MCID: NRL008
MIFTS: 28

Neural Crest Tumor malady

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Neural Crest Tumor

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Aliases & Descriptions for Neural Crest Tumor:

Name: Neural Crest Tumor 45 65
 
Neural Crest-Derived Tumors 45

Classifications:



External Ids:

UMLS65 C2931189

Summaries for Neural Crest Tumor

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MalaCards based summary: Neural Crest Tumor, also known as neural crest-derived tumors, is related to paragangliomas 5 and paragangliomas 4. An important gene associated with Neural Crest Tumor is SDHA (Succinate Dehydrogenase Complex Flavoprotein Subunit A), and among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Alzheimers disease. Affiliated tissues include thyroid and endothelial.

Related Diseases for Neural Crest Tumor

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Diseases related to Neural Crest Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1paragangliomas 530.2SDHA, SDHB
2paragangliomas 430.2SDHA, SDHB
3cowden syndrome 210.1SDHA, SDHB
4paragangliomas 310.1
5paragangliomas 210.1
6paragangliomas 1, with or without deafness10.1
7albinism, oculocutaneous, type iv10.1SDHA, SDHB
8acute salpingo-oophoritis10.1SDHA, SDHD
9senile entropion10.0SDHA, SDHD
10cataract hutterite type10.0SDHB, SDHD
11male reproductive organ cancer10.0SDHA, SDHB
12gallbladder adenoma10.0SDHB, SDHD
13neuroblastoma10.0
14beckwith-wiedemann syndrome10.0
15cataract 4, multiple types10.0SDHB, SDHD
16epidermal appendage tumor9.9SDHB, SDHD
17obesity9.8
18cerebellar ataxia9.8
19diarrhea9.8
20ataxia9.8
21multiple endocrine neoplasia iib9.8SDHB, SDHD
22peptic ulcer disease9.7SDHB, SDHD
23immunodeficiency, common variable, 59.7SDHB, SDHD
24alcoholic cardiomyopathy9.6SDHA, SDHD
25myopathy with deficiency of iron-sulfur cluster assembly enzyme9.4SDHC, SDHD
26leigh syndrome9.4SDHA, SDHB, SDHD
27familial stomach cancer9.3SDHB, SDHC, SDHD
28carcinoid tumors, intestinal9.3SDHB, SDHC, SDHD
29adenomyoma9.3SDHB, SDHC, SDHD
30sporadic pheochromocytoma/secreting paraganglioma9.3SDHB, SDHC, SDHD
31neurofibromatosis, familial spinal9.3SDHB, SDHC, SDHD
32von hippel-lindau syndrome9.3SDHB, SDHC, SDHD
33cerebellar liponeurocytoma9.3SDHB, SDHC, SDHD
34steroid inherited metabolic disorder9.3SDHB, SDHC, SDHD
35decubitus ulcer9.2SDHB, SDHC, SDHD
36paraganglioma and gastric stromal sarcoma8.9SDHA, SDHB, SDHC, SDHD
37carnitine palmitoyltransferase i deficiency , muscle8.9SDHA, SDHB, SDHC, SDHD
38glycogen storage disease ib8.9SDHA, SDHB, SDHC, SDHD
39gastrointestinal stromal tumor8.9SDHA, SDHB, SDHC, SDHD
40pheochromocytoma8.8SDHA, SDHB, SDHC, SDHD
41mononeuritis of upper limb and mononeuritis multiplex8.8SDHAF2, SDHB, SDHC, SDHD
42retroperitoneal neuroblastoma8.8SDHAF2, SDHB, SDHC, SDHD
43spastic ataxia 18.8SDHAF2, SDHB, SDHC, SDHD
44neuroaxonal dystrophy renal tubular acidosis8.4SDHA, SDHAF2, SDHB, SDHC, SDHD
45oral hairy leukoplakia8.4SDHA, SDHAF2, SDHB, SDHC, SDHD
46constant exophthalmos8.4SDHA, SDHAF2, SDHB, SDHC, SDHD
47heritable pulmonary arterial hypertension8.4SDHA, SDHAF2, SDHB, SDHC, SDHD
48non-syndromic x-linked intellectual disability8.4SDHA, SDHAF2, SDHB, SDHC, SDHD

Graphical network of the top 20 diseases related to Neural Crest Tumor:



Diseases related to neural crest tumor

Symptoms for Neural Crest Tumor

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Drugs & Therapeutics for Neural Crest Tumor

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Drugs for Neural Crest Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SomatostatinPhase 215351110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
2Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 29988
3HormonesPhase 211748
4Hormone AntagonistsPhase 210002

Interventional clinical trials:

idNameStatusNCT IDPhase
1177Lutetium-DOTA-Octreotate Therapy in Somatostatin Receptor-Expressing Neuroendocrine NeoplasmsActive, not recruitingNCT01237457Phase 2
2I-123-MIBG for Imaging of Neuroblastoma and PheochromocytomaCompletedNCT00590096
3Study of Molecular Pathways in Medullary Thyroid Carcinoma and Correlation of Molecular Data With Clinical Behavior of the MTC in Individuals PatientsCompletedNCT01424878
4The Role of IMP3 Expression in Patients With NeuroblastomaCompletedNCT01121419

Search NIH Clinical Center for Neural Crest Tumor

Genetic Tests for Neural Crest Tumor

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Anatomical Context for Neural Crest Tumor

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MalaCards organs/tissues related to Neural Crest Tumor:

33
Thyroid, Endothelial

Animal Models for Neural Crest Tumor or affiliated genes

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MGI Mouse Phenotypes related to Neural Crest Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Neural Crest Tumor

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Articles related to Neural Crest Tumor:

(show all 11)
idTitleAuthorsYear
1
Comparison of [123I]MIBG and [131I]MIBG for imaging of neuroblastoma and other neural crest tumors. (23474632)
2013
2
A case of rapid-onset obesity with hypothalamic dysfunction, hypoventilation, autonomic dysregulation, and neural crest tumor: ROHHADNET syndrome. (23186956)
2013
3
Thoracic neural crest tumors in Beckwith-Wiedemann syndrome. (14515390)
2003
4
Neural-crest tumor presenting with chronic diarrhea: a report of three cases. (12632821)
2002
5
Vanilmandelic acid and homovanillic acid levels in patients with neural crest tumor: 24-hour urine collection versus random sample. (9185210)
1997
6
Malignant melanocytic neural crest tumor in a young chicken (Gallus domesticus). (8578645)
1995
7
Characterization of neuropeptide Y in pediatric neural crest tumors: relation to tumor malignancy and genetic findings. (2068150)
1991
8
Beckwith-wiedemann syndrome and neural crest tumors. A report of two cases. (2748231)
1989
9
Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model. (7105037)
1982
10
Cerebellar ataxia, opsoclonus, and occult neural crest tumor. Abdominal computerized tomography in diagnosis. (7435465)
1980
11
Convulsions with an occult neural-crest tumor. (460316)
1979

Variations for Neural Crest Tumor

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Expression for genes affiliated with Neural Crest Tumor

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Search GEO for disease gene expression data for Neural Crest Tumor.

Pathways for genes affiliated with Neural Crest Tumor

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GO Terms for genes affiliated with Neural Crest Tumor

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Biological processes related to Neural Crest Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1succinate metabolic processGO:00061059.4SDHA, SDHB

Molecular functions related to Neural Crest Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1succinate dehydrogenase (ubiquinone) activityGO:00081779.9SDHA, SDHB
2oxidoreductase activity, acting on the CH-CH group of donorsGO:00166279.5SDHA, SDHC
3oxidoreductase activityGO:00164919.4SDHA, SDHB
4electron carrier activityGO:00090559.2SDHB, SDHD

Sources for Neural Crest Tumor

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet