MCID: NRL008
MIFTS: 25

Neural Crest Tumor malady

Categories: Rare diseases

Aliases & Classifications for Neural Crest Tumor

Aliases & Descriptions for Neural Crest Tumor:

Name: Neural Crest Tumor 50 69
Neural Crest-Derived Tumors 50

Classifications:



Summaries for Neural Crest Tumor

MalaCards based summary : Neural Crest Tumor, also known as neural crest-derived tumors, is related to paragangliomas 4 and paragangliomas 3. An important gene associated with Neural Crest Tumor is SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Carbon metabolism. The drugs Somatostatin and Hormone Antagonists have been mentioned in the context of this disorder. Related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Neural Crest Tumor

Diseases related to Neural Crest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
id Related Disease Score Top Affiliating Genes
1 paragangliomas 4 10.9
2 paragangliomas 3 10.9
3 paragangliomas 5 10.9
4 paragangliomas 2 10.9
5 paragangliomas 1, with or without deafness 10.9
6 acute salpingitis 10.1 SDHA SDHD
7 prolapse of female genital organ 10.0 SDHA SDHD
8 catastrophic antiphospholipid syndrome 10.0 SDHB SDHD
9 medullomyoblastoma 10.0 SDHA SDHB
10 acrocapitofemoral dysplasia 10.0 SDHB SDHD
11 bone ameloblastoma 10.0 SDHB SDHD
12 glomangioma 10.0 SDHB SDHD
13 central hypoventilation syndrome, congenital 9.9 SDHB SDHD
14 seborrheic dermatitis 9.9 SDHB SDHD
15 lumbar spinal canal and spinal cord meningioma 9.9 SDHB SDHD
16 neuroblastoma 9.9
17 beckwith-wiedemann syndrome 9.9
18 aneurysm 9.8 SDHB SDHC
19 leukemia, acute promyelocytic, somatic 9.8 SDHB SDHD
20 bjornstad syndrome 9.8 SDHA SDHB SDHD
21 paraganglioma and gastric stromal sarcoma 9.7 SDHB SDHC SDHD
22 glioma susceptibility 2 9.7 SDHB SDHC SDHD
23 serous surface papilloma 9.7 SDHB SDHC SDHD
24 non-syndromic male infertility due to sperm motility disorder 9.7 SDHB SDHC SDHD
25 neurofibromatosis-noonan syndrome 9.7 SDHB SDHC SDHD
26 childhood teratocarcinoma of the testis 9.7 SDHB SDHC SDHD
27 erythrocytosis, familial, 2 9.7 SDHB SDHC SDHD
28 obesity 9.7
29 cerebellar ataxia 9.7
30 diarrhea 9.7
31 ataxia 9.7
32 benign shuddering attacks 9.7 SDHB SDHC SDHD
33 amaurosis congenita, cone-rod type, with congenital hypertrichosis 9.6 SDHA SDHB SDHC SDHD
34 cowden syndrome 3 9.6 SDHA SDHB SDHC SDHD
35 gastrointestinal stromal tumor 9.5 SDHA SDHB SDHC SDHD
36 pheochromocytoma 9.5 SDHA SDHB SDHC SDHD
37 intravenous leiomyomatosis 9.5 SDHAF2 SDHB SDHC SDHD
38 endocervical adenocarcinoma 9.5 SDHAF2 SDHB SDHC SDHD
39 non-syndromic x-linked intellectual disability 9.5 SDHAF2 SDHB SDHC SDHD
40 neuropathy, congenital, with arthrogryposis multiplex 9.4 SDHA SDHAF2 SDHB SDHC SDHD
41 cardiac arrest 9.4 SDHA SDHAF2 SDHB SDHC SDHD
42 glycogen storage disease ic 9.4 SDHA SDHAF2 SDHB SDHC SDHD
43 isolated methylmalonic acidemia 9.4 SDHA SDHAF2 SDHB SDHC SDHD
44 carotenemia 9.4 SDHA SDHAF2 SDHB SDHC SDHD
45 zollinger-ellison syndrome 9.4 SDHA SDHAF2 SDHB SDHC SDHD

Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to Neural Crest Tumor

Symptoms & Phenotypes for Neural Crest Tumor

GenomeRNAi Phenotypes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.17 SDHC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.17 SDHC SDHD
3 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.17 SDHC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.17 SDHC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.17 SDHC SDHD

Drugs & Therapeutics for Neural Crest Tumor

Drugs for Neural Crest Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved Phase 2 38916-34-6, 51110-01-1 53481605
2 Hormone Antagonists Phase 2
3 Hormones Phase 2
4 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 177Lutetium-DOTA-Octreotate Therapy in Somatostatin Receptor-Expressing Neuroendocrine Neoplasms Active, not recruiting NCT01237457 Phase 2
2 I-123-MIBG for Imaging of Neuroblastoma and Pheochromocytoma Completed NCT00590096
3 Study of Molecular Pathways in Medullary Thyroid Carcinoma and Correlation of Molecular Data With Clinical Behavior of the MTC in Individuals Patients Completed NCT01424878
4 The Role of IMP3 Expression in Patients With Neuroblastoma Completed NCT01121419
5 Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions Recruiting NCT03160274
6 International Congenital Central Hypoventilation Syndrome (CCHS) Registry Recruiting NCT03088020

Search NIH Clinical Center for Neural Crest Tumor

Genetic Tests for Neural Crest Tumor

Anatomical Context for Neural Crest Tumor

Publications for Neural Crest Tumor

Articles related to Neural Crest Tumor:

(show all 11)
id Title Authors Year
1
Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. ( 23474632 )
2013
2
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. ( 23186956 )
2013
3
Thoracic neural crest tumors in Beckwith-Wiedemann syndrome. ( 14515390 )
2003
4
Neural-crest tumor presenting with chronic diarrhea: a report of three cases. ( 12632821 )
2002
5
Vanilmandelic acid and homovanillic acid levels in patients with neural crest tumor: 24-hour urine collection versus random sample. ( 9185210 )
1997
6
Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus). ( 8578645 )
1995
7
Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. ( 2068150 )
1991
8
Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases. ( 2748231 )
1989
9
Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model. ( 7105037 )
1982
10
Cerebellar ataxia, opsoclonus, and occult neural crest tumor. Abdominal computerized tomography in diagnosis. ( 7435465 )
1980
11
Convulsions with an occult neural-crest tumor. ( 460316 )
1979

Variations for Neural Crest Tumor

Expression for Neural Crest Tumor

Search GEO for disease gene expression data for Neural Crest Tumor.

Pathways for Neural Crest Tumor

GO Terms for Neural Crest Tumor

Cellular components related to Neural Crest Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.65 SDHA SDHAF2 SDHB SDHC SDHD
2 mitochondrial inner membrane GO:0005743 9.46 SDHA SDHB SDHC SDHD
3 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHA SDHB SDHC SDHD

Biological processes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.56 SDHA SDHB SDHC SDHD
2 aerobic respiration GO:0009060 9.37 SDHB SDHC
3 respiratory electron transport chain GO:0022904 9.32 SDHA SDHB
4 succinate metabolic process GO:0006105 9.16 SDHA SDHB
5 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.13 SDHA SDHAF2 SDHD
6 tricarboxylic acid cycle GO:0006099 9.02 SDHA SDHAF2 SDHB SDHC SDHD

Molecular functions related to Neural Crest Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 electron carrier activity GO:0009055 9.46 SDHA SDHB SDHC SDHD
2 heme binding GO:0020037 9.37 SDHC SDHD
3 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.32 SDHA SDHC
4 ubiquinone binding GO:0048039 9.26 SDHB SDHD
5 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.13 SDHA SDHB SDHD
6 succinate dehydrogenase activity GO:0000104 8.8 SDHA SDHC SDHD

Sources for Neural Crest Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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