MCID: NRN001
MIFTS: 55

Neuroendocrine Carcinoma malady

Neuronal, Cancer categories

Summaries for Neuroendocrine Carcinoma

Sources:
8Disease Ontology, 33MalaCards
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Disease Ontology:8 A carcinoma that derives from neuroendocrine cells.

MalaCards: Neuroendocrine Carcinoma, also known as carcinoma, neuroendocrine, is related to large cell carcinoma and adenocarcinoma. An important gene associated with Neuroendocrine Carcinoma is GPR112 (G protein-coupled receptor 112), and among its related pathways are Cytoskeletal Signaling and Cytoskeleton remodeling Keratin filaments. The compounds paraffin and progesterone have been mentioned in the context of this disorder. Affiliated tissues include lymph node, thymus and brain, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Aliases & Classifications for Neuroendocrine Carcinoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Aliases & Descriptions:

neuroendocrine carcinoma 8 10
carcinoma, neuroendocrine 61
carcinoma neuroendocrine 45


External Ids:

Disease Ontology8 DOID:1800
MeSH35 D018278
SNOMED-CT57 253000007, 55937004
NCIt40 C3773

Related Diseases for Neuroendocrine Carcinoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1large cell carcinoma31.6TP63, ENO2, KRT20, KRT7, CHGA, SYP
2adenocarcinoma31.2KRT19, CDKN2A, CHGA, SYP, NKX2-1, KRT18
3merkel cell carcinoma31.0NKX2-1, SYP, CHGA, KRT20, KRT8, ENO2
4bladder carcinoma31.0CDKN2A, KRT19, KRT18, KRT20, KRT8, TP63
5thymic carcinoma30.8NKX2-1, SYP, KRT18, KRT7, TP63
6squamous cell carcinoma30.6CHGA, CDKN2A, KRT19, KRT18, KRT7, KRT20
7basal cell carcinoma30.5KRT19, KRT7, KRT20, KRT8, TP63, TP53
8teratoma30.4NKX2-1, KRT7, ENO2
9adenoma30.4KRT19, CDKN2A, CHGA, SYP, NKX2-1, KRT18
10thyroid medullary carcinoma30.4NKX2-1, CHGA, ENO2, ASCL1
11papillary carcinoma30.2KRT20, TP63, KRT7, KRT18, NKX2-1, SYP
12adenosquamous carcinoma30.2TP63, KRT8, KRT20, KRT7, KRT19, CHGA
13tubular adenocarcinoma30.2SYP, CHGA, KRT7, KRT20, ENO2, TP63
14cystadenoma30.2KRT7
15carcinoid syndrome29.9NKX2-1, SYP, CHGA, KRT20, KRT8, ENO2
16paraganglioma29.9ENO2, CHGA, SYP
17thymoma29.9TP63, NKX2-1
18barrett's esophagus29.9TP53, KRT20, KRT7, CDKN2A
19ulcerative colitis29.9TP53
20sertoli cell tumor29.9ENO2, SYP
21bladder adenocarcinoma29.9KRT7, KRT20
22gastrointestinal stromal tumor29.9ENO2
23olfactory neuroblastoma29.9SYP, ENO2
24small cell carcinoma11.0
25n syndrome10.7
26cutaneous neuroendocrine carcinoma10.7
27cervix small cell carcinoma10.6
28thymic neuroendocrine carcinoma10.6
29cushing's syndrome10.5
30lung combined large cell neuroendocrine carcinoma10.4
31prostate small cell carcinoma10.4
32urinary bladder small cell neuroendocrine carcinoma10.4
33ovarian large-cell neuroendocrine carcinoma10.4
34breast large cell neuroendocrine carcinoma10.4
35cervical large cell neuroendocrine carcinoma10.3
36thymus large cell carcinoma10.3
37adrenal carcinoma10.3
38bile duct carcinoma10.3
39spindle cell carcinoma10.2
40mucinous adenocarcinoma10.2
41lambert syndrome10.2
42neuroendocrine carcinoma of the cervix10.2
43multiple endocrine neoplasia10.2
44pancreatic endocrine carcinoma10.1
45basaloid lung carcinoma10.1
46atrophic gastritis10.1
47esophagus small cell carcinoma10.1
48colon small cell carcinoma10.1
49lung giant cell carcinoma10.1
50anal canal carcinoma10.1

Graphical network of the top 20 diseases related to Neuroendocrine Carcinoma:



Diseases related to neuroendocrine carcinoma

Clinical Features for Neuroendocrine Carcinoma

Drugs & Therapeutics for Neuroendocrine Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Neuroendocrine Carcinoma

Drug clinical trials:

Search ClinicalTrials for Neuroendocrine Carcinoma

Search NIH Clinical Center for Neuroendocrine Carcinoma

Search CenterWatch for Neuroendocrine Carcinoma

Genetic Tests for Neuroendocrine Carcinoma

Anatomical Context for Neuroendocrine Carcinoma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Neuroendocrine Carcinoma:

33
Lymph node, Thymus, Brain, Heart, Skeletal muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Ovary, Prostate, Testis, Cervix, T cells, B cells, Endothelial, Fetal brain, Tongue, Fetal liver, Fetal lung, Appendix, Fetal thyroid, Pancreatic islet, Pituitary

Animal Models for Neuroendocrine Carcinoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Neuroendocrine Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.7TP53, NKX2-1, CHGA, CDKN2A, VGF, KRT19
2MP:001076810.6VGF, CDKN2A, NGB, CHGA, KRT19, KRT18
3MP:000301210.6NKX2-1, SYP, NGB, CDKN2A, KRT19, ASCL1
4MP:000538910.4CDKN2A, VGF, KRT19, TP53
5MP:000537810.3NKX2-1, CHGA, CDKN2A, VGF, KRT19, KRT18

Publications for Neuroendocrine Carcinoma

Sources:
51PubMed
See all sources

Articles related to Neuroendocrine Carcinoma:

(show top 50)    (show all 897)
idTitleAuthorsYear
1
Metastatic small cell neuroendocrine carcinoma of the pelvic floor. (24065309)
2013
2
Treatment of poorly differentiated neuroendocrine carcinoma of the pancreas. (23846932)
2013
3
Advanced composite of large cell neuroendocrine carcinoma and squamous cell carcinoma: a case report of uterine cervical cancer in a virgin woman. (24062959)
2013
4
Large cell neuroendocrine carcinoma presenting with neck swelling in the submandibular gland: a case report. (23509998)
2013
5
Large-cell neuroendocrine carcinoma of lung with epidermal growth factor receptor (EGFR) gene mutation and co-expression of adenocarcinoma markers: a case report and review of the literature. (23866929)
2013
6
Surgery for Giant Primary Neuroendocrine Carcinoma of the Liver. (24146337)
2013
7
Primary Combined Neuroendocrine and Squamous Cell Carcinoma of the Maxillary Sinus: Report of a Case with Immunohistochemical and Molecular Characterization. (24327102)
2013
8
Primary hepatic neuroendocrine carcinoma: MR imaging findings including preliminary observation on diffusion-weighted imaging. (23942951)
2013
9
Combination chemotherapy with irinotecan and cisplatin for large-cell neuroendocrine carcinoma of the lung: a multicenter phase II study. (23774385)
2013
10
Small cell neuroendocrine carcinoma of the paranasal sinus. (24163566)
2013
11
Primary treatment and prognostic factors of small cell neuroendocrine carcinoma of the uterine cervix: a Taiwanese Gynecologic Oncology Group study. (22244826)
2012
12
Mixed endocervical adenocarcinoma and high-grade neuroendocrine carcinoma of the cervix with ovarian metastasis of the former component: a report of 2 cases. (22833092)
2012
13
Small cell carcinoma of the urinary bladder: a rare, aggressive neuroendocrine malignancy. (23106592)
2012
14
Solid papillary carcinoma of the breast with neuroendocrine features in a pregnant woman: a case report. (21876491)
2011
15
Chromogranin A measurement in metastatic well-differentiated gastroenteropancreatic neuroendocrine carcinoma: screening for false positives and a prospective follow-up study. (21574156)
2011
16
Large cell neuroendocrine carcinoma of the endometrium: an extremely uncommon diagnosis, but worth the efforts. (21768718)
2011
17
Large cell neuroendocrine carcinoma of the cervix: prognostic factors and survival advantage with platinum chemotherapy. (21138780)
2011
18
Large-cell neuroendocrine carcinoma: controversies in diagnosis and treatment. (21975912)
2011
19
Primary neuroendocrine carcinoma of breast. (21713100)
2011
20
ERCC1 and Ki67 in small cell lung carcinoma and other neuroendocrine tumors of the lung: distribution and impact on survival. (20104194)
2010
21
Cancer-associated retinopathy in neuroendocrine carcinoma of the fallopian tube. (20724944)
2010
22
Neuroendocrine small cell carcinoma of the uterine cervix. (20615830)
2010
23
Large cell/neuroendocrine carcinoma. (20133008)
2010
24
Major hyperghrelinemia in advanced well-differentiated neuroendocrine carcinomas: report of three cases. (19605542)
2009
25
Metastatic well-differentiated neuroendocrine carcinoma of the pancreas: case report and review of literature. (19918355)
2009
26
Diffuse cardiac lymphatic involvement by metastatic neuroendocrine carcinoma mimicking hypertrophic cardiomyopathy: a case report. (20062644)
2009
27
Small cell neuroendocrine carcinoma of the cervix: Analysis of outcome, recurrence pattern and the impact of platinum-based combination chemotherapy. (19110302)
2009
28
Genetics of a combined lung small cell carcinoma and large cell neuroendocrine carcinoma with adenocarcinoma. (18551311)
2008
29
Neuroendocrine carcinoma of the ampulla of Vater: a clinicopathologic evaluation. (18693180)
2008
30
Pulmonary large cell neuroendocrine carcinoma: its place in the spectrum of pulmonary carcinoma. (17643676)
2007
31
Primary neuroendocrine carcinoma arising within a mature sacrococcygeal teratoma. (17990418)
2007
32
Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. (16236978)
2005
33
The prognostic role of c-kit protein expression in resected large cell neuroendocrine carcinoma of the lung. (14726070)
2004
34
Thyroid transcription factor-1, but not p53, is helpful in distinguishing moderately differentiated neuroendocrine carcinoma of the larynx from medullary carcinoma of the thyroid. (15098009)
2004
35
Anal canal neuroendocrine carcinoma with Pagetoid extension. (15260855)
2004
36
Small cell neuroendocrine carcinoma of the cervix: outcome and patterns of recurrence. (15047210)
2004
37
Primary small cell neuroendocrine carcinoma of the breast. (15743041)
2004
38
Neuroendocrine tissue-specific transcription factor, BETA2/NeuroD, in gastric carcinomas: a comparison with chromogranin A and synaptophysin expressions. (14533935)
2003
39
Large cell neuroendocrine carcinoma of the cervix associated with adenocarcinoma in situ: evidence of a common origin. (11444207)
2001
40
Development of an ELISA for the detection of serum chromogranin A (CgA) in prostate and non-neuroendocrine carcinomas. (11694235)
2001
41
Cytodiagnosis of bronchogenic carcinoma and neuroendocrine tumor of the lung by transthoracic fine-needle aspiration. (11074654)
2000
42
Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. (10757334)
2000
43
Neuroendocrine differentiation in prostatic carcinoma. (10221570)
1999
44
Malignant Sertoli cell tumor of the ovary metastatic to the lung mimicking neuroendocrine carcinoma: report of a case. (10459047)
1999
45
Liver transplantation for metastatic neuroendocrine carcinoma: an analysis of 103 patients. (9846513)
1998
46
Prognosticating tools in primary neuroendocrine (Merkel-cell) carcinomas of the skin: histopathological subdivision, DNA cytometry, cell proliferation analyses (Ki-67-immunoreactivity) and NCAM immunohistochemistry. A clinicopathological study in 25 patients. (9542743)
1998
47
Neuroendocrine differentiation is a common feature of thymic carcinoma. (9737237)
1998
48
Immunohistochemical study in breast carcinoma. S100-protein positive cells and neuroendocrine differentiation. (9017169)
1996
49
Plasma neuroendocrine markers in patients with benign prostatic hyperplasia and prostatic carcinoma. (8632569)
1996
50
Disseminated strongyloidiasis in a World War II Veteran with metastatic undifferentiated carcinoma of neuroendocrine type. (1329234)
1992

Genetic Variations for Neuroendocrine Carcinoma

Expression for genes affiliated with Neuroendocrine Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Neuroendocrine Carcinoma.

Pathways for genes affiliated with Neuroendocrine Carcinoma

Sources:
4Cell Signaling Technology, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5KRT8, KRT7, KRT18, KRT19
210.5KRT8, KRT7, KRT18, KRT19
310.5TP53, TP63, CDKN2A
410.5KRT19, KRT8, TP53
5
Hide members
10.5TP53, TP63

Compounds for genes affiliated with Neuroendocrine Carcinoma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB
See all sources

Compounds related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1paraffin4511.1TP53, TP63, ENO2, KRT8, KRT20, KRT7
2progesterone45 60 29 11 2415.1NKX2-1, SYP, CHGA, CDKN2A, KRT19, KRT18
3retinoic acid45 2412.1KRT19, CDKN2A, CHGA, SYP, NKX2-1, KRT18
4vegf4511.1KRT19, VGF, CDKN2A, CHGA, SYP, KRT18
5hematoxylin4511.1KRT18, KRT19, CDKN2A, CHGA, SYP, NKX2-1
6tyrosine4511.1NKX2-1, SYP, CHGA, VGF, KRT19, KRT18
7testosterone45 60 11 2414.1SYP, CHGA, CDKN2A, KRT19, KRT18, KRT7
8b 7234511.0TP63, KRT8, KRT20, KRT7, KRT19, CHGA
9formaldehyde45 2412.0NKX2-1, SYP, CHGA, KRT19, KRT18, KRT7
10cisplatin45 50 60 1114.0SYP, CHGA, CDKN2A, KRT19, KRT8, ENO2
11iron45 2412.0LCN1, NGB, CDKN2A, KRT19, KRT18, KRT7
12forskolin45 50 1113.0NKX2-1, SYP, CHGA, VGF, KRT18, KRT8
13glycogen45 2412.0SYP, CHGA, KRT19, KRT18, KRT7, KRT8
14mucicarmine4511.0NKX2-1, SYP, KRT7, KRT20, TP63
15lipid4511.0LCN1, SYP, CHGA, NGB, CDKN2A, KRT18
16bromodeoxyuridine4511.0CHGA, KRT19, KRT18, KRT8, ENO2, TP63
17creatinine4511.0LCN1, SYP, CHGA, CDKN2A, KRT19, KRT18
18sucrose45 11 2413.0SYP, CHGA, KRT19, KRT18, KRT20, KRT8
19steroid4511.0NKX2-1, SYP, CDKN2A, KRT19, KRT18, KRT8
20smcc4511.0SYP, CHGA, KRT19, ENO2
21matrigel4511.0CHGA, KRT19, KRT18, KRT7, KRT8, TP63
22gold4511.0SYP, CHGA, CDKN2A, KRT18, KRT8
23glucose4510.9NGB, CDKN2A, KRT19, KRT18, KRT7, KRT8
24doxorubicin45 50 1112.9CDKN2A, KRT18, KRT20, KRT8, TP63, TP53
25lactate4510.9LCN1, CHGA, KRT19, KRT18, KRT8, ENO2
26s 1004510.9SYP, CHGA, ENO2
27silver4510.9ENO2, CDKN2A, CHGA, SYP
28thymidine45 2411.9TP53, TP63, ENO2, KRT18, KRT19, VGF
29retinoid4510.9KRT19, KRT18, KRT7, KRT8, TP53
30dopamine45 29 11 2413.9CHGA, KRT18, ENO2
31ribonucleic acid4510.9ENO2, KRT20, KRT19, CHGA, NKX2-1
32histidine4510.9SYP, CHGA, NGB, CDKN2A, TP63
33paclitaxel45 50 1112.9TP53, KRT8, KRT19, CDKN2A, CHGA
34etoposide45 50 60 1113.8CHGA, KRT8
35oxygen45 2411.8LCN1, CHGA, NGB, CDKN2A, KRT19, KRT18
36l-amino acid4510.8SYP, CHGA, ENO2
37docetaxel45 50 60 1113.8CDKN2A, KRT18, ENO2, TP53
38adriamycin4510.8KRT8, CDKN2A
39oligonucleotide4510.8NKX2-1, CHGA, CDKN2A, KRT18, KRT8, TP53
40fitc4510.8KRT19, KRT18, KRT8
41hyaluronic acid45 2411.8LCN1, KRT19, KRT20, ENO2
42dutp4510.8TP53, KRT18, SYP
43serine4510.7NKX2-1, SYP, CHGA, CDKN2A, KRT19, KRT18
44methanol45 2411.7KRT7, CDKN2A, CHGA
45dexamethasone45 50 29 1113.7NKX2-1, CDKN2A, KRT18, ENO2
46estracyt4510.6CHGA, ENO2
47dmso4510.5TP63, ENO2, KRT18, CHGA
48metanephrine45 2411.5ENO2, CHGA
49chloride4510.4LCN1, KRT19, KRT8, ENO2
50nitric oxide45 11 2412.3SYP, CHGA, NGB, CDKN2A, KRT18, ENO2

GO Terms for genes affiliated with Neuroendocrine Carcinoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:00573010.6TTF1, PNMA2, KRT18, KRT7, TP63, TP53
2intermediate filamentGO:00588210.5KRT8, KRT20, KRT7, KRT18, KRT19
3nucleoplasmGO:00565410.5NKX2-1, CDKN2A, TTF1, KRT8, TP63, TP53
4keratin filamentGO:04509510.2KRT8, KRT7, KRT18

Biological processes related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1modulation by virus of host morphology or physiologyGO:01904810.7KRT19, KRT18, KRT7, KRT8, TP53
2cerebral cortex GABAergic interneuron differentiationGO:02189210.7ASCL1, NKX2-1
3apoptotic processGO:00691510.6NGB, PNMA2, KRT18, KRT20, KRT8, TP63
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.5TP53, TP63
5cell differentiation involved in embryonic placenta developmentGO:06070610.5KRT8, KRT19
6mitotic G1 DNA damage checkpointGO:03157110.4TP63, TP53
7replicative senescenceGO:09039910.2TP53, CDKN2A

Molecular functions related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00203910.5TP53, TP63, CDKN2A
2MDM2/MDM4 family protein bindingGO:09737110.2TP53, CDKN2A

Products for genes affiliated with Neuroendocrine Carcinoma

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  • Proteins
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Sources for Neuroendocrine Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet