MCID: NRB002
MIFTS: 22

Neuroblastoma, Susceptibility malady

Neuronal category

Summaries for Neuroblastoma, Susceptibility

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33MalaCards
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MalaCards: Neuroblastoma, Susceptibility is related to alk-related neuroblastoma susceptibility and phox2b-related neuroblastoma, susceptibility. An important gene associated with Neuroblastoma, Susceptibility is PHOX2B (paired-like homeobox 2b), and among its related pathways are Cell cycle Chromosome condensation in prometaphase and Cell cycle Role of APC in cell cycle regulation. The compounds sns 314 mesylate and cct 137690 have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and embryogenesis.

Aliases & Classifications for Neuroblastoma, Susceptibility

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20GeneTests
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

neuroblastoma, susceptibility 20


Related Diseases for Neuroblastoma, Susceptibility

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17GeneCards, 18GeneDecks
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Diseases related to Neuroblastoma, Susceptibility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1alk-related neuroblastoma susceptibility10.3
2phox2b-related neuroblastoma, susceptibility10.2
3kif1b-related neuroblastoma, susceptibility10.2
4neuroblastoma 110.0
5cervical cancer10.0NME1
6peripheral t-cell lymphoma10.0ALK, NME1
7laryngeal squamous cell carcinoma10.0AURKA, NME1
8benign mesothelioma10.0AURKB, AURKA
9neuroblastoma10.0PHOX2B, NME1, ALK
10bladder carcinoma10.0ALK, AURKA
11ovarian cancer10.0BARD1, NME1, AURKA

Graphical network of diseases related to Neuroblastoma, Susceptibility:



Diseases related to neuroblastoma, susceptibility

Clinical Features for Neuroblastoma, Susceptibility

Drugs & Therapeutics for Neuroblastoma, Susceptibility

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5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Neuroblastoma, Susceptibility

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Genetic Tests for Neuroblastoma, Susceptibility

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20GeneTests
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Genetic tests related to Neuroblastoma, Susceptibility:

id Genetic test Affiliating Genes
1 Neuroblastoma, Susceptibility20 PHOX2B

Anatomical Context for Neuroblastoma, Susceptibility

Animal Models for Neuroblastoma, Susceptibility or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Neuroblastoma, Susceptibility:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7NME1, BARD1, AURKB, AURKA
2MP:00053808.1NME1, BARD1, PHOX2B, AURKB, AURKA

Publications for Neuroblastoma, Susceptibility

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51PubMed
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Articles related to Neuroblastoma, Susceptibility:

(show all 13)
idTitleAuthorsYear
1
Replication of GWAS-identified neuroblastoma risk loci strengthens the role of BARD1 and affirms the cumulative effect of genetic variations on disease susceptibility. (23222812)
2013
2
Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma. (22941191)
2012
3
Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. (22350409)
2012
4
HLA-G polymorphisms, genetic susceptibility, and clinical outcome in childhood neuroblastoma. (22115424)
2011
5
Common variations in BARD1 influence susceptibility to high-risk neuroblastoma. (19412175)
2009
6
Metronomic scheduling of imatinib abrogates clonogenicity of neuroblastoma cells and enhances their susceptibility to selected chemotherapeutic drugs in vitro and in vivo. (19058199)
2009
7
Mitochondrial dysfunction enhances susceptibility to oxidative stress by down-regulation of thioredoxin in human neuroblastoma cells. (17616813)
2008
8
Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs. (16724269)
2006
9
Overexpression of amyloid precursor protein induces susceptibility to oxidative stress in human neuroblastoma SH-SY5Y cells. (15959846)
2006
10
Zinc deficiency increases the susceptibility of human neuroblastoma cells to lead-induced activator protein-1 activation. (16484283)
2006
11
Glutathione S-transferase polymorphisms and susceptibility to neuroblastoma. (15900216)
2005
12
Effect of culture age on the susceptibility of differentiating neuroblastoma cells to retinoid cytotoxicity. (18627021)
1996
13
ALK-Related Neuroblastoma Susceptibility (20301782)
1993

Genetic Variations for Neuroblastoma, Susceptibility

Expression for genes affiliated with Neuroblastoma, Susceptibility

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroblastoma, Susceptibility

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Pathways for genes affiliated with Neuroblastoma, Susceptibility

Sources:
12EMD Millipore, 38NCBI BioSystems Database
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Pathways related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7AURKA, AURKB
29.7AURKB, AURKA
39.7AURKB, AURKA
4
Hide members
9.7AURKB, AURKA
59.7AURKB, AURKA

Compounds for genes affiliated with Neuroblastoma, Susceptibility

Sources:
60Tocris Bioscience, 45Novoseek, 11DrugBank, 29IUPHAR, 24HMDB
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Compounds related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sns 314 mesylate609.9AURKB, AURKA
2cct 137690609.9AURKA, AURKB
3tc-a 2317 hydrochloride609.8AURKA, AURKB
4anacardic acid609.8AURKA, AURKB
5hesperadin hydrochloride609.8AURKA, AURKB
617-(allylamino)-17-demethoxygeldanamycin459.6NME1, ALK
7Adenosine-5'-Diphosphate119.5NME1, AURKA
8adp45 29 2410.7ALK, NME1, AURKB, AURKA
9Adenosine triphosphate11 249.5AURKA, AURKB, NME1, ALK

GO Terms for genes affiliated with Neuroblastoma, Susceptibility

Sources:
16Gene Ontology
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Biological processes related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein autophosphorylationGO:0467779.3ALK, AURKB, AURKA

Molecular functions related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein serine/threonine/tyrosine kinase activityGO:0047129.6AURKB, AURKA
2RNA polymerase II regulatory region sequence-specific DNA bindingGO:0009779.4NME1, PHOX2B
3ATP bindingGO:0055248.5ALK, KIF1B, NME1, AURKB, AURKA

Products for genes affiliated with Neuroblastoma, Susceptibility

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Sources for Neuroblastoma, Susceptibility

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet