MCID: NRV007
MIFTS: 50

Nervous System Disease malady

Neuronal diseases, Immune diseases categories
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Summaries for Nervous System Disease

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A disease of anatomical entity that is located in the central nervous system or located in the peripheral nervous system.

MalaCards: Nervous System Disease, also known as nervous system disorder, is related to central nervous system disease and encephalomyelitis. An important gene associated with Nervous System Disease is MOG (myelin oligodendrocyte glycoprotein). The compounds oleic acid and fmlp have been mentioned in the context of this disorder. Affiliated tissues include the central nervous system or, brain and t cells.

Wikipedia:65 Nervous system disease refers to a general class of medical conditions affecting the nervous system. more...

Aliases & Classifications for Nervous System Disease

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH, 27ICD9CM, 25ICD10
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Related Diseases for Nervous System Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Autoimmune Disease of the Nervous System
Central Nervous System Disease Congenital Nervous System Abnormality

Diseases related to Nervous System Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 279)
idRelated DiseaseScoreTop Affiliating Genes
1central nervous system disease31.7MOG, CXCR3
2encephalomyelitis30.5MOG, CXCR3
3multiple sclerosis30.2CXCR3, MOG, GC, CD46
4subacute sclerosing panencephalitis30.1CD46, MOG
5systemic lupus erythematosus10.4
6lupus erythematosus10.4
7peripheral nervous system disease10.3
8leukemia10.3
9measles10.3
10lymphocytic choriomeningitis10.3
11langerhans-cell histiocytosis10.2
12histiocytosis10.2
13pneumonia10.2
14myopathy due to calsequestrin and serca1 protein overload10.2
15autonomic nervous system disease10.2
16neuropathy10.2
17stomatitis10.2
18hiv-110.2
19myotonia congenita, atypical, acetazolamide-responsive10.2
20kaposi's sarcoma10.1
21cerebritis10.1
22acute myeloid leukemia10.1
23central core myopathy10.1
24arthritis10.1
25herpes simplex10.1
26lymphoblastic leukemia10.1
27myeloid leukemia10.1
28sarcoma10.1
29rigid spine syndrome10.1
30emery-dreifuss muscular dystrophy 2, ad10.1
31hematopoietic stem cell transplantation10.1
32neuronitis10.0
33metachromatic leukodystrophy10.0
34acquired immunodeficiency syndrome10.0
35mumps10.0
36lambert-eaton myasthenic syndrome10.0
37psoriatic arthritis10.0
38congenital muscular dystrophy10.0
39hepatitis10.0
40hodgkin's lymphoma10.0
41leukodystrophy10.0
42retinitis10.0
43vasculitis10.0
44calpainopathy10.0
45myopathy with postural muscle atrophy, x-linked10.0
46centronuclear myopathy 410.0
47melas, mt-th-related10.0
48myasthenic syndrome, congenital, with pre- and postsynaptic defects10.0
49erythrocyte lactate transporter defect10.0
50muscular dystrophy-dystroglycanopathy , type b, 1410.0

Graphical network of the top 20 diseases related to Nervous System Disease:



Diseases related to nervous system disease

Symptoms for Nervous System Disease

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Drugs & Therapeutics for Nervous System Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Nervous System Disease

Search NIH Clinical Center for Nervous System Disease

Genetic Tests for Nervous System Disease

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Anatomical Context for Nervous System Disease

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Nervous System Disease:

33
Brain, T cells, Testes, Myeloid, Skin, Bone marrow, Bone, B cells, Pituitary, Liver, Kidney

FMA organs/tissues related to Nervous System Disease:

14
The central nervous system or

Animal Models for Nervous System Disease or affiliated genes

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Publications for Nervous System Disease

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Sources:
52PubMed
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Articles related to Nervous System Disease:

(show top 50)    (show all 309)
idTitleAuthorsYear
1
Cytogenetic profile of patients with acute myeloid leukemia and central nervous system disease. (21692072)
2012
2
Post-transplant lymphoproliferative disorder: the significance of central nervous system disease. (22717024)
2012
3
Gut, bugs, and brain: role of commensal bacteria in the control of central nervous system disease. (21387369)
2011
4
Screening for central nervous system disease in metastatic gestational trophoblastic neoplasia. (20795342)
2010
5
Significance of surface epithelial cells in canine cerebrospinal fluid and relationship to central nervous system disease. (20727124)
2010
6
Coexistence of psoriatic arthritis and collagenous colitis with inflammatory nervous system disease. (18538620)
2008
7
Neural progenitors and HIV-1-associated central nervous system disease in adults and children. (16842084)
2006
8
PPARgamma as a therapeutic target in central nervous system diseases. (16766086)
2006
9
Disseminating anaplastic brainstem oligodendroglioma associated with allelic loss in the tumor suppressor candidate region D19S246 of chromosome 19 mimicking an inflammatory central nervous system disease in a 9-year-old boy. (16084959)
2005
10
Central nervous system disease in primary Sjogrens syndrome: the role of magnetic resonance imaging. (15609267)
2004
11
No gender differences in the progression of nervous system disease in HIV infection. (15213565)
2004
12
Update on neuroimaging in infectious central nervous system disease. (15247545)
2004
13
Rebuilding an immune-mediated central nervous system disease: weighing the pathogenicity of antigen-specific versus bystander T cells. (15470017)
2004
14
Concurrent syrinx and inflammatory central nervous system disease detected by magnetic resonance imaging: an illustrative case and review of the literature. (11807404)
2002
15
Laboratory diagnosis of human cytomegalovirus (HCMV) central nervous system disease in AIDS patients. (11118856)
2000
16
HIV-1 and its causal relationship to immunosuppression and nervous system disease in AIDS: a review. (11070121)
2000
17
Melanocortins and the treatment of nervous system disease. Potential relevance to the skin? (10816665)
1999
18
Cloning the antibody response in humans with inflammatory central nervous system disease: analysis of the expressed IgG repertoire in subacute sclerosing panencephalitis brain reveals disease-relevant antibodies that recognize specific measles virus antigens. (10477623)
1999
19
Primary SjAPgren's syndrome with severe central nervous system disease. (10468410)
1999
20
Possible concomitant fibromyalgia in systemic lupus erythematosus patients with overt central nervous system disease but with cognitive deficits: comment on the article by Kozora et al. (9259439)
1997
21
Anti-intercellular adhesion molecule-1 (ICAM-1) antibody treatment prevents central and peripheral nervous system disease in autoimmune-prone mice. (9364423)
1997
22
Gene transfer and delivery in central nervous system disease. (15104414)
1997
23
Analysis of cognitive and psychological deficits in systemic lupus erythematosus patients without overt central nervous system disease. (8961909)
1996
24
Association of antiphospholipid antibodies with central nervous system disease in systemic lupus erythematosus. (7573096)
1995
25
Differential effects of CD4+ T cell depletion on inflammatory central nervous system disease, arthritis and sialadenitis in MRL/lpr mice. (7612146)
1995
26
Cerebrospinal fluid analysis in systemically ill children without central nervous system disease. (7596721)
1995
27
The significance of in-situ Ia antigen expression in the pathogenesis of autoimmune central nervous system disease. (8397714)
1993
28
Capillary-zone electrophoretic analyses of the proteins and amino acid components in cerebrospinal fluid of central nervous system diseases. (8287042)
1993
29
Central nervous system disease in acute lymphoblastic leukemia. (8443045)
1993
30
Autoreactive T and B cells in nervous system diseases. (8382894)
1993
31
Nervous system disease, immunological features, and HLA phenotype in SjAPgren's syndrome. (1586250)
1992
32
Amyloid in central nervous system disease. (1963819)
1990
33
Beta-endorphin alters the course of central nervous system disease induced by a temperature-sensitive vesicular stomatitis virus in reconstituted nude mice. (2160476)
1990
34
Anaesthesia and central nervous system disease in small animals. Part II: Anaesthetic management for specific diseases and procedures. (2204465)
1990
35
Central nervous system disease: a dental diagnosis? (3268641)
1988
36
Cyclic esotropia with central nervous system disease: report of two cases. (3681610)
1987
37
Mouse hepatitis virus type 4 (JHM strains). induced fatal central nervous system disease. I. genetic control and murine neuron as the susceptible site of disease. (6265583)
1981
38
Raccoon ascarid larvae as a cause of fatal central nervous system disease in subhuman primates. (7199033)
1981
39
Blunted TSH response to TRH in patients with central nervous system disease. (6787920)
1981
40
Giant axonal neuropathy: combined central and peripheral nervous system disease. (217319)
1979
41
Central nervous system disease. (509758)
1979
42
The effect of neonatal thymectomy on Tamiami virus-induced central nervous system disease. (1123649)
1975
43
Bromide partition test in the evaluation of the blood-cerebrospinal barrier in children with congenital hypothyroidism and central nervous system disease. (1224969)
1975
44
Hyponatremia and central nervous system disease. (4154911)
1974
45
Requirement for theta-bearing cells in lymphocytic choriomeningitis virus-induced central nervous system disease. (4561841)
1972
46
Autokinesis and central nervous system disease. (5131768)
1971
47
Vaccination with measles and central nervous system disease. (5688849)
1968
48
Response to dexamethasone suppression in central nervous system disease. (5904545)
1966
49
WILSON'S DISEASE, AN INBORN ERROR OF METABOLISM AND A MODEL OF DEGENERATIVE CENTRAL NERVOUS SYSTEM DISEASE. (14156393)
1964
50
DEMYELINATING CENTRAL NERVOUS SYSTEM DISEASE, MACULAR ATROPHY AND ACANTHOCYTOSIS (BASSEN-KORNZWEIG SYNDROME). (14237436)
1964

Variations for Nervous System Disease

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Expression for genes affiliated with Nervous System Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Nervous System Disease

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Pathways for genes affiliated with Nervous System Disease

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Compounds for genes affiliated with Nervous System Disease

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Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB
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Compounds related to Nervous System Disease according to GeneCards/GeneDecks:

(show all 12)
idCompoundScoreTop Affiliating Genes
1oleic acid45 29 24 1112.4GC, MOG
2fmlp459.1GC, CXCR3
3sialic acid459.0CD46, GC
4heparan sulfate45 2410.0GC, CXCR3
5phosphatidylinositol459.0CD46, CXCR3, CHRM1
6endotoxin458.8GC, CXCR3
7glutamate458.7PICK1, CHRM1, GC
8nitric oxide45 24 1110.7CD46, MOG, CXCR3, CHRM1
9tyrosine458.5PICK1, CHRM1, CXCR3, CD46
10lipid458.5PICK1, CHRM1, MOG, GC
11serine457.8PICK1, CXCR3, MOG, GC, CD46
12calcium45 51 24 1110.4CD46, GC, MOG, CXCR3, CHRM1, PICK1

GO Terms for genes affiliated with Nervous System Disease

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16Gene Ontology
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Cellular components related to Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic membraneGO:0452119.5CHRM1, PICK1
2postsynaptic densityGO:0140699.4PICK1, CHRM1
3integral component of plasma membraneGO:0058878.6CD46, CXCR3, CHRM1
4plasma membraneGO:0058867.9CD46, MOG, CXCR3, CHRM1, PICK1

Biological processes related to Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein kinase C-activating G-protein coupled receptor signaling pathwayGO:0072059.5CHRM1, PICK1

Molecular functions related to Nervous System Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor activityGO:0048729.3CD46, CXCR3

Products for genes affiliated with Nervous System Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Nervous System Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet