NTDS
MCID: NRL016
MIFTS: 69

Neural Tube Defects (NTDS) malady

Neuronal, Fetal categories

Summaries for Neural Tube Defects

Sources:
43NIH Rare Diseases, 34MedlinePlus, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Neural tube defects are birth defects of the brain, spine, or spinal cord. they happen in the first month of pregnancy, often before a woman even knows that she is pregnant. the two most common neural tube defects are spina bifida and anencephaly. in spina bifida, the fetal spinal column doesn't close completely. there is usually nerve damage that causes at least some paralysis of the legs. in anencephaly, most of the brain and skull do not develop. babies with anencephaly are either stillborn or die shortly after birth. another type of defect, chiari malformation, causes the brain tissue to extend into the spinal canal. the exact causes of neural tube defects aren't known. you're at greater risk of having an infant with a neural tube defect if you are obese have poorly controlled diabetes take certain antiseizure medicines getting enough folic acid, a type of b vitamin, before and during pregnancy prevents most neural tube defects. neural tube defects are usually diagnosed before the infant is born, through lab or imaging tests. there is no cure for neural tube defects. the nerve damage and loss of function that are present at birth are usually permanent. however, a variety of treatments can sometimes prevent further damage and help with complications. nih: national institute of child health and human development

MalaCards: Neural Tube Defects, also known as isolated spina bifida, is related to spina bifida and anencephaly, and has symptoms including meningocele, spina bifida and myelomeningocele. An important gene associated with Neural Tube Defects is MTHFR (methylenetetrahydrofolate reductase (NAD(P)H)), and among its related pathways are Cobalamin (Cbl, vitamin B12) transport and metabolism and Wnt / Hedgehog / Notch. The compounds b vitamins and 5-methyltetrahydrofolate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are limbs/digits/tail and embryogenesis.

NIH Rare Diseases:43 Neural tube defects (ntds) refers to a group of abnormalities resulting from abnormal development of the brain, spine and/or spinal column. during the development of an affected embryo, a structure called the neural tube does not close completely as it should, resulting in a hole somewhere along the spinal column. specific examples of types of ntds include spina bifida, anencephaly, and encephalocele. symptoms vary depending on the type of ntd present but often include various forms of physical and/or mental disabilities. many affected individuals do not survive. the exact cause of ntds is not known but is thought to involve both genetic and nongenetic factors. getting enough folic acid before and during pregnancy can reduce the risk of some ntds. treatment depends on the severity and type of defect and may include surgery. last updated: 11/6/2013

CDC:3 Neglected Tropical Diseases (NTDs) are a group of parasitic and bacterial diseases that cause substantial illness for more than one billion people globally. Affecting the world's poorest people, NTDs impair physical and cognitive development, contribute to mother and child illness and death, make it difficult to farm or earn a living, and limit productivity in the workplace. As a result, NTDs trap the poor in a cycle of poverty and disease.

Wikipedia:64 Neural tube defects (NTDs) are one of the most common birth defects, affecting approximately 1,500... more...

Description from OMIM:47 182940,301410,601634

Aliases & Classifications for Neural Tube Defects

Sources:
43NIH Rare Diseases, 20GeneTests, 22GTR, 47OMIM, 45Novoseek, 34MedlinePlus, 49Orphanet, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
isolated spina bifida:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-5/10000; Age of onset: Neonatal/infancy


Aliases & Descriptions:

neural tube defects 43 20 22 47 45 34
isolated spina bifida 49
dysraphism 43
ntds 43


External Ids:

MESH via Orphanet36 D016135
ICD10 via Orphanet26 Q05
SNOMED-CT via Orphanet58 67531005
UMLS via Orphanet62 C0080178

Related Diseases for Neural Tube Defects

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Neural Tube Defects via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1spina bifida31.1MTRR, MTHFD1, MTHFR, MTR, AFP, CBS
2anencephaly31.1MTHFR, AFP
3omphalocele30.8AFP
4down syndrome30.7MTR, MTHFR, MTRR, AFP, CBS, SLC19A1
5myelomeningocele30.6MTHFR, CBS
6craniorachischisis30.4VANGL2
7neural tube defects, folate-sensitive30.4MTRR, MTR
8cleft palate30.2MTR, SNAI2, MTHFR, SLC19A1
9hyperhomocysteinemia30.2SLC19A1, CBS, MTR, MTHFR, MTRR
10homocystinuria30.2MTRR, MTHFR, CBS, MTR
11thrombophilia30.2CBS, MTHFR
12vascular disease30.2CBS
13gastroschisis30.2AFP
14occult spinal dysraphism10.9
15n syndrome10.9
16encephalocele10.6
17exencephaly10.5
18iniencephaly10.5
19encephaloceles10.4
20meningocele10.4
21meckel syndrome10.4
22abdominal wall defect10.4
23diabetic embryopathy10.4
24cataract-congenital heart disease-neural tube defect syndrome10.4
25waardenburg's syndrome10.3
26spina bifida occulta10.3
27lipomyelomeningocele10.3
28mthfr gene mutation10.3
29vangl1-related neural tube defect10.3
30vangl2-related neural tube defect10.3
31mthfr thermolabile variant10.3
32tethered spinal cord syndrome10.3
33spinal cord lipoma10.2
34spina bifida aperta10.2
35neurogenic bladder10.2
36trachoma10.1
37cartilage-hair hypoplasia10.1
38syndactyly10.1
39spondylocostal dysostosis10.1
40polydactyly10.1
41adjustment disorder10.1
42glucose intolerance10.1
43congenital diaphragmatic hernia10.1
44holoprosencephaly10.1
45urinary tract obstruction10.1
46waardenburg syndrome type i10.1
47anophthalmia plus syndrome10.1
48arachnoid cysts10.1
49circumscribed cutaneous aplasia of the vertex10.1
50diastematomyelia10.1

Graphical network of the top 20 diseases related to Neural Tube Defects:



Diseases related to neural tube defects

Clinical Features for Neural Tube Defects

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

182940,301410,601634

Clinical synopsis from OMIM:

182940

Symptoms:

49 (show all 25)
  • meningocele
  • spina bifida
  • myelomeningocele
  • impotence/painful erection/priapism/erection troubles
  • hydrocephaly
  • arnold-chiari anomaly
  • sphincter dysfunction
  • motor deficit/trouble
  • hypotonia
  • sensitive trouble/deficit
  • intellectual deficit/mental/psychomotor retardation/learning disability
  • short stature/dwarfism/nanism
  • facial cleft
  • anomalies of the ribs
  • scoliosis
  • vertebral segmentation anomaly/hemivertebrae
  • talipes-varus/metatarsal varus
  • congenital cardiac anomaly/malformation/cardiopathy
  • anencephaly/acrania
  • encephalocele/exencephaly
  • syringomelia
  • hypertonia/spasticity/rigidity/stiffness
  • seizures/epilepsy/absences/spasms/status epilepticus
  • hip dislocation/dysplasia/coxa valga/coxa vara/coxa plana
  • early death/lethality

Drugs & Therapeutics for Neural Tube Defects

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Neural Tube Defects

Drug clinical trials:

Search ClinicalTrials for Neural Tube Defects

Search NIH Clinical Center for Neural Tube Defects

Search CenterWatch for Neural Tube Defects

Genetic Tests for Neural Tube Defects

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Neural Tube Defects:

id Genetic test Affiliating Genes
1 Neural Tube Defect20 22

Anatomical Context for Neural Tube Defects

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Neural Tube Defects:

33
Bone marrow, Whole blood, Brain, Spinal cord, Heart, Skeletal muscle, Skin, Placenta, T cells, B cells, Fetal brain

Animal Models for Neural Tube Defects or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Neural Tube Defects:

37 (show all 17)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.7T, MTHFR, SCRIB, ZIC2, ZIC3, CBS
2MP:000538010.7T, SNAI2, SCRIB, ZIC2, ZIC3, CBS
3MP:000539010.7ZIC1, ZIC3, ZIC2, SNAI2, MTHFR, T
4MP:000363110.7SNAI2, SCRIB, ZIC2, ZIC3, ZIC1, MTHFR
5MP:000537810.7MTHFD1, MTRR, SNAI2, SCRIB, ZIC3, ZIC1
6MP:000538910.7ZIC3, SCRIB, MTHFR, AFP, T, CBS
7MP:001076810.7ALX1, MTR, MTHFR, MTHFD1, SNAI2, SCRIB
8MP:000538210.7ZIC3, ZIC2, SNAI2, T, CBS, VANGL2
9MP:000538110.6ZIC3, SCRIB, SNAI2, T, VANGL2, DACT1
10MP:000537610.6AFP, MTR, MTHFR, MTHFD1, MTRR, SHMT1
11MP:000539110.6ZIC3, SCRIB, SNAI2, CBS, VANGL2, FUZ
12MP:000537710.6ZIC3, SCRIB, VANGL2, VANGL1, FUZ, CELSR1
13MP:000538810.5ZIC3, SCRIB, VANGL2, VANGL1, FUZ, CELSR1
14MP:000536710.5DACT1, VANGL2, CBS, T, SCRIB
15MP:000538610.4ZIC1, ZIC3, ZIC2, SNAI2, AFP, T
16MP:000538510.3ZIC3, ZIC2, T, CBS, VANGL2, VANGL1
17MP:001077110.1ZIC2, SNAI2, T, CBS, SLC19A1, CELSR1

Publications for Neural Tube Defects

Sources:
51PubMed
See all sources

Articles related to Neural Tube Defects:

(show top 50)    (show all 657)
idTitleAuthorsYear
1
Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid. (23104247)
2013
2
Folic acid for the prevention of neural tube defects. (24080839)
2013
3
Mutations in the COPII vesicle component gene SEC24B are associated with human neural tube defects. (23592378)
2013
4
Birth prevalence of neural tube defects: a population-based study in South-Eastern Hungary. (23108919)
2013
5
Fetal surgery for neural tube defects. (22611118)
2013
6
Neural tube defects, folate, and immune modulation. (24078477)
2013
7
Genetic diversity of stem cells and their functional impact on the development of neural tube defects in Eastern population of India. (23979878)
2013
8
Spinal neural tube defects in Lagos University Teaching Hospital, Nigeria. (23175875)
2012
9
Adding folate to the contraceptive pill: a new concept for the prevention of neural tube defects. (22272814)
2012
10
Reduction in valproic acid-induced neural tube defects by maternal immune stimulation: role of apoptosis. (22767483)
2012
11
Novel VANGL1 Gene Mutations in 144 Slovakian, Romanian and German Patients with Neural Tube Defects. (23326252)
2012
12
Maternal occupational exposure to organic solvents during early pregnancy and risks of neural tube defects and orofacial clefts. (22843436)
2012
13
Neural tube defects on the Texas-Mexico border: what we've learned in the 20 years since the Brownsville cluster. (22945287)
2012
14
Maternal occupational exposure to organic solvents during early pregnancy and risks of neural tube defects and orofacial clefts. (22447643)
2012
15
Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans. (21840926)
2011
16
Policy statement on folic acid and neural tube defects. (21552133)
2011
17
Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population. (21204206)
2011
18
Effect of exposure to trace elements in the soil on the prevalence of neural tube defects in a high-risk area of China. (21565679)
2011
19
Prevalence of cystathionine beta synthase gene mutation 852Ins68 as a possible risk for neural tube defects in eastern India. (22002135)
2011
20
Commentary: folate and neural tube defects--the influence of Smithells et al. on research and policy in the Antipodes. (22039192)
2011
21
Biochemical screening of fetal aneuploidies and neural tube defects by "double-test" in Croatia: a 10 years' experience. (22053587)
2011
22
Long-term effect of low-dose folic acid intake: potential effect of mandatory fortification on the prevention of neural tube defects. (21593499)
2011
23
Nitrosatable drug exposure during early pregnancy and neural tube defects in offspring: National Birth Defects Prevention Study. (22047825)
2011
24
Folic acid and other potential measures in the prevention of neural tube defects. (22123637)
2011
25
Neural tube defects in native fars ethnicity in northern iran. (23113030)
2010
26
Spatial analysis of neural tube defects in a rural coal mining area. (21161805)
2010
27
Is there an outbreak of neural tube defects happening in Iraq? (20635025)
2010
28
Reproductive and sphingolipid metabolic effects of fumonisin B(1) and its alkaline hydrolysis product in LM/Bc mice: hydrolyzed fumonisin B(1) did not cause neural tube defects. (19783636)
2009
29
Lack of association between folate-receptor autoantibodies and neural-tube defects. (19587340)
2009
30
The incidence of neural tube defects in Norway and the Arkhangelskaja Oblast in Russia and the association with maternal age. (19353336)
2009
31
Postnatal management and outcome for neural tube defects including spina bifida and encephalocoeles. (19194999)
2009
32
Genetics of human neural tube defects. (19808787)
2009
33
Folate awareness and the prevalence of neural tube defects in South Australia, 1966-2007. (19012555)
2008
34
Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. (18053387)
2007
35
Folic acid and the decline in neural tube defects in Arkansas. (17487022)
2007
36
Mouse mutants with neural tube closure defects and their role in understanding human neural tube defects. (17177317)
2007
37
Maternal flu or fever, medication use, and neural tube defects: a population-based case-control study in Northern China. (17216625)
2007
38
Reduced folate carrier gene is a risk factor for neural tube defects in a Chinese population. (15799025)
2005
39
Genetic risk factors of neural tube defects]. (12810987)
2002
40
Frequency of the thermolabile variant C677T in the MTHFR gene and lack of association with neural tube defects in the State of Yucatan, Mexico. (12431255)
2002
41
Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23. (11401431)
2001
42
Promoter haplotype combinations of the platelet-derived growth factor alpha-receptor gene predispose to human neural tube defects. (11175793)
2001
43
Investigation of folate pathway gene polymorphisms and the incidence of neural tube defects in a Texas hispanic population. (10833330)
2000
44
High prevalence of the thermolabile methylenetetrahydrofolate reductase variant in Mexico: a country with a very high prevalence of neural tube defects. (10607475)
1999
45
Neural-tube defects are associated with low concentrations of cobalamin (vitamin B12) in amniotic fluid. (9664599)
1998
46
Health promotion in a primary health care setting. Neural tube defects and folate. (17987155)
1997
47
Lack of serologic evidence for an association between Cache Valley Virus infection and anencephaly and other neural tube defects in Texas. (9204303)
1997
48
Splotch locus mouse mutants: models for neural tube defects and Waardenburg syndrome type I in humans. (1552554)
1992
49
Neural tube defects and omphalocele in trisomy 18. (2924433)
1989
50
Amniotic fluid cholinesterase of valproate-induced exencephaly in the mouse: an animal model for prenatal diagnosis of neural tube defects. (3142446)
1988

Genetic Variations for Neural Tube Defects

Sources:
63UniProtKB/Swiss-Prot
See all sources

Genetic disease variations for Neural Tube Defects:

63 (show all 17)
id Symbol AA change Variation SNP ID
1CELSR1p.Ala773ValVAR_067213rs12170597
2CELSR1p.Arg2438GlnVAR_067215rs199688538
3CELSR1p.Ser2964LeuVAR_067217rs6008777
4CELSR1p.Pro2983AlaVAR_067218rs61741871
5DACT1p.Asn356LysVAR_068429
6SCRIBp.Pro454SerVAR_067219
7SCRIBp.Arg1535GlnVAR_067220
8VANGL1p.Arg274GlnVAR_035210
9VANGL1p.Met328ThrVAR_035211
10VANGL1p.Ser83LeuVAR_062322rs146695372
11VANGL1p.Phe153SerVAR_062323
12VANGL1p.Arg181GlnVAR_062325
13VANGL1p.Leu202PheVAR_062326
14VANGL1p.Ala404SerVAR_062329
15VANGL2p.Ser84PheVAR_067221
16VANGL2p.Arg353CysVAR_067222
17VANGL2p.Phe437SerVAR_067223

Expression for genes affiliated with Neural Tube Defects

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Neural Tube Defects

Search GEO for disease gene expression data for Neural Tube Defects.

Pathways for genes affiliated with Neural Tube Defects

Sources:
54Reactome, 4Cell Signaling Technology, 38NCBI BioSystems Database, 30KEGG, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Neural Tube Defects according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5MTRR, MTR
210.5T, AFP, SNAI2, SCRIB
310.5MTR, CBS
4
Hide members
10.5MTR, CBS
510.5CBS, MTR
6
Hide members
10.4MTRR, MTR, CBS
7
Hide members
10.4CBS, MTR, MTRR
8
Hide members
10.4MTHFR, MTR, SHMT1, CBS
9
Hide members
10.4MTHFD1, MTHFR, MTR, SHMT1
10
Hide members
10.4MTRR, MTHFD1, MTHFR, MTR, SHMT1
1110.4CBS, SHMT1, MTR, MTRR
12
Hide members
10.4MTRR, MTHFD1, MTHFR, MTR, SHMT1, SLC19A1
13
Hide members
10.4CBS, SHMT1, MTR, MTHFR, MTHFD1, MTRR
14
Hide members
10.4CBS, SHMT1, MTR, MTHFR, MTHFD1, MTRR

Compounds for genes affiliated with Neural Tube Defects

Sources:
45Novoseek, 11DrugBank, 24HMDB, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Neural Tube Defects according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1b vitamins4510.8CBS, SHMT1, MTR, MTHFR, MTRR
25-methyltetrahydrofolate45 1111.8MTRR, MTHFR, MTR, CBS, SLC19A1
3tetrahydrofolate4510.8MTRR, MTHFR, MTR, SHMT1, SLC19A1
4methylcobalamin45 2411.8MTRR, MTHFR, MTR, CBS
5cystathionine4510.8MTRR, MTHFD1, MTHFR, MTR, CBS
65,10-methenyltetrahydrofolate4510.8CBS, MTR, MTHFR, MTHFD1
7cobalamin45 2411.8MTRR, MTHFD1, MTHFR, MTR, CBS
8folate4510.8MTRR, MTHFD1, MTHFR, MTR, AFP, SHMT1
9thymidylate4510.8MTRR, MTHFD1, MTHFR, MTR, SHMT1, CBS
1010-formyltetrahydrofolate4510.8MTHFD1, MTHFR, MTR, SLC19A1
11homocysteine45 2411.8MTRR, MTHFD1, MTHFR, MTR, SHMT1, CBS
12methotrexate45 50 1112.8MTRR, MTHFD1, MTHFR, MTR, AFP, SHMT1
13vitamin b64510.8MTHFD1, MTHFR, MTR, SHMT1, CBS
14purine45 2411.8MTHFD1, MTHFR, MTR, SHMT1, CBS, SLC19A1
15betaine45 2411.8MTRR, MTHFR, MTR, CBS
16Tetrahydrofolic acid11 2411.8MTHFD1, MTHFR, MTR, SHMT1
17s-adenosylmethionine45 11 2412.8MTRR, MTHFR, MTR, SHMT1, CBS, SLC19A1
18methylmalonic acid45 2411.8MTRR, MTHFR, MTR, CBS
19vitamin b124510.7MTRR, MTHFR, MTR, AFP, CBS
20methionine4510.7MTRR, MTHFD1, MTHFR, MTR, SHMT1, CBS
21dihydrofolate4510.7MTHFR, MTR, SHMT1, SLC19A1
22cyanocobalamin50 11 2412.7MTRR, MTHFR, MTR
23pyridoxal 5-phosphate4510.7MTHFR, MTR, SHMT1, CBS
24hydroxocobalamin45 1111.7MTRR, MTHFR, MTR
25s-adenosylhomocysteine45 2411.7MTRR, MTHFR, MTR, CBS
26methyl-group4510.7MTR, MTHFR
27cob(ii)alamin45 2411.7MTRR, MTR
28zinc45 2411.6ZIC1, ZIC3, ZIC2, SNAI2, MTR, AFP
29ch2h4folate4510.6MTHFD1, MTHFR
30serine4510.6CBS, AFP
31adenosylcobalamin45 2411.6MTHFR, MTR
32Pyridoxine11 2411.5CBS, MTHFR
33mercaptopurine50 1111.5SLC19A1, MTHFR
34folic acid50 11 2412.5SLC19A1, MTHFR
35L-Methionine11 2411.4MTRR, MTR
36l-serine29 60 11 2413.1CBS, SHMT1

GO Terms for genes affiliated with Neural Tube Defects

Sources:
16Gene Ontology
See all sources

Cellular components related to Neural Tube Defects according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.4FUZ, ZIC3, ZIC2, SNAI2, MTRR, MTHFD1

Biological processes related to Neural Tube Defects according to GeneCards/GeneDecks:

(show all 26)
idNameGO IDScoreTop Affiliating Genes
1neural tube closureGO:00184310.8ALX1, ZIC2, SCRIB, T, VANGL2, FUZ
2establishment of planar polarityGO:00173610.8CELSR1, FUZ, VANGL2
3methionine biosynthetic processGO:00908610.8MTHFR, MTHFD1, MTRR
4folic acid metabolic processGO:04665510.8MTHFD1, MTHFR, SHMT1, SLC19A1
5tetrahydrofolate interconversionGO:03599910.8MTHFD1, MTHFR, SHMT1
6water-soluble vitamin metabolic processGO:00676710.8MTRR, MTHFD1, MTHFR, MTR, SHMT1, SLC19A1
7anterior/posterior pattern specificationGO:00995210.8ZIC3, VANGL2, CELSR1, ALX1
8lateral sprouting involved in lung morphogenesisGO:06049010.8VANGL2, CELSR1
9vitamin metabolic processGO:00676610.8MTRR, MTHFD1, MTHFR, MTR, SHMT1, SLC19A1
10planar dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:06048910.8VANGL2, CELSR1
11sulfur amino acid metabolic processGO:00009610.8CBS, MTR, MTRR
12orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesisGO:06048810.8VANGL2, CELSR1
13establishment of body hair planar orientationGO:04810510.8VANGL2, CELSR1
14hair follicle developmentGO:00194210.7VANGL2, FUZ, CELSR1
15L-serine catabolic processGO:00656510.7CBS, SHMT1
16homocysteine metabolic processGO:05066710.7CBS, MTHFR
17wound healingGO:04206010.7SCRIB, VANGL2, CELSR1
18cellular nitrogen compound metabolic processGO:03464110.7MTRR, MTR, SHMT1, CBS
19apical protein localizationGO:04517610.6CELSR1, VANGL2
20planar cell polarity pathway involved in neural tube closureGO:09017910.6VANGL2, CELSR1
21small molecule metabolic processGO:04428110.6MTRR, MTHFD1, MTHFR, MTR, SHMT1, CBS
22methylationGO:03225910.5MTRR, MTR
23regulation of smoothened signaling pathwayGO:00858910.5FUZ, ZIC1
24cobalamin metabolic processGO:00923510.5MTR, MTRR
25SMAD protein signal transductionGO:06039510.4AFP, T
26post-anal tail morphogenesisGO:03634210.2VANGL2, T

Molecular functions related to Neural Tube Defects according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1modified amino acid bindingGO:07234110.5CBS, MTHFR

Products for genes affiliated with Neural Tube Defects

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neural Tube Defects

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet