Neural Crest Tumor malady

MalaCards: Neural Crest Tumor, also known as neural crest-derived tumors, is related to cowden-like syndrome and seminal vesicle tumor. An important gene associated with Neural Crest Tumor is SDHAF2 (succinate dehydrogenase complex assembly factor 2), and among its related pathways are Citric acid cycle (TCA cycle) and Citrate cycle (TCA cycle). The compounds thenoyltrifluoroacetone and nad+ have been mentioned in the context of this disorder.

neural crest tumor 30 43 neural crest-derived tumors 30

Diseases related to neural crest tumor by text searches and GeneDecks gene sharing:

(show all 42)

id	Related Disease	Score	Top Affiliating Genes
1	cowden-like syndrome	12.8	SDHB, SDHD
2	seminal vesicle tumor	12.7	SDHA, SDHB
3	neuroendocrine tumor	12.7	NPY, SDHD
4	leigh disease	12.6	SDHA, SDHB
5	cranial nerve palsy	12.5	SDHC, SDHD
6	vascular dementia	12.5	NPY, SDHB
7	leukodystrophy	12.4	SDHB, SDHA
8	glomus tumor	12.4	SDHAF2, SDHB, SDHD
9	nasopharynx carcinoma	12.3	SDHD, SDHC
10	huntington's disease	12.2	SDHB, NPY
11	insulinoma	12.2	SDHB, SDHD, NPY
12	paraganglioma and gastric stromal sarcoma	12.0	SDHD, SDHC, SDHB
13	carotid body tumor	12.0	SDHD, SDHC, SDHB
14	familial medullary thyroid carcinoma	12.0	SDHB, SDHC, SDHD
15	familial renal cell carcinoma	12.0	SDHD, SDHC, SDHB
16	multiple endocrine neoplasia type 2a	12.0	SDHB, SDHC, SDHD
17	wermer syndrome	12.0	SDHB, SDHC, SDHD
18	adrenal adenoma	12.0	SDHB, SDHC, SDHD
19	adrenocortical tumor	11.9	SDHB, SDHC, SDHD
20	neurofibromatosis	11.9	SDHD, SDHC, SDHB
21	hyperparathyroidism	11.8	SDHB, SDHC, SDHD
22	thyroid cancer	11.8	SDHB, SDHC, SDHD
23	acute leukemia	11.8	SDHB, SDHC, SDHD
24	renal cell carcinoma	11.7	SDHB, SDHC, NPY
25	hereditary paraganglioma-pheochromocytoma syndromes	11.6	SDHD, SDHC, SDHB, SDHAF2
26	hemangioma	11.6	SDHD, SDHC, SDHB, SDHAF2
27	mitochondrial complex ii deficiency	11.5	SDHA, SDHB, SDHC, SDHD
28	carney triad	11.5	SDHD, SDHC, SDHB, SDHA
29	chondroma	11.5	SDHD, SDHC, SDHB, SDHA
30	multiple endocrine neoplasia	11.5	NPY, SDHD, SDHC, SDHB
31	gastrointestinal stromal tumor	11.4	SDHD, SDHC, SDHB, SDHA
32	thyroid carcinoma	11.3	SDHD, SDHC, SDHB
33	hypoxia	11.1	NPY, SDHD, SDHC, SDHB
34	von hippel-lindau disease	11.0	SDHA, SDHB, SDHC, SDHD, NPY
35	parkinson's disease	10.9	NPY, SDHD, SDHC, SDHB, SDHA
36	sarcoma	10.9	NPY, SDHD, SDHC, SDHB, SDHA
37	thyroiditis	10.8	NPY, SDHD, SDHC, SDHB, SDHA
38	alzheimer's disease	10.8	NPY, SDHD, SDHC, SDHB, SDHA
39	paraganglioma	10.6	NPY, SDHD, SDHC, SDHB, SDHAF2, SDHA
40	pheochromocytoma	10.5	NPY, SDHD, SDHC, SDHB, SDHAF2, SDHA
41	breast cancer	10.5	SDHA, SDHB, SDHC, SDHD, NPY
42	ependymoblastoma	7.1

Approved drugs:

Drug clinical trials:

Articles related to neural crest tumor:

id	Title	Authors	Year	Affiliating Genes
1	Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. (2068150)	Kogner P.... Theodorsson E.	1991	NPY

Genes related to neural crest tumor according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	SDHAF2	succinate dehydrogenase complex assembly factor 2	11.0
2	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	11.0
3	SDHA	succinate dehydrogenase complex, subunit A, flavoprotein (Fp)	11.0
4	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.0
5	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	11.0
6	NPY	neuropeptide Y	11.0	Publications

Pathways related to neural crest tumor according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Citric acid cycle (TCA cycle)38	8.2	SDHD, SDHC, SDHB, SDHA
2	Citrate cycle (TCA cycle)20	8.2	SDHC, SDHB, SDHA, SDHD
3	Parkinsons disease20	8.1	SDHA, SDHD, SDHB, SDHC
4	Oxidative phosphorylation20	8.1	SDHB, SDHD, SDHC, SDHA
5	Metabolic pathways20	8.1	SDHD, SDHC, SDHB, SDHA
6	Alzheimers disease20	8.0	SDHA, SDHD, SDHB, SDHC
7	Huntingtons disease20	7.8	SDHD, SDHC, SDHB, SDHA

Compounds related to neural crest tumor according to GeneDecks:

(show all 13)

id	Compound	Score	Top Affiliating Genes
1	thenoyltrifluoroacetone32 9 9	11.4	SDHB, SDHA
2	nad+32	9.3	SDHB, SDHA
3	mibg32	9.3	SDHB, SDHD
4	catecholamine32	8.9	SDHB, SDHD, NPY
5	fumarate32 9 9	10.7	SDHC, SDHB, SDHD
6	UBIQUINONE-19 9	9.3	SDHD, SDHC, SDHB, SDHA
7	2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol9 9	9.3	SDHA, SDHB, SDHD, SDHC
8	iron-sulfur32	8.3	SDHC, SDHD, SDHB, SDHA
9	Succinic acid9 18 9	10.3	SDHC, SDHB, SDHD, SDHA
10	ubiquinone32	8.3	SDHD, SDHB, SDHA, SDHC
11	succinate32	8.2	SDHB, SDHA, SDHD, SDHC
12	iron32 18	9.2	SDHD, SDHC, SDHA, SDHB
13	oxygen32 18	8.8	SDHD, SDHC, SDHB, SDHA

Cellular components related to neural crest tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial respiratory chain complex II	GO:005749	8.0	SDHD, SDHC, SDHB, SDHA
2	mitochondrial inner membrane	GO:005743	7.8	SDHD, SDHC, SDHB, SDHA
3	mitochondrion	GO:005739	7.6	SDHD, SDHC, SDHB, SDHAF2, SDHA

Biological processes related to neural crest tumor according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	mitochondrial electron transport, succinate to ubiquinone	GO:006121	9.7	SDHD, SDHAF2
2	succinate metabolic process	GO:006105	9.3	SDHB, SDHA
3	oxidation-reduction process	GO:055114	9.1	SDHA, SDHC
4	aerobic respiration	GO:009060	8.9	SDHB, SDHC
5	tricarboxylic acid cycle	GO:006099	8.2	SDHA, SDHB, SDHC, SDHD
6	respiratory electron transport chain	GO:022904	8.2	SDHD, SDHC, SDHB, SDHA
7	small molecule metabolic process	GO:044281	7.8	SDHD, SDHC, SDHB, SDHA

Molecular functions related to neural crest tumor according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	succinate dehydrogenase (ubiquinone) activity	GO:008177	9.2	SDHA, SDHB
2	ubiquinone binding	GO:048039	9.1	SDHB, SDHD
3	succinate dehydrogenase activity	GO:000104	8.7	SDHA, SDHC, SDHD
4	electron carrier activity	GO:009055	8.6	SDHC, SDHD, SDHB