MCID: NRL008
MIFTS: 25

Neural Crest Tumor

Categories: Rare diseases

Aliases & Classifications for Neural Crest Tumor

MalaCards integrated aliases for Neural Crest Tumor:

Name: Neural Crest Tumor 50 69
Neural Crest-Derived Tumors 50

Classifications:



Summaries for Neural Crest Tumor

MalaCards based summary : Neural Crest Tumor, also known as neural crest-derived tumors, is related to paragangliomas 4 and paragangliomas 3. An important gene associated with Neural Crest Tumor is SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Carbon metabolism. The drugs Somatostatin and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include thyroid, and related phenotype is Increased shRNA abundance (Z-score > 2).

Related Diseases for Neural Crest Tumor

Diseases related to Neural Crest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
id Related Disease Score Top Affiliating Genes
1 paragangliomas 4 10.9
2 paragangliomas 3 10.9
3 paragangliomas 5 10.9
4 paragangliomas 2 10.9
5 paragangliomas 1, with or without deafness 10.9
6 salpingo-oophoritis 10.0 SDHA SDHD
7 cerebellar vermis medulloblastoma 10.0 SDHA SDHB
8 mental retardation with spastic paraplegia 9.9 SDHA SDHD
9 neuroblastoma 9.9
10 beckwith-wiedemann syndrome 9.9
11 glomangioma 9.8 SDHB SDHD
12 multiple endocrine neoplasia iib 9.8 SDHB SDHD
13 obesity 9.7
14 cerebellar ataxia 9.7
15 diarrhea 9.7
16 ataxia 9.7
17 immunodeficiency, common variable, 5 9.4 SDHB SDHD
18 sporadic hemiplegic migraine 9.3 SDHB SDHC
19 bjornstad syndrome 9.2 SDHA SDHB SDHD
20 carcinoid tumors, intestinal 9.2 SDHB SDHC SDHD
21 paraganglioma and gastric stromal sarcoma 9.2 SDHB SDHC SDHD
22 serous surface papilloma 9.2 SDHB SDHC SDHD
23 primary oculocerebral lymphoma 9.2 SDHB SDHC SDHD
24 pediatric supratentorial ependymoma 9.1 SDHB SDHC SDHD
25 erythrocytosis, familial, 2 9.1 SDHB SDHC SDHD
26 viral encephalitis 9.1 SDHB SDHC SDHD
27 benign shuddering attacks 9.1 SDHB SDHC SDHD
28 neurofibromatosis, familial spinal 9.1 SDHB SDHC SDHD
29 mercaptolactate-cysteine disulfiduria 8.8 SDHA SDHB SDHC SDHD
30 gastrointestinal stromal tumor 8.7 SDHA SDHB SDHC SDHD
31 pheochromocytoma 8.7 SDHA SDHB SDHC SDHD
32 rete ovarii cystadenoma 8.7 SDHAF2 SDHB SDHC SDHD
33 uterine corpus endometrial carcinoma 8.7 SDHAF2 SDHB SDHC SDHD
34 paraganglioma 8.7 SDHAF2 SDHB SDHC SDHD
35 neurogenic hypertension 8.3 SDHA SDHAF2 SDHB SDHC SDHD
36 lung abscess 8.3 SDHA SDHAF2 SDHB SDHC SDHD
37 hidrotic ectodermal dysplasia 2 8.3 SDHA SDHAF2 SDHB SDHC SDHD
38 glycogen storage disease ib 8.3 SDHA SDHAF2 SDHB SDHC SDHD
39 residual stage corticosteroid-induced glaucoma 8.3 SDHA SDHAF2 SDHB SDHC SDHD
40 opitz-gbbb syndrome 8.3 SDHA SDHAF2 SDHB SDHC SDHD

Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to Neural Crest Tumor

Symptoms & Phenotypes for Neural Crest Tumor

GenomeRNAi Phenotypes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.17 SDHC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-188 9.17 SDHC SDHD
3 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.17 SDHC
4 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.17 SDHC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.17 SDHC SDHD

Drugs & Therapeutics for Neural Crest Tumor

Drugs for Neural Crest Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Somatostatin Approved Phase 2 38916-34-6, 51110-01-1 53481605
2 Hormone Antagonists Phase 2
3 Hormones Phase 2
4 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 177Lutetium-DOTA-Octreotate Therapy in Somatostatin Receptor-Expressing Neuroendocrine Neoplasms Unknown status NCT01237457 Phase 2 177Lu-DOTATATE
2 I-123-MIBG for Imaging of Neuroblastoma and Pheochromocytoma Completed NCT00590096
3 Study of Molecular Pathways in Medullary Thyroid Carcinoma and Correlation of Molecular Data With Clinical Behavior of the MTC in Individuals Patients Completed NCT01424878
4 The Role of IMP3 Expression in Patients With Neuroblastoma Completed NCT01121419
5 Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions Recruiting NCT03160274
6 International Congenital Central Hypoventilation Syndrome (CCHS) Registry Recruiting NCT03088020

Search NIH Clinical Center for Neural Crest Tumor

Genetic Tests for Neural Crest Tumor

Anatomical Context for Neural Crest Tumor

MalaCards organs/tissues related to Neural Crest Tumor:

39
Thyroid

Publications for Neural Crest Tumor

Articles related to Neural Crest Tumor:

(show all 11)
id Title Authors Year
1
Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. ( 23474632 )
2013
2
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. ( 23186956 )
2013
3
Thoracic neural crest tumors in Beckwith-Wiedemann syndrome. ( 14515390 )
2003
4
Neural-crest tumor presenting with chronic diarrhea: a report of three cases. ( 12632821 )
2002
5
Vanilmandelic acid and homovanillic acid levels in patients with neural crest tumor: 24-hour urine collection versus random sample. ( 9185210 )
1997
6
Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus). ( 8578645 )
1995
7
Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. ( 2068150 )
1991
8
Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases. ( 2748231 )
1989
9
Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model. ( 7105037 )
1982
10
Cerebellar ataxia, opsoclonus, and occult neural crest tumor. Abdominal computerized tomography in diagnosis. ( 7435465 )
1980
11
Convulsions with an occult neural-crest tumor. ( 460316 )
1979

Variations for Neural Crest Tumor

Expression for Neural Crest Tumor

Search GEO for disease gene expression data for Neural Crest Tumor.

Pathways for Neural Crest Tumor

GO Terms for Neural Crest Tumor

Cellular components related to Neural Crest Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.65 SDHA SDHAF2 SDHB SDHC SDHD
2 mitochondrial inner membrane GO:0005743 9.46 SDHA SDHB SDHC SDHD
3 respiratory chain complex II GO:0045273 8.96 SDHB SDHC
4 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) GO:0005749 8.92 SDHA SDHB SDHC SDHD

Biological processes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.56 SDHA SDHB SDHC SDHD
2 aerobic respiration GO:0009060 9.37 SDHB SDHC
3 respiratory electron transport chain GO:0022904 9.32 SDHA SDHB
4 succinate metabolic process GO:0006105 9.16 SDHA SDHB
5 mitochondrial electron transport, succinate to ubiquinone GO:0006121 9.13 SDHA SDHAF2 SDHD
6 tricarboxylic acid cycle GO:0006099 9.02 SDHA SDHAF2 SDHB SDHC SDHD

Molecular functions related to Neural Crest Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 electron carrier activity GO:0009055 9.46 SDHA SDHB SDHC SDHD
2 heme binding GO:0020037 9.37 SDHC SDHD
3 oxidoreductase activity, acting on the CH-CH group of donors GO:0016627 9.32 SDHA SDHC
4 ubiquinone binding GO:0048039 9.26 SDHB SDHD
5 succinate dehydrogenase (ubiquinone) activity GO:0008177 9.13 SDHA SDHB SDHD
6 succinate dehydrogenase activity GO:0000104 8.8 SDHA SDHC SDHD

Sources for Neural Crest Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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