MCID: NRD001
MIFTS: 32

Neurodermatitis

Categories: Skin diseases, Neuronal diseases

Aliases & Classifications for Neurodermatitis

MalaCards integrated aliases for Neurodermatitis:

Name: Neurodermatitis 12 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:3309
MeSH 42 D009450
NCIt 47 C111963
SNOMED-CT 64 156383005 267854005
UMLS 69 C0027822

Summaries for Neurodermatitis

MalaCards based summary : Neurodermatitis is related to prurigo nodularis and atopic dermatitis. An important gene associated with Neurodermatitis is MS4A2 (Membrane Spanning 4-Domains A2). The drugs Peripheral Nervous System Agents and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and eye, and related phenotype is Decreased shRNA abundance (Z-score < -2).

Related Diseases for Neurodermatitis

Diseases related to Neurodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
id Related Disease Score Top Affiliating Genes
1 prurigo nodularis 11.2
2 atopic dermatitis 11.2
3 denture stomatitis 10.6 POMC TCOF1
4 tibial nerve palsy 10.6 POMC TCOF1
5 iritis 10.6 FEZF1 FEZF2
6 ascending colon cancer 10.6 FEZF1 FEZF2
7 rete ovarii adenocarcinoma 10.5 FEZF1 FEZF2
8 non-gestational choriocarcinoma 10.5 POMC TAC1
9 substance dependence 10.5 FEZF1 FEZF2
10 mental retardation, autosomal recessive 54 10.4 NPS TAC1
11 acute cervicitis 10.4 EHF KNG1
12 gerstmann syndrome 10.4 CABIN1 POMC
13 boutonneuse fever 10.3 NPS TAC1
14 guillain-barre syndrome 10.3 KANTR POMC
15 eyelid neoplasm 10.2 MS4A2 NPS TAC1
16 retinal hemangioblastoma 10.2 KANTR TAC1
17 acute gonococcal epididymo-orchitis 10.2 KANTR TCOF1
18 thrombocytopenia due to platelet alloimmunization 10.2 KANTR POMC
19 chronic tubotympanic suppurative otitis media 10.1 KANTR POMC
20 epulis 10.1 NPS TAC1
21 focal hand dystonia 10.1 KANTR TAC1
22 psoriasis 10.0
23 cataract 10.0
24 dermatitis 10.0
25 hemopericardium 10.0 NPS TAC1
26 tubular variant testicular seminoma 9.9 KANTR NPS
27 asthma 9.8
28 alopecia 9.8
29 craniopharyngioma 9.7 KANTR POMC
30 atopy 9.6
31 mycosis fungoides 9.6
32 reticulum cell sarcoma 9.6
33 arthritis 9.6
34 skin conditions 9.6
35 erythema multiforme 9.6
36 sarcoma 9.6
37 urticaria 9.6
38 lymphadenitis 9.6
39 keratoacanthoma 9.6
40 purpura 9.6
41 retinitis 9.6
42 tuberculosis 9.6
43 occupational dermatitis 9.6
44 retinal detachment 9.6
45 lupus erythematosus 9.6
46 alopecia areata 9.6
47 bowen's disease 9.6
48 headache 9.6
49 angiomyolipoma 4.8 BTK CABIN1 DDX21 DECR1 EHF FEZF1

Graphical network of the top 20 diseases related to Neurodermatitis:



Diseases related to Neurodermatitis

Symptoms & Phenotypes for Neurodermatitis

GenomeRNAi Phenotypes related to Neurodermatitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.23 POMC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.23 IKBKB
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.23 IKBKB
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-38 9.23 IKBKB
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.23 BTK IKBKB POMC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.23 BTK

Drugs & Therapeutics for Neurodermatitis

Drugs for Neurodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
2 Analgesics Phase 4,Phase 2,Phase 3
3 Analgesics, Non-Narcotic Phase 4,Phase 2
4 Dermatologic Agents Phase 4
5 Efamol Phase 4
6 Hypolipidemic Agents Phase 4
7 Anti-Inflammatory Agents Phase 4,Phase 2
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2
9 Lipid Regulating Agents Phase 4
10 Antimetabolites Phase 4
11 Antirheumatic Agents Phase 4,Phase 2
12 Olive Nutraceutical Phase 4
13 Evening Primrose Nutraceutical Phase 4
14 Linoleate Nutraceutical Phase 4
15
Selegiline Approved, Investigational, Vet_approved Phase 3 14611-51-9 26757 5195
16
Nalbuphine Approved Phase 2, Phase 3 20594-83-6 5360630 5311304
17 Central Nervous System Depressants Phase 2, Phase 3
18 Narcotic Antagonists Phase 2, Phase 3
19 Narcotics Phase 2, Phase 3
20 Analgesics, Opioid Phase 2, Phase 3
21 Antipruritics Phase 2, Phase 3
22
Apremilast Approved, Investigational Phase 2 608141-41-9 11561674
23
Substance P Investigational Phase 2 33507-63-0 44359816
24 Serlopitant Investigational Phase 2 860642-69-9
25 Neurotransmitter Agents Phase 2
26 neurokinin A Phase 2
27 Neurokinin-1 Receptor Antagonists Phase 2
28 Angiogenesis Inhibitors Phase 2
29 Angiogenesis Modulating Agents Phase 2
30 Anti-Bacterial Agents Phase 2
31 Anti-Infective Agents Phase 2
32 Immunosuppressive Agents Phase 2
33
Citalopram Approved 59729-33-8 2771
34
Dapsone Approved, Investigational 80-08-0 2955
35
leucovorin Approved, Nutraceutical 58-05-9 143 6006
36
Folic Acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
37
Serotonin 50-67-9 5202
38 Cholinergic Agents
39 Muscarinic Antagonists
40 Cholinergic Antagonists
41 Serotonin Agents
42 Serotonin Uptake Inhibitors
43 Neurotransmitter Uptake Inhibitors
44 Parasympatholytics
45 Antidepressive Agents
46 Antidepressive Agents, Second-Generation
47 Psychotropic Drugs
48 Autonomic Agents
49 Antiparkinson Agents
50 Folic Acid Antagonists

Interventional clinical trials:

(show all 11)

id Name Status NCT ID Phase Drugs
1 Investigation of Efficacy and Safety of EPOGAM Completed NCT00878670 Phase 4 EPOGAM 1000
2 Study About Effectiveness of Silver-Containing Textiles for Treatment of Acute Neurodermatitis Completed NCT00196430 Phase 3 corticosteroid
3 Study of Nalbuphine HCl ER Tablets in Patients With Prurigo Nodularis Completed NCT02174419 Phase 2, Phase 3 nalbuphine HCl ER tablets 90 mg BID;nalbuphine HCl ER tablets 180 mg BID;Placebo tablets BID
4 Clinical Research Study to Evaluate Selegiline in the Treatment of Borderline Personality Disorder Completed NCT01912391 Phase 3 Selegiline;Placebo (for Selegiline)
5 Open Label Extension Study of Nalbuphine HCl ER in Patients With Prurigo Nodularis Active, not recruiting NCT02174432 Phase 2, Phase 3 nalbuphine HCl ER 90 mg BID;nalbuphine HCl ER 120 mg BID;nalbuphine HCl ER 180 mg BID
6 A Randomized Placebo-Controlled Study of the Neurokinin-1 (NK1) Receptor Antagonist Serlopitant Prurigo Nodularis (PN) Completed NCT02196324 Phase 2 serlopitant;Placebo
7 Safety and Efficacy of CC-10004 for Prurigo Nodularis Completed NCT00869089 Phase 2 CC-10004
8 Effectiveness of the Selective Serotonin Reuptake Inhibitor,Citalopram (Cipralex), in Prurigo Nodularis Unknown status NCT00532519 citalopram (cipralex)
9 Prevalence of Food Allergies to Proteins From Different Legumes Completed NCT01728168
10 The Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar Dermatosis Recruiting NCT02732145
11 Dapsone Prurigo Study Not yet recruiting NCT01870050 Dapsone gel - verum

Search NIH Clinical Center for Neurodermatitis

Cochrane evidence based reviews: neurodermatitis

Genetic Tests for Neurodermatitis

Anatomical Context for Neurodermatitis

MalaCards organs/tissues related to Neurodermatitis:

39
Skin, Testes, Eye

Publications for Neurodermatitis

Articles related to Neurodermatitis:

(show top 50) (show all 129)
id Title Authors Year
1
Rasch analysis holds no brief for the use of the Dermatology Life Quality Index (DLQI) in Chinese neurodermatitis patients. ( 26841932 )
2016
2
A case of neurodermatitis circumscipta of scalp presenting as patchy alopecia. ( 24403775 )
2013
3
Quality of life of patients with neurodermatitis. ( 23533146 )
2013
4
Autoerythrocyte sensitization syndrome presenting with general neurodermatitis. ( 23956968 )
2013
5
Autoerythrocyte sensitization syndrome presenting with general neurodermatitis: factitious purpura or psychophysiological entity? ( 23205328 )
2012
6
Sexual dysfunction in female patients with neurodermatitis. ( 20864649 )
2011
7
Sexual dysfunctions in patients with neurodermatitis and psoriasis. ( 18224550 )
2008
8
Clinical and histopathological findings of 'psoriatic neurodermatitis' and of typical lichen simplex chronicus. ( 17567313 )
2007
9
Treatment of the localized neurodermatitis by plum-blossom needle tapping and with the modified yangxue dingfeng tang--a clinical observation of 47 cases. ( 17078443 )
2006
10
Lichen simplex chronicus (atopic/neurodermatitis) of the anogenital region. ( 14756886 )
2004
11
Professor Ouyang Heng's experience in treating neurodermatitis. ( 14535180 )
2003
12
The effect of topically applied aspirin on localized circumscribed neurodermatitis. ( 11712038 )
2001
13
Effects of Medical Resonance Therapy Music on patients with psoriasis and neurodermatitis--a pilot study. ( 11286371 )
2000
14
Acupuncture treatment of 139 cases of neurodermatitis. ( 10437249 )
1997
15
Psychiatric profile of patients with neurodermatitis. ( 9141851 )
1996
16
Acupuncture treatment of 139 cases of neurodermatitis. ( 8501956 )
1993
17
Treatment of prurigo nodularis, chronic prurigo and neurodermatitis circumscripta with topical capsaicin. ( 1362846 )
1992
18
Effectiveness of ketotifen in the treatment of neurodermatitis in childhood. ( 2128829 )
1990
19
Cryosurgical treatment of nodular neurodermatitis with Refrigerant 12. ( 2619792 )
1989
20
Calcitonin gene-related peptide immunoreactivity in prurigo nodularis: a comparative study with neurodermatitis circumscripta. ( 2474315 )
1989
21
Podiatric implications of neurodermatitis. ( 3385615 )
1988
22
Association of affective disorder with migraine headaches and neurodermatitis. ( 3360315 )
1988
23
Treatment of 86 cases of local neurodermatitis by electro-acupuncture (with needles inserted around diseased areas). ( 3497316 )
1987
24
A controlled study of psychosocial factors in neurodermatitis. ( 21927162 )
1986
25
Outgrowing a neurodermatitis. ( 3466887 )
1986
26
Vitiligo and neurodermatitis circumscripta. ( 3843332 )
1985
27
Neurodermatitis treated by plum-blossom needle. ( 6570497 )
1984
28
Psychological evaluation of patients with neurodermatitis circumscripta (lichen simplex chronicus). ( 6642567 )
1983
29
The behavioral treatment of neurodermatitis through habit-reversal. ( 7271697 )
1981
30
On the treatment of neurodermatitis with a monoamine oxidase inhibitor. The chemotherapy of psychosomatic illness through A-REM suppression. ( 203659 )
1978
31
A follow-up study on the chemotherapy of neurodermatitis with a monoamine oxidase inhibitor. ( 650199 )
1978
32
Brief hypnotherapy of neurodermatitis: a case with four-year followup. ( 696664 )
1978
33
Neurodermatitis and intralesional steroids. ( 668973 )
1978
34
Neurodermatitis--a concept. ( 648168 )
1978
35
Neurodermatitis: a skin condition that affects surgical wound healing. ( 893969 )
1977
36
Atopic neurodermatitis. Clinical aspects. ( 1186669 )
1975
37
Epidermal nicotinamide adenine dinucleotides in psoriasis and neurodermatitis (lichen simplex hypertrophicus). ( 239643 )
1975
38
Atopy in lichen simplex (neurodermatitis circumscripta). ( 4802403 )
1973
39
Multiple keratoacanthoma-like neurodermatitis nodularis. ( 4664554 )
1972
40
Neurodermatitis: what is it? ( 20468757 )
1972
41
Peptic ulcer alternating with neurodermatitis circumscripta. ( 5018267 )
1972
42
Therapy in a case of neurodermatitis. ( 5293522 )
1970
43
Neurodermatitis. A case report. ( 5495837 )
1970
44
Glyceraldehydephosphate dehydrogenase and glucose-6-phosphate dehydrogenase activities in psoriasis and neurodermatitis and the effect of dithranol. ( 5412727 )
1970
45
Treatment of neurodermatitis by behavior therapy: a case study. ( 5734560 )
1968
46
Studies in the transaminase, cholinesterase, and alkaline phosphatase activity in the serum of patients with disseminated neurodermatitis. ( 4229781 )
1967
47
Aetiology of neurodermatitis. ( 5915648 )
1966
48
NEURODERMATITIS. ( 14274399 )
1965
49
THE IMPORTANCE OF NEURODERMATITIS. ( 14263629 )
1965
50
HYPNOTHERAPY IN NEURODERMATITIS: A CASE REPORT. ( 14259925 )
1965

Variations for Neurodermatitis

Expression for Neurodermatitis

Search GEO for disease gene expression data for Neurodermatitis.

Pathways for Neurodermatitis

GO Terms for Neurodermatitis

Biological processes related to Neurodermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.56 IKBKB KNG1 MS4A2 TAC1
2 neuropeptide signaling pathway GO:0007218 9.33 NPS POMC TAC1
3 positive regulation of synaptic transmission, GABAergic GO:0032230 8.96 NPS TAC1
4 positive regulation of action potential GO:0045760 8.62 NPS TAC1

Molecular functions related to Neurodermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 8.8 BTK KNG1 POMC

Sources for Neurodermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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