MCID: NRL005
MIFTS: 57

Neurilemmoma malady

Rare diseases, Cancer diseases categories

Summaries for Neurilemmoma

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 A schwannoma is a tumor of the tissue that covers the nerves, called the nerve sheath. these tumors develop from a type of cell called a schwann cell, which gives them their name. schwannomas are often not cancerous (they are typically benign). they can arise from any nerve in the body, although they most often develop in certain nerves located in the head and neck, along with nerves that are involved with flexing in the upper and lower extremities.Ā the most common symptoms of a schwannoma are painless or painful mass that is slow-growing, and electric-like shock when the affected area is felt (tinel shock). the cause of schwannomasĀ is unknown, but they sometimes occur in individuals with certain disorders such as some types ofĀ neurofibromatosis. treatment may include surgery, radiotherapy and/or chemotherapy. last updated: 7/5/2011

MalaCards: Neurilemmoma, also known as schwannoma, is related to perineurioma and granular cell tumor. An important gene associated with Neurilemmoma is MYH8 (myosin, heavy chain 8, skeletal muscle, perinatal), and among its related pathways are Striated Muscle Contraction and Neuroscience. The compounds eosin and toluidine have been mentioned in the context of this disorder. Affiliated tissues include tongue, bone and thyroid, and related mouse phenotypes are respiratory system and vision/eye.

Wikipedia:66 A schwannoma (also known as an \"neurilemoma,\" \"neuroma,\" \"neurolemoma,\" and \"Schwann cell... more...

Aliases & Classifications for Neurilemmoma

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44NIH Rare Diseases, 63UMLS, 9Disease Ontology, 11DISEASES, 46Novoseek, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Aliases & Descriptions:

neurilemmoma 9 11 63
schwannoma 9 44 46
plexiform schwannoma 44 63
cellular schwannoma 44 63
psammomatous schwannoma 9
melanotic neurilemmoma 63
melanotic schwannoma 44
neurilemoma 44
neurinoma 44


External Ids:

Disease Ontology9 DOID:3192
MeSH36 D009442
NCIt41 C3269

Related Diseases for Neurilemmoma

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18GeneCards, 19GeneDecks
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Diseases related to Neurilemmoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 302)
idRelated DiseaseScoreTop Affiliating Genes
1perineurioma30.7VIM, CD34
2granular cell tumor30.4VIM, ENO2
3neurofibroma30.4VIM, NF2, NF1, CD34
4neurofibrosarcoma30.3NF2, NF1
5angiosarcoma30.3VIM, CD34
6gastrointestinal stromal tumor30.3VIM, NF2, NF1, ENO2, CD34
7acoustic neuroma30.2NF1, NF2
8fibroma30.2VIM, CD34
9ependymoma30.1GFAP, VIM, NF2, NF1, ENO2
10meningioma30.1SMARCB1, GFAP, VIM, NF2, NF1, CD34
11leiomyoma30.1VIM, CD34
12sarcoma30.0SMARCB1, VIM, NF2, NF1, B3GAT1, ENO2
13chondrosarcoma30.0ENO2, VIM
14chordoma30.0GFAP, VIM
15malignant peripheral nerve sheath tumor30.0B3GAT1, NF1
16hemangioblastoma29.9GFAP, ENO2
17pilocytic astrocytoma29.9NF1, GFAP
18neurofibromatosis29.9NF1, NF2
19spinal cord ependymoma29.9NF2
20glomus tumor29.9VIM
21hemangioma29.9CD34, NF1
22pleomorphic adenoma29.9VIM, GFAP
23adenocarcinoma29.9VIM, NF2, ENO2, CD34
24choroid plexus papilloma29.8GFAP
25rhabdoid tumor29.8VIM, SMARCB1
26hemangiopericytoma29.8CD34, VIM
27leiomyosarcoma29.8CD34, ENO2, VIM, SMARCB1
28malignant mesothelioma29.8VIM, NF2
29multiple endocrine neoplasia29.8NF1, NF2
30rhabdomyosarcoma29.7SMARCB1, VIM, ENO2
31melanoma29.7VIM, NF2, NF1, ENO2, CD34
32astrocytoma29.7GFAP, VIM, NF2, NF1, B3GAT1
33ganglioglioma29.7GFAP, ENO2
34ganglioneuroma29.7ENO2, GFAP
35paraganglioma29.7GFAP, NF1, ENO2
36glioblastoma multiforme29.6NF1, GFAP, SMARCB1
37retinoblastoma29.6SMARCB1, GFAP, NF1, ENO2
38carney complex10.6
39cervicitis10.5
40myoblastoma10.3
41hydrocephalus10.3
42thyroiditis10.3
43cerebrospinal fluid leak10.3
44banf acoustic neurinoma10.3
45mediastinal neurilemmoma10.3
46melanotic neurilemmoma10.3
47mediastinitis10.2
48peripheral nerve schwannoma10.2
49back pain10.2
50sensorineural hearing loss10.2

Graphical network of the top 20 diseases related to Neurilemmoma:



Diseases related to neurilemmoma

Symptoms for Neurilemmoma

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Drugs & Therapeutics for Neurilemmoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neurilemmoma

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Anatomical Context for Neurilemmoma

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34MalaCards
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MalaCards organs/tissues related to Neurilemmoma:

34
Tongue, Bone, Thyroid, Breast, Kidney, Tonsil, Lymph node, Cervix, Skin, Testis, Trachea, Ovary, Salivary gland, Lung, Colon, Skeletal muscle, Heart, Spinal cord, Appendix

Animal Models for Neurilemmoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Neurilemmoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.6ENO2, NF1, NF2, VIM
2MP:00053918.3SMARCB1, GFAP, VIM, NF2, NF1
3MP:00020068.1SMARCB1, NF2, NF1, CD34
4MP:00053867.8GFAP, VIM, NF2, NF1, B3GAT1, ENO2
5MP:00036317.4ENO2, B3GAT1, NF1, NF2, VIM, GFAP
6MP:00053877.4SMARCB1, GFAP, VIM, NF2, NF1, CD34
7MP:00053847.2SMARCB1, GFAP, VIM, NF1, ENO2, CD34
8MP:00053767.0SMARCB1, GFAP, VIM, NF2, NF1, CD34

Publications for Neurilemmoma

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53PubMed
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Articles related to Neurilemmoma:

(show top 50)    (show all 424)
idTitleAuthorsYear
1
Laparoscopic phrenectomy for a diaphragmatic neurilemmoma. (24250705)
2013
2
Value of ultrasonography in neurilemmoma diagnosis: the role of round shape morphology. (22957323)
2012
3
Giant neurilemmoma of the vagus nerve: a case report and review of literature. (23936960)
2012
4
Wagner-Meissner neurilemmoma of the right cheek. (18486897)
2008
5
Thigh pain due to intraspinal neurilemmoma. (12932385)
2003
6
Cerebral infarction due to carotid occlusion caused by cervical vagal neurilemmoma: report of a case. (11988627)
2002
7
Solitary cellular schwannoma (neurilemmoma) showing malignant changes: evaluation through magnetic resonance imaging (M.R.I.), surgical intervention, and histopathology. (10209928)
1999
8
A painful subcutaneous neurilemmoma attached to a peripheral nerve. (9448222)
1998
9
Intraosseous neurilemmoma of the fibula. (9040146)
1997
10
Jugular foramen neurilemmoma mimicking an intra-axial brainstem tumor--a case report. (8843014)
1996
11
Neurilemmoma of the posterior tibial nerve with an uncommon case presentation. (1619219)
1992
12
Neurilemmoma in the maxillary alveolar bone: report of a case. (1873292)
1991
13
A rare endobronchial neurilemmoma (Schwannoma). (2914500)
1989
14
Polypoid neurilemmoma of the trachea: an unusual cause of major airway obstruction. (3250429)
1988
15
A combined neurilemmoma and angioma of the parasellar region. Case report. (3598695)
1987
16
Pathologic quiz case 2. Neurilemmoma (schwannoma). (3675901)
1987
17
Plexiform neurilemmoma: a clinicopathological and immunohistochemical analysis of 23 tumours from 20 patients. (3114942)
1987
18
Anterior uveal neurilemmoma--a rare neoplasm simulating malignant melanoma. (3545285)
1987
19
Tapia's syndrome caused by a neurilemmoma of vagus and hypoglossal nerves in the neck. (3799257)
1986
20
Gastric neurilemmoma: case report. (3878467)
1985
21
Spinal subdural hematoma, neurilemmoma, and acute transverse myelopathy. (3975824)
1985
22
Epithelioid neurilemmoma of the trigeminal nerve: an immunohistochemical and ultrastructural study. (3913635)
1985
23
Atypical central neurilemmoma of the mandible. (3856819)
1985
24
Mesenchymal differentiation in trigeminal neurilemmoma. (7116288)
1982
25
Regional Multiplicity of a neurilemmoma. (7061018)
1982
26
Neurilemmoma of the pterygo-maxillary fossa. (7229524)
1981
27
Neurilemmoma of optic nerve. (7216356)
1980
28
Neurilemmoma of the vagus nerve. (7212623)
1980
29
Neurilemmoma of the foot: a case report. (762394)
1979
30
Trigger finger due to neurilemmoma in the carpal tunnel. (738662)
1978
31
Retroperitoneal neurilemmoma. (675931)
1978
32
Tarsal-tunnel syndrome caused by neurilemmoma of the medial plantar nerve. A case report. (833162)
1977
33
Endocystography in cystic neurilemmoma. (876448)
1977
34
Neurilemmoma (schwannoma) of the larynx. (1123570)
1975
35
Calcification within a thoracic neurilemmoma. (4444769)
1974
36
Neurilemmoma of the pharynx. (5021025)
1972
37
Intraparotid facial neurilemmoma. (5443951)
1970
38
Malignant neurilemmoma of parotid gland. (5491649)
1970
39
Pulmonary neurilemmoma. (5476293)
1970
40
Neurilemmoma of the cheek. Report of a case. (5230128)
1967
41
NEURILEMMOMA OF THE FACIAL NERVE. (14119586)
1964
42
Neurilemmoma of the cervical sympathetic chain. (14024784)
1963
43
Palpebral neurilemmoma. (14422917)
1960
44
The neurosurgical aspects of seventh nerve neurilemmoma. (13825709)
1960
45
Neurilemmoma of the diaphragm causing severe hypertrophic pulmonary osteoarthropathy. (13560782)
1958
46
Neurilemmoma of the diaphragm. (13320560)
1956
47
Neurilemmoma of the sigmoid colon, associated with diverticulitis as a cause of obstruction. (14388189)
1955
48
Neurilemmoma (Schwannoma) of the larynx. (13136231)
1953
49
Neurilemmoma of pharynx. (12996927)
1952
50
Neurilemmoma of the pharynx. (20266777)
1947

Variations for Neurilemmoma

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Expression for genes affiliated with Neurilemmoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurilemmoma

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Pathways for genes affiliated with Neurilemmoma

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51PathCards, 39NCBI BioSystems Database, 56Reactome, 5Cell Signaling Technology, 54QIAGEN
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Pathways related to Neurilemmoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8MYH8, VIM
29.0ENO2, NF2, GFAP
3
Show member pathways
8.7NF1, MYH8, VIM, GFAP

Compounds for genes affiliated with Neurilemmoma

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46Novoseek, 25HMDB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB
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Compounds related to Neurilemmoma according to GeneCards/GeneDecks:

(show top 50)    (show all 56)
idCompoundScoreTop Affiliating Genes
1eosin4610.0VIM, GFAP
2toluidine4610.0ENO2, VIM
3retinaldehyde4610.0VIM, GFAP
4silicone469.9VIM, GFAP
5streptozotocin469.8VIM, GFAP
6homovanillic acid46 2510.8GFAP, ENO2
72-mercaptoethanol469.8ENO2, GFAP
8spec-t469.7GFAP, ENO2
9fluorochrome469.7VIM, CD34
10s 100469.5GFAP, VIM, ENO2
11ganglioside469.5GFAP, VIM, ENO2
12dbc-amp469.5ENO2, VIM, GFAP
13ganciclovir46 1210.5VIM, GFAP
14cytochalasin d46 6210.5NF1, NF2, VIM
15bromodeoxyuridine469.5ENO2, VIM, GFAP
165-hydroxytryptamine469.5GFAP, VIM, ENO2
17choline46 25 1211.5ENO2, VIM, GFAP
18formaldehyde46 2510.5GFAP, VIM, ENO2
19gaba469.4GFAP, VIM, ENO2
20acth469.4ENO2, B3GAT1, GFAP
21tetrodotoxin46 62 3011.4ENO2, GFAP
22nmda46 3010.4GFAP, VIM, ENO2
23rapamycin469.4NF1, NF2, VIM
24acetylcholine46 52 30 25 1213.4GFAP, VIM, ENO2
25methylcellulose469.4CD34, ENO2
26glycogen46 2510.3GFAP, VIM, ENO2
27methionine469.3GFAP, VIM, NF1
28glutamine469.3ENO2, VIM, GFAP
29iron46 2510.2GFAP, VIM, ENO2
30reticulin469.2CD34, VIM, GFAP
31lactate469.2ENO2, VIM, GFAP
32testosterone46 62 25 1212.1GFAP, VIM, B3GAT1, ENO2
33silver469.0GFAP, ENO2, CD34
34arginine469.0GFAP, VIM, NF1, B3GAT1
35forskolin46 52 1210.9ENO2, NF1, VIM, GFAP
36adenylate468.9GFAP, VIM, NF1, ENO2
37cysteine468.8NF1, NF2, VIM, GFAP
38agar468.8GFAP, VIM, NF2, CD34
39dopamine46 30 25 1211.8GFAP, NF1, ENO2
40atp46 309.8ENO2, NF1, VIM, GFAP
41hematoxylin468.7CD34, ENO2, VIM, GFAP
42vegf468.6CD34, ENO2, VIM, GFAP
43lipid468.6ENO2, NF1, VIM, GFAP
44alanine468.5ENO2, B3GAT1, NF1, VIM, GFAP
45thymidine46 259.3CD34, ENO2, GFAP
46retinoic acid46 259.1GFAP, VIM, NF1, ENO2, CD34
47tyrosine467.9GFAP, NF2, NF1, ENO2, CD34
48estrogen467.7GFAP, VIM, NF1, B3GAT1, ENO2, CD34
49paraffin467.7GFAP, VIM, NF2, NF1, ENO2, CD34
50progesterone46 30 62 25 1211.3CD34, GFAP, VIM, NF2, NF1, B3GAT1

GO Terms for genes affiliated with Neurilemmoma

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17Gene Ontology
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Cellular components related to Neurilemmoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057377.4CD34, NF1, NF2, MYH8, VIM, GFAP

Biological processes related to Neurilemmoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:0600209.8VIM, GFAP
2astrocyte developmentGO:0140029.8VIM, GFAP
3intermediate filament organizationGO:0451099.8VIM, GFAP
4muscle filament slidingGO:0300499.7MYH8, VIM
5negative regulation of neuron projection developmentGO:0109779.6VIM, GFAP
6negative regulation of cell-matrix adhesionGO:0019539.6NF1, NF2
7negative regulation of MAPK cascadeGO:0434099.5NF2, NF1
8negative regulation of cell migrationGO:0303369.4NF1, NF2
9negative regulation of protein kinase activityGO:0064699.1NF1, NF2

Products for genes affiliated with Neurilemmoma

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Sources for Neurilemmoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet