MCID: NRT004
MIFTS: 51

Neuritis malady

Summaries for Neuritis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may affect sensation, movement,... more...

MalaCards: Neuritis, also known as peripheral neuritis, is related to optic neuritis and multiple sclerosis. An important gene associated with Neuritis is SEPT9 (septin 9), and among its related pathways are Spinal Cord Injury and Glial Cell Differentiation. The compounds glatiramer acetate and 2,3-cyclic nucleotide have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and brain, and related mouse phenotypes are nervous system and vision/eye.

Aliases & Classifications for Neuritis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

neuritis 8 10 44 60
peripheral neuritis 8


External Ids:

Disease Ontology8 DOID:1803
MeSH34 D009443

Related Diseases for Neuritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neuritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 246)
idRelated DiseaseScoreTop Affiliating Genes
1optic neuritis31.7AQP4, PLP1, RCVRN, LTA, MAG, MPZ
2multiple sclerosis31.2MAG, MPZ, MBP, MOG, LTA, CXCL11
3neuromyelitis optica30.8AQP4, MBP, MOG
4neuropathy30.7MAG, MPZ, MBP
5encephalomyelitis30.5MOG, MBP, MPZ, LTA, PLP1, AQP4
6myelitis30.5MBP, AQP4
7encephalitis30.3TPPP3, AQP4, MBP, MOG
8acute disseminated encephalomyelitis30.3AQP4, MBP, MOG
9uveitis30.3CXCL11, RCVRN, LTA
10diabetic neuropathy30.1MPZ, SOD3
11glaucoma30.0AQP4, MBP
12tuberculosis30.0MBP
13relapsing-remitting multiple sclerosis30.0MBP, MOG
14diabetes mellitus29.9MT-ND1
15dementia29.6TPPP3, PLP1
16myasthenia gravis29.6MOG, MBP, MAG, LTA, PLP1
17tetanus29.6MOG, MBP, MPZ, LTA, PLP1
18charcot-marie-tooth disease29.6MBP, MPZ, MAG, PLP1
19transverse myelitis29.6MBP, AQP4
20polyneuropathy29.6MAG, MPZ, MBP
21brachial plexus neuropathy29.6MPZ
22neurilemmoma29.6MBP, MPZ, MAG
23adenocarcinoma29.6AQP4
24retinitis10.6
25brachial plexus neuritis10.5
26acute retrobulbar neuritis10.5
27ischemic neuropathy10.4
28ischemic optic neuropathy10.4
29hereditary neuralgic amyotrophy10.4
30systemic lupus erythematosus10.3
31herpes zoster10.3
32lupus erythematosus10.3
33leprosy10.3
34hepatitis10.2
35turner syndrome10.2
36meningitis10.2
37optic atrophy10.2
38cervicitis10.2
39parsonage turner syndrome10.2
40choroiditis10.1
41measles10.1
42influenza10.1
43optic papillitis10.1
44papilledema10.1
45scotoma10.1
46borderline leprosy10.1
47chickenpox10.1
48hepatitis a10.1
49motor neuritis10.1
50vestibular disease10.1

Graphical network of the top 20 diseases related to Neuritis:



Diseases related to neuritis

Clinical Features for Neuritis

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Drugs & Therapeutics for Neuritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Neuritis

Drug clinical trials:

Search ClinicalTrials for Neuritis

Search NIH Clinical Center for Neuritis

Search CenterWatch for Neuritis

Genetic Tests for Neuritis

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Anatomical Context for Neuritis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Neuritis:

32
T cells, Testes, Brain, Eye, Pituitary, Bone, B cells, Myeloid, Breast, Heart, Spinal cord, Liver, Lung, Pons

Animal Models for Neuritis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Neuritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.3MBP, MPZ, GHRH, MT-ND6, MAG, LTA
2MP:000539110.2AQP4, MOG, MBP, MT-ND6, LTA, RCVRN
3MP:000538710.0MOG, SOD3, MBP, MPZ, GHRH, MT-ND2

Publications for Neuritis

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Sources:
50PubMed
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Articles related to Neuritis:

(show top 50)    (show all 884)
idTitleAuthorsYear
1
Update in pediatric optic neuritis. (23872812)
2013
2
Vestibular function after vestibular neuritis. (23902522)
2013
3
An Unusual Case of Bilateral Multifocal Retinal Pigment Epithelial Detachment with Methanol-Induced Optic Neuritis. (24037809)
2013
4
Atypical cat scratch disease with vitritis, serous macular detachment, neuroretinitis, and retrobulbar optic neuritis. (22366917)
2013
5
Initiation of anti-TNF therapy and the risk of optic neuritis: from the Safety Assessment of Biologic ThERapy (SABER) Study. (23870360)
2013
6
Optic neuritis and the evaluation of visual impairment in multiple sclerosis. (23917102)
2013
7
Optic neuritis: from magnocellular to cognitive residual dysfunction. (23619084)
2013
8
Risk of multiple sclerosis after optic neuritis in patients with normal baseline brain MRI. (24231563)
2013
9
Inner nuclear layer thickening is inversley proportional to retinal ganglion cell loss in optic neuritis. (24098599)
2013
10
Multifocal visual evoked potential in optic neuritis, ischemic optic neuropathy and compressive optic neuropathy. (24088641)
2013
11
The Role of Cervical and Ocular Vestibular-Evoked Myogenic Potentials in the Follow-Up of Vestibular Neuritis. (23666957)
2013
12
Relation of video-head-impulse test and caloric irrigation: a study on the recovery in unilateral vestibular neuritis. (24096811)
2013
13
Lesional infiltration of receptor activator of nuclear factor-I_B liganda8_ cells in experimental autoimmune neuritis rats. (22810119)
2013
14
Findings of multiple neuritis on FDG PET/CT imaging. (23242055)
2013
15
Longitudinal extensive transverse myelitis and optic neuritis: the elements for the diagnosis of neuromyelitis optica. (22447361)
2013
16
MR diagnosis of facial neuritis: diagnostic performance of contrast-enhanced 3D-FLAIR technique compared with contrast-enhanced 3D-T1-fast-field echo with fat suppression. (22207300)
2012
17
Bilateral brachial neuritis secondary to varicella reactivation in an HIV-positive man. (22422694)
2012
18
Memantine for axonal loss of optic neuritis. (22173217)
2012
19
Current options for the treatment of optic neuritis. (22927730)
2012
20
Optic neuritis and retinal ganglion cell loss in a chronic murine model of multiple sclerosis. (21852980)
2011
21
Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules. (21698177)
2011
22
Proinflammatory activation of peripheral blood mononuclear cells in patients with vestibular neuritis. (20980744)
2011
23
Macrophage-mediated optic neuritis induced by retrograde axonal transport of spike gene recombinant mouse hepatitis virus. (21572336)
2011
24
Retinal nerve fiber layer thickness is associated with lesion length in acute optic neuritis. (20083802)
2010
25
Influence of retrobulbar neuritis and papillitis on echographically measured optic nerve diameter. (20225632)
2010
26
Increased immunopotency of monocyte derived dendritic cells from patients with optic neuritis is inhibited in vitro by simvastatin. (19948167)
2010
27
Patterns of retinal nerve fiber layer loss in multiple sclerosis patients with or without optic neuritis and glaucoma patients. (20452719)
2010
28
Effect of vestibular neuritis on postural control using wavelets and fractal analysis. (21866733)
2010
29
Foreign body induced neuritis masquerading as a canine brachial plexus nerve sheath tumour. (19750291)
2009
30
Optic neuritis after Klebsiella pneumonitis and liver abscess. (19491637)
2009
31
Brachial neuritis (Parsonnage-Turner syndrome) - a case study. (19211296)
2009
32
A comparison of multifocal and conventional visual evoked potential techniques in patients with optic neuritis/multiple sclerosis. (18204943)
2008
33
Effects of high-dose prednisolone on optic nerve head blood flow in patients with acute optic neuritis. (18575879)
2008
34
The etiology of optic neuritis in Asian population. (18715724)
2008
35
Retrobulbar optic neuritis and meningoencephalitis following progressive outer retinal necrosis due to CMV in a patient with AIDS. (18574556)
2008
36
MRI of optic neuritis in a rat model. (18394926)
2008
37
Treatment of corticosteroid refractory optic neuritis in multiple sclerosis patients with intravenous immunoglobulin. (18727675)
2008
38
Electrophysiological evidence for heterogeneity of lesions in optic neuritis. (17898277)
2007
39
Optic neuritis in evolution. (17719374)
2007
40
Quantitative evaluation of signal intensity of magnetic resonance images in optic neuritis. (19478862)
2007
41
Herpetic optic neuritis associated with herpetic keratitis. (17671953)
2007
42
Intravenous immunoglobulin and interferon: successful treatment of optic neuritis in pediatric multiple sclerosis. (15605474)
2004
43
Elevated expression of CCR5 by myeloid (CD11c+) blood dendritic cells in multiple sclerosis and acute optic neuritis. (11966770)
2002
44
A case of morphoea with dermal neuritis as in indeterminate leprosy. (9474518)
1997
45
Peptide specificity of anti-myelin basic protein antibodies in patients with acute optic neuritis and the HLA system. (7516573)
1994
46
Acute monocular disturbances mimicking optic neuritis in pituitary apoplexy. (3176886)
1988
47
THE TARSAL TUNNEL SYNDROME. CASE REPORT: POSTERIOR TIBIAL LEPROUS NEURITIS ASSOCIATED WITH TENDON SHEATH GANGLION. (14227401)
1964
48
Serial fundus photographs of choroiditis, optic neuritis and papilloedema. (13970196)
1962
49
Chiasmal syndrome presenting with paracentral scotoma, simulating retrobulbar neuritis. (13070042)
1953
50
Peripheral neuritis in periarteritis nodosa; a clinicopathologic study. (18115190)
1948

Genetic Variations for Neuritis

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Expression for genes affiliated with Neuritis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuritis

Search GEO for disease gene expression data for Neuritis.

Pathways for genes affiliated with Neuritis

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Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG
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Compounds for genes affiliated with Neuritis

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Neuritis according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1glatiramer acetate44 1111.8PLP1, MPZ, MBP, MOG
22,3-cyclic nucleotide4410.8PLP1, MAG, MPZ, MBP, MOG
3sulfatide4410.8MBP, MPZ, MAG, PLP1
4cerebrosides4410.8MPZ, MBP
5valine4410.7MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-ND2
6methionine4410.7SOD3, MPZ, MT-ND6, MT-ND1, MT-ND5, MT-ND2
7nadh44 11 2412.7MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-CO3, MT-ND2
8nad28 2411.7MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-ND2
9acetylcholine44 49 28 11 2414.7MOG, SOD3, MBP, MAG, LTA, PLP1
10c3bot (154-182)5910.7MOG, MBP
11ono 25065910.7MOG, MBP
12iron44 2411.7SOD3, MT-ND6, MT-ND1, MT-ND4, MT-ND2
13ivig4410.7MBP, MAG, LTA
14nogo-66 (1-40)5910.7MOG, MBP
15threonine4410.7MBP, MT-ND1, MT-ND4, MT-ND5, MT-ND2, MAG
16fatty acid4410.7PMP2, MPZ, GHRH, RCVRN, PLP1
17mog (35-55)5910.7MOG, MBP
18cysteine4410.6SOD3, MBP, MPZ, MAG, RCVRN, PLP1
19alanine4410.6SOD3, MBP, MT-ND6, MT-ND1, MT-ND5, MT-ND2
20plp (139-151)5910.6MOG, MBP
21arginine4410.6PLP1, CXCL11, GHRH, MPZ, MBP, SOD3
22serine4410.6MOG, SOD3, MBP, MPZ, GHRH, MT-ND6
23lipid4410.6MBP, SOD3, MOG, PMP2, MPZ, GHRH
24ganglioside4410.6MBP, MPZ, MAG
25glutamate4410.5MBP, MPZ, GHRH, LTA, PLP1, AQP4
26silver4410.5PLP1, MBP, MOG
27glucose4410.5MOG, GHRH
28urea44 11 2412.4AQP4, GHRH, SOD3
29phospholipid4410.4PLP1, RCVRN, GHRH, MBP
30cholesterol44 28 11 2413.3SOD3, MPZ, GHRH, LTA, PLP1
31oligonucleotide4410.1MT-ND5, LTA, CXCL11, PLP1, AQP4

GO Terms for genes affiliated with Neuritis

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16Gene Ontology
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Cellular components related to Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:04320910.5PLP1, MPZ

Biological processes related to Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of axonogenesisGO:05077110.4MAG, MBP
2axon ensheathmentGO:00836610.3PLP1, MBP
3membrane organizationGO:06102410.1MBP, PMP2

Molecular functions related to Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of myelin sheathGO:01991110.4PLP1, MBP

Products for genes affiliated with Neuritis

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  • Antibodies
  • Proteins
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Sources for Neuritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet