NTDS
MCID: NRL016
MIFTS: 69

Neural Tube Defects (NTDS) malady

Genetic diseases, Rare diseases categories

Summaries for Neural Tube Defects

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MedlinePlus:33 Neural tube defects are birth defects of the brain, spine, or spinal cord. they happen in the first month of pregnancy, often before a woman even knows that she is pregnant. the two most common neural tube defects are spina bifida and anencephaly. in spina bifida, the fetal spinal column doesn't close completely. there is usually nerve damage that causes at least some paralysis of the legs. in anencephaly, most of the brain and skull do not develop. babies with anencephaly are either stillborn or die shortly after birth. another type of defect, chiari malformation, causes the brain tissue to extend into the spinal canal. the exact causes of neural tube defects aren't known. you're at greater risk of having an infant with a neural tube defect if you are obese have poorly controlled diabetes take certain antiseizure medicines getting enough folic acid, a type of b vitamin, before and during pregnancy prevents most neural tube defects. neural tube defects are usually diagnosed before the infant is born, through lab or imaging tests. there is no cure for neural tube defects. the nerve damage and loss of function that are present at birth are usually permanent. however, a variety of treatments can sometimes prevent further damage and help with complications. nih: national institute of child health and human development

MalaCards based summary: Neural Tube Defects, also known as dysraphism, is related to anencephaly and craniorachischisis, and has symptoms including autosomal dominant inheritance, urinary incontinence and hydrocephalus. An important gene associated with Neural Tube Defects is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are Folate Metabolism and Folate-Alcohol and Cancer Pathway. The compounds "vitamin b-complex, plain" and 5-Methyltetrahydrofolic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are hearing/vestibular/ear and renal/urinary system.

NIH Rare Diseases:42 Neural tube defects (ntds) refers to a group of abnormalities resulting from abnormal development of the brain, spine and/or spinal column. during the development of an affected embryo, a structure called the neural tube does not close completely as it should, resulting in a hole somewhere along the spinal column. specific examples of types of ntds include spina bifida, anencephaly, and encephalocele. symptoms vary depending on the type of ntd present but often include various forms of physical and/or mental disabilities. many affected individuals do not survive. the exact cause of ntds is not known but is thought to involve both genetic and nongenetic factors. getting enough folic acid before and during pregnancy can reduce the risk of some ntds. treatment depends on the severity and type of defect and may include surgery. last updated: 11/6/2013

OMIM:46 Neural tube defects are the second most common type of birth defect after congenital heart defects. The 2 most common... (182940) more...

CDC:4 Neglected Tropical Diseases (NTDs) are a group of parasitic and bacterial diseases that cause substantial illness for more than one billion people globally. Affecting the world's poorest people, NTDs impair physical and cognitive development, contribute to mother and child illness and death, make it difficult to farm or earn a living, and limit productivity in the workplace. As a result, NTDs trap the poor in a cycle of poverty and disease.

Wikipedia:64 Neural tube defects (NTDs) are one of the most common birth defects, affecting over 300,000 births... more...

Description from OMIM:46 601634

Aliases & Classifications for Neural Tube Defects

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Neural Tube Defects, Aliases & Descriptions:

Name: Neural Tube Defects 31 10 42 21 23 46 44 33
Dysraphism 42
 
Ntds 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases


Related Diseases for Neural Tube Defects

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Diseases related to Neural Tube Defects via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 137)
idRelated DiseaseScoreTop Affiliating Genes
1anencephaly31.8AFP, MTHFR
2craniorachischisis31.3VANGL2
3myelomeningocele31.3MTHFR, CBS
4neural tube defects, folate-sensitive31.2MTRR, MTR
5down syndrome31.1AFP, CBS, MTHFR, MTRR, MTR, SLC19A1
6cleft lip31.0MTHFR, MTRR, MTR, SLC19A1
7gastroschisis30.9AFP
8spina bifida30.9FUZ, SLC19A1, ZIC2, ZIC1, MTR, MTRR
9vitamin b12 deficiency30.9TCN2, MTHFR, MTR
10glucose intolerance30.7TCN2, MTR
11homocystinuria30.6MTR, MTRR, MTHFR, TCN2, CBS
12hyperhomocysteinemia30.6CBS, MTHFR, MTRR, MTR, SLC19A1
13vascular disease30.6CBS, MTHFR, MTRR, MTR, SLC19A1
14occult spinal dysraphism11.0
15encephalocele10.6
16caudal regression syndrome10.5VANGL1
17strabismus10.5VANGL2
18exencephaly10.5
19iniencephaly10.5
20omphalocele10.5
21homocysteinemia due to mthfr deficiency10.5MTHFR, MTR
22megaloblastic anemia10.5MTR, TCN2
23disorders of intracellular cobalamin metabolism10.5MTRR, MTR
24hydrocephalus10.5
25obesity10.5
26orofacial cleft10.5
27peripheral vascular disease10.4MTHFR, CBS
28congenital heart disease10.4MTHFR, ZIC3
29portal vein thrombosis10.4MTHFR, AFP
30patau syndrome10.4ZIC2, AFP
31homocysteinemia10.4MTR, MTHFR, CBS
32hyperopia10.4VANGL2, VANGL1
33placental abruption10.4AFP, MTHFR
34cerebrovascular disease10.4MTR, MTHFR, CBS
35meningocele10.4
36meckel syndrome10.4
37diabetic embryopathy10.4
38cataract-congenital heart disease-neural tube defect syndrome10.4
39thromboembolism10.4CBS, MTHFR, MTR
40venous thrombosis10.4CBS, MTHFR, MTR
41lipoma10.4
42methylmalonic acidemia10.4MTR, TCN2
43acute lymphoblastic leukemia, childhood10.4SLC19A1, MTHFR, MTHFD1
44pulmonary embolism10.4CBS, MTHFR
45cleft palate10.4MTHFR, MTR, SNAI2, SLC19A1
46folic acid deficiency anemia10.3SLC19A1, MTR, MTHFR, CBS
47schizophrenia10.3
48neuronitis10.3
49hyperglycemia10.3
50lipomyelomeningocele10.3

Graphical network of the top 20 diseases related to Neural Tube Defects:



Diseases related to neural tube defects

Symptoms for Neural Tube Defects

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Symptoms by clinical synopsis from OMIM:

182940

Clinical features from OMIM:

601634,182940

HPO human phenotypes related to Neural Tube Defects:

(show all 9)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 urinary incontinence HP:0000020
3 hydrocephalus HP:0000238
4 multiple lipomas HP:0001012
5 anencephaly HP:0002323
6 myelomeningocele HP:0002475
7 spina bifida occulta HP:0003298
8 asymmetry of spinal facet joints HP:0008482
9 abnormality of metabolism/homeostasis HP:0001939

Drugs & Therapeutics for Neural Tube Defects

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Drug clinical trials:

Search ClinicalTrials for Neural Tube Defects

Search NIH Clinical Center for Neural Tube Defects

Genetic Tests for Neural Tube Defects

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Genetic tests related to Neural Tube Defects:

id Genetic test Affiliating Genes
1 Neural Tube Defect21 23

Anatomical Context for Neural Tube Defects

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MalaCards organs/tissues related to Neural Tube Defects:

32
Brain, Spinal cord, Heart, Testes, Skin, Placenta, Bone marrow, Bone, Monocytes

Animal Models for Neural Tube Defects or affiliated genes

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MGI Mouse Phenotypes related to Neural Tube Defects:

36 (show all 19)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.5FUZ, SCRIB, VANGL2, VANGL1, CELSR1, ZIC3
2MP:00053679.3DACT1, T, SCRIB, CBS, VANGL2, SLC19A1
3MP:00053889.2FUZ, SCRIB, CBS, VANGL2, VANGL1, CELSR1
4MP:00107719.2T, CBS, CELSR1, MTHFR, SNAI2, ZIC2
5MP:00053819.2DACT1, FUZ, T, SCRIB, VANGL2, SNAI2
6MP:00053829.1FUZ, T, CBS, VANGL2, CELSR1, SNAI2
7MP:00053919.1FUZ, SCRIB, CBS, VANGL2, CELSR1, MTHFR
8MP:00053979.0VANGL2, CELSR1, MTHFD1, SNAI2, ZIC3, SLC19A1
9MP:00053798.9FUZ, AFP, SCRIB, CBS, SNAI2, SLC19A1
10MP:00053858.9DACT1, FUZ, T, CBS, VANGL2, VANGL1
11MP:00053908.9DACT1, FUZ, T, VANGL2, CELSR1, MTHFR
12MP:00053898.7SCRIB, AFP, T, DACT1, CBS, VANGL2
13MP:00053868.6T, AFP, CBS, VANGL2, CELSR1, SNAI2
14MP:00053718.5ALX1, DACT1, FUZ, T, SCRIB, CBS
15MP:00036318.4VANGL1, VANGL2, SCRIB, T, FUZ, DACT1
16MP:00053768.3VANGL2, CBS, AFP, T, FUZ, CELSR1
17MP:00053808.2VANGL2, CBS, SCRIB, T, FUZ, DACT1
18MP:00053788.0VANGL1, VANGL2, CBS, SCRIB, T, DACT1
19MP:00107687.4VANGL1, VANGL2, CBS, SCRIB, AFP, T

Publications for Neural Tube Defects

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Articles related to Neural Tube Defects:

(show top 50)    (show all 710)
idTitleAuthorsYear
1
DNA methylation aberrations rather than polymorphisms of FZD3 gene increase the risk of spina bifida in a high-risk region for neural tube defects. (25131656)
2014
2
Association between VANGL1 Gene Polymorphisms and Neural Tube Defects. (24407469)
2014
3
Neural tube defects, folic acid and methylation. (24048206)
2013
4
Novel mutations in Lrp6 orthologs in mouse and human neural tube defects affect a highly dosage-sensitive Wnt non-canonical planar cell polarity pathway. (24203697)
2013
5
Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects. (22892949)
2013
6
Is LMNB1 a susceptibility gene for neural tube defects in humans? (23733478)
2013
7
The amniotic fluid as a source of neural stem cells in the setting of experimental neural tube defects. (22957979)
2013
8
Knowledge and periconceptional use of folic acid for the prevention of neural tube defects in ethnic communities in the United Kingdom: systematic review and meta-analysis. (23873812)
2013
9
A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study. (23059057)
2012
10
Multiple neural tube defects in a child: A rare developmental anomaly. (23372964)
2012
11
Standardized Procedural Practices of the Ontario Prenatal Screening Program for aneuploidies and open neural tube defects. (22732525)
2012
12
Serum ischemia modified albumin levels in pregnancies with neural tube defects. (22324268)
2012
13
Spinal neural tube defects in Lagos University Teaching Hospital, Nigeria. (23175875)
2012
14
Association of selected persistent organic pollutants in the placenta with the risk of neural tube defects. (21768370)
2011
15
Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans. (21840926)
2011
16
Policy statement on folic acid and neural tube defects. (21552133)
2011
17
Importance of including all pregnancy outcomes to reduce bias in epidemiologic studies of neural tube defects--Texas, 1999 to 2005. (21290567)
2011
18
The emerging role of epigenetic mechanisms in the etiology of neural tube defects. (21613818)
2011
19
Gender-dependent differences in the incidence of ochratoxin A-induced neural tube defects in the Pdn/Pdn mouse. (20201966)
2010
20
Neural tube defects in Australia: trends in encephaloceles and other neural tube defects before and after promotion of folic acid supplementation and voluntary food fortification. (19180646)
2009
21
Recent perspectives on the genetic background of neural tube defects with special regard to iniencephaly. (19379086)
2009
22
Insights into metabolic mechanisms underlying folate-responsive neural tube defects: a minireview. (19180567)
2009
23
Reproductive and sphingolipid metabolic effects of fumonisin B(1) and its alkaline hydrolysis product in LM/Bc mice: hydrolyzed fumonisin B(1) did not cause neural tube defects. (19783636)
2009
24
Neural tube defects and herbal medicines containing lead: a possible relationship. (19028023)
2009
25
Thrombophilia-associated gene mutations in women with pregnancies complicated by fetal neural tube defects. (18068170)
2008
26
Syndromes, disorders and maternal risk factors associated with neural tube defects (IV). (18603497)
2008
27
The hair collar sign as a marker for neural tube defects. (17461809)
2007
28
Health literacy and patient understanding of screening tests for aneuploidy and neural tube defects. (17345585)
2007
29
Vitamin B12 and the risk of neural tube defects in a folic-acid-fortified population. (17474166)
2007
30
Reduced folate carrier gene is a risk factor for neural tube defects in a Chinese population. (15799025)
2005
31
Maternal diabetes and neural tube defects: prenatal diagnosis of lumbosacral myelomeningocele, ventriculomegaly, Arnold-Chiari malformation and foot deformities in a pregnancy with poor maternal metabolic control, and review of the literature. (16259331)
2005
32
Haplotype-dependent binding of nuclear proteins to the promoter of the neural tube defects-associated platelet-derived growth factor alpha-receptor gene. (16126374)
2005
33
Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population. (15060097)
2004
34
Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family. (15456783)
2004
35
Promoter haplotype combinations for the human PDGFRA gene are associated with risk of neural tube defects. (14741194)
2004
36
Mutation incidence in folate metabolism genes and regulatory genes in Polish families with neural tube defects. (15306729)
2004
37
Single nucleotide polymorphisms in the transcobalamin gene: relationship with transcobalamin concentrations and risk for neural tube defects. (12107818)
2002
38
Human T and risk for neural tube defects. (11897834)
2002
39
A novel mutation in the gene encoding noggin is not causative in human neural tube defects. (12420790)
2002
40
Rudimentary meningocele: remnant of a neural tube defect? (11176660)
2001
41
Neural tube defects in the Asir Region of Saudi Arabia. (17264584)
2001
42
Multicentric study of efficacy of periconceptional folic acid containing vitamin supplementation in prevention of open neural tube defects from India. (11247198)
2000
43
Heterotaxy-neural tube defect and holoprosencephaly occuring independently in two sib fetuses. (10340655)
1999
44
Molecular genetic analysis of human folate receptors in neural tube defects. (10234517)
1999
45
Methionine synthase: high-resolution mapping of the human gene and evaluation as a candidate locus for neural tube defects. (10444343)
1999
46
Neurofibromin deficiency in mice causes exencephaly and is a modifier for Splotch neural tube defects. (10419687)
1999
47
Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). (10051400)
1999
48
Association of the 677C-->T mutation on the methylenetetrahydrofolate reductase gene in Turkish patients with neural tube defects. (10190266)
1999
49
Identical twins with Weissenbacher-ZweymA1ller syndrome and neural tube defect. (8456835)
1993
50
Amniotic fluid cholinesterase of valproate-induced exencephaly in the mouse: an animal model for prenatal diagnosis of neural tube defects. (3142446)
1988

Variations for Neural Tube Defects

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UniProtKB/Swiss-Prot genetic disease variations for Neural Tube Defects:

63 (show all 12)
id Symbol AA change Variation ID SNP ID
1CELSR1p.Ala773ValVAR_067213rs12170597
2CELSR1p.Arg2438GlnVAR_067215rs199688538
3CELSR1p.Ser2964LeuVAR_067217rs6008777
4CELSR1p.Pro2983AlaVAR_067218rs61741871
5DACT1p.Asn356LysVAR_068429
6SCRIBp.Pro454SerVAR_067219
7SCRIBp.Arg1535GlnVAR_067220
8VANGL1p.Arg274GlnVAR_035210
9VANGL1p.Met328ThrVAR_035211
10VANGL2p.Ser84PheVAR_067221
11VANGL2p.Arg353CysVAR_067222
12VANGL2p.Phe437SerVAR_067223

Clinvar genetic disease variations for Neural Tube Defects:

7
id Gene Name Type Significance SNP ID Assembly Location
1VANGL1NM_138959.2(VANGL1): c.821G> A (p.Arg274Gln)single nucleotide variantPathogenicrs121918219GRCh37Chr 1, 116224993: 116224993
2VANGL1NM_138959.2(VANGL1): c.983T> C (p.Met328Thr)single nucleotide variantPathogenicrs121918220GRCh37Chr 1, 116226601: 116226601
3FUZNM_025129.4(FUZ): c.115C> T (p.Pro39Ser)single nucleotide variantPathogenicrs387907204GRCh37Chr 19, 50315990: 50315990
4FUZNM_025129.4(FUZ): c.1060G> T (p.Asp354Tyr)single nucleotide variantPathogenicrs139365610GRCh37Chr 19, 50310605: 50310605
5FUZFUZZY, ARG404GLUsingle nucleotide variantPathogenic
6VANGL2NM_020335.2(VANGL2): c.1057C> T (p.Arg353Cys)single nucleotide variantPathogenicrs267607167GRCh37Chr 1, 160390961: 160390961
7VANGL2NM_020335.2(VANGL2): c.1310T> C (p.Phe437Ser)single nucleotide variantPathogenicrs267607168GRCh37Chr 1, 160394912: 160394912

Expression for genes affiliated with Neural Tube Defects

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Neural Tube Defects patients vs. healthy controls: 31 (show all 400)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1DDX3YDEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linkedAmnion-8.640.000
2RPS4Y1ribosomal protein S4, Y-linked 1Amnion-7.410.000
3EIF1AYeukaryotic translation initiation factor 1A, Y-linkedAmnion-7.250.000
4GRIA2glutamate receptor, ionotropic, AMPA 2Amnion+5.600.000
5CNTN1contactin 1Amnion+4.720.005
6THBS1thrombospondin 1Amnion-4.680.000
7FABP7fatty acid binding protein 7, brainAmnion+4.600.003
8PMP2peripheral myelin protein 2Amnion+4.490.024
9CADM2cell adhesion molecule 2Amnion+4.330.010
10GPM6Aglycoprotein M6AAmnion+4.280.006
11SCG3secretogranin IIIAmnion+4.200.002
12NLGN4Xneuroligin 4, X-linkedAmnion+4.190.012
13PPP1R3Fprotein phosphatase 1, regulatory subunit 3FAmnion+4.180.000
14SLC1A6solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6Amnion-4.170.010
15POU2F2POU class 2 homeobox 2Amnion+4.170.000
16OVOL1ovo-like zinc finger 1Amnion-4.150.000
17NRTNneurturinAmnion-4.130.016
18KRT24keratin 24Amnion-4.120.000
19GPM6Bglycoprotein M6BAmnion+4.010.039
20LHFPL3lipoma HMGIC fusion partner-like 3Amnion+4.010.012
21TXLNG2Ptaxilin gamma 2, pseudogeneAmnion-3.960.003
22NKX2-2NK2 homeobox 2Amnion+3.950.009
23NKX2-3NK2 homeobox 3Amnion-3.920.000
24WSCD1WSC domain containing 1Amnion+3.900.003
25LPHN3latrophilin 3Amnion+3.830.014
26MXD1MAX dimerization protein 1Amnion-3.830.015
27AASSaminoadipate-semialdehyde synthaseAmnion+3.790.001
28IZUMO1izumo sperm-egg fusion 1Amnion+3.790.001
29SH3GL2SH3-domain GRB2-like 2Amnion+3.790.014
30AP1S3adaptor-related protein complex 1, sigma 3 subunitAmnion-3.780.000
31ETNPPLethanolamine-phosphate phospho-lyaseAmnion-3.730.005
32ORF1uncharacterized protein, clone pT-Adv JuaX22Amnion+3.710.007
33ZNF428zinc finger protein 428Amnion+3.700.002
34KANK4KN motif and ankyrin repeat domains 4Amnion-3.690.002
35KCNC2potassium voltage-gated channel, Shaw-related subfamily, member 2Amnion-3.670.031
36ZIC2Zic family member 2Amnion+3.670.043
37ZFYzinc finger protein, Y-linkedAmnion-3.670.005
38SLC7A2solute carrier family 7 (cationic amino acid transporter, y+ system), member 2Amnion-3.660.023
39CD36CD36 molecule (thrombospondin receptor)Amnion+3.650.014
40ADSSL1adenylosuccinate synthase like 1Amnion+3.650.025
41CECR9cat eye syndrome chromosome region, candidate 9 (non-protein coding)Amnion+3.640.004
42NXPH1neurexophilin 1Amnion+3.640.041
43MFAP5microfibrillar associated protein 5Amnion-3.610.004
44AUTS2autism susceptibility candidate 2Amnion+3.590.012
45KCTD7potassium channel tetramerization domain containing 7Amnion-3.590.000
46ASCL1achaete-scute family bHLH transcription factor 1Amnion+3.590.014
47MUC15mucin 15, cell surface associatedAmnion-3.530.043
48MUSTN1musculoskeletal, embryonic nuclear protein 1Amnion+3.520.007
49MYT1myelin transcription factor 1Amnion+3.520.002
50DNAJC24DnaJ (Hsp40) homolog, subfamily C, member 24Amnion+3.510.013
51C2orf80chromosome 2 open reading frame 80Amnion+3.500.012
52CRMP1collapsin response mediator protein 1Amnion+3.490.004
53TRIM9tripartite motif containing 9Amnion+3.480.017
54GPX8glutathione peroxidase 8 (putative)Amnion-3.470.003
55AKNAAT-hook transcription factorAmnion+3.450.005
56PTENphosphatase and tensin homologAmnion+3.450.019
57CACUL1CDK2-associated, cullin domain 1Amnion+3.440.001
58CACNA1Dcalcium channel, voltage-dependent, L type, alpha 1D subunitAmnion+3.430.006
59ARHGEF28Rho guanine nucleotide exchange factor (GEF) 28Amnion-3.400.000
60PDZRN3PDZ domain containing ring finger 3Amnion-3.400.026
61ZFYVE16zinc finger, FYVE domain containing 16Amnion+3.380.032
62LRRTM2leucine rich repeat transmembrane neuronal 2Amnion+3.370.014
63FAM161Afamily with sequence similarity 161, member AAmnion+3.360.002
64CAB39Lcalcium binding protein 39-likeAmnion-3.360.023
65MYSM1Myb-like, SWIRM and MPN domains 1Amnion-3.350.007
66EDN1endothelin 1Amnion-3.340.001
67LRRIQ1leucine-rich repeats and IQ motif containing 1Amnion+3.340.008
68PCDHB3protocadherin beta 3Amnion+3.340.003
69MSH3mutS homolog 3Amnion+3.330.026
70CHD9chromodomain helicase DNA binding protein 9Amnion+3.330.018
71KRT40keratin 40Amnion-3.330.001
72AOX1aldehyde oxidase 1Amnion-3.320.007
73BAHCC1BAH domain and coiled-coil containing 1Amnion+3.320.001
74LOC645321uncharacterized LOC645321Amnion+3.300.000
75HUS1BHUS1 checkpoint homolog b (S. pombe)Amnion+3.300.004
76GFAPglial fibrillary acidic proteinAmnion+3.290.022
77DHFRdihydrofolate reductaseAmnion+3.290.027
78STMN2stathmin 2Amnion+3.290.047
79OLIG1oligodendrocyte transcription factor 1Amnion+3.280.050
80LINC00597long intergenic non-protein coding RNA 597Amnion+3.280.041
81KIAA1432KIAA1432Amnion-3.280.001
82SERPINB13serpin peptidase inhibitor, clade B (ovalbumin), member 13Amnion-3.270.001
83DNAH9dynein, axonemal, heavy chain 9Amnion+3.260.006
84KCNQ4potassium voltage-gated channel, KQT-like subfamily, member 4Amnion+3.260.012
85GARTphosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetaseAmnion+3.260.011
86EPHX1epoxide hydrolase 1, microsomal (xenobiotic)Amnion+3.250.000
87GCC1GRIP and coiled-coil domain containing 1Amnion+3.240.012
88APBA2amyloid beta (A4) precursor protein-binding, family A, member 2Amnion+3.240.006
89GJB6gap junction protein, beta 6, 30kDaAmnion-3.230.021
90OR5I1olfactory receptor, family 5, subfamily I, member 1Amnion+3.220.002
91PLEKHB2pleckstrin homology domain containing, family B (evectins) member 2Amnion+3.220.002
92ITSN1intersectin 1 (SH3 domain protein)Amnion+3.220.009
93CD99P1CD99 molecule pseudogene 1Amnion-3.220.001
94ZNF556zinc finger protein 556Amnion-3.220.024
95LRTM2leucine-rich repeats and transmembrane domains 2Amnion+3.210.015
96IGFBP3insulin-like growth factor binding protein 3Amnion-3.210.012
97HOXD9homeobox D9Amnion+3.200.001
98NFASCneurofascinAmnion+3.200.029
99OLIG2oligodendrocyte lineage transcription factor 2Amnion+3.190.007
100LRRC16Bleucine rich repeat containing 16BAmnion+3.190.020
101KDM5Dlysine (K)-specific demethylase 5DAmnion-3.190.003
102CRATcarnitine O-acetyltransferaseAmnion+3.180.001
103UVSSAUV-stimulated scaffold protein AAmnion+3.180.006
104SOX1SRY (sex determining region Y)-box 1Amnion+3.180.013
105ZNF555zinc finger protein 555Amnion-3.170.034
106RGS9BPregulator of G protein signaling 9 binding proteinAmnion-3.170.001
107ACTR3CARP3 actin-related protein 3 homolog C (yeast)Amnion-3.170.000
108ERC2ELKS/RAB6-interacting/CAST family member 2Amnion+3.170.018
109GPRC5BG protein-coupled receptor, class C, group 5, member BAmnion+3.170.022
110NTRK2neurotrophic tyrosine kinase, receptor, type 2Amnion+3.160.018
111ZNF318zinc finger protein 318Amnion+3.160.003
112PPP1R1Aprotein phosphatase 1, regulatory (inhibitor) subunit 1AAmnion+3.160.012
113TMEM37transmembrane protein 37Amnion+3.150.034
114GRIK2glutamate receptor, ionotropic, kainate 2Amnion+3.150.010
115EMX2empty spiracles homeobox 2Amnion-3.150.009
116SDSserine dehydrataseAmnion+3.150.002
117PDGFCplatelet derived growth factor CAmnion+3.150.011
118GRIN2Dglutamate receptor, ionotropic, N-methyl D-aspartate 2DAmnion+3.150.001
119FAM120AOSfamily with sequence similarity 120A opposite strandAmnion+3.140.001
120C14orf180chromosome 14 open reading frame 180Amnion+3.130.031
121CDC45cell division cycle 45Amnion+3.120.023
122DUSP26dual specificity phosphatase 26 (putative)Amnion+3.120.037
123GPR39G protein-coupled receptor 39Amnion-3.110.043
124ARCactivity-regulated cytoskeleton-associated proteinAmnion+3.110.031
125SOS2son of sevenless homolog 2 (Drosophila)Amnion-3.110.003
126SYT7synaptotagmin VIIAmnion+3.100.049
127ABCD2ATP-binding cassette, sub-family D (ALD), member 2Amnion+3.100.040
128CLCA4chloride channel accessory 4Amnion-3.100.023
129TTBK2tau tubulin kinase 2Amnion+3.090.045
130LOC728543uncharacterized LOC728543Amnion+3.090.011
131SYNGR3synaptogyrin 3Amnion-3.090.028
132ZNRF1zinc and ring finger 1, E3 ubiquitin protein ligaseAmnion+3.090.001
133TSPAN16tetraspanin 16Amnion+3.080.038
134LOC100128002uncharacterized LOC100128002Amnion+3.080.001
135ZIC3Zic family member 3Amnion+3.070.014
136SOX8SRY (sex determining region Y)-box 8Amnion+3.070.004
137CTNND2catenin (cadherin-associated protein), delta 2Amnion+3.060.006
138JSRP1junctional sarcoplasmic reticulum protein 1Amnion+3.060.001
139NCRNA00185non-protein coding RNA 185Amnion-3.060.007
140HSD17B6hydroxysteroid (17-beta) dehydrogenase 6Amnion+3.050.000
141TNFSF12tumor necrosis factor (ligand) superfamily, member 12Amnion+3.050.018
142PTGER3prostaglandin E receptor 3 (subtype EP3)Amnion+3.040.016
143RALGAPA1Ral GTPase activating protein, alpha subunit 1 (catalytic)Amnion+3.040.010
144TNNI2troponin I type 2 (skeletal, fast)Amnion+3.040.005
145RNF168ring finger protein 168, E3 ubiquitin protein ligaseAmnion+3.040.036
146CASRcalcium-sensing receptorAmnion+3.040.008
147LINC00304long intergenic non-protein coding RNA 304Amnion+3.040.001
148NCLNnicalinAmnion+3.030.013
149ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)Amnion+3.030.005
150SGMS2sphingomyelin synthase 2Amnion-3.020.006
151KRTDAPkeratinocyte differentiation-associated proteinAmnion-3.010.039
152CCL13chemokine (C-C motif) ligand 13Amnion+3.010.000
153MRPL39mitochondrial ribosomal protein L39Amnion+3.010.035
154CAMK2Dcalcium/calmodulin-dependent protein kinase II deltaAmnion+3.000.019
155LOC283484uncharacterized LOC283484Amnion+3.000.006
156LCTlactaseAmnion+2.990.014
157KCNA2potassium voltage-gated channel, shaker-related subfamily, member 2Amnion+2.990.040
158PURGpurine-rich element binding protein GAmnion+2.990.015
159NRP2neuropilin 2Amnion+2.990.038
160GAL3ST1galactose-3-O-sulfotransferase 1Amnion+2.980.010
161REXO1REX1, RNA exonuclease 1 homolog (S. cerevisiae)Amnion+2.980.024
162FAM19A5family with sequence similarity 19 (chemokine (C-C motif)-like), member A5Amnion+2.980.005
163FGFR2fibroblast growth factor receptor 2Amnion+2.970.001
164ABLIM2actin binding LIM protein family, member 2Amnion+2.970.009
165IGFL2IGF-like family member 2Amnion-2.970.002
166C9orf156chromosome 9 open reading frame 156Amnion+2.960.000
167C4orf22chromosome 4 open reading frame 22Amnion-2.960.045
168IVLinvolucrinAmnion-2.960.008
169PSMD5proteasome (prosome, macropain) 26S subunit, non-ATPase, 5Amnion+2.960.013
170PTGIRprostaglandin I2 (prostacyclin) receptor (IP)Amnion+2.950.003
171AP5S1adaptor-related protein complex 5, sigma 1 subunitAmnion+2.950.044
172COL5A1collagen, type V, alpha 1Amnion-2.950.049
173BRINP3bone morphogenetic protein/retinoic acid inducible neural-specific 3Amnion+2.950.038
174MSRB3methionine sulfoxide reductase B3Amnion-2.940.033
175SUFUsuppressor of fused homolog (Drosophila)Amnion-2.940.003
176RASSF4Ras association (RalGDS/AF-6) domain family member 4Amnion+2.940.012
177C11orf70chromosome 11 open reading frame 70Amnion-2.930.014
178TMEM217transmembrane protein 217Amnion-2.930.020
179PSMG4proteasome (prosome, macropain) assembly chaperone 4Amnion+2.930.002
180GPR75G protein-coupled receptor 75Amnion+2.930.008
181RNF152ring finger protein 152Amnion+2.920.012
182CLIP3CAP-GLY domain containing linker protein 3Amnion+2.920.010
183POU4F1POU class 4 homeobox 1Amnion+2.920.015
184LOC100287221uncharacterized LOC100287221Amnion+2.920.001
185MYH11myosin, heavy chain 11, smooth muscleAmnion+2.920.011
186ATP6V1C2ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2Amnion-2.910.043
187SLC25A30solute carrier family 25, member 30Amnion+2.910.007
188NPBWR2neuropeptides B/W receptor 2Amnion+2.910.001
189MGC34800uncharacterized protein MGC34800Amnion+2.910.003
190IGHV5-78immunoglobulin heavy variable 5-78 (pseudogene)Amnion+2.900.008
191LOC441178uncharacterized LOC441178Amnion-2.900.020
192FAM149Afamily with sequence similarity 149, member AAmnion-2.900.000
193DSG1desmoglein 1Amnion-2.890.003
194ARF1ADP-ribosylation factor 1Amnion+2.890.016
195SLC18A1solute carrier family 18 (vesicular monoamine transporter), member 1Amnion+2.890.003
196LAMA4laminin, alpha 4Amnion+2.880.001
197SGCDsarcoglycan, delta (35kDa dystrophin-associated glycoprotein)Amnion+2.880.018
198KAZALD1Kazal-type serine peptidase inhibitor domain 1Amnion+2.880.011
199SALL3spalt-like transcription factor 3Amnion+2.870.001
200RCHY1ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligaseAmnion+2.870.014
201CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)Amnion+2.860.023
202PEX13peroxisomal biogenesis factor 13Amnion-2.850.017
203MTMR11myotubularin related protein 11Amnion-2.850.001
204ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 11Amnion-2.850.001
205LTBP1latent transforming growth factor beta binding protein 1Amnion-2.850.022
206KDM5Blysine (K)-specific demethylase 5BAmnion+2.850.006
207NUP133nucleoporin 133kDaAmnion+2.850.024
208ATP1B4ATPase, Na+/K+ transporting, beta 4 polypeptideAmnion+2.840.004
209CWF19L2CWF19-like 2, cell cycle control (S. pombe)Amnion+2.840.049
210SMOC1SPARC related modular calcium binding 1Amnion+2.840.010
211GSN-AS1GSN antisense RNA 1Amnion+2.830.005
212METmet proto-oncogeneAmnion-2.830.002
213FEZF2FEZ family zinc finger 2Amnion+2.830.043
214USP32ubiquitin specific peptidase 32Amnion+2.830.047
215SERPINB7serpin peptidase inhibitor, clade B (ovalbumin), member 7Amnion-2.830.047
216PDK1pyruvate dehydrogenase kinase, isozyme 1Amnion+2.830.033
217MB21D1Mab-21 domain containing 1Amnion+2.820.021
218ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif, 9Amnion-2.820.001
219MGC42157uncharacterized locus MGC42157Amnion+2.820.024
220EPHB4EPH receptor B4Amnion-2.810.000
221USP2ubiquitin specific peptidase 2Amnion-2.810.001
222SLC44A4solute carrier family 44, member 4Amnion+2.810.032
223FETUBfetuin BAmnion+2.800.001
224HAS3hyaluronan synthase 3Amnion+2.790.022
225OR2K2olfactory receptor, family 2, subfamily K, member 2Amnion+2.790.010
226INIPINTS3 and NABP interacting proteinAmnion+2.790.038
227RAMP2receptor (G protein-coupled) activity modifying protein 2Amnion+2.790.007
228ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif, 1Amnion-2.790.021
229NHLH2nescient helix loop helix 2Amnion+2.790.032
230ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2Amnion-2.790.050
231CXorf27chromosome X open reading frame 27Amnion-2.790.003
232RASEFRAS and EF-hand domain containingAmnion-2.790.008
233RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Amnion-2.780.011
234ADAM8ADAM metallopeptidase domain 8Amnion+2.780.028
235STXBP6syntaxin binding protein 6 (amisyn)Amnion-2.780.022
236FLJ25917uncharacterized LOC401585Amnion-2.780.009
237PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)Amnion-2.780.022
238CSPG5chondroitin sulfate proteoglycan 5 (neuroglycan C)Amnion+2.780.013
239DNAJC21DnaJ (Hsp40) homolog, subfamily C, member 21Amnion-2.780.024
240CEP164centrosomal protein 164kDaAmnion+2.770.040
241TSC2tuberous sclerosis 2Amnion+2.770.026
242RGS5regulator of G-protein signaling 5Amnion+2.770.001
243DSTdystoninAmnion-2.760.006
244LOC57399uncharacterized gastric protein ZA52PAmnion+2.760.038
245DCAF4L1DDB1 and CUL4 associated factor 4-like 1Amnion+2.760.042
246C16orf3chromosome 16 open reading frame 3Amnion+2.760.027
247PAX3paired box 3Amnion+2.760.035
248ST3GAL3ST3 beta-galactoside alpha-2,3-sialyltransferase 3Amnion+2.750.025
249PANX2pannexin 2Amnion+2.750.034
250PRIM2primase, DNA, polypeptide 2 (58kDa)Amnion+2.750.043
251FZD10frizzled class receptor 10Amnion-2.740.005
252WNT3wingless-type MMTV integration site family, member 3Amnion-2.740.015
253BCANbrevicanAmnion+2.740.005
254TINCRtissue differentiation-inducing non-protein coding RNAAmnion-2.740.014
255CELSR1cadherin, EGF LAG seven-pass G-type receptor 1Amnion+2.730.036
256CALD1caldesmon 1Amnion+2.730.010
257CTU2cytosolic thiouridylase subunit 2 homolog (S. pombe)Amnion+2.730.047
258VGLL3vestigial-like family member 3Amnion-2.730.025
259ADGBandroglobinAmnion-2.730.035
260TPPPtubulin polymerization promoting proteinAmnion+2.730.041
261CBX2chromobox homolog 2Amnion+2.720.007
262CSMD1CUB and Sushi multiple domains 1Amnion+2.720.021
263CELF4CUGBP, Elav-like family member 4Amnion+2.720.033
264PLA2R1phospholipase A2 receptor 1, 180kDaAmnion-2.720.010
265RNASEH2Cribonuclease H2, subunit CAmnion+2.710.038
266TPM2tropomyosin 2 (beta)Amnion+2.710.021
267CYP1A1cytochrome P450, family 1, subfamily A, polypeptide 1Amnion-2.710.017
268WWC1WW and C2 domain containing 1Amnion-2.710.000
269GAP43growth associated protein 43Amnion+2.710.026
270GLT8D1glycosyltransferase 8 domain containing 1Amnion+2.710.023
271CEMIPcell migration inducing protein, hyaluronan bindingAmnion+2.710.002
272ARIH2OSariadne homolog 2 opposite strandAmnion-2.700.045
273FGFR1fibroblast growth factor receptor 1Amnion+2.700.003
274MS4A1membrane-spanning 4-domains, subfamily A, member 1Amnion-2.700.015
275SNRPB2small nuclear ribonucleoprotein polypeptide BAmnion+2.690.027
276MORN1MORN repeat containing 1Amnion+2.690.001
277ODF3Bouter dense fiber of sperm tails 3BAmnion+2.690.042
278SCINscinderinAmnion-2.690.032
279ABCA12ATP-binding cassette, sub-family A (ABC1), member 12Amnion-2.690.013
280PPP4R1Lprotein phosphatase 4, regulatory subunit 1-likeAmnion+2.690.019
281SLITRK6SLIT and NTRK-like family, member 6Amnion-2.690.020
282CSMD2CUB and Sushi multiple domains 2Amnion+2.680.009
283FOLR2folate receptor 2 (fetal)Amnion+2.680.025
284MIB2mindbomb E3 ubiquitin protein ligase 2Amnion+2.680.040
285HBS1LHBS1-like (S. cerevisiae)Amnion-2.680.007
286RENreninAmnion-2.680.036
287PDE1Aphosphodiesterase 1A, calmodulin-dependentAmnion-2.670.035
288MROH1maestro heat-like repeat family member 1Amnion+2.670.015
289KRT23keratin 23 (histone deacetylase inducible)Amnion-2.670.015
290AHI1Abelson helper integration site 1Amnion+2.670.010
291EPHB1EPH receptor B1Amnion-2.660.014
292KCNK12potassium channel, subfamily K, member 12Amnion-2.660.039
293RGS17regulator of G-protein signaling 17Amnion-2.660.009
294PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)Amnion-2.660.008
295CCDC110coiled-coil domain containing 110Amnion-2.660.015
296CCBE1collagen and calcium binding EGF domains 1Amnion+2.660.019
297INSL4insulin-like 4 (placenta)Amnion-2.660.006
298BBOX1butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1Amnion+2.660.044
299IL1Ainterleukin 1, alphaAmnion-2.650.000
300MAPKAPK2mitogen-activated protein kinase-activated protein kinase 2Amnion-2.650.035
301AMHanti-Mullerian hormoneAmnion+2.650.039
302LOC284933uncharacterized LOC284933Amnion+2.650.040
303TDRPtestis development related proteinAmnion-2.650.018
304SMOC2SPARC related modular calcium binding 2Amnion-2.640.024
305BNC1basonuclin 1Amnion-2.630.019
306EIF4EBP2eukaryotic translation initiation factor 4E binding protein 2Amnion-2.630.045
307TTC39Ctetratricopeptide repeat domain 39CAmnion-2.630.001
308SMTNsmoothelinAmnion-2.620.006
309FOSL2FOS-like antigen 2Amnion-2.620.035
310CAV1caveolin 1, caveolae protein, 22kDaAmnion-2.600.010
311NCKAP1NCK-associated protein 1Amnion-2.600.043
312TXLNGtaxilin gammaAmnion-2.600.001
313RXFP1relaxin/insulin-like family peptide receptor 1Amnion-2.590.033
314KRTAP3-1keratin associated protein 3-1Amnion-2.580.026
315LOC100130232LP2209Amnion-2.580.038
316ZNF426zinc finger protein 426Amnion-2.570.021
317DENND4CDENN/MADD domain containing 4CAmnion-2.570.042
318ANKS6ankyrin repeat and sterile alpha motif domain containing 6Amnion-2.570.008
319ACOT12acyl-CoA thioesterase 12Amnion-2.570.037
320KLF5Kruppel-like factor 5 (intestinal)Amnion-2.560.025
321NIT1nitrilase 1Amnion-2.560.031
322CNSTconsortin, connexin sorting proteinAmnion-2.560.047
323PACSIN3protein kinase C and casein kinase substrate in neurons 3Amnion-2.560.002
324STYK1serine/threonine/tyrosine kinase 1Amnion-2.560.016
325SLC6A14solute carrier family 6 (amino acid transporter), member 14Amnion-2.550.028
326ITGB6integrin, beta 6Amnion-2.550.012
327MMP3matrix metallopeptidase 3 (stromelysin 1, progelatinase)Amnion-2.540.021
328FAM84Afamily with sequence similarity 84, member AAmnion-2.540.025
329SOSTDC1sclerostin domain containing 1Amnion-2.540.045
330NT5DC45'-nucleotidase domain containing 4Amnion-2.530.023
331VGLL1vestigial-like family member 1Amnion-2.520.039
332ZMYM6zinc finger, MYM-type 6Amnion-2.520.014
333MTIF3mitochondrial translational initiation factor 3Amnion-2.510.002
334NUP210Lnucleoporin 210kDa-likeAmnion-2.510.042
335GABRPgamma-aminobutyric acid (GABA) A receptor, piAmnion-2.510.003
336RHBDL2rhomboid, veinlet-like 2 (Drosophila)Amnion-2.500.050
337RALGPS2Ral GEF with PH domain and SH3 binding motif 2Amnion-2.500.029
338USP9Yubiquitin specific peptidase 9, Y-linkedAmnion-2.500.015
339LINC00240long intergenic non-protein coding RNA 240Amnion-2.500.046
340OTUD4OTU deubiquitinase 4Amnion-2.490.043
341TMEM45Btransmembrane protein 45BAmnion-2.480.044
342AURKCaurora kinase CAmnion-2.480.045
343SIM1single-minded family bHLH transcription factor 1Amnion-2.480.006
344ESRP1epithelial splicing regulatory protein 1Amnion-2.470.033
345AGRPagouti related protein homolog (mouse)Amnion-2.460.003
346FRAS1Fraser syndrome 1Amnion-2.460.008
347SYNPO2synaptopodin 2Amnion-2.460.020
348TFAP2Atranscription factor AP-2 alpha (activating enhancer binding protein 2 alpha)Amnion-2.450.012
349MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4Amnion-2.440.006
350RNASE7ribonuclease, RNase A family, 7Amnion-2.440.028
351CANT1calcium activated nucleotidase 1Amnion-2.430.004
352A2ML1alpha-2-macroglobulin-like 1Amnion-2.430.030
353HIST1H3Ghistone cluster 1, H3gAmnion-2.430.037
354PTPRRprotein tyrosine phosphatase, receptor type, RAmnion-2.420.049
355PKP2plakophilin 2Amnion-2.420.011
356LPHN2latrophilin 2Amnion-2.410.033
357KDM8lysine (K)-specific demethylase 8Amnion-2.410.021
358ZFPM2zinc finger protein, FOG family member 2Amnion-2.390.007
359FBN1fibrillin 1Amnion-2.390.009
360LOC100127940uncharacterized LOC100127940Amnion-2.380.030
361SP4Sp4 transcription factorAmnion-2.380.049
362DOK4docking protein 4Amnion-2.380.027
363LAMC2laminin, gamma 2Amnion-2.370.020
364CAPScalcyphosineAmnion-2.370.017
365AVPR1Barginine vasopressin receptor 1BAmnion-2.350.001
366AJUBAajuba LIM proteinAmnion-2.350.029
367DSC3desmocollin 3Amnion-2.340.040
368CAPN14calpain 14Amnion-2.340.012
369PARD3Bpar-3 family cell polarity regulator betaAmnion-2.340.046
370OLFM1olfactomedin 1Amnion-2.330.024
371TOP3Btopoisomerase (DNA) III betaAmnion-2.330.034
372SNAPC5small nuclear RNA activating complex, polypeptide 5, 19kDaAmnion-2.330.017
373SNCBsynuclein, betaAmnion-2.320.006
374CUL3cullin 3Amnion-2.310.049
375GULP1GULP, engulfment adaptor PTB domain containing 1Amnion-2.310.047
376SFXN3sideroflexin 3Amnion-2.310.024
377YAP1Yes-associated protein 1Amnion-2.310.037
378SYN1synapsin IAmnion-2.300.050
379HEATR5BHEAT repeat containing 5BAmnion-2.300.036
380CCL22chemokine (C-C motif) ligand 22Amnion-2.300.033
381C20orf195chromosome 20 open reading frame 195Amnion-2.290.027
382TMEM45Atransmembrane protein 45AAmnion-2.280.009
383TNRC6Atrinucleotide repeat containing 6AAmnion-2.280.029
384KRT4keratin 4Amnion-2.280.030
385BCORL1BCL6 corepressor-like 1Amnion-2.280.006
386P2RY2purinergic receptor P2Y, G-protein coupled, 2Amnion-2.270.046
387SH3GL3SH3-domain GRB2-like 3Amnion-2.270.042
388SLIT2slit homolog 2 (Drosophila)Amnion-2.260.008
389AREGamphiregulinAmnion-2.250.046
390DUX1double homeobox 1Amnion-2.250.008
391CXADRcoxsackie virus and adenovirus receptorAmnion-2.250.045
392FOXE1forkhead box E1 (thyroid transcription factor 2)Amnion-2.230.040
393TNRC6Ctrinucleotide repeat containing 6CAmnion-2.230.003
394ZNF750zinc finger protein 750Amnion-2.230.044
395ZBED2zinc finger, BED-type containing 2Amnion-2.230.018
396FSTL1follistatin-like 1Amnion-2.230.045
397RBPMSRNA binding protein with multiple splicingAmnion-2.220.034
398CDS1CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1Amnion-2.220.036
399CPEB4cytoplasmic polyadenylation element binding protein 4Amnion-2.220.003
400FLJ37035uncharacterized LOC399821Amnion-2.200.033

Expression patterns in normal tissues for genes affiliated with Neural Tube Defects

Search GEO for disease gene expression data for Neural Tube Defects.

Pathways for genes affiliated with Neural Tube Defects

About this section

Pathways related to Neural Tube Defects according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Vitamin B12 Metabolism37
10.2MTRR, MTHFR
210.1CBS, MTHFR
3
Show member pathways
Glycine Metabolism37
glycine biosynthesis I37
folate transformations37
10.0MTR, MTHFD1
4
Show member pathways
cysteine biosynthesis/homocysteine degradation37
10.0MTR, CBS
510.0SLC19A1, TCN2
6
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
9.9MTR, MTHFR, CBS
7
Show member pathways
thioredoxin pathway37
9.9CBS, MTHFR, MTR
89.8AFP, SCRIB, SNAI2
9
Show member pathways
creatine-phosphate biosynthesis37
glycine degradation (creatine biosynthesis)37
putrescine biosynthesis III37
spermidine biosynthesis I37
tryptophan degradation via kynurenine37
spermine biosynthesis37
urea cycle37
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I37
tyrosine degradation I37
L-carnitine biosynthesis37
methylthiopropionate biosynthesis37
2-oxoglutarate decarboxylation to succinyl-CoA37
S-methyl-5-thioadenosine degradation II37
9.8MTR, MTRR, CBS
10
Show member pathways
9.8MTR, MTRR, CBS
119.7T, AFP, SCRIB, SNAI2
129.2TCN2, MTHFD1, MTHFR, MTRR, MTR, SLC19A1
13
Show member pathways
flavin biosynthesis IV (mammalian)37
molybdenum cofactor biosynthesis37
coenzyme A biosynthesis37
thiamin salvage III37
alanine biosynthesis III37
thio-molybdenum cofactor biosynthesis37
biotin-carboxyl carrier protein assembly37
9.2TCN2, MTHFD1, MTHFR, MTRR, MTR, SLC19A1
14
Show member pathways
One Carbon Metabolism37
dTMP de novo biosynthesis (mitochondrial)37
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate37
Trans-sulfuration and one carbon metabolism37
methionine salvage37
Methionine metabolism59
9.2MTR, MTRR, MTHFR, MTHFD1, TCN2, CBS
15
Show member pathways
9.0CBS, TCN2, MTHFD1, MTHFR, MTRR, MTR

Compounds for genes affiliated with Neural Tube Defects

About this section

Compounds related to Neural Tube Defects according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1vitamin b-complex, plain5010.5MTHFR, MTRR
25-Methyltetrahydrofolic acid2510.5MTR, MTHFR
3methyl-group4410.5MTHFR, MTR
4cob(ii)alamin44 2511.4MTR, MTRR
5ch2h4folate4410.4MTHFR, MTHFD1
6Cob(I)alamin2510.4MTRR, MTR
7corrinoid4410.4MTR, TCN2
85,10-Methylene-THF2510.4MTHFD1, MTHFR
9Pyridoxine25 1211.3MTHFR, CBS
10benazepril44 50 1212.3MTR, MTHFR
11mercaptopurine50 1211.3SLC19A1, MTHFR
12adenosylcobalamin44 2511.3MTR, MTHFR, TCN2
13folic acid50 25 1212.3SLC19A1, MTRR, MTHFR
14Tetrahydrofolic acid25 1211.3MTR, MTHFR, MTHFD1
15dihydrofolate4410.2SLC19A1, MTR, MTHFR
16L-Methionine25 1211.2MTRR, MTR
17pyridoxal 5-phosphate4410.2MTR, CBS, MTHFR
18cyanocobalamin50 25 1212.1TCN2, MTHFR, MTRR, MTR
19tetrahydrofolate4410.1MTHFR, MTRR, SLC19A1, MTR
20hydroxocobalamin44 1211.1TCN2, MTHFR, MTRR, MTR
21b vitamins4410.1CBS, MTHFR, MTRR, MTR
22betaine44 2511.1CBS, MTR, MTRR, MTHFR
23irinotecan44 50 1212.1AFP, MTHFR, SLC19A1
2410-formyltetrahydrofolate4410.1MTR, SLC19A1, MTHFR, MTHFD1
25s-adenosylhomocysteine44 2511.1CBS, MTHFR, MTR, MTRR
26carboplatin44 50 1212.1SLC19A1, MTHFR, AFP
275,10-methenyltetrahydrofolate4410.1CBS, MTR, MTHFR, MTHFD1
28vincristine44 50 1211.9AFP, SLC19A1, MTR
295-methyltetrahydrofolate44 1210.9MTRR, MTHFR, SLC19A1, CBS, MTR
30methylcobalamin44 2510.9MTR, CBS, TCN2, MTHFR, MTRR
31methylmalonic acid44 2510.9TCN2, MTRR, MTR, CBS, MTHFR
32carbon449.9MTHFR, MTR, AFP
33s-adenosylmethionine44 25 1211.8MTR, MTRR, CBS, MTHFR, SLC19A1
34vitamin b6449.8TCN2, CBS, MTR, MTHFR, MTHFD1
35purine44 2510.8SLC19A1, MTR, MTHFR, MTHFD1, CBS
36nadph44 2510.7MTR, MTHFR, MTHFD1, MTRR
37cystathionine449.6CBS, MTR, MTRR, MTHFR, TCN2, MTHFD1
38cobalamin44 2510.6MTHFD1, TCN2, CBS, MTHFR, MTRR, MTR
39copper44 2510.6AFP, CBS, MTR
40thymidylate449.6MTRR, CBS, MTHFD1, MTHFR, SLC19A1, MTR
41vitamin b12449.6AFP, TCN2, MTR, MTHFR, CBS, MTRR
42alanine449.5SLC19A1, MTRR, MTHFR, ZIC2, AFP
43glutamate449.5MTRR, MTHFR, CBS, AFP, MTR, SLC19A1
44homocysteine44 2510.4MTR, CBS, TCN2, MTHFD1, MTRR, MTHFR
45methionine449.4SLC19A1, MTHFR, TCN2, MTRR, MTR, CBS
46methotrexate50 44 1211.3MTHFD1, MTR, AFP, CBS, SLC19A1, MTHFR
47cisplatin44 50 60 1212.3MTR, AFP, MTHFR, SLC19A1
48zinc44 2510.3ZIC2, AFP, CBS, MTR, SNAI2, ZIC1
49serine449.2MTHFR, SLC19A1, AFP, CBS, MTHFD1, MTRR
50folate449.1MTHFD1, TCN2, MTHFR, AFP, SLC19A1, MTRR

GO Terms for genes affiliated with Neural Tube Defects

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Cellular components related to Neural Tube Defects according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057378.8ZIC3, ZIC2, ZIC1, SNAI2, MTRR, AFP

Biological processes related to Neural Tube Defects according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1lateral sprouting involved in lung morphogenesisGO:06049010.5VANGL2, CELSR1
2planar dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:06048910.5VANGL2, CELSR1
3orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:06048810.5VANGL2, CELSR1
4establishment of body hair planar orientationGO:04810510.5VANGL2, CELSR1
5apical protein localizationGO:04517610.4CELSR1, VANGL2
6planar cell polarity pathway involved in neural tube closureGO:09017910.4CELSR1, VANGL2
7establishment of planar polarityGO:00173610.4CELSR1, VANGL2, FUZ
8homocysteine metabolic processGO:05066710.4MTHFR, CBS
9tetrahydrofolate interconversionGO:03599910.4MTHFR, MTHFD1
10hair follicle developmentGO:00194210.3FUZ, VANGL2, CELSR1
11response to folic acidGO:05159310.3CBS, MTHFR
12post-anal tail morphogenesisGO:03634210.3VANGL2, T
13methylationGO:03225910.3MTR, MTRR
14regulation of smoothened signaling pathwayGO:00858910.3FUZ, ZIC1
15wound healingGO:04206010.3SCRIB, VANGL2, CELSR1
16methionine biosynthetic processGO:00908610.3MTHFD1, MTHFR, MTRR
17SMAD protein signal transductionGO:06039510.2T, AFP
18cobalamin metabolic processGO:00923510.2MTR, MTRR, TCN2
19sulfur amino acid metabolic processGO:00009610.2CBS, MTRR, MTR
20regulation of actin cytoskeleton organizationGO:03295610.2CELSR1, VANGL2
21anterior/posterior pattern specificationGO:00995210.1VANGL2, CELSR1, ZIC3, ALX1
22folic acid metabolic processGO:04665510.0SLC19A1, MTRR, MTHFR, MTHFD1
23positive regulation of fat cell differentiationGO:04560010.0SNAI2, DACT1
24brain developmentGO:00742010.0ALX1, ZIC2, ZIC1
25cellular nitrogen compound metabolic processGO:0346419.8CBS, MTRR, MTR
26positive regulation of transcription, DNA-templatedGO:0458939.8ZIC1, ZIC2, ZIC3, ALX1
27neural tube closureGO:0018439.8ALX1, FUZ, T, SCRIB, VANGL2, CELSR1
28water-soluble vitamin metabolic processGO:0067679.6TCN2, MTHFD1, MTHFR, MTRR, MTR, SLC19A1
29vitamin metabolic processGO:0067669.6TCN2, MTHFD1, MTHFR, MTRR, MTR, SLC19A1
30negative regulation of transcription from RNA polymerase II promoterGO:0001229.5ALX1, SNAI2, T, DACT1
31small molecule metabolic processGO:0442819.3CBS, TCN2, MTHFD1, MTHFR, MTRR, MTR

Molecular functions related to Neural Tube Defects according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1modified amino acid bindingGO:07234110.1MTHFR, CBS
2cobalamin bindingGO:0314199.9MTR, TCN2
3sequence-specific DNA binding transcription factor activityGO:0037009.5ALX1, ZIC3, ZIC2, ZIC1, T
4metal ion bindingGO:0468728.6AFP, CBS, TCN2, SNAI2, ZIC1, ZIC2

Products for genes affiliated with Neural Tube Defects

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Sources for Neural Tube Defects

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet