MCID: NRV006
MIFTS: 39

Nervous System Cancer malady

Neuronal diseases, Cancer diseases categories

Summaries for Nervous System Cancer

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 An organ system cancer located in the nervous sytem that affects the central or peripheral nervous system.

MalaCards: Nervous System Cancer, also known as neuroepithelial, perineurial, and schwann cell neoplasm, is related to central nervous system cancer and malignant glioma. An important gene associated with Nervous System Cancer is ARSA (arylsulfatase A). The compounds ganglioside and glutamine have been mentioned in the context of this disorder. Affiliated tissues include the nervous sytem and brain, and related mouse phenotypes are taste/olfaction and hearing/vestibular/ear.

Wikipedia:66 A nervous system neoplasm is a tumor affecting the nervous system. Types include: more...

Aliases & Classifications for Nervous System Cancer

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Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

nervous system cancer 9
neuroepithelial, perineurial, and schwann cell neoplasm 63
malignant neoplasm of nervous system 9
tumor of the nervous system 9
neoplasm of nervous system 9
nervous system neoplasms 63
nervous system neoplasm 9
nervous system tumor 46
neural neoplasm 9
neural tumor 9


External Ids:

Disease Ontology9 DOID:3093
SNOMED-CT59 188306000
MeSH36 D009380

Related Diseases for Nervous System Cancer

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Central Nervous System Cancer family:

nervous system cancer

Diseases related to Nervous System Cancer via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1central nervous system cancer30.9ARSA, ENO2
2malignant glioma30.0CASP3, ENO2
3medulloblastoma30.0ENO2, CASP3
4endotheliitis10.3
5autonomic nervous system neoplasm10.3
6leukemia10.2
7neuronitis10.1
8childhood leukemia10.1
9ectomesenchymoma10.1
10central neurocytoma10.1
11olfactory neural tumor10.1
12neuroblastoma10.1
13neuroma10.1
14krabbe disease10.1ARSA
15central nervous system hematologic cancer10.0
16encephalomyelitis10.0
17spinal cancer10.0
18glioma somatic10.0
19neuroepithelioma10.0ENO2, CASP3
20prion disease10.0CASP3, ENO2
21neurofibromatosis10.0
22ganglioglioma10.0
23tuberous sclerosis10.0
24hyperprolactinemia10.0
25pleomorphic xanthoastrocytoma10.0
26melanoma10.0
27meningitis10.0
28oligodendroglioma10.0
29perineurioma10.0
30mowat-wilson syndrome10.0
31aids dementia complex10.0
32pilocytic astrocytoma10.0
33turcot syndrome10.0
34lung benign neoplasm10.0CASP3, ENO2
35vascular disease10.0ENO2, CASP3
36pheochromocytoma10.0ENO2, CASP3
37brain cancer10.0ENO2, CASP3
38lung small cell carcinoma10.0CASP3, ENO2
39astrocytoma10.0
40brucellosis10.0
41meningioma10.0
42peripheral nervous system neoplasm10.0
43lung cancer10.0CASP3, ENO2
44prostate cancer10.0ENO2, CASP3
45burkitt's lymphoma10.0ENO2, CASP3
46retinoblastoma10.0ENO2, CASP3
47ganglioneuroma9.9
48paraganglioma9.9
49fibrosarcoma9.9
50ganglioneuroblastoma9.9

Graphical network of the top 20 diseases related to Nervous System Cancer:



Diseases related to nervous system cancer

Symptoms for Nervous System Cancer

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Drugs & Therapeutics for Nervous System Cancer

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Nervous System Cancer

Drug clinical trials:

Search ClinicalTrials for Nervous System Cancer

Search NIH Clinical Center for Nervous System Cancer

Search CenterWatch for Nervous System Cancer

Genetic Tests for Nervous System Cancer

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Anatomical Context for Nervous System Cancer

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Nervous System Cancer:

34
Brain

FMA organs/tissues related to Nervous System Cancer:

15
The nervous sytem

Animal Models for Nervous System Cancer or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Nervous System Cancer:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.1ENO2, CASP3
2MP:00053779.0ARSA, CASP3
3MP:00053868.4ARSA, ENO2, CASP3
4MP:00036318.2CASP3, ENO2, ARSA

Publications for Nervous System Cancer

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Sources:
53PubMed
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Articles related to Nervous System Cancer:

(show all 16)
idTitleAuthorsYear
1
Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients. (23661397)
2013
2
Medulloblastoma and Brucellosis - Molecular Evidence of Brucella sp in Association with Central Nervous System Cancer. (21475718)
2011
3
Comparison of time trends in brain and central nervous system cancer mortality (1990-2006) between countries based on the WHO mortality database. (21273379)
2011
4
Long-term health experience of jet engine manufacturing workers: IV. A comparison of central nervous system cancer ascertainment using mortality and incidence data. (20816315)
2010
5
Pain in children with central nervous system cancer: a review of the literature. (20591796)
2010
6
School-aged children after the end of successful treatment of non-central nervous system cancer: longitudinal assessment of health-related quality of life, anxiety and coping. (19594611)
2009
7
Induction of cytotoxicity, apoptosis and cell cycle arrest by 1-t-butyl carbamoyl, 7-methyl-indole-3-ethyl isothiocyanate (NB7M) in nervous system cancer cells. (19920894)
2009
8
Comparison of time trends in brain central nervous system cancer incidence (1973-97) in East Asia, Europe and USA, from Cancer Incidence in Five Continents Vols IV-VIII. (18772173)
2008
9
Molecular predictors of human nervous system cancer responsiveness to enediyne chemotherapy. (18338171)
2008
10
Neuropsychological sequelae of non-central nervous system cancer and cancer therapy. (18415683)
2008
11
Cytotoxicity and oncostatic activity of the thiazolidinedione derivative CGP 52608 on central nervous system cancer cells. (15194216)
2004
12
Nervous system cancer mortality in an industrialized area of Brazil 1980-1993. (10920400)
2000
13
Exploitation of immune mechanisms in the treatment of central nervous system cancer. (10914414)
2000
14
Risk of nervous system cancer among workers exposed to lead. (8673517)
1996
15
Human malignant astrocytoma xenografts migrate in rat brain: a model for central nervous system cancer research. (2651679)
1989
16
Brain and central nervous system cancer mortality in U. S. rubber workers. (6953785)
1982

Variations for Nervous System Cancer

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Expression for genes affiliated with Nervous System Cancer

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nervous System Cancer

Search GEO for disease gene expression data for Nervous System Cancer.

Pathways for genes affiliated with Nervous System Cancer

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Compounds for genes affiliated with Nervous System Cancer

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Sources:
46Novoseek, 52PharmGKB, 62Tocris Bioscience, 12DrugBank, 25HMDB
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Compounds related to Nervous System Cancer according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1ganglioside469.6ARSA, ENO2
2glutamine469.5ENO2, ARSA
3docetaxel46 52 62 1212.4ENO2, CASP3
4creatinine469.3ENO2, ARSA
5etoposide46 52 62 1212.3ENO2, CASP3
6magnesium46 25 1211.3ARSA, ENO2
7pd 98,059469.3ENO2, CASP3
8ceramide469.3CASP3, ARSA
9superoxide46 2510.2ENO2, CASP3
10leucine469.2ARSA, ENO2
11cisplatin46 52 62 1212.2ENO2, CASP3
12aspartate469.0ARSA, ENO2
13lactate468.8ARSA, ENO2, CASP3

GO Terms for genes affiliated with Nervous System Cancer

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Products for genes affiliated with Nervous System Cancer

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nervous System Cancer

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet