MCID: NRV007
MIFTS: 61

Nervous System Disease malady

Neuronal diseases category

Summaries for Nervous System Disease

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A disease of anatomical entity that is located in the central nervous system or located in the peripheral nervous system.

MalaCards: Nervous System Disease, also known as nervous system disorder, is related to systemic lupus erythematosus and leukemia. An important gene associated with Nervous System Disease is CHRM1 (cholinergic receptor, muscarinic 1), and among its related pathways are GPCRs, Other and Calcium signaling pathway. The compounds (-)aceclidine and vu0255035 have been mentioned in the context of this disorder. Affiliated tissues include the central nervous system or, t cells and brain, and related mouse phenotypes are muscle and behavior/neurological.

Wikipedia:63 Nervous system disease refers to a general class of medical conditions affecting the nervous system. more...

Aliases & Classifications for Nervous System Disease

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 25ICD10
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Related Diseases for Nervous System Disease

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17GeneCards, 18GeneDecks
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Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Autoimmune Disease of the Nervous System
Central Nervous System Disease Congenital Nervous System Abnormality

Diseases related to Nervous System Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 337)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.7APOH, CD46, CXCR3, IL18
2leukemia30.5PLAUR, CXCR3, CD46, PROM1
3brain disease30.4TSPO, POLG, GC
4multiple sclerosis30.4GC, MOG, CD46, CXCR3, IL18, TSPO
5neuropathy30.3DAG1, POLG, SACS
6hepatitis30.1IL18
7myasthenia gravis29.8MOG
8myocardial infarction29.8PROM1
9viral infectious disease29.8CHRM2, CD46, CXCR3, IL18, PLAUR
10central nervous system disease11.1
11lupus erythematosus10.5
12peripheral nervous system disease10.5
13central nervous system leukemia10.4
14acute leukemia10.3
15lymphocytic choriomeningitis10.3
16measles10.3
17encephalomyelitis10.3
18central nervous system lymphoma10.3
19histiocytosis10.3
20langerhans-cell histiocytosis10.3
21pneumonia10.3
22myopathy due to calsequestrin and serca1 protein overload10.3
23autoimmune disease of central nervous system10.2
24autonomic nervous system disease10.2
25lymphoblastic leukemia10.2
26stomatitis10.2
27myotonia congenita, atypical, acetazolamide-responsive10.2
28cerebritis10.2
29acute myeloid leukemia10.2
30central core myopathy10.2
31kaposi's sarcoma10.2
32arthritis10.2
33autoimmune disease of the nervous system10.2
34central nervous system sarcoma10.2
35herpes simplex10.2
36myeloid leukemia10.2
37sarcoma10.2
38muscular dystrophy, rigid spine, 110.2
39emery-dreifuss muscular dystrophy 2, ad10.2
40pelizaeus-merzbacher disease10.1
41riley-day syndrome10.1
42horner's syndrome10.1
43myotonic dystrophy10.1
44pure autonomic failure10.1
45subacute sclerosing panencephalitis10.1
46lambert-eaton myasthenic syndrome10.1
47psoriatic arthritis10.1
48metachromatic leukodystrophy10.1
49neuronitis10.1
50acquired immunodeficiency syndrome10.1

Graphical network of the top 20 diseases related to Nervous System Disease:



Diseases related to nervous system disease

Clinical Features for Nervous System Disease

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Drugs & Therapeutics for Nervous System Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Nervous System Disease

Drug clinical trials:

Search ClinicalTrials for Nervous System Disease

Search NIH Clinical Center for Nervous System Disease

Search CenterWatch for Nervous System Disease

Genetic Tests for Nervous System Disease

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Anatomical Context for Nervous System Disease

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Nervous System Disease:

32
T cells, Brain, Testes, B cells, Bone, Pituitary, Myeloid, Bone marrow, Colon, Heart, Kidney, Skin, Monocytes, Spinal cord, Liver, Retina, Adrenal gland

FMA organs/tissues related to Nervous System Disease:

14
The central nervous system or

Animal Models for Nervous System Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Nervous System Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053699.5CHRM5, MOG, PLAUR, IL18, DAG1, POLG
2MP:00053869.3PLAUR, DAG1, IL18, CHRM3, CHRM1, CHRM2
3MP:00053859.3CHRM2, CHRM4, POLG, CHRM5, CHRM3, CXCR3
4MP:00053769.0CXCR3, IL18, CHRM5, CHRM3, CHRM1, CHRM2
5MP:00036318.9CHRM2, PROM1, DAG1, IL18, POLG, CHRM3

Publications for Nervous System Disease

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50PubMed
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Articles related to Nervous System Disease:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
Childhood primary angiitis of the central nervous system: identifying disease trajectories and early risk factors for persistently higher disease activity. (22544528)
2012
2
Lyme disease: a multisystem infection that affects the nervous system. (23221844)
2012
3
Distribution of enteroviruses in hospitalized children with hand, foot and mouth disease and relationship between pathogens and nervous system complications. (22230340)
2012
4
High dose methotrexate and extended hours high-flux hemodialysis for the treatment of primary central nervous system lymphoma in a patient with end stage renal disease. (22432089)
2012
5
Curative treatment for central nervous system medulloepithelioma despite residual disease after resection. Report of two cases treated according to the GPHO Protocol HIT 2000 and review of the literature. (22037651)
2011
6
Cerebrovascular disease in central nervous system infections. (21964846)
2011
7
Chronic wasting disease prion trafficking via the autonomic nervous system. (21777560)
2011
8
Autoantibodies in inflammatory demyelinating diseases of the central nervous system. (18951202)
2008
9
Central nervous system Toll-like receptor expression in response to Theiler's murine encephalomyelitis virus-induced demyelination disease in resistant and susceptible mouse strains. (19094215)
2008
10
Hand, foot and mouth disease complicated with central nervous system involvement in Taiwan in 1980-1981. (17339164)
2007
11
NDRG1-linked Charcot-Marie-Tooth disease (CMT4D) with central nervous system involvement. (17142040)
2007
12
Electricity in the treatment of nervous system disease. (17691352)
2007
13
NF-kappaB functions in the nervous system: from development to disease. (16997282)
2006
14
Prevalence of Bartonella henselae antibodies in serum of cats with and without clinical signs of central nervous system disease. (16949848)
2006
15
A case of rapidly progressive Rosai-Dorfman disease restricted to the central nervous system. (16116557)
2005
16
No gender differences in the progression of nervous system disease in HIV infection. (15213565)
2004
17
Granulomatous angiitis of the central nervous system revealing Hodgkin's disease. (15164198)
2004
18
Childhood autoimmune neurologic diseases of the central nervous system. (14743647)
2003
19
Complete proteinogram of cerebrospinal fluid and its contribution to the diagnostics of inflammatory and autoimmune diseases of the central nervous system. (14577135)
2003
20
A novel simian immunodeficiency virus model that provides insight into mechanisms of human immunodeficiency virus central nervous system disease. (12491150)
2002
21
Primary angiitis of the central nervous system and Alzheimer's disease: clinically and pathologically evident in a single patient. (11128690)
2000
22
The role of depression severity in the cognitive functioning of elderly subjects with central nervous system disease. (10863886)
2000
23
Central nervous system involvement of Epstein-Barr virus lymphoproliferative disease in a patient with acute lymphocytic leukemia. (10779033)
2000
24
Distribution and retrograde transport of trophic factors in the central nervous system: functional implications for the treatment of neurodegenerative diseases. (10080385)
1999
25
Tumor necrosis factor alpha is a determinant of pathogenesis and disease progression in mycobacterial infection in the central nervous system. (10318940)
1999
26
Chemokines/chemokine receptors in the central nervous system and Alzheimer's disease. (10190688)
1999
27
Measles virus infection in a transgenic model: virus-induced immunosuppression and central nervous system disease. (10490102)
1999
28
Bone marrow transplantation as effective treatment of central nervous system disease in globoid cell leukodystrophy, metachromatic leukodystrophy, adrenoleukodystrophy, mannosidosis, fucosidosis, aspartylglucosaminuria, Hurler, Maroteaux-Lamy, and Sly syndromes, and Gaucher disease type III. (10226749)
1999
29
Humoral immunity in the central nervous system of Lewis rats infected with Borna disease virus. (9817440)
1998
30
Haemangioblastoma of the central nervous system in von Hippel-Lindau disease. French VHL Study Group. (9681857)
1998
31
Animal models for nervous system disease in systemic lupus erythematosus. (9292036)
1997
32
Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: relevance to diseases of the nervous system. (8962095)
1996
33
Association of antiphospholipid antibodies with central nervous system disease in systemic lupus erythematosus. (7573096)
1995
34
The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system. (7857654)
1995
35
Central nervous system disease in SjAPgren's syndrome. (7653943)
1995
36
Bone marrow transplantation corrects the enzyme defect in neurons of the central nervous system in a lysosomal storage disease. (8159689)
1994
37
Electrocardiographic changes in central nervous system disease. (8316185)
1993
38
Interleukin-8 is produced in neoplastic and infectious diseases of the human central nervous system. (1643627)
1992
39
Anaesthesia and central nervous system disease in small animals. Part II: Anaesthetic management for specific diseases and procedures. (2204465)
1990
40
Precise relaxation time measurements of normal-appearing white matter in inflammatory central nervous system disease. (2779420)
1989
41
Whipple disease of the nervous system. (6178057)
1982
42
Blunted TSH response to TRH in patients with central nervous system disease. (6787920)
1981
43
Central nervous system disease. (509758)
1979
44
An ultrastructural study of central nervous system disease produced by wild-type and temperature-sensitive mutants of vesicular stomatitis virus. (183052)
1976
45
Bromide partition test in the evaluation of the blood-cerebrospinal barrier in children with congenital hypothyroidism and central nervous system disease. (1224969)
1975
46
Three familial midline malformtion syndromes of the central nervous system: agenesis of the corpus callosum and anterior horn-cell disease; agenesis of cerebellar vermis; and atrophy of the cerebellar vermis. (1227532)
1975
47
Viral central nervous system disease. An etiologic study conducted at the Los Angeles County General Hospital. (14464000)
1962
48
An unusual form of central nervous system disease in a newborn infant. (13097296)
1953
49
CLINICO-PATHOLOGIC conference: progressive central nervous system disease. (13057884)
1953
50
Curative treatment of lathyrism, a disease of the nervous system. (20998303)
1946

Genetic Variations for Nervous System Disease

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Expression for genes affiliated with Nervous System Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nervous System Disease

Search GEO for disease gene expression data for Nervous System Disease.

Pathways for genes affiliated with Nervous System Disease

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome
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Compounds for genes affiliated with Nervous System Disease

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28IUPHAR, 59Tocris Bioscience, 11DrugBank, 44Novoseek, 2BitterDB, 49PharmGKB, 24HMDB
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Compounds related to Nervous System Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1(-)aceclidine2810.4CHRM1, CHRM3, CHRM5, CHRM4, CHRM2
2vu02550352810.4CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
3af-dx 11628 5911.4CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
4mt32810.4CHRM3, CHRM1, CHRM2, CHRM5, CHRM4
5(+)aceclidine2810.4CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
6p-f-hhsid2810.3CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
7hhsid2810.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
8nnc 11-13142810.3CHRM3, CHRM1, CHRM5, CHRM4, CHRM2
9afdx3842810.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
10Metixene1110.3CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
11Cryptenamine1110.3CHRM1, CHRM3, CHRM2, CHRM4, CHRM5
12Homatropine Methylbromide1110.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
13brucine n-oxide2810.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
14Trihexyphenidyl1110.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
15n-benzyl brucine2810.3CHRM3, CHRM1, CHRM2, CHRM4, CHRM5
16mt72810.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
17n-chloromethyl-brucine2810.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
18nnc 11-16072810.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
19ipratropium2810.3CHRM3, CHRM1, CHRM2, CHRM5, CHRM4
20[3h]n-methyl scopolamine2810.3CHRM5, CHRM1, CHRM4, CHRM2, CHRM3
214-damp59 2811.3CHRM2, CHRM3, CHRM1, CHRM4, CHRM5
22[3h]qnb2810.3CHRM1, CHRM2, CHRM5, CHRM3, CHRM4
23nnc 11-15852810.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
24Aclidinium1110.3CHRM1, CHRM5, CHRM4, CHRM2, CHRM3
25Solifenacin1110.3CHRM5, CHRM1, CHRM4, CHRM2, CHRM3
26Benzquinamide1110.3CHRM3, CHRM4, CHRM1, CHRM2, CHRM5
27himbacine28 4411.3CHRM1, CHRM5, CHRM4, CHRM2, CHRM3
28darifenacin44 28 1112.3CHRM5, CHRM3, CHRM1, CHRM2, CHRM4
29methoctramine44 2811.3CHRM1, CHRM3, CHRM5, CHRM4, CHRM2
30brucine2 28 4412.2CHRM5, CHRM2, CHRM4, CHRM1, CHRM3
31tropicamide44 59 1112.2CHRM4, CHRM2, CHRM1, CHRM3
32Fesoterodine1110.2CHRM4, CHRM1, CHRM2, CHRM3, CHRM5
33tolterodine44 49 28 1113.2CHRM5, CHRM3, CHRM4, CHRM2, CHRM1
34Chlorprothixene1110.2CHRM5, CHRM2, CHRM1, CHRM3, CHRM4
35brompheniramine44 11 2412.2CHRM4, CHRM2, CHRM5, CHRM3, CHRM1
36milameline2810.2CHRM5, CHRM4, CHRM3, CHRM1
37Propiomazine1110.2CHRM2, CHRM1, CHRM3, CHRM5, CHRM4
38promethazine44 1111.2CHRM2, CHRM3, CHRM5, CHRM1, CHRM4
39strychnine44 2 2812.2CHRM5, CHRM1, CHRM2, CHRM3, CHRM4
40scopolamine44 28 11 2413.2TSPO, CHRM1, CHRM2, CHRM5, CHRM4, CHRM3
41maprotiline44 1111.1CHRM3, CHRM5, CHRM2, CHRM4, CHRM1
42mcn-a-3432810.1CHRM4, CHRM5, CHRM1, CHRM3
43xanomeline28 4411.1CHRM1, CHRM3, CHRM4, CHRM2, CHRM5
44win 51,7082810.1CHRM1, CHRM2, CHRM4, CHRM3
45hexahydrodifenidol2810.1CHRM5, CHRM4, CHRM2, CHRM3
46vincamine2810.1CHRM4, CHRM2, CHRM1, CHRM3
47eburnamonine2810.1CHRM4, CHRM2, CHRM1, CHRM3
48gö 78742810.0CHRM4, CHRM3, CHRM1, CHRM2
49acetylcholine44 49 28 11 2413.8CHRM2, MOG, IL18, CHRM3, CHRM1, TSPO
50oxotremorine-m289.8CHRM4, CHRM2, CHRM1, CHRM3

GO Terms for genes affiliated with Nervous System Disease

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16Gene Ontology
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Cellular components related to Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1asymmetric synapseGO:03227910.3CHRM1, CHRM3
2postsynaptic membraneGO:0452119.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3, DAG1
3cell junctionGO:0300549.6CHRM1, CHRM5, CHRM3, CHRM2, CHRM4
4integral to plasma membraneGO:0058879.4CHRM3, CHRM1, CHRM2, CHRM4, CHRM5, PROM1
5plasma membraneGO:0058869.1DAG1, CXCR3, CD46, CHRM3, CHRM1, PLAUR

Biological processes related to Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayGO:00720710.3CHRM1, CHRM2
2saliva secretionGO:04654110.3CHRM3, CHRM1
3adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayGO:00719710.2CHRM4, CHRM5
4G-protein coupled acetylcholine receptor signaling pathwayGO:00721310.2CHRM1, CHRM4, CHRM5
5regulation of locomotionGO:0400129.9CHRM1, CHRM4
6cell proliferationGO:0082839.8CHRM5, CHRM4, CHRM1, CHRM3, TSPO

Molecular functions related to Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol phospholipase C activityGO:00443510.1CHRM3, CHRM1, CHRM5
2G-protein coupled acetylcholine receptor activityGO:0169079.6CHRM3, CHRM1, CHRM2, CHRM4, CHRM5

Products for genes affiliated with Nervous System Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nervous System Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet