MCID: NRN001
MIFTS: 57

Neuroendocrine Carcinoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Neuroendocrine Carcinoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A carcinoma that derives from neuroendocrine cells.

MalaCards: Neuroendocrine Carcinoma, also known as carcinoma, neuroendocrine, is related to large cell carcinoma and neuroendocrine tumor. An important gene associated with Neuroendocrine Carcinoma is GPR112 (G protein-coupled receptor 112), and among its related pathways are Cytoskeletal Signaling and Cytoskeleton remodeling Keratin filaments. The compounds paraffin and progesterone have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and prostate, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Aliases & Classifications for Neuroendocrine Carcinoma

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroendocrine carcinoma 8
carcinoma, neuroendocrine 60


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Disease Ontology8 DOID:1800
MeSH34 D018278
SNOMED-CT56 253000007, 55937004
NCIt39 C3773

Related Diseases for Neuroendocrine Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 284)
idRelated DiseaseScoreTop Affiliating Genes
1large cell carcinoma31.6TP63, ENO2, KRT20, KRT7, CHGA, SYP
2neuroendocrine tumor31.1SYP, CHGA, KRT19, KRT20, KRT8, ENO2
3adenocarcinoma31.1KRT19, CDKN2A, CHGA, SYP, NKX2-1, KRT18
4pulmonary large cell neuroendocrine carcinoma31.0LCN1
5merkel cell carcinoma30.9NKX2-1, SYP, CHGA, KRT20, KRT8, ENO2
6bladder carcinoma30.9CDKN2A, KRT19, KRT18, KRT20, KRT8, TP63
7lung small cell carcinoma30.9NKX2-1, TP53, TP63, ASCL1, ENO2, KRT8
8hepatitis30.7KRT8
9squamous cell carcinoma30.6CHGA, CDKN2A, KRT19, KRT18, KRT7, KRT20
10lung cancer30.5NKX2-1, CHGA, CDKN2A, KRT19, KRT18, KRT8
11prostate cancer30.4CHGA, KRT18, KRT7, KRT8, ENO2, TP63
12adenoma30.3KRT19, CDKN2A, CHGA, SYP, NKX2-1, KRT18
13lung adenocarcinoma30.3NKX2-1, CDKN2A, KRT19, KRT18, KRT7, KRT20
14hepatocellular carcinoma30.3NKX2-1, CDKN2A, KRT19, KRT18, KRT7, KRT8
15colon adenocarcinoma30.3KRT20
16thyroid medullary carcinoma30.3NKX2-1, CHGA, ENO2, ASCL1
17non-small cell lung carcinoma30.2NKX2-1, SYP, CHGA, CDKN2A, KRT19, KRT18
18basal cell carcinoma30.2KRT19, KRT7, KRT20, KRT8, TP63, TP53
19gastric adenocarcinoma30.2KRT8, KRT20, KRT7, CHGA
20cervical squamous cell carcinoma30.2TP63, KRT8, CDKN2A
21ovarian small cell carcinoma30.2TTF1
22papillary carcinoma30.1KRT20, TP63, KRT7, KRT18, NKX2-1, SYP
23adenosquamous carcinoma30.1TP63, KRT8, KRT20, KRT7, KRT19, CHGA
24tubular adenocarcinoma30.1SYP, CHGA, KRT7, KRT20, ENO2, TP63
25gastritis30.1TP53, KRT18, CHGA
26cervical adenocarcinoma30.1CDKN2A, KRT7, KRT20, KRT8
27papilloma30.1CDKN2A, KRT20, TP63, TP53
28retinoblastoma30.1SYP, CDKN2A, KRT18, ENO2, TP53
29cystadenoma30.1KRT7
30melanoma30.1NKX2-1, CDKN2A, KRT18, KRT8, ENO2, TP63
31pancreatic cancer30.1KRT19, CHGA, SYP
32endometrial carcinoma29.9NKX2-1, CDKN2A, KRT18, KRT7, KRT20, TP53
33paraganglioma29.9ENO2, CHGA, SYP
34cholangiocarcinoma29.9KRT19, KRT18, KRT7, KRT20, KRT8, TP53
35breast cancer29.9CDKN2A, KRT19, KRT18, KRT7, KRT8, TP63
36thymoma29.9TP63, NKX2-1
37hemangioma29.9NKX2-1
38barrett's esophagus29.9TP53, KRT20, KRT7, CDKN2A
39signet ring cell adenocarcinoma29.9CHGA, KRT7, KRT20
40neuroblastoma29.9TP53, ENO2, SYP
41cervical cancer29.9CDKN2A, KRT19, TP53
42ulcerative colitis29.9TP53
43sertoli cell tumor29.9ENO2, SYP
44bladder adenocarcinoma29.9KRT7, KRT20
45gastrointestinal stromal tumor29.9ENO2
46olfactory neuroblastoma29.9SYP, ENO2
47ischemia29.9NGB
48small cell carcinoma11.0
49lung large cell carcinoma10.8
50prostatitis10.6

Graphical network of the top 20 diseases related to Neuroendocrine Carcinoma:



Diseases related to neuroendocrine carcinoma

Clinical Features for Neuroendocrine Carcinoma

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Drugs & Therapeutics for Neuroendocrine Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Neuroendocrine Carcinoma

Drug clinical trials:

Search ClinicalTrials for Neuroendocrine Carcinoma

Search NIH Clinical Center for Neuroendocrine Carcinoma

Search CenterWatch for Neuroendocrine Carcinoma

Genetic Tests for Neuroendocrine Carcinoma

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Anatomical Context for Neuroendocrine Carcinoma

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Sources:
32MalaCards
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MalaCards organs/tissues related to Neuroendocrine Carcinoma:

32
Lung, Breast, Prostate, Cervix, Thyroid, Colon, Pancreas, Skin, Liver, Lymph node, Thymus, Kidney, Ovary, Adrenal gland, Tongue, Appendix, Pituitary, Endothelial, Testis, Brain, Skeletal muscle, Salivary gland, Bone, Heart, Fetal lung, Small intestine

Animal Models for Neuroendocrine Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuroendocrine Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.7TP53, NKX2-1, CHGA, CDKN2A, VGF, KRT19
2MP:001076810.6VGF, CDKN2A, NGB, CHGA, KRT19, KRT18
3MP:000301210.6NKX2-1, SYP, NGB, CDKN2A, KRT19, ASCL1
4MP:000538910.4CDKN2A, VGF, KRT19, TP53
5MP:000537810.3NKX2-1, CHGA, CDKN2A, VGF, KRT19, KRT18

Publications for Neuroendocrine Carcinoma

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Sources:
50PubMed
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Articles related to Neuroendocrine Carcinoma:

(show top 50)    (show all 894)
idTitleAuthorsYear
1
Multimodality therapy for large cell neuroendocrine carcinoma of the thymus. (24088498)
2013
2
Recurrent acute-onset Cushing's syndrome 6 years after removal of a thymic neuroendocrine carcinoma: from ectopic ACTH to CRH. (23233312)
2013
3
Prolonged clinical benefit of everolimus therapy in the management of high-grade pancreatic neuroendocrine carcinoma. (24019785)
2013
4
Primary high-grade neuroendocrine carcinoma of the heart. (23466749)
2013
5
Combined large cell neuroendocrine carcinoma with giant cell carcinoma of the lungs: a case report. (23957954)
2013
6
Metastatic primary neuroendocrine carcinoma of the genitourinary tract: A case report of an uncommon entity. (23826453)
2013
7
Mixed acinar-neuroendocrine carcinoma of the pancreas with neuroendocrine predominance. (24348574)
2013
8
Cutaneous neuroendocrine carcinoma of the external auditory canal: a case report and review of the literature. (22928140)
2012
9
Pure large cell neuroendocrine carcinoma of ovary: a rare clinical entity and review of literature. (23304586)
2012
10
Large cell neuroendocrine carcinoma of the head and neck. (22751494)
2012
11
A case of cytokeratin 20-positive large-cell neuroendocrine carcinoma of the breast. (19669861)
2012
12
Neuroendocrine carcinoma of the urinary bladder. 15-year retrospective analysis. (22414452)
2012
13
Primary neuroendocrine carcinoma of the fallopian tube: A case report. (24371668)
2012
14
Retroperitoneal neuroendocrine carcinoma with extrinsic compression of ascending colon. (22546100)
2012
15
Collision tumor in form of primary adenocarcinoma and neuroendocrine carcinoma of the duodenum. (22826777)
2012
16
The balance between the expressions of hASH1 and HES1 differs between large cell neuroendocrine carcinoma and small cell carcinoma of the lung. (21601304)
2011
17
Composite neuroendocrine carcinoma with adenocarcinoma of the stomach misdiagnosed as a giant submucosal tumor. (22076214)
2011
18
Successful treatment of gallbladder neuroendocrine carcinoma with combined chemo-radiotherapy: a case report and literature review. (21612748)
2011
19
Histologic features of low- and intermediate-grade neuroendocrine carcinoma (typical and atypical carcinoid tumors) of the lung. (20462655)
2011
20
Non-functional neuroendocrine carcinoma of the pancreas: incidence, tumor biology, and outcomes in 2,158 patients. (19997980)
2010
21
CD99-positive large cell neuroendocrine carcinoma with rearranged EWSR1 gene in an infant: a case of prognostically favorable tumor. (20617339)
2010
22
Cushing's syndrome caused by an ACTH-producing large cell neuroendocrine carcinoma of the gallbladder. (21160818)
2010
23
Glucose transporter-1 in pulmonary neuroendocrine carcinomas: expression and survival analysis. (19234439)
2009
24
A malignant cutaneous neuroendocrine tumor with features of Merkel cell carcinoma and differentiating neuroblastoma. (19318809)
2009
25
Uterine carcinosarcoma metastatic to the lung as large-cell neuroendocrine carcinoma with synchronous sarcoid granulomatosis. (19111933)
2009
26
Vasculopathic changes, a somatostatin-producing neuroendocrine carcinoma and a jejunal gastrointestinal stromal tumor in a patient with type 1 neurofibromatosis. (19488862)
2009
27
Incarceration of a large cell neuroendocrine carcinoma arising from the proximal stomach with an organoaxial gastric volvulus through an esophageal hiatal hernia: report of a case. (19198995)
2009
28
Small cell carcinomas and large cell neuroendocrine carcinomas of the endometrium and cervix: polypoid tumors and those arising in polyps may have a favorable prognosis. (18580310)
2008
29
Moderately differentiated neuroendocrine carcinoma of the larynx. (19434271)
2008
30
Fine-needle aspiration of metastatic prostatic neuroendocrine carcinomas: cytomorphologic and immunophenotypic features. (18618716)
2008
31
Miliary hepatic metastases from neuroendocrine carcinoma. (18827485)
2008
32
Primary male neuroendocrine adenocarcinoma involving the nipple simulating Merkel cell carcinoma - a diagnostic pitfall. (18190447)
2008
33
Neuroendocrine small cell carcinoma of the cervix associated with endocervical adenocarcinoma: a case report. (17718130)
2007
34
Alpha-methylacyl CoA racemase in pulmonary adenocarcinoma, squamous cell carcinoma, and neuroendocrine tumors: expression and survival analysis. (17922592)
2007
35
Neuroendocrine carcinoma of the liver associated with dermatomyositis: autopsy case and review of the literature. (17096733)
2006
36
Genetic analysis of neuroendocrine tumor cells in prostatic carcinoma. (16173029)
2006
37
Neuroendocrine carcinoma of the posterior mediastinum arising from a foregut cyst. (15871727)
2005
38
A study of moderately differentiated neuroendocrine carcinomas of the larynx and an examination of non-neoplastic larynx tissue for neuroendocrine cells. (15235358)
2004
39
Thymic neuroendocrine carcinoma (carcinoid): what if octreotide scanning is negative? (15514629)
2004
40
Ovarian non-small cell neuroendocrine carcinoma with paraneoplastic parathyroid hormone-related hypercalcemia. (15381910)
2004
41
Molecular characterization of prostatic small-cell neuroendocrine carcinoma. (12640661)
2003
42
A neuroendocrine/small cell prostate carcinoma xenograft-LuCaP 49. (12163395)
2002
43
Mucinous carcinoma of the breast with neuroendocrine differentiation. (10972863)
2000
44
CEA-producing mucin-negative gastric signet-ring cell carcinoma with neuroendocrine markers: a case report. (10405240)
1999
45
Neuroendocrine differentiation in renal cell carcinoma--evaluation of chromogranin A and neuron-specific enolase. (10427952)
1999
46
Metastatic neuroendocrine tumors to the thyroid gland mimicking medullary carcinoma: a pathologic and immunohistochemical study of six cases. (9236831)
1997
47
Relation between neuroendocrine expression of prostatic carcinoma and prognosis]. (8032980)
1994
48
Determination of plasma calcitonin gene-related peptide concentrations by a new immunochemiluminometric assay in normal persons and patients with medullary thyroid carcinoma and other neuroendocrine tumors. (1991803)
1991
49
Neural cell adhesion molecule expression, neuroendocrine differentiation and prognosis in lung carcinoma. (1851619)
1991
50
Neuroendocrine differentiation in poorly differentiated lung carcinomas: a light microscopic and immunohistologic study. (2170973)
1990

Genetic Variations for Neuroendocrine Carcinoma

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Expression for genes affiliated with Neuroendocrine Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Neuroendocrine Carcinoma.

Pathways for genes affiliated with Neuroendocrine Carcinoma

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Sources:
4Cell Signaling Technology, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5KRT8, KRT7, KRT18, KRT19
210.5KRT8, KRT7, KRT18, KRT19
310.5TP53, TP63, CDKN2A
410.5KRT19, KRT8, TP53
5
Hide members
10.5TP53, TP63

Compounds for genes affiliated with Neuroendocrine Carcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1paraffin4411.1TP53, TP63, ENO2, KRT8, KRT20, KRT7
2progesterone44 59 28 11 2415.1NKX2-1, SYP, CHGA, CDKN2A, KRT19, KRT18
3retinoic acid44 2412.1KRT19, CDKN2A, CHGA, SYP, NKX2-1, KRT18
4vegf4411.1KRT19, VGF, CDKN2A, CHGA, SYP, KRT18
5hematoxylin4411.1KRT18, KRT19, CDKN2A, CHGA, SYP, NKX2-1
6tyrosine4411.1NKX2-1, SYP, CHGA, VGF, KRT19, KRT18
7testosterone44 59 11 2414.1SYP, CHGA, CDKN2A, KRT19, KRT18, KRT7
8b 7234411.0TP63, KRT8, KRT20, KRT7, KRT19, CHGA
9formaldehyde44 2412.0NKX2-1, SYP, CHGA, KRT19, KRT18, KRT7
10cisplatin44 49 59 1114.0SYP, CHGA, CDKN2A, KRT19, KRT8, ENO2
11iron44 2412.0LCN1, NGB, CDKN2A, KRT19, KRT18, KRT7
12forskolin44 49 1113.0NKX2-1, SYP, CHGA, VGF, KRT18, KRT8
13glycogen44 2412.0SYP, CHGA, KRT19, KRT18, KRT7, KRT8
14mucicarmine4411.0NKX2-1, SYP, KRT7, KRT20, TP63
15lipid4411.0LCN1, SYP, CHGA, NGB, CDKN2A, KRT18
16bromodeoxyuridine4411.0CHGA, KRT19, KRT18, KRT8, ENO2, TP63
17creatinine4411.0LCN1, SYP, CHGA, CDKN2A, KRT19, KRT18
18sucrose44 11 2413.0SYP, CHGA, KRT19, KRT18, KRT20, KRT8
19steroid4411.0NKX2-1, SYP, CDKN2A, KRT19, KRT18, KRT8
20smcc4411.0SYP, CHGA, KRT19, ENO2
21matrigel4411.0CHGA, KRT19, KRT18, KRT7, KRT8, TP63
22gold4411.0SYP, CHGA, CDKN2A, KRT18, KRT8
23glucose4410.9NGB, CDKN2A, KRT19, KRT18, KRT7, KRT8
24doxorubicin44 49 1112.9CDKN2A, KRT18, KRT20, KRT8, TP63, TP53
25lactate4410.9LCN1, CHGA, KRT19, KRT18, KRT8, ENO2
26s 1004410.9SYP, CHGA, ENO2
27silver4410.9ENO2, CDKN2A, CHGA, SYP
28thymidine44 2411.9TP53, TP63, ENO2, KRT18, KRT19, VGF
29retinoid4410.9KRT19, KRT18, KRT7, KRT8, TP53
30dopamine44 28 11 2413.9CHGA, KRT18, ENO2
31ribonucleic acid4410.9ENO2, KRT20, KRT19, CHGA, NKX2-1
32histidine4410.9SYP, CHGA, NGB, CDKN2A, TP63
33paclitaxel44 49 1112.9TP53, KRT8, KRT19, CDKN2A, CHGA
34etoposide44 49 59 1113.8CHGA, KRT8
35oxygen44 2411.8LCN1, CHGA, NGB, CDKN2A, KRT19, KRT18
36l-amino acid4410.8SYP, CHGA, ENO2
37docetaxel44 49 59 1113.8CDKN2A, KRT18, ENO2, TP53
38adriamycin4410.8KRT8, CDKN2A
39oligonucleotide4410.8NKX2-1, CHGA, CDKN2A, KRT18, KRT8, TP53
40fitc4410.8KRT19, KRT18, KRT8
41hyaluronic acid44 2411.8LCN1, KRT19, KRT20, ENO2
42dutp4410.8TP53, KRT18, SYP
43serine4410.7NKX2-1, SYP, CHGA, CDKN2A, KRT19, KRT18
44methanol44 2411.7KRT7, CDKN2A, CHGA
45dexamethasone44 49 28 1113.7NKX2-1, CDKN2A, KRT18, ENO2
46estracyt4410.6CHGA, ENO2
47dmso4410.5TP63, ENO2, KRT18, CHGA
48metanephrine44 2411.5ENO2, CHGA
49chloride4410.4LCN1, KRT19, KRT8, ENO2
50nitric oxide44 11 2412.3SYP, CHGA, NGB, CDKN2A, KRT18, ENO2

GO Terms for genes affiliated with Neuroendocrine Carcinoma

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16Gene Ontology
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Cellular components related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:00573010.6TTF1, PNMA2, KRT18, KRT7, TP63, TP53
2intermediate filamentGO:00588210.5KRT8, KRT20, KRT7, KRT18, KRT19
3nucleoplasmGO:00565410.5NKX2-1, CDKN2A, TTF1, KRT8, TP63, TP53
4keratin filamentGO:04509510.2KRT8, KRT7, KRT18

Biological processes related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1modulation by virus of host morphology or physiologyGO:01904810.7KRT19, KRT18, KRT7, KRT8, TP53
2cerebral cortex GABAergic interneuron differentiationGO:02189210.7ASCL1, NKX2-1
3apoptotic processGO:00691510.6NGB, PNMA2, KRT18, KRT20, KRT8, TP63
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.5TP53, TP63
5cell differentiation involved in embryonic placenta developmentGO:06070610.5KRT8, KRT19
6mitotic G1 DNA damage checkpointGO:03157110.4TP63, TP53
7replicative senescenceGO:09039910.2TP53, CDKN2A

Molecular functions related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00203910.5TP53, TP63, CDKN2A
2MDM2/MDM4 family protein bindingGO:09737110.2TP53, CDKN2A

Products for genes affiliated with Neuroendocrine Carcinoma

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  • Antibodies
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Sources for Neuroendocrine Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet