MCID: NRL008
MIFTS: 29

Neural Crest Tumor malady

Rare diseases, Cancer diseases categories
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Summaries for Neural Crest Tumor

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MalaCards based summary: Neural Crest Tumor, also known as neural crest-derived tumors, is related to neuroblastoma and paragangliomas 5. An important gene associated with Neural Crest Tumor is SDHAF2 (succinate dehydrogenase complex assembly factor 2), and among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The compounds thenoyltrifluoroacetone and Ubiquinol 8 have been mentioned in the context of this disorder.

Aliases & Classifications for Neural Crest Tumor

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Neural Crest Tumor, Aliases & Descriptions:

Name: Neural Crest Tumor 42 62
 
Neural Crest-Derived Tumors 42 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Neural Crest Tumor

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Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to neural crest tumor

Symptoms for Neural Crest Tumor

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Drugs & Therapeutics for Neural Crest Tumor

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Drug clinical trials:

Search ClinicalTrials for Neural Crest Tumor

Search NIH Clinical Center for Neural Crest Tumor

Genetic Tests for Neural Crest Tumor

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Anatomical Context for Neural Crest Tumor

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Animal Models for Neural Crest Tumor or affiliated genes

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Publications for Neural Crest Tumor

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Articles related to Neural Crest Tumor:

(show all 11)
idTitleAuthorsYear
1
Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. (23474632)
2013
2
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. (23186956)
2013
3
Thoracic neural crest tumors in Beckwith-Wiedemann syndrome. (14515390)
2003
4
Neural-crest tumor presenting with chronic diarrhea: a report of three cases. (12632821)
2002
5
Vanilmandelic acid and homovanillic acid levels in patients with neural crest tumor: 24-hour urine collection versus random sample. (9185210)
1997
6
Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus). (8578645)
1995
7
Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. (2068150)
1991
8
Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases. (2748231)
1989
9
Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model. (7105037)
1982
10
Cerebellar ataxia, opsoclonus, and occult neural crest tumor. Abdominal computerized tomography in diagnosis. (7435465)
1980
11
Convulsions with an occult neural-crest tumor. (460316)
1979

Variations for Neural Crest Tumor

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Expression for genes affiliated with Neural Crest Tumor

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Expression patterns in normal tissues for genes affiliated with Neural Crest Tumor

Search GEO for disease gene expression data for Neural Crest Tumor.

Pathways for genes affiliated with Neural Crest Tumor

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Pathways related to Neural Crest Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.1SDHA, SDHC, SDHD, SDHB
2
Show member pathways
8.1SDHB, SDHD, SDHC, SDHA
3
Show member pathways
Alzheimers Disease37
8.1SDHB, SDHD, SDHC, SDHA
4
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
8.1SDHB, SDHD, SDHC, SDHA
5
Show member pathways
TCA cycle37
pyruvate decarboxylation to acetyl CoA37
NAD phosphorylation and dephosphorylation37
TCA Cycle37
conversion of glucose to acetyl CoA and entry into the TCA cycle37
8.1SDHA, SDHC, SDHD, SDHB

Compounds for genes affiliated with Neural Crest Tumor

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Neural Crest Tumor according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1thenoyltrifluoroacetone44 1110.4SDHA, SDHB
2Ubiquinol 8249.4SDHA, SDHB
3mibg449.4SDHD, SDHB
4heme28 24 1111.2SDHC, SDHD
5nad+449.0SDHA, SDHB
6catecholamine449.0SDHB, SDHD, NPY
7fumarate44 119.8SDHC, SDHD, SDHB
8Fumaric acid248.4SDHA, SDHC, SDHD, SDHB
9succinic acid28 24 1110.4SDHB, SDHD, SDHC, SDHA
10iron-sulfur448.4SDHB, SDHD, SDHC, SDHA
11ubiquinone448.4SDHB, SDHD, SDHC, SDHA
12Sulfide248.3SDHB, SDHD, SDHC, SDHA
13QH2248.3SDHA, SDHC, SDHD, SDHB
14Ubiquinone Q2248.3SDHB, SDHD, SDHC, SDHA
15Ubiquinone Q1248.3SDHA, SDHC, SDHD, SDHB
16succinate448.3SDHB, SDHD, SDHC, SDHA
17FAD248.3SDHB, SDHD, SDHC, SDHA
18iron44 249.2SDHA, SDHC, SDHD, SDHB
19oxygen44 249.0SDHB, SDHD, SDHC, SDHA

GO Terms for genes affiliated with Neural Crest Tumor

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Cellular components related to Neural Crest Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:0057498.0SDHB, SDHD, SDHC, SDHA
2mitochondrial inner membraneGO:0057437.8SDHB, SDHD, SDHC, SDHA
3mitochondrionGO:0057397.6SDHB, SDHD, SDHAF2, SDHC, SDHA

Biological processes related to Neural Crest Tumor according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1succinate metabolic processGO:0061059.3SDHA, SDHB
2oxidation-reduction processGO:0551149.1SDHA, SDHC
3aerobic respirationGO:0090608.9SDHC, SDHB
4tricarboxylic acid cycleGO:0060998.2SDHA, SDHC, SDHD, SDHB
5respiratory electron transport chainGO:0229048.2SDHB, SDHD, SDHC, SDHA
6cellular metabolic processGO:0442378.1SDHB, SDHD, SDHC, SDHA
7small molecule metabolic processGO:0442817.8SDHB, SDHD, SDHC, SDHA

Molecular functions related to Neural Crest Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:0081779.3SDHA, SDHB
2heme bindingGO:0200379.2SDHC, SDHD
3ubiquinone bindingGO:0480399.1SDHD, SDHB
4succinate dehydrogenase activityGO:0001048.7SDHA, SDHC, SDHD
5electron carrier activityGO:0090558.5SDHB, SDHD, SDHC

Products for genes affiliated with Neural Crest Tumor

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  • Antibodies
  • Proteins
  • Lysates

Sources for Neural Crest Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet