MCID: NRB002
MIFTS: 25

Neuroblastoma, Susceptibility malady

Genetic diseases (common), Neuronal diseases categories
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Summaries for Neuroblastoma, Susceptibility

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MalaCards based summary: Neuroblastoma, Susceptibility is related to neuroblastoma and alk-related neuroblastoma susceptibility. An important gene associated with Neuroblastoma, Susceptibility is PHOX2B (paired-like homeobox 2b), and among its related pathways are Cell cycle Spindle assembly and chromosome separation and Cell cycle Role of APC in cell cycle regulation. The compounds sns 314 mesylate and cct 137690 have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and embryogenesis.

Aliases & Classifications for Neuroblastoma, Susceptibility

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Neuroblastoma, Susceptibility, Aliases & Descriptions:

Name: Neuroblastoma, Susceptibility 20


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Neuronal diseases


Related Diseases for Neuroblastoma, Susceptibility

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Graphical network of diseases related to Neuroblastoma, Susceptibility:



Diseases related to neuroblastoma, susceptibility

Symptoms for Neuroblastoma, Susceptibility

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Drugs & Therapeutics for Neuroblastoma, Susceptibility

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Drug clinical trials:

Search ClinicalTrials for Neuroblastoma, Susceptibility

Search NIH Clinical Center for Neuroblastoma, Susceptibility

Genetic Tests for Neuroblastoma, Susceptibility

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Genetic tests related to Neuroblastoma, Susceptibility:

id Genetic test Affiliating Genes
1 Neuroblastoma, Susceptibility20 PHOX2B

Anatomical Context for Neuroblastoma, Susceptibility

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Animal Models for Neuroblastoma, Susceptibility or affiliated genes

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MGI Mouse Phenotypes related to Neuroblastoma, Susceptibility:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4AURKA, AURKB, BARD1, NME1
2MP:00053808.3PHOX2B, NME1, BARD1, AURKB, AURKA
3MP:00107688.1PHOX2B, NME1, BARD1, KIF1B, AURKB, AURKA

Publications for Neuroblastoma, Susceptibility

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Articles related to Neuroblastoma, Susceptibility:

idTitleAuthorsYear
1
ALK-Related Neuroblastoma Susceptibility (20301782)
1993

Variations for Neuroblastoma, Susceptibility

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Expression for genes affiliated with Neuroblastoma, Susceptibility

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Expression patterns in normal tissues for genes affiliated with Neuroblastoma, Susceptibility

Search GEO for disease gene expression data for Neuroblastoma, Susceptibility.

Pathways for genes affiliated with Neuroblastoma, Susceptibility

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Pathways related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6AURKB, AURKA
29.6AURKB, AURKA
3
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.6AURKA, AURKB
49.6AURKB, AURKA
59.6AURKB, AURKA

Compounds for genes affiliated with Neuroblastoma, Susceptibility

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Sources:
61Tocris Bioscience, 44Novoseek, 28IUPHAR, 24HMDB, 11DrugBank
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Compounds related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sns 314 mesylate619.8AURKB, AURKA
2cct 137690619.8AURKA, AURKB
3tc-a 2317 hydrochloride619.8AURKA, AURKB
4anacardic acid619.7AURKA, AURKB
5hesperadin hydrochloride619.7AURKA, AURKB
617-(allylamino)-17-demethoxygeldanamycin449.5NME1, ALK
7aspartate449.3NME1, ALK, AURKA
8adp44 28 2410.9AURKA, AURKB, ALK, NME1
9Adenosine triphosphate24 119.8AURKA, AURKB, ALK, NME1

GO Terms for genes affiliated with Neuroblastoma, Susceptibility

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Biological processes related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spindle stabilizationGO:0431469.6AURKB, AURKA
2anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processGO:0311459.6AURKB, AURKA
3negative regulation of protein bindingGO:0320919.3AURKB, AURKA
4protein autophosphorylationGO:0467779.2ALK, AURKB, AURKA

Molecular functions related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II regulatory region sequence-specific DNA bindingGO:0009779.8PHOX2B, NME1
2protein serine/threonine/tyrosine kinase activityGO:0047129.3AURKB, AURKA
3ATP bindingGO:0055248.5NME1, KIF1B, ALK, AURKB, AURKA

Products for genes affiliated with Neuroblastoma, Susceptibility

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  • Antibodies
  • Proteins
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Sources for Neuroblastoma, Susceptibility

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet