MCID: NRL008
MIFTS: 29

Neural Crest Tumor malady

Rare diseases, Cancer diseases categories

Summaries for Neural Crest Tumor

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34MalaCards
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MalaCards: Neural Crest Tumor, also known as neural crest-derived tumors, is related to neuroblastoma and beckwith-wiedemann syndrome. An important gene associated with Neural Crest Tumor is SDHAF2 (succinate dehydrogenase complex assembly factor 2), and among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The compounds thenoyltrifluoroacetone and Ubiquinol 8 have been mentioned in the context of this disorder.

Aliases & Classifications for Neural Crest Tumor

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

neural crest tumor 44 63
neural crest-derived tumors 44


Related Diseases for Neural Crest Tumor

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to neural crest tumor

Symptoms for Neural Crest Tumor

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Drugs & Therapeutics for Neural Crest Tumor

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neural Crest Tumor

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Anatomical Context for Neural Crest Tumor

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Animal Models for Neural Crest Tumor or affiliated genes

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Publications for Neural Crest Tumor

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53PubMed
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Articles related to Neural Crest Tumor:

(show all 11)
idTitleAuthorsYear
1
Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. (23474632)
2013
2
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. (23186956)
2013
3
Thoracic neural crest tumors in Beckwith-Wiedemann syndrome. (14515390)
2003
4
Neural-crest tumor presenting with chronic diarrhea: a report of three cases. (12632821)
2002
5
Vanilmandelic acid and homovanillic acid levels in patients with neural crest tumor: 24-hour urine collection versus random sample. (9185210)
1997
6
Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus). (8578645)
1995
7
Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. (2068150)
1991
8
Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases. (2748231)
1989
9
Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model. (7105037)
1982
10
Cerebellar ataxia, opsoclonus, and occult neural crest tumor. Abdominal computerized tomography in diagnosis. (7435465)
1980
11
Convulsions with an occult neural-crest tumor. (460316)
1979

Variations for Neural Crest Tumor

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Expression for genes affiliated with Neural Crest Tumor

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neural Crest Tumor

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Pathways for genes affiliated with Neural Crest Tumor

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51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database, 52PharmGKB
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Pathways related to Neural Crest Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.1SDHA, SDHC, SDHD, SDHB
2
Show member pathways
8.1SDHB, SDHD, SDHC, SDHA
3
Show member pathways
Alzheimers Disease39
8.1SDHB, SDHD, SDHC, SDHA
4
Show member pathways
L-serine degradation39
pentose phosphate pathway (oxidative branch)39
formaldehyde oxidation II (glutathione-dependent)39
8.1SDHB, SDHD, SDHC, SDHA
5
Show member pathways
TCA cycle39
pyruvate decarboxylation to acetyl CoA39
NAD phosphorylation and dephosphorylation39
TCA Cycle39
conversion of glucose to acetyl CoA and entry into the TCA cycle39
8.1SDHA, SDHC, SDHD, SDHB

Compounds for genes affiliated with Neural Crest Tumor

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46Novoseek, 12DrugBank, 25HMDB, 30IUPHAR
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Compounds related to Neural Crest Tumor according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1thenoyltrifluoroacetone46 1210.4SDHA, SDHB
2Ubiquinol 8259.4SDHA, SDHB
3mibg469.4SDHD, SDHB
4heme30 25 1211.2SDHC, SDHD
5nad+469.0SDHA, SDHB
6catecholamine469.0SDHB, SDHD, NPY
7fumarate46 129.8SDHC, SDHD, SDHB
8Fumaric acid258.4SDHA, SDHC, SDHD, SDHB
9succinic acid30 25 1210.4SDHB, SDHD, SDHC, SDHA
10iron-sulfur468.4SDHB, SDHD, SDHC, SDHA
11ubiquinone468.4SDHB, SDHD, SDHC, SDHA
12Sulfide258.3SDHB, SDHD, SDHC, SDHA
13QH2258.3SDHA, SDHC, SDHD, SDHB
14Ubiquinone Q2258.3SDHB, SDHD, SDHC, SDHA
15Ubiquinone Q1258.3SDHA, SDHC, SDHD, SDHB
16succinate468.3SDHB, SDHD, SDHC, SDHA
17FAD258.3SDHB, SDHD, SDHC, SDHA
18iron46 259.2SDHA, SDHC, SDHD, SDHB
19oxygen46 259.0SDHB, SDHD, SDHC, SDHA

GO Terms for genes affiliated with Neural Crest Tumor

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17Gene Ontology
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Cellular components related to Neural Crest Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:0057498.0SDHB, SDHD, SDHC, SDHA
2mitochondrial inner membraneGO:0057437.8SDHB, SDHD, SDHC, SDHA
3mitochondrionGO:0057397.6SDHB, SDHD, SDHAF2, SDHC, SDHA

Biological processes related to Neural Crest Tumor according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1succinate metabolic processGO:0061059.3SDHB, SDHA
2oxidation-reduction processGO:0551149.1SDHA, SDHC
3aerobic respirationGO:0090608.9SDHB, SDHC
4tricarboxylic acid cycleGO:0060998.2SDHA, SDHC, SDHD, SDHB
5respiratory electron transport chainGO:0229048.2SDHB, SDHD, SDHC, SDHA
6cellular metabolic processGO:0442378.1SDHB, SDHA, SDHC, SDHD
7small molecule metabolic processGO:0442817.8SDHA, SDHC, SDHD, SDHB

Molecular functions related to Neural Crest Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:0081779.3SDHA, SDHB
2heme bindingGO:0200379.2SDHC, SDHD
3ubiquinone bindingGO:0480399.1SDHD, SDHB
4succinate dehydrogenase activityGO:0001048.7SDHA, SDHC, SDHD
5electron carrier activityGO:0090558.5SDHB, SDHD, SDHC

Products for genes affiliated with Neural Crest Tumor

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Neural Crest Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet