NB
MCID: NRB001
MIFTS: 71

Neuroblastoma (NB) malady

Neuronal diseases, Cancer diseases categories

Summaries for Neuroblastoma

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Sources:
21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  it occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  it is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).  the symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  it affects one out of 100,000 children.  the exact cause of this tumor is not yet known.  neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (mri), or computed tomography (ct) scans; and a biopsy.  treatment depends on the size and location of the tumor within the body, as well as the child’s age. surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases. last updated: 10/7/2011

MalaCards: Neuroblastoma, also known as neural crest tumor, is related to adrenal neuroblastoma and lung cancer, and has symptoms including central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer, organic acid metabolism anomalies and autosomal dominant inheritance. An important gene associated with Neuroblastoma is NME1 (NME/NM23 nucleoside diphosphate kinase 1). The compounds paraffin and doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, bone and testes.

Genetics Home Reference:21 Neuroblastoma is a type of cancer that most often affects children. Neuroblastoma occurs when immature nerve cells called neuroblasts become abnormal and multiply uncontrollably to form a tumor. Most commonly, the tumor originates in the nerve tissue of the adrenal gland located above each kidney. Other common sites for tumors to form include the nerve tissue in the abdomen, chest, neck, or pelvis. Neuroblastoma can spread (metastasize) to other parts of the body such as the bones, liver, or skin.

MedlinePlus:33 Neuroblastoma is a cancer that forms in your nerve tissue. it usually begins in the adrenal glands, which sit atop your kidneys. it may also begin in your neck, chest or spinal cord. the cancer often begins in early childhood. sometimes it begins before a child is born. by the time doctors find the cancer, it has usually spread to other parts of the body. the most common symptoms are a lump in the abdomen, neck or chest bulging eyes dark circles around the eyes bone pain swollen stomach and trouble breathing in babies painless, bluish lumps under the skin in babies inability to move a body part treatments include surgery, radiation therapy, chemotherapy, biologic therapy, or a combination. biologic therapy boosts your body's own ability to fight cancer. sometimes before giving treatment, doctors wait to see whether symptoms get worse. this is called watchful waiting. nih: national cancer institute

Wikipedia:63 Neuroblastoma (NB) is the most common extracranial solid cancer in childhood and the most common cancer... more...

Description from OMIM:46 256700, 613013, 613014, 613015, 613016 613017 more

Aliases & Classifications for Neuroblastoma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 48Orphanet, 33MedlinePlus, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
neuroblastoma:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Childhood; Age of death: Child / adolescent


Aliases & Descriptions:

neuroblastoma 8 9 42 22 21 46 10 48 33
neural crest tumor 48 60
sympathicoblastoma 8 60
nb 42 21
central neuroblastoma 60
neuroblastoma nos 8
sympathoblastoma 48


External Ids:

Disease Ontology8 DOID:769
NCIt39 C3270
MeSH34 D009447
MESH via Orphanet35 C536408, D009447
ICD10 via Orphanet26 C47
SNOMED-CT via Orphanet57 432328008, 87364003
UMLS via Orphanet61 C0027819, C2931189

Related Diseases for Neuroblastoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Neuroblastoma:



Diseases related to neuroblastoma

Clinical Features for Neuroblastoma

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

256700,613013,613014,613015,613016,613017

Symptoms:

48
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • organic acid metabolism anomalies
  • autosomal dominant inheritance

Drugs & Therapeutics for Neuroblastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Neuroblastoma

Drug clinical trials:

Search ClinicalTrials for Neuroblastoma

Search NIH Clinical Center for Neuroblastoma

Search CenterWatch for Neuroblastoma

Genetic Tests for Neuroblastoma

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22GTR
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Genetic tests related to Neuroblastoma:

id Genetic test Affiliating Genes
1 Neuroblastoma22

Anatomical Context for Neuroblastoma

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32MalaCards
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MalaCards organs/tissues related to Neuroblastoma:

32
Adrenal gland, Bone, Testes, Eye, Kidney, Skin, Liver, Bone marrow, Brain, Spinal cord, Endothelial, Pituitary, Lung, T cells, Thyroid, Monocytes, Nk cells, Lymph node, Breast, Prostate, Colon, Cerebellum, Fetal brain, Smooth muscle, Ovary, Salivary gland, Placenta, Pancreas, Dorsal root ganglion, B cells, Myeloid, Testis, Parietal lobe, Skeletal muscle, Heart

Animal Models for Neuroblastoma or affiliated genes

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Publications for Neuroblastoma

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50PubMed
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Articles related to Neuroblastoma:

(show top 50)    (show all 4239)
idTitleAuthorsYear
1
JNK Is Necessary for Oligodendrocyte Precursor Cell Proliferation Induced by the Conditioned Medium from B104 Neuroblastoma Cells. (24122238)
2013
2
Neuroblastoma and tooth abnormalities: a common history? (23352669)
2013
3
Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma. (23792191)
2013
4
Interplay between cholesterol and homocysteine in the exacerbation of amyloid-I^ toxicity in human neuroblastoma cells. (23844691)
2013
5
Troglitazone, a thiazolidinedione, decreases tau phosphorylation through the inhibition of cyclin-dependent kinase 5 activity in SH-SY5Y neuroblastoma cells and primary neurons. (23581463)
2013
6
In vitro neuroprotective potential of four medicinal plants against rotenone-induced toxicity in SH-SY5Y neuroblastoma cells. (24330357)
2013
7
Targeting gastrin-releasing peptide suppresses neuroblastoma progression via upregulation of PTEN signaling. (24039782)
2013
8
Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. (22350409)
2012
9
Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma. (20096688)
2010
10
The neuroprotective role of tissue inhibitor of metalloproteinase-2 in MPP+- or 6-OHDA-treated SK-N-BE(2)C and SH-SY5Y human neuroblastoma cells. (19883732)
2010
11
Disease stabilization of progressive olfactory neuroblastoma (esthesioneuroblastoma) under treatment with sunitinib mesylate. (19820899)
2010
12
Human neuroblastoma cells with MYCN amplification are selectively resistant to oxidative stress by transcriptionally up-regulating glutamate cysteine ligase. (20180881)
2010
13
Genistein induces receptor and mitochondrial pathways and increases apoptosis during BCL-2 knockdown in human malignant neuroblastoma SK-N-DZ cells. (19813266)
2010
14
NFkappaB signaling related molecular alterations in human neuroblastoma cells after fractionated irradiation. (19436149)
2009
15
RET protein promotes non-adherent growth of NB-39-nu neuroblastoma cell line. (19320641)
2009
16
The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells. (19735367)
2009
17
Nonplatinum-based chemotherapy with irinotecan plus docetaxel for advanced or metastatic olfactory neuroblastoma: a retrospective analysis of 12 cases. (18189294)
2008
18
Correlation of modified Shimada classification with MYCN and 1p36 status detected by fluorescence in situ hybridization in neuroblastoma. (17213019)
2007
19
5 '-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway. (17065104)
2006
20
Cytopathologic features of olfactory neuroblastoma. (16456848)
2006
21
Olfactory neuroblastoma: the 22-year experience at one comprehensive cancer center. (15654688)
2005
22
Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma. (15949893)
2005
23
Germline PHOX2B mutation in hereditary neuroblastoma. (15338462)
2004
24
In vivo treatment with CPT-11 leads to differentiation of neuroblastoma xenografts and topoisomerase I alterations. (15126363)
2004
25
The Notch signaling cascade in neuroblastoma: role of the basic helix-loop-helix proteins HASH-1 and HES-1. (15013216)
2004
26
Full-length expanded ataxin-3 enhances mitochondrial-mediated cell death and decreases Bcl-2 expression in human neuroblastoma cells. (15504352)
2004
27
Apoptosis induced by beta-amyloid25-35 in acetylcholinesterase-overexpressing neuroblastoma cells. (12956931)
2003
28
cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells. (12626434)
2003
29
MYCN enhances P-gp/MDR1 gene expression in the human metastatic neuroblastoma IGR-N-91 model. (12819037)
2003
30
Study on pathological features and diagnosis, differential diagnosis of olfactory neuroblastoma]. (14633455)
2003
31
Interaction of Arc with CaM kinase II and stimulation of neurite extension by Arc in neuroblastoma cells expressing CaM kinase II. (14630344)
2003
32
GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma. (12234979)
2002
33
Infrequent mutations of the activating transcription factor-2 gene in human lung cancer, neuroblastoma and breast cancer. (11836564)
2002
34
Angiogenesis and neuroblastomas: interleukin-8 and interleukin-8 receptor expression in human neuroblastoma. (10958731)
2000
35
Retinoic acid modulates stem cell factor secretion by human neuroblastoma cell lines. (11205272)
2000
36
Specific fiber deficits in sensorimotor diabetic polyneuropathy correspond to cytotoxicity against neuroblastoma cells of sera from patients with diabetes. (10546017)
1999
37
Smooth muscle myosin of SM1 and SM2 isoforms expressing human neuroblastoma cell line of MP-N-MS]. (10457905)
1999
38
The role of cellular motility in the invasion of human neuroblastoma cells with or without N-myc amplification and expression. (9869047)
1998
39
EWS-FLI1 fusion transcripts identified in patients with typical neuroblastoma. (9135495)
1997
40
Recognition of central nervous system metastases in children with metastatic primary extracranial neuroblastoma. (9185208)
1997
41
Lack of class I HLA expression in neuroblastoma is associated with high N-myc expression and hypomethylation due to loss of the MEMO-1 locus. (8895520)
1996
42
Low potency inhibition of Ca2+ channel currents in human neuroblastoma (SH-SY5Y) cells by [Ala31]NPY, an L-alanine substituted analogue of neuropeptide Y. (7637888)
1995
43
Equivalent regulation of wild type and an epitope-tagged variant of Gs alpha by the IP prostanoid receptor following expression in neuroblastoma x glioma hybrid, NG108-15, cells. (7525345)
1994
44
Prenatal diagnosis of cerebral neuroblastoma by fetal brain biopsy. (8345560)
1993
45
Stimulation of phospholipase D activity in human neuroblastoma (LA-N-2) cells by activation of muscarinic acetylcholine receptors or by phorbol esters: relationship to phosphoinositide turnover. (2002344)
1991
46
Protein kinase C and its 80-kilodalton substrate protein in neuroblastoma cell neurite outgrowth. (2293618)
1990
47
Gene amplification in human neuroblastomas: basic mechanisms and clinical implications. (3940169)
1986
48
The chemical diagnosis of ganglioneuroma and neuroblastoma using random specimens of urine. (4354246)
1970
49
Olfactory neuroblastoma; an uncommon nasal tumour. (6058522)
1967
50
On adrenal neuroblastoma; report of four cases. (14829999)
1951

Genetic Variations for Neuroblastoma

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Expression for genes affiliated with Neuroblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroblastoma

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Pathways for genes affiliated with Neuroblastoma

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Compounds for genes affiliated with Neuroblastoma

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Neuroblastoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1paraffin4411.6TP73, ALK, NME1, MYCN, TOP2A
2doxorubicin44 49 1113.2TOP2A, MYCN, ALK, TP73
3vincristine44 49 1113.1TOP2A, MYCN, TP73
4adriamycin4411.1TP73, MYCN, TOP2A
5p0024410.8TP73, NME1, TOP2A

GO Terms for genes affiliated with Neuroblastoma

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16Gene Ontology
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Cellular components related to Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573712.8NBPF8, LIN28B, NME1, NBAS, NBPF15, NBPF3

Molecular functions related to Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II regulatory region sequence-specific DNA bindingGO:00097710.9NME1, PHOX2B

Products for genes affiliated with Neuroblastoma

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Sources for Neuroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet