MCID: NRB002
MIFTS: 22

Neuroblastoma, Susceptibility malady

Genetic diseases (common), Neuronal diseases categories

Aliases & Classifications for Neuroblastoma, Susceptibility

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Neuroblastoma, Susceptibility, Aliases & Descriptions:

Name: Neuroblastoma, Susceptibility 20


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Neuronal diseases


Summaries for Neuroblastoma, Susceptibility

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MalaCards based summary: Neuroblastoma, Susceptibility is related to neuroblastoma and alk-related neuroblastoma susceptibility. An important gene associated with Neuroblastoma, Susceptibility is PHOX2B (paired-like homeobox 2b), and among its related pathways are Cell cycle Spindle assembly and chromosome separation and Cell cycle Role of APC in cell cycle regulation. The compounds sns 314 mesylate and cct 137690 have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and embryogenesis.

Related Diseases for Neuroblastoma, Susceptibility

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Graphical network of diseases related to Neuroblastoma, Susceptibility:



Diseases related to neuroblastoma, susceptibility

Symptoms for Neuroblastoma, Susceptibility

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Drugs & Therapeutics for Neuroblastoma, Susceptibility

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Drug clinical trials:

Search ClinicalTrials for Neuroblastoma, Susceptibility

Search NIH Clinical Center for Neuroblastoma, Susceptibility

Genetic Tests for Neuroblastoma, Susceptibility

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Genetic tests related to Neuroblastoma, Susceptibility:

id Genetic test Affiliating Genes
1 Neuroblastoma, Susceptibility20 PHOX2B

Anatomical Context for Neuroblastoma, Susceptibility

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Animal Models for Neuroblastoma, Susceptibility or affiliated genes

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MGI Mouse Phenotypes related to Neuroblastoma, Susceptibility:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.4AURKA, AURKB, BARD1, NME1
2MP:00053808.3PHOX2B, NME1, BARD1, AURKB, AURKA
3MP:00107688.1PHOX2B, NME1, BARD1, KIF1B, AURKB, AURKA

Publications for Neuroblastoma, Susceptibility

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Articles related to Neuroblastoma, Susceptibility:

idTitleAuthorsYear
1
Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. (22350409)
2012
2
ALK-Related Neuroblastoma Susceptibility (20301782)
1993

Variations for Neuroblastoma, Susceptibility

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Expression for genes affiliated with Neuroblastoma, Susceptibility

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Search GEO for disease gene expression data for Neuroblastoma, Susceptibility.

Pathways for genes affiliated with Neuroblastoma, Susceptibility

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Pathways related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6AURKB, AURKA
29.6AURKB, AURKA
3
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.6AURKA, AURKB
49.6AURKB, AURKA
59.6AURKB, AURKA

Compounds for genes affiliated with Neuroblastoma, Susceptibility

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Sources:
59Tocris Bioscience, 43Novoseek, 28IUPHAR, 24HMDB, 12DrugBank
See all sources

Compounds related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1sns 314 mesylate599.8AURKB, AURKA
2cct 137690599.8AURKA, AURKB
3tc-a 2317 hydrochloride599.8AURKA, AURKB
4anacardic acid599.7AURKA, AURKB
5hesperadin hydrochloride599.7AURKA, AURKB
617-(allylamino)-17-demethoxygeldanamycin439.5NME1, ALK
7aspartate439.3NME1, ALK, AURKA
8adp43 28 2410.9AURKA, AURKB, ALK, NME1
9Adenosine triphosphate24 129.8AURKA, AURKB, ALK, NME1

GO Terms for genes affiliated with Neuroblastoma, Susceptibility

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Biological processes related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1spindle stabilizationGO:00431469.6AURKB, AURKA
2anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic processGO:00311459.6AURKB, AURKA
3negative regulation of protein bindingGO:00320919.3AURKB, AURKA
4protein autophosphorylationGO:00467779.2ALK, AURKB, AURKA

Molecular functions related to Neuroblastoma, Susceptibility according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1RNA polymerase II regulatory region sequence-specific DNA bindingGO:00009779.8PHOX2B, NME1
2protein serine/threonine/tyrosine kinase activityGO:00047129.3AURKB, AURKA
3ATP bindingGO:00055248.5NME1, KIF1B, ALK, AURKB, AURKA

Products for genes affiliated with Neuroblastoma, Susceptibility

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Neuroblastoma, Susceptibility

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet