Neural Tube Defect malady

MedlinePlus: Neural tube defects are birth defects of the brain and spinal cord. the two most common neural tube defects are spina bifida and anencephaly. in spina bifida, the fetal spinal column doesn't close completely during the first month of pregnancy. there is usually nerve damage that causes at least some paralysis of the legs. in anencephaly, much of the brain does not develop. babies with anencephaly are either stillborn or die shortly after birth. getting enough folic acid, a type of b vitamin, before and during pregnancy prevents most neural tube defects. treatments for neural tube defects vary depending on the type of defect. nih: national institute of child health and human development²³

MalaCards: Neural Tube Defect, also known as neural tube defects, is related to down syndrome and anencephaly. An important gene associated with Neural Tube Defect is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are Vitamin digestion and absorption and Antimetabolite Pathway - Folate Cycle, Pharmacodynamics. The compounds b vitamins and 5,10-methenyltetrahydrofolate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and monocytes, and related mouse phenotypes are hematopoietic system and pigmentation.

CDC: Neglected Tropical Diseases (NTDs) are a group of parasitic and bacterial diseases that cause substantial illness for more than one billion people globally. Affecting the world's poorest people, NTDs impair physical and cognitive development, contribute to mother and child illness and death, make it difficult to farm or earn a living, and limit productivity in the workplace. As a result, NTDs trap the poor in a cycle of poverty and disease.²

Wikipedia: Neural tube defects (NTDs) are one of the most common birth defects, occurring in approximately one in...⁴⁴ more...

OMIM: 182940

neural tube defect 16 neural tube defects 17 33 32 23 neurotic disorders 43 spina bifida 16

anencephaly 16 ntd 16

Diseases related to neural tube defect by text searches and GeneDecks gene sharing:

(show top 50)    (show all 370)

id	Related Disease	Score	Top Affiliating Genes
1	down syndrome	35.4	MTRR, CGA, CGB, CGB5, CGB7, AFP
2	anencephaly	32.8	VANGL1, BCHE, MTRR, MTHFR, MTR, MTHFD1
3	orofacial cleft	32.4	NAT1, NAT2, BMP4, BHMT, MTRR, MTHFR
4	myelomeningocele	32.4	VANGL1, PAX3, MTRR, MTHFR, MTR, MTHFD1
5	waardenburg's syndrome	32.2	KIR2DS4, PAX1, PAX3, SNAI2
6	birth defects	31.8	BMP4, MTRR, MTHFR, MTR, MTHFD1, CGB5
7	congenital diaphragmatic hernia	30.6	RARB, PAX3, CGB7, ALDH1A2, CYP26A1, PDGFRA
8	congenital heart defect	30.6	RFC1, ZIC3, BHMT, MTRR, MTHFR, MTR
9	porencephaly	30.2	MTHFR, F5, F2
10	thrombophilia	30.0	MTRR, MTHFR, MTHFD1, F5, F2, CBS
11	homocysteine	30.0	RFC1, PCNA, NAT1, NAT2, BHMT, BCHE
12	spina bifida	29.9	RFC1, NAP1L2, NAT1, NAT2, BRCA1, VANGL1
13	hydrocephalus	29.7	ZIC3, MTHFR, ALDH1L1, TP53, ACHE, AFP
14	hernia	29.6	RARB, PAX3, CGB7, CCL2, F2, ALDH1A2
15	vascular disease	29.5	BHMT, MTRR, MTHFR, MTR, CCL2, F5
16	twinning	29.0	BRCA1, ZIC2, PAX9, LEPR, MTHFR, MTR
17	diabetes mellitus	26.4	LRP6, NAT1, NAT2, BMP4, BCHE, LEPR
18	schizophrenia	24.4	PCNA, NAT1, NAT2, RARB, ZIC2, BCHE
19	adult acute lymphocytic leukemia	13.9	MTHFR, MTR, SHMT1, TYMS
20	thiamine-responsive megaloblastic anemia syndrome	13.9	MTRR, MTHFR, MTR, TCN2, SLC19A2
21	vitamin b12 deficiency	13.9	MTHFR, MTR, TCN1, TCN2
22	nonseminomatous germ cell tumor	13.9	CGA, CGB, CGB5, CGB7, AFP
23	extragonadal germ cell tumor	13.9	CGB, CGB5, AFP
24	ectopic pregnancy	13.9	CGA, CGB, CGB5, CGB7
25	mixed ductal-endocrine carcinoma	13.9	CGB, CGB5, CGB7
26	mature teratoma	13.9	CGA, CGB, AFP
27	methylmalonic aciduria and homocystinuria	13.9	MUT, MTR, CBS, TCN2
28	cblf	13.8	MUT, MTR, TCN2
29	placental site trophoblastic tumor	13.8	CGA, CGB, CGB5
30	germinoma	13.8	CGA, CGB, CGB5, CGB7, TRIM26, AFP
31	cutis marmorata telangiectatica congenita	13.8	MUT, CGA, AFP
32	hyperopia	13.8	VANGL1, VANGL2, MSX2, FZD6, NOG
33	folic acid deficiency anemia	13.7	MTHFR, MTR, FOLR1, CBS, TYMS, DHFR
34	methylmalonic acidemia	13.7	MUT, MTR, TCN2
35	acute lymphocytic leukemia	13.7	MTHFR, MTR, SHMT1, TYMS, DHFR, SLC19A1
36	endodermal sinus tumor	13.7	CGB, CGB5, AFP
37	craniofacial anomalies	13.6	KIR2DS4, PAX3, MSX2
38	phenylketonuria	13.6	MTRR, MTHFR, MTR, S100B, FOLH1, ACHE
39	dysgerminoma	13.6	BRCA1, CGA, CGB, CGB5, AFP
40	homocysteinemia	13.6	MTRR, MTHFR, MTR, F5, CBS, SLC19A1
41	arterial occlusive disease	13.6	MTHFR, CCL2, CBS
42	sacrococcygeal teratoma	13.5	PCNA, CGA, CGB7, AFP
43	gestational trophoblastic tumor	13.5	PCNA, CGA, CGB, CGB5
44	gastric adenocarcinoma	13.5	NAT1, NAT2, CGB7, TERC, TYMS, AFP
45	ovarian cyst	13.5	CGA, CGB5, SLC25A13, AFP
46	digeorge syndrome	13.5	MTHFR, CD40LG, ALDH1A2, CYP26A1, CYP26B1, DVL1
47	cardia cancer	13.4	MTRR, MTHFR, TP53, TYMS
48	triploidy	13.4	CGA, CGB, TP53
49	benign mesothelioma	13.4	CDH2, FOLR1, TYMS, DHFR, SLC19A1
50	cryptococcosis	13.4	CGB, CGB5, CGB7, CD40LG, F2

Clinical features from OMIM: 182940

Approved drugs:

Drug clinical trials:

Genetic tests related to neural tube defect:

id	Genetic test	Affiliating Genes
1	Neural Tube Defect clinical/research

MalaCards organs/tissues related to neural tube defect:

²²

MGI Mouse Phenotypes related to neural tube defect:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	9.1	SLC19A1, PCNA, BMP4, ZIC3, PAX1, CXCL6
2	pigmentation phenotype	MP:0001186	8.9	BRCA1, SNAI2, TERC, TP53, MAB21L1, FOXN1
3	liver/biliary system phenotype	MP:0005370	8.9	LRP6, MUT, SLC25A13, SLC19A1, SHMT1, CYP1A2
4	endocrine/exocrine gland phenotype	MP:0005379	8.4	CYP1A2, CYP26B1, SNAI2, NOG, SLC19A2, SLC19A1
5	renal/urinary system phenotype	MP:0005367	8.4	MUT, LEPR, CBS, ALDH1A2, MAB21L1, CYP26A1
6	craniofacial phenotype	MP:0005382	8.1	LRP6, VANGL2, BMP4, ZIC3, ACHE, DVL2
7	no phenotypic analysis	MP:0003012	8.1	CYP26B1, CYP26A1, CYP1A2, PCNA, TP53, T
8	immune system phenotype	MP:0005387	7.9	ALDH1A2, CBS, TP53, TERC, SNAI2, PDGFRA
9	muscle phenotype	MP:0005369	7.7	CDH2, CCL2, ALDH1A2, CBS, TP53, TERC
10	normal phenotype	MP:0002873	7.7	NOG, VANGL2, LRP6, PAX7, NAT1, BRCA1
11	tumorigenesis	MP:0002006	7.5	LEPR, AFP, SHMT1, PDGFRA, TERC, TP53
12	reproductive system phenotype	MP:0005389	7.4	LRP6, NAT1, BRCA1, VANGL1, VANGL2, RARB
13	respiratory system phenotype	MP:0005388	7.3	LRP6, BRCA1, VANGL1, VANGL2, ZIC3, PAX7
14	hearing/vestibular/ear phenotype	MP:0005377	7.0	MSX2, FZD3, FZD6, FUZ, FOLR1, ALDH1A2
15	limbs/digits/tail phenotype	MP:0005371	6.6	NOG, PAX1, PAX9, PAX3, SCRIB, MTHFR
16	skeleton phenotype	MP:0005390	6.6	LRP6, FOXN1, ALDH1A2, ALX1, TP53, TERC
17	cardiovascular system phenotype	MP:0005385	6.6	CBS, CDH2, CD320, FOLH1, CCL2, F5
18	integument phenotype	MP:0010771	6.5	S100B, T, TP53, CBS, F2, CELSR1
19	digestive/alimentary phenotype	MP:0005381	6.4	F2, LRP6, FUZ, MSX2, T, MUT
20	cellular phenotype	MP:0005384	6.3	CBS, ALDH1A2, F2, TERC, PRICKLE1, TUBB3
21	behavior/neurological phenotype	MP:0005386	6.2	CBS, ALX1, F5, CCL2, FOLH1, FZD3
22	nervous system phenotype	MP:0003631	6.1	VANGL2, F5, F2, ALDH1A2, ALX1, TERC
23	growth/size phenotype	MP:0005378	6.0	LRP6, BRCA1, VANGL1, VANGL2, BMP4, RARB
24	vision/eye phenotype	MP:0005391	6.0	ALX1, CBS, TP53, TERC, CYP26B1, SNAI2
25	embryogenesis phenotype	MP:0005380	5.6	ZIC3, ALDH1A2, ALX1, CBS, TERC, CYP26A1
26	homeostasis/metabolism phenotype	MP:0005376	5.2	LRP6, NAT1, NAT2, BRCA1, BMP4, F5
27	mortality/aging	MP:0010768	3.0	ALDH1A2, DVL2, DVL3, DKK1, PRICKLE1, CXCL6

Articles related to neural tube defect:

(show top 50)    (show all 180)

id	Title	Authors	Year	Affiliating Genes
1	Prevalence of cystathionine beta synthase gene mutati on 852Ins68 as a possible risk for neural tube defects in eastern India. (22002135)	Saxena A.K.... Pandey L.K.	2011	CBS
2	Single nucleotide polymorphisms of the maternal Msx2 gene and their association with fetal neural tube defects in Han ethnic group i n Shanxi Province, China. (21362336)	Guo L.... Xie J.	2011	MSX2
3	Association between a 45-bp 3'untranslated insertion/ deletion polymorphism in exon 8 of UCP2 gene and neural tube defects in a high- risk area of China. (21266666)	Wang J.... Zhang T.	2011	UCP2
4	FZD6 is a novel gene for human neural tube defects. (22045688)	De Marco P.... Capra V.	2011	FZD6, FZD3
5	Identification and characterization of novel rare mutations in the planar cell polarity gene PRICKLE1 in human neural tube defects. (21901791)	Bosoi C.M.... Kibar Z.	2011	PRICKLE1
6	Analysis of the MTHFD1 promoter and risk of neural tube defects. (19130090)	Carroll N.... Parle-McDermott A.	2009	MTHFD1
7	The cochlea in fetuses with neural tube defects. (19664702)	Schmutzhard J.... Schrott-Fischer A.	2009	TUBB3
8	Prenatal diagnosis, fetal surgery, recurrence risk and differential diagnosis of neural tube defects. (18935990)	Chen C.P.	2008	AFP
9	Genetic and biochemical determinants of serum concentrations of monocyte chemoattractant protein-1, a potential neural tube defect risk factor. (18937353)	Lu Z.Y.... Whitehead A.S.	2008	CCL2, MTHFR
10	Neural tube defects in the sample of genetic counselling. (17602445)	JoA^ J.G.... Papp Z.	2007	AFP
11	Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6. (16126904)	Carter M.... Ross M.E.	2005	LRP6, DKK1
12	Maternal fumonisin exposure and risk for neural tube defects: mechanisms in an in vivo mouse model. (15959874)	Gelineau-van Waes J.... Riley R.T.	2005	TFPT
13	Analysis of MTHFR 1298A>C in addition to MTHFR 677C>T polymorphism as a risk factor for neural tube defects in the Turkish population. (16363341)	Boduroglu K.... Tuncbilek E.	2005	MTHFR
14	Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives. (15136147)	Inoue T.... Mikoshiba K.	2004	ZIC2, ZIC1
15	Mutation incidence in folate metabolism genes and regulatory genes in Polish families with neural tube defects. (15306729)	Gos M.... Szpecht-Potocka A.	2004	MTR, MTHFR
16	Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol. (14613966)	Cogram P.... Copp A.J.	2004	DYT10
17	Analysis of the MTHFR 1298A-->C and 677C-->T polymorphisms as risk factors for neural tube defects. (12730722)	Parle-McDermott A.... Brody L.C.	2003	MTHFR
18	Analysis of the human folate receptor beta gene for an association with neural tube defects. (12809644)	O'Leary V.B.... Brody L.C.	2003	FOLR2
19	Risk factors for neural tube defects: associations between uncoupling protein 2 polymorphisms and spina bifida. (12797456)	Volcik K.A.... Finnell R.H.	2003	UCP2
20	Lack of association between ZIC2 and ZIC3 genes and the risk of neural tube defects (NTDs) in Hispanic populations. (12522805)	Zhu H.... Hendricks K.	2003	ZIC3, ZIC2
21	C677T and A1298C MTHFR polymorphisms in the etiology of neural tube defects in Spanish population (12689549)	Gutierrez Revilla J.I.... Gracia Romero J.	2003	MTHFR
22	Prenatal screening for open neural tube defects. (12848450)	Canick J.A.... Bombard A.T.	2003	AFP
23	Gene-gene interaction between the cystathionine beta-synthase 31 base pair variable number of tandem repeats and the methylenetetrahydrofolate reductase 677C > T polymorphism on homocysteine levels and risk for neural tube defects. (12649066)	Afman L.A.... Blom H.J.	2003	CBS, MTHFR
24	The H475Y polymorphism in the glutamate carboxypeptidase II gene increases plasma folate without affecting the risk for neural tube defects in humans. (12514270)	Afman L.A.... Blom H.J.	2003	FOLH1
25	Does prenatal screening for 5,10-methylenetetrahydrofolate reductase (MTHFR) mutations in high-risk neural tube defect pregnancies make sense? (12180076)	Finnell R.H.... Volcik K.A.	2002	MTHFR
26	SNPs in the CpG island of NAP1L2: a possible link bet ween DNA methylation and neural tube defects? (12116227)	Rogner U.C.... Avner P.	2002	NAP1L2
27	A novel mutation in the gene encoding noggin is not causative in human neural tube defects. (12420790)	Bauer K.A.... Speer M.C.	2002	NOG
28	Genetic basis of neural tube defects. II. Genes correlated with folate and methionine metabolism. (12441636)	Gos M.... Szpecht-Potocka A.	2002	CBS, MTR, MTHFD1
29	Mutations of MTHFR, MTR, MTRR genes as high risk factors for neural tube defects (12810988)	Sliwerska E.... Szpecht-Potocka A.	2002	MTR, MTHFR, MTRR
30	Biochemical screening for chromosomal disorders and neural tube defects (NTD): is adjustment of maternal alpha-fetoprotein (AFP) still appropriate in insulin-dependent diabetes mellitus (IDDM)? (11360279)	Sancken U.... Bartels I.	2001	AFP
31	Methionine synthase and neural tube defects (12520968)	Zhao T.... Li Y.	2000	MTR
32	Assay precision of serum alpha fetoprotein in antenatal screening for neural tube defects and Down's syndrome. (11002446)	Wald N.J.... George L.M.	2000	AFP
33	The common C677T polymorphism in the methylenetetrahydrofolate reductase gene is associated with neural tube defects and preeclampsia (10751524)	Li K.... Li P.	2000	MTHFR
34	Linkage disequilibrium of MTHFR genotypes 677C/T-1298A/C in the German population and association studies in probands with neural tube defects(NTD). (10528242)	Stegmann K.... Koch M.C.	1999	MTHFR
35	Possible interaction of genotypes at cystathionine beta-synthase and methylenetetrahydrofolate reductase (MTHFR) in neural tube defects. NTD Collaborative Group. (10517251)	Speer M.C.... George T.M.	1999	CBS, MTHFR
36	The 'thermolabile' variant of methylenetetrahydrofolate reductase and neural tube defects: An evaluation of genetic risk and the relative importance of the genotypes of the embryo and the mother. (10090889)	Shields D.C.... Whitehead A.S.	1999	MTHFR
37	Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). (10051400)	Eddleston J.... Stanier P.	1999	PFDN2
38	Association of the 677C-->T mutation on the methylenetetrahydrofolate reductase gene in Turkish patients with neural tube defects. (10190266)	Boduroglu K.... Tuncbilek E.	1999	MTHFR
39	Human transcription factor SLUG: mutation analysis in patients with neural tube defects and identification of a missense mutation (D119E) in the Slug subfamily-defining region. (10479723)	Stegmann K.... Koch M.C.	1999	SNAI2
40	Cell kinetics of surgically induced spinal open neural tube defect in chick embryos. (9605486)	Park I.S.... Wang K.C.	1998	PCNA
41	Are common mutations of cystathionine beta-synthase involved in the aetiology of neural tube defects? (9084933)	Ramsbottom D.... Whitehead A.S.	1997	CBS
42	Changes in cell adhesion and extracellular matrix molecules in spontaneous spinal neural tube defects in avian embryos. (9181673)	Newgreen D.F.... Warren N.	1997	CDH2
43	Methionine synthase and neural tube defects. (9391898)	Morrison K.... Mariman E.	1997	MTR
44	Risk of neural tube defect-affected pregnancy is associated with a block in maternal one-carbon metabolism at the level of N-5-methyltetrahydrofolate:homocysteine methyltransferase. (9232194)	Lucock M.D.... Levene M.I.	1997	MTR
45	Is mutated MTHFR a risk factor for neural tube defects? (8596396)	Posey D.L.... Ou C.Y.	1996	MTHFR
46	PAX genes and human neural tube defects: an amino acid substitution in PAX1 in a patient with spina bifida. (8863157)	Hol F.A.... Mariman E.C.M.	1996	PAX3, PAX7, PAX9
47	A genetic defect in 5,10 methylenetetrahydrofolate reductase in neural tube defects. (8542260)	Whitehead A.S.... Scott J.M.	1995	MTHFR
48	Folic acid metabolism and mechanisms of neural tube defects. (8005024)	Scott J.M.... Kirke P.	1994	MTR
49	The methylfolate axis in neural tube defects: in vitro characterisation and clinical investigation. (7993656)	Lucock M.D.... Hartley R.	1994	MTHFR
50	Amniotic and serum alphafetoprotein in the chick embryo with neural tube defect (7692911)	Uriarte S.... Tovar J.A.	1993	AFP

Genes related to neural tube defect according to GeneCards:

(show top 50)    (show all 93)

id	Symbol	Description	Score	GeneCards Section Context
1	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.1	Summaries, Publications, Functions, UniProt Related
2	ZIC2	Zic family member 2	11.1	Publications, Summaries
3	VANGL1	vang-like 1 (van gogh, Drosophila)	11.1	Publications, Summaries
4	SNAI2	snail homolog 2 (Drosophila)	11.1	Summaries, Publications
5	MTR	5-methyltetrahydrofolate-homocysteine methyltransferase	11.1	Functions, Publications
6	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	11.1	Publications, Functions
7	T	T, brachyury homolog (mouse)	11.1	Publications, Functions
8	FOLR2	folate receptor 2 (fetal)	11.0	Publications
9	VANGL2	vang-like 2 (van gogh, Drosophila)	11.0	Publications
10	ZIC1	Zic family member 1	11.0	Publications
11	ZIC3	Zic family member 3	11.0	Publications
12	MTHFD1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	11.0	Publications
13	MARCKSL1	MARCKS-like 1	11.0	Publications
14	TCN2	transcobalamin II	11.0	Publications
15	PAX3	paired box 3	11.0	Publications
16	CBS	cystathionine-beta-synthase	11.0	Functions, Publications
17	AFP	alpha-fetoprotein	11.0	Publications
18	SHMT1	serine hydroxymethyltransferase 1 (soluble)	11.0	Publications
19	SLC19A1	solute carrier family 19 (folate transporter), member 1	11.0	Publications
20	TAGLN2	transgelin 2	11.0
21	CGB7	chorionic gonadotropin, beta polypeptide 7	11.0	Publications
22	CGB	chorionic gonadotropin, beta polypeptide	11.0	Publications
23	UCP2	uncoupling protein 2 (mitochondrial, proton carrier)	11.0	Publications
24	FUZ	fuzzy homolog (Drosophila)	11.0	Summaries
25	ACHE	acetylcholinesterase	11.0	Publications
26	BCHE	butyrylcholinesterase	11.0
27	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
28	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
29	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0
30	NAT1	N-acetyltransferase 1 (arylamine N-acetyltransferase)	11.0	UniProt Related
31	TYMS	thymidylate synthetase	11.0	Publications
32	MAB21L1	mab-21-like 1 (C. elegans)	11.0	Publications
33	NAP1L2	nucleosome assembly protein 1-like 2	11.0	Publications
34	RFC1	replication factor C (activator 1) 1, 145kDa	11.0	Publications
35	PFDN2	prefoldin subunit 2	11.0	Publications
36	PAX1	paired box 1	11.0	Publications
37	CD320	CD320 molecule	11.0	Publications
38	FOXN1	forkhead box N1	11.0	Publications
39	DCAF8	DDB1 and CUL4 associated factor 8	11.0	Publications
40	DVL3	dishevelled, dsh homolog 3 (Drosophila)	11.0	Publications
41	DVL2	dishevelled, dsh homolog 2 (Drosophila)	11.0	Publications
42	SLC19A2	solute carrier family 19 (thiamine transporter), member 2	11.0	Publications
43	CXCL6	chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)	11.0	Publications
44	CYP26A1	cytochrome P450, family 26, subfamily A, polypeptide 1	11.0	Publications
45	PAX9	paired box 9	11.0	Publications
46	CYP26B1	cytochrome P450, family 26, subfamily B, polypeptide 1	11.0	Publications
47	NOG	noggin	11.0	Publications
48	SHMT2	serine hydroxymethyltransferase 2 (mitochondrial)	11.0	Publications
49	SYNM	synemin, intermediate filament protein	11.0	Publications
50	CRABP1	cellular retinoic acid binding protein 1	11.0	Publications

Pathways related to neural tube defect according to GeneDecks:

(show all 23)

id	Pathway	Score	Top Affiliating Genes
1	Vitamin digestion and absorption20	10.5	TCN2, FOLH1, SLC19A2, SLC19A1
2	Antimetabolite Pathway - Folate Cycle, Pharmacodynamics34	10.5	TYMS, SHMT1, CBS, MTHFD1, MTR, MTHFR
3	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics34	10.5	MTRR, MTHFR, MTR, MTHFD1, CBS, SHMT1
4	Methotrexate Pathway (Cancer Cell), Pharmacodynamics34	10.4	MTR, MTRR, SLC19A1, DHFR, TYMS, SHMT1
5	Glycine, serine and threonine metabolism20	10.4	CBS, SHMT2, SHMT1, BHMT
6	Metabolism of water-soluble vitamins and cofactors38	10.4	SLC19A2, MTHFD1, SLC19A1, MTHFR
7	Factors Promoting Cardiogenesis in Vertebrates36	10.3	DVL1, FZD3, FZD6, NOG
8	Caffeine metabolism20	10.3	NAT1, NAT2, CYP1A2
9	Fluoropyrimidine Pathway, Pharmacodynamics34	10.1	TP53, MTHFR, DHFR, TYMS
10	Translation_Non-genomic (rapid) action of Androgen Receptor41	10.1	DVL2, DVL1, FZD6, FZD3, DVL3
11	Wnt Signaling Pathway37	10.1	DVL3, DVL2, DVL1, FZD6, FZD3, LRP6
12	Translation Non-genomic (rapid) action of Androgen Receptor10	10.1	DVL2, DVL1, FZD3, FZD6, DVL3
13	Human Embryonic Stem Cell Pluripotency36	10.0	PDGFRA, DVL1, BMP4, FZD6, NOG, FZD3
14	Transcription_Androgen Receptor nuclear signaling41	9.9	FZD3, DVL2, DVL3, DVL1, FZD6
15	Basal cell carcinoma20	9.8	DVL2, DVL1, TP53, FZD6, FZD3, DVL3
16	One carbon pool by folate20	9.7	DHFR, MTHFR, MTR, MTHFD1, MTHFD1L, ALDH1L1
17	Transcription Androgen Receptor nuclear signaling10	9.7	FZD3, DVL3, DVL2, FZD6, DVL1
18	Selected targets of Oct-3/410	9.6	CGB7, TP53, CGB, DKK1, PDGFRA, T
19	Wnt / Hedgehog / Notch3	9.6	SNAI2, DVL3, DVL2, AFP, FZD6, SCRIB
20	Wnt signaling pathway20	9.5	PRICKLE1, DKK1, DVL3, DVL1, TP53, FZD6
21	Pathways in cancer20	9.4	PDGFRA, DVL3, FZD3, FZD6, BMP4, TP53
22	Metabolic pathways20	9.0	BHMT, CBS, ALDH1A2, DHFR, TYMS, SHMT2
23	Molecular Mechanisms of Cancer36	8.5	CXCL6, PDGFRA, BRCA1, BMP4, RARB, FZD3

Compounds related to neural tube defect according to GeneDecks:

(show top 50)    (show all 148)

id	Compound	Score	Top Affiliating Genes
1	b vitamins32	10.7	MTRR, MTHFR, MTR, CBS, TYMS, SHMT1
2	5,10-methenyltetrahydrofolate32	10.6	SHMT2, CBS, MTHFD1, MTR, MTHFR
3	oestriol32	10.6	CGB7, AFP, CGA, CGB, CGB5
4	methylcobalamin32 18	11.6	MTR, MTHFR, MTRR, TCN1, CBS, MUT
5	methylmalonic acid32 18	11.6	MTRR, TCN2, TCN1, CBS, MTR, MUT
6	cyanocobalamin34 9 18 9	13.6	TCN2, TCN1, MTHFR, MTR, MTRR, MUT
7	hydroxocobalamin32 9 9	12.6	TCN2, TCN1, MTR, MTHFR, MTRR, MUT
8	cobalamin32 18	11.5	MUT, MTR, MTRR, MTHFR, TCN2, TCN1
9	5-methyltetrahydrofolate32 9 9	12.4	FOLR2, F5, FOLR1, SLC19A1, MTR, MTHFR
10	cystathionine32	10.4	TCN2, CBS, F5, MTHFD1, MTR, MTHFR
11	purine32 18	11.4	SHMT1, MTR, MTHFR, MTHFD1, CBS, TYMS
12	betaine32 18	11.3	MTR, MTHFR, MTRR, BHMT, CBS
13	folic acid34 9 18 9	13.3	SLC19A1, MTHFR, FOLR1, FOLR2, SLC19A2, DHFR
14	leucovorin32 34 9 9	13.3	FOLR1, CGB, SHMT2, CGB5, DHFR, TYMS
15	vitamin b632	10.2	MTHFD1, MTR, MTHFR, BHMT, TCN2, CBS
16	dihydrofolate32	10.2	TYMS, SHMT1, FOLR1, MTR, MTHFR, SLC19A1
17	10-formyltetrahydrofolate32	10.0	ALDH1L1, DHFR, MTR, SLC19A1, MTHFD1, MTHFR
18	methionine32	10.0	SLC25A13, FOLR1, TCN2, CRABP2, FOLR2, S100B
19	tetrahydrofolate32	10.0	MTRR, MTHFR, MTR, ALDH1L1, SHMT1, SHMT2
20	Tetrahydrofolic acid9 18 9	11.8	DHFR, MTR, SHMT2, SHMT1, MTHFD1L, MTHFR
21	tomudex32	9.8	SLC19A1, DHFR, TYMS, TP53, FOLR1
22	etoposide32 42 9 9	12.6	TERC, CGA, PCNA, S100B, AFP, CGB
23	dopamine32 9 18 9	12.3	CGB5, CD40LG, NOG, CGA, ACHE, S100B
24	bleomycin32 9 9	11.3	AFP, TP53, BRCA1, CGB, CGB7, CCL2
25	thymidylate32	9.2	PCNA, BRCA1, TYMS, DHFR, SLC19A1, MTR
26	doxorubicin32 34 9 9	12.2	BRCA1, FOLH1, FOLR1, TP53, TERC, AFP
27	h2o232	9.1	CGA, CGB5, CBS, DVL1, TFPT, DHFR
28	vitamin b1232	9.0	FOLH1, CCL2, F5, CBS, TYMS, TCN1
29	homocysteine32 18	10.0	CBS, SLC19A1, TCN2, TCN1, SHMT1, NAT1
30	aspartate32	8.9	SHMT2, S100B, F2, F5, PCNA, SLC25A13
31	methotrexate32 34 42 9 9	12.9	PCNA, NAT2, BRCA1, MTRR, MTHFR, MTR
32	lactate32	8.9	CD40LG, TFPT, DHFR, CGB, CGA, S100B
33	hydroxyurea32 9 9	10.8	F2, TP53, PDGFRA, TYMS, BRCA1, PCNA
34	glutamate32	8.8	CDH2, MTR, MTHFR, MTRR, FOLH1, CBS
35	creatinine32	8.7	CCL2, AFP, TCN2, TYMS, F2, CD40LG
36	5fluorouracil32	8.6	MTHFR, PCNA, AFP, FOLH1, SLC19A1, DHFR
37	progesterone32 42 9 18 9	12.5	CGB, TERC, CDH2, CGB7, CGB5, CGA
38	paclitaxel32 34 9 9	11.5	AFP, S100B, DHFR, TP53, SLC19A1, BRCA1
39	alanine32	8.1	BRCA1, PCNA, RFC1, CGB, MTHFR, MTRR
40	oligonucleotide32	8.0	BMP4, RARB, PAX7, NAT1, NAT2, BRCA1
41	cisplatin32 34 9 9	11.0	CGB5, CGB, CGA, MTR, RARB, MTHFR
42	folate32	8.0	MTRR, SHMT2, TYMS, TCN2, DHFR, SLC19A2
43	cysteine32	7.8	CD40LG, FOLH1, NOG, DHFR, TYMS, RARB
44	arginine32	7.7	SLC19A1, CGB5, F5, CCL2, CD40LG, CGA
45	testosterone32 9 18 9	10.7	CYP1A2, CGB, CGA, LEPR, S100B, MTHFR
46	tamoxifen32 34 9 9	10.7	TP53, DYT10, TERC, CYP1A2, CRABP2, TYMS
47	vegf32	7.0	CXCL6, AFP, CCL2, PCNA, CD40LG, TYMS
48	estrogen32	6.7	F2, PCNA, NAT1, NAT2, AFP, CD40LG
49	retinoic acid32 42 18	8.4	CRABP1, F5, ALDH1A2, TUBB3, TP53, DYT10
50	serine32	6.2	AFP, SLC19A1, CXCL6, DHFR, TFPT, FOLR1

Cellular components related to neural tube defect according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	6.8	PCNA, ALDH1A2, TUBB3, TRIM26, TP53, SNAI2

Biological processes related to neural tube defect according to GeneDecks:

(show all 24)

id	Name	GO ID	Score	Top Affiliating Genes
1	methionine biosynthetic process	GO:009086	10.7	BHMT, MTHFR, MTHFD1, MTRR
2	folic acid metabolic process	GO:046655	10.6	MTHFR, SLC19A1, FOLR1, SHMT1, MTHFD1
3	homocysteine metabolic process	GO:050667	10.6	MTHFR, MUT, CBS, MTR
4	folic acid transport	GO:015884	10.6	FOLR1, FOLR2, SLC19A1, SLC19A2
5	water-soluble vitamin metabolic process	GO:006767	10.5	SHMT1, MTHFR, MTHFD1, SLC19A1, SLC19A2
6	tetrahydrofolate interconversion	GO:035999	10.5	SHMT1, SHMT2, MTHFR, MTHFD1L, MTHFD1
7	vitamin metabolic process	GO:006766	10.5	SLC19A1, SHMT1, CYP26B1, CYP26A1, MTHFR, MTHFD1
8	non-canonical Wnt receptor signaling pathway	GO:035567	10.5	DVL3, DVL2, FZD6
9	Wnt receptor signaling pathway, planar cell polarity pathway	GO:060071	10.5	DVL2, DVL1, DVL3, FZD6
10	hair follicle development	GO:001942	10.4	FZD3, FZD6, VANGL2, FUZ, DKK1
11	canonical Wnt receptor signaling pathway	GO:060070	10.2	FZD3, DVL1, T, DVL3, DVL2, LRP6
12	negative regulation of canonical Wnt receptor signaling pathway	GO:090090	10.2	SNAI2, CDH2, FZD6, DKK1, NOG, PRICKLE1
13	response to folic acid	GO:051593	10.1	BCHE, CBS, LRP6
14	embryonic forelimb morphogenesis	GO:035115	10.1	CRABP2, LRP6, MSX2, ALDH1A2
15	anterior/posterior pattern specification	GO:009952	10.0	MSX2, ZIC3, ALX1, VANGL2, ALDH1A2, CYP26A1
16	embryonic hindlimb morphogenesis	GO:035116	9.9	BMP4, LRP6, RARB, MSX2
17	xenobiotic metabolic process	GO:006805	9.8	NAT1, NAT2, MTR, CYP1A2, CYP26B1, CYP26A1
18	negative regulation of chondrocyte differentiation	GO:032331	9.8	RARB, BMP4, SNAI2
19	establishment of planar polarity	GO:001736	9.7	CELSR1, FUZ, VANGL2
20	small molecule metabolic process	GO:044281	9.3	CGA, CYP1A2, CYP26A1, CYP26B1, SHMT1, MTHFD1
21	positive regulation of transcription, DNA-dependent	GO:045893	9.0	LRP6, DVL3, DVL2, DVL1, ZIC1, ALX1
22	positive regulation of apoptotic process	GO:043065	8.6	LRP6, BMP4, RARB, SCRIB, MSX2, ALDH1A2
23	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.6	NOG, TP53, ALX1, CGA, ZIC3, LRP6
24	neural tube closure	GO:001843	8.6	ALX1, PRICKLE1, DVL2, NOG, FUZ, CELSR1

Molecular functions related to neural tube defect according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	folic acid binding	GO:005542	10.3	SLC19A2, MTR, FOLR1, FOLR2, SLC19A1
2	cobalamin binding	GO:031419	10.3	MTR, MUT, TCN2, CD320
3	retinal binding	GO:016918	10.1	CRABP2, CRABP1, ALDH1A2
4	modified amino acid binding	GO:072341	10.0	MTHFR, MUT, CBS
5	frizzled binding	GO:005109	9.9	DVL3, DVL2, DVL1, LRP6