MCID: NRB002
MIFTS: 27

Neuroblastoma, Susceptibility malady

Categories: Genetic diseases (common), Neuronal diseases

Aliases & Classifications for Neuroblastoma, Susceptibility

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Aliases & Descriptions for Neuroblastoma, Susceptibility:

Name: Neuroblastoma, Susceptibility 22

Classifications:



Summaries for Neuroblastoma, Susceptibility

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MalaCards based summary: Neuroblastoma, Susceptibility is related to neuroblastoma and alk-related neuroblastoma susceptibility. An important gene associated with Neuroblastoma, Susceptibility is PHOX2B (Paired Like Homeobox 2b), and among its related pathways are Cell cycle_Role of APC in cell cycle regulation and Aurora B signaling. Affiliated tissues include bone, bone marrow and kidney.

Related Diseases for Neuroblastoma, Susceptibility

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Graphical network of diseases related to Neuroblastoma, Susceptibility:



Diseases related to neuroblastoma, susceptibility

Symptoms for Neuroblastoma, Susceptibility

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Drugs & Therapeutics for Neuroblastoma, Susceptibility

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Drugs for Neuroblastoma, Susceptibility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Adjuvants, ImmunologicPhase 31783
2lenograstimPhase 31134
3Immunologic FactorsPhase 318483
4
CefpodoximeapprovedPhase 1882619-04-36335986
Synonyms:
(6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(methyloxy)imino]acetyl}amino)-3-[(methyloxy)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
7-{[(2-amino-1,3-thiazol-4-yl)(methoxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
80210-62-4
AC1O3S8J
AC1O426G
AC1Q6LP9
BIDD:GT0771
C08114
C15H17N5O6S2
CEFPODOXIME
CHEBI:606443
CHEMBL1672
CID6335986
CID9570848
CPDX
 
CPDX-PR
Cefpodoxim acid
Cefpodoxima
Cefpodoxima [Spanish]
Cefpodoxime (INN)
Cefpodoxime [INN:BAN]
Cefpodoxime proxetil
Cefpodoximum
Cefpodoximum [Latin]
D07650
DB01416
Epoxim
Epoxim (TN)
LS-177540
MolPort-003-845-691
RU 51807
TL8005407
UNII-7R4F94TVGY
Vantin
5
Irinotecanapproved, investigationalPhase 1104497682-44-5, 100286-90-660838
Synonyms:
(+)-Irinotecan
(4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE
(4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-9-yl 4-piperidylpiperidinecarboxylate
1u65
97682-44-5
AC-7469
AC1L1U0Z
AC1Q6PGI
BRD-K08547377-003-02-4
BSPBio_002346
Bio-0054
Biotecan
Biotecan (TN)
C16641
C33H38N4O6
CHEBI:105985
CHEMBL481
CID60838
CP0
Campothecin-11
Campto
Camptosar
 
Camptosar, Campto, CPT-11, Irinotecan
Camptothecin-11
D08086
DB00762
FT-0083650
HSDB 7607
IRINOTECAN HYDROCHLORIDE Trihydrate
IRINOTECAN, CPT-11
Irinotecan
Irinotecan (INN)
Irinotecan Hcl
Irinotecan Hydrochloride
Irinotecan Hydrochloride Trihydrate
Irinotecan [INN:BAN]
Irinotecan hydrochloride
Irinotecanum
Irinotecanum [INN-Latin]
LS-44589
NCI60_005051
NSC728073
S1198_Selleck
TL8006026
UNII-7673326042
irinotecan
6
CefiximeapprovedPhase 12079350-37-154362, 5362065
Synonyms:
(-)-Cefixim
(6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl}amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-7-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(carboxymethyloxyimino)acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(carboxymethyl)oxy]imino}acetyl]amino}-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6r,7r)-7-[-2-(2-amino-thiazol-4-yl)-2-carboxymethoxyimino-acetylamino]-8-oxo-3-vinyl-5-thia-1-aza-b
79350-37-1
7beta-{(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido}-3-ethenyl-3,4-didehydrocepham-4-carboxylic acid
AB00513842
AC-4350
AC1NSFNI
BPBio1_000622
BRD-K71059170-001-02-5
BSPBio_000564
C06881
CEFIXIME
CFIX
CHEBI:472657
CHEBI:530642
CHEMBL1541
CID5362065
CL-284635
 
Cefixim
Cefixima
Cefixima [Spanish]
Cefixime (JP15/USP/INN)
Cefixime Anhydrous
Cefiximum
Cefiximum [Latin]
Céfixime
D00258
Denvar
FK-027
FR-17027
LS-187248
MLS002222332
MolPort-003-845-687
NCGC00179521-01
Necopen
Prestwick3_000462
SMR001307271
Suprax
Suprax (TN)
Tricef
7
Bortezomibapproved, investigational, experimentalPhase 1769179324-69-7387447, 93860
Synonyms:
179324-69-7
AC1L8TUW
Bortezomib
Bortezomib (JAN/USAN/INN)
CHEBI:287372
CHEBI:41143
CHEMBL325041
CID387447
D03150
DB07475
DPBA
FT-0082488
I14-3268
LDP-341
LDP341
LPD 341
LPD-341
 
MLN341
MolPort-003-845-298
N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE
N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide
NCI60_029010
NSC-681239
NSC681239
PROSCRIPT BORONIC ACID
PS 341
PS-341
Pyz-Phe-boroLeu
S1013_Selleck
SBB071337
Velcade
Velcade (TN)
Velcade, MG-341, PS-341, Bortezomib
[(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
bortezomib
8Topoisomerase InhibitorsPhase 14081
9topoisomerase I inhibitorsPhase 11131
10Antineoplastic Agents, PhytogenicPhase 14294
11Cefpodoxime proxetilPhase 18

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With CancerRecruitingNCT01987596Phase 3
2Study of Irinotecan and Bortezomib in Children With Recurrent/Refractory NeuroblastomaActive, not recruitingNCT00644696Phase 1
3Genetic Susceptibility and Risk of Second Cancers in Patients Who Have Undergone Stem Cell Transplant for CancerRecruitingNCT00949052
4Genetic Biomarkers in Children With Neuroblastoma (Also Known as Neuroblastoma Epidemiology in North America [NENA])Active, not recruitingNCT01119560
5Genetic Analysis Using Blood or Bone Marrow From Participants With Neuroblastoma or Noncancerous ConditionsActive, not recruitingNCT00436696
6Genomic Structural Variation in Cancer SusceptibilityEnrolling by invitationNCT00996710

Search NIH Clinical Center for Neuroblastoma, Susceptibility

Genetic Tests for Neuroblastoma, Susceptibility

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Genetic tests related to Neuroblastoma, Susceptibility:

id Genetic test Affiliating Genes
1 Neuroblastoma, Susceptibility22 PHOX2B

Anatomical Context for Neuroblastoma, Susceptibility

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MalaCards organs/tissues related to Neuroblastoma, Susceptibility:

33
Bone, Bone marrow, Kidney

Animal Models for Neuroblastoma, Susceptibility or affiliated genes

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MGI Mouse Phenotypes related to Neuroblastoma, Susceptibility:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Neuroblastoma, Susceptibility

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Articles related to Neuroblastoma, Susceptibility:

idTitleAuthorsYear
1
CASC15-S Is a Tumor Suppressor lncRNA at the 6p22 Neuroblastoma Susceptibility Locus. (26100672)
2015
2
Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. (22350409)
2012
3
ALK-Related Neuroblastoma Susceptibility (20301782)
1993

Variations for Neuroblastoma, Susceptibility

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Expression for genes affiliated with Neuroblastoma, Susceptibility

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Search GEO for disease gene expression data for Neuroblastoma, Susceptibility.

Pathways for genes affiliated with Neuroblastoma, Susceptibility

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Pathways related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.7AURKA, AURKB
2
Show member pathways
9.7AURKA, AURKB
39.7AURKA, AURKB
49.7AURKA, AURKB

GO Terms for genes affiliated with Neuroblastoma, Susceptibility

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Cellular components related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1spindle microtubuleGO:00058769.7AURKA, AURKB

Biological processes related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1spindle organizationGO:00070519.7AURKA, AURKB

Sources for Neuroblastoma, Susceptibility

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet