Neuroectodermal Tumors malady

Wikipedia: A neuroectodermal tumor is a tumor of the central or peripheral nervous system.⁴⁴ more...

MalaCards: Neuroectodermal Tumors, also known as neuroectodermal tumor, is related to supratentorial primitive neuroectodermal tumor and melanotic neuroectodermal tumor. An important gene associated with Neuroectodermal Tumors is MYC (v-myc myelocytomatosis viral oncogene homolog (avian)), and among its related pathways are Colorectal cancer and Pancreatic cancer. The compounds choline and agar have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and liver, and related mouse phenotypes are liver/biliary system and respiratory system.

neuroectodermal tumors 7 32 43 neuroectodermal tumor 8

Diseases related to neuroectodermal tumors by text searches and GeneDecks gene sharing:

(show top 50)    (show all 883)

id	Related Disease	Score	Top Affiliating Genes
1	supratentorial primitive neuroectodermal tumor	36.0	MYC, MYCN, MYB, RASSF1, S100B, MPRIP
2	melanotic neuroectodermal tumor	35.1	VIM, MYOG, MFI2, APBA3, MBP, ENO2
3	peripheral primitive neuroectodermal tumor	34.9	KIT, KITLG, RB1, PARP1, BCL2, BCL2L1
4	cerebral primitive neuroectodermal tumor	34.9	MYC, MYCN, S100B, MSH2, IFNB1, TP53
5	ewing's family of tumors	33.0	NCAM1, VIM, MYC, MYCN, CHGA, CDK4
6	atypical teratoid rhabdoid tumor	31.6	VIM, RASSF1, MUC1, IGF1R, TP53, SMARCB1
7	rhabdoid tumors	31.4	VIM, MUC1, IGF1R, PTPRC, SMARCB1, WT1
8	pineoblastoma	31.3	CADPS, TP53, GFAP, SYP
9	extraosseous ewing's sarcoma	31.3	S100B, CD99, EWSR1, ETV4
10	medulloblastoma	31.1	NCAM1, KIT, RB1, SERPINF1, VIM, VIP
11	neuroepithelioma	31.0	NCAM1, KITLG, MYC, MYCN, CD99, FLI1
12	lymphoblastic lymphoma	30.1	VIP, CD99, FLI1, ENO2, PTPRC, NOTCH1
13	askin's tumor	30.1	S100B, ENO2, NTRK1, NGF
14	olfactory neuroblastoma	30.0	VIM, S100B, CDKN1A, EWSR1, NTRK1, NTRK2
15	synovial sarcoma	29.9	KIT, VIM, MYCN, RASSF1, BCL2, MUC1
16	childhood medulloblastoma	29.4	MYC, CDKN2A, APC, CADPS, PTCH1, PTPRC
17	leydig cell tumor	29.2	KIT, VIM, MYOG, MUC1, APC, ENO2
18	ependymoma	29.1	NCAM1, RB1, VIM, RASSF1, MUC1, S100B
19	basal cell carcinoma	28.6	MYCN, BMP2, BCL2, BCL2L1, MUC1, S100B
20	sarcoma	28.0	NCAM1, KIT, KITLG, RB1, VIM, VIP
21	vaginitis	27.8	KIT, VIM, VIP, VIPR1, PARP1, BCL2
22	wilms tumor	27.6	NCAM1, SERPINF1, VIM, MYC, MYCN, MYOG
23	cerebritis	26.5	NCAM1, KITLG, VIM, VIP, VIPR1, MYC
24	astrocytoma	26.3	NCAM1, KIT, RB1, VIM, MYC, RAF1
25	retinoblastoma	25.2	NCAM1, KIT, KITLG, RB1, SERPINF1, VIM
26	soft tissue sarcoma	25.0	KIT, KITLG, RB1, VIM, MYC, MYOG
27	duodenitis	24.5	KIT, KITLG, VIP, MYCN, PAX4, BCL2
28	malignant glioma	23.9	KIT, KITLG, RB1, VIM, MYC, RAF1
29	neuroblastoma	23.1	NCAM1, KIT, KITLG, RB1, SERPINF1, VIM
30	hypoxia	21.8	KIT, KITLG, RB1, SERPINF1, VIP, MYC
31	pancreatitis	18.9	NCAM1, KIT, KITLG, RB1, SERPINF1, VIM
32	prostatitis	18.7	NCAM1, KIT, KITLG, RB1, SERPINF1, VIM
33	carcinoma	18.2	NCAM1, KIT, KITLG, RB1, SERPINF1, VIM
34	neuronitis	17.2	NCAM1, KIT, KITLG, RB1, SERPINF1, VIM
35	esthesioneuroblastoma	14.4	S100B, CD99, ASCL1, FLI1, ENO2, SSTR2
36	hemangioblastoma	14.3	NCAM1, VIM, KDR, MUC1, S100A1, S100B
37	giant cell glioblastoma	14.3	VIM, S100B, MDM2, TP53, PTEN, GFAP
38	ganglioglioma	14.3	MYCN, BCL2L1, CHGA, S100B, ENO2, TP53
39	chordoid glioma	14.3	VIM, MUC1, S100B, CDK4, GFAP, SYP
40	neuroendocrine carcinoma	14.3	NCAM1, KIT, SCG2, CHGA, MUC1, S100B
41	dysembryoplastic neuroepithelial tumor	14.3	BCL2L1, CHGA, S100B, TP53, GFAP, SYP
42	glomus tumor	14.3	VIM, MUC1, S100A1, S100B, NGFR, SYP
43	chordoid meningioma	14.3	NCAM1, VIM, MUC1, S100B, GFAP
44	myoepithelioma	14.3	KITLG, VIM, S100A1, S100B, EWSR1, TP53
45	ganglioneuroblastoma	14.3	VIP, MYCN, CHGA, S100B, MBP, ENO2
46	myxopapillary ependymoma	14.3	NCAM1, VIM, MUC1, S100B, GFAP
47	mediastinitis	14.2	KIT, VIM, MYC, MYB, S100A1, ENO2
48	pulmonary sclerosing hemangioma	14.2	MYC, CHGA, MUC1, ENO2, SYNM, SYP
49	mixed cell type cancer	14.2	VIM, ENO2, TP53, GFAP, DES
50	granulosa cell tumor of the ovary	14.2	VIM, CHGA, ENO2, TP53, SYP

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to neuroectodermal tumors:

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MGI Mouse Phenotypes related to neuroectodermal tumors:

²⁵ (show all 28)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	10.3	KIT, MYCN, MYB, ATF4, ASAH1, IRS1
2	respiratory system phenotype	MP:0005388	9.9	MYCN, MYOG, PAX7, PAX3, ASCL1, CADPS
3	renal/urinary system phenotype	MP:0005367	9.1	KIT, MYCN, PAX3, BCL2, CHGA, CDKN1A
4	pigmentation phenotype	MP:0001186	9.0	KIT, KITLG, RB1, SERPINF1, MYC, PAX3
5	limbs/digits/tail phenotype	MP:0005371	9.0	KIT, KITLG, RB1, MYCN, BMP2, PAX3
6	craniofacial phenotype	MP:0005382	8.4	KIT, KITLG, MYCN, PAX7, PAX3, ATF4
7	adipose tissue phenotype	MP:0005375	8.4	RB1, VIPR2, MYC, MYOG, BCL2, XDH
8	digestive/alimentary phenotype	MP:0005381	8.4	KIT, KITLG, RB1, SERPINF1, VIPR1, MYC
9	no phenotypic analysis	MP:0003012	8.3	RB1, MYC, PAX7, PARP1, PAX3, MUC1
10	hearing/vestibular/ear phenotype	MP:0005377	8.3	KIT, KITLG, RB1, MYC, BMP2, PARP1
11	vision/eye phenotype	MP:0005391	7.9	NCAM1, KIT, KITLG, RB1, SERPINF1, VIM
12	endocrine/exocrine gland phenotype	MP:0005379	7.9	VIPR1, PAX7, PAX3, XDH, ATF3, FUS
13	muscle phenotype	MP:0005369	7.8	KIT, RB1, VIM, MYC, MYCN, MYOG
14	normal phenotype	MP:0002873	7.5	VIP, MYC, MYOG, MYB, BMP2, PAX7
15	tumorigenesis	MP:0002006	7.4	KIT, KITLG, RB1, MYC, RASSF1, PAX7
16	reproductive system phenotype	MP:0005389	7.2	SERPINF1, VIP, VIPR2, MYCN, BMP2, PAX3
17	hematopoietic system phenotype	MP:0005397	7.1	KIT, MYCN, PAX3, BCL2, BCL2L1, XRCC5
18	skeleton phenotype	MP:0005390	6.7	KIT, KITLG, RB1, MYC, MYCN, MYOG
19	embryogenesis phenotype	MP:0005380	6.6	KIT, VIM, MYC, MYCN, MYOG, MYB
20	integument phenotype	MP:0010771	6.6	KIT, KITLG, RB1, MYC, MYOG, MYB
21	cardiovascular system phenotype	MP:0005385	6.5	KIT, KITLG, RB1, SERPINF1, VIM, VIPR1
22	immune system phenotype	MP:0005387	6.1	KIT, VIM, VIPR2, MYB, RAF1, PAX7
23	nervous system phenotype	MP:0003631	6.1	KIT, KITLG, RB1, SERPINF1, MYC, MYCN
24	behavior/neurological phenotype	MP:0005386	5.6	NCAM1, KIT, RB1, VIM, VIP, VIPR1
25	mortality/aging	MP:0010768	4.9	NCAM1, KITLG, RB1, VIPR1, MYCN, MYOG
26	homeostasis/metabolism phenotype	MP:0005376	4.4	KIT, KITLG, RB1, VIM, VIP, VIPR1
27	cellular phenotype	MP:0005384	3.7	NCAM1, KIT, KITLG, RB1, VIM, VIPR1
28	growth/size phenotype	MP:0005378	3.5	KIT, KITLG, RB1, VIPR1, VIPR2, MYC

Articles related to neuroectodermal tumors:

(show top 50)    (show all 157)

id	Title	Authors	Year	Affiliating Genes
1	Primitive neuroectodermal tumor of the liver: a case report. (19995788)	Mani S.... De B.K.	2010	SYP
2	Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases. (18452568)	Perry A.... Rosenblum M.K.	2009	MYC
3	p18Ink4c and p53 Act as tumor suppressors in cyclin D1-driven primitive neuroectodermal tumor. (19147556)	Saab R.... Skapek S.X.	2009	CDK4
4	Cerebral primitive neuroectodermal tumor in an adult with a heterozygous MSH2 mutation. (19390556)	Jeans A.F.... Ansorge O.	2009	MSH2
5	Superficial primitive neuroectodermal tumor/Ewing sarcoma (PN/ES): same tumor as deep PN/ES or new entity? (17498589)	Ehrig T.... Fanburg-Smith J.C.	2007	DNTT
6	High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumors. (16783165)	McCabe M.G.... Collins V.P.	2006	PDGFRA, MYB
7	A general aspect on soft-tissue sarcoma and c-kit expression in primitive neuroectodermal tumor and Ewing's sarcoma. Is there any role in disease process? (16127511)	Kara I.O.... Erdogan S.	2005	KITLG
8	Clinicopathological study of Ewing's sarcoma/primitive neuroectodermal tumor in oral and maxillofacial region (16255919)	He H.W.... He Z.X.	2005	CD99, S100A1, SYNM
9	Establishment and characterization of new cell lines derived from melanotic neuroectodermal tumor of infancy arising in the mandible. (15943790)	Metwaly H.... Saku T.	2005	MBP
10	Primitive neuroectodermal tumor of the gallbladder. (15086299)	Song D.E.... Ro J.Y.	2004	PTPRC, S100B, DES
11	Supratentorial primitive neuroectodermal tumor: report of a surgical case (15352632)	Omae T.... Mizoi K.	2004	GFAP, CD99
12	Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators. (15289350)	Batra S.... Maurer B.J.	2004	ASAH1, ASAH2
13	Novel germ-line deletion of SNF5/INI1/SMARCB1 gene in neonate presenting with congenital malignant rhabdoid tumor of kidney and brain primitive neuroectodermal tumor. (15101046)	Kusafuka T.... Fukuzawa M.	2004	SMARCB1
14	Targeted delivery of oncogene-selective antisense oligonucleotides in neuroectodermal tumors: therapeutic implications. (15650235)	Pastorino F.... Ponzoni M.	2004	MYC, MYB
15	Primary primitive peripheral neuroectodermal tumor of the prostate. Immunophenotypic and molecular study of a case. (12683899)	Colecchia M.... Pilotti S.	2003	SYP
16	Primary Ewing's sarcoma/primitive neuroectodermal tumor of the kidney: a clinicopathologic and immunohistochemical analysis of 11 cases. (11859203)	Jimenez R.E.... Amin M.B.	2002	FLI1
17	Overexpression of cyclooxygenase-2 (COX-2) in human primitive neuroectodermal tumors: effect of celecoxib and rofecoxib. (11911965)	Patti R.... Reddy C.D.	2002	BCL2, CASP3, PTGS2
18	Cytogenetic and histopathologic studies of congenital supratentorial primitive neuroectodermal tumors: a case report. (11349224)	Girschick H.J.... KA1hl J.	2001	MYCN
19	MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma. (11489822)	Grotzer M.A.... Phillips P.C.	2001	MYC
20	Establishment of human neuroectodermal tumor cell line (PFSK) with stable expression of xanthine oxidoreductase (12549228)	Liu X.... Xu P.	2001	XDH
21	Insulin production in a neuroectodermal tumor that expresses islet factor-1, but not pancreatic-duodenal homeobox 1. (11297620)	Nakamura T.... Kikkawa R.	2001	PAX4, NEUROG3
22	Immunohistology of neuroendocrine and neuroectodermal tumors. (10968705)	Wick M.R.	2000	B3GAT1
23	Cerebral primitive neuroectodermal tumor in an adult male. A case report. (11127734)	Masuda K.... Nagata I.	2000	S100B
24	Lovastatin induces apoptosis in a primitive neuroectodermal tumor cell line in association with RB down-regulation and loss of the G1 checkpoint. (11146561)	Kim J.S.... Trepel J.B.	2000	RB1
25	Peripheral primitive neuroectodermal tumor of the small bowel mesentery: a case showing perforation at onset. (10849329)	Horie Y.... Kato M.	2000	CD99
26	Interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-1 receptor type I, IL-1 receptor antagonist, and TGF-beta 1 mRNAs in pediatric astrocytomas, ependymomas, and primitive neuroectodermal tumors. (9565970)	Ilyin S.E.... Plata-Salaman C.R.	1998	IL1B, IL1A, IL1RAPL2
27	Peripheral primitive neuroectodermal tumors in adults: documentation by molecular analysis. (9508202)	Lawlor E.R.... Sorensen P.H.	1998	EWSR1, ETV7
28	Mutant p53 may selectively suppress glial specific proteins in pluripotential human neuroectodermal tumor cells. (9578140)	U H.S.... Chen J.	1998	GLUL, GFAP
29	Betulinic acid triggers CD95 (APO-1/Fas)- and p53-ind ependent apoptosis via activation of caspases in neuroectodermal tumors. (9354463)	Fulda S.... Debatin K.M.	1997	BCL2, PARP1, CASP8
30	Renal primitive neuroectodermal tumor: a morphologic, cytogenetic, and molecular analysis with the establishment of two cultured cell lines. (9559290)	Takeuchi T.... Kikuchi M.	1997	EWSR1
31	p21 (WAF1/Cip1/Sdi1/Pic1) mRNA is expressed in neuroblastoma cell lines but not in Ewing's sarcoma and primitive neuroectodermal tumor cell lines. (9363658)	Maeda T.... Sano K.	1997	CDKN1A
32	Expression of neurogenic basic helix-loop-helix genes in primitive neuroectodermal tumors. (9270024)	Rostomily R.C.... Olson J.M.	1997	NEUROD1, NEUROD2, NEUROG1
33	Chromosome arm 17p deletion analysis reveals molecular genetic heterogeneity in supratentorial and infratentorial primitive neuroectodermal tumors of the central nervous system. (9242214)	Burnett M.E.... Cogen P.H.	1997	TP53
34	Neurotrophin and neurotrophin receptor proteins in medulloblastomas and other primitive neuroectodermal tumors of the pediatric central nervous system. (8774147)	Washiyama K.... Trojanowski J.Q.	1996	NTRK1, NTRK2, NTRK3
35	Two primitive neuroectodermal tumor cell lines require an activated insulin-like growth factor I receptor for growth in vitro. (8938773)	Chin L.S.... Raffel C.	1996	IGF1
36	Peripheral neuroepithelioma (peripheral primitive neuroectodermal tumor) of the uterine cervix. (9111767)	Sato S.... Sakuma H.	1996	ENO2
37	Olfactory neuroblastoma is a peripheral primitive neuroectodermal tumor related to Ewing sarcoma. (8577710)	Sorensen P.H.... Triche T.J.	1996	EWSR1
38	Primitive neuroectodermal tumor of the myocardium: a case report, review of the literature, immunohistochemical, and ultrastructural study. (8958313)	Charney D.A.... Teplitz C.	1996	ENO2
39	Melanotic neuroectodermal tumor of infancy: a molecular approach to diagnosis. Case report. (7782833)	Nitta T.... Sato K.	1995	MFI2
40	EWS-FLI-1 and EWS-ERG chimeric mRNAs in Ewing's sarcoma and primitive neuroectodermal tumor. (7591257)	Ida K.... Hayashi Y.	1995	ERG
41	Human interferon-beta therapy for cerebral primitive neuroectodermal tumors--two case reports. (7753313)	Tanaka S.... Nagashima T.	1995	IFNB1
42	Expression of synaptophysin and neurofilament protein confirms predominantly neuroblastic differentiation of primitive neuroectodermal tumors (PNET). (7780694)	Papierz W.... Liberski P.P.	1995	SYP
43	Expression of nerve growth factor receptor by human primitive neuroectodermal tumors. (7526237)	Kokunai T.... Tamaki N.	1994	NGFR
44	Expression of N-myc, c-myc and c-erbB-1 proto-oncogenes in cerebral primitive neuroectodermal tumors (PNET). (7889335)	Debiec-Rychter M.... Liberski P.P.	1994	MYC, MYCN
45	Secretogranin II expression in Ewing's sarcomas and primitive neuroectodermal tumors. (1342962)	Pagani A.... Bussolati G.	1992	CHGA, CHGB, SCG2
46	Immunohistochemistry of primitive neuroectodermal tumors in infants with special emphasis on cytokeratin expression. (1723829)	Grieshammer T.... Vogeley K.T.	1991	KRT18, KRT8, KRT13
47	MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. (1848471)	Ambros I.M.... Salzer-Kuntschik M.	1991	CD99
48	Antiserum from a patient with cerebellar degeneration identifies a novel protein in Purkinje cells, cortical neurons, and neuroectodermal tumors. (1851215)	Darnell R.B.... Posner J.B.	1991	AP3B2
49	Establishment and characterization of a primitive neuroectodermal tumor of bone continuous cell line (LAP-35). (2177080)	Bagnara G.P.... Pession A.	1990	MR1
50	Immunophenotype profile of childhood medulloblastomas and supratentorial primitive neuroectodermal tumors using 16 monoclonal antibodies. (2196109)	Zeltzer P.M.... Kemshead J.	1990	PTPRC

Genes related to neuroectodermal tumors according to GeneCards:

(show top 50)    (show all 156)

id	Symbol	Description	Score	GeneCards Section Context
1	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.0	Publications
2	MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	11.0	Publications
3	GFAP	glial fibrillary acidic protein	11.0	Publications
4	EWSR1	Ewing sarcoma breakpoint region 1	11.0	Publications
5	SYP	synaptophysin	11.0	Publications
6	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
7	CD99	CD99 molecule	11.0	Publications
8	FLI1	Friend leukemia virus integration 1	11.0	Publications
9	ETV7	ets variant 7	11.0	Publications
10	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0	Publications
11	SSTR2	somatostatin receptor 2	11.0	Publications
12	MYB	v-myb myeloblastosis viral oncogene homolog (avian)	11.0	Publications
13	VIM	vimentin	11.0	Publications
14	PTPRC	protein tyrosine phosphatase, receptor type, C	11.0	Publications
15	S100B	S100 calcium binding protein B	11.0	Publications
16	GRP	gastrin-releasing peptide	11.0	Publications
17	IFNB1	interferon, beta 1, fibroblast	11.0	Publications
18	CSF3	colony stimulating factor 3 (granulocyte)	11.0	Publications
19	TP53	tumor protein p53	11.0	Publications
20	NCAM1	neural cell adhesion molecule 1	11.0	Publications
21	PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	11.0	Summaries
22	SLITRK3	SLIT and NTRK-like family, member 3	11.0	Expressions
23	SLITRK5	SLIT and NTRK-like family, member 5	11.0
24	SLITRK2	SLIT and NTRK-like family, member 2	11.0	Expressions
25	SLITRK4	SLIT and NTRK-like family, member 4	11.0	Expressions
26	SLITRK6	SLIT and NTRK-like family, member 6	11.0	Expressions
27	COLQ	collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase	11.0
28	IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	11.0	Publications
29	NES	nestin	11.0	Publications
30	DMBT1	deleted in malignant brain tumors 1	11.0	Publications
31	TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa	11.0
32	ATF1	activating transcription factor 1	11.0
33	NGFR	nerve growth factor receptor	11.0	Publications
34	ETV1	ets variant 1	11.0
35	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications
36	PTCH1	patched 1	11.0	Publications
37	PRMT8	protein arginine methyltransferase 8	11.0
38	DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	11.0	Publications
39	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
40	DES	desmin	11.0	Publications
41	TNC	tenascin C	11.0
42	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
43	CDK4	cyclin-dependent kinase 4	11.0	Publications
44	TH	tyrosine hydroxylase	11.0	Publications
45	ERG	v-ets erythroblastosis virus E26 oncogene homolog (avian)	11.0	Publications
46	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
47	PTEN	phosphatase and tensin homolog	11.0	Publications
48	MUC1	mucin 1, cell surface associated	11.0	Publications
49	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	11.0	Publications
50	NGF	nerve growth factor (beta polypeptide)	11.0	Publications

Pathways related to neuroectodermal tumors according to GeneDecks:

(show top 50)    (show all 223)

id	Pathway	Score	Top Affiliating Genes
1	Colorectal cancer20	10.8	MSH2, AKT3, TGFB2
2	Pancreatic cancer20	10.7	AKT3
3	Signal transduction_PTEN pathway41	10.7	IRS1, IGF1R
4	Bladder cancer20	10.5	KRAS, MYC, RAF1, TP53, MAPK3, MDM2
5	Glioblastoma Multiforme36	10.5	RB1, RAF1, PTEN, TP53, AKT3, IGF1R
6	PTEN Pathway36	10.4	PDGFRA, PTEN, NTF3, TNC, KDR, IGF1R
7	Development Neurotrophin family signaling10	10.4	RAF1, NGFR, AKT3, TP53, MAPK3, MAPK10
8	Development_Neurotrophin family signaling41	10.4	MAPK10, AKT3, TP53, NTF3, NTRK1, NTRK3
9	Melanoma20	10.4	PTEN, PDGFRA, KRAS, TP53, AKT3, IGF1
10	Chronic myeloid leukemia20	10.4	MYC, RB1, CDK4, MDM2, MAPK3, AKT3
11	Glioma20	10.4	IGF1, IGF1R, MAPK3, MDM2, CDK4, CDKN2A
12	Neuroscience3	10.3	NGF, TFAP2A, NGFR, NTRK2, TH, NEUROD1
13	Signal transduction PTEN pathway10	10.3	CASP3, PTEN, AKT3, IGF1, IGF1R, IRS1
14	Apoptotic Pathways in Synovial Fibroblasts36	10.2	CASP8, NTRK2, TGFB2, PDGFRA, NGFR, IGF1R
15	Telomerase Components in Cell Signaling36	10.2	BMP2, KDR, MYC, PDGFRA, NGFR, NTF3
16	Endothelin-1 Signaling Pathway36	10.2	KIT, MYC, BMP2, RAF1, IL1A, CSF3
17	Neurotrophin signaling pathway20	10.2	NGF, RAF1, ATF4, MAPK3, MAPK10, AKT3
18	Prostate cancer20	10.2	PDGFRA, BCL2, ATF4, TP53, MAPK3, IGF1R
19	PPAR Pathway36	10.1	KIT, IGF1, KITLG, PDGFRA, NGFR, NTRK3
20	ERK Signaling36	10.1	IGF1R, ATF1, TGFB2, PDGFRA, PPP1R15A, ATF4
21	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.1	AKT3, BCL2, CYCS, NTRK1, NGF
22	14-3-3 Induced Intracellular Signaling36	10.0	KITLG, BMP2, RAF1, MAPK3, IGF1R, PDGFRA
23	Breast Cancer Regulation by Stathmin136	10.0	TGFB2, NTF3, BMP2, RAF1, MAPK10, CCNB3
24	MAPK signaling pathway20	9.9	TP53, RAF1, ATF4, IL1A, NGF, IL1B
25	JAK-STAT Pathway36	9.9	STAT3, TGFB2, PDGFRA, MAPK3, NGFR, NTRK3
26	p70S6K Signaling36	9.9	NTRK1, IGF1R, NTF3, NTRK2, NTRK3, NGFR
27	ILK Signaling36	9.8	NTRK1, NTRK2, NTRK3, PDGFRA, KRT18, TGFB2
28	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	9.8	AKT3, TP53, CYCS, NTRK1, NGF, CASP3
29	Renin-Angiotensin Pathway36	9.8	BMP2, RAF1, KDR, MAPK10, IGF1R, IGF1
30	Estrogen Pathway36	9.7	TGFB2, KIT, KITLG, BMP2, RAF1, KDR
31	eIF2 Pathway36	9.6	PDGFRA, EIF2AK3, EIF2S1, TGFB2, IGF1, KIT
32	Akt Signaling36	9.6	TNF, NTF3, NTRK3, NGFR, PDGFRA, TGFB2
33	Pathways in cancer20	9.6	CYCS, CDK4, STAT3, KRAS, SMO, CASP8
34	MAPK Signaling36	9.6	KITLG, TNC, MYC, IGF1, TP53, TNF
35	Apoptosis20	9.6	CASP3, NGF, BCL2, BCL2L1, IL1A, IL1B
36	Activation of PKA through GPCR36	9.5	IGF1R, MAPK3, ATF4, KDR, RAF1, BMP2
37	p53 Mediated Apoptosis36	9.5	TP53, KIT, KITLG, BMP2, AKT3, CASP8
38	Pancreatic Adenocarcinoma36	9.5	KDR, RAF1, BMP2, RB1, KITLG, KIT
39	p53 signaling pathway20	9.4	CASP3, CASP8, CDKN1A, CCNB3, IGF1, MDM2
40	Mitochondrial Apoptosis36	9.4	TGFB2, PDGFRA, NGFR, NTRK3, NTRK2, NTRK1
41	Cellular Apoptosis Pathway36	9.4	KITLG, TNF, CYCS, NTF3, NTRK1, NTRK2
42	DHA Signaling36	9.2	KIT, AKT3, CYCS, NTF3, NTRK1, NTRK2
43	Ceramide Pathway36	9.2	TNF, RAF1, ATF3, ATF1, ATF4, MAPK3
44	Molecular Mechanisms of Cancer36	9.2	RB1, MYC, BMP2, RAF1, KDR, BCL2
45	Rho Family GTPases36	9.1	NTRK1, CSF3, TNF, TNC, NTRK2, NTRK3
46	p38 Signaling36	9.1	KITLG, KDR, TP53, CASP3, IGF1, IGF1R
47	PAK Pathway36	9.1	NTRK1, NTRK3, NTRK2, BCL2, KDR, BMP2
48	Apoptosis and survival Caspase cascade10	8.9	CASP3, PARP1, IGF1R, IGF1, CYCS, TNF
49	Antioxidant Action of Vitamin-C36	8.8	KITLG, NTF3, NTRK2, NTRK3, NGFR, PDGFRA
50	Apoptosis and survival_Caspase cascade41	8.7	TNF, IGF1R, CASP8, CASP3, IGF1, AKT3

Compounds related to neuroectodermal tumors according to GeneDecks:

(show top 50)    (show all 378)

id	Compound	Score	Top Affiliating Genes
1	choline32 9 18 9	13.8	VIM, VIP, MYB, RAF1, S100B, GRP
2	agar32	10.4	KITLG, RB1, VIM, MYCN, RASSF1, MUC1
3	gaba32 42	11.3	NCAM1, VIM, VIP, CHGA, S100B, GRP
4	adenylate32	10.2	KITLG, VIM, VIP, VIPR1, VIPR2, MYOG
5	matrigel32	10.2	NCAM1, RB1, SERPINF1, VIM, BMP2, KDR
6	dopamine32 9 18 9	13.2	NCAM1, VIP, MYCN, BMP2, RAF1, SCG2
7	formaldehyde32 18	11.1	KIT, RB1, VIM, CHGA, MUC1, S100B
8	glycogen32 18	11.1	KIT, VIM, MYC, CHGA, S100A1, S100B
9	sp 60012532 42	11.0	CDKN1A, CASP3, TP53, CYCS
10	pge232	9.8	VIP, BMP2, RAF1, ATF1, GRP, IL1A
11	phosphotyrosine32	9.7	KIT, RAF1, KDR, CDK4, IRS1, MBP
12	paraffin32	9.7	NCAM1, KIT, KITLG, RB1, VIM, MYC
13	creatinine32	9.6	NCAM1, KITLG, MYOG, BMP2, CHGA, MUC1
14	glucose32	9.5	KIT, SERPINF1, VIPR1, MYOG, PAX4, SCG2
15	tamoxifen32 34 9 9	12.3	VIM, MYC, RAF1, KDR, BCL2, CHGA
16	ceramide32	9.2	RB1, RAF1, BCL2L1, CDK4, ASAH1, ASAH2
17	forskolin32 42 9 9	12.2	VIM, VIP, VIPR1, MYOG, BMP2, RAF1
18	cytarabine32 34 9 9	12.2	KIT, KITLG, RB1, VIM, MYC, BCL2
19	histamine32 18	10.2	NCAM1, KIT, KITLG, VIM, VIP, RAF1
20	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	9.1	MYC, PARP1, BCL2, BCL2L1, S100B, IL1A
21	wortmannin32 42	10.0	KITLG, VIM, BMP2, RAF1, KDR, BCL2
22	5fluorouracil32	9.0	KIT, KITLG, RB1, KDR, BCL2, BCL2L1
23	c2ceramide32	9.0	MYOG, PARP1, BCL2L1, IRS1, IL1B, CASP3
24	estrogen32	9.0	VIP, MYOG, BMP2, RAF1, RASSF1, KDR
25	calcium32 9 18 9	11.9	KIT, KITLG, RB1, SERPINF1, VIP, VIPR1
26	calcitriol32 42 9 18 9	12.9	KITLG, RB1, MYC, BMP2, CDKN1A, CDK4
27	norepinephrine32 9 18 9	11.9	KITLG, VIP, SCG2, CHGB, CHGA, S100B
28	nitric oxide32 9 18 9	11.8	NCAM1, KIT, KITLG, RB1, SERPINF1, VIPR1
29	flavopiridol32 9 9	10.8	KIT, RB1, PARP1, BCL2, BCL2L1, CDKN1A
30	sb 20358032 42	9.7	RB1, VIM, BMP2, PARP1, BCL2, BCL2L1
31	alanine32	8.7	NCAM1, KITLG, VIP, VIPR1, MYC, MYB
32	12-o-tetradecanoylphorbol 13-acetate32	8.6	NCAM1, RB1, MYC, MYOG, RAF1, SCG2
33	genistein32 9 18 9	11.3	KITLG, RB1, VIM, MYC, MYCN, BMP2
34	lipid32	8.3	NCAM1, KITLG, RB1, VIM, VIPR1, MYOG
35	thymidine32 18	9.3	KIT, KITLG, RB1, VIP, MYC, MYB
36	glutamine32	8.3	NCAM1, KIT, VIM, VIP, MYB, RAF1
37	arsenite32 18	9.3	MYC, PARP1, BCL2, BCL2L1, ATF4, CDKN1A
38	arginine32	8.2	VIP, MYB, BMP2, CHGA, B3GAT1, S100B
39	carboplatin32 34 9 9	11.1	KITLG, RB1, PARP1, KDR, BCL2, CHGA
40	thapsigargin32 42	9.0	VIP, MYB, RAF1, BCL2, BCL2L1, ATF1
41	superoxide32 18	9.0	KITLG, RB1, SCG2, XDH, CDK4, IL1B
42	butyrate32	8.0	KITLG, RB1, VIM, MYC, MYOG, MYB
43	curcumin32	8.0	MYC, RAF1, PARP1, BCL2, BCL2L1, CDKN1A
44	lactate32	7.6	NCAM1, KIT, KITLG, VIM, VIP, MYCN
45	oxygen32 18	8.6	KITLG, RB1, SERPINF1, MYOG, MYB, BMP2
46	pd 98,05932	7.5	KIT, KITLG, RB1, MYC, MYOG, BMP2
47	actinomycin d32	6.8	KIT, KITLG, RB1, VIM, VIPR1, MYC
48	cisplatin32 34 9 9	9.5	KITLG, RB1, MYC, MYCN, RAF1, RASSF1
49	cysteine32	6.4	SERPINF1, MYOG, MYB, RAF1, PARP1, PAX3
50	retinoic acid32 42 18	8.3	NCAM1, KIT, KITLG, RB1, SERPINF1, VIPR1

Cellular components related to neuroectodermal tumors according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:005882	10.5	NES, DES, SYNM, KRT18, KRT8, VIM
2	protein complex	GO:043234	9.3	S100A1, BMP2, MYC, MDM2, ALB, STXBP1
3	extracellular space	GO:005615	8.7	SCG2, CSF3, CSF2, TGFB2, NGF, SPARC
4	extracellular region	GO:005576	8.3	NCAM1, KITLG, IL1B, IGLC7, IGF1, IFNB1
5	nucleoplasm	GO:005654	8.0	TP53, CASP3, MAPK10, MAPK3, SMARCA5, NOTCH1
6	cytosol	GO:005829	7.7	MDM2, BCL2, APC, MCF2, MAPK3, MAPK10
7	nucleolus	GO:005730	7.2	STAT3, CASP3, CASP8, ETV4, AKT3, TP53
8	cytoplasm	GO:005737	7.1	CDKN2A, IRS1, FLII, MDM2, AP3B2, APC
9	nucleus	GO:005634	4.6	SMARCA5, PAX3, KDR, BCL2, XRCC5, S100A1

Biological processes related to neuroectodermal tumors according to GeneDecks:

(show top 50)    (show all 72)

id	Name	GO ID	Score	Top Affiliating Genes
1	axonogenesis	GO:007409	11.0	APC, S100B, SLITRK4, SLITRK6, SLITRK2, SLITRK1
2	positive regulation of fibroblast proliferation	GO:048146	10.7	CDK4, CDKN1A, PDGFRA, NGFR, IGF1, MYC
3	response to gamma radiation	GO:010332	10.7	TP53, PTPRC, IL1B, BCL2, IL1A, MYC
4	phosphatidylinositol-mediated signaling	GO:048015	10.7	IGF1, NGF, PDGFRA, IGF1R, MDM2, IRS1
5	response to wounding	GO:009611	10.6	CASP3, GFAP, SMO, NGFR, TNC, TGFB2
6	response to L-ascorbic acid	GO:033591	10.6	BCL2, IL1A, IL1B, SPARC
7	release of cytochrome c from mitochondria	GO:001836	10.6	MYC, CASP3, BCL2, TP53, BCL2L1
8	cell cycle arrest	GO:007050	10.6	CDKN2A, RASSF1, CDKN1A, TGFB2, PPP1R15A, MYC
9	central nervous system development	GO:007417	10.5	NES, NGFR, PTEN, TP53, MBP, S100B
10	positive regulation of neuron differentiation	GO:045666	10.5	BMP2, ASCL1, NEUROD1, NEUROD2, NEUROG1, NEUROG2
11	MAPK cascade	GO:000165	10.5	KRAS, NF1, TNF, IL1B, SCG2, RAF1
12	virus-host interaction	GO:019048	10.5	DMBT1, PDGFRA, RB1, CASP8, VIM, KDR
13	response to drug	GO:042493	10.5	BCL2, PAX4, MYC, TGFB2, CDK4, NES
14	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.5	NTRK1, TNF, MAPK3, IL1B, IL1A, KDR
15	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.4	TGFB2, PDGFRA, NTRK2, IGF1, KIT, KDR
16	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	10.4	NEUROG3, SMARCB1, IL1B, TNF, PTEN, SMARCA4
17	response to radiation	GO:009314	10.4	KIT, NGF, TGFB2, BCL2, KRT13
18	positive regulation of apoptotic process	GO:043065	10.4	TGFB2, IL1B, NEUROD1, BMP2, APC, TP53
19	response to glucocorticoid stimulus	GO:051384	10.4	SPARC, PTGS2, TNF, IL1B, SERPINF1, NGF
20	response to DNA damage stimulus	GO:006974	10.4	RASSF1, TP53, CASP3, MYC, MAPK3, APC
21	response to estradiol stimulus	GO:032355	10.4	CASP8, IL1B, ENO2, PTGS2, STAT3, TGFB2
22	response to hypoxia	GO:001666	10.3	TH, TGFB2, BMP2, NF1, CRYAB, TNF
23	response to organic cyclic compound	GO:014070	10.3	STAT3, ENO2, IL1A, ATF1, CDKN1A, MSH2
24	Ras protein signal transduction	GO:007265	10.3	RASSF1, NF1, NGF, NTRK1, TP53, IGF1
25	negative regulation of neuron apoptotic process	GO:043524	10.3	NGF, STXBP1, NTRK1, NTF3, MSH2, BCL2L1
26	organ morphogenesis	GO:009887	10.3	ETV7, PAX4, PAX3, BCL2, FLI1, TH
27	chromatin remodeling	GO:006338	10.3	SMARCA4, SMARCA5, RB1, MYC, SMARCB1, MYB
28	peripheral nervous system development	GO:007422	10.3	SOX10, NTF3, NGF, NF1, NEUROG3
29	nerve growth factor receptor signaling pathway	GO:048011	10.3	STAT3, NTRK1, PTEN, CASP3, MCF2, NTRK2
30	positive regulation of neuron apoptotic process	GO:043525	10.3	CASP3, TGFB2, NF1, TNF, ASCL1, TFAP2A
31	cell fate commitment	GO:045165	10.3	KDR, NEUROG1, BMP2, NEUROG2, CASP3
32	wound healing	GO:042060	10.2	IL1B, NF1, PDGFRA, TGFB2, IL1A, RAF1
33	anti-apoptosis	GO:006916	10.1	BCL2L1, IL1A, NGFR, NGF, CRYAB, TNF
34	insulin-like growth factor receptor signaling pathway	GO:048009	10.1	IRS1, IGF1, IGF1R, EIF2AK3
35	cell proliferation	GO:008283	10.0	STAT3, RAF1, BCL2L1, XRCC5, S100B, MIA
36	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	10.0	XDH, TNF, CDKN2A, IFNB1, CASP8, EIF2AK3
37	negative regulation of cell growth	GO:030308	10.0	TGFB2, BCL2, CDKN1A, CDKN2A, TP53, SMARCA4
38	heart development	GO:007507	10.0	RAF1, NF1, TH, TGFB2, BMP2, SPARC
39	induction of apoptosis by intracellular signals	GO:008629	10.0	MYC, CDKN1A, CASP8, BCL2L1, BCL2, CASP3
40	response to organic nitrogen	GO:010243	9.8	IL1B, TGFB2, CDKN1A, IL1A, PTGS2
41	positive regulation of DNA replication	GO:045740	9.8	KITLG, ATF1, IGF1R, CSF2, PDGFRA, IGF1
42	negative regulation of cell proliferation	GO:008285	9.5	IGF1, BMP2, RAF1, CDKN1A, TFAP2A, TGFB2
43	positive regulation of gene expression	GO:010628	9.4	TFAP2A, TGFB2, KRAS, NGF, SMO, NTRK2
44	positive regulation of cell proliferation	GO:008284	9.4	IGF1, IGF1R, IRS1, CDK4, ATF3, KDR
45	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.4	S100A1, BMP2, PAX4, PARP1, MDM2, ID1
46	negative regulation of transcription, DNA-dependent	GO:045892	9.1	SMARCA4, TP53, EZH2, ID1, ASCL1, ATF3
47	positive regulation of transcription, DNA-dependent	GO:045893	9.1	ETV4, ETV1, IGF1, IL1B, CDKN2A, ATF4
48	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.1	NEUROG3, BMP2, TP53, SMO, NOTCH1, IL1B
49	apoptotic process	GO:006915	9.0	DICER1, ASAH2, BCL2, DSG2, NGFR, NGF
50	negative regulation of apoptotic process	GO:043066	7.9	CDKN1A, ASCL1, MDM2, APC, IGF1R, ALB

Molecular functions related to neuroectodermal tumors according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	E-box binding	GO:070888	10.6	NEUROG1, MYC, MYOG, ASCL1, NEUROG2, NEUROD1
2	protein heterodimerization activity	GO:046982	10.5	MYC, MYOG, NEUROD1, PRMT8, TGFB2, TP53
3	neurotrophin binding	GO:043121	10.4	NTRK1, NTRK3, NTRK2
4	p53 binding	GO:002039	10.3	SMARCB1, SMARCA4, CDKN2A, MUC1, MDM2
5	transmembrane receptor protein tyrosine kinase activity	GO:004714	10.2	KDR, NTRK1, NTRK3, KIT, PDGFRA
6	nerve growth factor binding	GO:048406	10.1	NGFR, NTF3, NTRK1
7	protein kinase binding	GO:019901	10.0	PTEN, MSH2, APC, BCL2L1, VIM, STAT3
8	double-stranded DNA binding	GO:003690	9.7	PAX4, WT1, XRCC5, NEUROG3, NEUROD1, ASCL1
9	identical protein binding	GO:042802	9.7	GLUL, CASP8, TNF, EIF2AK3, SYP, STXBP1
10	cytokine activity	GO:005125	9.6	KITLG, IL1B, TNF, TGFB2, CSF2, BMP2
11	protein homodimerization activity	GO:042803	9.6	IDH1, XDH, S100B, S100A1, BCL2, MSH2
12	growth factor activity	GO:008083	9.4	BMP2, KITLG, MIA, IL1B, IGF1, NTF3
13	sequence-specific DNA binding transcription factor activity	GO:003700	8.8	TP53, ATF3, NEUROD1, SOX1, STAT3, WT1
14	sequence-specific DNA binding	GO:043565	8.2	ETV1, ATF1, MYC, PAX7, PAX4, PAX3
15	protein binding	GO:005515	3.1	VIM, S100B, MSH2, ATF3, ATF4, FUS