MCID: NRL008
MIFTS: 26

Neural Crest Tumor malady

Cancer category

Summaries for Neural Crest Tumor

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33MalaCards
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MalaCards: Neural Crest Tumor, also known as neural crest-derived tumors, is related to n syndrome and beckwith-wiedemann syndrome. An important gene associated with Neural Crest Tumor is SDHAF2 (succinate dehydrogenase complex assembly factor 2), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Carbon metabolism. The compounds thenoyltrifluoroacetone and nad+ have been mentioned in the context of this disorder. Affiliated tissues include endothelial.

Aliases & Classifications for Neural Crest Tumor

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43NIH Rare Diseases, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

neural crest tumor 43 61
neural crest-derived tumors 43


Related Diseases for Neural Crest Tumor

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to neural crest tumor

Clinical Features for Neural Crest Tumor

Drugs & Therapeutics for Neural Crest Tumor

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neural Crest Tumor

Anatomical Context for Neural Crest Tumor

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33MalaCards
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MalaCards organs/tissues related to Neural Crest Tumor:

33
Endothelial

Animal Models for Neural Crest Tumor or affiliated genes

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28inGenious Targeting Laboratory
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Publications for Neural Crest Tumor

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51PubMed
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Articles related to Neural Crest Tumor:

(show all 28)
idTitleAuthorsYear
1
Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. (23474632)
2013
2
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. (23186956)
2013
3
Epigenetic modifiers as anticancer drugs: effectiveness of valproic acid in neural crest-derived tumor cells. (20332466)
2010
4
Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formation. (19458200)
2009
5
Enteric neural crest differentiation in ganglioneuromas implicates Hedgehog signaling in peripheral neuroblastic tumor pathogenesis. (19834598)
2009
6
Actin expression in neural crest cell-derived tumors including schwannomas, malignant peripheral nerve sheath tumors, neurofibromas and melanocytic tumors. (19154261)
2009
7
HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells. (19805377)
2009
8
Neuropeptide Y in neural crest-derived tumors: effect on growth and vascularization. (16513255)
2007
9
EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors. (15930281)
2005
10
Temporally regulated neural crest transcription factors distinguish neuroectodermal tumors of varying malignancy and differentiation. (16036108)
2005
11
DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets. (15548687)
2004
12
Expression of PAX 3 alternatively spliced transcripts and identification of two new isoforms in human tumors of neural crest origin. (14639621)
2004
13
Thoracic neural crest tumors in Beckwith-Wiedemann syndrome. (14515390)
2003
14
Neural-crest tumor presenting with chronic diarrhea: a report of three cases. (12632821)
2002
15
Vanilmandelic acid and homovanillic acid levels in patients with neural crest tumor: 24-hour urine collection versus random sample. (9185210)
1997
16
Expression of the RET proto-oncogene in normal human tissues, pheochromocytomas, and other tumors of neural crest origin. (8912182)
1996
17
Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus). (8578645)
1995
18
Expression of integrin and CD44 adhesion molecules on neuroblastoma: the relation to tumor aggressiveness and embryonic neural-crest differentiation. (7544774)
1994-1995
19
Evidence for further heterogeneity of the receptors for neuropeptide-Y and peptide-YY in tumor cell lines derived from neural crest. (1330489)
1992
20
Expression and ligand-binding function of the integrin alpha 4 beta 1 (VLA-4) on neural-crest-derived tumor cell lines. (1535575)
1992
21
Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. (2068150)
1991
22
Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases. (2748231)
1989
23
Distinct isozyme patterns of cyclic nucleotide phosphodiesterase in human neuroblastoma and ganglioneuroma; a possible marker of differentiation of neural crest-derived tumors and Schwann cells. (3007415)
1986
24
Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model. (7105037)
1982
25
Cerebellar ataxia, opsoclonus, and occult neural crest tumor. Abdominal computerized tomography in diagnosis. (7435465)
1980
26
Convulsions with an occult neural-crest tumor. (460316)
1979
27
Ectomesenchymoma. A malignant tumor of migratory neural crest (ectomesenchyme) remnants showing ganglionic, schwannian, melanocytic and rhabdomyoblastic differentiation. (872048)
1977
28
Pigmented ganglioneuroblastoma: relation of melanin and lipofuscin to schwannomas and other tumors of neural crest origin. (180265)
1976

Genetic Variations for Neural Crest Tumor

Expression for genes affiliated with Neural Crest Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neural Crest Tumor

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Pathways for genes affiliated with Neural Crest Tumor

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54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore
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Compounds for genes affiliated with Neural Crest Tumor

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45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB
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Compounds related to Neural Crest Tumor according to GeneCards/GeneDecks:

(show all 13)
idCompoundScoreTop Affiliating Genes
1thenoyltrifluoroacetone45 1110.2SDHA, SDHB
2nad+459.1SDHA, SDHB
3mibg459.0SDHB, SDHD
4catecholamine458.7NPY, SDHD, SDHB
5fumarate45 119.7SDHC, SDHB, SDHD
6UBIQUINONE-1118.3SDHA, SDHC, SDHB, SDHD
72-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol118.2SDHD, SDHB, SDHC, SDHA
8succinic acid29 11 2410.2SDHD, SDHB, SDHC, SDHA
9iron-sulfur458.2SDHD, SDHB, SDHC, SDHA
10ubiquinone458.2SDHD, SDHB, SDHC, SDHA
11succinate458.2SDHD, SDHB, SDHC, SDHA
12iron45 249.1SDHD, SDHB, SDHC, SDHA
13oxygen45 248.7SDHA, SDHC, SDHB, SDHD

GO Terms for genes affiliated with Neural Crest Tumor

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16Gene Ontology
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Cellular components related to Neural Crest Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:0057497.9SDHD, SDHB, SDHC, SDHA
2mitochondrial inner membraneGO:0057437.7SDHD, SDHB, SDHC, SDHA
3mitochondrionGO:0057397.6SDHD, SDHAF2, SDHB, SDHC, SDHA

Biological processes related to Neural Crest Tumor according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1oxidation-reduction processGO:0551149.3SDHA, SDHC
2succinate metabolic processGO:0061059.1SDHA, SDHB
3aerobic respirationGO:0090608.9SDHC, SDHB
4tricarboxylic acid cycleGO:0060998.1SDHA, SDHC, SDHB, SDHD
5respiratory electron transport chainGO:0229048.1SDHD, SDHB, SDHC, SDHA
6cellular metabolic processGO:0442378.1SDHD, SDHB, SDHC, SDHA
7small molecule metabolic processGO:0442817.7SDHD, SDHB, SDHC, SDHA

Molecular functions related to Neural Crest Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.3SDHC, SDHD
2succinate dehydrogenase (ubiquinone) activityGO:0081779.1SDHA, SDHB
3ubiquinone bindingGO:0480399.0SDHB, SDHD
4electron carrier activityGO:0090558.2SDHC, SDHB, SDHD

Products for genes affiliated with Neural Crest Tumor

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Sources for Neural Crest Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet