Neurodegenerative Disease malady

Disease Ontology: A central nervous system disease that results in the progressive deterioration of tissue or organ function or structure, whether due to normal bodily wear or lifestyle choices.⁶

MalaCards: Neurodegenerative Disease, also known as neurodegenerative disorders, is related to neuronitis and neurodegeneration. An important gene associated with Neurodegenerative Disease is PSPN (persephin), and among its related pathways are Neuroscience and Lysosome. The compounds lipid and glutamate have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and prostate, and related mouse phenotypes are behavior/neurological and nervous system.

Wikipedia: Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons,...⁴⁴ more...

Aliases & Descriptions:

neurodegenerative disease 6 8 neurodegenerative disorders 43 neurodegenerative diseases 32

degenerative disorder 43 degenerative disease 6

Diseases related to neurodegenerative disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 829)

id	Related Disease	Score	Top Affiliating Genes
1	neuronitis	56.3	PIK3CA, PINK1, PIK3CG, PIN1, LRP1, NCAM1
2	neurodegeneration	47.2	PINK1, PIK3CG, PIN1, LRP1, RELN, SGK1
3	parkinson's disease	45.1	PINK1, CNR1, CNTF, SERPINF1, SERPINA3, NAT2
4	dementia	43.4	PINK1, PIK3CG, PIN1, LRP1, NCAM1, PDE4A
5	amyotrophic lateral sclerosis	41.9	CNR1, CNTF, SETD2, NAIP, VEGFA, LPL
6	ataxia	40.5	PIK3CA, PIK3CG, PIN1, LRP1, CNTN1, PCSK6
7	retinitis	40.3	PIK3CA, PIK3CG, LRP1, PDE4A, SGK1, CNR1
8	huntington's disease	38.5	CNR1, CNTF, VPS13A, SETD2, SERPINI1, SERPINA3
9	cerebritis	37.9	PIK3CG, LRP1, NCAM1, PDE4A, RELN, SGK1
10	prostatitis	37.6	PIK3CA, PINK1, PIK3CG, PIN1, LRP1, NCAM1
11	multiple system atrophy	36.7	SERPINA3, PARK7, PARK2, BDNF, CHAT, UCHL1
12	schizophrenia	36.5	PIK3CA, PINK1, PIK3CG, NCAM1, PDE4A, RELN
13	leukemia	36.0	PIK3CA, PIK3CG, PIN1, LRP1, NCAM1, PDE4A
14	cadasil	36.0	CNR1, CNTF, SETD2, SERPINI1, SERPINA3, LPL
15	ischemia	35.9	PIK3CA, PIK3CG, NCAM1, PDE4A, SGK1, CNR1
16	tauopathy	35.5	SERPINI1, PARK7, PARK2, CDK5, CDKN3, INA
17	pick's disease	33.9	CLU, PARK7, BDNF, CHAT, UCHL1, MPZ
18	cholesterol	33.5	PIK3CA, PIK3CG, LRP1, RECK, RELN, SGK1
19	alzheimer's disease	33.5	CLU, ITM2B, APOE, APP, MAPT, TTR
20	muscular atrophy	33.4	NCAM1, CNTF, NAIP, BLZF1, PARP1, BCL2
21	spasticity	33.1	CNR1, CNTN2, VEGFA, RAC1, PANK2, SDHA
22	frontotemporal dementia	33.0	PIN1, RELN, SEMA3A, SERPINI1, VCP, PARK2
23	thyroiditis	33.0	PIK3CA, PIK3CG, PIN1, LRP1, NCAM1, PDE4A
24	neurologic diseases	32.9	RECK, RELN, CNTF, CNTN2, GCDH, PARP1
25	krabbe disease	32.8	ARSA, MBP, CASP3, PLA2G4A, PLA2G6, PLA2G2A
26	lateral sclerosis	32.7	MAPT, ALS2, SPAST, SNCA, SOD1
27	brain injury	32.7	NCAM1, CNR1, SERPINI1, VEGFA, BMP6, RAC1
28	supranuclear palsy	32.3	VEGFA, PARK7, PARK2, BCHE, CHAT, CHRM1
29	progressive supranuclear palsy	31.9	PARK7, PARK2, CHAT, CDK5, APOE, APP
30	neuronal ceroid-lipofuscinosis	31.8	SERPINA3, CLN5, CLN6, CLN3, CLN8, BAMBI
31	motor neuron disease	31.6	RET, CNTF, NAIP, NAT2, VEGFA, VCP
32	paraplegia	31.4	BAMBI, SACS, ATXN3, MPZ, CDK5, CDK1
33	intellectual disability	31.4	RELN, BLMH, CLN5, CLN8, BDNF, CHRNA7
34	prion disease	31.3	RECK, CLU, MSMB, ITIH4, FPR2, APP
35	spastic paraplegia	31.1	BAMBI, SACS, ATXN3, MPZ, CDK5, CDK1
36	batten disease	31.0	CLN5, CLN6, CLN3, CLN8, BAMBI, TPP1
37	leukodystrophy	31.0	NCAM1, SDHA, MPZ, ASPA, ARSA, MBP
38	spinocerebellar degeneration	30.8	CHERP, ATXN3, ATXN2, ATXN1, ANP32A, CACNA1A
39	spinal-bulbar muscular atrophy	30.6	CHERP, SACS, ATXN3, ATXN1, AR, HTT
40	corticobasal degeneration	30.6	MAPT, MAPK1, HSPB2, CASP3, HMOX1, SNCA
41	spinocerebellar ataxia type 7	30.6	CHERP, ATXN3, ATXN2, ATXN1, ATN1, ATXN7
42	scrapie	30.3	BLVRB, CLU, MSMB, ITIH4, FLOT1, APOE
43	hereditary spastic paraplegia	30.3	SACS, ATXN3, CDK5, CDK1, MAPK8, SPAST
44	alexander disease	30.3	BLZF1, MTOR, HTT, HSPB1, CASP3, CRYAB
45	vascular dementia	30.3	SERPINA3, VEGFA, BCHE, CHAT, APOE, APP
46	hallervorden-spatz syndrome	30.3	PANK2, FTL, SNCG, SNCB, SNCA, PLA2G6
47	down syndrome	30.2	NCAM1, RET, CNR1, SERPINA3, VEGFA, BMP6
48	alzheimer disease type 2	30.1	SERPINA3, BCHE, CETP, APOE, APP, MAPT
49	alzheimer disease type 1	30.1	APOE, APP, MAPT, PSEN1, PSEN2, CST3
50	semantic dementia	30.0	GRN, APOE, MAPT, RPS27A, TARDBP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to neurodegenerative disease:

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MGI Mouse Phenotypes related to neurodegenerative disease:

²⁵ (show all 30)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	22.6	PIK3CA, PINK1, LRP1, NCAM1, RELN, CNR1
2	nervous system phenotype	MP:0003631	21.1	LRP1, PDE4A, RECK, RELN, CNR1, CNTF
3	mortality/aging	MP:0010768	20.6	PIK3CA, LRP1, NCAM1, RECK, RELN, RET
4	growth/size phenotype	MP:0005378	19.5	PIK3CA, PINK1, PIK3CG, PIN1, LRP1, RECK
5	homeostasis/metabolism phenotype	MP:0005376	18.3	PIK3CA, PINK1, PIK3CG, LRP1, RET, SGK1
6	cellular phenotype	MP:0005384	17.2	PIK3CA, PINK1, PIK3CG, PIN1, NCAM1, RELN
7	immune system phenotype	MP:0005387	15.7	PINK1, LRP1, PDE4A, CNTF, SEMA3A, BLMH
8	integument phenotype	MP:0010771	14.4	PIK3CG, PIN1, RECK, RELN, CNR1, RAC1
9	normal phenotype	MP:0002873	13.9	LRP1, RET, NAIP, VEGFA, PAWR, BDNF
10	hematopoietic system phenotype	MP:0005397	13.7	CNTF, VPS13A, PAWR, BCL2, BCL2L1, UNG
11	muscle phenotype	MP:0005369	13.5	PIK3CA, PIK3CG, LRP1, RELN, RET, CNTF
12	no phenotypic analysis	MP:0003012	13.1	PINK1, RET, SGK1, CNR1, SEMA3A, VEGFA
13	endocrine/exocrine gland phenotype	MP:0005379	13.0	PINK1, RET, PANK2, XRCC4, XDH, MSMB
14	respiratory system phenotype	MP:0005388	12.7	RET, PCSK6, SEMA3A, LPL, LIF, PARK2
15	vision/eye phenotype	MP:0005391	12.6	PIK3CA, PIN1, NCAM1, RELN, CNTN1, PCSK6
16	reproductive system phenotype	MP:0005389	12.5	PIK3CA, RET, RBFOX1, SERPINF1, SEPP1, VEGFA
17	liver/biliary system phenotype	MP:0005370	12.2	RECK, SEPP1, VEGFA, LPL, LIF, CLN3
18	cardiovascular system phenotype	MP:0005385	12.1	PIK3CA, PIK3CG, LRP1, PDE4A, RECK, RET
19	embryogenesis phenotype	MP:0005380	12.1	PIK3CA, RECK, RET, PCSK6, SETD2, BPTF
20	renal/urinary system phenotype	MP:0005367	12.0	RET, SGK1, GCDH, CLU, BCL2, UCHL1
21	craniofacial phenotype	MP:0005382	12.0	PCSK6, BDNF, BAMBI, XRCC4, FOXP2, ASPA
22	digestive/alimentary phenotype	MP:0005381	11.7	RELN, RET, PCSK6, GCG, SERPINF1, VEGFA
23	adipose tissue phenotype	MP:0005375	11.5	PIK3CA, LRP1, CNR1, LPL, LIF, BCL2
24	other phenotype	MP:0005395	11.5	RECK, CNR1, CLU, ATOX1, ATP7B, MME
25	pigmentation phenotype	MP:0001186	11.3	SERPINF1, RAC1, CLN8, BCL2, ATP7A, ATOX1
26	skeleton phenotype	MP:0005390	11.3	PIK3CG, LRP1, RECK, CNR1, SEMA3A, VEGFA
27	taste/olfaction phenotype	MP:0005394	10.8	PDE4A, CNR1, BDNF, MAPT, MAPK1, HTT
28	hearing/vestibular/ear phenotype	MP:0005377	10.7	PARP1, BDNF, BCL2, CHRM1, BAX, P2RX7
29	limbs/digits/tail phenotype	MP:0005371	10.7	RECK, RET, SEPP1, VEGFA, RAC1, BLMH
30	tumorigenesis	MP:0002006	9.3	PIK3CA, RET, BCL2, BCL2L1, UNG, XRCC1

Articles related to neurodegenerative disease:

(show top 50)    (show all 280)

id	Title	Authors	Year	Affiliating Genes
1	Structure of an aprataxin-DNA complex with insights i nto AOA1 neurodegenerative disease. (21984210)	Tumbale P.... Williams R.S.	2011	APTX
2	The role of DYRK1A in neurodegenerative diseases. (21156028)	Wegiel J.... Hwang Y.W.	2011	DYRK1A
3	Targeted chemotherapy in drug-resistant tumors, nonin vasive imaging of P-glycoprotein-mediated functional transport in cancer, and e merging role of Pgp in neurodegenerative diseases. (19949924)	Sivapackiam J.... Sharma V.	2010	ABCB1
4	Omega-3 essential fatty acids modulate initiation and progression of neurodegenerative disease. (20467837)	Palacios-Pelaez R.... Bazan N.G.	2010	ALOX15
5	Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases. (20805224)	Nonaka T.... Hasegawa M.	2010	MAPT, SNCA
6	The effect of prolonged fixation time on immunohistoc hemical staining of common neurodegenerative disease markers. (20010304)	Pikkarainen M.... Alafuzoff I.	2010	MAPT
7	A neurodegenerative disease affecting synaptic connec tions in Drosophila mutant for the tumor suppressor morphogen Patched. (19635474)	Gazi M.... Bhat K.M.	2009	RET
8	A novel technique for simultaneous bilateral brain in fusions in a mouse model of neurodegenerative disease. (19732796)	Bennett S.P.... Potter H.	2009	APOE, SERPINA3
9	The role of lithium in neurodegenerative diseases: n ew registries for old actors (19418288)	PAcrez-MartA-nez D.A.	2009	MAPT
10	Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3'-untranslated region: implications in neurodegenerative diseases. (19019832)	Tapryal N.... Mukhopadhyay C.K.	2009	CAT, CP
11	Tau as a biomarker of neurodegenerative diseases. (20477391)	Schraen-Maschke S.... BuAce L.	2008	MAPT
12	MAPKs as mediators of cell fate determination: an app roach to neurodegenerative diseases. (18336268)	Miloso M.... Tredici G.	2008	MAPK12
13	Emerging roles of S-nitrosylation in protein misfolding and neurodegenerative diseases. (17961071)	Nakamura T.... Lipton S.A.	2008	PARK2
14	Expression of Nrf2 in neurodegenerative diseases. (17204939)	Ramsey C.P.... Jordan-Sciutto K.L.	2007	NFE2L2
15	A brief history of tau: the evolving view of the micr otubule-associated protein tau in neurodegenerative diseases. (17416103)	Lace G.L.... Ince P.G.	2007	MAPT
16	Neuroprotection against neurodegenerative diseases: development of a novel hybrid neuroprotective peptide Colivelin. (17519506)	Chiba T.... Matsuoka M.	2007	CAMK4
17	The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases. (17123092)	KovA!cs G.G.... OvA!di J.	2007	SNCA, HTT
18	Cholesterol dysfunction in neurodegenerative diseases: is Huntington's disease in the list? (17067733)	Valenza M.... Cattaneo E.	2006	APP
19	Anti-inflammatory drugs in the treatment of neurodegenerative diseases: current state. (17017944)	Gilgun-Sherki Y.... Offen D.	2006	COX5A
20	Erythropoietin in the cerebrospinal fluid in neurodegenerative diseases. (16815630)	Brettschneider J.... Tumani H.	2006	EPOR
21	The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases. (16472116)	Sekine Y.... Ichijo H.	2006	MAP3K5
22	Choline acetyltransferase activity at different ages in brain of Ts65Dn mice, an animal model for Down's syndrome and related neurodegenerative diseases. (16539660)	Contestabile A.... Ciani E.	2006	CHAT
23	Dynamic regulation of microglial functions by the non-steroidal anti-inflammatory drug NCX 2216: implications for chronic treatments of neurodegenerative diseases. (16307889)	Bernardo A.... Minghetti L.	2006	PPARG
24	The dardarin G 2019 S mutation is a common cause of Parkinson's disease but not other neurodegenerative diseases. (16102903)	Hernandez D.... Singleton A.	2005	LRRK2
25	Molecular implications of the human glutathione transferase A-4 gene (hGSTA4) polymorphisms in neurodegenerative diseases. (16054170)	Coppede F.... Migliore L.	2005	GSTP1, GSTA4
26	Nature, nurture and neurology: gene-environment interactions in neurodegenerative disease. FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th FEBS Congress in Warsaw. (15885086)	Spires T.L.... Hannan A.J.	2005	HTT
27	Effect of metals on herbicides-alpha-synuclein association: a possible factor in neurodegenerative disease studied by capillary electrophoresis. (16143978)	AndrAc C.... Guillaume Y.C.	2005	SNCA
28	Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative diseases. (16340157)	Wada A.... Kobayashi H.	2005	CTNNB1, HSPA5
29	Exon 3 insert of tau protein in neurodegenerative diseases. (15918074)	Terada S.... Kuroda S.	2005	MAPT
30	Discovering novel phenotype-selective neurotrophic fa ctors to treat neurodegenerative diseases. (14699964)	Petrova P.S.... Commissiong J.W.	2004	MANF
31	Heart fatty acid binding protein as a potential diagnostic marker for neurodegenerative diseases. (15489013)	Steinacker P.... Otto M.	2004	FABP3
32	The neuronal cytoskeleton as a potential therapeutical target in neurodegenerative diseases and schizophrenia. (15581421)	Benitez-King G.... Meza I.	2004	MAPT, MAP2, MAP1B
33	Ironing iron out in Parkinson's disease and other neurodegenerative diseases with iron chelators: a lesson from 6-hydroxydopamine and iron chelators, desferal and VK-28. (15105275)	Youdim M.B.... Ben Shachar D.	2004	TH
34	Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases. (14657205)	Sun G.Y.... Simonyi A.	2004	PLA2G2A
35	PKR activation in neurodegenerative disease. (14989595)	Peel A.L.	2004	MAPK8, CASP8, EIF2AK2
36	alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases. (15170578)	Cairns N.J.... Trojanowski J.Q.	2004	INA
37	Alpha-synuclein aggregation and neurodegenerative diseases. (12719631)	Ma Q.L.... UAcda K.	2003	SNCA
38	Chronic activation of ERK and neurodegenerative diseases. (14579249)	Colucci-D'Amato L.... di Porzio U.	2003	MAPK1, DUSP13
39	Brain-specific proteins in cerebrospinal fluid for the diagnosis of neurodegenerative diseases. (12542908)	Verbeek M.M.... Kremer H.P.	2003	TPPP3
40	Neurodegenerative diseases and Dorfin (14635514)	Niwa J.... Sobue G.	2003	RNF19A
41	Apoptosis by Par-4 in cancer and neurodegenerative diseases. (12565819)	El-Guendy N.... Rangnekar V.M.	2003	PAWR
42	Melatonin oxidative stress and neurodegenerative diseases. (12587715)	Srinivasan V.	2002	SOD1
43	Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. (12084935)	Lee M.K.... Price D.L.	2002	SNCA
44	Pathological glial tau accumulations in neurodegenerative disease: review and case report. (11578782)	Berry R.W.... Binder L.I.	2001	MAPT
45	The effects of APOE genotype on age at onset and progression of neurodegenerative diseases. (11673593)	Chapman J.... Michaelson D.M.	2001	APOE
46	Lactic acid elevation in extramitochondrial childhood neurodegenerative diseases. (11575606)	Kang P.B.... Kaye E.M.	2001	GALC
47	Human T cell lymphotropic virus type I genomic expression and impact on intracellular signaling pathways during neurodegenerative disease and leukemia. (10702386)	Yao J.... Wigdahl B.	2000	CREBBP, CNTN2
48	Neuritic sprouting with aberrant expression of the nitric oxide synthase III gene in neurodegenerative diseases. (10202979)	Sohn Y.K.... de la Monte S.M.	1999	NOS3, NOS2
49	Characterization of a nonsense mutation in the ceruloplasmin gene resulting in diabetes and neurodegenerative disease. (8789443)	Takahashi Y.... Gitlin J.D.	1996	CP
50	Neurotrophic growth factors and neurodegenerative diseases: therapeutic potential of the neurotrophins and ciliary neurotrophic factor. (7838303)	Lindsay R.M.	1994	BDNF, NTF3, CNTF

Genes related to neurodegenerative disease according to GeneCards:

(show top 50)    (show all 459)

id	Symbol	Description	Score	GeneCards Section Context
1	PSPN	persephin	11.0	Summaries
2	ARTN	artemin	11.0	Summaries
3	SNCG	synuclein, gamma (breast cancer-specific protein 1)	11.0	Summaries, Functions, Publications
4	FTL	ferritin, light polypeptide	11.0	Publications, Summaries
5	CLN3	ceroid-lipofuscinosis, neuronal 3	11.0	Publications, Summaries
6	BAIAP2	BAI1-associated protein 2	11.0	Summaries
7	BPTF	bromodomain PHD finger transcription factor	11.0	UniProt Related, Summaries
8	CASP8	caspase 8, apoptosis-related cysteine peptidase	11.0	Summaries, Publications
9	NOS1	nitric oxide synthase 1 (neuronal)	11.0	Publications, Summaries
10	FTH1	ferritin, heavy polypeptide 1	11.0	Summaries
11	ICAM5	intercellular adhesion molecule 5, telencephalin	11.0	Summaries
12	TTBK2	tau tubulin kinase 2	11.0	Summaries
13	ABHD12	abhydrolase domain containing 12	11.0	Summaries
14	SH3TC2	SH3 domain and tetratricopeptide repeats 2	11.0	Summaries
15	RBFOX1	RNA binding protein, fox-1 homolog (C. elegans) 1	11.0	Summaries
16	FXN	frataxin	11.0	Publications
17	SMN1	survival of motor neuron 1, telomeric	11.0
18	AR	androgen receptor	11.0	Publications
19	STH	saitohin	11.0	Publications
20	TPPP3	tubulin polymerization-promoting protein family member 3	11.0	Publications
21	SNCB	synuclein, beta	11.0	Publications
22	CLN5	ceroid-lipofuscinosis, neuronal 5	11.0
23	PQBP1	polyglutamine binding protein 1	11.0
24	PPT2	palmitoyl-protein thioesterase 2	11.0
25	CHERP	calcium homeostasis endoplasmic reticulum protein	11.0	Publications
26	NPC2	Niemann-Pick disease, type C2	11.0	Publications
27	CDK5R1	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	11.0	UniProt Related, Functions, Publications
28	UBFD1	ubiquitin family domain containing 1	11.0
29	PRND	prion protein 2 (dublet)	11.0
30	MT3	metallothionein 3	11.0	Publications
31	NHLRC1	NHL repeat containing 1	11.0
32	MAPT	microtubule-associated protein tau	11.0	Publications
33	GLRX	glutaredoxin (thioltransferase)	11.0	Publications
34	BLMH	bleomycin hydrolase	11.0	Publications
35	INA	internexin neuronal intermediate filament protein, alpha	11.0	Publications
36	NEFL	neurofilament, light polypeptide	11.0	Publications
37	NRTN	neurturin	11.0
38	NTF4	neurotrophin 4	11.0	Publications
39	SRR	serine racemase	11.0
40	SURF1	surfeit 1	11.0	Publications
41	MCOLN1	mucolipin 1	11.0
42	TPP1	tripeptidyl peptidase I	11.0	Publications
43	PSENEN	presenilin enhancer 2 homolog (C. elegans)	11.0
44	RNF19A	ring finger protein 19A, E3 ubiquitin protein ligase	11.0	Publications
45	RTN4R	reticulon 4 receptor	11.0
46	CLN6	ceroid-lipofuscinosis, neuronal 6, late infantile, variant	11.0
47	ATXN8OS	ATXN8 opposite strand (non-protein coding)	11.0
48	CLN8	ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)	11.0
49	BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	11.0
50	TIMM8A	translocase of inner mitochondrial membrane 8 homolog A (yeast)	11.0

Pathways related to neurodegenerative disease according to GeneDecks:

(show top 50)    (show all 165)

id	Pathway	Score	Top Affiliating Genes
1	Neuroscience3	13.9	PINK1, NCAM1, RET, PARK7, PARK2, ATXN1
2	Lysosome20	12.8	CLN5, CLN3, GUSB, ARSA, MCOLN1, GM2A
3	Metabolic pathways20	12.3	CNDP1, GCDH, NAT2, PANK2, BCAT1, SDHA
4	Alzheimers disease20	12.0	LRP1, LPL, SDHA, CDK5, CDK5R1, MME
5	Protein processing in endoplasmic reticulum20	12.0	VCP, PARK2, BCL2, UBQLN1, BAX, P4HB
6	Parkinsons disease20	11.7	PINK1, PARK7, PARK2, SDHA, UCHL1, UBB
7	Alzheimers Disease Pathway36	11.6	LRP1, CDK5, CDK5R1, APOE, APP, MAPT
8	Huntingtons disease20	11.5	BDNF, SDHA, BAX, GRM1, GRM5, HTT
9	Neurotrophin signaling pathway20	11.4	PIK3CA, PIK3CG, RAC1, BDNF, BAX, JUN
10	Apoptosis and survival Role of CDK5 in neuronal death and survival10	11.4	BCL2, CDK5, CDK5R1, CASP9, CYCS, NTRK1
11	TGF-beta Signaling Pathways37	11.2	PIK3CG, RAC1, MTOR, JUN, CDC42, FOXO3
12	p53 Signaling36	11.2	BCL2, UBB, BAX, ATM, MAPK8, MAPK12
13	MAPK signaling pathway20	11.1	RAC1, BDNF, JUN, CDC42, FGF1, FGF2
14	Endothelin-1 Signaling Pathway36	11.1	BMP6, IL16, IL1B, MAPK1, CASP7, CASP3
15	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	11.1	PIK3CA, BCL2, BAX, JUN, CDK5, CDK5R1
16	Colorectal cancer20	11.1	PIK3CG, RAC1, MSH2, MAPK8, CASP9, RHOA
17	CREB Pathway36	11.0	SEMA3A, BMP6, BDNF, FGF1, GRIA2, GRM1
18	Development Neurotrophin family signaling10	11.0	PIK3CA, RAC1, BDNF, BAX, JUN, MAPK8
19	Development_Neurotrophin family signaling41	11.0	PIK3CA, RAC1, BDNF, BAX, JUN, MAPK8
20	TRKA Signaling36	10.9	RAC1, BAX, JUN, CDC42, MAPK8, MAPK1
21	14-3-3 Induced Apoptosis36	10.9	BCL2, JUN, FOXO3, IL1B, MAPK8, MAPK12
22	Amyotrophic lateral sclerosis (ALS)20	10.9	RAC1, BCL2, BCL2L1, BAX, GRIA2, GRIN2A
23	Ceramide Pathway36	10.8	JUN, MAPK8, CASP7, CASP3, CASP6, CASP1
24	TNF Signaling36	10.8	JUN, MAPK8, MAPK12, MAPK1, MAP3K5, CASP7
25	Apoptosis and survival Anti-apoptotic action of nuclear ESR1 and ESR210	10.7	BCL2, BAX, JUN, MAPK8, MAPK1, MAP3K5
26	Molecular Mechanisms of Cancer36	10.7	PIK3CG, SEMA3A, BMP6, LIF, BDNF, BCL2
27	Pathogenesis of ALS36	10.6	BCL2, BCL2L1, BAX, GRIA2, GRIN2A, CASP3
28	NGF Pathway36	10.6	RAC1, BAX, CDC42, FOXO3, MAPK8, MAPK1
29	JNK Pathway36	10.6	BMP6, RAC1, BCL2, BAX, JUN, CDC42
30	Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR241	10.6	BCL2, BAX, JUN, MAPK8, MAPK1, MAP3K5
31	DHA Signaling36	10.6	SEMA3A, SERPINF1, BMP6, BDNF, BCL2, BCL2L1
32	Apoptosis20	10.5	PIK3CA, PIK3CG, BCL2, BCL2L1, BAX, ATM
33	Prostate cancer20	10.4	PIK3CA, PIK3CG, BCL2, MTOR, AR, GSTP1
34	TNF-Induced Apoptosis Implicating Sphingolipids36	10.4	BAX, MAPK8, MAPK12, MAPK1, CASP7, CASP3
35	Apoptosis Signaling Pathways37	10.4	NAIP, BCL2, BCL2L1, BAX, HSPB1, HSP90AA1
36	Estrogen Pathway36	10.3	SEMA3A, BMP6, BDNF, BCL2, JUN, FGF1
37	Apoptotic Pathways Triggered By HIV136	10.3	BCL2, BCL2L1, BAX, MAPK8, MAP3K5, CASP7
38	p53 Mediated Apoptosis36	10.2	SEMA3A, BMP6, BDNF, BCL2, BAX, ATM
39	Mitochondrial Apoptosis36	10.2	SEMA3A, BMP6, BDNF, BCL2, BCL2L1, BAX
40	Pancreatic Adenocarcinoma36	10.2	SEMA3A, BMP6, RAC1, BDNF, BCL2, BCL2L1
41	14-3-3 Induced Intracellular Signaling36	10.1	SEMA3A, BDNF, JUN, FGF1, FGF2, MAPT
42	TGF-Beta Pathway36	10.0	SEMA3A, BMP6, BDNF, BCL2, BAX, JUN
43	Cellular Apoptosis Pathway36	9.9	SEMA3A, BMP6, PAWR, BDNF, BCL2, BCL2L1
44	MAPK Family Pathway36	9.8	SEMA3A, BMP6, RAC1, BDNF, BCL2, BAX
45	PAK Pathway36	9.7	SEMA3A, BMP6, RAC1, LIF, BDNF, BCL2
46	Antioxidant Action of Vitamin-C36	9.7	SEMA3A, BMP6, RAC1, LIF, BDNF, BCL2
47	Pathways in cancer20	9.6	PIK3CA, PIK3CG, RET, VEGFA, RAC1, BCL2
48	JAK-STAT Pathway36	9.6	SEMA3A, BMP6, BDNF, UBB, BAX, JUN
49	PPAR Pathway36	9.4	SEMA3A, FGF1, FGF2, MAPK12, MAPK1, IGF1
50	NF-KappaB (p50-p65) Pathway36	9.4	SEMA3A, BMP6, BDNF, UBA52, UBB, FGF1

Compounds related to neurodegenerative disease according to GeneDecks:

(show top 50)    (show all 665)

id	Compound	Score	Top Affiliating Genes
1	lipid32	19.7	PIK3CA, PIK3CG, LRP1, NCAM1, PDE4A, RECK
2	glutamate32	16.8	PIK3CA, NCAM1, SGK1, CNR1, CNTN2, GCG
3	h2o232	15.3	PIK3CG, PDE4A, SGK1, CNTF, CNTN2, SEPP1
4	glutamine32	14.6	PIK3CG, NCAM1, PDE4A, GCG, LPL, VCP
5	gaba32 42	15.1	NCAM1, RELN, CNR1, CNTF, GCG, BLVRB
6	estrogen32	14.0	GCG, SETD2, SERPINA3, NAT2, LPL, CLU
7	choline32 9 18 9	16.4	RET, CNTF, CNTN2, LIF, BLVRB, BCHE
8	retinoic acid32 42 18	15.2	PIK3CA, PIK3CG, LRP1, NCAM1, PDE4A, RET
9	heparin32 9 18 9	16.1	PIK3CA, PIK3CG, LRP1, NCAM1, RECK, GCG
10	creatinine32	13.0	NCAM1, SGK1, VPS13A, GCG, SERPINA3, BMP6
11	vegf32	12.7	PIK3CA, PIK3CG, LRP1, NCAM1, PDE4A, RECK
12	phospholipid32	12.5	PDE4A, LPL, BLZF1, CLU, SCARB1, CHAT
13	copper32 18	13.4	LIF, BLZF1, MT3, P4HB, ATP7A, ATOX1
14	cocaine32 9 9	14.2	PDE4A, CNR1, CNTF, GCG, BMP6, BDNF
15	mptp32	12.1	PARK2, BDNF, BCL2, BCL2L1, CHRNA7, BAX
16	amine32	12.0	NAT2, BCHE, CHAT, AOC3, MAOA, MAOB
17	dbc-amp32	12.0	LRP1, NCAM1, PDE4A, BMP6, LIF, BDNF
18	gsno32	11.7	SETD2, P4HB, XDH, JUN, CDKN3, GSR
19	phosphatidylcholine32	11.7	CNR1, LPL, RAC1, SCARB1, CHAT, P4HB
20	inositol32	11.7	PDE4A, LPL, BDNF, ITIH4, FGF1, MBP
21	etoposide32 42 9 9	14.4	PIK3CA, PIK3CG, RECK, CNTN2, SETD2, CLU
22	sulforaphane32	11.4	PIK3CG, PARP1, JUN, GSTA1, GSTP1, APEX1
23	dutp32	11.3	CLU, PARP1, BCL2, BCL2L1, UNG, BAX
24	cyclosporin a32 42	12.3	PIK3CA, PIK3CG, PIN1, PDE4A, RECK, CNTN2
25	atropine32 9 9	13.3	GCG, BCHE, CHRNA7, CHRM1, MME, HSPG2
26	cisplatin32 34 9 9	14.3	PIK3CA, SETD2, NAIP, VEGFA, BMP6, RAC1
27	butyrate32	11.1	RET, GCG, SETD2, BMP6, BLZF1, CLU
28	phenylephrine32 9 18 9	14.1	LPL, RAC1, LIF, AR, MAOA, HSPG2
29	s-nitroso-n-acetylpenicillamine32	10.9	PARP1, XDH, IL1B, HSPA4, CASP3, CAT
30	glycerol32 9 18 9	13.9	PDE4A, GCG, LPL, CDK1, ITIH4, MMP2
31	nicotine32 34 9 9	13.7	CYP2A6, CYP2B6, CYP2D6, SLC6A2
32	wortmannin32 42	11.6	PIK3CA, PIK3CG, PDE4A, RET, SGK1, CNTF
33	doxorubicin32 34 9 9	13.5	PIK3CA, PIK3CG, NCAM1, RECK, SETD2, VEGFA
34	dexamethasone32 42 34 9 9	14.5	PIK3CA, LRP1, NCAM1, PDE4A, SGK1, SERPINF1
35	tetracycline32 9 9	12.3	CNTN2, RAC1, MMP2, GUSB, FGF2, CASP1
36	selegiline32 9 9	12.3	BDNF, BCHE, MAOA, MAOB, CAT, TXN
37	valproic acid32 34 9 18 9	14.3	NCAM1, RELN, BDNF, GSR, CACNA1A, CYP1B1
38	diphenyleneiodonium32	10.0	SETD2, SERPINF1, VEGFA, RAC1, XDH, JUN
39	vinblastine32 9 9	12.0	BDNF, BCL2, BCL2L1, BAX, JUN, CDK1
40	quercetin32 42 9 18 9	13.9	PIK3CA, PIK3CG, PARP1, BCL2, BCL2L1, BAX
41	vitamin e succinate32	9.8	BMP6, PARP1, BCL2, BCL2L1, BAX, JUN
42	methotrexate32 34 42 9 9	13.7	SERPINA3, NAT2, BMP6, MMP2, FOLH1, GSR
43	nifedipine32 9 9	11.6	PIK3CG, GCG, BMP6, BDNF, CHAT, ITIH4
44	clozapine32 34 9 9	12.6	CHRNA7, CHRM1, APOD, HTR2A, TNFRSF1B, DRD2
45	ibmx32	9.5	PDE4A, GCG, LPL, BDNF, CDKN3, MME
46	sb 20358032 42	10.2	GCG, SETD2, VEGFA, BMP6, RAC1, LIF
47	celecoxib32 42 34 9 18 9	13.9	PIK3CG, VEGFA, PARP1, BCL2, BAX, MMP2
48	ly29400232	8.8	PIK3CA, PIK3CG, RET, SGK1, GCG, VEGFA
49	herbimycin a32 42	9.8	PIK3CG, RET, BMP6, JUN, CDKN3, MMP2
50	genistein32 9 18 9	11.7	PIK3CA, PIK3CG, RET, CNTF, GCG, SETD2

Cellular components related to neurodegenerative disease according to GeneDecks:

(show all 24)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	17.0	PIK3CG, PIN1, LRP1, RELN, RBFOX1, NAIP
2	nucleus	GO:005634	17.0	PIN1, LRP1, PDE4A, SGK1, CNTF, RBFOX1
3	cytosol	GO:005829	16.4	PIK3CA, PINK1, PIK3CG, PDE4A, CNTF, NAT2
4	plasma membrane	GO:005886	15.9	PIK3CG, NCAM1, RECK, SGK1, CNR1, CNTN1
5	mitochondrion	GO:005739	14.5	PINK1, SGK1, GCDH, CLU, CLN3, CLN8
6	endoplasmic reticulum	GO:005783	13.3	PCSK6, VCP, CLU, CLN5, CLN6, CLN3
7	axon	GO:030424	13.2	CNTF, SEMA3A, PARK7, CHAT, UCHL1, SACS
8	nucleoplasm	GO:005654	13.0	PIN1, PABPN1, PARP1, UBA52, UBB, XRCC1
9	neuronal cell body	GO:043025	12.9	CNTF, CNTN2, CHAT, UCHL1, MTOR, P2RX7
10	perinuclear region of cytoplasm	GO:048471	12.5	PDE4A, CLU, CLN5, PARK2, CHERP, UBQLN1
11	integral to plasma membrane	GO:005887	12.4	LRP1, RET, CNR1, CNTN2, SCARB1, CHRM1
12	Golgi apparatus	GO:005794	12.1	MYEF2, CLN5, CLN3, PARK2, MTPAP, ATP7A
13	lysosome	GO:005764	12.0	CLN5, CLN3, MTOR, ARSA, CAT, GM2A
14	dendrite	GO:030425	12.0	RELN, SEMA3A, MTOR, SACS, ATXN10, CDK5
15	growth cone	GO:030426	11.6	CDK5, CDK5R1, GRIA2, APBB1, MAPT, MAP1B
16	lysosomal lumen	GO:043202	11.5	GUSB, ARSA, HSPG2, GM2A, TPP1, CTSA
17	mitochondrial outer membrane	GO:005741	10.8	PINK1, BCL2, BCL2L1, BAX, MTOR, MAOA
18	melanosome	GO:042470	10.6	SERPINF1, RAC1, P4HB, FLOT1, ANXA2, HSPA5
19	extracellular region	GO:005576	10.5	NCAM1, CNDP1, GCG, SEMA3A, SERPINI1, SERPINF1
20	membrane	GO:016020	10.5	PIK3CG, PDE4A, RECK, CNTN1, PCSK6, SEMA3A
21	postsynaptic density	GO:014069	10.4	CHRM1, CDK5, CDK5R1, ARC, GRIA2, GRIN2A
22	extracellular space	GO:005615	9.6	RELN, CNTF, PCSK6, GCG, SERPINF1, SEPP1
23	secretory granule	GO:030141	9.4	GCG, VEGFA, ATP7A, CDC42, IL1B, PLA2G2A
24	cell surface	GO:009986	9.0	NCAM1, CNTN2, PCSK6, VEGFA, LPL, SCARB1

Biological processes related to neurodegenerative disease according to GeneDecks:

(show top 50)    (show all 74)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell death	GO:008219	14.7	PINK1, CLN5, CLN6, CLN3, CLN8, PARK7
2	negative regulation of neuron apoptotic process	GO:043524	12.6	CNTF, NAIP, CLN3, PARK7, PARK2, BDNF
3	synaptic transmission	GO:007268	12.4	KCNH4, CHRNA7, CHAT, ATXN3, MPZ, CDK5
4	innate immune response	GO:045087	12.3	PIK3CG, PIN1, CLU, BCL2, BCL2L1, UBA52
5	small molecule metabolic process	GO:044281	12.2	PIK3CA, PIK3CG, GCG, GCDH, NAT2, LPL
6	axon guidance	GO:007411	12.2	NCAM1, RELN, CNTN1, CNTN2, SEMA3A, RAC1
7	locomotory behavior	GO:007626	12.1	SEPP1, ATP7A, GRM1, APP, HTT, ALS2
8	nerve growth factor receptor signaling pathway	GO:048011	12.1	PIK3CA, PCSK6, RAC1, UBA52, UBB, MTOR
9	apoptotic process	GO:006915	12.0	SGK1, SEMA3A, RAC1, PAWR, BCL2, BCL2L1
10	nervous system development	GO:007399	11.9	NAIP, VEGFA, CLN8, BDNF, SDHA, CHERP
11	adult walking behavior	GO:007628	11.8	CNTN2, CLN8, CHAT, UCHL1, FXN, MAPT
12	positive regulation of catalytic activity	GO:043085	11.8	BCL2, MT3, ATP7A, HSPB2, CTSA, PSAP
13	response to drug	GO:042493	11.6	PDE4A, LPL, PARK7, BDNF, BCHE, BCL2
14	protein catabolic process	GO:030163	11.6	CLN5, CLN6, CLN3, CLN8, MTOR, AKT1
15	regulation of apoptotic process	GO:042981	11.5	SGK1, VCP, UBA52, UBB, P2RX7, CDK5
16	response to lipopolysaccharide	GO:032496	11.4	CNR1, P2RX7, JUN, MAOB, HSF1, CASP1
17	memory	GO:007613	11.4	CNR1, CHRNA7, CHAT, JPH3, GRIN2A, IL1B
18	neurotransmitter biosynthetic process	GO:042136	11.3	MAOA, ALDH9A1, NOS1, COMT, ACHE, TH
19	peptidyl-serine phosphorylation	GO:018105	11.2	PINK1, BCL2, MTOR, ATM, CDK5, CDK5R1
20	response to wounding	GO:009611	11.2	RAC1, GRIN2A, CASP3, CTSB, NGFR, ACHE
21	response to iron ion	GO:010039	11.1	BCL2, FXN, APBB1, CASP6, DRD2, DBH
22	neuron apoptotic process	GO:051402	11.1	BCL2, BAX, ATM, ATN1, CDK5, APP
23	response to ethanol	GO:045471	11.1	CNR1, BCL2, CHAT, CDK1, GRIN2A, MAOB
24	lipid metabolic process	GO:006629	11.1	LPL, CLU, SCARB1, P4HB, CETP, MGLL
25	associative learning	GO:008306	11.0	RELN, CLN3, CLN8, GLP1R, DRD2, PPT1
26	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	11.0	BCL2, BCL2L1, UBA52, UBB, P2RX7, APP
27	regulation of synaptic plasticity	GO:048167	10.9	BDNF, BAIAP2, CDK5, HTT, CALB1, CTNND2
28	response to heat	GO:009408	10.9	BCL2, IL1B, HSF1, HSPA4, CASP6, AKT1
29	response to toxin	GO:009636	10.9	BCL2, BAX, CDK1, MBP, MAOB, CASP1
30	cellular response to organic substance	GO:071310	10.8	BCL2, BAX, IL1B, MAP2, CALB1, CASP3
31	cellular iron ion homeostasis	GO:006879	10.8	FXN, FTH1, FTL, MCOLN1, HMOX1, ACO1
32	response to hypoxia	GO:001666	10.8	VEGFA, BCL2, CHRNA7, CHAT, UBQLN1, MT3
33	induction of apoptosis by intracellular signals	GO:008629	10.8	CLU, BCL2, BCL2L1, BAX, MAPK8, CASP7
34	sensory perception of pain	GO:019233	10.8	CNR1, P2RX7, CDK5, MME, GRIN2A, GRM1
35	release of cytochrome c from mitochondria	GO:001836	10.8	CLU, BCL2, BCL2L1, BAX, ATP7A, JUN
36	induction of apoptosis by extracellular signals	GO:008624	10.7	RAC1, UBA52, UBB, BAX, MAPK8, MAP3K5
37	aging	GO:007568	10.7	CNR1, SERPINF1, JUN, IL1B, APOD, HTR2A
38	response to nicotine	GO:035094	10.6	CNR1, BCL2, CHRNA7, HMOX1, DRD2, NGF
39	response to pain	GO:048265	10.6	RELN, RET, COMT, TAC1, DBH, PRKCG
40	inflammatory response	GO:006954	10.4	PIK3CG, SERPINA3, BMP6, RAC1, PARK7, P2RX7
41	learning	GO:007612	10.4	CNTN2, BCHE, JUN, ARC, PTN, CTNND2
42	activation of MAPK activity	GO:000187	10.3	CHRNA7, UBA52, UBB, P2RX7, CDK1, FGF2
43	anti-apoptosis	GO:006916	10.3	PIK3CA, NAIP, BDNF, BCL2, BCL2L1, UBA52
44	positive regulation of neuron apoptotic process	GO:043525	10.3	BAX, ATM, JUN, CDK5, CDK5R1, MAP3K11
45	xenobiotic metabolic process	GO:006805	10.2	NAT2, GSTA1, GSTA2, GSTA3, GSTA4, GSTO1
46	positive regulation of apoptotic process	GO:043065	10.2	CNR1, CLU, PAWR, BAX, P2RX7, ATM
47	cellular response to hypoxia	GO:071456	10.1	VEGFA, UBA52, UBB, MT3, MTOR, HMOX1
48	negative regulation of apoptotic process	GO:043066	10.0	PIK3CG, GCG, VEGFA, CLU, CLN3, CLN8
49	fibroblast growth factor receptor signaling pathway	GO:008543	9.9	PIK3CA, UBA52, UBB, MTOR, CDK1, FOXO3
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.4	VEGFA, BMP6, LIF, UBA52, UBB, JUN

Molecular functions related to neurodegenerative disease according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	18.5	SLC6A4, PSEN1, STUB1, SYVN1, TARDBP, TACR1
2	ATP binding	GO:005524	12.8	SRR, SPAST, SPG7, NTRK1, NTRK2, DYRK1A
3	copper ion binding	GO:005507	11.6	TYR, DBH, PRND, PRNP, SOD1, CP
4	enzyme binding	GO:019899	11.5	CYP2A6, CTNNB1, PPARG, NFKBIA, ABCD1, STUB1
5	receptor binding	GO:005102	11.5	PSPN, NOS2, NRTN, PPP2R4, PRDX5, POMC
6	identical protein binding	GO:042802	11.5	SNCA, PTS, TNF, AKT1, GLUL, GLUD1
7	protein homodimerization activity	GO:042803	11.3	GDNF, SRR, PTS, HMOX1, CAT, HSP90AA1
8	cysteine-type endopeptidase activity	GO:004197	11.3	CTSL1, CTSB, CASP9, CASP8, CARD17, CASP1
9	drug binding	GO:008144	11.3	PPARA, SLC6A3, SLC18A2, SIGMAR1, PPARG, CYP2D6
10	ubiquitin protein ligase binding	GO:031625	11.2	NGFR, NFKBIA, TF, DNM1L, STUB1, PML
11	electron carrier activity	GO:009055	10.8	CYP2A6, CYP2B6, CYP2D6, CYP4X1, CYP27A1, CYP3A5
12	beta-amyloid binding	GO:001540	10.7	CST3, ACHE, HSD17B10, APOE, APBB1, ITM2B
13	nerve growth factor binding	GO:048406	10.6	PCSK6, NTF3, NTRK1, NGFR, SORT1
14	iron ion binding	GO:005506	10.4	CYCS, CYP4X1, CYP27A1, CYP3A5, CYP2J2, NOS1
15	growth factor activity	GO:008083	9.9	IGF1, PTN, NTF3, NTF4, NRTN, NGF
16	heme binding	GO:020037	9.9	CYP4X1, CYP27A1, CYP3A5, CYP2J2, NOS1, NOS2