MCID: NRL018
MIFTS: 19

Neural Tube Defects, Folate-Sensitive malady

Summaries for Neural Tube Defects, Folate-Sensitive

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46OMIM, 32MalaCards
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MalaCards: Neural Tube Defects, Folate-Sensitive is related to homocysteinemia and megaloblastic anemia. An important gene associated with Neural Tube Defects, Folate-Sensitive is MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase), and among its related pathways are Metabolism of vitamins and cofactors and Metabolism of amino acids and derivatives. The compounds cob(ii)alamin and b vitamins have been mentioned in the context of this disorder.

Description from OMIM:46 601634

Aliases & Classifications for Neural Tube Defects, Folate-Sensitive

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46OMIM
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Aliases & Descriptions:

neural tube defects, folate-sensitive 46


Related Diseases for Neural Tube Defects, Folate-Sensitive

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17GeneCards, 18GeneDecks
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Diseases related to Neural Tube Defects, Folate-Sensitive via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 15)
idRelated DiseaseScoreTop Affiliating Genes
1homocysteinemia10.0MTR
2megaloblastic anemia10.0MTR
3cerebrovascular disease10.0MTR
4thromboembolism10.0MTR
5cleft palate10.0MTR
6coronary heart disease10.0MTR
7disorders of intracellular cobalamin metabolism10.0MTRR, MTR
8homocystinuria10.0MTRR, MTR
9neural tube defects10.0MTR, MTRR
10hyperhomocysteinemia10.0MTRR, MTR
11spina bifida10.0MTR, MTRR
12vascular disease10.0MTR, MTRR
13coronary artery disease10.0MTRR, MTR
14down syndrome10.0MTRR, MTR
15cleft lip10.0MTRR, MTR

Graphical network of diseases related to Neural Tube Defects, Folate-Sensitive:



Diseases related to neural tube defects, folate-sensitive

Clinical Features for Neural Tube Defects, Folate-Sensitive

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46OMIM
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Clinical features from OMIM:

601634

Drugs & Therapeutics for Neural Tube Defects, Folate-Sensitive

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neural Tube Defects, Folate-Sensitive

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Anatomical Context for Neural Tube Defects, Folate-Sensitive

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Animal Models for Neural Tube Defects, Folate-Sensitive or affiliated genes

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Publications for Neural Tube Defects, Folate-Sensitive

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Genetic Variations for Neural Tube Defects, Folate-Sensitive

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Expression for genes affiliated with Neural Tube Defects, Folate-Sensitive

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neural Tube Defects, Folate-Sensitive

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Pathways for genes affiliated with Neural Tube Defects, Folate-Sensitive

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53Reactome, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Neural Tube Defects, Folate-Sensitive

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB
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Compounds related to Neural Tube Defects, Folate-Sensitive according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1cob(ii)alamin44 2410.5MTR, MTRR
2b vitamins449.5MTRR, MTR
3methylcobalamin44 2410.5MTRR, MTR
4hydroxocobalamin44 1110.5MTR, MTRR
5cyanocobalamin49 11 2411.5MTR, MTRR
65-methyltetrahydrofolate44 1110.5MTRR, MTR
7tetrahydrofolate449.4MTR, MTRR
8L-Methionine11 2410.4MTRR, MTR
9betaine44 2410.4MTRR, MTR
10cystathionine449.4MTR, MTRR
11methylmalonic acid44 2410.4MTR, MTRR
12cobalamin44 2410.4MTRR, MTR
13isoleucine449.4MTR, MTRR
14s-adenosylhomocysteine44 2410.4MTR, MTRR
15vitamin b12449.3MTRR, MTR
16thymidylate449.3MTR, MTRR
17homocysteine44 2410.3MTR, MTRR
18s-adenosylmethionine44 11 2411.2MTRR, MTR
19folate449.2MTR, MTRR
20methotrexate44 49 1111.1MTR, MTRR
21aspartate449.1MTR, MTRR
22methionine449.0MTRR, MTR
23nadph44 249.8MTR, MTRR

GO Terms for genes affiliated with Neural Tube Defects, Folate-Sensitive

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16Gene Ontology
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Biological processes related to Neural Tube Defects, Folate-Sensitive according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1methylationGO:0322599.3MTR, MTRR
2cobalamin metabolic processGO:0092359.2MTR, MTRR
3sulfur amino acid metabolic processGO:0000969.2MTR, MTRR
4water-soluble vitamin metabolic processGO:0067679.1MTRR, MTR
5cellular nitrogen compound metabolic processGO:0346419.1MTR, MTRR
6vitamin metabolic processGO:0067669.0MTR, MTRR
7xenobiotic metabolic processGO:0068058.8MTR, MTRR

Products for genes affiliated with Neural Tube Defects, Folate-Sensitive

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  • Antibodies
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Sources for Neural Tube Defects, Folate-Sensitive

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet