MCID: NRC020
MIFTS: 51

Neuroectodermal Tumor malady

Neuronal diseases, Cancer diseases categories

Summaries for Neuroectodermal Tumor

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Wikipedia:63 A neuroectodermal tumor is a tumor of the central or peripheral nervous system. more...

MalaCards based summary: Neuroectodermal Tumor, also known as neuroectodermal tumors, is related to melanotic neuroectodermal tumor and peripheral primitive neuroectodermal tumor. An important gene associated with Neuroectodermal Tumor is GFAP (glial fibrillary acidic protein), and among its related pathways are Notch Pathway and Nuclear signaling by ERBB4. The compounds eosin and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and uterus, and related mouse phenotypes are muscle and behavior/neurological.

Aliases & Classifications for Neuroectodermal Tumor

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH
See all sources

Neuroectodermal Tumor, Aliases & Descriptions:

Name: Neuroectodermal Tumor 9
Neuroectodermal Tumors 43 60
 
Primitive Neuroectodermal Neoplasm 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:171
NCIt38 C3716
SNOMED-CT55 253096008, 73676002
MeSH33 D017599

Related Diseases for Neuroectodermal Tumor

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Diseases related to Neuroectodermal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 211)
idRelated DiseaseScoreTop Affiliating Genes
1melanotic neuroectodermal tumor32.5SYP
2peripheral primitive neuroectodermal tumor32.1EWSR1, CD99
3ewing sarcoma31.7MYC, MYCN, EWSR1
4cerebral primitive neuroectodermal tumor31.7MYC, MYCN
5pineoblastoma31.2GFAP, SYP
6ewing's family of tumors31.1CD99, EWSR1
7childhood medulloblastoma31.1MYCN, MYC
8rhabdoid tumor31.1PTPRC, VIM, SYP
9extraosseous ewing's sarcoma31.1EWSR1, CD99
10teratoma31.0CD99, GFAP
11fibrous histiocytoma30.9EWSR1
12neuroblastoma30.9TP53, MYCN, MYC, SYP
13sarcoma30.8EWSR1, PTPRC, TP53, VIM, MYCN, S100B
14gliosarcoma30.8GFAP
15ganglioglioma30.6GFAP, SYP, S100B
16olfactory neuroblastoma30.6SYP, S100B, CD99
17embryonal rhabdomyosarcoma30.5PTPRC, EWSR1, MYCN
18clear cell sarcoma30.5S100B, EWSR1
19lymphoblastic lymphoma30.4CD99, PTPRC
20gastrointestinal stromal tumor30.4VIM, S100B
21paraganglioma30.4S100B, SYP, GFAP
22neurofibroma30.3VIM, SYP, S100B
23wilms tumor30.3EWSR1, TP53
24stomach cancer30.0TP53, MYC, RASSF1
25ependymoma30.0GFAP, VIM, SYP, RASSF1, S100B
26medulloblastoma30.0GFAP, S100B, RASSF1, SYP, IFNB1, MYC
27malignant glioma29.9SYP, IFNB1, TP53, GFAP
28retinoblastoma29.7GFAP, PTPRC, TP53, MYCN, MYC, SYP
29rhabdomyosarcoma29.7EWSR1, PTPRC, TP53, VIM, MYCN, S100B
30glioblastoma29.7GFAP, TP53, MYCN, MYC, RASSF1, S100B
31leukemia29.5EWSR1, PTPRC, TP53, MYCN, MYC, IFNB1
32breast cancer29.4RASSF1, IFNB1, MYC, MYCN, TP53
33astrocytoma29.3GFAP, TP53, VIM, IFNB1, SYP, RASSF1
34melanoma28.3EWSR1, PTPRC, TP53, VIM, MYCN, MYC
35supratentorial primitive neuroectodermal tumor10.9
36cerebritis10.7
37giant cell glioblastoma10.6GFAP
38dysembryoplastic neuroepithelial tumor10.6SYP
39mixed glioma10.5GFAP
40neurilemmoma10.5GFAP
41gliomatosis cerebri10.5GFAP
42atypical teratoid rhabdoid tumor10.4
43prostatitis10.4
44binswanger's disease10.4GFAP, SYP
45rhabdoid meningioma10.4GFAP, VIM
46astroblastoma10.4GFAP, VIM
47central neurocytoma10.4GFAP, SYP
48glomus tumor10.4SYP, VIM
49neuronitis10.4
50intracranial primitive neuroectodermal tumor10.4

Graphical network of the top 20 diseases related to Neuroectodermal Tumor:



Diseases related to neuroectodermal tumor

Symptoms for Neuroectodermal Tumor

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Drugs & Therapeutics for Neuroectodermal Tumor

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Drug clinical trials:

Search ClinicalTrials for Neuroectodermal Tumor

Search NIH Clinical Center for Neuroectodermal Tumor

Genetic Tests for Neuroectodermal Tumor

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Anatomical Context for Neuroectodermal Tumor

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MalaCards organs/tissues related to Neuroectodermal Tumor:

31
Kidney, Bone, Uterus, Brain, Breast, Ovary, Adrenal gland, Spinal cord, Cervix, Pancreas, Prostate, Liver, Lung, Thyroid, Testis, Pineal, Bone marrow, Lymph node, Thymus, Heart, Colon, Testes, T cells, Cortex, Cerebellum, Retina, Skin, Myeloid, B lymphoblasts

Animal Models for Neuroectodermal Tumor or affiliated genes

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MGI Mouse Phenotypes related to Neuroectodermal Tumor:

35 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3EWSR1, GFAP, TP53, VIM, MYCN, MYC
2MP:00053868.0S100B, MYC, MYCN, VIM, TP53, GFAP
3MP:00053818.0GFAP, PTPRC, TP53, MYCN, MYC
4MP:00030128.0PTPRC, TP53, MYCN, MYC, IFNB1, SYP
5MP:00053907.8EWSR1, PTPRC, TP53, MYCN, MYC, IFNB1
6MP:00053857.7GFAP, TP53, VIM, MYCN, MYC, RASSF1
7MP:00020067.7EWSR1, PTPRC, TP53, MYC, IFNB1, RASSF1
8MP:00053787.6EWSR1, GFAP, PTPRC, TP53, VIM, MYCN
9MP:00053977.5EWSR1, PTPRC, TP53, VIM, MYCN, MYC
10MP:00036317.4GFAP, PTPRC, TP53, VIM, MYCN, MYC
11MP:00053847.3EWSR1, GFAP, PTPRC, TP53, VIM, MYCN
12MP:00107687.1EWSR1, GFAP, PTPRC, TP53, VIM, MYCN
13MP:00053877.0EWSR1, GFAP, PTPRC, TP53, VIM, MYC
14MP:00053767.0GFAP, PTPRC, TP53, VIM, MYCN, MYC
15MP:00028736.4S100B, EWSR1, GFAP, PTPRC, TP53, MYCN

Publications for Neuroectodermal Tumor

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Articles related to Neuroectodermal Tumor:

(show top 50)    (show all 879)
idTitleAuthorsYear
1
Primitive neuroectodermal tumor with kidney involvement: a case report. (25035703)
2014
2
Melanotic neuroectodermal tumor of infancy disseminated by a ventriculoperitoneal shunt and diagnosed from the inguinal sac. (23823108)
2014
3
Acute transient parotitis in a child with primitive neuroectodermal tumor after a standard dose etoposide. (25006307)
2014
4
Conservative multimodal management of a primitive neuroectodermal tumor of the thyroid. (23888220)
2013
5
Rare pulmonary primitive neuroectodermal tumor metastasizing to the right atrium: a case report. (22392199)
2012
6
Low-grade bone lesions in survivors of childhood medulloblastoma/primitive neuroectodermal tumor. (22054800)
2012
7
Primitive neuroectodermal tumor/Ewing's sarcoma of the urinary bladder: a case report and its molecular diagnosis. (21063743)
2011
8
Primary primitive neuroectodermal tumor of the urinary bladder: a case report and literature review. (20852971)
2011
9
Paravaginal peripheral primitive neuroectodermal tumor: A rare tumor. (22557788)
2011
10
Melanotic neuroectodermal tumor of infancy in oral cavity at unusual age. (20704481)
2010
11
Primitive neuroectodermal tumors in patients with testicular germ cell tumors usually resemble pediatric-type central nervous system embryonal neoplasms and lack chromosome 22 rearrangements. (20348883)
2010
12
Inferior vena cava thrombus in renal primitive neuroectodermal tumor is not rare. (20690331)
2010
13
Uterine primitive neuroectodermal tumor: a case report. (18523790)
2009
14
Dumbbell-shaped peripheral primitive neuroectodermal tumor of the spine--case report and review of the literature. (19050994)
2009
15
Uncommon pleural effusion: pleuropulmonary metastasis from primitive neuroectodermal tumor. (19618040)
2009
16
Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases. (18452568)
2009
17
Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation. (19390556)
2009
18
Melanotic neuroectodermal tumor of infancy: a case report. (18704448)
2008
19
Primary primitive neuroectodermal tumor of the uterus: a case report. (17823807)
2008
20
Primitive neuroectodermal tumor of the kidney confirmed by fluorescence in situ hybridization. (17366107)
2007
21
Primitive neuroectodermal tumor arising in a testicular teratoma with retroperitoneal metastasis: report of an interesting case with review of literature. (17991577)
2007
22
Neonatal macrocephaly: cerebral primitive neuroectodermal tumor or neuroblastoma as an infrequent cause--a case report and review of the literature. (17909991)
2007
23
A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group study. (17932894)
2007
24
Renal primitive neuroectodermal tumor in childhood with intracardiac extension. (16904470)
2006
25
Quantitative mRNA expression analysis of neurotrophin-receptor TrkC and oncogene c-MYC from formalin-fixed, paraffin-embedded primitive neuroectodermal tumor samples. (17080715)
2006
26
Untreated pediatric primitive neuroectodermal tumor in vivo: quantitation of taurine with MR spectroscopy. (16118174)
2005
27
Somatostatin receptor subtype 2 is expressed by supratentorial primitive neuroectodermal tumors of childhood and can be targeted for somatostatin receptor imaging. (15131035)
2004
28
Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. (12594313)
2003
29
Primitive neuroectodermal tumor of the cervix: a clinicopathologic and immunohistochemical study of two cases. (12376920)
2002
30
Extraaxial primitive neuroectodermal tumor mimicking a vestibular schwannoma: diagnostic and therapeutic difficulties. Report of two cases. (11302660)
2001
31
Role of MAP kinase pathways in primitive neuroectodermal tumors. (11724348)
2001
32
Intense p53 staining is a valuable prognostic indicator for poor prognosis in medulloblastoma/central nervous system primitive neuroectodermal tumors. (11451203)
2001
33
Melanotic Neuroectodermal Tumor of Infancy: Clinicopathologic Study of a Case, with Emphasis on the Chemotherapeutic Effects. (11493999)
2000
34
Molecular biology of the Ewing's sarcoma/primitive neuroectodermal tumor family. (10623711)
2000
35
Primary primitive neuroectodermal tumor of the cauda equina. (10987262)
2000
36
Bone morphogenetic proteins-2 and -4 attenuate apoptosis in a cerebellar primitive neuroectodermal tumor cell line. (10336254)
1999
37
Documentation of EWS gene rearrangements by fluorescence in-situ hybridization (FISH) in frozen sections of Ewing's sarcoma-peripheral primitive neuroectodermal tumor. (10078922)
1999
38
The Ewing tumor family of peripheral primitive neuroectodermal tumors expresses human gastrin-releasing peptide. (9622091)
1998
39
Centrosome amplification as a possible mechanism for numerical chromosome aberrations in cerebral primitive neuroectodermal tumors with TP53 mutations. (10072601)
1998
40
Brief report. Melanotic neuroectodermal tumor of infancy located in the skull. (9835920)
1998
41
Primitive neuroectodermal tumor of the cervix uteri. A case report. (9065588)
1997
42
Renal primitive neuroectodermal tumor: a morphologic, cytogenetic, and molecular analysis with the establishment of two cultured cell lines. (9559290)
1997
43
Melanotic neuroectodermal tumor of infancy in the epididymis. Case report and literature review. (8961502)
1996
44
Malignant peripheral neuroectodermal tumors in urology. (8528296)
1995
45
TGF beta 1 and TGF beta 2 are potential growth regulators for medulloblastomas, primitive neuroectodermal tumors, and ependymomas: evidence in support of an autocrine hypothesis. (8200640)
1994
46
Secretogranin II expression in Ewing's sarcomas and primitive neuroectodermal tumors. (1342962)
1992
47
Ultrastructural characteristics of a cell line derived from a melanotic neuroectodermal tumor of infancy. (1648614)
1991
48
Overexpression of the pseudoautosomal gene MIC2 in Ewing's sarcoma and peripheral primitive neuroectodermal tumor. (1695726)
1990
49
Melanotic neuroectodermal tumor of infancy. (2856802)
1986
50
Melanotic neuroectodermal tumor of infancy: its histological similarities to fetal pineal gland. (851944)
1977

Variations for Neuroectodermal Tumor

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Expression for genes affiliated with Neuroectodermal Tumor

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Search GEO for disease gene expression data for Neuroectodermal Tumor.

Pathways for genes affiliated with Neuroectodermal Tumor

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Compounds for genes affiliated with Neuroectodermal Tumor

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Compounds related to Neuroectodermal Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1eosin439.8VIM, GFAP, S100B
2mucicarmine439.7VIM, S100B, SYP
3s 100439.6VIM, SYP, GFAP, S100B
4reticulin439.6S100B, VIM, SYP, GFAP
5catecholamine439.4MYCN, SYP, S100B, VIM
6ganglioside439.4GFAP, PTPRC, VIM, SYP
7b 723439.3S100B, SYP, VIM, PTPRC
8hmba439.3MYC, MYCN, TP53
9choline43 24 1211.2VIM, SYP, S100B, GFAP
10agarose439.1PTPRC, MYCN, MYC, S100B
11hematoxylin439.1S100B, GFAP, VIM, SYP, PTPRC
12formaldehyde43 2410.1VIM, PTPRC, GFAP, SYP, S100B
13temozolomide43 1210.0IFNB1, TP53, VIM
14agar439.0RASSF1, VIM, GFAP, MYC, MYCN
15adriamycin439.0VIM, TP53, MYCN, MYC
16chloramphenicol43 2 49 1212.0IFNB1, S100B, MYCN, VIM, MYC
17glutamine438.9EWSR1, S100B, SYP, GFAP, VIM
18leucine438.9GFAP, MYCN, MYC, SYP, S100B, VIM
19acth438.9S100B, GFAP, PTPRC, SYP, IFNB1
20iron43 249.8MYCN, S100B, IFNB1, VIM, GFAP
21bromodeoxyuridine438.8S100B, GFAP, VIM, MYCN, MYC, IFNB1
22dbc-amp438.8GFAP, VIM, MYCN, S100B, SYP, IFNB1
23glycogen43 249.8VIM, S100B, SYP, MYC, PTPRC, GFAP
24dopamine43 28 24 1211.7SYP, IFNB1, S100B, MYCN, GFAP
25cytarabine43 49 1210.6VIM, TP53, MYC, IFNB1, GFAP
26vincristine43 49 1210.6MYCN, TP53, MYC, IFNB1, VIM
27retinoid438.5MYC, MYCN, VIM, TP53, IFNB1
28doxorubicin43 49 1210.5MYCN, MYC, IFNB1, VIM, TP53
29actinomycin d438.5MYC, IFNB1, TP53, VIM, MYCN
30genistein43 28 59 2 24 1213.4GFAP, PTPRC, VIM, MYCN, MYC, IFNB1
31creatinine438.3S100B, GFAP, VIM, IFNB1, SYP
32methionine438.3S100B, GFAP, PTPRC, VIM, IFNB1, RASSF1
33alanine438.2RASSF1, GFAP, IFNB1, MYC, VIM, S100B
34dexamethasone43 49 28 1211.2VIM, S100B, SYP, GFAP, IFNB1, MYC
355-aza-2deoxycytidine438.2RASSF1, TP53, IFNB1, MYC, VIM
36paclitaxel43 49 1210.2MYC, TP53, IFNB1, S100B, GFAP, VIM
37threonine438.2GFAP, S100B, RASSF1, IFNB1, MYC, PTPRC
38cysteine438.2PTPRC, VIM, IFNB1, SYP, S100B, GFAP
39thymidine43 249.1MYC, GFAP, TP53, IFNB1, S100B
40etoposide43 49 59 1210.9VIM, MYCN, MYC, IFNB1, SYP, S100B
41cycloheximide437.9GFAP, IFNB1, MYC, MYCN, VIM, PTPRC
42tyrosine437.9IFNB1, MYCN, MYC, PTPRC, SYP, EWSR1
43cisplatin43 49 59 1210.8MYCN, TP53, IFNB1, RASSF1, GFAP, MYC
44progesterone43 28 59 24 1211.7SYP, IFNB1, VIM, TP53, PTPRC, S100B
45oligonucleotide437.6TP53, MYCN, VIM, EWSR1, MYC, IFNB1
46vegf437.1S100B, SYP, IFNB1, MYC, MYCN, VIM
47estrogen436.8MYC, S100B, PTPRC, GFAP, TP53, VIM
48paraffin436.8VIM, PTPRC, CD99, S100B, SYP, MYC
49retinoic acid43 247.7RASSF1, SYP, IFNB1, MYC, S100B, MYCN
50serine436.2EWSR1, GFAP, PTPRC, VIM, MYCN, MYC

GO Terms for genes affiliated with Neuroectodermal Tumor

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Cellular components related to Neuroectodermal Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:00432348.7TP53, MYC, SYP
2cytoplasmGO:00057377.1EWSR1, GFAP, TP53, VIM, RASSF1, S100B

Biological processes related to Neuroectodermal Tumor according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:006002010.2VIM, GFAP
2astrocyte developmentGO:001400210.1VIM, GFAP
3intermediate filament organizationGO:004510910.1VIM, GFAP
4regulation of neuronal synaptic plasticityGO:004816810.0SYP, S100B
5long-term synaptic potentiationGO:006029110.0GFAP, S100B
6positive regulation of mesenchymal cell proliferationGO:00020539.9MYC, MYCN
7negative regulation of neuron projection developmentGO:00109779.9GFAP, VIM
8negative regulation of reactive oxygen species metabolic processGO:020003789.6MYCN, TP53
9B cell proliferationGO:00421009.6PTPRC, IFNB1
10negative regulation of fibroblast proliferationGO:00481479.5MYC, TP53
11response to gamma radiationGO:00103329.5MYC, TP53
12cellular response to UVGO:00346449.3MYC, TP53
13cell cycle arrestGO:00070509.0RASSF1, MYC, TP53
14cellular response to DNA damage stimulusGO:00069748.9RASSF1, MYC, TP53
15positive regulation of transcription from RNA polymerase II promoterGO:00459448.2TP53, MYCN, MYC, IFNB1

Molecular functions related to Neuroectodermal Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:00428027.3EWSR1, TP53, VIM, SYP, RASSF1, S100B
2protein bindingGO:00055156.9EWSR1, PTPRC, TP53, VIM, MYCN, MYC

Products for genes affiliated with Neuroectodermal Tumor

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Sources for Neuroectodermal Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet