MCID: NRV007
MIFTS: 70

Nervous System Disease

Categories: Neuronal diseases, Immune diseases

Aliases & Classifications for Nervous System Disease

MalaCards integrated aliases for Nervous System Disease:

Name: Nervous System Disease 12 14
Abnormality of the Nervous System 29
Nervous System Diseases 42
Nervous System Disorder 69

Classifications:



External Ids:

Disease Ontology 12 DOID:863
ICD9CM 35 349.9
MeSH 42 D009422
NCIt 47 C26835
UMLS 69 C0027765

Summaries for Nervous System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in the central nervous system or located in the peripheral nervous system.

MalaCards based summary : Nervous System Disease, also known as abnormality of the nervous system, is related to lymphoma and hemophagocytic lymphohistiocytosis, and has symptoms including aphonia, ataxia and athetosis. An important gene associated with Nervous System Disease is BACE1 (Beta-Secretase 1), and among its related pathways/superpathways are PAK Pathway and Toll-like Receptor Signaling Pathway. The drugs Benzocaine and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 72 Nervous system disease refers to a small class of medical conditions affecting the nervous... more...

Related Diseases for Nervous System Disease

Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Congenital Nervous System Abnormality
Central Nervous System Disease

Diseases related to Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 519)
id Related Disease Score Top Affiliating Genes
1 lymphoma 31.6 IFNG IL1B IL6 TLR9 TNF TRPV1
2 hemophagocytic lymphohistiocytosis 31.2 IFNG IL6 TNF
3 aspartylglucosaminuria 31.1 IFNG IL1B IL6 TNF
4 choroiditis 31.1 IL1B IL6 TNF
5 systemic lupus erythematosus 31.1 CXCR3 IFNG IL6 TLR9 TNF
6 central nervous system disease 12.4
7 peripheral nervous system disease 12.3
8 autonomic nervous system disease 12.1
9 sternal cleft 11.3 IFNG IL1B TNF
10 primary systemic mycosis 11.3 CSF2 IFNG TNF
11 scrotal carcinoma 11.3 IL1B IL6 TNF
12 cataract 11.3 CSF2 IL1B TNF
13 upper gum cancer 11.3 IL1B IL6 TNF
14 oropharyngeal cancer, childhood 11.3 CXCR3 IFNG TNF
15 bipolar i disorder 11.3 IL1B IL6 TNF
16 ovarian mucinous adenofibroma 11.3 IL1B IL6 MOG TNF
17 cyclosporiasis 11.3 CXCR3 IFNG IL6 TNF
18 indolent myeloma 11.3 IL1B IL6 TNF
19 stargardt macular degeneration absent or hypoplastic corpus callosum mental retardation and dysmorphic features 11.3 IL1B IL6 TNF
20 amyotrophic lateral sclerosis type 10 11.3 IFNG IL1B NOS2 TNF
21 lymphocytic colitis 11.3 IFNG IL6 TNF
22 pasteurellosis 11.3 CSF2 IFNG IL6 TNF
23 status epilepticus 11.3 IFNG IL1B MOG TNF
24 tracheal stenosis 11.3 IL6 MOG TNF
25 burn scar 11.3 CXCR3 IFNG IL6 TNF
26 rift valley fever 11.3 IFNG IL1B IL6 TNF
27 hepadnavirus infection 11.3 IFNG IL6 TNF
28 churg-strauss syndrome 11.3 CXCR3 IFNG IL1B TNF
29 senile reticular retinal degeneration 11.3 IFNG IL1B TNF
30 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 11.3 CSF2 IFNG TNF
31 benign eccrine breast spiradenoma 11.3 CXCR3 IFNG IL1B TNF
32 bolivian hemorrhagic fever 11.3 CXCR3 IFNG TNF
33 tinea favosa 11.3 IL1B IL6 TNF TRPV1
34 renal tubular acidosis 11.3 CSF2 CXCR3 IFNG TNF
35 ampulla of vater neoplasm 11.3 IL1B IL6 TNF
36 central nervous system leiomyosarcoma 11.3 IL1B IL6 TLR9 TNF
37 pleomorphic lipoma 11.3 IFNG IL1B IL6 TNF
38 epulis 11.3 IL1B TNF TRPV1
39 benign neonatal seizures 11.3 IL1B IL6 TNF
40 blue toe syndrome 11.3 IFNG IL1B IL6 TNF
41 acute vascular insufficiency of intestine 11.3 CXCR3 IFNG TLR9 TNF
42 keloids 11.3 IL1B IL6 TNF
43 scabies 11.3 IFNG IL1B IL6 TNF
44 neonatal jaundice 11.3 IFNG IL6 MOG TNF
45 myeloid sarcoma 11.3 IL1B IL6 TLR9 TNF
46 dysphagia 11.3 IFNG IL6 TNF
47 ostertagiasis 11.3 IL1B IL6 TLR9 TNF
48 diffuse glomerulonephritis 11.3 CXCR3 IFNG IL6
49 mikulicz disease 11.3 IL1B IL6 TLR9 TNF
50 breast disease 11.3 IL1B IL6 TLR9 TNF

Comorbidity relations with Nervous System Disease via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Nervous System Disease:



Diseases related to Nervous System Disease

Symptoms & Phenotypes for Nervous System Disease

UMLS symptoms related to Nervous System Disease:


aphonia, ataxia, athetosis, back pain, cerebellar ataxia, cheyne-stokes respiration, dizziness, muscular fasciculation, headache, hemiparesis, hemiplegia, hoarseness, hyperalgesia, hyperesthesia, leg cramps, meningism, flaccid muscle tone, muscle rigidity, muscle spasticity, myoclonus, neuralgia, numbness, ophthalmoplegia, pain, paresis, reflex, abnormal, sciatica, seizures, spasm, pathological conditions, signs and symptoms, syncope, torticollis, tremor, vertigo, flaccid paralysis, burning sensation, hypalgesia, agitation, lassitude, chronic pain, scalp tenderness, cogwheel rigidity, opisthotonus, circumoral paresthesia, spasmodic torticollis, lightheadedness, muscular stiffness, musculoskeletal symptom, muscular incoordination, muscle fibrillation, asterixis, bradykinesia, micropsia, clumsiness, asynergia, adiadochokinesis, fine tremor, coarse tremor, action tremor, epileptic aura, lid retraction, application site anesthesia, injection site anesthesia, spasm oropharyngeal, astasia, dysdiadochokinesis, fumbling, head discomfort, head pressure, head tightness, hypersensation skin, bulging fontanelle, numbness localized, neurologic symptoms, paresthesia, distal, paresthesia mucosal, paresthesia skin, tingling of skin, skeletal muscle paralysis, paralysis muscle general skeletal, paralysis muscle local skeletal, paralysis lower motor neuron type, scotoma, scintillating, tongue sluggish, tremor, perioral, tremor, muscle, nerve tremors, dyskinesia neonatal, tremor, neonatal, absence attacks, anesthesia mouth, anesthesia lip, anesthesia oral mucosa, anesthesia tongue, burning sensation of skin, post-lumbar puncture headache, seizures, tonic, extreme exhaustion, agitation mental, akathisia, dysesthesia, rigor - temperature-associated observation, involuntary movements, vertigo/dizziness, abnormal coordination, burning mucosal, paresthesia mouth, numb mouth, eyes rolling, electric shock sensation, jaw stiffness, equilibration disorder, muzzy headed, clouded consciousness, motor restlessness, decreased tendon reflex, myotonus (finding), reaction to spinal or lumbar puncture, staggering gait, non-epileptic convulsion, gait ataxia, headache fullness, sleeplessness, symptoms

MGI Mouse Phenotypes related to Nervous System Disease:

44 (show all 20)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.51 APOE APP BACE1 CCR1 CSF2 CXCR3
2 homeostasis/metabolism MP:0005376 10.44 GC IFNG IL1B IL6 MTDH NOS2
3 immune system MP:0005387 10.4 CCR1 CSF2 CXCR3 IFNG IL1B IL6
4 hematopoietic system MP:0005397 10.39 IL6 MOG MTDH NOS2 PRNP TLR9
5 mortality/aging MP:0010768 10.38 APOE APP BACE1 CCR1 CSF2 CXCR3
6 behavior/neurological MP:0005386 10.37 NOS2 PRNP PROM1 TNF TRPV1 APOE
7 cardiovascular system MP:0005385 10.36 APOE CCR1 CSF2 CXCR3 IFNG IL1B
8 growth/size/body region MP:0005378 10.34 APOE APP BACE1 CSF2 IFNG IL6
9 integument MP:0010771 10.29 APOE APP BACE1 CSF2 IFNG IL1B
10 nervous system MP:0003631 10.28 APOE APP BACE1 CSF2 IFNG IL1B
11 endocrine/exocrine gland MP:0005379 10.22 APOE CSF2 GC IFNG IL6 MTDH
12 neoplasm MP:0002006 10.13 CSF2 CXCR3 IFNG IL1B IL6 MTDH
13 muscle MP:0005369 10.11 APOE APP BACE1 IFNG IL6 MOG
14 liver/biliary system MP:0005370 10.1 APOE CCR1 IFNG IL6 MTDH NOS2
15 no phenotypic analysis MP:0003012 9.97 TNF TRPV1 APOE APP BACE1 IFNG
16 renal/urinary system MP:0005367 9.97 IL6 NOS2 TLR9 TRPV1 APOE CCR1
17 reproductive system MP:0005389 9.91 APOE APP CSF2 IFNG IL6 MTDH
18 respiratory system MP:0005388 9.81 APOE CCR1 CSF2 CXCR3 IFNG IL6
19 skeleton MP:0005390 9.61 IL6 NOS2 PRNP TNF APOE CSF2
20 vision/eye MP:0005391 9.28 APOE IFNG IL6 MFRP MOG NOS2

Drugs & Therapeutics for Nervous System Disease

Drugs for Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1415)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 1994-09-7, 94-09-7 2337
2
Hydroxocobalamin Approved Phase 4,Phase 3,Phase 2 13422-51-0 11953898 5460373 44475014
3
Metformin Approved Phase 4,Phase 3 657-24-9 14219 4091
4
Rivastigmine Approved, Investigational Phase 4,Phase 2,Phase 1 123441-03-2 77991
5
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 2078-54-8 4943
6
Sevoflurane Approved, Vet_approved Phase 4,Phase 3,Phase 2 28523-86-6 5206
7
Imipramine Approved Phase 4,Phase 3 50-49-7 3696
8
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 148553-50-8 5486971
9
Lamotrigine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 84057-84-1 3878
10
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 99-66-1 3121
11
Citalopram Approved Phase 4,Phase 2,Phase 1 59729-33-8 2771
12
Moxonidine Approved Phase 4 75438-57-2 4810
13
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
14
Levodopa Approved Phase 4,Phase 3,Phase 2,Phase 1 59-92-7 6047
15
Baclofen Approved Phase 4,Phase 3,Phase 2,Phase 1 1134-47-0 2284
16
Udenafil Approved, Investigational Phase 4 268203-93-6 6918523
17
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 6740-88-1 3821
18
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
19
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 2180-92-9, 38396-39-3 2474
20
Ropivacaine Approved Phase 4,Phase 3,Early Phase 1 84057-95-4 71273 175805
21
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
22
Etomidate Approved Phase 4 33125-97-2 36339 667484
23
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 437-38-7 3345
24
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 59467-70-8 4192
25
Remifentanil Approved Phase 4,Phase 3,Phase 2,Phase 1 132875-61-7 60815
26
Rocuronium Approved Phase 4,Phase 1,Phase 2 119302-91-9, 143558-00-3 441290
27
Haloperidol Approved Phase 4 52-86-8 3559
28
Meperidine Approved Phase 4,Phase 2,Phase 3 57-42-1 4058
29
Lidocaine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 137-58-6 3676
30
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-27-2 5288826
31
Terbutaline Approved Phase 4,Phase 2 23031-25-6 5403
32
Etoricoxib Approved, Investigational Phase 4,Phase 3 202409-33-4 123619
33
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1 76-42-6 5284603
34
Hydromorphone Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 466-99-9 5284570
35
Amitriptyline Approved Phase 4,Phase 3,Phase 2 50-48-6 2160
36
Cyclobenzaprine Approved Phase 4,Phase 3 303-53-7 2895
37
Hydrocodone Approved, Illicit Phase 4,Phase 3,Phase 2 125-29-1 5284569
38
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
39
Aprepitant Approved, Investigational Phase 4,Early Phase 1 170729-80-3 151165 6918365
40
Fosaprepitant Approved Phase 4,Early Phase 1 172673-20-0 219090
41
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-84-3 187
42
Coal tar Approved Phase 4,Phase 2,Phase 1 8007-45-2
43
Alfuzosin Approved, Investigational Phase 4 81403-80-7 2092
44
Tamsulosin Approved, Investigational Phase 4,Phase 1 106133-20-4 129211
45
Timolol Approved Phase 4,Phase 2,Phase 1 26839-75-8 33624 5478
46
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 69-65-8 453 6251
47
Ketorolac Approved Phase 4,Phase 3,Phase 2,Phase 1 74103-06-3, 66635-83-4 3826
48
Metoclopramide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 364-62-5 4168
49
Milnacipran Approved Phase 4,Phase 3,Phase 2 92623-85-3 65833
50
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 2,Phase 1 58-93-5 3639

Interventional clinical trials:

(show top 50) (show all 10000)

id Name Status NCT ID Phase Drugs
1 Normal Oxygenation Versus Hyperoxia in the Intensive Care Unit (ICU) Unknown status NCT01319643 Phase 4 Oxygen
2 Controlled Trial of Deep Brain Stimulation in Early Patients With Parkinson's Disease Unknown status NCT00354133 Phase 4
3 Antispastic Effect of Transcranial Magnetic Stimulation in Patients With Cerebral and Spinal Spasticity Unknown status NCT01786005 Phase 4
4 How Many Patients Are in Need of Vitamin B12 Injections? Unknown status NCT00326833 Phase 4 vitamin B12
5 Metformin for Weight Control in Adolescents Taking Atypical Antipsychotics Unknown status NCT00845936 Phase 4 Metformin
6 Glucagon Like Peptides Receptors Expression in the Stomach of Diabetes Type 2 Unknown status NCT00473733 Phase 4
7 Bi-Axial Rotating Magnetic Field Therapy in Refractory Neuropathic Foot Pain Secondary to Diabetic Peripheral Neuropathy Unknown status NCT00123136 Phase 4
8 Cognitive Decline in Non-demented PD Unknown status NCT01340885 Phase 4 Strattera;Exelon
9 Anesthesia Induction in Patients Undergoing Surgery for Cervical Myelopathy Unknown status NCT01052337 Phase 4 anaesthetics: sevofluorane
10 ShuntCheck-Micro-Pumper Pediatric Clinical Outcomes Study Unknown status NCT01881711 Phase 4
11 Inspiratory Muscle Training in Patients With Autonomic Neuropathic Unknown status NCT00752440 Phase 4
12 Major Depressive Disorder - Understanding The Link Between The Brain And The Heart Unknown status NCT01568307 Phase 4 Participants will be prescribed an approved selective serotonin re-uptake inhibitor (SSRI) antidepressant.
13 Oxepa in Multiple Trauma Unknown status NCT01099501 Phase 4
14 NIMIP: Non Invasive Measurement of the Intracranial Pressure Unknown status NCT01685450 Phase 4
15 A Post-marketing Evaluation of a Compound Traditional Chinese Herbal Medicine, Qishe Pill, on Cervical Radiculopathy Unknown status NCT01875562 Phase 4 Qishe Pill
16 Imipramine and Pregabalin Combination in Painful Polyneuropathy Unknown status NCT01047488 Phase 4 Imipramine;Pregabalin;Imipramine, pregabalin;Placebo
17 Hormone Profiles in Adults With Newly Diagnosed Epilepsy Unknown status NCT00137709 Phase 4 Sodium valproate;Lamotrigine
18 Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder (MDD) Unknown status NCT01483053 Phase 4 Agomelatine;Escitalopram
19 The Impact of Reducing Overtreatment on Quality of Life in Children With Refractory Epilepsy Unknown status NCT00647322 Phase 4
20 Study to Improve the Treatment of Epilepsy (SITE) Unknown status NCT00133081 Phase 4 All registered antiepileptic drugs
21 Sympathetic Nervous System Inhibition for the Treatment of Diabetic Kidney Disease Unknown status NCT01094769 Phase 4 Moxonidine;Placebo
22 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
23 Compare Tolerability of an Overnight Switch to Gradual Switch Between Two Different Forms of Depakote Unknown status NCT00312676 Phase 4
24 Eyegaze Systems for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943656 Phase 4
25 Exoskeletons for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943669 Phase 4
26 Functional Electrical Stimulation-Assisted Walking: Reduction of Secondary Complications Due to Spinal Cord Injury Unknown status NCT00201968 Phase 4
27 Does Oral Baclofen Improve Care and Comfort in Spastic Children in Nursing Homes? Unknown status NCT00752934 Phase 4 oral baclofen + placebo;placebo + oral baclofen
28 Sleep Disturbances in Hospitalized Children Unknown status NCT00749814 Phase 4
29 Understanding of Chest Pain in Microvascular Disease Proved by Cardiac Magnetic Resonance Image Unknown status NCT01769482 Phase 4 Udenafil;placebo
30 Study on Magnetic Field Therapy to Improve Chronic Lumbar Pain Unknown status NCT00444990 Phase 4
31 Effect of Ketalar to Prevent Postoperative Chronic Pain After Mastectomy Unknown status NCT00129597 Phase 4 ketalar
32 Paracetamol for Cancer Pain Unknown status NCT01313247 Phase 4 paracetamol;placebo tablets
33 Effect of Rozerem on Sleep Among People With Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
34 A Trial Comparing Adductor Canal Catheter and Intraarticular Catheter Following Primary Total Knee Arthroplasty Unknown status NCT02497911 Phase 4 Ropivicaine;Bupivicaine
35 Bilateral Superficial Cervical Block for Thyroidectomy Unknown status NCT01171885 Phase 4 0.9% saline;Ropivacaine;Ropivacaine
36 Effects and Mechanism of Pretreatment With Dexmedetomidine to Etomidate Induce Myoclonus Unknown status NCT02518789 Phase 4 Low-dose Dexmedetomidine;High-dose dexmedetomidine;normal saline;Etomidate;midazolam,fentanyl,rocuronium;propofol,remifentanil,cis atracurium
37 Birth Ball Versus Meperidine and Haloperidol Injection for Pain Relief During First Stage of Labour Unknown status NCT02493192 Phase 4 pethidine and haloperidol injection
38 The Effect of Ketamine Infusion on Lumbar Surgery Unknown status NCT02154438 Phase 4 Ketamine
39 Effect of Pre-injection of Lidocaine on Myoclonus Induced by Induction With Etomidate in Elderly Patients During General Anesthesia Unknown status NCT02141737 Phase 4 Lidocaine Hydrochloride Injection;Etomidate Fat Emulsion Injection;normal saline;Midazolam Injection;Fentanyl Citrate Injection;Rocuronium Injection
40 A Comparison of Morphine and Morphine Plus Dexmedetomidine in Chronic Cancer Pain Unknown status NCT02289261 Phase 4 Morphine;Morphine plus dexmedetomidine
41 Intravenous Terbutaline to Facilitate Labor Epidural Catheter Placement Unknown status NCT01651962 Phase 4 Terbutaline;Fentanyl;0.9% NaCl
42 Evaluation of the Efficacy and Tolerability of Etoricoxib Monotherapy Versus Combination Oxycodone-etoricoxib in Moderate to Severe Pain From Chronic Low Back Pain Unknown status NCT01344720 Phase 4 etoricoxib;oxycodone
43 Trial Comparing Morphine to Hydromorphone in Elderly Patients With Severe Pain Unknown status NCT00305058 Phase 4 Morphine 0.05 mg/kg Intravenous;Hydromorphone 0.0075 mg/kg intravenous
44 A Randomized Study of Three Medication Regimens for Acute Low Back Pain Unknown status NCT01587274 Phase 4 Naproxen;Cyclobenzaprine;Oxycodone/ acetaminophen
45 Pilot Study of Sedation With Propofol in Refractory Pains Due to Care in Palliative Care Unit Unknown status NCT02198404 Phase 4 sedation with propofol
46 Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH) Unknown status NCT02347878 Phase 4 Aprepitant
47 Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache Unknown status NCT00752921 Phase 4 etoricoxib;placebo
48 Interaction of Statins and Nondepolarizing Muscle Relaxants Unknown status NCT02222519 Phase 4 Rocuronium
49 Botulinum Toxin A for the Treatment of Chronic Lumbar Back Pain Unknown status NCT00404417 Phase 4 Botulinum Toxin A / Placebo;Botulinum Toxin A / Botulinum Toxin A;Placebo / Botulinum Toxin A;Placebo / Placebo
50 Management of Chronic Pain in Military Patients With Injuries Sustained During Active Duty Unknown status NCT01616342 Phase 4

Search NIH Clinical Center for Nervous System Disease

Cochrane evidence based reviews: nervous system diseases

Genetic Tests for Nervous System Disease

Genetic tests related to Nervous System Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Nervous System 29

Anatomical Context for Nervous System Disease

MalaCards organs/tissues related to Nervous System Disease:

39
Brain, Spinal Cord, Testes, Bone, Breast, Heart, Eye

Publications for Nervous System Disease

Articles related to Nervous System Disease:

(show top 50) (show all 355)
id Title Authors Year
1
Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study. ( 28471963 )
2017
2
Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening. ( 28075486 )
2017
3
Central Nervous System Disease, Education, and Race Impact Radiation Refusal in Pediatric Cancer Patients. ( 28538508 )
2017
4
Central nervous system disease in pediatric acute myeloid leukemia: A report from the Children's Oncology Group. ( 28453910 )
2017
5
Central nervous system disease in pediatric acute myeloid leukemia. ( 28853216 )
2017
6
Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. ( 28288111 )
2017
7
Is the Eye an Extension of the Brain in Central Nervous System Disease? ( 28609158 )
2017
8
Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense infection. ( 28927234 )
2017
9
Occupational exposure to extremely low-frequency magnetic fields and risk for central nervous system disease: an update of a Danish cohort study among utility workers. ( 28429106 )
2017
10
Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii. ( 28933846 )
2017
11
Wasp Venom Immunotherapy in a Patient With Immune-Mediated Inflammatory Central Nervous System Disease: Is it Safe? ( 28398199 )
2017
12
Mesencephalic astrocyte-derived neurotrophic factor and its role in nervous system disease. ( 28685189 )
2017
13
Glial biomarkers in human central nervous system disease. ( 27228454 )
2016
14
Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses. ( 26861818 )
2016
15
Central nervous system disease in childhood acute lymphoblastic leukaemia- a review. ( 26990196 )
2016
16
Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe'sA disease). ( 27638585 )
2016
17
Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia. ( 26997880 )
2016
18
Fatal Central Nervous System Disease Following First Infliximab Infusion in a Child With Inflammatory Bowel Disease. ( 26831951 )
2016
19
An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease. ( 26843629 )
2016
20
The effects of diet on the severity of central nervous system disease: One part of lab-to-lab variability. ( 27133811 )
2016
21
Clinical and Laboratory Findings That Differentiate Herpes Simplex Virus Central Nervous System Disease from Enteroviral Meningitis. ( 27563314 )
2016
22
AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage-Th17 Axis. ( 27354217 )
2016
23
Raccoon Roundworm Infection Associated with Central Nervous System Disease and Ocular Disease - Six States, 2013-2015. ( 27608169 )
2016
24
Delivery of an adeno-associated virus vector into CSF attenuates central nervous system disease in mucopolysaccharidosis type II mice. ( 27510804 )
2016
25
Hodgkin Lymphoma With Central Nervous System Disease at Primary Presentation. ( 26814676 )
2016
26
Association of Resident Duty Hour Restrictions on Mortality of Nervous System Disease and Disorder. ( 27777670 )
2016
27
Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII. ( 26447927 )
2015
28
Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques. ( 25672885 )
2015
29
Recurrent neonatal herpes simplex virus infection with central nervous system disease after completion of a 6-month course of suppressive therapy: Case report. ( 26390826 )
2015
30
Diagnostic value of aquaporin 4 antibody in assessing idiopathic inflammatory demyelinating central nervous system diseases in Egyptian patients. ( 25677878 )
2015
31
Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease. ( 25474439 )
2015
32
Intranasal delivery of stem cells as therapy for central nervous system disease. ( 25645932 )
2015
33
Flow cytometry for detection of central nervous system disease in acute myeloid leukemia. ( 25641427 )
2015
34
Interaction between Tat and Drugs of Abuse during HIV-1 Infection and Central Nervous System Disease. ( 26793168 )
2015
35
Targeted Temperature Management in Pediatric Central Nervous System Disease. ( 26042193 )
2015
36
Systemic Therapy for HER2-Positive Central Nervous System Disease: Where We Are and Where Do We Go From Here? ( 26314739 )
2015
37
Distinct systemic and central nervous system disease patterns in enterovirus and parechovirus infected children. ( 24662038 )
2014
38
ELR(+) chemokine signaling in host defense and disease in a viral model of central nervous system disease. ( 24987333 )
2014
39
Evaluation of malnutrition in patients with nervous system disease. ( 25192880 )
2014
40
RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease. ( 25258010 )
2014
41
Coxsackievirus-induced acute neonatal central nervous system disease model. ( 24696707 )
2014
42
Neonatal Herpes Simplex Virus Type-1 Central Nervous System Disease with Acute Retinal Necrosis. ( 24378951 )
2014
43
Current developments in understanding of West Nile virus central nervous system disease. ( 24722324 )
2014
44
A coumarin-based fluorescent probe as a central nervous system disease biomarker. ( 25390405 )
2014
45
Attribution in the assessment of nervous system disease in SLE. ( 25480812 )
2014
46
The role of AEG-1/MTDH/LYRIC in the pathogenesis of central nervous system disease. ( 23889991 )
2013
47
HIV-Associated Central Nervous System Disease in Patients Admitted at the Douala General Hospital between 2004 and 2009: A Retrospective Study. ( 23533732 )
2013
48
Epstein-Barr virus (EBV) load in cerebrospinal fluid and peripheral blood of patients with EBV-associated central nervous system diseases after allogeneic hematopoietic stem cell transplantation. ( 23692640 )
2013
49
Long non-coding RNAs: novel targets for nervous system disease diagnosis and therapy. ( 23817781 )
2013
50
RON receptor tyrosine kinase, a negative regulator of inflammation, is decreased during simian immunodeficiency virus-associated central nervous system disease. ( 24043899 )
2013

Variations for Nervous System Disease

Expression for Nervous System Disease

Search GEO for disease gene expression data for Nervous System Disease.

Pathways for Nervous System Disease

Pathways related to Nervous System Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.32 CCR1 CSF2 CXCR3 IL1B IL6 TNF
2
Show member pathways
12.89 IFNG IL1B IL6 NOS2 TLR9 TNF
3
Show member pathways
12.8 IFNG IL1B IL6 TLR9 TNF
4
Show member pathways
12.74 APP IFNG IL1B IL6 TNF
5
Show member pathways
12.61 IFNG IL1B IL6 NOS2 TNF
6 12.58 APOE APP BACE1 PRNP TUBB3
7
Show member pathways
12.45 CSF2 IFNG IL1B IL6 TNF
8
Show member pathways
12.35 CSF2 IFNG IL1B IL6 TNF
9
Show member pathways
12.28 IFNG IL1B NOS2 TNF
10
Show member pathways
12.28 IFNG IL1B IL6 NOS2 TNF
11 12.21 IFNG IL1B IL6 NOS2 TLR9 TNF
12 12.2 IFNG IL6 NOS2 TLR9 TNF
13
Show member pathways
12.18 IFNG IL1B IL6 TNF
14
Show member pathways
12.15 IFNG IL1B IL6 NOS2 TLR9 TNF
15 12.03 IFNG IL1B IL6 NOS2 TNF
16 12.01 CCR1 CSF2 IFNG IL6 TNF
17 12 IL1B IL6 NOS2 TNF
18 11.97 CSF2 IL1B IL6 TNF
19
Show member pathways
11.96 IFNG IL1B IL6 TLR9 TNF
20
Show member pathways
11.93 IFNG IL1B IL6 TLR9
21 11.92 CSF2 IL1B IL6 TNF
22 11.86 CSF2 IFNG IL1B IL6 TNF
23 11.83 CSF2 IFNG IL1B IL6 NOS2
24 11.82 CXCR3 IFNG IL1B TNF
25 11.8 CSF2 IFNG IL6
26 11.79 IL1B IL6 NOS2 TNF
27 11.78 CSF2 IFNG IL1B IL6 NOS2 TNF
28
Show member pathways
11.77 CSF2 IFNG TNF
29 11.74 IL6 NOS2 TLR9 TNF
30 11.68 CSF2 IL1B IL6 TNF
31 11.61 IFNG IL6 NOS2
32 11.61 IL1B IL6 TNF
34 11.6 APP BACE1 PRNP
35 11.57 IFNG IL6 TNF
36 11.55 IFNG IL1B NOS2 TNF
37 11.54 IFNG IL1B TNF
38 11.54 CSF2 IL1B IL6
39 11.52 CCR1 CSF2 IL1B IL6 TNF
40 11.51 APOE APP BACE1
41 11.49 IFNG IL1B IL6 TLR9 TNF
42
Show member pathways
11.44 CSF2 IFNG TNF
43 11.42 APOE IFNG IL1B IL6 TNF
44 11.41 IFNG IL1B NOS2
45 11.38 IL1B IL6 TNF
46 11.37 IL1B IL6 PRNP
47 11.33 IFNG IL1B IL6 TNF
48 11.32 IL1B IL6 TNF
49 11.31 CSF2 IFNG IL1B IL6 TLR9 TNF
50 11.23 CSF2 IL1B IL6 TNF

GO Terms for Nervous System Disease

Cellular components related to Nervous System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 APOE APP CSF2 GC IFNG IL1B
2 cell surface GO:0009986 9.63 APP BACE1 CXCR3 PRNP PROM1 TNF
3 membrane raft GO:0045121 9.56 APP BACE1 PRNP TNF
4 external side of plasma membrane GO:0009897 9.1 CCR1 CXCR3 IFNG IL6 TNF TRPV1

Biological processes related to Nervous System Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
id Name GO ID Score Top Affiliating Genes
1 defense response to bacterium GO:0042742 9.99 IFNG NOS2 TLR9 TNF
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.95 IL1B MTDH TLR9 TNF
3 positive regulation of protein phosphorylation GO:0001934 9.95 APP IFNG IL1B TNF
4 defense response to Gram-negative bacterium GO:0050829 9.89 IL6 NOS2 TLR9
5 cellular response to drug GO:0035690 9.87 IL1B NOS2 PRNP
6 inflammatory response GO:0006954 9.87 CCR1 CXCR3 IL1B IL6 TLR9 TNF
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.86 CSF2 IFNG IL6
8 positive regulation of T cell proliferation GO:0042102 9.85 IFNG IL1B IL6
9 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL1B IL6 MTDH TLR9 TNF
10 humoral immune response GO:0006959 9.84 IFNG IL6 TNF
11 negative regulation of gene expression GO:0010629 9.83 CCR1 IFNG NOS2 TNF
12 positive regulation of gene expression GO:0010628 9.8 APP CSF2 IFNG IL1B IL6 TLR9
13 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.79 CSF2 IL1B TNF
14 regulation of insulin secretion GO:0050796 9.78 IFNG IL1B NOS2 TNF
15 lipopolysaccharide-mediated signaling pathway GO:0031663 9.77 IL1B MTDH TNF
16 cellular response to lipopolysaccharide GO:0071222 9.77 CSF2 IFNG IL6 NOS2 TNF
17 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.75 IL1B IL6 TNF
18 positive regulation of interleukin-8 production GO:0032757 9.74 IL1B TLR9 TNF
19 positive regulation of NF-kappaB import into nucleus GO:0042346 9.72 IL1B TLR9 TNF
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.71 IL1B TNF
21 positive regulation of protein import into nucleus, translocation GO:0033160 9.71 IFNG IL6
22 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.71 IL6 TNF
23 positive regulation of podosome assembly GO:0071803 9.71 CSF2 TNF
24 positive regulation of osteoclast differentiation GO:0045672 9.71 CCR1 IFNG TNF
25 positive regulation of interleukin-6 production GO:0032755 9.71 IL1B IL6 TLR9 TNF
26 negative regulation of interleukin-17 production GO:0032700 9.7 IFNG PRNP
27 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.7 IL1B TLR9
28 negative regulation of lipid storage GO:0010888 9.69 IL6