Nervous System Disease malady

Disease Ontology: A disease of anatomical entity that is located in the central nervous system or located in the peripheral nervous system.⁶

MalaCards: Nervous System Disease, also known as nervous system disorder, is related to central nervous system disease and peripheral nervous system disease. An important gene associated with Nervous System Disease is CHRM5 (cholinergic receptor, muscarinic 5), and among its related pathways are Molecular Mechanisms of Cancer and Immune response_Bacterial infections in normal airways. The compounds pge2 and Homatropine Methylbromide have been mentioned in the context of this disorder. Affiliated tissues include the central nervous system or, bone marrow and brain, and related mouse phenotypes are respiratory system and liver/biliary system.

Wikipedia: Nervous system disease refers to a general class of medical conditions affecting the nervous system.⁴⁴ more...

Aliases & Descriptions:

nervous system disease 6 nervous system disorder 43

Diseases related to nervous system disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 658)

id	Related Disease	Score	Top Affiliating Genes
1	central nervous system disease	33.0	MOG, MBP, CCL2, CCR5, CRYAB, PLP1
2	peripheral nervous system disease	30.0	B2M, APTX, DDC, DAG1, CSF3, POLG
3	pelizaeus-merzbacher disease	29.3	MPZ, MBP, PLP1
4	systemic lupus erythematosus	28.7	CD40LG, CD46, ITGAM, IL18, IL6, APOH
5	multiple sclerosis	28.1	MOG, IL1B, MBP, CCR5, CRYAB
6	meningoencephalitis	27.7	B2M, CD40LG, IL6, MBP, TNF
7	immunodeficiency	27.1	CHRM2, MPZ, MOG, CD40LG, IL18, IL6
8	measles	25.9	CD40LG, CD46, IL1B, IL6, MBP, TNF
9	leukodystrophy	25.8	MPZ, CD40LG, ARSA, MBP, MAG, TNF
10	amyotrophic lateral sclerosis	25.8	B2M, MAG, CCL2, TNF, PPARG, CRYAB
11	neurodegenerative disease	24.0	CHRM1, MPZ, ARSA, IL1B, APTX, MBP
12	lupus erythematosus	23.9	B2M, MOG, CD40LG, CD46, ITGAM, IL18
13	neuropathy	20.1	B2M, MPZ, CD40LG, ARSA, IL1B, IL6
14	neuronitis	16.9	CHRM2, CHRM5, CHRM1, CHRM3, CHRM4, MPZ
15	obstructive lung disease	13.8	CHRM1, CHRM3, CXCR3
16	low compliance bladder	13.8	CHRM2, CHRM1, CHRM3
17	amyloidosis aa	13.6	B2M, IL6
18	mercury poisoning	13.6	B2M, IL18
19	lyme disease	13.6	IL18, GFAP
20	wernicke encephalopathy	13.6	GFAP, TSPO, SLC1A3
21	extrinsic allergic alveolitis	13.5	B2M, CCL2, CXCR3
22	beriberi	13.5	GFAP, TSPO, SLC1A3
23	erdheim-chester disease	13.5	IL1B, CCL2, CCR5
24	collagenous colitis	13.5	CD40LG, APOH, NOS2
25	syphilis	13.5	B2M, CD40LG, APOH, CCR5
26	progressive supranuclear palsy	13.5	CHRM2, CHRM1, CHRM4, APOH, GFAP
27	coronary arteriosclerosis	13.5	IL6, CCL2, CCR5
28	mesangial proliferative glomerulonephritis	13.5	IL6, CCL2, CCR5
29	polyarteritis nodosa	13.5	CD40LG, IL6, APOH
30	euthyroid sick syndrome	13.5	IL1B, IL6
31	proliferative glomerulonephritis	13.4	IL6, CCL2, CCR5, CXCR3
32	nonspecific interstitial pneumonia	13.4	IL18, IL6, CCL2, CXCR3
33	myoepithelioma	13.4	IL6, NOS2, GFAP
34	cerebral hemorrhage	13.4	IL1B, IL6, APOH, GFAP
35	acute liver failure	13.4	GC, TSPO, POLG
36	focal epilepsy	13.3	IL1B, IL6, TSPO
37	west nile virus	13.3	CD40LG, IL1B, IL6, CCR5
38	carpal tunnel syndrome	13.3	B2M, IL1B, IL6, CCL2
39	ovarian hyperstimulation syndrome	13.3	IL18, IL1B, IL6, APOH
40	lymphoproliferative syndrome	13.3	B2M, CD40LG, CCR5, CXCR3
41	iga glomerulonephritis	13.3	CD40LG, IL6, CCL2, CCR5
42	idiopathic pulmonary fibrosis	13.3	IL18, IL1B, CCL2, CXCR3
43	intermediate uveitis	13.3	CCR5, CXCR3
44	central nervous system leukemia	13.3	IL1B, TNF
45	glomerulopathy	13.3	CD40LG, CD46, CCL2, PPARG, CXCR3
46	newborn respiratory distress syndrome	13.3	ITGAM, IL1B, IL6, NOS2
47	viral encephalitis	13.3	MOG, CD40LG, IL1B, IL6, CCL2
48	opportunistic bacterial infectious disease	13.2	B2M, CCR5, TNF
49	schnitzler syndrome	13.2	CD40LG, IL18, TNF
50	peripheral arterial occlusive disease	13.2	CD40LG, IL18, IL1B, IL6, CCL2

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to nervous system disease:

²²

FMA organs/tissues related to nervous system disease:

¹¹

MGI Mouse Phenotypes related to nervous system disease:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	CHRM2, CHRM1, CHRM3
2	liver/biliary system phenotype	MP:0005370	9.9	CCR5, IL6, CHRM4, CHRM3, CHRM2
3	renal/urinary system phenotype	MP:0005367	9.9	DDC, CHRM3, CHRM2
4	endocrine/exocrine gland phenotype	MP:0005379	9.8	CHRM5, CHRM3, CD40LG
5	hematopoietic system phenotype	MP:0005397	8.8	POLG, CSF3, CSF2, ARSA
6	digestive/alimentary phenotype	MP:0005381	8.8	POLG, GFAP, NOS2, CRYAB, CCR5, CCL2
7	integument phenotype	MP:0010771	8.6	POLG, CSF3, CSF2, CHRM2
8	skeleton phenotype	MP:0005390	8.6	POLG, CSF2, NFKB1, CRYAB, PPARG, IL6
9	adipose tissue phenotype	MP:0005375	7.9	POLG, CSF2, NOS2, CRYAB, PPARG, TNF
10	tumorigenesis	MP:0002006	7.9	CSF2, CXCR3, PROM1, NOS2, PPARG, TNF
11	growth/size phenotype	MP:0005378	7.5	PLAUR, PLP1, NFKB1, GFAP, PROM1, CSF2
12	nervous system phenotype	MP:0003631	7.4	CHRM2, PLP1, PROM1, SLC1A3, PLAUR, DDC
13	reproductive system phenotype	MP:0005389	7.3	PLP1, NOS2, CSF2, POLG, TNF, CCR5
14	muscle phenotype	MP:0005369	7.3	DAG1, PPARG, CRYAB, PLAUR, NOS2, NFKB1
15	immune system phenotype	MP:0005387	7.0	PLP1, GFAP, CSF2, PLAUR, CRYAB, MPZ
16	vision/eye phenotype	MP:0005391	6.9	PPARG, CRYAB, PLP1, NOS2, GFAP, PROM1
17	mortality/aging	MP:0010768	6.5	CRYAB, PLP1, NOS2, GFAP, CXCR3, CSF2
18	cardiovascular system phenotype	MP:0005385	6.3	DAG1, PPARG, PLAUR, NOS2, GFAP, PROM1
19	cellular phenotype	MP:0005384	5.4	PPARG, PLAUR, PLP1, NOS2, GFAP, PROM1
20	behavior/neurological phenotype	MP:0005386	4.9	SLC1A3, CHRM2, CHRM5, CHRM1, CHRM3, CHRM4
21	homeostasis/metabolism phenotype	MP:0005376	4.8	SLC1A3, CSF2, GC, CHRM2, CHRM5, CHRM1

Articles related to nervous system disease:

(show all 21)

id	Title	Authors	Year	Affiliating Genes
1	High prevalence of autoantibodies against phosphoglyc erate mutase 1 in patients with autoimmune central nervous system diseases. (19969379)	Kimura A.... Inuzuka T.	2010	PGAM1
2	Biological role of dystroglycan in Schwann cell funct ion and its implications in peripheral nervous system diseases. (20625412)	Masaki T.... Matsumura K.	2010	DAG1
3	Antibodies to native myelin oligodendrocyte glycoprot ein in children with inflammatory demyelinating central nervous system disease. (20033986)	Brilot F.... Hemmer B.	2009	MOG
4	Questioning the role of actinfree Gc-Globulin as actin scavenger in neurodegenerative central nervous system disease: relationship to S-100B levels and blood-brain barrier function. (19000909)	Gressner O.A.... Gressner A.M.	2009	GC
5	The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease. (18096722)	Huttner H.B.... Corbeil D.	2008	PROM1
6	Sequence variation in the CC-chemokine ligand 2 promoter of pigtailed macaques is not associated with the incidence or severity of neuropathology in a simian immunodeficiency virus model of human immunodeficiency virus central nervous system disease. (17162657)	Wright E.K.... Barber S.A.	2006	CCL2
7	PPARgamma as a therapeutic target in central nervous system diseases. (16766086)	Sundararajan S.... Landreth G.	2006	PPARG
8	Expression of the urokinase plasminogen activator and its receptor in HIV-1-associated central nervous system disease. (15579290)	Sidenius N.... Cinque P.	2004	PLAUR
9	Serum and cerebrospinal fluid levels of interleukin-18 in human immunodeficiency virus type 1-associated central nervous system disease. (15765809)	Von Giesen H.J.... Arendt G.	2004	IL18
10	Functional expression of chemokine receptor CCR5 on CD4(+) T cells during virus-induced central nervous system disease. (12477824)	Glass W.G.... Lane T.E.	2003	CCR5
11	Bone marrow stem cell-based gene transfer in a mouse model for metachromatic leukodystrophy: effects on visceral and nervous system disease manifestations. (11850723)	Matzner U.... Gieselmann V.	2002	ARSA
12	A novel simian immunodeficiency virus model that provides insight into mechanisms of human immunodeficiency virus central nervous system disease. (12491150)	Zink M.C.... Clements J.E.	2002	CCL2
13	CXCR3 expression in human central nervous system diseases. (11437993)	Goldberg S.H.... Lavi E.	2001	CXCR3
14	The clinical relevance of antibodies to ribosomal-P common epitope in two targeted systemic lupus erythematosus populations: a large cohort of consecutive patients and patients with active central nervous system disease. (10666163)	Tzioufas A.G.... Moutsopoulos H.M.	2000	APOH
15	Anti-alpha B-crystallin immunoreactivity in inflammatory nervous system diseases. (11200685)	Celet B.... Saruhan-Direskeneli G.	2000	CD40LG, CRYAB
16	Immune response-mediated protection of adult but not neonatal mice from neuron-restricted measles virus infection and central nervous system disease. (9971756)	Lawrence D.M.... Rall G.F.	1999	CD46
17	A close temporal relationship of liver disease to antiribosomal P0 protein antibodies and central nervous system disease in patients with systemic lupus erythematosus. (9558169)	Yoshio T.... Kano S.	1998	CD40LG
18	The M22 antibody identifies highly activated reactive astrocytes responding to central nervous system disease. (8834543)	Eddleston M.... Oldstone M.B.	1996	IL6, GFAP
19	Amyloid and peripheral nervous system disease. (8187375)	Haan J.... Peters W.G.	1994	B2M
20	Autoreactive T and B cells in nervous system diseases. (8382894)	Sun J.B.	1993	MBP, MOG, MAG
21	HIV-1, macrophages, glial cells, and cytokines in AIDS nervous system disease. (2065887)	Merrill J.E.... Chen I.S.	1991	TNF, IL6, CSF2

Genes related to nervous system disease according to GeneCards:

(show all 41)

id	Symbol	Description	Score	GeneCards Section Context
1	CHRM5	cholinergic receptor, muscarinic 5	11.1	Summaries
2	CHRM4	cholinergic receptor, muscarinic 4	11.1	Summaries
3	CHRM1	cholinergic receptor, muscarinic 1	11.1	Summaries
4	CHRM2	cholinergic receptor, muscarinic 2	11.1	Summaries
5	CHRM3	cholinergic receptor, muscarinic 3	11.1	Summaries
6	PGAM1	phosphoglycerate mutase 1 (brain)	11.0	Publications
7	MOG	myelin oligodendrocyte glycoprotein	11.0	Publications
8	GC	group-specific component (vitamin D binding protein)	11.0	Publications
9	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
10	SLC1A3	solute carrier family 1 (glial high affinity glutamate transporter), member 3	11.0
11	DAG1	dystroglycan 1 (dystrophin-associated glycoprotein 1)	11.0	Publications
12	CD46	CD46 molecule, complement regulatory protein	11.0	Publications
13	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
14	GFAP	glial fibrillary acidic protein	11.0	Publications
15	ITGAM	integrin, alpha M (complement component 3 receptor 3 subunit)	11.0
16	TSPO	translocator protein (18kDa)	11.0
17	PLAUR	plasminogen activator, urokinase receptor	11.0	Publications
18	PROM1	prominin 1	11.0	Publications
19	B2M	beta-2-microglobulin	11.0	Publications
20	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
21	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
22	CD40LG	CD40 ligand	11.0	Publications
23	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Publications
24	NFKB1	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	11.0
25	NOS2	nitric oxide synthase 2, inducible	11.0
26	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
27	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
28	IL1B	interleukin 1, beta	11.0
29	MAG	myelin associated glycoprotein	11.0	Publications
30	ARSA	arylsulfatase A	11.0	Publications
31	APTX	aprataxin	11.0
32	CRYAB	crystallin, alpha B	11.0	Publications
33	POLG	polymerase (DNA directed), gamma	11.0
34	PLP1	proteolipid protein 1	11.0	Publications
35	POLR1D	polymerase (RNA) I polypeptide D, 16kDa	11.0
36	MPZ	myelin protein zero	11.0	Publications
37	DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	11.0
38	CSF2	colony stimulating factor 2 (granulocyte-macrophage)	11.0	Publications
39	MBP	myelin basic protein	11.0	Publications
40	CSF3	colony stimulating factor 3 (granulocyte)	11.0
41	TNF	tumor necrosis factor	11.0	Publications

Pathways related to nervous system disease according to GeneDecks:

(show top 50)    (show all 54)

id	Pathway	Score	Top Affiliating Genes
1	Molecular Mechanisms of Cancer36	10.5	IL6, ITGAM
2	Immune response_Bacterial infections in normal airways41	10.3	NOS2, IL1B
3	Cholinergic synapse20	10.2	CHRM2, CHRM5, CHRM1, CHRM3, CHRM4
4	Muscarinic acetylcholine receptors38	10.2	CHRM1, CHRM5
5	Regulation of actin cytoskeleton20	10.2	CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
6	Regulation of eIF4 and p70S6K36	10.0	ITGAM, IL18, IL6
7	Neuroactive ligand-receptor interaction20	9.8	CHRM2, CHRM5, CHRM1, CHRM3, CHRM4, TSPO
8	Toll-Like Receptor Signaling Pathways37	9.8	NFKB1, IL6, IL1B, IL18
9	Cytokine Network36	9.7	TNF, IL6, IL1B, IL18
10	Cytosolic DNA-sensing pathway20	9.6	POLR1D, NFKB1, IL6, IL1B, IL18
11	Immune response_MIF-mediated glucocorticoid regulation41	9.6	NFKB1, NOS2, TNF, IL6
12	Immune response MIF-mediated glucocorticoid regulation10	9.6	NFKB1, NOS2, TNF, IL6
13	African trypanosomiasis20	9.6	TNF, IL6, IL1B, IL18
14	MSP-RON Signaling36	9.6	TNF, CCL2, IL1B, IL18, ITGAM
15	IL-10 Pathway36	9.6	IL1B, IL6, TNF, NFKB1
16	Calcium signaling pathway20	9.6	CHRM2, CHRM5, CHRM1, CHRM3, NOS2
17	Amoebiasis20	9.6	CSF2, NOS2, IL6, IL1B, ITGAM
18	LDL Oxidation in Atherogenesis36	9.6	TNF, CCL2, IL1B
19	RAR-Gamma-RXR-Alpha Degradation36	9.5	CSF2, CSF3
20	Leishmaniasis20	9.5	NFKB1, NOS2, TNF, IL1B, ITGAM
21	Immune response_MIF in innate immunity response41	9.5	NFKB1, NOS2, TNF, IL6, IL1B
22	Immune response MIF in innate immunity response10	9.5	NFKB1, NOS2, TNF, IL6, IL1B
23	Immune response IL-1 signaling pathway10	9.4	NFKB1, NOS2, TNF, IL6, IL1B
24	Immune response_IL-1 signaling pathway41	9.4	IL1B, IL6, TNF, NOS2, NFKB1
25	Endothelin-1 Signaling Pathway36	9.4	IL18, IL1B, IL6, CSF3
26	NOD-like receptor signaling pathway20	9.4	NFKB1, TNF, CCL2, IL6, IL1B, IL18
27	Pertussis20	9.3	NFKB1, NOS2, TNF, IL6, IL1B, ITGAM
28	Toxoplasmosis20	9.3	CD40LG, CCR5, TNF, NOS2, NFKB1
29	Chagas disease (American trypanosomiasis)20	9.2	IL1B, IL6, CCL2, TNF, NOS2, NFKB1
30	Influenza A20	9.2	NFKB1, TNF, CCL2, IL6, IL1B, IL18
31	Tuberculosis20	9.2	NFKB1, NOS2, TNF, IL6, IL1B, IL18
32	ERK Signaling36	9.0	CSF3, NFKB1, IL6, IL1B, IL18, ITGAM
33	Rheumatoid arthritis20	9.0	CSF2, TNF, CCL2, IL6, IL1B, IL18
34	Cytokine production by Th17 cells in CF41	9.0	IL6, NFKB1, CSF2, CSF3
35	Tec Kinases Signaling36	8.9	CXCR3, NFKB1, TNF, CCR5, CCL2, IL6
36	Cytokine production by Th17 cells in CF (Mouse model)41	8.9	IL6, NFKB1, CSF2, CSF3
37	Akt Signaling36	8.8	CSF2, CXCR3, TNF, CCR5, CCL2, IL6
38	Malaria20	8.6	CD40LG, CSF3, TNF, CCL2, IL6, IL1B
39	Hematopoietic cell lineage20	8.4	CSF3, CSF2, TNF, IL6, IL1B, ITGAM
40	all-trans-Retinoic Acid Signaling in Brain36	8.2	CSF3, CSF2, TNF, CCL2, IL6, IL1B
41	PAK Pathway36	8.1	CSF3, CSF2, TNF, CCL2, IL6, IL1B
42	MIF Mediated Glucocorticoid Regulation36	8.0	CSF3, CSF2, NFKB1, TNF, CCL2, IL6
43	MIF Regulation of Innate Immune Cells36	8.0	CSF3, CSF2, NFKB1, TNF, CCL2, IL6
44	PEDF Induced Signaling36	8.0	CSF3, CSF2, NFKB1, TNF, CCL2, IL6
45	IL-6 Pathway36	8.0	CSF3, CSF2, NFKB1, TNF, CCL2, IL6
46	STAT3 Pathway36	7.9	CSF3, CSF2, CXCR3, TNF, CCR5, CCL2
47	Cytokine-cytokine receptor interaction20	7.7	CSF3, CSF2, CXCR3, TNF, CCR5, CCL2
48	Antioxidant Action of Vitamin-C36	7.7	CSF3, CSF2, CXCR3, NFKB1, TNF, CCR5
49	Rho Family GTPases36	7.7	CSF3, CSF2, GFAP, NFKB1, TNF, CCL2
50	p38 Signaling36	7.7	NFKB1, CXCR3, CSF2, CSF3, TNF, CCR5

Compounds related to nervous system disease according to GeneDecks:

(show top 50)    (show all 246)

id	Compound	Score	Top Affiliating Genes
1	pge232	10.6	PLAUR, PPARG
2	Homatropine Methylbromide9 9	11.3	CHRM1, CHRM5, CHRM2, CHRM3, CHRM4
3	Trihexyphenidyl9 9	11.3	CHRM3, CHRM1, CHRM5, CHRM2, CHRM4
4	Metixene9 9	11.3	CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
5	Cryptenamine9 9	11.3	CHRM2, CHRM5, CHRM3, CHRM4, CHRM1
6	Solifenacin9 9	11.3	CHRM2, CHRM5, CHRM1, CHRM4, CHRM3
7	Benzquinamide9 9	11.3	CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
8	darifenacin32 9 9	12.0	CHRM3, CHRM1, CHRM5, CHRM2, CHRM4
9	scopolamine32 9 18 9	13.0	CHRM5, CHRM2, CHRM3, CHRM4, TSPO, CHRM1
10	Fesoterodine9 9	11.0	CHRM4, CHRM3, CHRM1, CHRM5, CHRM2
11	tolterodine32 34 9 9	13.0	CHRM1, CHRM4, CHRM3, CHRM5, CHRM2
12	rituximab32 34 9 9	12.8	MAG, CD40LG, CSF2
13	n acetylcysteine32	9.5	MBP, PLP1, PLAUR, IL18, ITGAM
14	ivig32	9.3	CSF2, MBP, MAG, CCR5
15	endotoxin32	9.3	GC, ITGAM, IL18, PLAUR, CXCR3, CSF3
16	2,3-cyclic nucleotide32	9.0	GFAP, PLP1, MAG, MBP, MOG, MPZ
17	calcium32 9 18 9	11.9	CD46, CHRM2, CHRM1, MOG, CHRM5, CXCR3
18	mip 1alpha32	8.9	TNF, CSF2, CCL2, CCR5, IL6, IL1B
19	il-1232	8.8	CSF2, IL18, IL1B, IL6, CCL2, TNF
20	estrogen32	8.7	NOS2, IL18, GFAP, PLAUR, PPARG, APOH
21	groalpha32	8.7	IL18, IL1B, CCL2, CCR5, CSF2, IL6
22	il 1032	8.7	TNF, CCL2, CCR5, IL6, IL1B, IL18
23	thalidomide32 42 9 9	11.6	CSF2, TNF, IL6, IL1B, B2M, CD40LG
24	neopterin32	8.6	CD40LG, IL1B, IL18, CSF2, B2M, PLAUR
25	cocaine32 9 9	10.6	CD40LG, CHRM1, APOH, MBP, CCR5, PLP1
26	nitric oxide32 9 18 9	11.6	IL18, ITGAM, CD46, MOG, CXCR3, CHRM2
27	polysaccharide32	8.4	CCR5, CCL2, MAG, IL18, ARSA, CD46
28	ccl332	8.4	IL6, CCL2, CCR5, TNF, CXCR3, IL18
29	sulfatide32	8.3	GFAP, MBP, PLP1, MAG, MPZ, ARSA
30	aspartate32	8.3	CHRM3, B2M, MPZ, ARSA, IL18, MBP
31	acetylcholine32 9 18 9	11.2	MAG, MBP, IL18, CD40LG, MOG, CHRM4
32	rantes32	8.2	CD40LG, IL6, CCR5, CXCR3, CSF2, CSF3
33	gm-csf32	8.1	IL6, CSF3, CSF2, TNF, CCL2, IL1B
34	vegf32	8.1	APOH, PPARG, CCL2, GFAP, IL1B, ITGAM
35	cholesterol32 9 18 9	11.0	PLP1, PPARG, MPZ, GC, GFAP, CXCR3
36	indomethacin32 9 9	9.9	NOS2, TNF, PPARG, MBP, TSPO, PLAUR
37	creatinine32	7.9	CXCR3, TSPO, CCL2, MPZ, GC, B2M
38	genistein32 9 18 9	10.8	GFAP, NOS2, PLAUR, PPARG, CHRM1, TNF
39	histamine32 18	8.7	CHRM2, ITGAM, TNF, IL6, DDC, TSPO
40	glutamate32	7.4	CHRM1, GFAP, MBP, APOH, SLC1A3, CSF2
41	alanine32	7.1	IL18, CD40LG, IL6, CD46, ARSA, DDC
42	superoxide32 18	8.1	SLC1A3, CSF3, GFAP, GC, CXCR3, CSF2
43	lactate32	7.1	IL6, CD40LG, APOH, IL18, ITGAM, MBP
44	cyclosporin a32 42	7.9	CSF3, CCR5, TSPO, CSF2, MBP, IL6
45	glutamine32	6.9	ARSA, MBP, IL18, CCL2, CCR5, PPARG
46	dexamethasone32 42 34 9 9	10.7	CSF3, GFAP, NOS2, PLAUR, PPARG, TNF
47	lipid32	6.5	IL18, CHRM1, PROM1, GFAP, ITGAM, MOG
48	cycloheximide32	6.4	PPARG, CSF3, B2M, CSF2, GFAP, NOS2
49	retinoic acid32 42 18	8.0	CD40LG, B2M, GC, ITGAM, IL18, GFAP
50	thymidine32 18	6.9	TNF, B2M, ITGAM, IL18, IL1B, IL6

Cellular components related to nervous system disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	asymmetric synapse	GO:032279	10.3	CHRM4, CHRM3, CHRM1, CHRM2
2	axon terminus	GO:043679	10.1	CHRM4, CHRM3, CHRM1, CHRM2
3	postsynaptic membrane	GO:045211	9.7	CHRM2, CHRM5, CHRM1, CHRM3, CHRM4
4	compact myelin	GO:043218	9.5	MBP, PLP1
5	external side of plasma membrane	GO:009897	9.2	CXCR3, TNF, CCR5, CD40LG, B2M
6	neuronal cell body	GO:043025	8.9	SLC1A3, DDC, CCL2, MBP, CHRM4, CHRM2
7	cell surface	GO:009986	8.8	SLC1A3, PROM1, PLAUR, CRYAB, TNF, CCR5
8	integral to plasma membrane	GO:005887	8.3	CCR5, TNF, PLAUR, PROM1, CXCR3, CD46
9	extracellular space	GO:005615	7.1	GC, CSF3, CSF2, PROM1, DAG1, TNF
10	plasma membrane	GO:005886	6.4	MAG, CCR5, TNF, DAG1, CRYAB, PLAUR

Biological processes related to nervous system disease according to GeneDecks:

(show all 30)

id	Name	GO ID	Score	Top Affiliating Genes
1	adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway	GO:007197	10.6	CHRM5, CHRM4
2	G-protein coupled acetylcholine receptor signaling pathway	GO:007213	10.5	CHRM5, CHRM1, CHRM4
3	phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway	GO:007207	10.3	CHRM1, CHRM2
4	cellular response to interferon-gamma	GO:071346	10.2	NOS2, CCL2, IL18
5	chemokine-mediated signaling pathway	GO:070098	10.2	CCL2, CCR5, CXCR3
6	response to bacterium	GO:009617	10.2	NFKB1, NOS2, CCL2
7	regulation of vascular endothelial growth factor production	GO:010574	10.1	CCL2, IL6
8	cellular response to lipopolysaccharide	GO:071222	10.1	TSPO, NOS2, CCR5, CCL2
9	positive regulation of synaptic transmission	GO:050806	10.0	SLC1A3, TNF, CCL2
10	positive regulation of chemokine production	GO:032722	9.9	IL18, IL6, TNF
11	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.9	TNF, IL1B
12	sequestering of triglyceride	GO:030730	9.9	TNF, IL1B
13	positive regulation of interferon-gamma production	GO:032729	9.8	TNF, IL1B, IL18, CD40LG
14	lipopolysaccharide-mediated signaling pathway	GO:031663	9.7	IL18, IL1B, CCL2, TNF
15	protein kinase B signaling cascade	GO:043491	9.7	TNF, CCL2, IL1B
16	chronic inflammatory response to antigenic stimulus	GO:002439	9.7	TNF, IL1B
17	regulation of insulin secretion	GO:050796	9.7	NOS2, TNF, IL1B, CHRM3
18	positive regulation of podosome assembly	GO:071803	9.6	CSF2, TNF
19	negative regulation of gene expression	GO:010629	9.6	NOS2, PLAUR, CRYAB, TNF
20	MAPK cascade	GO:000165	9.6	TNF, CCR5, CCL2, IL1B, IL18
21	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.6	IL1B, IL6, TNF, PPARG
22	cellular response to organic cyclic compound	GO:071407	9.6	IL18, IL1B, CCL2, TNF, PPARG
23	response to glucocorticoid stimulus	GO:051384	9.5	TNF, CCL2, IL6, IL1B
24	positive regulation of interleukin-6 production	GO:032755	9.5	IL1B, IL6, TNF
25	aging	GO:007568	9.5	TSPO, CRYAB, CCL2, IL1B
26	positive regulation of heterotypic cell-cell adhesion	GO:034116	9.4	IL1B, TNF
27	response to drug	GO:042493	9.4	SLC1A3, TSPO, PPARG, TNF, CCL2, B2M
28	response to hypoxia	GO:001666	9.2	NOS2, CRYAB, TNF, CCL2, IL1B, IL18
29	anti-apoptosis	GO:006916	9.2	NFKB1, CRYAB, TNF, CCL2, IL1B, CD40LG
30	inflammatory response	GO:006954	8.9	NFKB1, TNF, CCR5, CCL2, IL6, IL1B

Molecular functions related to nervous system disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	G-protein coupled acetylcholine receptor activity	GO:016907	10.0	CHRM2, CHRM5, CHRM1, CHRM3, CHRM4
2	drug binding	GO:008144	10.0	CHRM2, CHRM1, CHRM3, PPARG
3	phosphatidylinositol phospholipase C activity	GO:004435	9.7	CCR5, CHRM3, CHRM1, CHRM5
4	cytokine activity	GO:005125	7.7	CSF3, CSF2, TNF, IL6, IL1B, IL18