NB
MCID: NRB001
MIFTS: 70

Neuroblastoma (NB) malady

Genetic diseases, Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Neuroblastoma

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Sources:
44NIH Rare Diseases, 35MedlinePlus, 22Genetics Home Reference, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  it occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  it is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).  the symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  it affects one out of 100,000 children.  the exact cause of this tumor is not yet known.  neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (mri), or computed tomography (ct) scans; and a biopsy.  treatment depends on the size and location of the tumor within the body, as well as the child’s age. surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases. last updated: 10/7/2011

MalaCards: Neuroblastoma, also known as neural crest tumor, is related to adrenal neuroblastoma and leukemia, and has symptoms including central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer, organic acid metabolism anomalies and autosomal dominant inheritance. An important gene associated with Neuroblastoma is NME1 (NME/NM23 nucleoside diphosphate kinase 1). The compounds paraffin and doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, bone and testes.

MedlinePlus:35 Neuroblastoma is a cancer that forms in your nerve tissue. it usually begins in the adrenal glands, which sit atop your kidneys. it may also begin in your neck, chest or spinal cord. the cancer often begins in early childhood. sometimes it begins before a child is born. by the time doctors find the cancer, it has usually spread to other parts of the body. the most common symptoms are a lump in the abdomen, neck or chest bulging eyes dark circles around the eyes bone pain swollen stomach and trouble breathing in babies painless, bluish lumps under the skin in babies inability to move a body part treatments include surgery, radiation therapy, chemotherapy, biologic therapy, or a combination. biologic therapy boosts your body's own ability to fight cancer. sometimes before giving treatment, doctors wait to see whether symptoms get worse. this is called watchful waiting. nih: national cancer institute

Genetics Home Reference:22 Neuroblastoma is a type of cancer that most often affects children. Neuroblastoma occurs when immature nerve cells called neuroblasts become abnormal and multiply uncontrollably to form a tumor. Most commonly, the tumor originates in the nerve tissue of the adrenal gland located above each kidney. Other common sites for tumors to form include the nerve tissue in the abdomen, chest, neck, or pelvis. Neuroblastoma can spread (metastasize) to other parts of the body such as the bones, liver, or skin.

Wikipedia:66 Neuroblastoma (NB) is the most common extracranial solid cancer in childhood and the most common cancer... more...

Description from OMIM:48 256700, 613013, 613014, 613015, 613016 613017 more

Aliases & Classifications for Neuroblastoma

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Sources:
9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 23GTR, 22Genetics Home Reference, 48OMIM, 11DISEASES, 50Orphanet, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

50
neuroblastoma:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Childhood; Age of death: Child / adolescent


Aliases & Descriptions:

neuroblastoma 9 10 44 23 22 48 11 50 35
neural crest tumor 50 63
sympathicoblastoma 9 63
nb 44 22
central neuroblastoma 63
neuroblastoma nos 9
sympathoblastoma 50


External Ids:

Disease Ontology9 DOID:769
NCIt41 C3270
MeSH36 D009447
MESH via Orphanet37 C536408, D009447
ICD10 via Orphanet27 C47
SNOMED-CT via Orphanet60 432328008, 87364003
UMLS via Orphanet64 C0027819, C2931189

Related Diseases for Neuroblastoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Neuroblastoma family:

Neuroblastoma 1 Neuroblastoma 6
Neuroblastoma 3 Neuroblastoma 5
Neuroblastoma 2 Neuroblastoma 4

Diseases related to Neuroblastoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 303)
idRelated DiseaseScoreTop Affiliating Genes
1adrenal neuroblastoma31.4MYCN, PHOX2B
2leukemia30.7NME1, ALK, TOP2A, MYCN, TP73
3retinoblastoma30.6NME1, TOP2A, MYCN, TP73
4lung cancer30.4TP73, MYCN, TOP2A, ALK, NME1
5wilms tumor30.4TP73, MYCN, TOP2A
6embryonal rhabdomyosarcoma30.3ALK, MYCN
7meningioma30.0TP73, TOP2A
8breast cancer30.0NME1, TOP2A, MYCN, TP73
9burkitt's lymphoma29.9TP73, ALK
10glioblastoma multiforme29.8ALK, TOP2A, MYCN, TP73
11neurofibroma29.8TP73, TOP2A
12non-hodgkin lymphoma29.7MYCN, TOP2A, ALK
13ovarian cancer29.7TP73, MYCN, TOP2A, NME1
14olfactory neuroblastoma11.0
15neuronitis10.8
16differentiating neuroblastoma10.7
17cerebral neuroblastoma10.7
18cerebritis10.6
19ganglioneuroma10.6
20hypoxia10.6
21ganglioneuroblastoma10.6
22nijmegen breakage syndrome10.6
23prostate adenocarcinoma10.5
24endotheliitis10.5
25pheochromocytoma10.4
26sarcoma10.4
27nephroblastoma10.4
28astrocytoma10.4
29rhabdomyosarcoma10.4
30neuroepithelioma10.4
31neuroblastoma 110.4
32myoclonus10.3
33hiv-110.3
34vitiligo10.3
35melanoma10.3
36phaeochromocytoma10.3
37primitive neuroectodermal tumor10.3
38alzheimer's disease10.3
39neuropathy10.3
40thyroiditis10.3
41cervicitis10.2
42diarrhea10.2
43obesity10.2
44hepatitis10.2
45pertussis10.2
46teratoma10.2
47neurofibromatosis10.2
48extracranial neuroblastoma10.2
49beckwith-wiedemann syndrome10.2
50paraganglioma10.2

Graphical network of the top 20 diseases related to Neuroblastoma:



Diseases related to neuroblastoma

Symptoms for Neuroblastoma

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48OMIM, 50Orphanet
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Clinical features from OMIM:

256700,613013,613014,613015,613016,613017

Symptoms:

50
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • organic acid metabolism anomalies
  • autosomal dominant inheritance

Drugs & Therapeutics for Neuroblastoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Neuroblastoma

Drug clinical trials:

Search ClinicalTrials for Neuroblastoma

Search NIH Clinical Center for Neuroblastoma

Search CenterWatch for Neuroblastoma

Genetic Tests for Neuroblastoma

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Sources:
23GTR
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Genetic tests related to Neuroblastoma:

id Genetic test Affiliating Genes
1 Neuroblastoma23

Anatomical Context for Neuroblastoma

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Sources:
34MalaCards
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MalaCards organs/tissues related to Neuroblastoma:

34
Adrenal gland, Bone, Testes, Eye, Bone marrow, Brain, Kidney, Spinal cord, Skin, Endothelial, Liver, Pituitary, Lung, T cells, Thyroid, Lymph node, Nk cells, Monocytes, Breast, Prostate, Colon, Cerebellum, Ovary, Fetal brain, Smooth muscle, Dorsal root ganglion, Salivary gland, Testis, Pancreas, B cells, Myeloid, Placenta, Parietal lobe, Skeletal muscle, Heart

Animal Models for Neuroblastoma or affiliated genes

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Publications for Neuroblastoma

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Sources:
53PubMed
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Articles related to Neuroblastoma:

(show top 50)    (show all 4191)
idTitleAuthorsYear
1
The mechanism of alternative splicing of the X-linked NDUFB11 gene of the respiratory chain complex I, impact of rotenone treatment in neuroblastoma cells. (23246602)
2013
2
In vitro approaches to evaluate toxicity induced by organotin compounds tributyltin (TBT), dibutyltin (DBT), and monobutyltin (MBT) in neuroblastoma cells. (23534342)
2013
3
Copper(II) mixed chelate compounds induce apoptosis through reactive oxygen species in neuroblastoma cell line CHP-212. (23727332)
2013
4
Neuroblastoma in Iran: an experience of 32 years at a referral childrens hospital. (23803024)
2013
5
Akt2 regulates metastatic potential in neuroblastoma. (23468863)
2013
6
Estradiol and testosterone regulate arginine-vasopressin expression in SH-SY5Y human female neuroblastoma cells through estrogen receptors-I+ and -I^. (23584859)
2013
7
Reply: Comment on 'Quiescence and yH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase': ouabain and cancer. (23681184)
2013
8
Adenovirus arming human IL-24 inhibits neuroblastoma cell proliferation in vitro and xenograft tumor growth in vivo. (23609032)
2013
9
The protective effect of geniposide on human neuroblastoma cells in the presence of formaldehyde. (23815892)
2013
10
Novel synthetic monoketone transmute radiation-triggered NFI_B-dependent TNFI+ cross-signaling feedback maintained NFI_B and favors neuroblastoma regression. (23967300)
2013
11
Distinct neuroblastoma-associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish models. (23754957)
2013
12
Oncogenic mutations of ALK in neuroblastoma. (21205076)
2011
13
Neuroblastoma cell proliferation is sensitive to changes in levels of RUNX1 and RUNX3 protein. (21640801)
2011
14
2p24 Gain region harboring MYCN gene compared with MYCN amplified and nonamplified neuroblastoma: biological and clinical characteristics. (20395439)
2010
15
Genes involved in regulation of stem cell properties: studies on their expression in a small cohort of neuroblastoma patients. (19458492)
2009
16
The cytologic features of sinonasal undifferentiated carcinoma and olfactory neuroblastoma. (18285258)
2008
17
Small-interfering-RNA-mediated silencing of human glutamate dehydrogenase induces apoptosis in neuroblastoma cells. (18248328)
2008
18
Prospective tracing of MLL-FRYL clone with low MEIS1 expression from emergence during neuroblastoma treatment to diagnosis of myelodysplastic syndrome. (18195096)
2008
19
Selenium protects the hypoxia induced apoptosis in neuroblastoma cells through upregulation of Bcl-2. (18405886)
2008
20
Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor. (16790237)
2006
21
Halting neuroblastoma metastasis by controlling integrin-mediated death. (16582638)
2006
22
No evidence for involvement of SDHD in neuroblastoma pathogenesis. (15331017)
2004
23
Germline PHOX2B mutation in hereditary neuroblastoma. (15338462)
2004
24
Basic helix-loop-helix proteins bind to TrkB and p21(Cip1) promoters linking differentiation and cell cycle arrest in neuroblastoma cells. (15024057)
2004
25
Methylation-associated silencing of the thrombospondin-1 gene in human neuroblastoma. (14559817)
2003
26
Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma. (12888911)
2003
27
5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells. (12654334)
2003
28
GADD153 and 12-lipoxygenase mediate fenretinide-induced apoptosis of neuroblastoma. (12234979)
2002
29
Synergistic effect of retinoic acid and dehydroepiandrosterone on differentiation of human neuroblastoma cells. (12459481)
2002
30
Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line. (11812636)
2002
31
MycN sensitizes neuroblastoma cells for drug-triggered apoptosis. (11107122)
2000
32
Posterior mediastinal capillary hemangioma with extradural extension resembling neuroblastoma. (10398787)
1999
33
Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells. (9647654)
1998
34
Different voltage-gated sodium currents are expressed by human neuroblastoma NB69 cells when cultured in defined serum-free and in astroglial-conditioned media. (9034832)
1997
35
Expression of CD44 isoforms in neuroblastoma cells is regulated by PI 3-kinase and protein kinase C. (9190898)
1997
36
Identification and characterization of a retinoic acid-regulated human homologue of the unc-33-like phosphoprotein gene (hUlip) from neuroblastoma cells. (9115293)
1997
37
Determinants of the stimulatory opioid effect on intracellular calcium in SK-N-SH and NG108-15 neuroblastoma. (8813369)
1996
38
Regulation of corticotropin-releasing factor secretion and synthesis in the human neuroblastoma clones- BE(2)-M17 and BE(2)-C. (7550293)
1995
39
Possible involvement of the 440 kDa isoform of ankyrinB in neuritogenesis in human neuroblastoma NB-1 cells. (7805894)
1995
40
Expression of stem cell factor and c-kit in human neuroblastoma. The Children's Cancer Group. (7524740)
1994
41
Equivalent regulation of wild type and an epitope-tagged variant of Gs alpha by the IP prostanoid receptor following expression in neuroblastoma x glioma hybrid, NG108-15, cells. (7525345)
1994
42
Olfactory neuroblastoma. (1497735)
1992
43
Carbachol enhances forskolin-stimulated cyclic AMP accumulation via activation of calmodulin system in human neuroblastoma SH-SY5Y cells. (1712584)
1991
44
Reversible effects of sphingomyelin degradation on cholesterol distribution and metabolism in fibroblasts and transformed neuroblastoma cells. (2222406)
1990
45
Olfactory neuroblastoma: report of a case and review of the literature. (2651629)
1989
46
Olfactory neuroblastoma: presentation of a case and review of the Japanese literature. (6694503)
1984
47
Surgical pathology of olfactory neuroblastoma. (6490385)
1984
48
Pigmented olfactory neuroblastoma: a new example of melanotic neuroepithelial neoplasm. (7074529)
1982
49
Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model. (7105037)
1982
50
Multiple tumors of the sympathetic nervous system: Report of a case showing a distinct ganglioneuroma, a neuroblastoma and a cystic calcifying ganglioneuroblastoma. (19970419)
1938

Variations for Neuroblastoma

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Expression for genes affiliated with Neuroblastoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroblastoma

Search GEO for disease gene expression data for Neuroblastoma.

Pathways for genes affiliated with Neuroblastoma

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Compounds for genes affiliated with Neuroblastoma

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46Novoseek, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 3BitterDB
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Compounds related to Neuroblastoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1paraffin4610.8NME1, ALK, TOP2A, MYCN, TP73
2doxorubicin46 52 1212.7TP73, MYCN, TOP2A, ALK
3vincristine46 52 1212.7TP73, MYCN, TOP2A
4p0024610.7NME1, TOP2A, TP73
5adriamycin4610.6TOP2A, MYCN, TP73
6cisplatin46 52 62 1213.6TP73, MYCN, TOP2A, NME1
7tyrosine4610.6PHOX2B, NME1, ALK, TOP2A, MYCN, TP73
817-(allylamino)-17-demethoxygeldanamycin4610.5NME1, ALK
95fluorouracil4610.4TP73, TOP2A, NME1
10chloramphenicol46 3 52 1213.2TOP2A, MYCN, TP73

GO Terms for genes affiliated with Neuroblastoma

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17Gene Ontology
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Cellular components related to Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573710.6UBE4B, NME1, LIN28B, NBPF10, NBPF12, NBPF15

Biological processes related to Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hippocampus developmentGO:02176610.5NME1, TP73
2neuron developmentGO:04866610.2ALK, TP73

Molecular functions related to Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II regulatory region sequence-specific DNA bindingGO:00097710.5PHOX2B, NME1

Products for genes affiliated with Neuroblastoma

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Sources for Neuroblastoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet