MCID: NRT004
MIFTS: 51

Neuritis malady

Summaries for Neuritis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Peripheral neuropathy (PN) is damage or disease affecting nerves, which may affect sensation, movement,... more...

MalaCards: Neuritis, also known as peripheral neuritis, is related to optic neuritis and multiple sclerosis. An important gene associated with Neuritis is SEPT9 (septin 9), and among its related pathways are Spinal Cord Injury and Glial Cell Differentiation. The compounds glatiramer acetate and 2,3-cyclic nucleotide have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and brain, and related mouse phenotypes are nervous system and vision/eye.

Aliases & Classifications for Neuritis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

neuritis 8 10 44 60
peripheral neuritis 8


External Ids:

Disease Ontology8 DOID:1803
MeSH34 D009443

Related Diseases for Neuritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neuritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 246)
idRelated DiseaseScoreTop Affiliating Genes
1optic neuritis31.7AQP4, PLP1, RCVRN, LTA, MAG, MPZ
2multiple sclerosis31.2MAG, MPZ, MBP, MOG, LTA, CXCL11
3neuromyelitis optica30.8AQP4, MBP, MOG
4neuropathy30.7MAG, MPZ, MBP
5encephalomyelitis30.5MOG, MBP, MPZ, LTA, PLP1, AQP4
6myelitis30.5MBP, AQP4
7encephalitis30.3TPPP3, AQP4, MBP, MOG
8acute disseminated encephalomyelitis30.3AQP4, MBP, MOG
9uveitis30.3CXCL11, RCVRN, LTA
10diabetic neuropathy30.1MPZ, SOD3
11glaucoma30.0AQP4, MBP
12tuberculosis30.0MBP
13relapsing-remitting multiple sclerosis30.0MBP, MOG
14diabetes mellitus29.9MT-ND1
15dementia29.6TPPP3, PLP1
16myasthenia gravis29.6MOG, MBP, MAG, LTA, PLP1
17tetanus29.6MOG, MBP, MPZ, LTA, PLP1
18charcot-marie-tooth disease29.6MBP, MPZ, MAG, PLP1
19transverse myelitis29.6MBP, AQP4
20polyneuropathy29.6MAG, MPZ, MBP
21brachial plexus neuropathy29.6MPZ
22neurilemmoma29.6MBP, MPZ, MAG
23adenocarcinoma29.6AQP4
24retinitis10.6
25brachial plexus neuritis10.5
26acute retrobulbar neuritis10.5
27ischemic neuropathy10.4
28ischemic optic neuropathy10.4
29hereditary neuralgic amyotrophy10.4
30systemic lupus erythematosus10.3
31herpes zoster10.3
32lupus erythematosus10.3
33leprosy10.3
34hepatitis10.2
35turner syndrome10.2
36meningitis10.2
37optic atrophy10.2
38cervicitis10.2
39parsonage turner syndrome10.2
40choroiditis10.1
41measles10.1
42influenza10.1
43optic papillitis10.1
44papilledema10.1
45scotoma10.1
46borderline leprosy10.1
47chickenpox10.1
48hepatitis a10.1
49motor neuritis10.1
50vestibular disease10.1

Graphical network of the top 20 diseases related to Neuritis:



Diseases related to neuritis

Clinical Features for Neuritis

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Drugs & Therapeutics for Neuritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Neuritis

Drug clinical trials:

Search ClinicalTrials for Neuritis

Search NIH Clinical Center for Neuritis

Search CenterWatch for Neuritis

Genetic Tests for Neuritis

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Anatomical Context for Neuritis

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Sources:
32MalaCards
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MalaCards organs/tissues related to Neuritis:

32
T cells, Testes, Brain, Eye, Pituitary, Bone, Liver, Heart, Spinal cord, Myeloid, B cells, Breast, Lung, Pons

Animal Models for Neuritis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Neuritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363110.3MBP, MPZ, GHRH, MT-ND6, MAG, LTA
2MP:000539110.2AQP4, MOG, MBP, MT-ND6, LTA, RCVRN
3MP:000538710.0MOG, SOD3, MBP, MPZ, GHRH, MT-ND2

Publications for Neuritis

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Sources:
50PubMed
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Articles related to Neuritis:

(show top 50)    (show all 884)
idTitleAuthorsYear
1
Intravenous immunoglobulin preparation attenuates neurological signs in rat experimental autoimmune neuritis with the suppression of macrophage inflammatory protein -1I+ expression. (24262701)
2014
2
Acute disseminated encephalomyelitis without optic neuritis followed by optic neuritis in a child due to the sudden cessation of steroid therapy. (24171829)
2014
3
Chrysin Attenuates Experimental Autoimmune Neuritis by Suppressing Immuno-inflammatory Responses. (24412705)
2014
4
Benign paroxysmal positional vertigo secondary to vestibular neuritis. (23575935)
2013
5
Acute disseminated encephalomyelitis followed by recurrent or monophasic optic neuritis in pediatric patients. (23128668)
2013
6
Calpain inhibitor attenuated optic nerve damage in acute optic neuritis in rats. (23106593)
2013
7
Aquaporin-4 antibody negative recurrent isolated optic neuritis: clinical evidence for disease heterogeneity. (23735776)
2013
8
Vertical eye movements during horizontal head impulse test: a new clinical sign of superior vestibular neuritis. (24376299)
2013
9
Brachial plexus neuritis in the context of acute HIV seroconversion illness: a case report. (22422693)
2012
10
Pioglitazone, PPARI^ agonist, attenuates experimental autoimmune neuritis. (22389055)
2012
11
The strategies used for treatment of experimental autoimmune neuritis (EAN): a beneficial effect of glatiramer acetate administered intraperitoneally. (21234710)
2012
12
Optic neuritis: a blurry issue. (23135019)
2012
13
Role of NMO-IgG in distinguishing the type of optic neuritis. (22105332)
2012
14
Clinical characteristics of optic neuritis in Koreans greater than 50 years of age. (22511837)
2012
15
Quantification of retinal neural loss in patients with neuromyelitis optica and multiple sclerosis with or without optic neuritis using Fourier-domain optical coherence tomography. (22589446)
2012
16
Effector and regulatory T cells in patients with acute optic neuritis. (22248727)
2012
17
Unilateral optic neuritis, scleritis and exudative retinal detachment due to recurrent orbital pseudotumor. (23961032)
2012
18
Brachial neuritis masquerading as acute coronary syndrome. (20838916)
2011
19
Childhood optic neuritis clinical features and outcome. (20554767)
2011
20
Early factors associated with axonal loss after optic neuritis. (22190367)
2011
21
Neuromyelitis optica-IgG+ optic neuritis associated with celiac disease and dysgammaglobulinemia: a role for tacrolimus? (20937563)
2011
22
Optical coherence tomography in the diagnosis and management of optic neuritis and multiple sclerosis. (21790109)
2011
23
Clinical characteristics, therapeutic outcomes of isolated atypical optic neuritis in China. (21470641)
2011
24
Unilateral optic neuritis as a presentation of neurobrucellosis. (21772948)
2011
25
Early observations on optic neuritis and Uhthoff's sign. (20375511)
2010
26
A tiny infarct on the dorsolateral pons mimicking vestibular neuritis. (20737436)
2010
27
Prevalence of systemic lupus erythematosus-associated optic neuritis. (19832731)
2010
28
Measurement of retinal nerve fiber layer thickness in optic atrophy eyes of patients with optic neuritis using optical coherence tomography. (20191363)
2010
29
Vestibular neuritis. (19834862)
2009
30
Epstein-Barr virus-related optic neuritis as a precursor to the development of posttransplant lymphoproliferative disease. (19252447)
2009
31
Visual function 15 years after optic neuritis: a final follow-up report from the Optic Neuritis Treatment Trial. (17976727)
2008
32
Optic neuritis due to solvent abuse. (18392432)
2008
33
Correlation between full-field and multifocal VEPs in optic neuritis. (17680288)
2008
34
Unilateral optic neuritis as the presenting symptom of human immunodeficiency virus toxoplasmosis infection. (17986296)
2008
35
Optic neuritis as the first manifestation of rheumatoid arthritis. (18769294)
2008
36
The relationship between HLA-DRB1 alleles and optic neuritis in Irish patients and the risk of developing multiple sclerosis. (17895416)
2007
37
Inflammation and proinflammatory cytokine production, but no demyelination of facial nerves, in experimental autoimmune neuritis in Lewis rats. (12864976)
2003
38
Primary SjAPgren's syndrome initially manifested by optic neuritis: MRI findings. (11914812)
2002
39
The expression of CD59 in experimental allergic neuritis. (10450801)
1999
40
Antigen therapy eliminates T cell inflammation by apoptosis: effective treatment of experimental autoimmune neuritis with recombinant myelin protein P2. (9037054)
1997
41
Bilateral brachial plexus neuritis following parvovirus B19 and cytomegalovirus infection. (9007101)
1996
42
Optic neuritis and multiple sclerosis: anti-MBP and anti-MBP peptide antibody-secreting cells are accumulated in CSF. (7513391)
1993
43
Eosinophilic neuritis, perimyositis, and vasculitis associated with ingestion of L-tryptophan. (2388201)
1990
44
Optic neuritis and Jaccoud's syndrome in a patient with systemic lupus erythematosus. (6658401)
1983
45
Hereditary syndrome consisting in recurrent attacks resembling brachial plexus neuritis, special facial features, and cleft palate. (4428970)
1974
46
A case of hypertrophic interstitial neuritis coexisting with dementia and cerebellar degeneration. (5319475)
1965
47
GAS GANGRENE INFECTION, ANTITOXIN, AND SERUM NEURITIS. (14331998)
1965
48
Epidemiologic study of a brachial plexus neuritis outbreak in northeast Czechoslovakia. (13864958)
1961
49
ACUTE RETROBULBAR NEURITIS AFFECTING THE OPTIC CHIASMA AND TRACT. (18168493)
1925
50
Acute Retrobulbar Neuritis of Septic Origin, Resulting in Rapid and Complete Loss of Vision. (16692461)
1918

Genetic Variations for Neuritis

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Expression for genes affiliated with Neuritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuritis

Search GEO for disease gene expression data for Neuritis.

Pathways for genes affiliated with Neuritis

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Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG
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Compounds for genes affiliated with Neuritis

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Neuritis according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1glatiramer acetate44 1111.8PLP1, MPZ, MBP, MOG
22,3-cyclic nucleotide4410.8PLP1, MAG, MPZ, MBP, MOG
3sulfatide4410.8MBP, MPZ, MAG, PLP1
4cerebrosides4410.8MPZ, MBP
5valine4410.7MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-ND2
6methionine4410.7SOD3, MPZ, MT-ND6, MT-ND1, MT-ND5, MT-ND2
7nadh44 11 2412.7MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-CO3, MT-ND2
8nad28 2411.7MT-ND6, MT-ND1, MT-ND4, MT-ND5, MT-ND2
9acetylcholine44 49 28 11 2414.7MOG, SOD3, MBP, MAG, LTA, PLP1
10c3bot (154-182)5910.7MOG, MBP
11ono 25065910.7MOG, MBP
12iron44 2411.7SOD3, MT-ND6, MT-ND1, MT-ND4, MT-ND2
13ivig4410.7MBP, MAG, LTA
14nogo-66 (1-40)5910.7MOG, MBP
15threonine4410.7MBP, MT-ND1, MT-ND4, MT-ND5, MT-ND2, MAG
16fatty acid4410.7PMP2, MPZ, GHRH, RCVRN, PLP1
17mog (35-55)5910.7MOG, MBP
18cysteine4410.6SOD3, MBP, MPZ, MAG, RCVRN, PLP1
19alanine4410.6SOD3, MBP, MT-ND6, MT-ND1, MT-ND5, MT-ND2
20plp (139-151)5910.6MOG, MBP
21arginine4410.6PLP1, CXCL11, GHRH, MPZ, MBP, SOD3
22serine4410.6MOG, SOD3, MBP, MPZ, GHRH, MT-ND6
23lipid4410.6MBP, SOD3, MOG, PMP2, MPZ, GHRH
24ganglioside4410.6MBP, MPZ, MAG
25glutamate4410.5MBP, MPZ, GHRH, LTA, PLP1, AQP4
26silver4410.5PLP1, MBP, MOG
27glucose4410.5MOG, GHRH
28urea44 11 2412.4AQP4, GHRH, SOD3
29phospholipid4410.4PLP1, RCVRN, GHRH, MBP
30cholesterol44 28 11 2413.3SOD3, MPZ, GHRH, LTA, PLP1
31oligonucleotide4410.1MT-ND5, LTA, CXCL11, PLP1, AQP4

GO Terms for genes affiliated with Neuritis

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16Gene Ontology
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Cellular components related to Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:04320910.5PLP1, MPZ

Biological processes related to Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of axonogenesisGO:05077110.4MAG, MBP
2axon ensheathmentGO:00836610.3PLP1, MBP
3membrane organizationGO:06102410.1MBP, PMP2

Molecular functions related to Neuritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of myelin sheathGO:01991110.4PLP1, MBP

Products for genes affiliated with Neuritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neuritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet