MCID: NRL008
MIFTS: 29

Neural Crest Tumor malady

Rare diseases, Cancer diseases categories

Summaries for Neural Crest Tumor

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MalaCards based summary: Neural Crest Tumor, also known as neural crest-derived tumors, is related to neuroblastoma and paragangliomas 5. An important gene associated with Neural Crest Tumor is SDHAF2 (succinate dehydrogenase complex assembly factor 2), and among its related pathways are Metabolism and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. The compounds thenoyltrifluoroacetone and Ubiquinol 8 have been mentioned in the context of this disorder.

Aliases & Classifications for Neural Crest Tumor

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Neural Crest Tumor, Aliases & Descriptions:

Name: Neural Crest Tumor 42 61
 
Neural Crest-Derived Tumors 42 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Neural Crest Tumor

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Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to neural crest tumor

Symptoms for Neural Crest Tumor

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Drugs & Therapeutics for Neural Crest Tumor

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Drug clinical trials:

Search ClinicalTrials for Neural Crest Tumor

Search NIH Clinical Center for Neural Crest Tumor

Genetic Tests for Neural Crest Tumor

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Anatomical Context for Neural Crest Tumor

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Animal Models for Neural Crest Tumor or affiliated genes

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Publications for Neural Crest Tumor

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Articles related to Neural Crest Tumor:

(show all 11)
idTitleAuthorsYear
1
Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. (23474632)
2013
2
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. (23186956)
2013
3
Thoracic neural crest tumors in Beckwith-Wiedemann syndrome. (14515390)
2003
4
Neural-crest tumor presenting with chronic diarrhea: a report of three cases. (12632821)
2002
5
Vanilmandelic acid and homovanillic acid levels in patients with neural crest tumor: 24-hour urine collection versus random sample. (9185210)
1997
6
Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus). (8578645)
1995
7
Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. (2068150)
1991
8
Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases. (2748231)
1989
9
Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model. (7105037)
1982
10
Cerebellar ataxia, opsoclonus, and occult neural crest tumor. Abdominal computerized tomography in diagnosis. (7435465)
1980
11
Convulsions with an occult neural-crest tumor. (460316)
1979

Variations for Neural Crest Tumor

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Expression for genes affiliated with Neural Crest Tumor

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Expression patterns in normal tissues for genes affiliated with Neural Crest Tumor

Search GEO for disease gene expression data for Neural Crest Tumor.

Pathways for genes affiliated with Neural Crest Tumor

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Pathways related to Neural Crest Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
8.1SDHA, SDHC, SDHD, SDHB
2
Show member pathways
8.1SDHB, SDHD, SDHC, SDHA
3
Show member pathways
Alzheimers Disease37
8.1SDHB, SDHD, SDHC, SDHA
4
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
8.1SDHB, SDHD, SDHC, SDHA
5
Show member pathways
TCA cycle37
pyruvate decarboxylation to acetyl CoA37
NAD phosphorylation and dephosphorylation37
TCA Cycle37
conversion of glucose to acetyl CoA and entry into the TCA cycle37
8.1SDHA, SDHC, SDHD, SDHB

Compounds for genes affiliated with Neural Crest Tumor

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Sources:
44Novoseek, 12DrugBank, 25HMDB, 29IUPHAR
See all sources

Compounds related to Neural Crest Tumor according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1thenoyltrifluoroacetone44 1210.4SDHA, SDHB
2Ubiquinol 8259.4SDHA, SDHB
3mibg449.4SDHD, SDHB
4heme29 25 1211.2SDHC, SDHD
5nad+449.0SDHA, SDHB
6catecholamine449.0SDHB, SDHD, NPY
7fumarate44 129.8SDHC, SDHD, SDHB
8Fumaric acid258.4SDHA, SDHC, SDHD, SDHB
9succinic acid29 25 1210.4SDHB, SDHD, SDHC, SDHA
10iron-sulfur448.4SDHB, SDHD, SDHC, SDHA
11ubiquinone448.4SDHB, SDHD, SDHC, SDHA
12Sulfide258.3SDHB, SDHD, SDHC, SDHA
13QH2258.3SDHA, SDHC, SDHD, SDHB
14Ubiquinone Q2258.3SDHB, SDHD, SDHC, SDHA
15Ubiquinone Q1258.3SDHA, SDHC, SDHD, SDHB
16succinate448.3SDHB, SDHD, SDHC, SDHA
17FAD258.3SDHB, SDHD, SDHC, SDHA
18iron44 259.2SDHA, SDHC, SDHD, SDHB
19oxygen44 259.0SDHB, SDHD, SDHC, SDHA

GO Terms for genes affiliated with Neural Crest Tumor

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Cellular components related to Neural Crest Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial respiratory chain complex IIGO:0057498.0SDHA, SDHC, SDHD, SDHB
2mitochondrial inner membraneGO:0057437.8SDHB, SDHD, SDHC, SDHA
3mitochondrionGO:0057397.6SDHA, SDHC, SDHAF2, SDHD, SDHB

Biological processes related to Neural Crest Tumor according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1succinate metabolic processGO:0061059.3SDHA, SDHB
2oxidation-reduction processGO:0551149.1SDHA, SDHC
3aerobic respirationGO:0090608.9SDHC, SDHB
4tricarboxylic acid cycleGO:0060998.2SDHA, SDHC, SDHD, SDHB
5respiratory electron transport chainGO:0229048.2SDHB, SDHD, SDHC, SDHA
6cellular metabolic processGO:0442378.1SDHB, SDHD, SDHC, SDHA
7small molecule metabolic processGO:0442817.8SDHB, SDHD, SDHC, SDHA

Molecular functions related to Neural Crest Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:0081779.3SDHA, SDHB
2heme bindingGO:0200379.2SDHC, SDHD
3ubiquinone bindingGO:0480399.1SDHD, SDHB
4succinate dehydrogenase activityGO:0001048.7SDHA, SDHC, SDHD
5electron carrier activityGO:0090558.5SDHB, SDHD, SDHC

Products for genes affiliated with Neural Crest Tumor

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Neural Crest Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet