|
NB
MCID: NRB001
|
Neuroblastoma malady |
|
Sources: 30NIH Rare Diseases, 23MedlinePlus, 17Genetics Home Reference, 44Wikipedia, 22MalaCards See all sources Export this MalaCard |
NIH Rare Diseases: Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5. It occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body. It is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes). The symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell. It affects one out of 100,000 children. The exact cause of this tumor is not yet known. Neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (MRI), or computed tomography (CT) scans; and a biopsy. Treatment depends on the size and location of the tumor within the body, as well as the child’s age. Surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases.30
MalaCards: Neuroblastoma, also known as sympathicoblastoma, is related to carcinoma and neuronitis. An important gene associated with Neuroblastoma is MYCN (v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)), and among its related pathways are Molecular Mechanisms of Cancer and p38 Signaling. The compounds tyrosine and serine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and cerebellum, and related mouse phenotypes are homeostasis/metabolism and mortality/aging. MedlinePlus: Neuroblastoma is a cancer that forms in your nerve tissue. it usually begins in the adrenal glands, which sit atop your kidneys. it may also begin in your neck, chest or spinal cord. the cancer often begins in early childhood. sometimes it begins before a child is born. by the time doctors find the cancer, it has usually spread to other parts of the body. the most common symptoms are a lump in the abdomen, neck or chest bulging eyes dark circles around the eyes bone pain swollen stomach and trouble breathing in babies painless, bluish lumps under the skin in babies inability to move a body part treatments include surgery, radiation therapy, chemotherapy or a combination. sometimes before giving treatment, doctors wait to see whether symptoms get worse. this is called watchful waiting. nih: national cancer institute23 Genetics Home Reference: Neuroblastoma is a type of cancer that most often affects children. Neuroblastoma occurs when immature nerve cells called neuroblasts become abnormal and multiply uncontrollably to form a tumor. Most commonly, the tumor originates in the nerve tissue of the adrenal gland located above each kidney. Other common sites for tumors to form include the nerve tissue in the abdomen, chest, neck, or pelvis. Neuroblastoma can spread (metastasize) to other parts of the body such as the bones, liver, or skin.17 Wikipedia: Neuroblastoma (N.B.) is the most common extracranial solid cancer in childhood and the most common...44 more... |
|
Sources: 6Disease Ontology, 7diseasecard, 30NIH Rare Diseases, 17Genetics Home Reference, 8DISEASES, 33OMIM, 23MedlinePlus, 43UMLS, 27NCIt, 40SNOMED-CT, 24MeSH See all sources |
|
|
|
Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for neuroblastoma Drug clinical trials:Search ClinicalTrials for neuroblastoma Search NIH Clinical Center for neuroblastoma Search CenterWatch for neuroblastoma |
|
|
|
Sources: 22MalaCards See all sources |
MalaCards organs/tissues related to neuroblastoma:22Bone marrow, Brain, Cerebellum, Spinal cord, Smooth muscle, Skeletal muscle, Small intestine, Colon, Kidney, Liver, Lung, Thyroid, Adrenal gland, Breast, Skin, Ovary, Prostate, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Ciliary ganglion, Dorsal root ganglion, Fetal liver, Fetal lung, Fetal thyroid, Pituitary
|
|
Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to neuroblastoma:25 (show all 30)
|
|
Sources: 35PubMed See all sources |
Articles related to neuroblastoma:(show top 50) (show all 2708)
|
|
Sources: 1BioGPS See all sources |
  |
|
Sources: 36QIAGEN, 20KEGG, 3Cell Signaling Technology, 41Thomson Reuters, 10EMD Millipore, 34PharmGKB See all sources |
Pathways related to neuroblastoma according to GeneDecks:(show top 50) (show all 360)
|
|
Sources: 32Novoseek , 18HMDB, 9DrugBank, 42Tocris Bioscience, 34PharmGKB See all sources |
Compounds related to neuroblastoma according to GeneDecks:(show top 50) (show all 453)
|
|
Sources: 12Gene Ontology See all sources |
Cellular components related to neuroblastoma according to GeneDecks:(show all 18)
Biological processes related to neuroblastoma according to GeneDecks:(show top 50) (show all 86)
Molecular functions related to neuroblastoma according to GeneDecks:(show all 19)
|