MCID: NRB002
MIFTS: 26

Neuroblastoma, Susceptibility malady

Genetic diseases (common), Neuronal diseases categories

Summaries for Neuroblastoma, Susceptibility

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34MalaCards
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MalaCards: Neuroblastoma, Susceptibility is related to neuroblastoma and alk-related neuroblastoma susceptibility. An important gene associated with Neuroblastoma, Susceptibility is PHOX2B (paired-like homeobox 2b), and among its related pathways are Cell cycle Spindle assembly and chromosome separation and Cell cycle Role of APC in cell cycle regulation. The compounds sns 314 mesylate and cct 137690 have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and embryogenesis.

Aliases & Classifications for Neuroblastoma, Susceptibility

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21GeneTests
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroblastoma, susceptibility 21


Related Diseases for Neuroblastoma, Susceptibility

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18GeneCards, 19GeneDecks
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Graphical network of diseases related to Neuroblastoma, Susceptibility:



Diseases related to neuroblastoma, susceptibility

Symptoms for Neuroblastoma, Susceptibility

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Drugs & Therapeutics for Neuroblastoma, Susceptibility

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Neuroblastoma, Susceptibility

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Genetic Tests for Neuroblastoma, Susceptibility

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21GeneTests
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Genetic tests related to Neuroblastoma, Susceptibility:

id Genetic test Affiliating Genes
1 Neuroblastoma, Susceptibility21 PHOX2B

Anatomical Context for Neuroblastoma, Susceptibility

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Animal Models for Neuroblastoma, Susceptibility or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Neuroblastoma, Susceptibility:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4AURKA, AURKB, BARD1, NME1
2MP:00053808.3PHOX2B, NME1, BARD1, AURKB, AURKA
3MP:00107688.1PHOX2B, NME1, BARD1, KIF1B, AURKB, AURKA

Publications for Neuroblastoma, Susceptibility

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53PubMed
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Articles related to Neuroblastoma, Susceptibility:

idTitleAuthorsYear
1
Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. (22350409)
2012
2
ALK-Related Neuroblastoma Susceptibility (20301782)
1993

Variations for Neuroblastoma, Susceptibility

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Expression for genes affiliated with Neuroblastoma, Susceptibility

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroblastoma, Susceptibility

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Pathways for genes affiliated with Neuroblastoma, Susceptibility

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51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database
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Pathways related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6AURKB, AURKA
29.6AURKB, AURKA
3
Show member pathways
Signaling by Aurora kinases39
Aurora C signaling39
9.6AURKA, AURKB
49.6AURKB, AURKA
59.6AURKB, AURKA

Compounds for genes affiliated with Neuroblastoma, Susceptibility

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Sources:
62Tocris Bioscience, 46Novoseek, 30IUPHAR, 25HMDB, 12DrugBank
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Compounds related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sns 314 mesylate629.8AURKB, AURKA
2cct 137690629.8AURKA, AURKB
3tc-a 2317 hydrochloride629.8AURKA, AURKB
4anacardic acid629.7AURKA, AURKB
5hesperadin hydrochloride629.7AURKA, AURKB
617-(allylamino)-17-demethoxygeldanamycin469.5NME1, ALK
7aspartate469.3NME1, ALK, AURKA
8adp46 30 2510.9AURKA, AURKB, ALK, NME1
9Adenosine triphosphate25 129.8AURKA, AURKB, ALK, NME1

GO Terms for genes affiliated with Neuroblastoma, Susceptibility

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17Gene Ontology
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Biological processes related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spindle stabilizationGO:0431469.6AURKB, AURKA
2anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processGO:0311459.6AURKB, AURKA
3negative regulation of protein bindingGO:0320919.3AURKB, AURKA
4protein autophosphorylationGO:0467779.2ALK, AURKB, AURKA

Molecular functions related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II regulatory region sequence-specific DNA bindingGO:0009779.8PHOX2B, NME1
2protein serine/threonine/tyrosine kinase activityGO:0047129.3AURKB, AURKA
3ATP bindingGO:0055248.5NME1, KIF1B, ALK, AURKB, AURKA

Products for genes affiliated with Neuroblastoma, Susceptibility

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Neuroblastoma, Susceptibility

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet