MCID: NRL005
MIFTS: 57

Neurilemmoma malady

Rare diseases, Cancer diseases categories
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Summaries for Neurilemmoma

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 A schwannoma is a tumor of the tissue that covers the nerves, called the nerve sheath. these tumors develop from a type of cell called a schwann cell, which gives them their name. schwannomas are often not cancerous (they are typically benign). they can arise from any nerve in the body, although they most often develop in certain nerves located in the head and neck, along with nerves that are involved with flexing in the upper and lower extremities. the most common symptoms of a schwannoma are painless or painful mass that is slow-growing, and electric-like shock when the affected area is felt (tinel shock). the cause of schwannomas is unknown, but they sometimes occur in individuals with certain disorders such as some types of neurofibromatosis. treatment may include surgery, radiotherapy and/or chemotherapy. last updated: 7/5/2011

MalaCards: Neurilemmoma, also known as schwannoma, is related to perineurioma and granular cell tumor. An important gene associated with Neurilemmoma is MYH8 (myosin, heavy chain 8, skeletal muscle, perinatal), and among its related pathways are Striated Muscle Contraction and Neuroscience. The compounds eosin and toluidine have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and thyroid, and related mouse phenotypes are respiratory system and vision/eye.

Wikipedia:65 A schwannoma (also known as an \"neurilemoma,\" \"neuroma,\" \"neurolemoma,\" and \"Schwann cell... more...

Aliases & Classifications for Neurilemmoma

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43NIH Rare Diseases, 62UMLS, 8Disease Ontology, 10DISEASES, 45Novoseek, 35MeSH, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

neurilemmoma 8 10 62
schwannoma 8 43 45
plexiform schwannoma 43 62
cellular schwannoma 43 62
psammomatous schwannoma 8
melanotic neurilemmoma 62
melanotic schwannoma 43
neurilemoma 43
neurinoma 43


External Ids:

Disease Ontology8 DOID:3192
MeSH35 D009442
NCIt40 C3269

Related Diseases for Neurilemmoma

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17GeneCards, 18GeneDecks
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Diseases related to Neurilemmoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 302)
idRelated DiseaseScoreTop Affiliating Genes
1perineurioma30.7VIM, CD34
2granular cell tumor30.4VIM, ENO2
3neurofibroma30.4VIM, NF2, NF1, CD34
4neurofibrosarcoma30.3NF2, NF1
5angiosarcoma30.3VIM, CD34
6gastrointestinal stromal tumor30.3VIM, NF2, NF1, ENO2, CD34
7acoustic neuroma30.2NF1, NF2
8fibroma30.2VIM, CD34
9ependymoma30.1GFAP, VIM, NF2, NF1, ENO2
10meningioma30.1SMARCB1, GFAP, VIM, NF2, NF1, CD34
11leiomyoma30.1VIM, CD34
12sarcoma30.0SMARCB1, VIM, NF2, NF1, B3GAT1, ENO2
13chondrosarcoma30.0ENO2, VIM
14chordoma30.0GFAP, VIM
15malignant peripheral nerve sheath tumor30.0B3GAT1, NF1
16hemangioblastoma29.9GFAP, ENO2
17pilocytic astrocytoma29.9NF1, GFAP
18neurofibromatosis29.9NF1, NF2
19spinal cord ependymoma29.9NF2
20glomus tumor29.9VIM
21hemangioma29.9CD34, NF1
22pleomorphic adenoma29.9VIM, GFAP
23adenocarcinoma29.9VIM, NF2, ENO2, CD34
24choroid plexus papilloma29.8GFAP
25rhabdoid tumor29.8VIM, SMARCB1
26hemangiopericytoma29.8CD34, VIM
27leiomyosarcoma29.8CD34, ENO2, VIM, SMARCB1
28malignant mesothelioma29.8VIM, NF2
29multiple endocrine neoplasia29.8NF1, NF2
30rhabdomyosarcoma29.7SMARCB1, VIM, ENO2
31melanoma29.7VIM, NF2, NF1, ENO2, CD34
32astrocytoma29.7GFAP, VIM, NF2, NF1, B3GAT1
33ganglioglioma29.7GFAP, ENO2
34ganglioneuroma29.7ENO2, GFAP
35paraganglioma29.7GFAP, NF1, ENO2
36glioblastoma multiforme29.6NF1, GFAP, SMARCB1
37retinoblastoma29.6SMARCB1, GFAP, NF1, ENO2
38carney complex10.6
39cervicitis10.5
40myoblastoma10.3
41hydrocephalus10.3
42thyroiditis10.3
43cerebrospinal fluid leak10.3
44banf acoustic neurinoma10.3
45mediastinal neurilemmoma10.3
46melanotic neurilemmoma10.3
47mediastinitis10.2
48peripheral nerve schwannoma10.2
49back pain10.2
50sensorineural hearing loss10.2

Graphical network of the top 20 diseases related to Neurilemmoma:



Diseases related to neurilemmoma

Symptoms for Neurilemmoma

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Drugs & Therapeutics for Neurilemmoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Neurilemmoma

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Genetic Tests for Neurilemmoma

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Anatomical Context for Neurilemmoma

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33MalaCards
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MalaCards organs/tissues related to Neurilemmoma:

33
Tongue, Bone, Thyroid, Breast, Kidney, Tonsil, Lymph node, Cervix, Skin, Testis, Trachea, Ovary, Salivary gland, Lung, Colon, Skeletal muscle, Heart, Spinal cord, Appendix

Animal Models for Neurilemmoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Neurilemmoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6ENO2, NF1, NF2, VIM
2MP:00053918.3SMARCB1, GFAP, VIM, NF2, NF1
3MP:00020068.1SMARCB1, NF2, NF1, CD34
4MP:00053867.8GFAP, VIM, NF2, NF1, B3GAT1, ENO2
5MP:00036317.4ENO2, B3GAT1, NF1, NF2, VIM, GFAP
6MP:00053877.4SMARCB1, GFAP, VIM, NF2, NF1, CD34
7MP:00053847.2SMARCB1, GFAP, VIM, NF1, ENO2, CD34
8MP:00053767.0SMARCB1, GFAP, VIM, NF2, NF1, CD34

Publications for Neurilemmoma

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52PubMed
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Articles related to Neurilemmoma:

(show top 50)    (show all 424)
idTitleAuthorsYear
1
Laparoscopic phrenectomy for a diaphragmatic neurilemmoma. (24250705)
2013
2
Value of ultrasonography in neurilemmoma diagnosis: the role of round shape morphology. (22957323)
2012
3
Giant neurilemmoma of the vagus nerve: a case report and review of literature. (23936960)
2012
4
Wagner-Meissner neurilemmoma of the right cheek. (18486897)
2008
5
Thigh pain due to intraspinal neurilemmoma. (12932385)
2003
6
Cerebral infarction due to carotid occlusion caused by cervical vagal neurilemmoma: report of a case. (11988627)
2002
7
Solitary cellular schwannoma (neurilemmoma) showing malignant changes: evaluation through magnetic resonance imaging (M.R.I.), surgical intervention, and histopathology. (10209928)
1999
8
A painful subcutaneous neurilemmoma attached to a peripheral nerve. (9448222)
1998
9
Intraosseous neurilemmoma of the fibula. (9040146)
1997
10
Jugular foramen neurilemmoma mimicking an intra-axial brainstem tumor--a case report. (8843014)
1996
11
Neurilemmoma of the posterior tibial nerve with an uncommon case presentation. (1619219)
1992
12
Neurilemmoma in the maxillary alveolar bone: report of a case. (1873292)
1991
13
A rare endobronchial neurilemmoma (Schwannoma). (2914500)
1989
14
Polypoid neurilemmoma of the trachea: an unusual cause of major airway obstruction. (3250429)
1988
15
A combined neurilemmoma and angioma of the parasellar region. Case report. (3598695)
1987
16
Pathologic quiz case 2. Neurilemmoma (schwannoma). (3675901)
1987
17
Plexiform neurilemmoma: a clinicopathological and immunohistochemical analysis of 23 tumours from 20 patients. (3114942)
1987
18
Anterior uveal neurilemmoma--a rare neoplasm simulating malignant melanoma. (3545285)
1987
19
Tapia's syndrome caused by a neurilemmoma of vagus and hypoglossal nerves in the neck. (3799257)
1986
20
Gastric neurilemmoma: case report. (3878467)
1985
21
Spinal subdural hematoma, neurilemmoma, and acute transverse myelopathy. (3975824)
1985
22
Epithelioid neurilemmoma of the trigeminal nerve: an immunohistochemical and ultrastructural study. (3913635)
1985
23
Atypical central neurilemmoma of the mandible. (3856819)
1985
24
Mesenchymal differentiation in trigeminal neurilemmoma. (7116288)
1982
25
Regional Multiplicity of a neurilemmoma. (7061018)
1982
26
Neurilemmoma of the pterygo-maxillary fossa. (7229524)
1981
27
Neurilemmoma of optic nerve. (7216356)
1980
28
Neurilemmoma of the vagus nerve. (7212623)
1980
29
Neurilemmoma of the foot: a case report. (762394)
1979
30
Trigger finger due to neurilemmoma in the carpal tunnel. (738662)
1978
31
Retroperitoneal neurilemmoma. (675931)
1978
32
Tarsal-tunnel syndrome caused by neurilemmoma of the medial plantar nerve. A case report. (833162)
1977
33
Endocystography in cystic neurilemmoma. (876448)
1977
34
Neurilemmoma (schwannoma) of the larynx. (1123570)
1975
35
Calcification within a thoracic neurilemmoma. (4444769)
1974
36
Neurilemmoma of the pharynx. (5021025)
1972
37
Intraparotid facial neurilemmoma. (5443951)
1970
38
Malignant neurilemmoma of parotid gland. (5491649)
1970
39
Pulmonary neurilemmoma. (5476293)
1970
40
Neurilemmoma of the cheek. Report of a case. (5230128)
1967
41
NEURILEMMOMA OF THE FACIAL NERVE. (14119586)
1964
42
Neurilemmoma of the cervical sympathetic chain. (14024784)
1963
43
Palpebral neurilemmoma. (14422917)
1960
44
The neurosurgical aspects of seventh nerve neurilemmoma. (13825709)
1960
45
Neurilemmoma of the diaphragm causing severe hypertrophic pulmonary osteoarthropathy. (13560782)
1958
46
Neurilemmoma of the diaphragm. (13320560)
1956
47
Neurilemmoma of the sigmoid colon, associated with diverticulitis as a cause of obstruction. (14388189)
1955
48
Neurilemmoma (Schwannoma) of the larynx. (13136231)
1953
49
Neurilemmoma of pharynx. (12996927)
1952
50
Neurilemmoma of the pharynx. (20266777)
1947

Variations for Neurilemmoma

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Expression for genes affiliated with Neurilemmoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurilemmoma

Search GEO for disease gene expression data for Neurilemmoma.

Pathways for genes affiliated with Neurilemmoma

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50PathCards, 38NCBI BioSystems Database, 55Reactome, 5Cell Signaling Technology, 53QIAGEN
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Pathways related to Neurilemmoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8MYH8, VIM
29.0ENO2, NF2, GFAP
3
Show member pathways
8.7NF1, MYH8, VIM, GFAP

Compounds for genes affiliated with Neurilemmoma

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45Novoseek, 24HMDB, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB
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Compounds related to Neurilemmoma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1eosin4510.0VIM, GFAP
2toluidine4510.0ENO2, VIM
3retinaldehyde4510.0VIM, GFAP
4silicone459.9VIM, GFAP
5streptozotocin459.8VIM, GFAP
6homovanillic acid45 2410.8GFAP, ENO2
72-mercaptoethanol459.8ENO2, GFAP
8spec-t459.7GFAP, ENO2
9fluorochrome459.7VIM, CD34
10s 100459.5GFAP, VIM, ENO2
11ganglioside459.5GFAP, VIM, ENO2
12dbc-amp459.5ENO2, VIM, GFAP
13ganciclovir45 1110.5VIM, GFAP
14cytochalasin d45 6110.5NF1, NF2, VIM
15bromodeoxyuridine459.5ENO2, VIM, GFAP
165-hydroxytryptamine459.5GFAP, VIM, ENO2
17choline45 24 1111.5ENO2, VIM, GFAP
18formaldehyde45 2410.5GFAP, VIM, ENO2
19gaba459.4GFAP, VIM, ENO2
20acth459.4ENO2, B3GAT1, GFAP
21tetrodotoxin45 61 2911.4ENO2, GFAP
22nmda45 2910.4GFAP, VIM, ENO2
23rapamycin459.4NF1, NF2, VIM
24acetylcholine45 51 29 24 1113.4GFAP, VIM, ENO2
25methylcellulose459.4CD34, ENO2
26glycogen45 2410.3GFAP, VIM, ENO2
27methionine459.3GFAP, VIM, NF1
28glutamine459.3ENO2, VIM, GFAP
29iron45 2410.2GFAP, VIM, ENO2
30reticulin459.2CD34, VIM, GFAP
31lactate459.2ENO2, VIM, GFAP
32testosterone45 61 24 1112.1GFAP, VIM, B3GAT1, ENO2
33silver459.0GFAP, ENO2, CD34
34arginine459.0GFAP, VIM, NF1, B3GAT1
35forskolin45 51 1110.9ENO2, NF1, VIM, GFAP
36adenylate458.9GFAP, VIM, NF1, ENO2
37cysteine458.8NF1, NF2, VIM, GFAP
38agar458.8GFAP, VIM, NF2, CD34
39dopamine45 29 24 1111.8GFAP, NF1, ENO2
40atp45 299.8ENO2, NF1, VIM, GFAP
41hematoxylin458.7CD34, ENO2, VIM, GFAP
42vegf458.6CD34, ENO2, VIM, GFAP
43lipid458.6ENO2, NF1, VIM, GFAP
44alanine458.5ENO2, B3GAT1, NF1, VIM, GFAP
45thymidine45 249.3CD34, ENO2, GFAP
46retinoic acid45 249.1GFAP, VIM, NF1, ENO2, CD34
47tyrosine457.9GFAP, NF2, NF1, ENO2, CD34
48estrogen457.7GFAP, VIM, NF1, B3GAT1, ENO2, CD34
49paraffin457.7GFAP, VIM, NF2, NF1, ENO2, CD34
50progesterone45 29 61 24 1111.3CD34, GFAP, VIM, NF2, NF1, B3GAT1

GO Terms for genes affiliated with Neurilemmoma

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16Gene Ontology
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Cellular components related to Neurilemmoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.4CD34, NF1, NF2, MYH8, VIM, GFAP

Biological processes related to Neurilemmoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:0600209.8VIM, GFAP
2astrocyte developmentGO:0140029.8VIM, GFAP
3intermediate filament organizationGO:0451099.8VIM, GFAP
4muscle filament slidingGO:0300499.7MYH8, VIM
5negative regulation of neuron projection developmentGO:0109779.6VIM, GFAP
6negative regulation of cell-matrix adhesionGO:0019539.6NF1, NF2
7negative regulation of MAPK cascadeGO:0434099.5NF2, NF1
8negative regulation of cell migrationGO:0303369.4NF1, NF2
9negative regulation of protein kinase activityGO:0064699.1NF1, NF2

Products for genes affiliated with Neurilemmoma

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Sources for Neurilemmoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet