Neurodegeneration malady

Wikipedia: Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons,...⁴⁴ more...

MalaCards: Neurodegeneration, also known as nerve degeneration, is related to neuronitis and neurodegenerative disease. An important gene associated with Neurodegeneration is PANK2 (pantothenate kinase 2), and among its related pathways are Neuroscience and Alzheimers disease. The compounds calcium and atp have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cortex, and related mouse phenotypes are behavior/neurological and mortality/aging.

neurodegeneration 7 32 nerve degeneration 43

Diseases related to neurodegeneration by text searches and GeneDecks gene sharing:

(show top 50)    (show all 847)

id	Related Disease	Score	Top Affiliating Genes
1	neuronitis	66.4	ZNF746, ZNF259, PIK3CB, PINK1, PIK3CG, PIN1
2	neurodegenerative disease	58.6	PINK1, PIK3CG, PIN1, LRP1, RELN, CNR1
3	dementia	47.2	PINK1, PIK3CG, PIN1, LRP1, RELN, SERPINI1
4	cerebritis	46.3	PIK3CG, LRP1, LRP2, RELN, SGK1, CNR1
5	ischemia	45.6	PIK3CG, SGK1, CNR1, CNR2, CNTF, SETD2
6	ataxia	44.3	PIK3CG, PIN1, LRP1, LRP2, CNR2, NBN
7	lateral sclerosis	44.0	ZNF746, CNR1, CNR2, CNTF, SERPINE2, SETD2
8	amyotrophic lateral sclerosis	43.6	ZNF746, CNR1, CNR2, CNTF, SERPINE2, SETD2
9	retinitis	43.3	PIK3CG, LRP1, LRP2, SGK1, CNR1, CNR2
10	huntington's disease	41.3	CNR1, CNTF, VPS13A, SETD2, SERPINI1, SERPINA3
11	hypoxia	40.1	PIK3CB, PIK3CG, LRP1, WARS, KIF16B, RBX1
12	cholesterol	39.5	ZNF259, PIK3CB, PIK3CG, PIK3C3, LRP1, LRP2
13	neuropathy	39.4	CNR1, CNTF, VPS13A, SERPINF1, VIP, BSCL2
14	multiple sclerosis	37.6	PINK1, LRP1, RELN, CNR1, CNR2, CNTF
15	alzheimer's disease	36.7	CLU, ITM2B, APOE, APP, MAPT, IDE
16	hallervorden-spatz syndrome	36.6	PANK2, FTL, FA2H, SNCG, SNCB, SNCA
17	parkinson's disease	36.6	PARK7, UCHL1, MAPT, TBP, SNCA, ADPRH
18	tauopathy	35.0	SERPINI1, PARK7, PARK2, CDK5, CDKN3, INA
19	tremor	34.7	PINK1, CNR1, PARK7, PARK2, PANK2, UCHL1
20	multiple system atrophy	34.3	SERPINA3, PARK7, PARK2, BDNF, CHAT, UCHL1
21	encephalitis	34.0	PIK3CG, CNR1, CNR2, CNTF, VEGFA, BMP6
22	gliosis	33.9	PIK3C3, CNTF, GCDH, PARK2, CHAT, BACE1
23	cervicitis	33.6	PIK3CG, PIN1, NCL, CNR1, WARS, SETD2
24	spinocerebellar ataxia type 3	33.4	VCP, BLZF1, BECN1, PARK2, CHERP, UBC
25	paralysis	32.8	CNTF, NAIP, VCP, PARK2, BCHE, CHKA
26	alcoholism	32.7	CNR1, ARSA, GSR, GRIN1, GRIN2A, GRIN2B
27	down syndrome	32.7	NCL, CNR1, CNR2, RCAN1, SERPINA3, VIP
28	motor neuron disease	32.5	CNTF, BSCL2, NAIP, VEGFA, VCP, LIF
29	supranuclear palsy	32.2	VEGFA, PARK7, PARK2, BCHE, CHAT, CDK5
30	obesity	31.7	PIK3CB, PIK3CG, LRP1, SGK1, CNR1, CNR2
31	progressive supranuclear palsy	31.2	PARK7, PARK2, CHAT, CDK5, APOE, APP
32	temporal lobe epilepsy	31.2	RELN, BDNF, GRIN1, GRIN2B, GRM1, APOA1
33	lysosomal storage disease	30.9	CLN3, GUSB, ARSH, ARSA, TPP1, SUMF1
34	friedreich ataxia	30.8	PANK2, SACS, ATXN3, ATXN2, ATXN1, FXN
35	cataract	30.7	SERPINF1, VEGFA, BMP6, RAB18, BLZF1, PARP1
36	immunodeficiency	30.4	VIP, BMP6, BLZF1, PARP1, PARK2, CIITA
37	diabetic neuropathy	30.3	CNTF, INS, TRPV1, NTF3, NTRK1, NGF
38	encephalomyelitis	30.2	CNR1, CNTF, VIP, VEGFA, BMP6, PARK7
39	ceroid lipofuscinosis	30.1	SERPINA3, CLN3, CLN8, ATP13A2, APP, CAPN5
40	neuronal ceroid-lipofuscinosis	30.0	SERPINA3, CLN3, CLN8, ATP13A2, APP, CAPN5
41	spinocerebellar ataxia type 7	29.8	CHERP, ATXN3, ATXN2, ATXN1, ATN1, ATXN7
42	polyneuropathy	29.7	CNTF, VEGFA, BMP6, LIF, BLVRB, CLU
43	alcohol abuse	29.6	BRAF, AVP, CETP, MMP9, GSR, GSS
44	neuronal ceroid-lipofuscinoses	29.5	CLN3, CLN8, CALB2, TPP1, CTSD, PPT1
45	carcinoma	29.3	PIK3CB, PIK3CG, PIN1, PIK3C3, LRP1, LRP2
46	neuroaxonal dystrophy	29.2	PANK1, PANK2, APP, IGF1, NTF3, NTRK1
47	ataxia telangiectasia	29.1	PIK3CG, NBN, PARP1, BCL2, CHEK1, CHEK2
48	xeroderma pigmentosum	28.6	RBX1, PARP1, BCL2, UBC, BAX, ATM
49	brain edema	28.4	SERPINE2, VEGFA, PARP1, MMP9, IL1B, IL1RN
50	migraine without aura	28.1	LDLR, S100B, GSTP1, ENO2, CCL2, CACNA1A

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to neurodegeneration:

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MGI Mouse Phenotypes related to neurodegeneration:

²⁵ (show all 30)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	25.4	PINK1, PIK3C3, LRP1, LRP2, NCSTN, RELN
2	mortality/aging	MP:0010768	24.0	ZNF259, PIK3CB, PIK3C3, LRP1, NCSTN, RELN
3	homeostasis/metabolism phenotype	MP:0005376	22.5	PIK3CB, PINK1, PIK3CG, PIK3C3, LRP1, LRP2
4	nervous system phenotype	MP:0003631	22.3	LRP1, NCSTN, RELN, CNR1, CNTF, VPS13A
5	growth/size phenotype	MP:0005378	21.4	PIK3CB, PINK1, PIK3CG, PIN1, PIK3C3, LRP1
6	cellular phenotype	MP:0005384	20.8	ZNF259, PIK3CB, PINK1, PIK3CG, PIN1, PIK3C3
7	immune system phenotype	MP:0005387	16.8	PINK1, PIK3C3, LRP1, NCSTN, CNR2, CNTF
8	integument phenotype	MP:0010771	15.5	PIK3CG, PIN1, RELN, CNR1, CNR2, BSCL2
9	embryogenesis phenotype	MP:0005380	14.2	ZNF259, PIK3CB, PIK3C3, NCSTN, KIF16B, RBX1
10	hematopoietic system phenotype	MP:0005397	14.1	CNTF, RCAN1, VPS13A, NBN, SEPT5, BSCL2
11	reproductive system phenotype	MP:0005389	13.9	RCAN1, NBN, SERPINE2, SERPINF1, VIP, VEGFA
12	respiratory system phenotype	MP:0005388	13.9	LRP2, LIF, CLCN7, PARK2, BDNF, CHRNA7
13	normal phenotype	MP:0002873	13.8	PIK3C3, LRP1, NCSTN, VIP, NAIP, BRAF
14	no phenotypic analysis	MP:0003012	13.8	PINK1, LRP2, SGK1, CNR1, SERPINE2, BSCL2
15	renal/urinary system phenotype	MP:0005367	13.5	LRP2, SGK1, GCDH, BSCL2, BRAF, CLU
16	cardiovascular system phenotype	MP:0005385	13.1	PIK3CB, PIK3CG, PIK3C3, LRP1, NCSTN, RCAN1
17	endocrine/exocrine gland phenotype	MP:0005379	12.8	PINK1, LRP2, RCAN1, NBN, SERPINE2, PARG
18	muscle phenotype	MP:0005369	12.5	PIK3CG, PIK3C3, LRP1, RELN, CNTF, BRAF
19	craniofacial phenotype	MP:0005382	12.4	LRP2, NCSTN, NBN, CLCN7, BDNF, LAMP2
20	vision/eye phenotype	MP:0005391	12.4	PIN1, LRP2, NCSTN, RELN, SERPINF1, BRAF
21	other phenotype	MP:0005395	12.3	CNR1, CLU, LDLR, BACE1, MME, APOE
22	liver/biliary system phenotype	MP:0005370	11.7	PIK3C3, BSCL2, VEGFA, LIF, CLN3, PANK1
23	hearing/vestibular/ear phenotype	MP:0005377	11.6	LRP2, PARP1, BDNF, BCL2, BAX, P2RX7
24	taste/olfaction phenotype	MP:0005394	11.4	CNR1, BDNF, ENO2, MAPT, MAPK1, HTT
25	digestive/alimentary phenotype	MP:0005381	11.1	LRP2, RELN, SERPINF1, BSCL2, BRAF, VEGFA
26	skeleton phenotype	MP:0005390	10.8	PIK3CG, LRP1, LRP2, CNR1, BTG2, BRAF
27	adipose tissue phenotype	MP:0005375	10.6	LRP1, CNR1, BSCL2, BRAF, LIF, BCL2
28	pigmentation phenotype	MP:0001186	10.4	SERPINF1, BRAF, VAC14, CLCN7, CLN8, BCL2
29	limbs/digits/tail phenotype	MP:0005371	10.2	VEGFA, CLCN7, UCHL1, BAX, P2RX7, ATF2
30	tumorigenesis	MP:0002006	9.8	PIK3CB, NCSTN, RCAN1, NBN, BRAF, BECN1

Articles related to neurodegeneration:

(show top 50)    (show all 586)

id	Title	Authors	Year	Affiliating Genes
1	HDAC inhibitors and neurodegeneration: at the edge be tween protection and damage. (20123018)	Dietz K.C.... Casaccia P.	2010	HDAC9
2	Conditional inactivation of the NBS1 gene in the mous e central nervous system leads to neurodegeneration and disorganization of the visual system. (19345213)	Baranes K.... Solomon A.S.	2009	NBN
3	Could PKR inhibition modulate human neurodegeneration ? (19831834)	Hugon J.... Chang R.C.	2009	EIF2AK2
4	Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration. (19279216)	Moore J.K.... Cooper J.A.	2009	DCTN1
5	Tau oligomerization: a role for tau aggregation intermediates linked to neurodegeneration. (19075586)	Sahara N.... Takashima A.	2008	MAPT
6	Anticholinergic-responsive gait freezing in a patient with pantothenate kinase-associated neurodegeneration. (17999425)	Lyoo C.H.... Lee M.S.	2008	PANK2
7	Tumorigenesis and neurodegeneration: two sides of the same coin? (18623069)	Staropoli J.F.	2008	PARK2
8	Autophagy in neurodegeneration and development. (18644437)	Winslow A.R.... Rubinsztein D.C.	2008	HTT
9	Vasoactive intestinal peptide protects against beta-amyloid-induced neurodegeneration by inhibiting microglia activation at multiple levels. (18442091)	Delgado M.... Gonzalez-Rey E.	2008	VIP
10	Scyl1, mutated in a recessive form of spinocerebellar neurodegeneration, regulates COPI-mediated retrograde traffic. (18556652)	Burman J.L.... McPherson P.S.	2008	COPB1, SCYL1
11	Polyglutamine domain modulates the TBP-TFIIB interaction: implications for its normal function and neurodegeneration. (17994014)	Friedman M.J.... Li X.J.	2007	TBP, GTF2B
12	Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection. (17371291)	Hennigan A.... Kelly A.M.	2007	NGFR
13	Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein. (17600340)	Zhang W.... Zhang J.	2007	SNCA
14	Neurodegeneration caused by expression of human truncated tau leads to progressive neurobehavioural impairment in transgenic rats. (17169350)	Hrnkova M.... Novak M.	2007	MAPT
15	Nicotine induces tyrosine hydroxylase plasticity in the neurodegenerating striatum. (17437548)	Urbanavicius J.... Dajas F.	2007	TH, DDC
16	Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis. (17314303)	Shacka J.J.... Roth K.A.	2007	CTSD, CASP3, BAX
17	New insights into the roles of metalloproteinases in neurodegeneration and neuroprotection. (17678958)	Turner A.J.... Nalivaeva N.N.	2007	APP
18	Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. (16901708)	Ferrari C.C.... Pitossi F.J.	2006	IL1B
19	Gene expression profiling in frataxin deficient mice: microarray evidence for significant expression changes without detectable neurodegeneration. (16442805)	Coppola G.... Geschwind D.H.	2006	FXN
20	Gene symbol: PANK2. Disease: pantothenate kinase-associated neurodegeneration (PKAN). (17128479)	Westaway S.K.... Hayflick S.J.	2006	PANK2
21	Role of melatonin in Alzheimer-like neurodegeneration. (16364209)	Wang J.Z.... Wang Z.F.	2006	MAPT
22	Molecular mechanisms of nigral neurodegeneration in Park2 and regulation of parkin protein by other proteins. (17017530)	Hattori N.... Mizuno Y.	2006	PARK2
23	Gene symbol: PANK2. Disease: pantothenate kinase-associated neurodegeneration (PKAN). (17128481)	Westaway S.K.... Richards S.	2006	PANK2
24	Prostaglandin-induced neurodegeneration is associated with increased levels of oxidative markers and reduced by a mixture of antioxidants. (15920743)	Yan X.D.... Prasad K.N.	2005	HMOX1, GPX1
25	Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. (16269331)	Chandra S.... Sudhof T.C.	2005	SNCA
26	Gene symbol: PANK2. Disease: Pantothenate kinase associated neurodegeneration (PKAN). (15991335)	Wieczorek S.W.... Epplen J.T.	2005	PANK2
27	Neurodegeneration caused by ER stress?--the pathogenetic mechanisms underlying AR-JP (15572841)	Takahashi R.	2004	PARK2, GPR37
28	Identification of post-mortem cerebrospinal fluid proteins as potential biomarkers of ischemia and neurodegeneration. (15274117)	Lescuyer P.... Hochstrasser D.F.	2004	FABP3, FABP5
29	U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy. (15447663)	Hatakeyama S.... Takashima A.	2004	MAPT, UBC, STUB1
30	HIV associated neurodegeneration requires p53 in neurons and microglia. (15155568)	Garden G.A.... Morrison R.S.	2004	TP53
31	Mixed-lineage kinases: a target for the prevention of neurodegeneration. (14744254)	Wang L.H.... Johnson E.M.	2004	MAPK8, MAP3K13
32	Tourettism, hemiballism and juvenile Parkinsonism: e xpanding the clinical spectrum of the neurodegeneration associated to pantothen ate kinase deficiency (Hallervorden Spatz syndrome) (14997456)	Carod-Artal F.J.... Portugal D.	2004	HEXA
33	Clinical heterogeneity of neurodegeneration with brain iron accumulation (Hallervorden-Spatz syndrome) and pantothenate kinase-associated neurodegeneration. (14743358)	Thomas M.... Jankovic J.	2004	PANK2
34	Modulation of microtubule dynamics by tau in living cells: implications for development and neurodegeneration. (15020716)	Bunker J.M.... Feinstein S.C.	2004	MAPT
35	Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer's and Parkinson's diseases. (14528050)	Hashimoto M.... Masliah E.	2003	SNCA, CYCS
36	Regulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease. (12180271)	Alvarez G.... DA-az-Nido J.	2002	APP, MAPT
37	Caspase cascades in human immunodeficiency virus-associated neurodegeneration. (12019321)	Garden G.A.... Lipton S.A.	2002	CASP3, CYCS
38	Biological data and clinical symptoms as predictors of astrogliosis and neurodegeneration in patients with second-stage Trypanosoma brucei gambiense sleeping sickness. (11792001)	Lejon V.... BA1scher P.	2001	GFAP
39	Dysfunctional intracellular calcium homoeostasis: a c entral cause of neurodegeneration in Alzheimer's disease. (11447834)	O'Neill C.... Kelliher M.	2001	MAPT
40	Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. (10841577)	Capsoni S.... Cattaneo A.	2000	NGF
41	Aberrant expression of nitric oxide synthase III in Alzheimer's disease: relevance to cerebral vasculopathy and neurodegeneration. (10867216)	de la Monte S.M.... Wands J.R.	2000	NOS3
42	The alpha-ketoglutarate dehydrogenase complex in neurodegeneration. (10676873)	Gibson G.E.... Calingasan N.Y.	2000	DLST
43	Molecular misreading of genes in Down syndrome as a model for the Alzheimer type of neurodegeneration. (10666673)	van Leeuwen F.W.... Hol E.M.	1999	UBB
44	Neurodegeneration in hereditary nucleotide repair dis orders. (10413020)	Itoh M.... Oda M.	1999	RPS27A
45	Identification of 167 polymorphisms in 88 genes from candidate neurodegeneration pathways. (10570959)	Emahazion T.... Brookes J.A.	1999	NDUFB8
46	Effects of different schedules of MPTP administration on dopaminergic neurodegeneration in mice. (9398471)	Bezard E.... Gross C.	1997	TH
47	The GluR2 hypothesis: Ca(++)-permeable AMPA receptors in delayed neurodegeneration. (9246466)	Bennett M.V.... Zukin R.S.	1996	GRIA2
48	Expanded glutamines and neurodegeneration--a gain of insight. (8867730)	Bates G.	1996	HTT
49	Inflammation, A beta deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration. (8858005)	Lue L.F.... Rogers J.	1996	APP
50	Tau protein and neurodegeneration. (2135393)	Kosik K.S.	1990	MAPT

Genes related to neurodegeneration according to GeneCards:

(show top 50)    (show all 512)

id	Symbol	Description	Score	GeneCards Section Context
1	PANK2	pantothenate kinase 2	11.1	Summaries, Publications, Aliases & Descriptions
2	C19orf12	chromosome 19 open reading frame 12	11.0	Publications, Summaries
3	ADAM8	ADAM metallopeptidase domain 8	11.0	Summaries, Publications
4	FOLR1	folate receptor 1 (adult)	11.0	Summaries
5	ALDH18A1	aldehyde dehydrogenase 18 family, member A1	11.0	Publications, Summaries
6	MAPK8	mitogen-activated protein kinase 8	11.0	Summaries, Publications
7	DST	dystonin	11.0	Summaries
8	MAPK1	mitogen-activated protein kinase 1	11.0	Publications, Summaries
9	MAPK14	mitogen-activated protein kinase 14	11.0	Summaries
10	PNPLA6	patatin-like phospholipase domain containing 6	11.0	Summaries, Publications
11	BECN1	beclin 1, autophagy related	11.0	Publications, Summaries
12	SPTBN2	spectrin, beta, non-erythrocytic 2	11.0	Publications, Summaries
13	SNCAIP	synuclein, alpha interacting protein	11.0	Summaries, Publications
14	MAPK10	mitogen-activated protein kinase 10	11.0	Publications, Summaries
15	MAPK11	mitogen-activated protein kinase 11	11.0	Summaries
16	MAPK9	mitogen-activated protein kinase 9	11.0	Summaries
17	MAPK3	mitogen-activated protein kinase 3	11.0	Summaries
18	SEPT7P2	septin 7 pseudogene 2	11.0	Summaries
19	NUDT1	nudix (nucleoside diphosphate linked moiety X)-type motif 1	11.0	Summaries
20	FTL	ferritin, light polypeptide	11.0	Publications
21	SNCB	synuclein, beta	11.0	Publications
22	SNCG	synuclein, gamma (breast cancer-specific protein 1)	11.0	Publications
23	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.0	Publications
24	PLA2G6	phospholipase A2, group VI (cytosolic, calcium-independent)	11.0	Publications
25	CDK5R2	cyclin-dependent kinase 5, regulatory subunit 2 (p39)	10.9
26	GPR37	G protein-coupled receptor 37 (endothelin receptor type B-like)	10.9	Publications
27	LYVE1	lymphatic vessel endothelial hyaluronan receptor 1	10.9	Publications
28	MAPT	microtubule-associated protein tau	10.9	Publications
29	NDUFA1	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa	10.9
30	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	10.9	Publications
31	ITM2B	integral membrane protein 2B	10.9	Publications
32	ISG15	ISG15 ubiquitin-like modifier	10.9	Publications
33	CDK5	cyclin-dependent kinase 5	10.9	Functions, Publications
34	PPT1	palmitoyl-protein thioesterase 1	10.9	Publications
35	BSCL2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	10.9
36	FA2H	fatty acid 2-hydroxylase	10.9	Publications
37	PARK7	parkinson protein 7	10.9	Publications
38	NEFH	neurofilament, heavy polypeptide	10.9	Publications
39	RPS27A	ribosomal protein S27a	10.9	Publications
40	NRTN	neurturin	10.9
41	PDIA2	protein disulfide isomerase family A, member 2	10.9	Publications
42	ATXN3	ataxin 3	10.9	Publications
43	CLN8	ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)	10.9
44	TTPA	tocopherol (alpha) transfer protein	10.9	Publications
45	TPI1	triosephosphate isomerase 1	10.9	Publications
46	TPP1	tripeptidyl peptidase I	10.9	Publications
47	GRN	granulin	10.9	Publications
48	ATN1	atrophin 1	10.9	Publications
49	UCHL1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	10.9	Publications
50	HEXA	hexosaminidase A (alpha polypeptide)	10.9	Publications

Pathways related to neurodegeneration according to GeneDecks:

(show top 50)    (show all 253)

id	Pathway	Score	Top Affiliating Genes
1	Neuroscience3	15.7	PINK1, NCSTN, PARK7, PARK2, BACE1, SAG
2	Alzheimers disease20	12.9	LRP1, NCSTN, BACE1, ATF6, CDK5, CDK5R1
3	Neurotrophin signaling pathway20	12.7	PIK3CB, PIK3CG, BRAF, RAF1, BDNF, YWHAE
4	Lysosome20	12.6	CLN3, LAMP2, ATP6V0A4, ATP6V0A2, ATP6V0A1, ATP6V0C
5	Apoptosis and Autophagy3	12.5	PIK3C3, PDCD6IP, BECN1, PAWR, PARP1, BCL2
6	TNF-Induced Apoptosis Implicating Sphingolipids36	12.0	RAF1, BAX, MAPK8, MAPK13, MAPK3, MAPK14
7	Huntingtons disease20	12.0	BDNF, BAX, ITPR1, GRIN1, GRIN2B, GRM1
8	14-3-3 Induced Apoptosis36	11.8	BCL2, YWHAE, YWHAZ, JUN, IL1B, MAPK8
9	Development Neurotrophin family signaling10	11.8	PIK3CB, BRAF, RAF1, BDNF, BAX, XIAP
10	Development_Neurotrophin family signaling41	11.8	PIK3CB, BRAF, RAF1, BDNF, BAX, XIAP
11	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	11.7	PIK3CB, RAF1, BCL2, BAX, JUN, CDK5
12	Ceramide Pathway36	11.7	RAF1, ATF6, ATF2, JUN, MAPK8, MAPK3
13	Influenza A20	11.7	PIK3CB, PIK3CG, RAF1, CIITA, ATF2, JUN
14	NOD-like receptor signaling pathway20	11.7	NAIP, XIAP, IL18, IL1B, MAPK8, MAPK13
15	Alzheimers Disease Pathway36	11.6	LRP1, CDK5, CDK5R1, INSR, GSK3B, APOE
16	Amyotrophic lateral sclerosis (ALS)20	11.5	BCL2, BCL2L1, BAX, GRIA2, GRIN1, GRIN2A
17	Apoptosis and survival Role of CDK5 in neuronal death and survival10	11.5	BCL2, CDK5, CDK5R1, CASP9, CYCS, NTRK1
18	Endothelin-1 Signaling Pathway36	11.4	BRAF, BMP6, RAF1, INSR, IL10, IL18
19	p53 Signaling36	11.3	BCL2, CHEK1, CHEK2, UBB, UBC, BAX
20	Glucose / Energy Metabolism3	11.3	PIK3C3, SGK1, FTH1, IRS1, INSR, GSK3B
21	Pathogenesis of ALS36	11.2	BCL2, BCL2L1, BAX, GRIA2, GRIA3, GRIN1
22	Development_FGFR signaling pathway41	11.2	PIK3CB, RAF1, UBB, UBC, ATF2, JUN
23	Toxoplasmosis20	11.1	PIK3CB, PIK3CG, BCL2, BCL2L1, CIITA, LDLR
24	Apoptosis20	10.9	PIK3CB, PIK3CG, BCL2, BCL2L1, BAX, XIAP
25	Colorectal cancer20	10.9	PIK3CB, PIK3CG, BRAF, GSK3B, APPL1, MAPK8
26	MAPK signaling pathway20	10.8	BRAF, RAF1, BDNF, ATF2, JUN, FGF2
27	MIF Regulation of Innate Immune Cells36	10.8	BMP6, LIF, BCL2, BAX, JUN, IL10
28	Akt Signaling36	10.7	PIK3CG, RAF1, LIF, CHEK1, CD4, IRS1
29	Signaling Involved in Cardiac Hypertrophy36	10.5	BRAF, RAF1, LIF, ATF6, ATF2, JUN
30	UVC-Induced MAPK Signaling36	10.5	BRAF, RAF1, JUN, MAPK8, MAPK13, MAPK3
31	DHA Signaling36	10.5	SERPINF1, BMP6, BDNF, BCL2, BCL2L1, YWHAE
32	Chagas disease (American trypanosomiasis)20	10.4	PIK3CB, PIK3CG, JUN, IL10, IL1B, MAPK8
33	STAT3 Pathway36	10.3	BRAF, BMP6, RAF1, LIF, BCL2, BAX
34	Tuberculosis20	10.2	PIK3C3, RAF1, BCL2, CIITA, BAX, LAMP2
35	Molecular Mechanisms of Cancer36	10.2	PIK3CG, NCSTN, BMP6, RAF1, LIF, BDNF
36	Development_VEGF signaling via VEGFR2 - generic cascades41	10.1	PIK3CB, VEGFA, RAF1, JUN, ITPR1, GSK3B
37	PEDF Induced Signaling36	10.1	SERPINF1, BRAF, BMP6, RAF1, LIF, BDNF
38	Renin-Angiotensin Pathway36	10.1	BMP6, RAF1, BDNF, ATF2, JUN, ITPR1
39	Estrogen Pathway36	10.0	BRAF, BMP6, RAF1, BDNF, BCL2, JUN
40	p70S6K Signaling36	9.9	BMP6, RAF1, BDNF, YWHAE, YWHAZ, IRS1
41	14-3-3 Induced Intracellular Signaling36	9.9	RAF1, BDNF, YWHAE, YWHAZ, JUN, INSR
42	Antioxidant Action of Vitamin-C36	9.9	BMP6, LIF, BDNF, BCL2, BAX, ATF2
43	PAK Pathway36	9.6	BMP6, LIF, BDNF, BCL2, BAX, CFL1
44	Pathways in cancer20	9.4	PIK3CB, PIK3CG, RBX1, VEGFA, BCL2, BCL2L1
45	Prostate cancer20	9.4	PIK3CB, PIK3CG, BRAF, RAF1, BCL2, AR
46	Rheumatoid arthritis20	9.1	VEGFA, ATP6V1G1, ATP6V1B1, ATP6V0A4, ATP6V1G3, ATP6V1B2
47	p38 Signaling36	9.1	BMP6, LIF, BDNF, BCL2, BAX, ATF2
48	JAK-STAT Pathway36	8.6	RBX1, BMP6, RAF1, BDNF, UBB, UBC
49	p53 Mediated Apoptosis36	8.6	BMP6, BDNF, BCL2, CHEK1, CHEK2, BAX
50	Metabolic pathways20	INF	PIK3C3, GCDH, PANK1, PANK3, PANK2, CHKA

Compounds related to neurodegeneration according to GeneDecks:

(show top 50)    (show all 522)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	24.9	PIN1, LRP1, NCL, PDCD6IP, RELN, SGK1
2	atp32	20.8	PIK3CB, PINK1, NCL, WARS, KIF16B, SETD2
3	cysteine32	19.3	LRP1, SERPINF1, SERPINA3, NAIP, RAF1, LIF
4	hydrogen32 18	16.6	PIN1, CNR2, BDNF, CIITA, UCP2, BACE1
5	glucose32	15.4	CNTF, SETD2, SERPINF1, BRAF, BLVRB, PAWR
6	methionine32	15.1	PINK1, RELN, CNTF, SERPINF1, SERPINA3, LIF
7	sodium32 18	15.6	LRP2, SGK1, BRAF, BLVRB, BLZF1, BDNF
8	cyclic amp32 18	15.1	SGK1, CNR1, CNR2, CNTF, SETD2, BRAF
9	proline32	14.0	PIN1, SETD2, CLU, PARK2, BDNF, CIITA
10	progesterone32 42 9 18 9	17.7	CNTF, SETD2, SERPINA3, BRAF, LIF, CLU
11	ceramide32	13.6	CNR1, RAF1, CLN3, BECN1, PAWR, PARK2
12	rotenone32	13.5	PIK3CG, PARP1, PARK7, PARK2, BCL2, BCL2L1
13	levodopa32 9 9	15.3	PINK1, CNR1, PARK7, BDNF, SAG, CDK5
14	methamphetamine32 9 9	15.2	CNTF, BDNF, CHAT, MAP2, MAOA, MAOB
15	camptothecin32 42 9 9	16.0	PIK3CG, NCL, NBN, SETD2, CLU, PARP1
16	glyceraldehyde 3-phosphate32	13.0	SETD2, BLZF1, CLU, UCHL1, P4HB, ATN1
17	morphine32 9 9	14.8	CNR1, VIP, SAG, CDK5, ITIH4, MME
18	4-hydroxynonenal32 18	13.8	PARP1, CHKA, CHAT, UCP2, BACE1, BAX
19	agarose32	12.6	LIF, BLZF1, CLU, PARP1, BCL2, BCL2L1
20	guanidine hydrochloride32	12.4	CNTF, SERPINA3, P4HB, GSR, APOA1, APOE
21	nadph32 18	13.4	BLVRB, CHAT, UCP2, SAG, P4HB, GRIN2A
22	histidine32	12.3	CIITA, CHEK1, S100B, AVP, MME, FOLH1
23	palmitate32	12.3	LDLR, UCP2, XBP1, CETP, IRS1, APOA1
24	fatty acid32	12.2	LRP1, BRAF, BLZF1, CLU, BCHE, CHKA
25	indomethacin32 9 9	14.2	CNR1, VIP, BMP6, RAF1, BLVRB, BDNF
26	carbohydrates32	12.1	BLZF1, BCHE, CIITA, LDLR, UCP2, CETP
27	ionomycin32	11.9	PIK3CB, SETD2, SERPINA3, IL3, MAP2, MAPK3
28	gf 109203x32 42	12.8	PIK3CB, PIK3CG, VEGFA, RAF1, JUN, CDKN3
29	corticosterone32 18	12.8	CNR1, VIP, LIF, BDNF, MPO, ITIH4
30	mannitol32 9 9	13.5	SGK1, S100B, ATF2, FTH1, CDKN3, IRS1
31	bisindolylmaleimide32	11.5	PIK3CB, RAF1, BDNF, S100B, MAPK3, GNAQ
32	pd 98,05932	11.5	PIK3CG, NCL, CNTF, SETD2, BRAF, BMP6
33	mannose 6-phosphate32 18	12.4	LRP1, BMP6, LIF, CLN3, BACE1, LAMP2
34	carbachol32 9 9	13.3	GRM1, MAPK10, CCK, F2RL1, DRD1, SST
35	polysaccharide32	11.3	SERPINE2, SERPINA3, VCP, BMP6, LIF, CLU
36	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	11.1	PARP1, BCL2, BCL2L1, BAX, S100B, MMP9
37	thymidine32 18	12.0	CNR2, CNTF, VIP, BMP6, RAF1, LIF
38	acth32	10.9	VIP, BDNF, AVP, ITIH4, MME, INS
39	nicotine32 34 9 9	13.7	CRH, PDYN, OXT, SIK2
40	verapamil32 34 9 18 9	14.7	LRP1, VIP, LDLR, INSR, GSTP1, FGF2
41	ribonucleic acid32	10.7	BMP6, LIF, BLZF1, CLU, CIITA, UCP2
42	menadione32 9 18 9	13.6	CDC25C, CDK1, GSR, MAPT, MAPK8, MAPK1
43	prostaglandin f2alpha32	10.4	VIP, RAF1, MAPK3, IGF1R, IGF1, HSPB1
44	rosiglitazone32 9 18 9	13.0	PIK3CG, LRP1, UCP2, JUN, MMP9, IRS1
45	troglitazone32 42 9 9	12.8	PIK3CG, BMP6, BCL2, LDLR, UCP2, BAX
46	cytochalasin d32 42	10.8	PIK3CG, RAF1, LDLR, CDKN3, MMP9, INSR
47	bleomycin32 9 9	11.8	ATM, CDKN3, GSTP1, FGF2, CCL2, CCL3
48	tamoxifen32 34 9 9	12.5	VEGFA, BMP6, RAF1, CLU, BDNF, BCL2
49	triptolide32	9.1	VEGFA, PARP1, BCL2, BAX, JUN, IL1B
50	docetaxel32 34 9 9	12.0	SETD2, VEGFA, RAF1, CLU, PARP1, BCL2

Cellular components related to neurodegeneration according to GeneDecks:

(show all 27)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	19.7	PIK3CB, PINK1, PIK3CG, PIK3C3, PDCD6IP, CNTF
2	nucleus	GO:005634	19.3	ZNF746, ZNF259, PIK3CB, PIN1, LRP1, NCL
3	cytoplasm	GO:005737	18.9	ZNF746, ZNF259, PIK3CG, PIN1, LRP1, PDCD6IP
4	plasma membrane	GO:005886	16.0	PIK3CG, LRP2, NCSTN, SGK1, CNR1, CNR2
5	mitochondrion	GO:005739	15.8	PINK1, SGK1, GCDH, CLU, CLN3, CLN8
6	Golgi apparatus	GO:005794	14.0	LRP2, NCSTN, CLN3, BECN1, PARK2, SCYL1
7	nucleoplasm	GO:005654	13.7	PIN1, RBX1, NBN, KHSRP, PARP1, CIITA
8	perinuclear region of cytoplasm	GO:048471	13.6	LIMS1, CLU, PARK2, CHERP, YWHAZ, UBQLN1
9	neuronal cell body	GO:043025	13.3	CNTF, SERPINE2, CHAT, UCHL1, S100B, P2RX7
10	endoplasmic reticulum	GO:005783	13.2	LRP2, NCSTN, VCP, VAC14, CLU, CLN3
11	axon	GO:030424	13.0	CNTF, PARK7, CHAT, UCHL1, SACS, CDK5
12	dendrite	GO:030425	12.5	RELN, CNR2, SACS, AVP, CDK5, CDK5R1
13	lysosome	GO:005764	12.1	LRP2, CLN3, LDLR, LAMP2, ATP13A2, MPO
14	melanosome	GO:042470	12.0	NCSTN, PDCD6IP, SERPINF1, YWHAE, YWHAZ, P4HB
15	caveola	GO:005901	11.4	CLN3, IRS1, INSR, MAPK3, MAPK1, F2R
16	extracellular region	GO:005576	11.2	SERPINE2, SERPINI1, SERPINF1, SERPINA3, VIP, VEGFA
17	perikaryon	GO:043204	11.1	CNR2, CDK5, GRIA2, GRIA3, ENO2, MAP1B
18	postsynaptic density	GO:014069	11.1	YWHAZ, CDK5, CDK5R1, ITPR1, GRIA2, GRIA3
19	late endosome	GO:005770	11.0	PIK3C3, CLN3, LDLR, LAMP2, ATP7A, MAPK3
20	endosome membrane	GO:010008	10.9	VAC14, LDLR, UBB, UBC, ATP6V0A4, ATP6V0A2
21	membrane raft	GO:045121	10.8	CLN3, PAG1, P2RX7, CD4, ITPR1, GSK3B
22	terminal button	GO:043195	10.8	P2RX7, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B
23	synapse	GO:045202	10.7	ITSN1, MME, INSR, GRID2, GRIN1, APBB1
24	cell surface	GO:009986	9.9	VEGFA, LDLR, BACE1, P4HB, MPP2, CD59
25	secretory granule	GO:030141	9.7	VEGFA, AVP, ATP7A, MPO, INS, IL1B
26	extracellular space	GO:005615	8.6	LRP2, RELN, CNTF, SERPINF1, VEGFA, BMP6
27	integral to plasma membrane	GO:005887	INF	LRP1, NCSTN, CNR1, CNR2, LDLR, BACE1

Biological processes related to neurodegeneration according to GeneDecks:

(show top 50)    (show all 92)

id	Name	GO ID	Score	Top Affiliating Genes
1	small molecule metabolic process	GO:044281	15.8	PIK3CB, PIK3CG, PIK3C3, LRP2, GCDH, VAC14
2	innate immune response	GO:045087	13.4	PIK3CG, PIN1, PIK3C3, CLU, BCL2, BCL2L1
3	negative regulation of neuron apoptotic process	GO:043524	13.2	CNTF, NAIP, BRAF, CLN3, PARK7, PARK2
4	synaptic transmission	GO:007268	13.2	BRAF, RAF1, CHRNA7, CHAT, ATXN3, CDK5
5	apoptotic process	GO:006915	12.7	NCSTN, PDCD6IP, SGK1, NBN, RAF1, PAWR
6	nerve growth factor receptor signaling pathway	GO:048011	12.1	PIK3CB, NCSTN, BRAF, RAF1, YWHAE, UBB
7	regulation of sequence-specific DNA binding transcription factor activity	GO:051090	12.0	SGK1, ATF2, JUN, MAPK8, MAPK3, MAPK14
8	MyD88-dependent toll-like receptor signaling pathway	GO:002755	12.0	UBB, UBC, ATF2, JUN, CDK1, MAPK8
9	activation of MAPK activity	GO:000187	12.0	PIK3CB, CHRNA7, UBB, UBC, P2RX7, CDK1
10	memory	GO:007613	12.0	CNR1, CHRNA7, CHAT, S100B, GRIN2A, IL1B
11	response to oxidative stress	GO:006979	11.9	ATRN, MPO, MMP9, GSS, MARK2, ALS2
12	nervous system development	GO:007399	11.8	NAIP, VEGFA, CLN8, BDNF, CHERP, ATXN3
13	signal transduction	GO:007165	11.7	ZNF259, PIK3CB, CNTF, RCAN1, VAC14, RAF1
14	cellular iron ion homeostasis	GO:006879	11.7	ATP6V1G1, ATP6V1B1, ATP6V0A4, ATP6V1G3, ATP6V1B2, ATP6V0A2
15	locomotory behavior	GO:007626	11.6	AVP, ATP7A, GRM1, APP, HTT, ALS2
16	response to toxin	GO:009636	11.5	BCL2, BAX, CDK1, MBP, MAOB, CCL3
17	stress-activated MAPK cascade	GO:051403	11.5	UBB, UBC, ATF2, JUN, CDK1, MAPK8
18	adult walking behavior	GO:007628	11.5	CLN8, CHAT, UCHL1, ATG7, FXN, MAPT
19	response to lipopolysaccharide	GO:032496	11.5	CNR1, CNR2, P2RX7, JUN, MMP9, APOB
20	positive regulation of apoptotic process	GO:043065	11.5	CNR1, CLU, PAWR, BAX, P2RX7, ATM
21	response to wounding	GO:009611	11.5	GRIN2A, GRIN2C, CCR2, F2R, CASP3, CTSB
22	interaction with host	GO:051701	11.4	ATP6V1G1, ATP6V1B1, ATP6V0A4, ATP6V1G3, ATP6V1B2, ATP6V0A2
23	phagosome maturation	GO:090382	11.4	ATP6V1G1, ATP6V1B1, ATP6V0A4, ATP6V1G3, ATP6V1B2, ATP6V0A2
24	neuron apoptotic process	GO:051402	11.4	BCL2, BAX, ATM, ATN1, CDK5, APP
25	response to drug	GO:042493	11.4	LRP2, NBN, PARK7, BDNF, BCHE, BCL2
26	induction of apoptosis by extracellular signals	GO:008624	11.3	NCSTN, YWHAE, UBB, UBC, BAX, ITSN1
27	positive regulation of neuron apoptotic process	GO:043525	11.2	BAX, ATM, JUN, CDK5, CDK5R1, IL18
28	transferrin transport	GO:033572	11.0	ATP6V1G1, ATP6V1B1, ATP6V0A4, ATP6V1G3, ATP6V1B2, ATP6V0A2
29	insulin receptor signaling pathway	GO:008286	11.0	PIK3CB, PIK3C3, RAF1, BAIAP2, ATP6V1G1, ATP6V1B1
30	response to glucocorticoid stimulus	GO:051384	11.0	SERPINF1, BCHE, INSR, IL10, IL1B, IL1RN
31	aging	GO:007568	11.0	LRP2, CNR1, SERPINF1, JUN, IL1B, CCL2
32	response to ethanol	GO:045471	10.8	CNR1, BCL2, CHAT, AVP, CDK1, MMP9
33	response to heat	GO:009408	10.8	BCL2, MMP9, IRF1, IL1B, CCL2, HSPA4
34	anti-apoptosis	GO:006916	10.8	NAIP, BRAF, BECN1, BDNF, BCL2, BCL2L1
35	virus-host interaction	GO:019048	10.8	PDCD6IP, RBX1, VAC14, BECN1, YWHAE, LDLR
36	inflammatory response	GO:006954	10.7	PIK3CG, CNR2, SERPINA3, BMP6, PARK7, P2RX7
37	release of cytochrome c from mitochondria	GO:001836	10.7	CLU, BCL2, BCL2L1, BAX, ATP7A, JUN
38	response to amphetamine	GO:001975	10.7	CNR2, GRIN1, GRIN2A, GRIN2B, DRD1, DRD2
39	response to mechanical stimulus	GO:009612	10.6	RCAN1, BTG2, P2RX7, JUN, MMP9, MAP1B
40	negative regulation of apoptotic process	GO:043066	10.2	PIK3CG, BTG2, BRAF, VEGFA, RAF1, CLU
41	negative regulation of cell proliferation	GO:008285	10.1	WARS, BTG2, SERPINE2, RAF1, LIF, BECN1
42	cellular response to hypoxia	GO:071456	10.0	RBX1, VEGFA, UBB, UBC, HMOX1, TP53
43	MAPK cascade	GO:000165	9.9	RAF1, CDK1, INS, IL18, IL1B, MAPK13
44	response to hypoxia	GO:001666	9.7	VEGFA, RAF1, BCL2, CHRNA7, CHAT, UBQLN1
45	positive regulation of cell proliferation	GO:008284	9.4	CNTF, NBN, VIP, VEGFA, LIF, BCL2L1
46	blood coagulation	GO:007596	9.1	PIK3CB, PIK3CG, SERPINE2, VEGFA, RAF1, CLU
47	platelet activation	GO:030168	9.1	PIK3CB, PIK3CG, VEGFA, RAF1, CLU, YWHAZ
48	positive regulation of peptidyl-serine phosphorylation	GO:033138	8.6	BRAF, VEGFA, RAF1, LIF, BCL2, AVP
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.9	VEGFA, BMP6, LIF, CIITA, UBB, UBC
50	cell death	GO:008219	INF	PINK1, BSCL2, CLN3, CLN8, PARK7, PARK2

Molecular functions related to neurodegeneration according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	20.7	TIMP1, PSEN2, PSMC1, PRKAA1, PRKAA2, PRKCD
2	ATP binding	GO:005524	14.6	PIK3CB, PINK1, PIK3CG, PIK3C3, SGK1, WARS
3	receptor binding	GO:005102	12.1	VCP, LIF, SERPINE2, AVP, AR, GRIN1
4	protein homodimerization activity	GO:042803	11.7	CHKA, CHRNA7, CHEK2, BAX, S100B, P2RX7
5	protein serine/threonine kinase activity	GO:004674	11.4	MARK2, MAPK1, ATM, AKT1, ERN1, DAPK1
6	identical protein binding	GO:042802	11.3	ATXN1, FTL, TNF, GSTM3, S100B, BAX
7	ubiquitin protein ligase binding	GO:031625	11.1	MFN2, CALR, TP53, SUMO1, SNCAIP, NGFR
8	cysteine-type endopeptidase activity	GO:004197	11.0	CASP9, CTSB, CTSL1, CTSL2, CASP8, CASP5
9	transcription factor binding	GO:008134	10.4	NBN, APBB1, GTF2B, AR, JUN, KAT2B
10	enzyme binding	GO:019899	10.3	MAPT, CAT, CASP2, CAV1, AKT1, HMOX1
11	growth factor activity	GO:008083	8.9	BDNF, CNTF, NTF3, NTF4, NRTN, NGF