Nervous System Cancer malady

Disease Ontology: An organ system cancer located in the nervous sytem that affects the central or peripheral nervous system.⁶

MalaCards: Nervous System Cancer, also known as neuroepithelial, perineurial, and schwann cell neoplasm, is related to nasopharynx carcinoma and central nervous system cancer. An important gene associated with Nervous System Cancer is ARSA (arylsulfatase A). The drugs prednisone and prednisolone tebutate and the compound serine have been mentioned in the context of this disorder. Affiliated tissues include the nervous sytem, and related mouse phenotypes are hearing/vestibular/ear and immune system.

Wikipedia: A nervous system neoplasm is a tumor affecting the nervous system. Types include:⁴⁴ more...

Aliases & Descriptions:

nervous system cancer 6 neuroepithelial, perineurial, and schwann cell neoplasm 43 neoplasm of nervous system (disorder) 6 malignant neoplasm of nervous system 6 tumor of the nervous system 6 nervous system neoplasms 43

nervous system neoplasm 6 nervous system tumor 32 malignant neoplasms 43 neural neoplasm 6 neural tumor 6 neoplasms 43

Diseases related to nervous system cancer by text searches and GeneDecks gene sharing:

(show top 50)    (show all 917)

id	Related Disease	Score	Top Affiliating Genes
1	nasopharynx carcinoma	29.9	CD99, CASP3
2	central nervous system cancer	29.2	CD99, FLI1, ARSA, EWSR1, SHH
3	neuroendocrine tumor	27.3	SHH, CASP3, CD99
4	anaplastic large cell lymphoma	27.0	CD99, CASP3, SHH
5	embryonal cancer	26.9	FLI1, CD99
6	sarcoma	26.9	EWSR1, CASP3, FLI1, CD99
7	neuroectodermal tumors	26.5	CD99, FLI1, CASP3, EWSR1
8	rhabdomyosarcoma	25.9	EWSR1, FLI1, CD99
9	wilms tumor	25.9	EWSR1, CASP3, FLI1
10	b-cell lymphomas	25.7	SHH, CASP3, FLI1, CD99
11	breast cancer	25.7	SHH, EWSR1, CASP3, ARSA, FLI1, CD99
12	malignant glioma	25.7	SHH, EWSR1, CASP3, FLI1, CD99
13	melanoma	25.5	SHH, EWSR1, CASP3, FLI1, CD99
14	lymphoblastic leukemia	25.2	CD99, FLI1, CASP3, SHH
15	neuroblastoma	25.1	SHH, EWSR1, CASP3, CD99
16	leukemia	25.1	CD99, FLI1, CASP3, EWSR1, SHH
17	liposarcoma	24.5	FLI1, CASP3, EWSR1
18	bladder sarcoma	24.2	FLI1, CD99
19	acute lymphoblastic leukemia	23.9	SHH, CASP3, FLI1, CD99
20	synovial sarcoma	23.9	CD99, FLI1, CASP3, EWSR1
21	prostate carcinoma	23.5	SHH, EWSR1, CASP3, FLI1, CD99
22	peripheral primitive neuroectodermal tumor	23.3	EWSR1, FLI1, CD99
23	krabbe disease	12.9	ARSA, CASP3
24	chondrodysplasia punctata	12.8	CD99, ARSA
25	extraosseous ewing's sarcoma	12.8	CD99, EWSR1
26	moyamoya disease	12.6	CASP3, SHH
27	germ cell cancer	12.6	EWSR1, SHH
28	esthesioneuroblastoma	12.5	FLI1, CD99
29	lymphoblastic lymphoma	12.5	CD99, FLI1
30	chondrodysplasia	12.3	CD99, ARSA
31	desmoplastic small round cell tumor	12.0	EWSR1, FLI1, CD99
32	ataxia	11.6	CD99, ARSA, CASP3, EWSR1
33	neuroepithelioma	11.5	EWSR1, CASP3, FLI1, CD99
34	cerebral primitive neuroectodermal tumor	11.5	EWSR1, CASP3, FLI1, CD99
35	thyroiditis	9.5
36	carcinoma	9.2
37	pancreatitis	9.0
38	pediatric central nervous system tumor	8.7
39	autonomic nervous system neoplasm	8.2
40	tongue cancer	7.9
41	liver cancer	7.8
42	adenocarcinoma	7.7
43	lip cancer	7.6
44	colonic neoplasm	7.5
45	lung neoplasm	7.4
46	cervicitis	7.3
47	brain cancer	7.2
48	esophageal cancer	7.1
49	intraepithelial neoplasm	7.1
50	stomach cancer	7.1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 dexamethasone, dexamethasone acetate, dexamethasone acetate pwdr [va product], dexamethasone phosphate, dexamethasone sodium phosphate, dexamethasone sodium phosphate pwdr [va product], linolenic acid, methylprednisolone, methylprednisolone acetate, methylprednisolone sodium succinate, prednisolone, prednisolone acetate, prednisolone acetate pwdr [va product], prednisolone pwdr [va product], prednisolone sodium phosphate, prednisolone tebutate, prednisone, prednisone pwdr [va product]

FMA organs/tissues related to nervous system cancer:

¹¹

MGI Mouse Phenotypes related to nervous system cancer:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hearing/vestibular/ear phenotype	MP:0005377	9.0	ARSA, CASP3, SHH
2	immune system phenotype	MP:0005387	7.3	FLI1, ARSA, CASP3, EWSR1, SHH

Articles related to nervous system cancer:

id	Title	Authors	Year	Affiliating Genes
1	Molecular predictors of human nervous system cancer responsiveness to enediyne chemotherapy. (18338171)	Rogers D.... Schor N.F.	2008	CASP3

Genes related to nervous system cancer according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	ARSA	arylsulfatase A	11.0
2	CD99	CD99 molecule	11.0
3	SHH	sonic hedgehog	11.0
4	EWSR1	Ewing sarcoma breakpoint region 1	11.0
5	FLI1	Friend leukemia virus integration 1	11.0
6	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications

Compounds related to nervous system cancer according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	serine32	8.1	FLI1, ARSA, CASP3, EWSR1

Molecular functions related to nervous system cancer according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	peptidase activity	GO:008233	9.4	CASP3, SHH