MCID: NRL008
MIFTS: 29

Neural Crest Tumor malady

Rare diseases, Cancer diseases categories
Download this MalaCard

Summaries for Neural Crest Tumor

About this section
Sources:
33MalaCards
See all sources

Fully expand this MalaCard
MalaCards: Neural Crest Tumor, also known as neural crest-derived tumors, is related to neuroblastoma and beckwith-wiedemann syndrome. An important gene associated with Neural Crest Tumor is SDHAF2 (succinate dehydrogenase complex assembly factor 2), and among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The compounds thenoyltrifluoroacetone and Ubiquinol 8 have been mentioned in the context of this disorder.

Aliases & Classifications for Neural Crest Tumor

About this section
Sources:
43NIH Rare Diseases, 62UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

neural crest tumor 43 62
neural crest-derived tumors 43


Related Diseases for Neural Crest Tumor

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to neural crest tumor

Symptoms for Neural Crest Tumor

About this section

Drugs & Therapeutics for Neural Crest Tumor

About this section
Sources:
42NIH Clinical Center, 6ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Neural Crest Tumor

Search NIH Clinical Center for Neural Crest Tumor

Genetic Tests for Neural Crest Tumor

About this section

Anatomical Context for Neural Crest Tumor

About this section

Animal Models for Neural Crest Tumor or affiliated genes

About this section

Publications for Neural Crest Tumor

About this section
Sources:
52PubMed
See all sources

Articles related to Neural Crest Tumor:

(show all 11)
idTitleAuthorsYear
1
Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. (23474632)
2013
2
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. (23186956)
2013
3
Thoracic neural crest tumors in Beckwith-Wiedemann syndrome. (14515390)
2003
4
Neural-crest tumor presenting with chronic diarrhea: a report of three cases. (12632821)
2002
5
Vanilmandelic acid and homovanillic acid levels in patients with neural crest tumor: 24-hour urine collection versus random sample. (9185210)
1997
6
Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus). (8578645)
1995
7
Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. (2068150)
1991
8
Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases. (2748231)
1989
9
Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model. (7105037)
1982
10
Cerebellar ataxia, opsoclonus, and occult neural crest tumor. Abdominal computerized tomography in diagnosis. (7435465)
1980
11
Convulsions with an occult neural-crest tumor. (460316)
1979

Variations for Neural Crest Tumor

About this section

Expression for genes affiliated with Neural Crest Tumor

About this section
Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Neural Crest Tumor

Search GEO for disease gene expression data for Neural Crest Tumor.

Pathways for genes affiliated with Neural Crest Tumor

About this section
Sources:
50PathCards, 55Reactome, 30KEGG, 38NCBI BioSystems Database, 51PharmGKB
See all sources

Pathways related to Neural Crest Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.1SDHA, SDHC, SDHD, SDHB
2
Show member pathways
8.1SDHB, SDHD, SDHC, SDHA
3
Show member pathways
Alzheimers Disease38
8.1SDHB, SDHD, SDHC, SDHA
4
Show member pathways
L-serine degradation38
pentose phosphate pathway (oxidative branch)38
formaldehyde oxidation II (glutathione-dependent)38
8.1SDHB, SDHD, SDHC, SDHA
5
Show member pathways
TCA cycle38
pyruvate decarboxylation to acetyl CoA38
NAD phosphorylation and dephosphorylation38
TCA Cycle38
conversion of glucose to acetyl CoA and entry into the TCA cycle38
8.1SDHA, SDHC, SDHD, SDHB

Compounds for genes affiliated with Neural Crest Tumor

About this section
Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR
See all sources

Compounds related to Neural Crest Tumor according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1thenoyltrifluoroacetone45 1110.4SDHA, SDHB
2Ubiquinol 8249.4SDHA, SDHB
3mibg459.4SDHD, SDHB
4heme29 24 1111.2SDHC, SDHD
5nad+459.0SDHA, SDHB
6catecholamine459.0SDHB, SDHD, NPY
7fumarate45 119.8SDHC, SDHD, SDHB
8Fumaric acid248.4SDHA, SDHC, SDHD, SDHB
9succinic acid29 24 1110.4SDHB, SDHD, SDHC, SDHA
10iron-sulfur458.4SDHB, SDHD, SDHC, SDHA
11ubiquinone458.4SDHB, SDHD, SDHC, SDHA
12Sulfide248.3SDHB, SDHD, SDHC, SDHA
13QH2248.3SDHA, SDHC, SDHD, SDHB
14Ubiquinone Q2248.3SDHB, SDHD, SDHC, SDHA
15Ubiquinone Q1248.3SDHA, SDHC, SDHD, SDHB
16succinate458.3SDHB, SDHD, SDHC, SDHA
17FAD248.3SDHB, SDHD, SDHC, SDHA
18iron45 249.2SDHA, SDHC, SDHD, SDHB
19oxygen45 249.0SDHB, SDHD, SDHC, SDHA

GO Terms for genes affiliated with Neural Crest Tumor

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Neural Crest Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:0057498.0SDHB, SDHD, SDHC, SDHA
2mitochondrial inner membraneGO:0057437.8SDHB, SDHD, SDHC, SDHA
3mitochondrionGO:0057397.6SDHB, SDHD, SDHAF2, SDHC, SDHA

Biological processes related to Neural Crest Tumor according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1succinate metabolic processGO:0061059.3SDHB, SDHA
2oxidation-reduction processGO:0551149.1SDHA, SDHC
3aerobic respirationGO:0090608.9SDHB, SDHC
4tricarboxylic acid cycleGO:0060998.2SDHA, SDHC, SDHD, SDHB
5respiratory electron transport chainGO:0229048.2SDHB, SDHD, SDHC, SDHA
6cellular metabolic processGO:0442378.1SDHB, SDHA, SDHC, SDHD
7small molecule metabolic processGO:0442817.8SDHA, SDHC, SDHD, SDHB

Molecular functions related to Neural Crest Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:0081779.3SDHA, SDHB
2heme bindingGO:0200379.2SDHC, SDHD
3ubiquinone bindingGO:0480399.1SDHD, SDHB
4succinate dehydrogenase activityGO:0001048.7SDHA, SDHC, SDHD
5electron carrier activityGO:0090558.5SDHB, SDHD, SDHC

Products for genes affiliated with Neural Crest Tumor

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neural Crest Tumor

About this section
4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet