NB
MCID: NRB001
MIFTS: 60

Neuroblastoma (NB) malady

Neuronal, Cancer categories

Summaries for Neuroblastoma

Sources:
21Genetics Home Reference, 43NIH Rare Diseases, 34MedlinePlus, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Neuroblastoma is a tumor that develops from a nerve in a child, usually before the age of 5.  it occurs in the abdomen near the adrenal glands, but it can also occur in other parts of the body.  it is considered an aggressive tumor because it often spreads to other parts of the body (metastasizes).  the symptoms of a neuroblastoma may include a lump in the abdomen, pain, diarrhea, or generally feeling unwell.  it affects one out of 100,000 children.  the exact cause of this tumor is not yet known.  neuroblastoma may be diagnosed by physical examination; specific blood tests; imaging tests such as x-rays, magnetic resonance imaging (mri), or computed tomography (ct) scans; and a biopsy.  treatment depends on the size and location of the tumor within the body, as well as the child’s age. surgery is often the first step of treatment, and may be followed by chemotherapy, radiation therapy, or a stem cell transplant in more severe cases. last updated: 10/7/2011

MalaCards: Neuroblastoma, also known as neural crest tumor, is related to adrenal neuroblastoma and wilms tumor, and has symptoms including organic acid metabolism anomalies, central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer and autosomal dominant inheritance. An important gene associated with Neuroblastoma is NME1 (NME/NM23 nucleoside diphosphate kinase 1). The compounds paraffin and doxorubicin have been mentioned in the context of this disorder.

Genetics Home Reference:21 Neuroblastoma is a type of cancer that most often affects children. Neuroblastoma occurs when immature nerve cells called neuroblasts become abnormal and multiply uncontrollably to form a tumor. Most commonly, the tumor originates in the nerve tissue of the adrenal gland located above each kidney. Other common sites for tumors to form include the nerve tissue in the abdomen, chest, neck, or pelvis. Neuroblastoma can spread (metastasize) to other parts of the body such as the bones, liver, or skin.

MedlinePlus:34 Neuroblastoma is a cancer that forms in your nerve tissue. it usually begins in the adrenal glands, which sit atop your kidneys. it may also begin in your neck, chest or spinal cord. the cancer often begins in early childhood. sometimes it begins before a child is born. by the time doctors find the cancer, it has usually spread to other parts of the body. the most common symptoms are a lump in the abdomen, neck or chest bulging eyes dark circles around the eyes bone pain swollen stomach and trouble breathing in babies painless, bluish lumps under the skin in babies inability to move a body part treatments include surgery, radiation therapy, chemotherapy, biologic therapy, or a combination. biologic therapy boosts your body's own ability to fight cancer. sometimes before giving treatment, doctors wait to see whether symptoms get worse. this is called watchful waiting. nih: national cancer institute

Wikipedia:64 Neuroblastoma (NB) is the most common extracranial solid cancer in childhood and the most common cancer... more...

Description from OMIM:47 256700, 613013, 613014, 613015, 613016 613017 more

Aliases & Classifications for Neuroblastoma

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 47OMIM, 10DISEASES, 49Orphanet, 34MedlinePlus, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
neuroblastoma:
Inheritance: Sporadic; Prevalence: 1-5/10000; Age of onset: Childhood; Age of death: Child / adolescent


Aliases & Descriptions:

neuroblastoma 8 9 43 22 21 47 10 49 34
neural crest tumor 49 61
sympathicoblastoma 8 61
nb 43 21
central neuroblastoma 61
neuroblastoma nos 8
sympathoblastoma 49


External Ids:

Disease Ontology8 DOID:769
NCIt40 C3270
MeSH35 D009447
MESH via Orphanet36 C536408, D009447
ICD10 via Orphanet26 C47
SNOMED-CT via Orphanet58 432328008, 87364003
UMLS via Orphanet62 C0027819, C2931189

Related Diseases for Neuroblastoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Neuroblastoma:



Diseases related to neuroblastoma

Clinical Features for Neuroblastoma

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

256700,613013,613014,613015,613016,613017

Symptoms:

49
  • organic acid metabolism anomalies
  • central nervous system/peripheral nerves neoplasm/tumor/carcinoma/cancer
  • autosomal dominant inheritance

Drugs & Therapeutics for Neuroblastoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Neuroblastoma

Drug clinical trials:

Search ClinicalTrials for Neuroblastoma

Search NIH Clinical Center for Neuroblastoma

Search CenterWatch for Neuroblastoma

Genetic Tests for Neuroblastoma

Sources:
22GTR
See all sources

Genetic tests related to Neuroblastoma:

id Genetic test Affiliating Genes
1 Neuroblastoma22

Anatomical Context for Neuroblastoma

Animal Models for Neuroblastoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Neuroblastoma

Sources:
51PubMed
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Articles related to Neuroblastoma:

(show top 50)    (show all 4244)
idTitleAuthorsYear
1
Glycogen synthase kinase-3 (GSK3) controls deoxyglucose-induced mitochondrial biogenesis in human neuroblastoma SH-SY5Y cells. (24316184)
2013
2
Expression of TWEAK/Fn14 in neuroblastoma: implications in tumorigenesis. (23443741)
2013
3
Neuroblastoma: developmental biology, cancer genomics and immunotherapy. (23702928)
2013
4
Study of the mechanisms underlying the reversal of multidrug resistance of human neuroblastoma multidrug-resistant cell line SK-N-SH/MDR1 by low-intensity pulsed ultrasound. (23483136)
2013
5
Chromosome imbalances and alterations of AURKA and MYCN genes in children with neuroblastoma. (23317189)
2012
6
Unexpectedly durable palliation of metastatic olfactory neuroblastoma using anti-angiogenic therapy with Bevacizumab. (22826790)
2012
7
Radiation-triggered tumor necrosis factor (TNF) alpha-NFkappaB cross-signaling favors survival advantage in human neuroblastoma cells. (21527635)
2011
8
A novel therapeutic combination for neuroblastoma: the vascular endothelial growth factor receptor/epidermal growth factor receptor/rearranged during transfection inhibitor vandetanib with 13-cis-retinoic acid. (20225331)
2010
9
Methylation of tumor-suppressor genes in neuroblastoma: The RASSF1A gene is almost always methylated in primary tumors. (17570703)
2008
10
ERAP140/Nbla10993 is a novel favorable prognostic indicator for neuroblastoma induced in response to retinoic acid. (18497940)
2008
11
Different kinases desensitize the human delta-opioid receptor (hDOP-R) in the neuroblastoma cell line SK-N-BE upon peptidic and alkaloid agonists. (18395423)
2008
12
Novel noncatalytic role for caspase-8 in promoting SRC-mediated adhesion and Erk signaling in neuroblastoma cells. (18089800)
2007
13
Phosphoproteomic profiling of human SH-SY5Y neuroblastoma cells during response to 6-hydroxydopamine-induced oxidative stress. (16949164)
2006
14
Signaling from p53 to NF-kappa B determines the chemotherapy responsiveness of neuroblastoma. (17215959)
2006
15
Enhanced ERK dependent CREB activation reduces apoptosis in staurosporine-treated human neuroblastoma SK-N-BE(2)C cells. (16678346)
2006
16
Increased malignant behavior in neuroblastoma cells with acquired multi-drug resistance does not depend on P-gp expression. (16142320)
2005
17
Differential induction of apoptosis by antidepressants in glioma and neuroblastoma cell lines: evidence for p-c-Jun, cytochrome c, and caspase-3 involvement. (16055945)
2005
18
Vitamin C blocks TNF-alpha-induced NF-kappaB activation and ICAM-1 expression in human neuroblastoma cells. (15554267)
2004
19
Hypoxia-induced erythropoietin expression in human neuroblastoma requires a methylation free HIF-1 binding site. (15352172)
2004
20
Olf/EBF proteins are expressed in neuroblastoma cells: potential regulators of the Chromogranin A and SCG10 promoters. (15054865)
2004
21
Expression of trkB in human neuroblastoma in relation to MYCN expression and retinoic acid treatment. (12808116)
2003
22
Induction of GADD153 and Bak: novel molecular targets of fenretinide-induced apoptosis of neuroblastoma. (12880976)
2003
23
Internalization of beta-amyloid causes downregulation of apolipoprotein E mRNA expression in neuroblastoma cells. (12661900)
2003
24
Adult neuroblastoma of the retroperitoneum and abdomen: clinicopathologic distinction from primitive neuroectodermal tumor. (11420463)
2001
25
A functional role for ERK in gene induction, but not in neurite outgrowth in differentiating neuroblastoma cells. (11281640)
2001
26
Maturation of mass-screened localized adrenal neuroblastoma. (11685689)
2001
27
Nociceptin-induced internalization of the ORL1 receptor in human neuroblastoma cells. (11568656)
2001
28
Retinoic acid induction of sialyltransferase activity in neuroblastoma cells of differing sialylation potentials. (11443279)
2000
29
Orexin-A in the human brain and tumor tissues of ganglioneuroblastoma and neuroblastoma. (10822113)
2000
30
Human gammadelta T lymphocytes exert natural and IL-2-induced cytotoxicity to neuroblastoma cells. (11001547)
2000
31
Resveratrol-induced activation of the mitogen-activated protein kinases, ERK1 and ERK2, in human neuroblastoma SH-SY5Y cells. (10320034)
1999
32
Frequent deregulation of p16 and the p16/G1 cell cycle-regulatory pathway in neuroblastoma. (9935245)
1999
33
Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists. (9930730)
1999
34
Influence of cisplatin and doxorubicin on 125I-meta-iodobenzylguanidine uptake in human neuroblastoma cell lines. (10615234)
1999
35
Binding of dihydroartemisinin to differentiating neuroblastoma cells and rat cortical homogenate. (9621346)
1998
36
Polysialylated neural cell adhesion molecule in childhood ganglioneuroma and neuroblastoma of different histological grade and clinical stage. (9860228)
1998
37
Isolated intracranial metastasis of neuroblastoma 2 years after completion of therapy. (9124060)
1997
38
The expression of the LDL receptor-related protein (LRP) correlates with the differentiation of human neuroblastoma cells. (9439808)
1997
39
The CD95 (APO-1/Fas) system mediates drug-induced apoptosis in neuroblastoma cells. (9288794)
1997
40
Phosphatidic acid activation of protein kinase C in LA-N-1 neuroblastoma cells. (8786839)
1995
41
SK-N-BE: a human neuroblastoma cell line containing two subtypes of delta-opioid receptors. (8113811)
1994
42
Corticotropin-releasing factor is secreted in the BE(2)-C neuroblastoma cell and is responsive to forskolin. (8196496)
1994
43
Modulation of alpha 1 beta 1, alpha 2 beta 1 and alpha 3 beta 1 integrin heterodimers during human neuroblastoma cell differentiation. (7691664)
1993
44
BQ-123, cyclo(-D-Trp-D-Asp-Pro-D-Val-Leu), is a non-competitive antagonist of the actions of endothelin-1 in SK-N-MC human neuroblastoma cells. (1567452)
1992
45
Carbachol stimulates binding of a photoreactive calmodulin derivative to calmodulin-binding proteins in intact SK-N-SH human neuroblastoma cells. (1556101)
1992
46
Detection of multiple hormones and their mRNAs in human neuroblastoma cell line NB-1 using in situ hybridization, immunocytochemistry and radioimmunoassay. (1279891)
1992
47
Down modulation of N-myc, heat-shock protein 70, and nucleolin during the differentiation of human neuroblastoma cells. (1657899)
1991
48
Sympathetic hyperplasia and neuroblastomas in transgenic mice expressing polyoma middle T antigen. (2088503)
1990
49
Left adrenal neuroblastoma with normal conventional radiologic studies: value of gray scale ultrasonography. (7361156)
1980
50
Association of congenital adrenal neuroblastoma with multiple anomalies including an unusual oropharyngeal cavity (imperforate buccopharyngeal membrane?). (14859198)
1951

Genetic Variations for Neuroblastoma

Expression for genes affiliated with Neuroblastoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroblastoma

Search GEO for disease gene expression data for Neuroblastoma.

Pathways for genes affiliated with Neuroblastoma

Compounds for genes affiliated with Neuroblastoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank
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Compounds related to Neuroblastoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1paraffin4511.6TP73, ALK, NME1, MYCN, TOP2A
2doxorubicin45 50 1113.2TOP2A, ALK, TP73, MYCN
3vincristine45 50 1113.1TP73, TOP2A, MYCN
4adriamycin4511.1TOP2A, MYCN, TP73
5p0024510.8NME1, TP73, TOP2A

GO Terms for genes affiliated with Neuroblastoma

Sources:
16Gene Ontology
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Cellular components related to Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573712.8NBPF8, LIN28B, NME1, NBAS, NBPF15, NBPF3

Molecular functions related to Neuroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II regulatory region sequence-specific DNA bindingGO:00097710.9NME1, PHOX2B

Products for genes affiliated with Neuroblastoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neuroblastoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet