MCID: NRL005
MIFTS: 49

Neurilemmoma malady

Summaries for Neurilemmoma

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 A schwannoma is a tumor of the tissue that covers the nerves, called the nerve sheath. these tumors develop from a type of cell called a schwann cell, which gives them their name. schwannomas are often not cancerous (they are typically benign). they can arise from any nerve in the body, although they most often develop in certain nerves located in the head and neck, along with nerves that are involved with flexing in the upper and lower extremities. the most common symptoms of a schwannoma are painless or painful mass that is slow-growing, and electric-like shock when the affected area is felt (tinel shock). the cause of schwannomas is unknown, but they sometimes occur in individuals with certain disorders such as some types of neurofibromatosis. treatment may include surgery, radiotherapy and/or chemotherapy. last updated: 7/5/2011

MalaCards: Neurilemmoma, also known as schwannoma, is related to gastrointestinal stromal tumor and granular cell tumor. An important gene associated with Neurilemmoma is MYH8 (myosin, heavy chain 8, skeletal muscle, perinatal), and among its related pathways are Striated Muscle Contraction and Spinal Cord Injury. The compounds glycogen and orcein have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and growth/size.

Wikipedia:64 A schwannoma (also known as an \"neurilemmoma,\" \"neurinoma,\" \"neurolemmoma,\" and \"Schwann cell... more...

Aliases & Classifications for Neurilemmoma

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

neurilemmoma 8 10 61
schwannoma 8 43 45
plexiform schwannoma 43 61
cellular schwannoma 43 61
psammomatous schwannoma 8
melanotic neurilemmoma 61
melanotic schwannoma 43
neurilemoma 43
neurinoma 43


External Ids:

Disease Ontology8 DOID:3192
NCIt40 C3269
MeSH35 D009442

Related Diseases for Neurilemmoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neurilemmoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 278)
idRelated DiseaseScoreTop Affiliating Genes
1gastrointestinal stromal tumor30.3VIM, NF1, NF2, CD34, ENO2, DES
2granular cell tumor30.3ENO2, DES, VIM
3ependymoma30.2VIM, ENO2, GFAP, NGFR, NF1, NF2
4angiosarcoma30.2VIM, CD34
5neurofibrosarcoma30.2NF1, NF2
6adenoma30.1ENO2, B3GAT1
7acoustic neuroma30.1NF2, NF1, NGFR
8spindle cell sarcoma29.9DES, VIM
9adenocarcinoma29.9NGFR, NF2, CD34, ENO2, VIM
10wilms tumor29.9VIM, ENO2, DES, SMARCB1
11neurofibromatosis29.8NF1, HGS, NF2
12ganglioneuroma29.8ENO2, GFAP, NGFR
13pleomorphic adenoma29.8VIM, DES, GFAP
14astrocytoma29.8B3GAT1, NF2, NF1, NGFR, VIM, GFAP
15ossifying fibromyxoid tumor29.7B3GAT1
16choroid plexus papilloma29.7GFAP
17endometrial stromal sarcoma29.7DES, VIM
18ganglioglioma29.7ENO2, GFAP
19rhabdoid tumor29.7SMARCB1, DES, VIM
20paraganglioma29.7ENO2, NF1, GFAP
21n syndrome10.4
22carney complex10.4
23myoblastoma10.3
24sympathetic neurilemmoma10.3
25plexiform neurofibroma10.3
26cerebrospinal fluid leak10.3
27banf acoustic neurinoma10.3
28benign schwannoma10.3
29cerebellopontine angle meningioma10.2
30epithelioid malignant peripheral nerve sheath tumor10.2
31myxoma-spotty pigmentation-endocrine overactivity10.2
32sensorineural hearing loss10.2
33carotid body tumor10.2
34tarsal tunnel syndrome10.2
35plexiform schwannoma10.2
36neurilemmoma of the fifth cranial nerve10.2
37neurilemmomatosis10.2
38myoma10.1
39schwannoma of twelfth cranial nerve10.1
40benign peripheral nerve sheath tumor10.1
41solitary fibrous tumor10.1
42benign dermal neurilemmoma10.1
43cellular schwannoma10.1
44macrocystic neurilemmoma10.1
45neurilemmoma of the pleura10.1
46benign mediastinal psammomatous neurilemmoma10.1
47mediastinal melanocytic neurilemmoma10.1
48thoracic outlet syndrome10.1
49horner's syndrome10.1
50benign mediastinal neurilemmoma10.1

Graphical network of the top 20 diseases related to Neurilemmoma:



Diseases related to neurilemmoma

Clinical Features for Neurilemmoma

Drugs & Therapeutics for Neurilemmoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Neurilemmoma

Drug clinical trials:

Search ClinicalTrials for Neurilemmoma

Search NIH Clinical Center for Neurilemmoma

Search CenterWatch for Neurilemmoma

Genetic Tests for Neurilemmoma

Anatomical Context for Neurilemmoma

Animal Models for Neurilemmoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Neurilemmoma

Sources:
51PubMed
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Articles related to Neurilemmoma:

(show top 50)    (show all 438)
idTitleAuthorsYear
1
Value of ultrasonography in neurilemmoma diagnosis: the role of round shape morphology. (22957323)
2012
2
Mandible schwannoma (neurilemmoma) presenting as periapical lesion. (19225090)
2009
3
Intranodal neurilemmoma presenting as parotid mass. (18940018)
2009
4
Multinodular neurilemmoma of the tongue: a case report with differential immunohistochemical profile. (18427374)
2008
5
Pelvic neurilemmoma. (11505636)
2001
6
Tracheal neurilemmoma mimicking bronchial asthma--a dilemma of difficult diagnosis: case report. (10584430)
1999
7
Lateral thyrotomy for neurilemmoma of the larynx. (10474670)
1999
8
CT features of retroperitoneal neurilemmoma. (9587770)
1998
9
Lumbosacral dumb-bell neurilemmoma approached by microsurgical interlaminar foraminotomy. A case report. (8739707)
1996
10
Solitary neurilemmoma of the face. (8720261)
1996
11
Cystic spinal neurilemmoma on magnetic resonance imaging. (1407534)
1992
12
Isolated olfactory groove neurilemmoma. (1546374)
1992
13
Facial nerve neurilemmoma: report of four cases. (1685167)
1991
14
Neurilemmoma as a cause of combined thoracic outlet and Horner's syndrome. (1948974)
1991
15
Unusual presentation of neurilemmoma in the cerebellopontine angle. (2787826)
1989
16
Neurilemmoma involving the maxillary sinus: a case report. (2597661)
1989
17
Neurilemmoma of the vagus nerve in the neck. (2721408)
1989
18
Neurilemmoma of the mandible. (3162970)
1988
19
Benign neurilemmoma in the posterior soft tissues of the right thigh. Case report 325. (4023743)
1985
20
Case of the month. Neurilemmoma. (6590636)
1984
21
A solitary neurilemmoma of the clitoris. (6822362)
1983
22
Recurrence of benign orbital neurilemmoma (schwannoma) after 22 years. (7165843)
1982
23
Hypoglossal neurilemmoma: case report and review of the literature. (7099413)
1982
24
Neurilemmoma of the pterygo-maxillary fossa. (7229524)
1981
25
Ultrastructure of capillaries in acoustic neurilemmoma. (7280969)
1981
26
Neurilemmoma of optic nerve. (7216356)
1980
27
Multicentric thyroid carcinoma, parathyroid adenomas, and vagal neurilemmoma in a young man with antecedent tonsillar radiation. (7412405)
1980
28
Acoustic neurilemmoma. Clinicoanatomical study of 103 patients. (7350277)
1980
29
Trigeminal neurilemmoma presenting as a sphenoid sinus mass. (441918)
1979
30
Neurilemmoma of the lateral plantar nerve: a case report. (690384)
1978
31
Pelvic neurilemmoma. Report of a case, electron microscopic studies and review of the literature. (590861)
1977
32
Parapharyngeal neurilemmoma of the hypoglossal nerve. (933662)
1976
33
Neurilemmoma (schwannoma) of the larynx. (1123570)
1975
34
Neurilemmoma of the palate. (1126433)
1975
35
Intralabyrinthine neurilemmoma. A histopathological report. (4675702)
1972
36
Intraspinal neurilemmomas simulating lumbar disc disease. (5545418)
1971
37
Neurilemmoma of tongue. (5581366)
1971
38
Neurilemmoma of the bronchus. (4991246)
1970
39
Intracranial neurilemmoma of the hypoglossal nerve. Review and case report. (5949437)
1966
40
NEURILEMMOMA OF THE PERINEUM. (14334310)
1965
41
CONGENITAL MALIGNANT NEURILEMMOMA. (14149936)
1964
42
INTRAPETROUS NEURILEMMOMA. REPORT OF TWO CASES AND REVIEW OF THE SURGICAL ANATOMY. (14214212)
1964
43
Intramedullary neurilemmoma (neurinoma) of the thoracic cord. A case report. (13909951)
1962
44
A neurilemmoma of the larynx. (13908293)
1961
45
A large mediastinal neurilemmoma associated with peptic ulcer and melena. (13920870)
1961
46
Palpebral neurilemmoma. (14422917)
1960
47
Neurilemmoma of 10th dorsal nerve. Presenting as an acute abdomen. (14419304)
1960
48
Neurilemmoma of the hypoglossal nerve: report of a case. (13636604)
1959
49
Neurilemmoma of the diaphragm. (13320560)
1956
50
Neurilemmoma of the orbit. (13364186)
1956

Genetic Variations for Neurilemmoma

Expression for genes affiliated with Neurilemmoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurilemmoma

Search GEO for disease gene expression data for Neurilemmoma.

Pathways for genes affiliated with Neurilemmoma

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 4Cell Signaling Technology, 52QIAGEN
See all sources

Pathways related to Neurilemmoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7VIM, DES, MYH8
29.5GFAP, NGFR, VIM
3
Hide members
9.5DES, GFAP, VIM
48.6ENO2, NF2, NGFR, GFAP
5
Hide members
8.5GFAP, NF1, VIM, DES, NGFR, MYH8

Compounds for genes affiliated with Neurilemmoma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 11DrugBank, 29IUPHAR, 50PharmGKB
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Compounds related to Neurilemmoma according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1glycogen45 2411.4GFAP
2orcein4510.2DES, VIM
3eosin4510.2GFAP, VIM
4mucicarmine4510.1DES, VIM
5retinaldehyde4510.0VIM, GFAP
6estrogen4510.0NF1, GFAP
7fluorochrome459.8CD34, VIM
8cytochalasin d45 6010.7VIM, NF2, NF1
9heparan sulfate45 2410.6B3GAT1, DES, VIM
10toluidine459.5DES, ENO2, VIM
11catecholamine459.4VIM, ENO2, NGFR
1212-o-tetradecanoylphorbol 13-acetate459.4VIM, DES, CD34, NGFR
13reticulin459.4DES, GFAP, CD34, VIM
14methionine459.4DES, GFAP, NF1, VIM
15homovanillic acid45 2410.3ENO2, GFAP
165-hydroxytryptamine459.2ENO2, VIM, GFAP
17dbc-amp459.1VIM, GFAP, ENO2, NGFR
18agar459.1GFAP, VIM, NF2, NGFR, CD34
19s 100459.1DES, GFAP, ENO2, VIM
20choline45 11 2411.1NGFR, VIM, GFAP, ENO2
21cyclic amp45 2410.1VIM, DES, NF1, NGFR, GFAP
22gaba459.1VIM, GFAP, ENO2, NGFR
23bromodeoxyuridine459.1VIM, GFAP, ENO2, DES
24formaldehyde45 2410.0ENO2, GFAP, VIM, DES
25arginine459.0GFAP, NF1, DES, B3GAT1, VIM
26nmda45 2910.0ENO2, GFAP, NGFR, VIM
27hyaluronic acid45 2410.0DES, ENO2, VIM
28iron45 249.9GFAP, DES, VIM, ENO2
29lactate458.8VIM, DES, GFAP, ENO2
30silver458.8DES, CD34, GFAP, ENO2
31ganglioside458.8VIM, DES, NGFR, ENO2, GFAP
32acetylcholine45 50 29 11 2412.8VIM, DES, NGFR, GFAP, ENO2
33cysteine458.8NGFR, DES, NF1, NF2, VIM, GFAP
34testosterone45 60 11 2411.7ENO2, GFAP, B3GAT1, DES, VIM
35forskolin45 50 1110.6VIM, NF1, NGFR, GFAP, ENO2
36adenylate458.6VIM, NF1, ENO2, GFAP, DES
37alanine458.5B3GAT1, VIM, NF1, GFAP, ENO2
38dopamine45 29 11 2411.5NGFR, NF1, ENO2, GFAP
39thymidine45 249.5DES, CD34, GFAP, ENO2, NGFR
40hematoxylin458.3NGFR, DES, VIM, ENO2, GFAP, CD34
41retinoic acid45 248.8GFAP, DES, VIM, CD34, NF1, ENO2
42vegf457.6GFAP, CD34, NGFR, DES, ENO2, HGS
43paraffin457.5VIM, NF2, NF1, NGFR, CD34, GFAP
44calcium45 50 11 2410.3DES, NF1, NGFR, CLDN1, B3GAT1, GFAP
45progesterone45 60 29 11 2411.2NGFR, VIM, DES, NF2, NF1, ENO2
46tyrosine457.1DES, NGFR, NF2, NF1, HGS, CD34

GO Terms for genes affiliated with Neurilemmoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Neurilemmoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.5GFAP, DES, VIM

Biological processes related to Neurilemmoma according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:06002010.0GFAP, VIM
2astrocyte developmentGO:0140029.9VIM, GFAP
3muscle filament slidingGO:0300499.8DES, VIM, MYH8
4intermediate filament organizationGO:0451099.7VIM, GFAP
5negative regulation of cell-matrix adhesionGO:0019539.7NF1, NF2
6negative regulation of JAK-STAT cascadeGO:0464269.6HGS, NF2
7negative regulation of MAPK cascadeGO:0434099.4NF2, NF1
8modulation by virus of host morphology or physiologyGO:0190489.1SMARCB1, VIM, VPRBP, CLDN1

Molecular functions related to Neurilemmoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.5GFAP, DES, VIM

Products for genes affiliated with Neurilemmoma

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  • Proteins
  • Lysates
  • Antibodies

Sources for Neurilemmoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet