MCID: NRC020
MIFTS: 59

Neuroectodermal Tumor malady

Cancer diseases, Neuronal diseases categories
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Summaries for Neuroectodermal Tumor

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Wikipedia:65 A neuroectodermal tumor is a tumor of the central or peripheral nervous system. more...

MalaCards based summary: Neuroectodermal Tumor, also known as primitive neuroectodermal neoplasm, is related to melanotic neuroectodermal tumor and peripheral primitive neuroectodermal tumor. An important gene associated with Neuroectodermal Tumor is GFAP (glial fibrillary acidic protein), and among its related pathways are Notch Pathway and Nuclear signaling by ERBB4. The compounds eosin and mucicarmine have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and uterus, and related mouse phenotypes are muscle and behavior/neurological.

Aliases & Classifications for Neuroectodermal Tumor

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Sources:
8Disease Ontology, 62UMLS, 44Novoseek, 34MeSH, 57SNOMED-CT, 39NCIt
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Neuroectodermal Tumor, Aliases & Descriptions:

Name: Neuroectodermal Tumor 8 62
Primitive Neuroectodermal Neoplasm 8 62
 
Neuroectodermal Tumors 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:171
MeSH34 D017599
SNOMED-CT57 73676002, 253096008
NCIt39 C3716

Related Diseases for Neuroectodermal Tumor

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Diseases related to Neuroectodermal Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 213)
idRelated DiseaseScoreTop Affiliating Genes
1melanotic neuroectodermal tumor32.5SYP
2peripheral primitive neuroectodermal tumor32.1CD99, EWSR1
3cerebral primitive neuroectodermal tumor31.7MYCN, MYC
4pineoblastoma31.2GFAP, SYP
5neuroepithelioma31.1EWSR1, MYC, MYCN
6rhabdoid tumor31.1VIM, SYP, PTPRC
7childhood medulloblastoma31.1MYCN, MYC
8teratoma31.1GFAP, CD99
9extraosseous ewing's sarcoma31.1CD99, EWSR1
10fibrous histiocytoma31.0EWSR1
11neuroblastoma30.9SYP, MYC, MYCN, TP53
12sarcoma30.8EWSR1, S100B, MYCN, TP53, PTPRC, VIM
13gliosarcoma30.8GFAP
14synovial sarcoma30.7EWSR1, CD99
15ganglioglioma30.6S100B, GFAP, SYP
16olfactory neuroblastoma30.6S100B, CD99, SYP
17embryonal rhabdomyosarcoma30.5EWSR1, PTPRC, MYCN
18clear cell sarcoma30.5EWSR1, S100B
19meningioma30.4VIM, SYP, S100B, GFAP
20lymphoblastic lymphoma30.4CD99, PTPRC
21gastrointestinal stromal tumor30.4VIM, S100B
22paraganglioma30.4GFAP, SYP, S100B
23neurofibroma30.3SYP, S100B, VIM
24stomach cancer30.0TP53, RASSF1, MYC
25ependymoma30.0GFAP, S100B, RASSF1, SYP, VIM
26medulloblastoma30.0TP53, MYCN, MYC, IFNB1, SYP, RASSF1
27osteosarcoma30.0MYC, IFNB1, TP53, MYCN
28malignant glioma29.9IFNB1, TP53, GFAP, SYP
29glioblastoma29.7TP53, GFAP, MYCN, MYC, RASSF1, S100B
30retinoblastoma29.7GFAP, RASSF1, SYP, MYCN, MYC, TP53
31rhabdomyosarcoma29.7PTPRC, TP53, MYCN, VIM, EWSR1, S100B
32wilms tumor29.5PTPRC, VIM, MYCN, RASSF1, EWSR1
33leukemia29.5IFNB1, TP53, CD99, MYC, MYCN, PTPRC
34astrocytoma29.3S100B, SYP, IFNB1, VIM, TP53, GFAP
35breast cancer29.2IFNB1, MYC, MYCN, TP53, RASSF1
36melanoma28.3EWSR1, S100B, RASSF1, PTPRC, TP53, IFNB1
37supratentorial primitive neuroectodermal tumor10.9
38cerebritis10.7
39giant cell glioblastoma10.6GFAP
40dysembryoplastic neuroepithelial tumor10.6SYP
41mixed glioma10.5GFAP
42neurilemmoma10.5GFAP
43gliomatosis cerebri10.5GFAP
44central nervous system primitive neuroectodermal neoplasm10.5
45atypical teratoid rhabdoid tumor10.4
46binswanger's disease10.4SYP, GFAP
47rhabdoid meningioma10.4VIM, GFAP
48astroblastoma10.4VIM, GFAP
49central neurocytoma10.4SYP, GFAP
50secondary progressive multiple sclerosis10.4IFNB1

Graphical network of the top 20 diseases related to Neuroectodermal Tumor:



Diseases related to neuroectodermal tumor

Symptoms for Neuroectodermal Tumor

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Drugs & Therapeutics for Neuroectodermal Tumor

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Drug clinical trials:

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Search NIH Clinical Center for Neuroectodermal Tumor

Genetic Tests for Neuroectodermal Tumor

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Anatomical Context for Neuroectodermal Tumor

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MalaCards organs/tissues related to Neuroectodermal Tumor:

32
Kidney, Bone, Uterus, Brain, Breast, Ovary, Adrenal gland, Spinal cord, Cervix, Pancreas, Liver, Lung, Thyroid, Prostate, Testis, Pineal, Bone marrow, Lymph node, Thymus, Testes, T cells, Cortex, Cerebellum, Retina, Heart, Colon, Skin, Myeloid, B lymphoblasts

Animal Models for Neuroectodermal Tumor or affiliated genes

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MGI Mouse Phenotypes related to Neuroectodermal Tumor:

36 (show all 15)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3TP53, GFAP, MYC, MYCN, VIM, EWSR1
2MP:00053868.0TP53, VIM, MYCN, MYC, S100B, GFAP
3MP:00053818.0PTPRC, TP53, MYCN, MYC, GFAP
4MP:00030128.0MYCN, PTPRC, TP53, SYP, IFNB1, MYC
5MP:00053907.8IFNB1, EWSR1, PTPRC, TP53, MYCN, MYC
6MP:00053857.7RASSF1, MYC, MYCN, VIM, TP53, GFAP
7MP:00020067.7EWSR1, RASSF1, IFNB1, TP53, PTPRC, MYC
8MP:00053787.6MYC, MYCN, VIM, TP53, PTPRC, GFAP
9MP:00053977.5IFNB1, PTPRC, TP53, VIM, EWSR1, MYCN
10MP:00036317.4MYC, SYP, IFNB1, MYCN, VIM, TP53
11MP:00053847.3TP53, MYC, EWSR1, GFAP, PTPRC, VIM
12MP:00107687.1RASSF1, EWSR1, GFAP, PTPRC, TP53, VIM
13MP:00053877.0EWSR1, GFAP, PTPRC, TP53, VIM, RASSF1
14MP:00053767.0MYC, RASSF1, GFAP, MYCN, VIM, PTPRC
15MP:00028736.4GFAP, EWSR1, PTPRC, MYCN, MYC, IFNB1

Publications for Neuroectodermal Tumor

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Articles related to Neuroectodermal Tumor:

(show top 50)    (show all 849)
idTitleAuthorsYear
1
Primitive neuroectodermal tumor with kidney involvement: a case report. (25035703)
2014
2
Melanotic neuroectodermal tumor of infancy disseminated by a ventriculoperitoneal shunt and diagnosed from the inguinal sac. (23823108)
2014
3
Acute transient parotitis in a child with primitive neuroectodermal tumor after a standard dose etoposide. (25006307)
2014
4
Conservative multimodal management of a primitive neuroectodermal tumor of the thyroid. (23888220)
2013
5
Rare pulmonary primitive neuroectodermal tumor metastasizing to the right atrium: a case report. (22392199)
2012
6
Low-grade bone lesions in survivors of childhood medulloblastoma/primitive neuroectodermal tumor. (22054800)
2012
7
Primitive neuroectodermal tumor/Ewing's sarcoma of the urinary bladder: a case report and its molecular diagnosis. (21063743)
2011
8
Primary primitive neuroectodermal tumor of the urinary bladder: a case report and literature review. (20852971)
2011
9
Paravaginal peripheral primitive neuroectodermal tumor: A rare tumor. (22557788)
2011
10
Melanotic neuroectodermal tumor of infancy in oral cavity at unusual age. (20704481)
2010
11
Primitive neuroectodermal tumors in patients with testicular germ cell tumors usually resemble pediatric-type central nervous system embryonal neoplasms and lack chromosome 22 rearrangements. (20348883)
2010
12
Inferior vena cava thrombus in renal primitive neuroectodermal tumor is not rare. (20690331)
2010
13
Primary vulvar Ewing's sarcoma/primitive neuroectodermal tumor in a post-menopausal woman: a case report. (19656640)
2010
14
Uterine primitive neuroectodermal tumor: a case report. (18523790)
2009
15
Dumbbell-shaped peripheral primitive neuroectodermal tumor of the spine--case report and review of the literature. (19050994)
2009
16
Uncommon pleural effusion: pleuropulmonary metastasis from primitive neuroectodermal tumor. (19618040)
2009
17
Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases. (18452568)
2009
18
Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation. (19390556)
2009
19
Melanotic neuroectodermal tumor of infancy: a case report. (18704448)
2008
20
Primary primitive neuroectodermal tumor of the uterus: a case report. (17823807)
2008
21
Primitive neuroectodermal tumor of the kidney confirmed by fluorescence in situ hybridization. (17366107)
2007
22
Primitive neuroectodermal tumor arising in a testicular teratoma with retroperitoneal metastasis: report of an interesting case with review of literature. (17991577)
2007
23
Neonatal macrocephaly: cerebral primitive neuroectodermal tumor or neuroblastoma as an infrequent cause--a case report and review of the literature. (17909991)
2007
24
A phase II study of the farnesyl transferase inhibitor, tipifarnib, in children with recurrent or progressive high-grade glioma, medulloblastoma/primitive neuroectodermal tumor, or brainstem glioma: a Children's Oncology Group study. (17932894)
2007
25
Quantitative mRNA expression analysis of neurotrophin-receptor TrkC and oncogene c-MYC from formalin-fixed, paraffin-embedded primitive neuroectodermal tumor samples. (17080715)
2006
26
Untreated pediatric primitive neuroectodermal tumor in vivo: quantitation of taurine with MR spectroscopy. (16118174)
2005
27
Somatostatin receptor subtype 2 is expressed by supratentorial primitive neuroectodermal tumors of childhood and can be targeted for somatostatin receptor imaging. (15131035)
2004
28
Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. (12594313)
2003
29
Primitive neuroectodermal tumor of the cervix: a clinicopathologic and immunohistochemical study of two cases. (12376920)
2002
30
Extraaxial primitive neuroectodermal tumor mimicking a vestibular schwannoma: diagnostic and therapeutic difficulties. Report of two cases. (11302660)
2001
31
Role of MAP kinase pathways in primitive neuroectodermal tumors. (11724348)
2001
32
Intense p53 staining is a valuable prognostic indicator for poor prognosis in medulloblastoma/central nervous system primitive neuroectodermal tumors. (11451203)
2001
33
Melanotic Neuroectodermal Tumor of Infancy: Clinicopathologic Study of a Case, with Emphasis on the Chemotherapeutic Effects. (11493999)
2000
34
Molecular biology of the Ewing's sarcoma/primitive neuroectodermal tumor family. (10623711)
2000
35
Primary primitive neuroectodermal tumor of the cauda equina. (10987262)
2000
36
Bone morphogenetic proteins-2 and -4 attenuate apoptosis in a cerebellar primitive neuroectodermal tumor cell line. (10336254)
1999
37
Documentation of EWS gene rearrangements by fluorescence in-situ hybridization (FISH) in frozen sections of Ewing's sarcoma-peripheral primitive neuroectodermal tumor. (10078922)
1999
38
The Ewing tumor family of peripheral primitive neuroectodermal tumors expresses human gastrin-releasing peptide. (9622091)
1998
39
Centrosome amplification as a possible mechanism for numerical chromosome aberrations in cerebral primitive neuroectodermal tumors with TP53 mutations. (10072601)
1998
40
Brief report. Melanotic neuroectodermal tumor of infancy located in the skull. (9835920)
1998
41
Primitive neuroectodermal tumor of the cervix uteri. A case report. (9065588)
1997
42
Renal primitive neuroectodermal tumor: a morphologic, cytogenetic, and molecular analysis with the establishment of two cultured cell lines. (9559290)
1997
43
Melanotic neuroectodermal tumor of infancy in the epididymis. Case report and literature review. (8961502)
1996
44
Malignant peripheral neuroectodermal tumors in urology. (8528296)
1995
45
TGF beta 1 and TGF beta 2 are potential growth regulators for medulloblastomas, primitive neuroectodermal tumors, and ependymomas: evidence in support of an autocrine hypothesis. (8200640)
1994
46
Secretogranin II expression in Ewing's sarcomas and primitive neuroectodermal tumors. (1342962)
1992
47
Ultrastructural characteristics of a cell line derived from a melanotic neuroectodermal tumor of infancy. (1648614)
1991
48
Overexpression of the pseudoautosomal gene MIC2 in Ewing's sarcoma and peripheral primitive neuroectodermal tumor. (1695726)
1990
49
Melanotic neuroectodermal tumor of infancy. (2856802)
1986
50
Melanotic neuroectodermal tumor of infancy: its histological similarities to fetal pineal gland. (851944)
1977

Variations for Neuroectodermal Tumor

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Expression for genes affiliated with Neuroectodermal Tumor

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Expression patterns in normal tissues for genes affiliated with Neuroectodermal Tumor

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Pathways for genes affiliated with Neuroectodermal Tumor

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Compounds for genes affiliated with Neuroectodermal Tumor

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Compounds related to Neuroectodermal Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1eosin449.8VIM, GFAP, S100B
2mucicarmine449.7VIM, S100B, SYP
3s 100449.6VIM, SYP, GFAP, S100B
4reticulin449.6S100B, VIM, SYP, GFAP
5catecholamine449.4MYCN, SYP, S100B, VIM
6ganglioside449.4GFAP, PTPRC, VIM, SYP
7b 723449.3S100B, SYP, VIM, PTPRC
8hmba449.3MYC, MYCN, TP53
9choline44 24 1111.2VIM, SYP, S100B, GFAP
10agarose449.1PTPRC, MYCN, MYC, S100B
11hematoxylin449.1S100B, GFAP, VIM, SYP, PTPRC
12formaldehyde44 2410.1VIM, PTPRC, GFAP, SYP, S100B
13temozolomide44 1110.0IFNB1, TP53, VIM
14agar449.0RASSF1, VIM, GFAP, MYC, MYCN
15adriamycin449.0VIM, TP53, MYCN, MYC
16chloramphenicol44 2 50 1112.0IFNB1, S100B, MYCN, VIM, MYC
17glutamine448.9EWSR1, S100B, SYP, GFAP, VIM
18leucine448.9GFAP, MYCN, MYC, SYP, S100B, VIM
19acth448.9S100B, GFAP, PTPRC, SYP, IFNB1
20iron44 249.8MYCN, S100B, IFNB1, VIM, GFAP
21bromodeoxyuridine448.8S100B, GFAP, VIM, MYCN, MYC, IFNB1
22dbc-amp448.8GFAP, VIM, MYCN, S100B, SYP, IFNB1
23glycogen44 249.8VIM, S100B, SYP, MYC, PTPRC, GFAP
24dopamine44 28 24 1111.7SYP, IFNB1, S100B, MYCN, GFAP
25cytarabine44 50 1110.6VIM, TP53, MYC, IFNB1, GFAP
26vincristine44 50 1110.6MYCN, TP53, MYC, IFNB1, VIM
27retinoid448.5MYC, MYCN, VIM, TP53, IFNB1
28doxorubicin44 50 1110.5MYCN, MYC, IFNB1, VIM, TP53
29actinomycin d448.5MYC, IFNB1, TP53, VIM, MYCN
30genistein44 28 61 2 24 1113.4GFAP, PTPRC, VIM, MYCN, MYC, IFNB1
31creatinine448.3S100B, GFAP, VIM, IFNB1, SYP
32methionine448.3S100B, GFAP, PTPRC, VIM, IFNB1, RASSF1
33alanine448.2RASSF1, GFAP, IFNB1, MYC, VIM, S100B
34dexamethasone44 50 28 1111.2VIM, S100B, SYP, GFAP, IFNB1, MYC
355-aza-2deoxycytidine448.2RASSF1, TP53, IFNB1, MYC, VIM
36paclitaxel44 50 1110.2MYC, TP53, IFNB1, S100B, GFAP, VIM
37threonine448.2GFAP, S100B, RASSF1, IFNB1, MYC, PTPRC
38cysteine448.2PTPRC, VIM, IFNB1, SYP, S100B, GFAP
39thymidine44 249.1MYC, GFAP, TP53, IFNB1, S100B
40etoposide44 50 61 1110.9VIM, MYCN, MYC, IFNB1, SYP, S100B
41cycloheximide447.9GFAP, IFNB1, MYC, MYCN, VIM, PTPRC
42tyrosine447.9IFNB1, MYCN, MYC, PTPRC, SYP, EWSR1
43cisplatin44 50 61 1110.8MYCN, TP53, IFNB1, RASSF1, GFAP, MYC
44progesterone44 28 61 24 1111.7SYP, IFNB1, VIM, TP53, PTPRC, S100B
45oligonucleotide447.6TP53, MYCN, VIM, EWSR1, MYC, IFNB1
46vegf447.1S100B, SYP, IFNB1, MYC, MYCN, VIM
47estrogen446.8MYC, S100B, PTPRC, GFAP, TP53, VIM
48paraffin446.8VIM, PTPRC, CD99, S100B, SYP, MYC
49retinoic acid44 247.7RASSF1, SYP, IFNB1, MYC, S100B, MYCN
50serine446.2EWSR1, GFAP, PTPRC, VIM, MYCN, MYC

GO Terms for genes affiliated with Neuroectodermal Tumor

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Cellular components related to Neuroectodermal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.7TP53, MYC, SYP
2cytoplasmGO:0057377.1EWSR1, GFAP, TP53, VIM, RASSF1, S100B

Biological processes related to Neuroectodermal Tumor according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:06002010.2VIM, GFAP
2astrocyte developmentGO:01400210.1VIM, GFAP
3intermediate filament organizationGO:04510910.1VIM, GFAP
4regulation of neuronal synaptic plasticityGO:04816810.0SYP, S100B
5long-term synaptic potentiationGO:06029110.0GFAP, S100B
6positive regulation of mesenchymal cell proliferationGO:0020539.9MYC, MYCN
7negative regulation of neuron projection developmentGO:0109779.9GFAP, VIM
8negative regulation of reactive oxygen species metabolic processGO:20003789.6MYCN, TP53
9B cell proliferationGO:0421009.6PTPRC, IFNB1
10negative regulation of fibroblast proliferationGO:0481479.5MYC, TP53
11response to gamma radiationGO:0103329.5MYC, TP53
12cellular response to UVGO:0346449.3MYC, TP53
13cell cycle arrestGO:0070509.0RASSF1, MYC, TP53
14cellular response to DNA damage stimulusGO:0069748.9RASSF1, MYC, TP53
15positive regulation of transcription from RNA polymerase II promoterGO:0459448.2TP53, MYCN, MYC, IFNB1

Molecular functions related to Neuroectodermal Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:0428027.3S100B, RASSF1, SYP, VIM, TP53, EWSR1
2protein bindingGO:0055156.9PTPRC, TP53, VIM, MYCN, MYC, RASSF1

Products for genes affiliated with Neuroectodermal Tumor

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Sources for Neuroectodermal Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet