MCID: NRL008
MIFTS: 23

Neural Crest Tumor malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Neural Crest Tumor

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Aliases & Descriptions for Neural Crest Tumor:

Name: Neural Crest Tumor 45 65
 
Neural Crest-Derived Tumors 45

Classifications:



External Ids:

UMLS65 C2931189

Summaries for Neural Crest Tumor

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MalaCards based summary: Neural Crest Tumor, also known as neural crest-derived tumors, is related to paragangliomas 5 and paragangliomas 4. An important gene associated with Neural Crest Tumor is SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Alzheimers disease. Affiliated tissues include thyroid and endothelial.

Related Diseases for Neural Crest Tumor

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Diseases related to Neural Crest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 52)
idRelated DiseaseScoreTop Affiliating Genes
1paragangliomas 530.8SDHA, SDHB
2paragangliomas 430.8SDHA, SDHB
3paragangliomas 310.5
4paragangliomas 210.5
5paragangliomas 1, with or without deafness10.5
6acute pancreatitis10.2
7pancreatitis10.2
8encephalitis10.2
9cowden syndrome 210.1SDHA, SDHB
10rheumatoid arthritis10.1
11arthritis10.1
12end stage renal failure10.1
13hepatitis10.1
14viral hepatitis10.1
15tic disorder10.1
16hemoglobin e disease10.1
17albinism, oculocutaneous, type iv10.0SDHA, SDHB
18acute salpingo-oophoritis10.0SDHA, SDHD
19senile entropion10.0SDHA, SDHD
20cataract hutterite type10.0SDHB, SDHD
21male reproductive organ cancer10.0SDHA, SDHB
22gallbladder adenoma10.0SDHB, SDHD
23cataract 4, multiple types10.0SDHB, SDHD
24epidermal appendage tumor10.0SDHB, SDHD
25multiple endocrine neoplasia iib9.9SDHB, SDHD
26peptic ulcer disease9.8SDHB, SDHD
27immunodeficiency, common variable, 59.8SDHB, SDHD
28alcoholic cardiomyopathy9.7SDHA, SDHD
29myopathy with deficiency of iron-sulfur cluster assembly enzyme9.6SDHC, SDHD
30leigh syndrome9.6SDHA, SDHB, SDHD
31familial stomach cancer9.5SDHB, SDHC, SDHD
32carcinoid tumors, intestinal9.5SDHB, SDHC, SDHD
33adenomyoma9.5SDHB, SDHC, SDHD
34sporadic pheochromocytoma/secreting paraganglioma9.5SDHB, SDHC, SDHD
35neurofibromatosis, familial spinal9.5SDHB, SDHC, SDHD
36von hippel-lindau syndrome9.5SDHB, SDHC, SDHD
37cerebellar liponeurocytoma9.5SDHB, SDHC, SDHD
38steroid inherited metabolic disorder9.5SDHB, SDHC, SDHD
39decubitus ulcer9.5SDHB, SDHC, SDHD
40paraganglioma and gastric stromal sarcoma9.3SDHA, SDHB, SDHC, SDHD
41carnitine palmitoyltransferase i deficiency , muscle9.3SDHA, SDHB, SDHC, SDHD
42glycogen storage disease ib9.3SDHA, SDHB, SDHC, SDHD
43gastrointestinal stromal tumor9.3SDHA, SDHB, SDHC, SDHD
44pheochromocytoma9.2SDHA, SDHB, SDHC, SDHD
45mononeuritis of upper limb and mononeuritis multiplex9.2SDHAF2, SDHB, SDHC, SDHD
46retroperitoneal neuroblastoma9.2SDHAF2, SDHB, SDHC, SDHD
47spastic ataxia 19.2SDHAF2, SDHB, SDHC, SDHD
48neuroaxonal dystrophy renal tubular acidosis9.0SDHA, SDHAF2, SDHB, SDHC, SDHD
49oral hairy leukoplakia9.0SDHA, SDHAF2, SDHB, SDHC, SDHD
50constant exophthalmos9.0SDHA, SDHAF2, SDHB, SDHC, SDHD

Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to neural crest tumor

Symptoms for Neural Crest Tumor

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Drugs & Therapeutics for Neural Crest Tumor

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Drugs for Neural Crest Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SomatostatinPhase 215351110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
2Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 29988
3HormonesPhase 211748
4Hormone AntagonistsPhase 210002

Interventional clinical trials:

idNameStatusNCT IDPhase
1177Lutetium-DOTA-Octreotate Therapy in Somatostatin Receptor-Expressing Neuroendocrine NeoplasmsActive, not recruitingNCT01237457Phase 2
2I-123-MIBG for Imaging of Neuroblastoma and PheochromocytomaCompletedNCT00590096
3Study of Molecular Pathways in Medullary Thyroid Carcinoma and Correlation of Molecular Data With Clinical Behavior of the MTC in Individuals PatientsCompletedNCT01424878
4The Role of IMP3 Expression in Patients With NeuroblastomaCompletedNCT01121419

Search NIH Clinical Center for Neural Crest Tumor

Genetic Tests for Neural Crest Tumor

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Anatomical Context for Neural Crest Tumor

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MalaCards organs/tissues related to Neural Crest Tumor:

33
Thyroid, Endothelial

Animal Models for Neural Crest Tumor or affiliated genes

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MGI Mouse Phenotypes related to Neural Crest Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Neural Crest Tumor

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Articles related to Neural Crest Tumor:

(show all 11)
idTitleAuthorsYear
1
Reconciling the clinical practice guidelines on Bell's palsy from the AAO-HNSF and the AAN. (24789656)
2014
2
Five most common prognostically important fusion oncogenes are detected in the majority of Pakistani pediatric acute lymphoblastic leukemia patients and are strongly associated with disease biology and treatment outcome. (23317202)
2012
3
AluYb8 insertion in the MUTYH gene is related to increased 8-OHdG in genomic DNA and could be a risk factor for type 2 diabetes in a Chinese population. (21112374)
2011
4
Determination of apparent calcium affinity for endogenously expressed human sarco(endo)plasmic reticulum calcium-ATPase isoform SERCA3. (19225163)
2009
5
Fatty acids differentially influence phosphatidylinositol 3-kinase signal transduction in endothelial cells: impact on adhesion and apoptosis. (17950294)
2008
6
The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain. (16237091)
2005
7
Atypical effect of salts on the thermodynamic stability of human prion protein. (12676939)
2003
8
Mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites. (11800564)
2001
9
Serum nm23-H1 protein as a prognostic factor in aggressive non-Hodgkin lymphoma. (11222361)
2001
10
Reduction of bacteriuria and pyuria using cranberry juice. (8057505)
1994
11
Acute and long-term effects of acebutolol on systemic and renal hemodynamics, body fluid volumes, catecholamines, active renin, aldosterone, and lymphocyte beta-adrenoceptor density. (2453744)
1988

Variations for Neural Crest Tumor

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Expression for genes affiliated with Neural Crest Tumor

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Search GEO for disease gene expression data for Neural Crest Tumor.

Pathways for genes affiliated with Neural Crest Tumor

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GO Terms for genes affiliated with Neural Crest Tumor

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Biological processes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1succinate metabolic processGO:00061059.4SDHA, SDHB

Molecular functions related to Neural Crest Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:00081779.9SDHA, SDHB
2oxidoreductase activity, acting on the CH-CH group of donorsGO:00166279.5SDHA, SDHC
3oxidoreductase activityGO:00164919.4SDHA, SDHB
4electron carrier activityGO:00090559.2SDHB, SDHD

Sources for Neural Crest Tumor

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet