NB
MCID: NRB001
MIFTS: 71

Neuroblastoma (NB) malady

Neuronal diseases, Cancer diseases categories

Summaries for Neuroblastoma

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Sources:
21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  it occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  it is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).  the symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  it affects one out of 100,000 children.  the exact cause of this tumor is not yet known.  neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (mri), or computed tomography (ct) scans; and a biopsy.  treatment depends on the size and location of the tumor within the body, as well as the child’s age. surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases. last updated: 10/7/2011

MalaCards: Neuroblastoma, also known as neural crest tumor, is related to adrenal neuroblastoma and lung cancer, and has symptoms including autosomal dominant inheritance, central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer and organic acid metabolism anomalies. An important gene associated with Neuroblastoma is NME1 (NME/NM23 nucleoside diphosphate kinase 1). The compounds paraffin and doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, bone and testes.

Genetics Home Reference:21 Neuroblastoma is a type of cancer that most often affects children. Neuroblastoma occurs when immature nerve cells called neuroblasts become abnormal and multiply uncontrollably to form a tumor. Most commonly, the tumor originates in the nerve tissue of the adrenal gland located above each kidney. Other common sites for tumors to form include the nerve tissue in the abdomen, chest, neck, or pelvis. Neuroblastoma can spread (metastasize) to other parts of the body such as the bones, liver, or skin.

MedlinePlus:33 Neuroblastoma is a cancer that forms in your nerve tissue. it usually begins in the adrenal glands, which sit atop your kidneys. it may also begin in your neck, chest or spinal cord. the cancer often begins in early childhood. sometimes it begins before a child is born. by the time doctors find the cancer, it has usually spread to other parts of the body. the most common symptoms are a lump in the abdomen, neck or chest bulging eyes dark circles around the eyes bone pain swollen stomach and trouble breathing in babies painless, bluish lumps under the skin in babies inability to move a body part treatments include surgery, radiation therapy, chemotherapy, biologic therapy, or a combination. biologic therapy boosts your body's own ability to fight cancer. sometimes before giving treatment, doctors wait to see whether symptoms get worse. this is called watchful waiting. nih: national cancer institute

Wikipedia:63 Neuroblastoma (NB) is the most common extracranial solid cancer in childhood and the most common cancer... more...

Description from OMIM:46 256700, 613013, 613014, 613015, 613016 613017 more

Aliases & Classifications for Neuroblastoma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 46OMIM, 10DISEASES, 48Orphanet, 33MedlinePlus, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
neuroblastoma:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Childhood; Age of death: Child / adolescent


Aliases & Descriptions:

neuroblastoma 8 9 42 22 21 46 10 48 33
neural crest tumor 48 60
sympathicoblastoma 8 60
nb 42 21
central neuroblastoma 60
neuroblastoma nos 8
sympathoblastoma 48


External Ids:

Disease Ontology8 DOID:769
NCIt39 C3270
MeSH34 D009447
MESH via Orphanet35 C536408, D009447
ICD10 via Orphanet26 C47
SNOMED-CT via Orphanet57 432328008, 87364003
UMLS via Orphanet61 C0027819, C2931189

Related Diseases for Neuroblastoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Neuroblastoma:



Diseases related to neuroblastoma

Clinical Features for Neuroblastoma

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

256700,613013,613014,613015,613016,613017

Symptoms:

48
  • autosomal dominant inheritance
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • organic acid metabolism anomalies

Drugs & Therapeutics for Neuroblastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Neuroblastoma

Drug clinical trials:

Search ClinicalTrials for Neuroblastoma

Search NIH Clinical Center for Neuroblastoma

Search CenterWatch for Neuroblastoma

Genetic Tests for Neuroblastoma

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22GTR
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Genetic tests related to Neuroblastoma:

id Genetic test Affiliating Genes
1 Neuroblastoma22

Anatomical Context for Neuroblastoma

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32MalaCards
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MalaCards organs/tissues related to Neuroblastoma:

32
Adrenal gland, Bone, Testes, Kidney, Eye, Skin, Liver, Bone marrow, Brain, Spinal cord, Endothelial, Pituitary, Lung, T cells, Thyroid, Lymph node, Breast, Nk cells, Monocytes, Prostate, Colon, Ovary, Smooth muscle, Cerebellum, Fetal brain, B cells, Parietal lobe, Dorsal root ganglion, Myeloid, Testis, Placenta, Salivary gland, Pancreas, Skeletal muscle, Heart

Animal Models for Neuroblastoma or affiliated genes

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Publications for Neuroblastoma

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50PubMed
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Articles related to Neuroblastoma:

(show top 50)    (show all 4239)
idTitleAuthorsYear
1
Neuroblastoma mistaken for acute leukemia based on bone marrow morphology. (24034124)
2013
2
Breakpoint features of genomic rearrangements in neuroblastoma with unbalanced translocations and chromothripsis. (23991058)
2013
3
Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy. (23619395)
2013
4
Comparative analysis of some aspects of mitochondrial metabolism in differentiated and undifferentiated neuroblastoma cells. (24072403)
2013
5
Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growth in vitro and in vivo. (22949014)
2013
6
Intratumoral treatment of smaller mouse neuroblastoma tumors with a recombinant protein consisting of IL-2 linked to the hu14.18 antibody increases intratumoral CD8+ T and NK cells and improves survival. (23661160)
2013
7
Anti-tumor activity of the beta-adrenergic receptor antagonist propranolol in neuroblastoma. (24389287)
2013
8
A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling. (24003223)
2013
9
Abdominal radiotherapy: a major determinant of metabolic syndrome in nephroblastoma and neuroblastoma survivors. (23251703)
2012
10
MiR-27b targets PPARI^ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells. (22120719)
2012
11
Preliminary study on the evaluation of olfactory neuroblastoma using PET/CT. (21892040)
2011
12
Induction of GM1a/GD1b synthase triggers complex ganglioside expression and alters neuroblastoma cell behavior; a new tumor cell model of ganglioside function. (21519903)
2011
13
Simultaneous occurrence of pancreatoblastoma and neuroblastoma in a newborn with beckwith-wiedemann syndrome. (20495482)
2010
14
HIF-2alpha maintains an undifferentiated state in neural crest-like human neuroblastoma tumor-initiating cells. (19805377)
2009
15
Comparison of iodine-123 metaiodobenzylguanidine (MIBG) scan and [18F]fluorodeoxyglucose positron emission tomography to evaluate response after iodine-131 MIBG therapy for relapsed neuroblastoma. (19805691)
2009
16
Cyclooxygenase inhibitors differentially modulate p73 isoforms in neuroblastoma. (19363520)
2009
17
Differentiating neuroblastoma arising in mediastinal germ cell tumour. (18631196)
2008
18
Detection of MYCN mRNA in neuroblastoma cell lines by quantitative RT-PCR]. (17306077)
2007
19
Olfactory neuroblastoma. (17044420)
2006
20
Capacitative Ca2+ entry is involved in regulating soluble amyloid precursor protein (sAPPalpha) release mediated by muscarinic acetylcholine receptor activation in neuroblastoma SH-SY5Y cells. (16524374)
2006
21
Effect of STI-571 (imatinib mesylate) in combination with retinoic acid and gamma-irradiation on viability of neuroblastoma cells. (16524560)
2006
22
S100B protects LAN-5 neuroblastoma cells against Abeta amyloid-induced neurotoxicity via RAGE engagement at low doses but increases Abeta amyloid neurotoxicity at high doses. (16477616)
2006
23
Loss of caspase-8 expression does not correlate with MYCN amplification, aggressive disease, or prognosis in neuroblastoma. (17047064)
2006
24
Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors. (15778293)
2005
25
Insulin-like growth factor-I induces the phosphorylation and nuclear exclusion of forkhead transcription factors in human neuroblastoma cells. (16133873)
2005
26
Inhibition of neuropathy target esterase expressing by antisense RNA does not affect neural differentiation in human neuroblastoma (SK-N-SH) cell line. (16010971)
2005
27
The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo. (14970234)
2004
28
Abeta production as consequence of cellular death of a human neuroblastoma overexpressing APP. (15251450)
2004
29
GABAergic system gene expression predicts clinical outcome in patients with neuroblastoma. (15483022)
2004
30
Amyloid-beta increases acetylcholinesterase expression in neuroblastoma cells by reducing enzyme degradation. (12871588)
2003
31
Negative autoregulation of p73 and p53 by DeltaNp73 in regulating differentiation and survival of human neuroblastoma cells. (12880968)
2003
32
N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells. (12085233)
2002
33
Interleukin-1beta induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells: implications for Alzheimer's disease. (11250126)
2001
34
Expression of P27(KIP1) is prognostic and independent of MYCN amplification in human neuroblastoma. (11307151)
2001
35
Value of 123I-MIBG scanning, neuron-specific enolase and serum ferritin in the diagnosis and follow-up of patients with neuroblastoma]. (11470071)
2001
36
Cholinesterases modulate cell adhesion in human neuroblastoma cells in vitro. (11154847)
2000
37
Phenotypic and genotypic diversity of human neuroblastoma studied in three IGR cell line models derived from bone marrow metastases. (10686938)
1999
38
p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent. (10023682)
1999
39
MYCN protein expression as a predictor of neuroblastoma prognosis. (9815553)
1997
40
Homozygous deletion of the neurofibromatosis-1 gene in the tumor of a patient with neuroblastoma. (9169039)
1997
41
Successful multidrug chemotherapy of olfactory neuroblastoma in an 8-year-old child. (8721037)
1996
42
Retinoic acid-induced increase in delta-opioid receptor and N-methyl-D-aspartate receptor mRNA levels in neuroblastoma x glioma (NG108-15) cells. (8866697)
1996
43
Adrenomedullin in human brain, adrenal glands and tumor tissues of pheochromocytoma, ganglioneuroblastoma and neuroblastoma. (7745031)
1995
44
CD44 expression and modulation on human neuroblastoma tumours and cell lines. (7576948)
1995
45
Agonist regulation of cellular Gs alpha-subunit levels in neuroblastoma x glioma hybrid NG108-15 cells transfected to express different levels of the human beta 2 adrenoceptor. (7516655)
1994
46
Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma. (8441429)
1993
47
Primary extracranial neuroblastoma with central nervous system metastases characterization by clinicopathologic findings and neuroimaging. (1913549)
1991
48
Increased expression of the MYCN oncogene in human neuroblastoma cells and possible, new therapeutic approaches]. (1942938)
1991
49
Comparison of binding affinities and adenylate cyclase inhibition for the determination of efficacy at mu-opioid receptors in a neuroblastoma cell line. (1652090)
1990
50
Olfactory neuroblastoma. (1127329)
1975

Genetic Variations for Neuroblastoma

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Expression for genes affiliated with Neuroblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroblastoma

Search GEO for disease gene expression data for Neuroblastoma.

Pathways for genes affiliated with Neuroblastoma

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Compounds for genes affiliated with Neuroblastoma

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Neuroblastoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1paraffin4411.6TP73, ALK, NME1, MYCN, TOP2A
2doxorubicin44 49 1113.2TOP2A, MYCN, ALK, TP73
3vincristine44 49 1113.1TOP2A, MYCN, TP73
4adriamycin4411.1TP73, MYCN, TOP2A
5p0024410.8TP73, NME1, TOP2A

GO Terms for genes affiliated with Neuroblastoma

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16Gene Ontology
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Cellular components related to Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573712.8NBPF8, LIN28B, NME1, NBAS, NBPF15, NBPF3

Molecular functions related to Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II regulatory region sequence-specific DNA bindingGO:00097710.9NME1, PHOX2B

Products for genes affiliated with Neuroblastoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neuroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet