteosarcoma10.0CASP3
33connective tissue benign neoplasm10.0EWSR1, FLI1
34liposarcoma10.0FLI1, EWSR1
35down syndrome10.0GAL, ARSA
36dementia10.0ARSA, GAL
37diabetes mellitus10.0CASP3
38chondrosarcoma10.0ENO2, EWSR1
39hepatitis10.0GAL, CD99
40adenoma10.0GAL, ENO2
41colon adenocarcinoma10.0CASP3
42stomach cancer10.0CD99, CASP3
43synovial sarcoma10.0FLI1, EWSR1, CD99
44olfactory neuroblastoma10.0CD99, FLI1, ENO2
45lymphoblastic lymphoma10.0CD99, ENO2, FLI1
46retinoblastoma10.0ENO2, CASP3
47neuroepithelioma10.0FLI1, ENO2, EWSR1
48wilms tumor10.0ENO2, EWSR1, FLI1
49neuroendocrine tumor10.0GAL, ENO2
50ischemia10.0GAL, CASP3

Graphical network of the top 20 diseases related to Nervous System Cancer:



Diseases related to nervous system cancer

Clinical Features for Nervous System Cancer

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Drugs & Therapeutics for Nervous System Cancer

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Nervous System Cancer

Drug clinical trials:

Search ClinicalTrials for Nervous System Cancer

Search NIH Clinical Center for Nervous System Cancer

Search CenterWatch for Nervous System Cancer

Genetic Tests for Nervous System Cancer

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Anatomical Context for Nervous System Cancer

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Nervous System Cancer:

32
Breast, Brain, Lung, Liver, Endothelial, Pancreas

FMA organs/tissues related to Nervous System Cancer:

14
The nervous sytem

Animal Models for Nervous System Cancer or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Nervous System Cancer:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.1CASP3, SHH, ENO2
2MP:00053978.0EWSR1, SHH, FLI1, ARSA, CASP3
3MP:00036317.3ENO2, SHH, FLI1, ARSA, GAL, CASP3
4MP:00053847.1ENO2, EWSR1, SHH, FLI1, GAL, CASP3

Publications for Nervous System Cancer

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50PubMed
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Articles related to Nervous System Cancer:

(show top 50)    (show all 54)
idTitleAuthorsYear
1
LDL Receptor-Related Protein-1: A Regulator of Inflammation in Atherosclerosis, Cancer, and Injury to the Nervous System. (24128688)
2014
2
The Central Nervous System as a Sanctuary Site in ALK-Positive Non-Small-Cell Lung Cancer. (24389440)
2013
3
Beneath the Blood Brain Barrier: The Challenge of Diagnosis and Management of Central Nervous System Involvement in ALK-Positive Lung Cancer. (24389428)
2013
4
Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients. (23661397)
2013
5
Retrospective analysis of risk factors for central nervous system metastases in operable breast cancer: effects of biologic subtype and Ki67 overexpression on survival. (23235554)
2013
6
Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors. (21974969)
2012
7
Characteristic of galaninergic components of the enteric nervous system in the cancer invasion of human large intestine. (22226150)
2012
8
Medulloblastoma and Brucellosis - Molecular Evidence of Brucella sp in Association with Central Nervous System Cancer. (21475718)
2011
9
Comparison of time trends in brain and central nervous system cancer mortality (1990-2006) between countries based on the WHO mortality database. (21273379)
2011
10
Influence of 6q22-23 on overall survival in primary central nervous system lymphoma. Analysis of North Central Cancer Treatment Group trials 86 72 52, 93 73 51 and 96 73 51. (21275973)
2011
11
Development of central nervous system metastases in patients with advanced non-small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib. (21030498)
2010
12
Long-term health experience of jet engine manufacturing workers: IV. A comparison of central nervous system cancer ascertainment using mortality and incidence data. (20816315)
2010
13
Pain in children with central nervous system cancer: a review of the literature. (20591796)
2010
14
Characteristics and outcomes of elderly patients with primary central nervous system lymphoma: the Memorial Sloan-Kettering Cancer Center experience. (20572045)
2010
15
School-aged children after the end of successful treatment of non-central nervous system cancer: longitudinal assessment of health-related quality of life, anxiety and coping. (19594611)
2009
16
Differential N-glycosylation of kallikrein 6 derived from ovarian cancer cells or the central nervous system. (19088065)
2009
17
Human epidermal growth factor receptor 2-positive breast cancer and central nervous system metastases. (19770385)
2009
18
An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016). (19056914)
2009
19
Comparison of time trends in brain central nervous system cancer incidence (1973-97) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vols IV-VIII. (18772173)
2008
20
Molecular predictors of human nervous system cancer responsiveness to enediyne chemotherapy. (18338171)
2008
21
Neuropsychological sequelae of non-central nervous system cancer and cancer therapy. (18415683)
2008
22
Risk factors for central nervous system metastasis in patients with metastatic breast cancer. (17848738)
2007
23
Whole-brain radiotherapy and high-dose methylprednisolone for elderly patients with primary central nervous system lymphoma: Results of North Central Cancer Treatment Group (NCCTG) 96-73-51. (16863926)
2006
24
Primary central nervous system lymphoma: the Memorial Sloan-Kettering Cancer Center prognostic model. (17116938)
2006
25
The treatment of primary central nervous system lymphoma in 122 immunocompetent patients: a population-based study of successively treated cohorts from the British Colombia Cancer Agency. (15651059)
2005
26
Central nervous system metastases in breast cancer patients administered trastuzumab. (15979804)
2005
27
Epidermal growth factor receptor status in breast cancer metastases to the central nervous system. Comparison with HER-2/neu status. (15335267)
2004
28
Cytotoxicity and oncostatic activity of the thiazolidinedione derivative CGP 52608 on central nervous system cancer cells. (15194216)
2004
29
Central nervous system listeriosis confused with leptomeningeal carcinomatosis in cancer patients. (15057164)
2004
30
Pyridoxal phosphatase is a novel cancer autoantigen in the central nervous system. (15452547)
2004
31
Occult central nervous system involvement in patients with metastatic breast cancer: prevalence, predictive factors and impact on overall survival. (12853349)
2003
32
Her-2/neu status in breast cancer metastases to the central nervous system. (14567724)
2003
33
High-dose methotrexate-based chemotherapy followed by consolidating radiotherapy in non-AIDS-related primary central nervous system lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962. (14597741)
2003
34
German Cancer Society Neuro-Oncology Working Group NOA-03 multicenter trial of single-agent high-dose methotrexate for primary central nervous system lymphoma. (11835382)
2002
35
Immunogenetic characteristics of patients with stomach cancer and predominant activity of either sympathetic or parasympathetic autonomic nervous system. (11013848)
2000
36
Nervous system cancer mortality in an industrialized area of Brazil 1980-1993. (10920400)
2000
37
Exploitation of immune mechanisms in the treatment of central nervous system cancer. (10914414)
2000
38
HIP/PAP gene, encoding a C-type lectin overexpressed in primary liver cancer, is expressed in nervous system as well as in intestine and pancreas of the postimplantation mouse embryo. (10329612)
1999
39
Endocrine mechanism of action of toremifene at the level of the central nervous system in advanced breast cancer patients. (9685060)
1998
40
Stiff-man syndrome in a woman with breast cancer: an uncommon central nervous system paraneoplastic syndrome. (9443464)
1998
41
Detection of membrane-associated human chorionic gonadotropin and its subunits on human cultured cancer cells of the nervous system. (9232319)
1997
42
Risk of nervous system cancer among workers exposed to lead. (8673517)
1996
43
Intermediate filaments in the nervous system: implications in cancer. (9034605)
1996
44
Craniospinal irradiation for acute lymphoblastic leukemia with central nervous system disease at diagnosis: a report from the Children's Cancer Group. (8823255)
1996
45
Diagnostic value of cerebrospinal fluid cytology in comparison with tumor marker activity in central nervous system metastases secondary to breast cancer. (8402452)
1993
46
Human malignant astrocytoma xenografts migrate in rat brain: a model for central nervous system cancer research. (2651679)
1989
47
Human retrovirus family: cancer, central nervous system disease, and AIDS. (2842514)
1988
48
Asbestosis, the nervous system and cancer. (6497337)
1984
49
Brain and central nervous system cancer mortality in U. S. rubber workers. (6953785)
1982
50
The remote effects of cancer on the nervous system: cerebellar degeneration. (889453)
1977

Genetic Variations for Nervous System Cancer

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Expression for genes affiliated with Nervous System Cancer

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nervous System Cancer

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Pathways for genes affiliated with Nervous System Cancer

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Compounds for genes affiliated with Nervous System Cancer

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Sources:
44Novoseek, 59Tocris Bioscience, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB
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Compounds related to Nervous System Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1askin449.8EWSR1, ENO2
2taurine44 59 2411.6ENO2, GAL
3octreotide44 59 28 1112.5GAL, ENO2
4serine449.4GAL, EWSR1, ARSA
5etoposide44 49 59 1112.1CASP3, GAL, ENO2
6phosphatidylserine44 28 1111.1CD99, GAL, CASP3
7glutamine448.9EWSR1, ARSA, ENO2
8paraffin448.8CD99, EWSR1, ENO2
9oligonucleotide448.6EWSR1, GAL, ARSA, FLI1
10retinoic acid44 249.6GAL, ENO2, EWSR1, CASP3

GO Terms for genes affiliated with Nervous System Cancer

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16Gene Ontology
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Cellular components related to Nervous System Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.7ENO2, CD99, SHH, ARSA, EWSR1, CASP3

Molecular functions related to Nervous System Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:0082339.6SHH, CASP3

Products for genes affiliated with Nervous System Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nervous System Cancer

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet