MCID: NRL005
MIFTS: 55

Neurilemmoma malady

Summaries for Neurilemmoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 A schwannoma is a tumor of the tissue that covers the nerves, called the nerve sheath. these tumors develop from a type of cell called a schwann cell, which gives them their name. schwannomas are often not cancerous (they are typically benign). they can arise from any nerve in the body, although they most often develop in certain nerves located in the head and neck, along with nerves that are involved with flexing in the upper and lower extremities. the most common symptoms of a schwannoma are painless or painful mass that is slow-growing, and electric-like shock when the affected area is felt (tinel shock). the cause of schwannomas is unknown, but they sometimes occur in individuals with certain disorders such as some types of neurofibromatosis. treatment may include surgery, radiotherapy and/or chemotherapy. last updated: 7/5/2011

MalaCards: Neurilemmoma, also known as schwannoma, is related to perineurioma and gastrointestinal stromal tumor. An important gene associated with Neurilemmoma is MYH8 (myosin, heavy chain 8, skeletal muscle, perinatal), and among its related pathways are Striated Muscle Contraction and Spinal Cord Injury. The compounds glycogen and orcein have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and thyroid, and related mouse phenotypes are vision/eye and growth/size.

Wikipedia:63 A schwannoma (also known as an \"neurilemmoma,\" \"neurinoma,\" \"neurolemmoma,\" and \"Schwann cell... more...

Aliases & Classifications for Neurilemmoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

neurilemmoma 8 10 60
schwannoma 8 42 44
plexiform schwannoma 42 60
cellular schwannoma 42 60
psammomatous schwannoma 8
melanotic neurilemmoma 60
melanotic schwannoma 42
neurilemoma 42
neurinoma 42


External Ids:

Disease Ontology8 DOID:3192
NCIt39 C3269
MeSH34 D009442

Related Diseases for Neurilemmoma

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17GeneCards, 18GeneDecks
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Diseases related to Neurilemmoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 319)
idRelated DiseaseScoreTop Affiliating Genes
1perineurioma30.5VIM, CD34, CLDN1
2gastrointestinal stromal tumor30.3ENO2, CD34, NF1, NF2, DES, VIM
3neurofibroma30.3VIM, NF2, NF1, NGFR, CD34
4granular cell tumor30.2ENO2, DES, VIM
5meningioma30.2VIM, NF2, NF1, CD34, GFAP, SMARCB1
6sarcoma30.2VIM, DES, NF2, NF1, CD34, B3GAT1
7neurofibrosarcoma30.2NF2, NF1
8angiosarcoma30.1CD34, VIM
9adenoma30.0ENO2, B3GAT1
10neuroblastoma30.0ENO2, NGFR
11acoustic neuroma30.0NF2, NF1, NGFR
12leiomyoma30.0CD34, DES, VIM
13chordoma30.0VIM, DES, GFAP
14spindle cell sarcoma29.9VIM, DES
15herpes simplex29.9NGFR, NF2
16chondrosarcoma29.9ENO2, DES, VIM
17hemangioblastoma29.9ENO2, GFAP
18adenocarcinoma29.8VIM, NF2, NGFR, CD34, ENO2
19hemangioma29.8CD34, NF1
20neurofibromatosis29.8HGS, NF2, NF1
21oligodendroglioma29.8GFAP
22ganglioneuroma29.8ENO2, GFAP, NGFR
23pleomorphic adenoma29.8GFAP, DES, VIM
24malignant peripheral nerve sheath tumor29.7VIM, NF2, NF1, NGFR, CD34
25leiomyosarcoma29.7SMARCB1, ENO2, CD34, DES, VIM
26breast cancer29.7HGS, NF2, NF1, NGFR, CD34, CLDN1
27astrocytoma29.7VIM, NF2, NF1, NGFR, B3GAT1, GFAP
28melanoma29.7VIM, DES, NF2, NF1, NGFR, CD34
29ossifying fibromyxoid tumor29.6B3GAT1
30glomus tumor29.6VIM, DES
31mesenchymal chondrosarcoma29.6DES, VIM
32choroid plexus papilloma29.6GFAP
33lipoma29.6DES, CD34
34endometrial stromal sarcoma29.6VIM, DES
35malignant mesothelioma29.6VIM, DES, NF2
36ganglioglioma29.6ENO2, GFAP
37hemangiopericytoma29.6VIM, DES, NGFR, CD34
38paraganglioma29.6ENO2, GFAP, NF1
39rhabdomyosarcoma29.6VIM, DES, ENO2, SMARCB1
40glioblastoma multiforme29.6NF1, NGFR, GFAP, SMARCB1
41retinoblastoma29.6NF1, NGFR, GFAP, ENO2, SMARCB1
42carney complex10.6
43cervicitis10.5
44myoblastoma10.3
45hydrocephalus10.3
46sympathetic neurilemmoma10.3
47mediastinal neurilemmoma10.3
48thyroiditis10.3
49banf acoustic neurinoma10.3
50melanotic neurilemmoma10.2

Graphical network of the top 20 diseases related to Neurilemmoma:



Diseases related to neurilemmoma

Clinical Features for Neurilemmoma

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Drugs & Therapeutics for Neurilemmoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neurilemmoma

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Anatomical Context for Neurilemmoma

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32MalaCards
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MalaCards organs/tissues related to Neurilemmoma:

32
Tongue, Bone, Thyroid, Breast, Tonsil, Lymph node, Kidney, Cervix, Skin, Trachea, Testis, Ovary, Salivary gland, Lung, Liver, Colon, Skeletal muscle, Heart, Spinal cord, Appendix

Animal Models for Neurilemmoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neurilemmoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.3VIM, NF2, NF1, NGFR, GFAP, SMARCB1
2MP:00053787.5HGS, NF2, NF1, NGFR, CLDN1, GFAP
3MP:00053857.4VIM, HGS, DES, NF1, NGFR, GFAP
4MP:00053767.2VIM, DES, NF2, NF1, NGFR, CD34
5MP:00053866.6ENO2, VIM, HGS, CRLF1, DES, NF2
6MP:00036316.5VIM, HGS, CRLF1, NF2, NF1, NGFR
7MP:00107686.5CRLF1, VPRBP, HGS, VIM, DES, NF2
8MP:00053846.3VIM, HGS, VPRBP, NF1, NGFR, CD34

Publications for Neurilemmoma

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50PubMed
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Articles related to Neurilemmoma:

(show top 50)    (show all 431)
idTitleAuthorsYear
1
Neurilemmoma (schwannoma) of the thyroid gland: a rare case presentation. (21045459)
2010
2
Intranodal neurilemmoma presenting as parotid mass. (18940018)
2009
3
Fibroadenoma with digital fibroma-like inclusions in neurilemmoma-like stromal component. (18186878)
2008
4
Neurilemmoma of the glans penis: ultrasonography and magnetic resonance imaging findings. (16365576)
2006
5
Dumbbell-shaped cervical spinal neurilemmoma presenting as neck mass. (16354375)
2005
6
Pedunculated neurilemmoma of the tongue base. (15138434)
2004
7
Neurilemmoma of cervical sympathetic chain. (23120053)
2004
8
Neurilemmoma of the diaphragm mimicking a liver tumor: case report. (15160759)
2004
9
Cerebral infarction due to carotid occlusion caused by cervical vagal neurilemmoma: report of a case. (11988627)
2002
10
Neurilemmoma of the Facial Nerve presenting as a Parotid Mass. (23119829)
2001
11
Giant ancient neurilemmoma of the cervical region: report of case. (11381392)
2001
12
Pelvic neurilemmoma. (11505636)
2001
13
Intraosseous neurilemmoma of the mandible. (11110551)
2000
14
Neurilemmoma of the mandible. (10525799)
1999
15
Intrapelvic neurilemmoma presenting with bladder outlet obstruction. (9883240)
1998
16
Intraparotid facial nerve neurilemmoma: a case report. (9581195)
1998
17
Lumbosacral dumb-bell neurilemmoma approached by microsurgical interlaminar foraminotomy. A case report. (8739707)
1996
18
Solitary neurilemmoma of the face. (8720261)
1996
19
Neurilemmoma of the posterior tibial nerve with an uncommon case presentation. (1619219)
1992
20
Isolated olfactory groove neurilemmoma. (1546374)
1992
21
Neurilemmoma of the foot. (2002194)
1991
22
True neurilemmoma arising in a lymph node in infancy. (2010185)
1991
23
Neurilemmoma as a cause of combined thoracic outlet and Horner's syndrome. (1948974)
1991
24
Benign retroperitoneal neurilemmoma--a case report. (2203298)
1990
25
Neurilemmoma of the mandible. (3162970)
1988
26
Tapia's syndrome caused by a neurilemmoma of vagus and hypoglossal nerves in the neck. (3799257)
1986
27
Atypical central neurilemmoma of the mandible. (3856819)
1985
28
CT myelography of calcified thoracic neurilemmoma. (3934940)
1985
29
Benign neurilemmoma in the posterior soft tissues of the right thigh. Case report 325. (4023743)
1985
30
Heterochromia iridis and Horner's syndrome due to paravertebral neurilemmoma. (6823113)
1983
31
Mesenchymal differentiation in trigeminal neurilemmoma. (7116288)
1982
32
Benign orbital neurilemmoma - an uncommon cause of unilateral proptosis. (7187460)
1982
33
Neurilemmoma of the maxillary sinus. (7209299)
1980
34
Neurilemmoma of the parapharyngeal space. Report of three cases and review of the literature. (228048)
1979
35
Malignant parapharyngeal schwannoma (neurilemmoma). (503531)
1979
36
Subarachnoid hemorrhage and papilledema due to a cervical neurilemmoma. Case report. (660234)
1978
37
Tarsal-tunnel syndrome caused by neurilemmoma of the medial plantar nerve. A case report. (833162)
1977
38
Solitary intraosseous neurilemmoma of the tibia: review of intraosseous neurilemmoma and neurofibroma. (1277675)
1976
39
Neurilemmoma of the cervical portion of the vagus nerve: differentiation from a carotid artery aneurysm. (1031438)
1976
40
Acid mucopolysaccharides in tumours of the myelin sheath cells, the oligodendroglioma and the neurilemmoma. (4121721)
1973
41
Neurilemmoma of the facial nerve. (4351600)
1973
42
Development of the vascular system in the hamster malignant neurilemmoma. (4125277)
1973
43
Neurilemmoma of the maxillary antrum. (4700783)
1973
44
Early diagnosis of acoustic nerve neurilemmoma]. (4937411)
1971
45
Neurilemmoma of the bronchus. (4991246)
1970
46
Solitary orbital malignant neurilemmoma. (5642672)
1968
47
Case report: neurilemmoma of the tongue. (5226020)
1967
48
Neurilemmoma of the pharynx. A clinical case report. (6064168)
1967
49
Neurilemmoma of the duodenum. (13892006)
1961
50
A malignant neurilemmoma. (14355268)
1955

Genetic Variations for Neurilemmoma

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Expression for genes affiliated with Neurilemmoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurilemmoma

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Pathways for genes affiliated with Neurilemmoma

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37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Neurilemmoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7MYH8, DES, VIM
29.5GFAP, NGFR, VIM
3
Hide members
9.5GFAP, DES, VIM
48.6NF2, NGFR, GFAP, ENO2
5
Hide members
8.5VIM, DES, NF1, MYH8, NGFR, GFAP

Compounds for genes affiliated with Neurilemmoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB
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Compounds related to Neurilemmoma according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1glycogen44 2411.4GFAP
2orcein4410.2DES, VIM
3eosin4410.2GFAP, VIM
4mucicarmine4410.1DES, VIM
5retinaldehyde4410.0GFAP, VIM
6estrogen4410.0GFAP, NF1
7fluorochrome449.8VIM, CD34
8cytochalasin d44 5910.7VIM, NF2, NF1
9heparan sulfate44 2410.6B3GAT1, DES, VIM
10toluidine449.5VIM, DES, ENO2
11catecholamine449.4VIM, NGFR, ENO2
1212-o-tetradecanoylphorbol 13-acetate449.4VIM, DES, NGFR, CD34
13reticulin449.4GFAP, CD34, DES, VIM
14methionine449.4VIM, DES, NF1, GFAP
15homovanillic acid44 2410.3GFAP, ENO2
165-hydroxytryptamine449.2ENO2, GFAP, VIM
17dbc-amp449.1ENO2, GFAP, NGFR, VIM
18agar449.1GFAP, CD34, NGFR, NF2, VIM
19s 100449.1VIM, DES, GFAP, ENO2
20choline44 11 2411.1ENO2, GFAP, NGFR, VIM
21cyclic amp44 2410.1VIM, DES, NF1, NGFR, GFAP
22gaba449.1ENO2, GFAP, NGFR, VIM
23bromodeoxyuridine449.1VIM, DES, GFAP, ENO2
24formaldehyde44 2410.0VIM, DES, GFAP, ENO2
25arginine449.0VIM, DES, NF1, B3GAT1, GFAP
26nmda44 2810.0ENO2, GFAP, NGFR, VIM
27hyaluronic acid44 2410.0VIM, DES, ENO2
28iron44 249.9VIM, DES, GFAP, ENO2
29lactate448.8VIM, DES, GFAP, ENO2
30silver448.8DES, CD34, GFAP, ENO2
31ganglioside448.8VIM, DES, NGFR, GFAP, ENO2
32acetylcholine44 49 28 11 2412.8VIM, DES, NGFR, GFAP, ENO2
33cysteine448.8VIM, DES, NF2, NF1, NGFR, GFAP
34testosterone44 59 11 2411.7VIM, DES, B3GAT1, GFAP, ENO2
35forskolin44 49 1110.6VIM, NF1, NGFR, GFAP, ENO2
36adenylate448.6VIM, DES, NF1, GFAP, ENO2
37alanine448.5VIM, NF1, B3GAT1, GFAP, ENO2
38dopamine44 28 11 2411.5ENO2, GFAP, NGFR, NF1
39thymidine44 249.5DES, NGFR, CD34, GFAP, ENO2
40hematoxylin448.3ENO2, VIM, DES, NGFR, CD34, GFAP
41retinoic acid44 248.8VIM, DES, NF1, NGFR, CD34, GFAP
42vegf447.6VIM, HGS, DES, NGFR, CD34, GFAP
43paraffin447.5VIM, DES, NF2, NF1, NGFR, CD34
44calcium44 49 11 2410.3DES, NF1, NGFR, CLDN1, B3GAT1, GFAP
45progesterone44 59 28 11 2411.2VIM, DES, NF2, NF1, NGFR, CD34
46tyrosine447.1HGS, DES, NF2, NF1, NGFR, CD34

GO Terms for genes affiliated with Neurilemmoma

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16Gene Ontology
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Cellular components related to Neurilemmoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.5GFAP, DES, VIM

Biological processes related to Neurilemmoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:06002010.0GFAP, VIM
2astrocyte developmentGO:0140029.9GFAP, VIM
3muscle filament slidingGO:0300499.8MYH8, DES, VIM
4intermediate filament organizationGO:0451099.8VIM, GFAP
5negative regulation of JAK-STAT cascadeGO:0464269.6HGS, NF2
6negative regulation of cell-matrix adhesionGO:0019539.6NF2, NF1
7negative regulation of MAPK cascadeGO:0434099.4NF1, NF2
8modulation by virus of host morphology or physiologyGO:0190489.1SMARCB1, CLDN1, VPRBP, VIM

Molecular functions related to Neurilemmoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.5GFAP, DES, VIM

Products for genes affiliated with Neurilemmoma

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Sources for Neurilemmoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet