MCID: NRN001
MIFTS: 57

Neuroendocrine Carcinoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Neuroendocrine Carcinoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A carcinoma that derives from neuroendocrine cells.

MalaCards: Neuroendocrine Carcinoma, also known as carcinoma, neuroendocrine, is related to large cell carcinoma and neuroendocrine tumor. An important gene associated with Neuroendocrine Carcinoma is GPR112 (G protein-coupled receptor 112), and among its related pathways are Cytoskeletal Signaling and Cytoskeleton remodeling Keratin filaments. The compounds paraffin and progesterone have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and prostate, and related mouse phenotypes are endocrine/exocrine gland and mortality/aging.

Aliases & Classifications for Neuroendocrine Carcinoma

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroendocrine carcinoma 8
carcinoma, neuroendocrine 60


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Disease Ontology8 DOID:1800
MeSH34 D018278
SNOMED-CT56 253000007, 55937004
NCIt39 C3773

Related Diseases for Neuroendocrine Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 284)
idRelated DiseaseScoreTop Affiliating Genes
1large cell carcinoma31.6TP63, ENO2, KRT20, KRT7, CHGA, SYP
2neuroendocrine tumor31.1SYP, CHGA, KRT19, KRT20, KRT8, ENO2
3adenocarcinoma31.1KRT19, CDKN2A, CHGA, SYP, NKX2-1, KRT18
4pulmonary large cell neuroendocrine carcinoma31.0LCN1
5merkel cell carcinoma30.9NKX2-1, SYP, CHGA, KRT20, KRT8, ENO2
6bladder carcinoma30.9CDKN2A, KRT19, KRT18, KRT20, KRT8, TP63
7lung small cell carcinoma30.9NKX2-1, TP53, TP63, ASCL1, ENO2, KRT8
8hepatitis30.7KRT8
9squamous cell carcinoma30.6CHGA, CDKN2A, KRT19, KRT18, KRT7, KRT20
10lung cancer30.5NKX2-1, CHGA, CDKN2A, KRT19, KRT18, KRT8
11prostate cancer30.4CHGA, KRT18, KRT7, KRT8, ENO2, TP63
12adenoma30.3KRT19, CDKN2A, CHGA, SYP, NKX2-1, KRT18
13lung adenocarcinoma30.3NKX2-1, CDKN2A, KRT19, KRT18, KRT7, KRT20
14hepatocellular carcinoma30.3NKX2-1, CDKN2A, KRT19, KRT18, KRT7, KRT8
15colon adenocarcinoma30.3KRT20
16thyroid medullary carcinoma30.3NKX2-1, CHGA, ENO2, ASCL1
17non-small cell lung carcinoma30.2NKX2-1, SYP, CHGA, CDKN2A, KRT19, KRT18
18basal cell carcinoma30.2KRT19, KRT7, KRT20, KRT8, TP63, TP53
19gastric adenocarcinoma30.2KRT8, KRT20, KRT7, CHGA
20cervical squamous cell carcinoma30.2TP63, KRT8, CDKN2A
21ovarian small cell carcinoma30.2TTF1
22papillary carcinoma30.1KRT20, TP63, KRT7, KRT18, NKX2-1, SYP
23adenosquamous carcinoma30.1TP63, KRT8, KRT20, KRT7, KRT19, CHGA
24tubular adenocarcinoma30.1SYP, CHGA, KRT7, KRT20, ENO2, TP63
25gastritis30.1TP53, KRT18, CHGA
26cervical adenocarcinoma30.1CDKN2A, KRT7, KRT20, KRT8
27papilloma30.1CDKN2A, KRT20, TP63, TP53
28retinoblastoma30.1SYP, CDKN2A, KRT18, ENO2, TP53
29cystadenoma30.1KRT7
30melanoma30.1NKX2-1, CDKN2A, KRT18, KRT8, ENO2, TP63
31pancreatic cancer30.1KRT19, CHGA, SYP
32endometrial carcinoma29.9NKX2-1, CDKN2A, KRT18, KRT7, KRT20, TP53
33paraganglioma29.9ENO2, CHGA, SYP
34cholangiocarcinoma29.9KRT19, KRT18, KRT7, KRT20, KRT8, TP53
35breast cancer29.9CDKN2A, KRT19, KRT18, KRT7, KRT8, TP63
36thymoma29.9TP63, NKX2-1
37hemangioma29.9NKX2-1
38barrett's esophagus29.9TP53, KRT20, KRT7, CDKN2A
39signet ring cell adenocarcinoma29.9CHGA, KRT7, KRT20
40neuroblastoma29.9TP53, ENO2, SYP
41cervical cancer29.9CDKN2A, KRT19, TP53
42ulcerative colitis29.9TP53
43sertoli cell tumor29.9ENO2, SYP
44bladder adenocarcinoma29.9KRT7, KRT20
45gastrointestinal stromal tumor29.9ENO2
46olfactory neuroblastoma29.9SYP, ENO2
47ischemia29.9NGB
48small cell carcinoma11.0
49lung large cell carcinoma10.8
50prostatitis10.6

Graphical network of the top 20 diseases related to Neuroendocrine Carcinoma:



Diseases related to neuroendocrine carcinoma

Clinical Features for Neuroendocrine Carcinoma

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Drugs & Therapeutics for Neuroendocrine Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Neuroendocrine Carcinoma

Drug clinical trials:

Search ClinicalTrials for Neuroendocrine Carcinoma

Search NIH Clinical Center for Neuroendocrine Carcinoma

Search CenterWatch for Neuroendocrine Carcinoma

Genetic Tests for Neuroendocrine Carcinoma

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Anatomical Context for Neuroendocrine Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Neuroendocrine Carcinoma:

32
Lung, Breast, Prostate, Cervix, Thyroid, Colon, Skin, Pancreas, Liver, Lymph node, Thymus, Kidney, Ovary, Adrenal gland, Testis, Tongue, Pituitary, Skeletal muscle, Appendix, Brain, Endothelial, Fetal lung, Salivary gland, Small intestine, Heart, Bone

Animal Models for Neuroendocrine Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuroendocrine Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.7TP53, NKX2-1, CHGA, CDKN2A, VGF, KRT19
2MP:001076810.6VGF, CDKN2A, NGB, CHGA, KRT19, KRT18
3MP:000301210.6NKX2-1, SYP, NGB, CDKN2A, KRT19, ASCL1
4MP:000538910.4CDKN2A, VGF, KRT19, TP53
5MP:000537810.3NKX2-1, CHGA, CDKN2A, VGF, KRT19, KRT18

Publications for Neuroendocrine Carcinoma

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Sources:
50PubMed
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Articles related to Neuroendocrine Carcinoma:

(show top 50)    (show all 894)
idTitleAuthorsYear
1
Mammary neuroendocrine carcinoma with mucinous differentiation: a clinicopathological study of 15 cases. (24004514)
2013
2
Large cell neuroendocrine carcinoma (LCNEC) of the urinary bladder: a case report. (23379295)
2013
3
68Ga DOTANOC PET/CT for accurate delineation of disease extent in a case of sinonasal small cell neuroendocrine carcinoma. (23603589)
2013
4
Combined large cell neuroendocrine carcinoma and adenocarcinoma of the gallbladder. (23242533)
2013
5
Transformation of nonfunctioning pancreatic neuroendocrine carcinoma cells into insulin producing cells after treatment with sunitinib. (24396670)
2013
6
Conditional deletion of p53 and Rb in the renin-expressing compartment of the pancreas leads to a highly penetrant metastatic pancreatic neuroendocrine carcinoma. (24292676)
2013
7
Small cell neuroendocrine carcinoma of the paranasal sinus. (24163566)
2013
8
Neuroendocrine carcinoma of the head and neck: a 20-year case series. (22430343)
2012
9
Vulvar encapsulated solid papillary carcinoma with neuroendocrine differentiation: a case report. (21427093)
2012
10
A novel case of concurrent renal tumors: chromophobe renal cell carcinoma and carcinoid tumor of the kidney with brief review of renal neuroendocrine tumors. (22456871)
2012
11
Effect of chemotherapy in patients with resected small-cell or large-cell neuroendocrine carcinoma. (22617247)
2012
12
Large-cell neuroendocrine carcinoma with epidermal growth factor receptor mutation: possible transformation of lung adenocarcinoma. (22943430)
2012
13
Solitary atrial myocardial metastasis revealing ileal neuroendocrine carcinoma. (22138424)
2012
14
Double neuroendocrine ductal carcinomas in situ coexisting with a background of diffuse idiopathic neuroendocrine cell hyperplasia of breast: a case report and hypothesis of neuroendocrine tumor development. (22524661)
2012
15
Chromophobe renal cell carcinoma with neuroendocrine differentiation and sarcomatoid change. (21884307)
2011
16
Ileal neuroendocrine carcinoma following restorative proctocolectomy for colonic adenocarcinoma in Crohn's disease. (20532536)
2011
17
Hepatic Metastasis of Composite Adenocarcinoma and Neuroendocrine Carcinoma. (21519810)
2011
18
Bilateral primary breast neuroendocrine carcinoma in a young woman: report of a case. (21969166)
2011
19
Distinction of high-grade neuroendocrine carcinoma/small cell carcinoma from conventional urothelial carcinoma of urinary bladder: an immunohistochemical approach. (21617524)
2011
20
Neuroendocrine carcinoma of the esophagus: a case report with immunohistochemical and molecular genetic analyses of KIT and PDGFRA. (20354820)
2011
21
Amrubicin monotherapy for patients with previously treated advanced large-cell neuroendocrine carcinoma of the lung. (21636606)
2011
22
Primary neuroendocrine carcinoma of breast. (21713100)
2011
23
Thymic neuroendocrine carcinoma presenting as cushing's syndrome: treatment with octreotide combined with surgery and radiotherapy. (21346385)
2011
24
Multicentric cutaneous neuroendocrine (Merkel cell) carcinoma in a dog. (20634406)
2010
25
Urinary cytologic features of primary large cell neuroendocrine carcinoma of the urinary bladder: a case report. (20518415)
2010
26
Primary neuroendocrine carcinoma of thymus: a rare cause of Cushing's syndrome. (20090249)
2010
27
An immunohistochemical study of cervical neuroendocrine carcinomas: Neoplasms that are commonly TTF1 positive and which may express CK20 and P63. (20182342)
2010
28
Immunohistochemical expression of somatostatin type 2A receptor in neuroendocrine carcinoma of uterine cervix. (18726606)
2009
29
Large cell neuroendocrine carcinoma of the gallbladder: long survival achieved by multimodal treatment. (19705247)
2009
30
Large cell neuroendocrine carcinoma of the tongue base: case report of an unusual location with immunohistochemical analysis. (19167190)
2009
31
Collision tumour of the stomach--adenocarcinoma and neuroendocrine carcinoma: case report and review of the literature. (19886184)
2009
32
Neuroendocrine carcinoma of unknown primary site. (19179188)
2009
33
Fine-needle aspiration cytology of large cell neuroendocrine carcinoma of the lung: a cytohistologic correlation study of 11 cases. (18433011)
2008
34
Nasopharyngeal neuroendocrine carcinoma: a case report. (19105129)
2008
35
Paraneoplastic neuromuscular disease in lung large cell neuroendocrine carcinoma. (18973075)
2008
36
A case series and immunophenotypic analysis of CK20-/CK7+ primary neuroendocrine carcinoma of the skin. (18001414)
2007
37
Primary cutaneous neuroendocrine cell carcinoma (Merkel cell carcinoma) with prominent microcystic features, mimicking eccrine carcinoma. (17448197)
2007
38
Neuroendocrine gastric carcinoma expressing somatostatin: a highly malignant, rare tumor. (16804989)
2006
39
Aberrant expression of human achaete-scute homologue gene 1 in the gastrointestinal neuroendocrine carcinomas. (15701827)
2005
40
Metastatic renal cell carcinoma versus pancreatic neuroendocrine tumor in von Hippel-Lindau disease: treatment with interleukin-2. (15674444)
2005
41
Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells. (15466176)
2004
42
Primary small cell neuroendocrine carcinoma of the breast. (15743041)
2004
43
Neuroendocrine differentiated carcinomas of the breast: a distinct entity. (14659309)
2003
44
Immunohistochemical neuroendocrine differentiation is an independent prognostic factor in surgically resected large cell carcinoma of the lung. (12399130)
2002
45
Intraarterial neoadjuvant chemotherapy with cisplatin effective against neuroendocrine carcinoma of the urinary bladder: a case report]. (12229180)
2002
46
Differential diagnosis of calcitonin-secreting neuroendocrine carcinoma of the foregut by pentagastrin stimulation. (11127524)
2000
47
Detection of neuroendocrine feature about salivary adenoid cystic carcinoma. (10863420)
1999
48
Composite early carcinoma (ordinary adenocarcinoma, carcinoid, microglandular-goblet cell carcinoid, neuroendocrine mucinous carcinoma) of the stomach. (9675600)
1998
49
A comparative study of neuroendocrine carcinoma and carcinoid tumor with special reference to expression of HLA-DR antigen and PCNA. (7690246)
1993
50
Gastric small cell carcinoma with squamous and neuroendocrine differentiation. (1322519)
1992

Genetic Variations for Neuroendocrine Carcinoma

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Expression for genes affiliated with Neuroendocrine Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Neuroendocrine Carcinoma.

Pathways for genes affiliated with Neuroendocrine Carcinoma

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Sources:
4Cell Signaling Technology, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5KRT8, KRT7, KRT18, KRT19
210.5KRT8, KRT7, KRT18, KRT19
310.5TP53, TP63, CDKN2A
410.5KRT19, KRT8, TP53
5
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10.5TP53, TP63

Compounds for genes affiliated with Neuroendocrine Carcinoma

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1paraffin4411.1NKX2-1, SYP, CDKN2A, KRT18, KRT7, KRT20
2progesterone44 59 28 11 2415.1NKX2-1, TP63, TP53, KRT8, KRT20, CDKN2A
3retinoic acid44 2412.1CDKN2A, KRT19, KRT18, KRT7, KRT8, TP63
4hematoxylin4411.1NKX2-1, KRT20, KRT7, KRT18, KRT19, CDKN2A
5vegf4411.1CHGA, CDKN2A, VGF, KRT19, KRT18, KRT7
6tyrosine4411.1KRT7, NKX2-1, CHGA, VGF, KRT19, KRT18
7testosterone44 59 11 2414.1KRT18, KRT7, KRT20, KRT8, TP63, KRT19
8b 7234411.0NKX2-1, SYP, CHGA, KRT19, KRT20, KRT8
9formaldehyde44 2412.0KRT7, CHGA, KRT19, NKX2-1, ENO2, KRT18
10cisplatin44 49 59 1114.0CDKN2A, CHGA, TP63, ENO2, KRT8, KRT19
11iron44 2412.0KRT20, KRT8, KRT19, KRT18, KRT7, CDKN2A
12forskolin44 49 1113.0SYP, KRT18, KRT8, ENO2, NKX2-1, CHGA
13glycogen44 2412.0ENO2, CHGA, KRT19, KRT7, KRT8, KRT18
14mucicarmine4411.0KRT20, KRT7, TP63, SYP, NKX2-1
15lipid4411.0SYP, ENO2, KRT8, KRT7, LCN1, KRT18
16bromodeoxyuridine4411.0KRT18, CHGA, TP63, ENO2, KRT19, KRT8
17creatinine4411.0CHGA, KRT19, CDKN2A, LCN1, KRT18, SYP
18sucrose44 11 2413.0KRT8, KRT20, KRT18, KRT19, CHGA, SYP
19steroid4411.0SYP, CDKN2A, KRT19, KRT18, KRT8, NKX2-1
20smcc4411.0ENO2, KRT19, CHGA, SYP
21matrigel4411.0CHGA, KRT19, KRT7, KRT8, TP63, KRT18
22gold4411.0KRT8, KRT18, CDKN2A, CHGA, SYP
23glucose4410.9KRT19, KRT8, KRT18, KRT7, CDKN2A, NGB
24doxorubicin44 49 1112.9KRT18, TP53, TP63, KRT8, KRT20, CDKN2A
25lactate4410.9CHGA, ENO2, LCN1, KRT8, KRT18, KRT19
26s 1004410.9CHGA, SYP, ENO2
27silver4410.9ENO2, CDKN2A, CHGA, SYP
28thymidine44 2411.9KRT18, VGF, TP53, TP63, ENO2, KRT19
29retinoid4410.9KRT7, KRT19, KRT18, KRT8, TP53
30dopamine44 28 11 2413.9KRT18, CHGA, ENO2
31ribonucleic acid4410.9KRT20, KRT19, CHGA, ENO2, NKX2-1
32histidine4410.9CDKN2A, TP63, CHGA, NGB, SYP
33paclitaxel44 49 1112.9CHGA, KRT8, KRT19, CDKN2A, TP53
34etoposide44 49 59 1113.8CHGA, KRT8
35oxygen44 2411.8LCN1, CHGA, NGB, CDKN2A, ENO2, KRT18
36l-amino acid4410.8ENO2, CHGA, SYP
37docetaxel44 49 59 1113.8TP53, KRT18, ENO2, CDKN2A
38adriamycin4410.8CDKN2A, KRT8
39oligonucleotide4410.8TP53, CDKN2A, CHGA, NKX2-1, KRT8, KRT18
40fitc4410.8KRT18, KRT8, KRT19
41hyaluronic acid44 2411.8ENO2, KRT20, KRT19, LCN1
42dutp4410.8SYP, KRT18, TP53
43serine4410.7KRT19, CDKN2A, KRT18, CHGA, KRT8, TP53
44methanol44 2411.7KRT7, CHGA, CDKN2A
45dexamethasone44 49 28 1113.7ENO2, KRT18, NKX2-1, CDKN2A
46estracyt4410.6CHGA, ENO2
47dmso4410.5TP63, ENO2, CHGA, KRT18
48metanephrine44 2411.5CHGA, ENO2
49chloride4410.4ENO2, KRT19, LCN1, KRT8
50nitric oxide44 11 2412.3SYP, KRT18, ENO2, CDKN2A, CHGA, NGB

GO Terms for genes affiliated with Neuroendocrine Carcinoma

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16Gene Ontology
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Cellular components related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleolusGO:00573010.6TTF1, PNMA2, KRT18, KRT7, TP63, TP53
2intermediate filamentGO:00588210.5KRT8, KRT20, KRT7, KRT18, KRT19
3nucleoplasmGO:00565410.5NKX2-1, CDKN2A, TTF1, KRT8, TP63, TP53
4keratin filamentGO:04509510.2KRT8, KRT7, KRT18

Biological processes related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1modulation by virus of host morphology or physiologyGO:01904810.7KRT19, KRT18, KRT7, KRT8, TP53
2cerebral cortex GABAergic interneuron differentiationGO:02189210.7ASCL1, NKX2-1
3apoptotic processGO:00691510.6NGB, PNMA2, KRT18, KRT20, KRT8, TP63
4DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.5TP53, TP63
5cell differentiation involved in embryonic placenta developmentGO:06070610.5KRT8, KRT19
6mitotic G1 DNA damage checkpointGO:03157110.4TP63, TP53
7replicative senescenceGO:09039910.2TP53, CDKN2A

Molecular functions related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00203910.5TP53, TP63, CDKN2A
2MDM2/MDM4 family protein bindingGO:09737110.2TP53, CDKN2A

Products for genes affiliated with Neuroendocrine Carcinoma

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  • Antibodies
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Sources for Neuroendocrine Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet