MCID: NRL008
MIFTS: 26

Neural Crest Tumor

Categories: Rare diseases

Aliases & Classifications for Neural Crest Tumor

MalaCards integrated aliases for Neural Crest Tumor:

Name: Neural Crest Tumor 49 69
Neural Crest-Derived Tumors 49

Classifications:



External Ids:

UMLS 69 C2931189

Summaries for Neural Crest Tumor

MalaCards based summary : Neural Crest Tumor, also known as neural crest-derived tumors, is related to paragangliomas 1 and paragangliomas 5. An important gene associated with Neural Crest Tumor is SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Carbon metabolism. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Neural Crest Tumor

Diseases related to Neural Crest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 paragangliomas 1 30.1 ENSG00000255292 SDHB SDHC SDHD
2 paragangliomas 5 11.1
3 paragangliomas 4 11.1
4 ependymoblastoma 11.1
5 paragangliomas 2 11.1
6 paragangliomas 3 11.1
7 seminal vesicle tumor 10.0 SDHA SDHB
8 beckwith-wiedemann syndrome 9.9
9 neuroblastoma 9.9
10 body mass index quantitative trait locus 14 9.8
11 ataxia-oculomotor apraxia 3 9.8
12 body mass index quantitative trait locus 18 9.8
13 diarrhea 9.8
14 body mass index quantitative trait locus 11 9.8
15 ataxia and polyneuropathy, adult-onset 9.8
16 body mass index quantitative trait locus 9 9.8
17 body mass index quantitative trait locus 8 9.8
18 aceruloplasminemia 9.8
19 body mass index quantitative trait locus 7 9.8
20 body mass index quantitative trait locus 12 9.8
21 cowden syndrome 3 9.7 ENSG00000255292 SDHD
22 quadriplegia 9.7 SDHA SDHD
23 glomus tumor 9.7 SDHB SDHD
24 cerebellopontine angle tumor 9.7 ENSG00000255292 SDHD
25 multiple endocrine neoplasia 9.7 SDHB SDHC
26 multiple endocrine neoplasia, type iia 9.6 SDHB SDHD
27 kearns-sayre syndrome 9.4 ENSG00000255292 SDHA SDHD
28 multiple endocrine neoplasia, type i 9.4 SDHB SDHD
29 chondroma 9.4 SDHB SDHC SDHD
30 sporadic pheochromocytoma 9.3 SDHB SDHC SDHD
31 von hippel-lindau syndrome 9.3 SDHB SDHC SDHD
32 cowden disease 9.3 SDHB SDHC SDHD
33 neurofibromatosis, type iv, of riccardi 9.3 SDHB SDHC SDHD
34 carney triad 9.1 SDHA SDHB SDHC SDHD
35 leigh syndrome 9.1 ENSG00000255292 SDHA SDHB SDHD
36 adrenal medulla cancer 9.1 SDHAF2 SDHB SDHC SDHD
37 extra-adrenal pheochromocytoma 9.1 SDHAF2 SDHB SDHC SDHD
38 gastrointestinal stromal tumor 9.0 SDHA SDHB SDHC SDHD
39 phaeochromocytoma 9.0 SDHAF2 SDHB SDHC SDHD
40 paraganglioma and gastric stromal sarcoma 9.0 ENSG00000255292 SDHB SDHC SDHD
41 lymphatic system disease 9.0 ENSG00000255292 SDHB SDHC SDHD
42 endocrine gland cancer 9.0 ENSG00000255292 SDHB SDHC SDHD
43 persistent generalized lymphadenopathy 8.8 SDHA SDHAF2 SDHB SDHC SDHD
44 hereditary paraganglioma-pheochromocytoma syndromes 8.8 SDHA SDHAF2 SDHB SDHC SDHD
45 lymph node disease 8.8 SDHA SDHAF2 SDHB SDHC SDHD
46 paraganglioma 8.8 SDHA SDHAF2 SDHB SDHC SDHD
47 pheochromocytoma 8.7 ENSG00000255292 SDHA SDHB SDHC SDHD
48 mitochondrial complex ii deficiency 8.4 ENSG00000255292 SDHA SDHAF2 SDHB SDHC SDHD

Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to Neural Crest Tumor

Symptoms & Phenotypes for Neural Crest Tumor

GenomeRNAi Phenotypes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.17 SDHC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.17 SDHC SDHD
3 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.17 SDHC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.17 SDHC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.17 SDHC SDHD

Drugs & Therapeutics for Neural Crest Tumor

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 I-123-MIBG for Imaging of Neuroblastoma and Pheochromocytoma Completed NCT00590096
2 Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions Recruiting NCT03160274
3 International Congenital Central Hypoventilation Syndrome (CCHS) Registry Recruiting NCT03088020

Search NIH Clinical Center for Neural Crest Tumor

Genetic Tests for Neural Crest Tumor

Anatomical Context for Neural Crest Tumor

Publications for Neural Crest Tumor

Articles related to Neural Crest Tumor:

(show all 11)
# Title Authors Year
1
Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. ( 23474632 )
2013
2
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. ( 23186956 )
2013
3
Thoracic neural crest tumors in Beckwith-Wiedemann syndrome. ( 14515390 )
2003
4
Neural-crest tumor presenting with chronic diarrhea: a report of three cases. ( 12632821 )
2002
5
Vanilmandelic acid and homovanillic acid levels in patients with neural crest tumor: 24-hour urine collection versus random sample. ( 9185210 )
1997
6
Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus). ( 8578645 )
1995
7
Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. ( 2068150 )
1991
8
Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases. ( 2748231 )
1989
9
Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model. ( 7105037 )
1982
10
Cerebellar ataxia, opsoclonus, and occult neural crest tumor. Abdominal computerized tomography in diagnosis. ( 7435465 )
1980
11
Convulsions with an occult neural-crest tumor. ( 460316 )
1979

Variations for Neural Crest Tumor

Expression for Neural Crest Tumor

Search GEO for disease gene expression data for Neural Crest Tumor.

Pathways for Neural Crest Tumor

GO Terms for Neural Crest Tumor

Cellular components related to Neural Crest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.63 ENSG00000255292 SDHA SDHAF2 SDHB SDHC SDHD
2 mitochondrial inner membrane GO:0005743 9.35 ENSG00000255292 SDHA SDHB SDHC SDHD
3 mitochondrial envelope GO:0005740 9.32 ENSG00000255292 SDHD
4 respiratory chain complex II GO:0045273 9.26 SDHB SDHC
5 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 9.02 ENSG00000255292 SDHA SDHB SDHC SDHD

Biological processes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.55 ENSG00000255292 SDHA SDHB SDHC SDHD
2 electron transport chain GO:0022900 9.43 SDHA SDHB SDHC
3 tricarboxylic acid cycle GO:0006099 9.43 ENSG00000255292 SDHA SDHAF2 SDHB SDHC SDHD
4 aerobic respiration GO:0009060 9.4 SDHB SDHC
5 respiratory electron transport chain GO:0022904 9.37 SDHA SDHB
6 succinate metabolic process GO:0006105 9.32 SDHA SDHB
7 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.02 ENSG00000255292 SDHA SDHAF2 SDHC SDHD

Molecular functions related to Neural Crest Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.5 ENSG00000255292 SDHC SDHD
2 ubiquinone binding GO:0048039 9.43 ENSG00000255292 SDHB SDHD
3 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.37 SDHA SDHC
4 electron transfer activity GO:0009055 9.35 ENSG00000255292 SDHA SDHB SDHC SDHD
5 succinate dehydrogenase activity GO:0000104 9.33 SDHA SDHC SDHD
6 succinate dehydrogenase (ubiquinone) activity GO:0008177 8.92 ENSG00000255292 SDHA SDHB SDHD

Sources for Neural Crest Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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