MCID: NRB002
MIFTS: 22

Neuroblastoma, Susceptibility malady

Genetic diseases (common), Neuronal diseases categories

Aliases & Classifications for Neuroblastoma, Susceptibility

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Aliases & Descriptions for Neuroblastoma, Susceptibility:

Name: Neuroblastoma, Susceptibility 20


Classifications:



Summaries for Neuroblastoma, Susceptibility

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MalaCards based summary: Neuroblastoma, Susceptibility is related to neuroblastoma and alk-related neuroblastoma susceptibility. An important gene associated with Neuroblastoma, Susceptibility is PHOX2B (paired-like homeobox 2b), and among its related pathways are Cell cycle Spindle assembly and chromosome separation and Cell cycle Role of APC in cell cycle regulation. The compounds sns 314 mesylate and cct 137690 have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and embryogenesis.

Related Diseases for Neuroblastoma, Susceptibility

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Graphical network of diseases related to Neuroblastoma, Susceptibility:



Diseases related to neuroblastoma, susceptibility

Symptoms for Neuroblastoma, Susceptibility

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Drugs & Therapeutics for Neuroblastoma, Susceptibility

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Drug clinical trials:

Search ClinicalTrials for Neuroblastoma, Susceptibility

Search NIH Clinical Center for Neuroblastoma, Susceptibility

Genetic Tests for Neuroblastoma, Susceptibility

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Genetic tests related to Neuroblastoma, Susceptibility:

id Genetic test Affiliating Genes
1 Neuroblastoma, Susceptibility20 PHOX2B

Anatomical Context for Neuroblastoma, Susceptibility

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Animal Models for Neuroblastoma, Susceptibility or affiliated genes

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MGI Mouse Phenotypes related to Neuroblastoma, Susceptibility:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4AURKA, AURKB, BARD1, NME1
2MP:00053808.3PHOX2B, NME1, BARD1, AURKB, AURKA
3MP:00107688.1PHOX2B, NME1, BARD1, KIF1B, AURKB, AURKA

Publications for Neuroblastoma, Susceptibility

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Articles related to Neuroblastoma, Susceptibility:

idTitleAuthorsYear
1
Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. (22350409)
2012
2
ALK-Related Neuroblastoma Susceptibility (20301782)
1993

Variations for Neuroblastoma, Susceptibility

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Expression for genes affiliated with Neuroblastoma, Susceptibility

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Search GEO for disease gene expression data for Neuroblastoma, Susceptibility.

Pathways for genes affiliated with Neuroblastoma, Susceptibility

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Pathways related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6AURKB, AURKA
29.6AURKB, AURKA
3
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.6AURKA, AURKB
49.6AURKB, AURKA
59.6AURKB, AURKA

Compounds for genes affiliated with Neuroblastoma, Susceptibility

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Sources:
60Tocris Bioscience, 44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank
See all sources

Compounds related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1sns 314 mesylate609.8AURKB, AURKA
2cct 137690609.8AURKA, AURKB
3tc-a 2317 hydrochloride609.8AURKA, AURKB
4anacardic acid609.7AURKA, AURKB
5hesperadin hydrochloride609.7AURKA, AURKB
617-(allylamino)-17-demethoxygeldanamycin449.5NME1, ALK
7aspartate449.3NME1, ALK, AURKA
8adp44 28 2410.9AURKA, AURKB, ALK, NME1
9Adenosine triphosphate24 119.8AURKA, AURKB, ALK, NME1

GO Terms for genes affiliated with Neuroblastoma, Susceptibility

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Biological processes related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1spindle stabilizationGO:00431469.6AURKB, AURKA
2anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processGO:00311459.6AURKB, AURKA
3negative regulation of protein bindingGO:00320919.3AURKB, AURKA
4protein autophosphorylationGO:00467779.2ALK, AURKB, AURKA

Molecular functions related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II regulatory region sequence-specific DNA bindingGO:00009779.8PHOX2B, NME1
2protein serine/threonine/tyrosine kinase activityGO:00047129.3AURKB, AURKA
3ATP bindingGO:00055248.5NME1, KIF1B, ALK, AURKB, AURKA

Sources for Neuroblastoma, Susceptibility

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet