MCID: NRB002
MIFTS: 24

Neuroblastoma, Susceptibility malady

Categories: Genetic diseases, Neuronal diseases

Aliases & Classifications for Neuroblastoma, Susceptibility

Aliases & Descriptions for Neuroblastoma, Susceptibility:

Name: Neuroblastoma, Susceptibility 24

Classifications:



Summaries for Neuroblastoma, Susceptibility

MalaCards based summary : Neuroblastoma, Susceptibility is related to neuroblastoma and alk-related neuroblastoma susceptibility. An important gene associated with Neuroblastoma, Susceptibility is PHOX2B (Paired Like Homeobox 2b), and among its related pathways/superpathways are Aurora B signaling and Cell cycle_Chromosome condensation in prometaphase. The drugs Lenograstim and Adjuvants, Immunologic have been mentioned in the context of this disorder. Related phenotypes are Decreased human cytomegalovirus (HCMV) strain AD169 replication and Decreased substrate adherent cell growth

Related Diseases for Neuroblastoma, Susceptibility

Graphical network of the top 20 diseases related to Neuroblastoma, Susceptibility:



Diseases related to Neuroblastoma, Susceptibility

Symptoms & Phenotypes for Neuroblastoma, Susceptibility

GenomeRNAi Phenotypes related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.26 ALK AURKA AURKB NME1
2 Decreased substrate adherent cell growth GR00193-A-1 9.02 AURKA
3 Decreased substrate adherent cell growth GR00193-A-2 9.02 ALK AURKA AURKB
4 Decreased substrate adherent cell growth GR00193-A-4 9.02 AURKB

MGI Mouse Phenotypes related to Neuroblastoma, Susceptibility:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.1 ALK AURKA AURKB BARD1 NME1 XPC

Drugs & Therapeutics for Neuroblastoma, Susceptibility

Drugs for Neuroblastoma, Susceptibility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved Phase 3 135968-09-1
2 Adjuvants, Immunologic Phase 3
3
Irinotecan Approved, Investigational Phase 1 97682-44-5, 100286-90-6 60838
4
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
5
Cefixime Approved Phase 1 79350-37-1 54362 5362065
6
Cefpodoxime Approved, Vet_approved Phase 1 82619-04-3, 80210-62-4 6335986
7
Camptothecin Experimental Phase 1 7689-03-4
8 topoisomerase I inhibitors Phase 1
9 Topoisomerase Inhibitors Phase 1
10 Antineoplastic Agents, Phytogenic Phase 1
11 Cefpodoxime proxetil Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Active, not recruiting NCT01987596 Phase 3
2 Study of Irinotecan and Bortezomib in Children With Recurrent/Refractory Neuroblastoma Active, not recruiting NCT00644696 Phase 1
3 Familial Investigations of Childhood Cancer Predisposition Recruiting NCT03050268
4 Genetic Biomarkers in Children With Neuroblastoma (Also Known as Neuroblastoma Epidemiology in North America [NENA]) Active, not recruiting NCT01119560
5 Genetic Analysis Using Blood or Bone Marrow From Participants With Neuroblastoma or Noncancerous Conditions Active, not recruiting NCT00436696
6 Genetic Susceptibility and Risk of Second Cancers in Patients Who Have Undergone Stem Cell Transplant for Cancer Active, not recruiting NCT00949052
7 Genomic Structural Variation in Cancer Susceptibility Enrolling by invitation NCT00996710

Search NIH Clinical Center for Neuroblastoma, Susceptibility

Genetic Tests for Neuroblastoma, Susceptibility

Genetic tests related to Neuroblastoma, Susceptibility:

id Genetic test Affiliating Genes
1 Neuroblastoma, Susceptibility 24 PHOX2B

Anatomical Context for Neuroblastoma, Susceptibility

Publications for Neuroblastoma, Susceptibility

Articles related to Neuroblastoma, Susceptibility:

id Title Authors Year
1
Lack of Associations between XPC Gene Polymorphisms and Neuroblastoma Susceptibility in a Chinese Population. ( 27847809 )
2016
2
The Association between GWAS-identified BARD1 Gene SNPs and Neuroblastoma Susceptibility in a Southern Chinese Population. ( 26941572 )
2016
3
CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus. ( 26100672 )
2015
4
Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. ( 22350409 )
2012
5
ALK-Related Neuroblastoma Susceptibility ( 20301782 )
1993

Variations for Neuroblastoma, Susceptibility

Expression for Neuroblastoma, Susceptibility

Search GEO for disease gene expression data for Neuroblastoma, Susceptibility.

Pathways for Neuroblastoma, Susceptibility

Pathways related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
10.81 AURKA AURKB
2 10.47 AURKA AURKB
3 10.11 AURKA AURKB

GO Terms for Neuroblastoma, Susceptibility

Cellular components related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 spindle microtubule GO:0005876 9.32 AURKA AURKB
2 spindle midzone GO:0051233 9.26 AURKA AURKB
3 condensed nuclear chromosome, centromeric region GO:0000780 9.16 AURKA AURKB
4 spindle pole centrosome GO:0031616 8.96 AURKA AURKB
5 chromosome passenger complex GO:0032133 8.62 AURKA AURKB

Biological processes related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein autophosphorylation GO:0046777 9.33 ALK AURKA AURKB
2 spindle organization GO:0007051 8.96 AURKA AURKB
3 regulation of signal transduction by p53 class mediator GO:1901796 8.8 AURKA AURKB BARD1

Molecular functions related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein serine/threonine/tyrosine kinase activity GO:0004712 8.96 AURKA AURKB
2 histone serine kinase activity GO:0035174 8.62 AURKA AURKB

Sources for Neuroblastoma, Susceptibility

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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