MCID: NRV007
MIFTS: 51

Nervous System Disease malady

Neuronal category

Summaries for Nervous System Disease

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

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Disease Ontology:8 A disease of anatomical entity that is located in the central nervous system or located in the peripheral nervous system.

MalaCards: Nervous System Disease, also known as nervous system disorder, is related to systemic lupus erythematosus and brain disease. An important gene associated with Nervous System Disease is CHRM1 (cholinergic receptor, muscarinic 1), and among its related pathways are GPCRs, Other and Calcium signaling pathway. The compounds (+)aceclidine and vu0255035 have been mentioned in the context of this disorder. Affiliated tissues include the central nervous system or, and related mouse phenotypes are muscle and behavior/neurological.

Wikipedia:64 Nervous system disease refers to a general class of medical conditions affecting the nervous system. more...

Aliases & Classifications for Nervous System Disease

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 25ICD10
See all sources

Related Diseases for Nervous System Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Nervous System Disease family:

autoimmune disease of central nervous system autoimmune disease of the nervous system
central nervous system disease congenital nervous system abnormality

Diseases related to Nervous System Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.8APOH, IL18, CXCR3, CD46
2brain disease30.6TSPO, POLG, GC
3sjogren's syndrome30.0CXCR3, CHRM3, APOH
4viral infectious disease30.0PLAUR, CD46, IL18, CXCR3, CHRM2
5n syndrome10.6
6central nervous system leukemia10.5
7acute leukemia10.4
8lymphocytic choriomeningitis10.4
9measles10.4
10central nervous system lymphoma10.3
11stomatitis10.3
12acute myeloid leukemia10.2
13kaposi's sarcoma10.2
14arthritis10.2
15pelizaeus-merzbacher disease10.2
16subacute sclerosing panencephalitis10.2
17hepatitis c10.2
18psoriatic arthritis10.2
19metachromatic leukodystrophy10.2
20acquired immunodeficiency syndrome10.2
21hepatitis d10.2
22mumps10.2
23autonomic nervous system disease10.2
24urinary system disease10.2
25vasculitis10.2
26hepatitis c virus10.2
27lip disease10.2
28hematopoietic stem cell transplantation10.2
29parkinson's disease10.0
30reflex sympathetic dystrophy10.0
31burning mouth syndrome10.0
32pain disorder10.0
33venezuelan equine encephalitis10.0
34cutaneous anthrax10.0
35riley-day syndrome10.0
36horner's syndrome10.0
37char syndrome10.0
38pure autonomic failure10.0
39charcot-marie-tooth disease with pyramidal features, autosomal dominant10.0
40colpocephaly10.0
41congenital cytomegalovirus10.0
42dysautonomia like disorder10.0
43aids - neurological complications10.0
44autonomic dysfunction10.0
45back pain10.0
46cytomegalovirus infection10.0
47dysautonomia10.0
48hypotonia10.0
49swallowing disorders10.0
50axonal neuropathy10.0

Graphical network of the top 20 diseases related to Nervous System Disease:



Diseases related to nervous system disease

Clinical Features for Nervous System Disease

Drugs & Therapeutics for Nervous System Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Nervous System Disease

Drug clinical trials:

Search ClinicalTrials for Nervous System Disease

Search NIH Clinical Center for Nervous System Disease

Search CenterWatch for Nervous System Disease

Genetic Tests for Nervous System Disease

Anatomical Context for Nervous System Disease

Sources:
14FMA
See all sources

FMA organs/tissues related to Nervous System Disease:

14
The central nervous system or

Animal Models for Nervous System Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Nervous System Disease

Sources:
51PubMed
See all sources

Articles related to Nervous System Disease:

(show top 50)    (show all 610)
idTitleAuthorsYear
1
Expression of neurexin and neuroligin in the enteric nervous system and their down-regulated expression levels in Hirschsprung disease. (23264101)
2013
2
Post-transplant lymphoproliferative disorder: the significance of central nervous system disease. (22717024)
2012
3
MicroRNAs in cerebrospinal fluid as biomarker for disease course monitoring in primary central nervous system lymphoma. (22729947)
2012
4
Novel V97G ASAH1 mutation found in Farber disease patients: unique appearance of the disease with an intermediate severity, and marked early involvement of central and peripheral nervous system. (21893389)
2012
5
Imaging characteristics of Rosai-Dorfman disease in the central nervous system. (21440399)
2012
6
Epilepsy and other central nervous system diseases in atypical autism: a case control study. (21207076)
2011
7
Diagnosis and management of Rosai-Dorfman disease involving the central nervous system. (20350368)
2010
8
Primary central nervous system vasculitis: Is it a single disease? (21031572)
2010
9
Mycoplasma pneumoniae: Innocent Bystander or a True Cause of Central Nervous System Disease? (21308543)
2010
10
High prevalence of autoantibodies against phosphoglycerate mutase 1 in patients with autoimmune central nervous system diseases. (19969379)
2010
11
Detection of myelin autoantibodies: evaluation of an assay system for diagnosis of multiple sclerosis in differentiation from other central nervous system diseases. (19912047)
2009
12
Biomarkers of HIV related central nervous system disease. (18240064)
2008
13
Association of angiitis of central nervous system, cerebral amyloid angiopathy, and Alzheimer's disease: report of an autopsy case. (19337561)
2008
14
Central nervous system signs in X-linked Charcot-Marie-Tooth disease after hyperventilation. (18358413)
2008
15
Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies. (17514199)
2007
16
Peripheral blood gene expression signature mirrors central nervous system disease: the model of multiple sclerosis. (17027885)
2006
17
Proton magnetic resonance spectroscopy and diffusion-weighted imaging of central nervous system whipple disease. (15891498)
2005
18
Central nervous system disease in primary Sjogrens syndrome: the role of magnetic resonance imaging. (15609267)
2004
19
The role of BDNF in epilepsy and other diseases of the mature nervous system. (15250584)
2004
20
The sympathetic nervous system is involved in variant Creutzfeldt-Jakob disease. (12937415)
2003
21
Antigen discovery in chronic human inflammatory central nervous system disease: panning phage-displayed antigen libraries identifies the targets of central nervous system-derived IgG in subacute sclerosing panencephalitis. (11698481)
2001
22
Primary angiitis of the central nervous system as a first presentation in Hodgkin's disease: a case report and review of the literature. (10834654)
2000
23
Kaposi's sarcoma and central nervous system disease: a real association or an artifact of the control group? Terry Beirn Community Programs for Clinical Research on AIDS. (10853981)
2000
24
Central nervous system hemangioblastomas, endolymphatic sac tumors, and von Hippel-Lindau disease. (10809480)
2000
25
Morphological investigation of the enteric nervous system in Hirschsprung's disease and hypoganglionosis using whole-mount colon preparation. (10211651)
1999
26
Cloning the antibody response in humans with inflammatory central nervous system disease: analysis of the expressed IgG repertoire in subacute sclerosing panencephalitis brain reveals disease-relevant antibodies that recognize specific measles virus antigens. (10477623)
1999
27
Radiation therapy for benign central nervous system disease. (10092704)
1999
28
Hirschsprung's disease genes and the development of the enteric nervous system. (9556091)
1998
29
Prognostic significance of coexistent bulky metastatic central nervous system disease in patients with leptomeningeal metastases. (9362983)
1997
30
Gene therapy for nervous system disease. (9616757)
1997
31
1H-magnetic resonance spectroscopy-determined cerebral lactate and poor neurological outcomes in children with central nervous system disease. (9124804)
1997
32
Analysis of cognitive and psychological deficits in systemic lupus erythematosus patients without overt central nervous system disease. (8961909)
1996
33
Detection of human cytomegalovirus mutations associated with ganciclovir resistance in cerebrospinal fluid of AIDS patients with central nervous system disease. (8585743)
1995
34
The effect of Theiler's murine encephalomyelitis virus (TMEV) VP1 carboxyl region on the virus-induced central nervous system disease. (9222346)
1995
35
Autoreactive T and B cells in nervous system diseases. (8382894)
1993
36
Central nervous system disease in childhood ALL. (8217550)
1993
37
Retroviruses and nervous system disease. (1358298)
1992
38
Crohn disease in an infant with central nervous system thrombosis and protein-losing enteropathy. (2202803)
1990
39
Role of the virology laboratory in diagnosis and management of patients with central nervous system disease. (2644021)
1989
40
Central nervous system disease in renal transplant recipients. (3309697)
1987
41
T lymphocyte line-mediated experimental allergic encephalomyelitis--a pharmacologic model for testing of immunosuppressive agents for the treatment of autoimmune central nervous system disease. (3497261)
1987
42
Lymphocytic choriomeningitis virus-induced disease of the central nervous system and the "antigen-sink" hypothesis. (3487710)
1986
43
Neurotransmitters in central nervous system disease. (6126758)
1982
44
Central nervous system tuberculosis: a persistent disease. (5312859)
1971
45
Central nervous system disease in a newborn infant. (5654521)
1968
46
Thrombocytosis, central nervous system disease, and myocardial infarction pattern in infancy. (5922179)
1966
47
WILSON'S DISEASE, AN INBORN ERROR OF METABOLISM AND A MODEL OF DEGENERATIVE CENTRAL NERVOUS SYSTEM DISEASE. (14156393)
1964
48
VIRAL CENTRAL NERVOUS SYSTEM DISEASE. (14043891)
1963
49
Degos' disease (papulosis atrophicans maligna): report of a case with degenerative disease of the central nervous system. (13898142)
1962
50
Psychosomatic aspects of nervous system disease. (13980469)
1962

Genetic Variations for Nervous System Disease

Expression for genes affiliated with Nervous System Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Nervous System Disease

Search GEO for disease gene expression data for Nervous System Disease.

Pathways for genes affiliated with Nervous System Disease

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome
See all sources

Compounds for genes affiliated with Nervous System Disease

Sources:
29IUPHAR, 60Tocris Bioscience, 11DrugBank, 45Novoseek, 2BitterDB, 50PharmGKB, 24HMDB
See all sources

Compounds related to Nervous System Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 147)
idCompoundScoreTop Affiliating Genes
1(+)aceclidine2910.4CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
2vu02550352910.4CHRM2, CHRM1, CHRM3, CHRM4, CHRM5
3af-dx 11629 6011.4CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
4afdx3842910.4CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
5mt32910.4CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
6p-f-hhsid2910.3CHRM3, CHRM1, CHRM2, CHRM5, CHRM4
7hhsid2910.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
8nnc 11-16072910.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
9nnc 11-13142910.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
10Metixene1110.3CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
11Cryptenamine1110.3CHRM1, CHRM3, CHRM2, CHRM4, CHRM5
12Homatropine Methylbromide1110.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
13brucine n-oxide2910.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
14Trihexyphenidyl1110.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
15mt72910.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
16(-)aceclidine2910.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
17n-benzyl brucine2910.3CHRM3, CHRM1, CHRM5, CHRM4, CHRM2
18n-chloromethyl-brucine2910.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
194-damp60 2911.3CHRM5, CHRM3, CHRM1, CHRM2, CHRM4
20ipratropium2910.3CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
21[3h]n-methyl scopolamine2910.3CHRM5, CHRM3, CHRM2, CHRM1, CHRM4
22[3h]qnb2910.3CHRM2, CHRM4, CHRM5, CHRM1, CHRM3
23nnc 11-15852910.3CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
24himbacine29 4511.3CHRM4, CHRM5, CHRM2, CHRM1, CHRM3
25Benzquinamide1110.3CHRM1, CHRM2, CHRM4, CHRM3, CHRM5
26Aclidinium1110.3CHRM2, CHRM1, CHRM3, CHRM4, CHRM5
27arecaidine propargyl ester2910.3CHRM2, CHRM4, CHRM3, CHRM1
28Solifenacin1110.3CHRM5, CHRM1, CHRM4, CHRM2, CHRM3
29brucine2 29 4512.3CHRM4, CHRM2, CHRM1, CHRM3, CHRM5
30methoctramine45 2911.3CHRM5, CHRM2, CHRM3, CHRM4, CHRM1
31darifenacin45 29 1112.2CHRM4, CHRM1, CHRM3, CHRM2, CHRM5
32alcuronium2910.2CHRM4, CHRM2, CHRM1, CHRM3
33Fesoterodine1110.2CHRM2, CHRM3, CHRM5, CHRM4, CHRM1
34tolterodine45 50 29 1113.2CHRM5, CHRM3, CHRM1, CHRM2, CHRM4
35pentylthio-tztp2910.2CHRM4, CHRM2, CHRM1, CHRM3
36Chlorprothixene1110.2CHRM4, CHRM2, CHRM3, CHRM1, CHRM5
37Propiomazine1110.2CHRM1, CHRM3, CHRM2, CHRM4, CHRM5
38brompheniramine45 11 2412.2CHRM4, CHRM3, CHRM2, CHRM5, CHRM1
39promethazine45 1111.2CHRM4, CHRM2, CHRM1, CHRM5, CHRM3
40maprotiline45 1111.2CHRM5, CHRM3, CHRM4, CHRM1, CHRM2
41scopolamine45 29 11 2413.2TSPO, CHRM5, CHRM4, CHRM3, CHRM1, CHRM2
42strychnine45 2 2912.1CHRM5, CHRM4, CHRM2, CHRM1, CHRM3
43xanomeline29 4511.1CHRM3, CHRM4, CHRM5, CHRM2, CHRM1
44hexocyclium2910.1CHRM2, CHRM5, CHRM4, CHRM3
45vincamine2910.1CHRM3, CHRM1, CHRM2, CHRM4
46win 51,7082910.1CHRM3, CHRM1, CHRM2, CHRM4
47mcn-a-3432910.1CHRM5, CHRM4, CHRM1, CHRM3
48tropicamide45 60 1112.0CHRM4, CHRM3, CHRM1, CHRM2
49acetylcholine45 50 29 11 2413.8CHRM1, MOG, CHRM5, CHRM4, CHRM2, DAG1
50Procyclidine119.8CHRM4, CHRM2, CHRM1, CHRM3

GO Terms for genes affiliated with Nervous System Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1asymmetric synapseGO:03227910.3CHRM1, CHRM3
2postsynaptic membraneGO:0452119.9CHRM5, CHRM4, CHRM2, CHRM1, CHRM3, DAG1
3cell junctionGO:0300549.6CHRM1, CHRM5, CHRM3, CHRM2, CHRM4
4integral to plasma membraneGO:0058879.4CHRM3, CHRM1, CHRM2, CHRM4, CHRM5, PROM1
5plasma membraneGO:0058869.1DAG1, CXCR3, CD46, CHRM3, CHRM1, PLAUR

Biological processes related to Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathwayGO:00720710.3CHRM1, CHRM2
2saliva secretionGO:04654110.3CHRM3, CHRM1
3adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathwayGO:00719710.2CHRM4, CHRM5
4G-protein coupled acetylcholine receptor signaling pathwayGO:00721310.2CHRM1, CHRM4, CHRM5
5regulation of locomotionGO:0400129.9CHRM1, CHRM4
6cell proliferationGO:0082839.8CHRM5, CHRM4, CHRM1, CHRM3, TSPO

Molecular functions related to Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phosphatidylinositol phospholipase C activityGO:00443510.1CHRM3, CHRM1, CHRM5
2G-protein coupled acetylcholine receptor activityGO:0169079.6CHRM3, CHRM1, CHRM2, CHRM4, CHRM5

Products for genes affiliated with Nervous System Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nervous System Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet