MCID: NRV006
MIFTS: 38

Nervous System Cancer malady

Summaries for Nervous System Cancer

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 An organ system cancer located in the nervous sytem that affects the central or peripheral nervous system.

MalaCards: Nervous System Cancer, also known as neuroepithelial, perineurial, and schwann cell neoplasm, is related to brain cancer and ganglioneuroma. An important gene associated with Nervous System Cancer is ARSA (arylsulfatase A). The compounds askin and taurine have been mentioned in the context of this disorder. Affiliated tissues include the nervous sytem, and related mouse phenotypes are taste/olfaction and hematopoietic system.

Wikipedia:64 A nervous system neoplasm is a tumor affecting the nervous system. Types include: more...

Aliases & Classifications for Nervous System Cancer

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

nervous system cancer 8
neuroepithelial, perineurial, and schwann cell neoplasm 61
malignant neoplasm of nervous system 8
tumor of the nervous system 8
neoplasm of nervous system 8
nervous system neoplasms 61
nervous system neoplasm 8
nervous system tumor 45
neural neoplasm 8
neural tumor 8


External Ids:

Disease Ontology8 DOID:3093
SNOMED-CT57 188306000
MeSH35 D009380

Related Diseases for Nervous System Cancer

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the central nervous system cancer family:

nervous system cancer

Diseases related to Nervous System Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1brain cancer30.5CASP3, GAL, SHH, ENO2
2ganglioneuroma29.8ENO2, GAL
3wilms tumor29.8ENO2, EWSR1, FLI1
4autonomic nervous system neoplasm10.3
5central nervous system leukemia10.2
6ectomesenchymoma10.2
7olfactory neural tumor10.1
8choroid plexus papilloma10.1
9central nervous system hematologic cancer10.1
10spinal cancer10.1
11glioma somatic10.1
12astrocytoma10.0
13neurofibromatosis10.0
14tuberous sclerosis10.0
15hyperprolactinemia10.0
16ganglioglioma10.0
17familial melanoma10.0
18pleomorphic xanthoastrocytoma10.0
19mowat-wilson syndrome10.0
20turcot syndrome10.0
21pilocytic astrocytoma10.0
22pituitary tumors10.0
23esophageal atresia10.0SHH
24krabbe disease10.0ARSA
25fibrous histiocytoma10.0EWSR1
26anaplastic large cell lymphoma10.0ENO2
27gastrointestinal stromal tumor10.0ENO2
28neuroblastoma10.0ENO2
29granular cell tumor10.0ENO2
30gastrinoma10.0ENO2
31arthritis10.0GAL
32parkinson's disease10.0SHH
33central nervous system cancer10.0ARSA, ENO2
34extraskeletal ewing sarcoma10.0EWSR1, CD99
35osteosarcoma10.0CASP3
36connective tissue benign neoplasm10.0EWSR1, FLI1
37liposarcoma10.0FLI1, EWSR1
38down syndrome10.0GAL, ARSA
39dementia10.0ARSA, GAL
40diabetes mellitus10.0CASP3
41chondrosarcoma10.0ENO2, EWSR1
42hepatitis10.0GAL, CD99
43adenoma10.0GAL, ENO2
44colon adenocarcinoma10.0CASP3
45stomach cancer10.0CD99, CASP3
46synovial sarcoma10.0FLI1, EWSR1, CD99
47olfactory neuroblastoma10.0CD99, FLI1, ENO2
48lymphoblastic lymphoma10.0CD99, ENO2, FLI1
49retinoblastoma10.0ENO2, CASP3
50neuroepithelioma10.0FLI1, ENO2, EWSR1

Graphical network of the top 20 diseases related to Nervous System Cancer:



Diseases related to nervous system cancer

Clinical Features for Nervous System Cancer

Drugs & Therapeutics for Nervous System Cancer

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Nervous System Cancer

Drug clinical trials:

Search ClinicalTrials for Nervous System Cancer

Search NIH Clinical Center for Nervous System Cancer

Search CenterWatch for Nervous System Cancer

Genetic Tests for Nervous System Cancer

Anatomical Context for Nervous System Cancer

Sources:
14FMA
See all sources

FMA organs/tissues related to Nervous System Cancer:

14
The nervous sytem

Animal Models for Nervous System Cancer or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Nervous System Cancer:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.1CASP3, SHH, ENO2
2MP:00053978.0EWSR1, SHH, FLI1, ARSA, CASP3
3MP:00036317.3ENO2, SHH, FLI1, ARSA, GAL, CASP3
4MP:00053847.1ENO2, EWSR1, SHH, FLI1, GAL, CASP3

Publications for Nervous System Cancer

Sources:
51PubMed
See all sources

Articles related to Nervous System Cancer:

(show top 50)    (show all 54)
idTitleAuthorsYear
1
LDL Receptor-Related Protein-1: A Regulator of Inflammation in Atherosclerosis, Cancer, and Injury to the Nervous System. (24128688)
2014
2
The Central Nervous System as a Sanctuary Site in ALK-Positive Non-Small-Cell Lung Cancer. (24389440)
2013
3
Beneath the Blood Brain Barrier: The Challenge of Diagnosis and Management of Central Nervous System Involvement in ALK-Positive Lung Cancer. (24389428)
2013
4
Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients. (23661397)
2013
5
Retrospective analysis of risk factors for central nervous system metastases in operable breast cancer: effects of biologic subtype and Ki67 overexpression on survival. (23235554)
2013
6
Influence of catechol-o-methyltransferase genotype (Val158Met) on endocrine, sympathetic nervous and mucosal immune systems in breast cancer survivors. (21974969)
2012
7
Characteristic of galaninergic components of the enteric nervous system in the cancer invasion of human large intestine. (22226150)
2012
8
Medulloblastoma and Brucellosis - Molecular Evidence of Brucella sp in Association with Central Nervous System Cancer. (21475718)
2011
9
ATP-binding cassette transporters in primary central nervous system lymphoma: decreased expression of MDR1 P-glycoprotein and breast cancer resistance protein in tumor capillary endothelial cells. (21165575)
2011
10
Comparison of time trends in brain and central nervous system cancer mortality (1990-2006) between countries based on the WHO mortality database. (21273379)
2011
11
Influence of 6q22-23 on overall survival in primary central nervous system lymphoma. Analysis of North Central Cancer Treatment Group trials 86 72 52, 93 73 51 and 96 73 51. (21275973)
2011
12
Development of central nervous system metastases in patients with advanced non-small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib. (21030498)
2010
13
Long-term health experience of jet engine manufacturing workers: IV. A comparison of central nervous system cancer ascertainment using mortality and incidence data. (20816315)
2010
14
Pain in children with central nervous system cancer: a review of the literature. (20591796)
2010
15
Characteristics and outcomes of elderly patients with primary central nervous system lymphoma: the Memorial Sloan-Kettering Cancer Center experience. (20572045)
2010
16
School-aged children after the end of successful treatment of non-central nervous system cancer: longitudinal assessment of health-related quality of life, anxiety and coping. (19594611)
2009
17
Differential N-glycosylation of kallikrein 6 derived from ovarian cancer cells or the central nervous system. (19088065)
2009
18
Human epidermal growth factor receptor 2-positive breast cancer and central nervous system metastases. (19770385)
2009
19
An unexpected synergist role of P-glycoprotein and breast cancer resistance protein on the central nervous system penetration of the tyrosine kinase inhibitor lapatinib (N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016). (19056914)
2009
20
Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells. (19920894)
2009
21
Comparison of time trends in brain central nervous system cancer incidence (1973-97) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vols IV-VIII. (18772173)
2008
22
Molecular predictors of human nervous system cancer responsiveness to enediyne chemotherapy. (18338171)
2008
23
Neuropsychological sequelae of non-central nervous system cancer and cancer therapy. (18415683)
2008
24
Risk factors for central nervous system metastasis in patients with metastatic breast cancer. (17848738)
2007
25
Primary breast cancer phenotypes associated with propensity for central nervous system metastases. (16826579)
2006
26
Whole-brain radiotherapy and high-dose methylprednisolone for elderly patients with primary central nervous system lymphoma: Results of North Central Cancer Treatment Group (NCCTG) 96-73-51. (16863926)
2006
27
Primary central nervous system lymphoma: the Memorial Sloan-Kettering Cancer Center prognostic model. (17116938)
2006
28
The treatment of primary central nervous system lymphoma in 122 immunocompetent patients: a population-based study of successively treated cohorts from the British Colombia Cancer Agency. (15651059)
2005
29
Central nervous system metastases in breast cancer patients administered trastuzumab. (15979804)
2005
30
Epidermal growth factor receptor status in breast cancer metastases to the central nervous system. Comparison with HER-2/neu status. (15335267)
2004
31
Cytotoxicity and oncostatic activity of the thiazolidinedione derivative CGP 52608 on central nervous system cancer cells. (15194216)
2004
32
Central nervous system listeriosis confused with leptomeningeal carcinomatosis in cancer patients. (15057164)
2004
33
Pyridoxal phosphatase is a novel cancer autoantigen in the central nervous system. (15452547)
2004
34
Occult central nervous system involvement in patients with metastatic breast cancer: prevalence, predictive factors and impact on overall survival. (12853349)
2003
35
Her-2/neu status in breast cancer metastases to the central nervous system. (14567724)
2003
36
High-dose methotrexate-based chemotherapy followed by consolidating radiotherapy in non-AIDS-related primary central nervous system lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962. (14597741)
2003
37
German Cancer Society Neuro-Oncology Working Group NOA-03 multicenter trial of single-agent high-dose methotrexate for primary central nervous system lymphoma. (11835382)
2002
38
Immunogenetic characteristics of patients with stomach cancer and predominant activity of either sympathetic or parasympathetic autonomic nervous system. (11013848)
2000
39
Nervous system cancer mortality in an industrialized area of Brazil 1980-1993. (10920400)
2000
40
Exploitation of immune mechanisms in the treatment of central nervous system cancer. (10914414)
2000
41
HIP/PAP gene, encoding a C-type lectin overexpressed in primary liver cancer, is expressed in nervous system as well as in intestine and pancreas of the postimplantation mouse embryo. (10329612)
1999
42
Endocrine mechanism of action of toremifene at the level of the central nervous system in advanced breast cancer patients. (9685060)
1998
43
Detection of membrane-associated human chorionic gonadotropin and its subunits on human cultured cancer cells of the nervous system. (9232319)
1997
44
Risk of nervous system cancer among workers exposed to lead. (8673517)
1996
45
Intermediate filaments in the nervous system: implications in cancer. (9034605)
1996
46
Human malignant astrocytoma xenografts migrate in rat brain: a model for central nervous system cancer research. (2651679)
1989
47
Human retrovirus family: cancer, central nervous system disease, and AIDS. (2842514)
1988
48
Asbestosis, the nervous system and cancer. (6497337)
1984
49
Brain and central nervous system cancer mortality in U. S. rubber workers. (6953785)
1982
50
The increasing incidence of central nervous system leukemia in children. (Children's Cancer Study Group A). (5271211)
1970

Genetic Variations for Nervous System Cancer

Expression for genes affiliated with Nervous System Cancer

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Nervous System Cancer

Search GEO for disease gene expression data for Nervous System Cancer.

Pathways for genes affiliated with Nervous System Cancer

Compounds for genes affiliated with Nervous System Cancer

Sources:
45Novoseek, 60Tocris Bioscience, 24HMDB, 29IUPHAR, 11DrugBank, 50PharmGKB
See all sources

Compounds related to Nervous System Cancer according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1askin459.8EWSR1, ENO2
2taurine45 60 2411.6ENO2, GAL
3octreotide45 60 29 1112.5GAL, ENO2
4serine459.4GAL, EWSR1, ARSA
5etoposide45 50 60 1112.1CASP3, GAL, ENO2
6phosphatidylserine45 29 1111.1CD99, GAL, CASP3
7glutamine458.9EWSR1, ARSA, ENO2
8paraffin458.8CD99, EWSR1, ENO2
9oligonucleotide458.6EWSR1, GAL, ARSA, FLI1
10retinoic acid45 249.6GAL, ENO2, EWSR1, CASP3

GO Terms for genes affiliated with Nervous System Cancer

Sources:
16Gene Ontology
See all sources

Cellular components related to Nervous System Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058867.7ENO2, CD99, SHH, ARSA, EWSR1, CASP3

Molecular functions related to Nervous System Cancer according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptidase activityGO:0082339.6SHH, CASP3

Products for genes affiliated with Nervous System Cancer

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nervous System Cancer

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet