MCID: NRL008
MIFTS: 25

Neural Crest Tumor malady

Category: Rare diseases

Aliases & Classifications for Neural Crest Tumor

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Aliases & Descriptions for Neural Crest Tumor:

Name: Neural Crest Tumor 48 68
 
Neural Crest-Derived Tumors 48

Classifications:



Summaries for Neural Crest Tumor

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MalaCards based summary: Neural Crest Tumor, also known as neural crest-derived tumors, is related to paragangliomas 4 and paragangliomas 3. An important gene associated with Neural Crest Tumor is SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Carbon metabolism. Related mouse phenotype Increased shRNA abundance (Z-score > 2).

Related Diseases for Neural Crest Tumor

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Diseases related to Neural Crest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1paragangliomas 410.9
2paragangliomas 310.9
3paragangliomas 510.9
4paragangliomas 210.9
5paragangliomas 1, with or without deafness10.9
6acute salpingitis10.1SDHA, SDHD
7prolapse of female genital organ10.0SDHA, SDHD
8catastrophic antiphospholipid syndrome10.0SDHB, SDHD
9medullomyoblastoma10.0SDHA, SDHB
10acrocapitofemoral dysplasia10.0SDHB, SDHD
11bone ameloblastoma10.0SDHB, SDHD
12glomangioma10.0SDHB, SDHD
13central hypoventilation syndrome, congenital9.9SDHB, SDHD
14seborrheic dermatitis9.9SDHB, SDHD
15lumbar spinal canal and spinal cord meningioma9.9SDHB, SDHD
16neuroblastoma9.9
17beckwith-wiedemann syndrome9.9
18aneurysm9.8SDHB, SDHC
19leukemia, acute promyelocytic, somatic9.8SDHB, SDHD
20bjornstad syndrome9.8SDHA, SDHB, SDHD
21paraganglioma and gastric stromal sarcoma9.7SDHB, SDHC, SDHD
22glioma susceptibility 29.7SDHB, SDHC, SDHD
23serous surface papilloma9.7SDHB, SDHC, SDHD
24non-syndromic male infertility due to sperm motility disorder9.7SDHB, SDHC, SDHD
25neurofibromatosis-noonan syndrome9.7SDHB, SDHC, SDHD
26childhood teratocarcinoma of the testis9.7SDHB, SDHC, SDHD
27erythrocytosis, familial, 29.7SDHB, SDHC, SDHD
28obesity9.7
29cerebellar ataxia9.7
30diarrhea9.7
31ataxia9.7
32benign shuddering attacks9.7SDHB, SDHC, SDHD
33amaurosis congenita, cone-rod type, with congenital hypertrichosis9.6SDHA, SDHB, SDHC, SDHD
34cowden syndrome 39.6SDHA, SDHB, SDHC, SDHD
35gastrointestinal stromal tumor9.5SDHA, SDHB, SDHC, SDHD
36pheochromocytoma9.5SDHA, SDHB, SDHC, SDHD
37intravenous leiomyomatosis9.5SDHAF2, SDHB, SDHC, SDHD
38endocervical adenocarcinoma9.5SDHAF2, SDHB, SDHC, SDHD
39non-syndromic x-linked intellectual disability9.5SDHAF2, SDHB, SDHC, SDHD
40neuropathy, congenital, with arthrogryposis multiplex9.4SDHA, SDHAF2, SDHB, SDHC, SDHD
41cardiac arrest9.4SDHA, SDHAF2, SDHB, SDHC, SDHD
42glycogen storage disease ic9.4SDHA, SDHAF2, SDHB, SDHC, SDHD
43isolated methylmalonic acidemia9.4SDHA, SDHAF2, SDHB, SDHC, SDHD
44carotenemia9.4SDHA, SDHAF2, SDHB, SDHC, SDHD
45zollinger-ellison syndrome9.4SDHA, SDHAF2, SDHB, SDHC, SDHD

Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to neural crest tumor

Symptoms & Phenotypes for Neural Crest Tumor

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GenomeRNAi Phenotypes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-1929.1SDHC, SDHD

Drugs & Therapeutics for Neural Crest Tumor

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Drugs for Neural Crest Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SomatostatinapprovedPhase 223738916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
2Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 213168
3HormonesPhase 214415
4Hormone AntagonistsPhase 213180

Interventional clinical trials:

idNameStatusNCT IDPhase
1177Lutetium-DOTA-Octreotate Therapy in Somatostatin Receptor-Expressing Neuroendocrine NeoplasmsActive, not recruitingNCT01237457Phase 2
2I-123-MIBG for Imaging of Neuroblastoma and PheochromocytomaCompletedNCT00590096
3Study of Molecular Pathways in Medullary Thyroid Carcinoma and Correlation of Molecular Data With Clinical Behavior of the MTC in Individuals PatientsCompletedNCT01424878
4The Role of IMP3 Expression in Patients With NeuroblastomaCompletedNCT01121419
5Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated ConditionsRecruitingNCT03160274
6International Congenital Central Hypoventilation Syndrome (CCHS) RegistryRecruitingNCT03088020

Search NIH Clinical Center for Neural Crest Tumor

Genetic Tests for Neural Crest Tumor

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Anatomical Context for Neural Crest Tumor

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Publications for Neural Crest Tumor

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Articles related to Neural Crest Tumor:

(show all 11)
idTitleAuthorsYear
1
Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. (23474632)
2013
2
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. (23186956)
2013
3
Thoracic neural crest tumors in Beckwith-Wiedemann syndrome. (14515390)
2003
4
Neural-crest tumor presenting with chronic diarrhea: a report of three cases. (12632821)
2002
5
Vanilmandelic acid and homovanillic acid levels in patients with neural crest tumor: 24-hour urine collection versus random sample. (9185210)
1997
6
Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus). (8578645)
1995
7
Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. (2068150)
1991
8
Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases. (2748231)
1989
9
Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model. (7105037)
1982
10
Cerebellar ataxia, opsoclonus, and occult neural crest tumor. Abdominal computerized tomography in diagnosis. (7435465)
1980
11
Convulsions with an occult neural-crest tumor. (460316)
1979

Variations for Neural Crest Tumor

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Expression for genes affiliated with Neural Crest Tumor

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Search GEO for disease gene expression data for Neural Crest Tumor.

Pathways for genes affiliated with Neural Crest Tumor

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GO Terms for genes affiliated with Neural Crest Tumor

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Cellular components related to Neural Crest Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1respiratory chain complex IIGO:00452739.0SDHB, SDHC
2mitochondrial inner membraneGO:00057438.8SDHA, SDHB, SDHC, SDHD
3mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)GO:00057498.8SDHA, SDHB, SDHC, SDHD
4mitochondrionGO:00057397.4SDHA, SDHAF2, SDHB, SDHC, SDHD

Biological processes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1respiratory electron transport chainGO:00229049.8SDHA, SDHB
2succinate metabolic processGO:00061059.8SDHA, SDHB
3aerobic respirationGO:00090609.7SDHB, SDHC
4mitochondrial electron transport, succinate to ubiquinoneGO:00061219.7SDHA, SDHAF2, SDHD
5oxidation-reduction processGO:00551148.5SDHA, SDHB, SDHC, SDHD
6tricarboxylic acid cycleGO:00060997.5SDHA, SDHAF2, SDHB, SDHC, SDHD

Molecular functions related to Neural Crest Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:00200379.6SDHC, SDHD
2oxidoreductase activity, acting on the CH-CH group of donorsGO:00166279.5SDHA, SDHC
3ubiquinone bindingGO:00480399.3SDHB, SDHD
4succinate dehydrogenase (ubiquinone) activityGO:00081779.1SDHA, SDHB, SDHD
5succinate dehydrogenase activityGO:00001048.8SDHA, SDHC, SDHD
6electron carrier activityGO:00090558.6SDHA, SDHB, SDHC, SDHD

Sources for Neural Crest Tumor

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet