MCID: NRL005
MIFTS: 55

Neurilemmoma malady

Summaries for Neurilemmoma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 A schwannoma is a tumor of the tissue that covers the nerves, called the nerve sheath. these tumors develop from a type of cell called a schwann cell, which gives them their name. schwannomas are often not cancerous (they are typically benign). they can arise from any nerve in the body, although they most often develop in certain nerves located in the head and neck, along with nerves that are involved with flexing in the upper and lower extremities. the most common symptoms of a schwannoma are painless or painful mass that is slow-growing, and electric-like shock when the affected area is felt (tinel shock). the cause of schwannomas is unknown, but they sometimes occur in individuals with certain disorders such as some types of neurofibromatosis. treatment may include surgery, radiotherapy and/or chemotherapy. last updated: 7/5/2011

MalaCards: Neurilemmoma, also known as schwannoma, is related to perineurioma and gastrointestinal stromal tumor. An important gene associated with Neurilemmoma is MYH8 (myosin, heavy chain 8, skeletal muscle, perinatal), and among its related pathways are Striated Muscle Contraction and Spinal Cord Injury. The compounds glycogen and orcein have been mentioned in the context of this disorder. Affiliated tissues include tongue, thyroid and bone, and related mouse phenotypes are vision/eye and growth/size.

Wikipedia:63 A schwannoma (also known as an \"neurilemmoma,\" \"neurinoma,\" \"neurolemmoma,\" and \"Schwann cell... more...

Aliases & Classifications for Neurilemmoma

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42NIH Rare Diseases, 60UMLS, 8Disease Ontology, 10DISEASES, 44Novoseek, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

neurilemmoma 8 10 60
schwannoma 8 42 44
plexiform schwannoma 42 60
cellular schwannoma 42 60
psammomatous schwannoma 8
melanotic neurilemmoma 60
melanotic schwannoma 42
neurilemoma 42
neurinoma 42


External Ids:

Disease Ontology8 DOID:3192
NCIt39 C3269
MeSH34 D009442

Related Diseases for Neurilemmoma

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17GeneCards, 18GeneDecks
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Diseases related to Neurilemmoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 319)
idRelated DiseaseScoreTop Affiliating Genes
1perineurioma30.5VIM, CD34, CLDN1
2gastrointestinal stromal tumor30.3ENO2, CD34, NF1, NF2, DES, VIM
3neurofibroma30.3VIM, NF2, NF1, NGFR, CD34
4granular cell tumor30.2ENO2, DES, VIM
5meningioma30.2VIM, NF2, NF1, CD34, GFAP, SMARCB1
6sarcoma30.2VIM, DES, NF2, NF1, CD34, B3GAT1
7neurofibrosarcoma30.2NF2, NF1
8angiosarcoma30.1CD34, VIM
9adenoma30.0ENO2, B3GAT1
10neuroblastoma30.0ENO2, NGFR
11acoustic neuroma30.0NF2, NF1, NGFR
12leiomyoma30.0CD34, DES, VIM
13chordoma30.0VIM, DES, GFAP
14spindle cell sarcoma29.9VIM, DES
15herpes simplex29.9NGFR, NF2
16chondrosarcoma29.9ENO2, DES, VIM
17hemangioblastoma29.9ENO2, GFAP
18adenocarcinoma29.8VIM, NF2, NGFR, CD34, ENO2
19hemangioma29.8CD34, NF1
20neurofibromatosis29.8HGS, NF2, NF1
21oligodendroglioma29.8GFAP
22ganglioneuroma29.8ENO2, GFAP, NGFR
23pleomorphic adenoma29.8GFAP, DES, VIM
24malignant peripheral nerve sheath tumor29.7VIM, NF2, NF1, NGFR, CD34
25leiomyosarcoma29.7SMARCB1, ENO2, CD34, DES, VIM
26breast cancer29.7HGS, NF2, NF1, NGFR, CD34, CLDN1
27astrocytoma29.7VIM, NF2, NF1, NGFR, B3GAT1, GFAP
28melanoma29.7VIM, DES, NF2, NF1, NGFR, CD34
29ossifying fibromyxoid tumor29.6B3GAT1
30glomus tumor29.6VIM, DES
31mesenchymal chondrosarcoma29.6DES, VIM
32choroid plexus papilloma29.6GFAP
33lipoma29.6DES, CD34
34endometrial stromal sarcoma29.6VIM, DES
35malignant mesothelioma29.6VIM, DES, NF2
36ganglioglioma29.6ENO2, GFAP
37hemangiopericytoma29.6VIM, DES, NGFR, CD34
38paraganglioma29.6ENO2, GFAP, NF1
39rhabdomyosarcoma29.6VIM, DES, ENO2, SMARCB1
40glioblastoma multiforme29.6NF1, NGFR, GFAP, SMARCB1
41retinoblastoma29.6NF1, NGFR, GFAP, ENO2, SMARCB1
42carney complex10.6
43cervicitis10.5
44myoblastoma10.3
45hydrocephalus10.3
46sympathetic neurilemmoma10.3
47mediastinal neurilemmoma10.3
48thyroiditis10.3
49banf acoustic neurinoma10.3
50melanotic neurilemmoma10.2

Graphical network of the top 20 diseases related to Neurilemmoma:



Diseases related to neurilemmoma

Clinical Features for Neurilemmoma

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Drugs & Therapeutics for Neurilemmoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neurilemmoma

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Anatomical Context for Neurilemmoma

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32MalaCards
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MalaCards organs/tissues related to Neurilemmoma:

32
Tongue, Thyroid, Bone, Breast, Lymph node, Kidney, Tonsil, Cervix, Skin, Salivary gland, Colon, Testis, Trachea, Skeletal muscle, Heart, Lung, Spinal cord, Liver, Ovary, Appendix

Animal Models for Neurilemmoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neurilemmoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.3NF2, NF1, NGFR, GFAP, SMARCB1, VIM
2MP:00053787.5NGFR, GFAP, VIM, HGS, NF2, NF1
3MP:00053857.4DES, GFAP, NGFR, SMARCB1, NF1, HGS
4MP:00053767.2DES, NF1, NGFR, CD34, GFAP, SMARCB1
5MP:00053866.6NF1, NGFR, NF2, ENO2, B3GAT1, CRLF1
6MP:00036316.5NGFR, NF1, CRLF1, NF2, HGS, VIM
7MP:00107686.5GFAP, VIM, HGS, VPRBP, CRLF1, SMARCB1
8MP:00053846.3ENO2, CD34, SMARCB1, GFAP, VIM, HGS

Publications for Neurilemmoma

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50PubMed
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Articles related to Neurilemmoma:

(show top 50)    (show all 431)
idTitleAuthorsYear
1
Lateral cervical approach combined with posterior thoracotomy for the treatment of giant neurilemmoma of the chest involving the neck. (22884113)
2013
2
Intraosseous neurilemmoma of the mandible: report of a rare ancient type. (22013479)
2011
3
Neurilemmoma presenting as a midline nasal mass in a pediatric patient. (20461682)
2010
4
Neurilemmoma of the abdomen. (17699937)
2007
5
Base of tongue neurilemmoma: excision by transoral laser microsurgery. (17712683)
2007
6
Central neurilemmoma of the jaw in concurrence with radicular cyst: a case report. (16997092)
2006
7
Schwannoma (neurilemmoma) of the tongue. (16846930)
2006
8
Malignant transformation of intrathoracic ancient neurilemmoma in a patient without Von Recklinghausen's disease. (12692434)
2003
9
Schwannoma (neurilemmoma) of the facial nerve presenting as a parotid mass. (12389697)
2002
10
Intraosseous schwannoma (neurilemmoma) of the cervical spine. (18521311)
2001
11
Schwannoma (neurilemmoma) of the tonsil. (10605596)
1999
12
Intraosseous neurilemmoma of the lower third of the fibula. (7484619)
1995
13
Tarsal tunnel syndrome secondary to neurilemmoma. (1603612)
1992
14
FNA cytology of thyroid neurilemmoma (schwannoma) (1606890)
1992
15
Intraosseous neurilemmoma of skull--single case report. (1775208)
1991
16
Benign neurilemmoma (schwannoma) masquerading as a pleomorphic adenoma of the submandibular salivary gland. (2555990)
1989
17
Solitary cutaneous plexiform neurilemmoma (schwannoma): a clinicopathologic, immunohistochemical, and ultrastructural study of 11 cases. (2493641)
1989
18
Intrabronchial neurilemmoma--review of cases in Japan. (2694443)
1989
19
A combined neurilemmoma and angioma of the parasellar region. Case report. (3598695)
1987
20
Plexiform neurilemmoma: a clinicopathological and immunohistochemical analysis of 23 tumours from 20 patients. (3114942)
1987
21
Tip of nose: an unusual site for a neurilemmoma. (3779201)
1986
22
Neurilemmoma of the hypoglossal nerve. (3824449)
1986
23
Neurilemmoma of the ciliary body. (6704366)
1984
24
Neurilemmoma of deep branch of ulnar nerve presenting as ulnar tunnel syndrome. (6884854)
1983
25
Neurilemmoma of the foot: a case report. (7240630)
1981
26
Neurilemmoma of orbit. (315927)
1979
27
Central neurilemmoma of the jaws. Review of literature and case report. (100443)
1978
28
Neurilemmoma of tongue. (753893)
1978
29
Peripheral nerve tumour composed of neurilemmoma and haemangioma elements. (676807)
1978
30
Endocystography in cystic neurilemmoma. (876448)
1977
31
Conservation of hearing in acoustic neurilemmoma excision. (408957)
1977
32
Orbital neurilemmoma. Presenting as retrobulbar neuritis. (5428649)
1970
33
Primary neurilemmoma of diaphragm. (5252744)
1969
34
Neurilemmoma of the vagus nerve. (5789452)
1969
35
Neurilemmoma of bone. (5665610)
1968
36
Neurilemmoma within the broad ligament. A case report. (5232054)
1967
37
SOLITARY NEURILEMMOMA OF THE ULNAR NERVE. (14156778)
1964
38
A NEURILEMMOMA OF THE CHOROID. (14147077)
1964
39
Neurilemmoma of the cervical sympathetic chain. (14024784)
1963
40
NEURILEMMOMA OF RIB. REPORT OF A CASE. (14088376)
1963
41
Neurilemmoma of the vagus nerve. (13864357)
1962
42
A case report of neurilemmoma of the fourth rib anteriorly, resembling a breast tumor. (13901986)
1962
43
The neurosurgical aspects of seventh nerve neurilemmoma. (13825709)
1960
44
Tumors of the peripheral nervous system of gynecologic interest: report of a case of a neurilemmoma within the right broad ligament mimicking an ovarian cyst. (13829823)
1959
45
Neurilemmoma (schwannoma) of the retrotonsillar region. (13278648)
1956
46
Neurilemmoma of the sigmoid colon, associated with diverticulitis as a cause of obstruction. (14388189)
1955
47
Neurilemmoma (arising in the hilus of left kidney). (14368700)
1955
48
Neurilemmoma of the stomach with peptic ulceration: report of a case. (14380804)
1955
49
Neurogenic tumour of the stomach: case report of a probable neurilemmoma. (13001574)
1952
50
Gastric neurilemmoma. (14895946)
1951

Genetic Variations for Neurilemmoma

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Expression for genes affiliated with Neurilemmoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurilemmoma

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Pathways for genes affiliated with Neurilemmoma

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37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Neurilemmoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7VIM, DES, MYH8
29.5GFAP, NGFR, VIM
3
Hide members
9.5DES, GFAP, VIM
48.6ENO2, NF2, NGFR, GFAP
5
Hide members
8.5GFAP, NF1, VIM, DES, NGFR, MYH8

Compounds for genes affiliated with Neurilemmoma

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44Novoseek, 24HMDB, 59Tocris Bioscience, 11DrugBank, 28IUPHAR, 49PharmGKB
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Compounds related to Neurilemmoma according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1glycogen44 2411.4GFAP
2orcein4410.2DES, VIM
3eosin4410.2GFAP, VIM
4mucicarmine4410.1DES, VIM
5retinaldehyde4410.0GFAP, VIM
6estrogen4410.0GFAP, NF1
7fluorochrome449.8VIM, CD34
8cytochalasin d44 5910.7VIM, NF2, NF1
9heparan sulfate44 2410.6B3GAT1, DES, VIM
10toluidine449.5VIM, DES, ENO2
11catecholamine449.4VIM, NGFR, ENO2
1212-o-tetradecanoylphorbol 13-acetate449.4VIM, DES, NGFR, CD34
13reticulin449.4GFAP, CD34, DES, VIM
14methionine449.4VIM, DES, NF1, GFAP
15homovanillic acid44 2410.3GFAP, ENO2
165-hydroxytryptamine449.2ENO2, GFAP, VIM
17dbc-amp449.1ENO2, GFAP, NGFR, VIM
18agar449.1GFAP, CD34, NGFR, NF2, VIM
19s 100449.1VIM, DES, GFAP, ENO2
20choline44 11 2411.1ENO2, GFAP, NGFR, VIM
21cyclic amp44 2410.1VIM, DES, NF1, NGFR, GFAP
22gaba449.1ENO2, GFAP, NGFR, VIM
23bromodeoxyuridine449.1VIM, DES, GFAP, ENO2
24formaldehyde44 2410.0VIM, DES, GFAP, ENO2
25arginine449.0VIM, DES, NF1, B3GAT1, GFAP
26nmda44 2810.0ENO2, GFAP, NGFR, VIM
27hyaluronic acid44 2410.0VIM, DES, ENO2
28iron44 249.9VIM, DES, GFAP, ENO2
29lactate448.8VIM, DES, GFAP, ENO2
30silver448.8DES, CD34, GFAP, ENO2
31ganglioside448.8VIM, DES, NGFR, GFAP, ENO2
32acetylcholine44 49 28 11 2412.8VIM, DES, NGFR, GFAP, ENO2
33cysteine448.8VIM, DES, NF2, NF1, NGFR, GFAP
34testosterone44 59 11 2411.7VIM, DES, B3GAT1, GFAP, ENO2
35forskolin44 49 1110.6VIM, NF1, NGFR, GFAP, ENO2
36adenylate448.6VIM, DES, NF1, GFAP, ENO2
37alanine448.5VIM, NF1, B3GAT1, GFAP, ENO2
38dopamine44 28 11 2411.5ENO2, GFAP, NGFR, NF1
39thymidine44 249.5DES, NGFR, CD34, GFAP, ENO2
40hematoxylin448.3ENO2, VIM, DES, NGFR, CD34, GFAP
41retinoic acid44 248.8VIM, DES, NF1, NGFR, CD34, GFAP
42vegf447.6VIM, HGS, DES, NGFR, CD34, GFAP
43paraffin447.5VIM, DES, NF2, NF1, NGFR, CD34
44calcium44 49 11 2410.3DES, NF1, NGFR, CLDN1, B3GAT1, GFAP
45progesterone44 59 28 11 2411.2VIM, DES, NF2, NF1, NGFR, CD34
46tyrosine447.1HGS, DES, NF2, NF1, NGFR, CD34

GO Terms for genes affiliated with Neurilemmoma

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16Gene Ontology
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Cellular components related to Neurilemmoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.5GFAP, DES, VIM

Biological processes related to Neurilemmoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:06002010.0GFAP, VIM
2astrocyte developmentGO:0140029.9GFAP, VIM
3muscle filament slidingGO:0300499.8MYH8, DES, VIM
4intermediate filament organizationGO:0451099.8VIM, GFAP
5negative regulation of JAK-STAT cascadeGO:0464269.6HGS, NF2
6negative regulation of cell-matrix adhesionGO:0019539.6NF2, NF1
7negative regulation of MAPK cascadeGO:0434099.4NF1, NF2
8modulation by virus of host morphology or physiologyGO:0190489.1SMARCB1, CLDN1, VPRBP, VIM

Molecular functions related to Neurilemmoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.5GFAP, DES, VIM

Products for genes affiliated with Neurilemmoma

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Sources for Neurilemmoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet