MCID: NRL008
MIFTS: 25

Neural Crest Tumor malady

Category: Rare diseases

Aliases & Classifications for Neural Crest Tumor

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Aliases & Descriptions for Neural Crest Tumor:

Name: Neural Crest Tumor 47 67
 
Neural Crest-Derived Tumors 47

Classifications:



Summaries for Neural Crest Tumor

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MalaCards based summary: Neural Crest Tumor, also known as neural crest-derived tumors, is related to paragangliomas 5 and paragangliomas 4. An important gene associated with Neural Crest Tumor is SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Carbon metabolism. Affiliated tissues include thyroid.

Related Diseases for Neural Crest Tumor

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Diseases related to Neural Crest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1paragangliomas 531.5SDHA, SDHB
2paragangliomas 431.4SDHA, SDHB
3paragangliomas 311.0
4paragangliomas 211.0
5paragangliomas 1, with or without deafness11.0
6cowden syndrome 210.0SDHA, SDHB
7albinism, oculocutaneous, type iv10.0SDHA, SDHB
8salpingo-oophoritis10.0SDHA, SDHD
9thyroid crisis10.0SDHA, SDHD
10retinoschisis autosomal dominant10.0SDHB, SDHD
11large cell medulloblastoma9.9SDHA, SDHB
12ameloblastoma9.9SDHB, SDHD
13mental retardation with spastic paraplegia9.9SDHA, SDHD
14neuroblastoma9.9
15beckwith-wiedemann syndrome9.9
16pancreatitis, pediatric9.7SDHC, SDHD
17pediatric infratentorial ependymoma9.7SDHB, SDHD
18obesity9.7
19cerebellar ataxia9.7
20diarrhea9.7
21ataxia9.7
22immunodeficiency, common variable, 59.6SDHB, SDHD
23in situ carcinoma9.5SDHB, SDHD
24leigh syndrome9.4SDHA, SDHB, SDHD
25torticollis, familial9.3SDHB, SDHC, SDHD
26carcinoid tumors, intestinal9.3SDHB, SDHC, SDHD
27sporadic secreting paraganglioma9.3SDHB, SDHC, SDHD
28neurofibromatosis-noonan syndrome9.3SDHB, SDHC, SDHD
29lipoma of the rectum9.3SDHB, SDHC, SDHD
30von hippel-lindau syndrome9.3SDHB, SDHC, SDHD
31paraganglioma and gastric stromal sarcoma8.9SDHA, SDHB, SDHC, SDHD
32mercaptolactate-cysteine disulfiduria8.9SDHA, SDHB, SDHC, SDHD
33endocrine gland cancer8.9SDHA, SDHB, SDHC, SDHD
34tumor predisposition syndrome8.9SDHA, SDHB, SDHC, SDHD
35gastrointestinal stromal tumor8.9SDHA, SDHB, SDHC, SDHD
36pheochromocytoma8.9SDHA, SDHB, SDHC, SDHD
37seminal vesicle cystadenoma8.9SDHAF2, SDHB, SDHC, SDHD
38uterine corpus endometrial carcinoma8.9SDHAF2, SDHB, SDHC, SDHD
39richter's syndrome8.9SDHAF2, SDHB, SDHC, SDHD
40neuroendocrine carcinoma of the cervix8.5SDHA, SDHAF2, SDHB, SDHC, SDHD
41lung abscess8.5SDHA, SDHAF2, SDHB, SDHC, SDHD
42hidrotic ectodermal dysplasia 28.5SDHA, SDHAF2, SDHB, SDHC, SDHD
43steroid-induced glaucoma8.5SDHA, SDHAF2, SDHB, SDHC, SDHD
44glycogen storage disease ib8.5SDHA, SDHAF2, SDHB, SDHC, SDHD

Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to neural crest tumor

Symptoms for Neural Crest Tumor

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Drugs & Therapeutics for Neural Crest Tumor

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Drugs for Neural Crest Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SomatostatinapprovedPhase 222938916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
2Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 212767
3HormonesPhase 213979
4Hormone AntagonistsPhase 212778

Interventional clinical trials:

idNameStatusNCT IDPhase
1177Lutetium-DOTA-Octreotate Therapy in Somatostatin Receptor-Expressing Neuroendocrine NeoplasmsActive, not recruitingNCT01237457Phase 2
2I-123-MIBG for Imaging of Neuroblastoma and PheochromocytomaCompletedNCT00590096
3Study of Molecular Pathways in Medullary Thyroid Carcinoma and Correlation of Molecular Data With Clinical Behavior of the MTC in Individuals PatientsCompletedNCT01424878
4The Role of IMP3 Expression in Patients With NeuroblastomaCompletedNCT01121419

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Genetic Tests for Neural Crest Tumor

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Anatomical Context for Neural Crest Tumor

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MalaCards organs/tissues related to Neural Crest Tumor:

35
Thyroid

Animal Models for Neural Crest Tumor or affiliated genes

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Publications for Neural Crest Tumor

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Articles related to Neural Crest Tumor:

(show all 11)
idTitleAuthorsYear
1
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. (23186956)
2013
2
Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. (23474632)
2013
3
Thoracic neural crest tumors in Beckwith-Wiedemann syndrome. (14515390)
2003
4
Neural-crest tumor presenting with chronic diarrhea: a report of three cases. (12632821)
2002
5
Vanilmandelic acid and homovanillic acid levels in patients with neural crest tumor: 24-hour urine collection versus random sample. (9185210)
1997
6
Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus). (8578645)
1995
7
Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. (2068150)
1991
8
Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases. (2748231)
1989
9
Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model. (7105037)
1982
10
Cerebellar ataxia, opsoclonus, and occult neural crest tumor. Abdominal computerized tomography in diagnosis. (7435465)
1980
11
Convulsions with an occult neural-crest tumor. (460316)
1979

Variations for Neural Crest Tumor

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Expression for genes affiliated with Neural Crest Tumor

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Search GEO for disease gene expression data for Neural Crest Tumor.

Pathways for genes affiliated with Neural Crest Tumor

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GO Terms for genes affiliated with Neural Crest Tumor

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Cellular components related to Neural Crest Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1respiratory chain complex IIGO:00452739.7SDHB, SDHC
2mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)GO:00057498.7SDHA, SDHB, SDHC, SDHD
3mitochondrial inner membraneGO:00057438.1SDHA, SDHB, SDHC, SDHD
4mitochondrionGO:00057397.5SDHA, SDHAF2, SDHB, SDHC, SDHD

Biological processes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1succinate metabolic processGO:00061059.8SDHA, SDHB
2mitochondrial electron transport, succinate to ubiquinoneGO:00061219.5SDHAF2, SDHC
3respiratory electron transport chainGO:00229049.5SDHA, SDHB
4aerobic respirationGO:00090609.2SDHB, SDHC
5tricarboxylic acid cycleGO:00060998.1SDHA, SDHB, SDHC, SDHD

Molecular functions related to Neural Crest Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:00081779.9SDHA, SDHB
2ubiquinone bindingGO:00480399.5SDHB, SDHD
3succinate dehydrogenase activityGO:00001049.2SDHA, SDHC, SDHD
4heme bindingGO:00200378.8SDHC, SDHD
5electron carrier activityGO:00090558.5SDHB, SDHC, SDHD

Sources for Neural Crest Tumor

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet