MCID: NRB002
MIFTS: 21

Neuroblastoma, Susceptibility malady

Neuronal diseases category

Summaries for Neuroblastoma, Susceptibility

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32MalaCards
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MalaCards: Neuroblastoma, Susceptibility is related to neuroblastoma and alk-related neuroblastoma susceptibility. An important gene associated with Neuroblastoma, Susceptibility is PHOX2B (paired-like homeobox 2b), and among its related pathways are Cell cycle Chromosome condensation in prometaphase and Cell cycle Role of APC in cell cycle regulation. The compounds sns 314 mesylate and cct 137690 have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and embryogenesis.

Aliases & Classifications for Neuroblastoma, Susceptibility

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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroblastoma, susceptibility 20


Related Diseases for Neuroblastoma, Susceptibility

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17GeneCards, 18GeneDecks
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Graphical network of diseases related to Neuroblastoma, Susceptibility:



Diseases related to neuroblastoma, susceptibility

Clinical Features for Neuroblastoma, Susceptibility

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Drugs & Therapeutics for Neuroblastoma, Susceptibility

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neuroblastoma, Susceptibility

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20GeneTests
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Genetic tests related to Neuroblastoma, Susceptibility:

id Genetic test Affiliating Genes
1 Neuroblastoma, Susceptibility20 PHOX2B

Anatomical Context for Neuroblastoma, Susceptibility

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Animal Models for Neuroblastoma, Susceptibility or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuroblastoma, Susceptibility:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7NME1, BARD1, AURKB, AURKA
2MP:00053808.1NME1, BARD1, PHOX2B, AURKB, AURKA

Publications for Neuroblastoma, Susceptibility

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Genetic Variations for Neuroblastoma, Susceptibility

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Expression for genes affiliated with Neuroblastoma, Susceptibility

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroblastoma, Susceptibility

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Pathways for genes affiliated with Neuroblastoma, Susceptibility

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12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7AURKA, AURKB
29.7AURKB, AURKA
39.7AURKB, AURKA
4
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9.7AURKB, AURKA
59.7AURKB, AURKA

Compounds for genes affiliated with Neuroblastoma, Susceptibility

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59Tocris Bioscience, 44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB
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Compounds related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sns 314 mesylate599.9AURKB, AURKA
2cct 137690599.9AURKA, AURKB
3tc-a 2317 hydrochloride599.8AURKA, AURKB
4anacardic acid599.8AURKA, AURKB
5hesperadin hydrochloride599.8AURKA, AURKB
617-(allylamino)-17-demethoxygeldanamycin449.6NME1, ALK
7Adenosine-5'-Diphosphate119.5NME1, AURKA
8adp44 28 2410.7ALK, NME1, AURKB, AURKA
9Adenosine triphosphate11 249.5AURKA, AURKB, NME1, ALK

GO Terms for genes affiliated with Neuroblastoma, Susceptibility

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16Gene Ontology
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Biological processes related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein autophosphorylationGO:0467779.3ALK, AURKB, AURKA

Molecular functions related to Neuroblastoma, Susceptibility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein serine/threonine/tyrosine kinase activityGO:0047129.6AURKB, AURKA
2RNA polymerase II regulatory region sequence-specific DNA bindingGO:0009779.4NME1, PHOX2B
3ATP bindingGO:0055248.5ALK, KIF1B, NME1, AURKB, AURKA

Products for genes affiliated with Neuroblastoma, Susceptibility

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Sources for Neuroblastoma, Susceptibility

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet