MCID: NRN001
MIFTS: 59

Neuroendocrine Carcinoma malady

Cancer diseases, Neuronal diseases categories
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Summaries for Neuroendocrine Carcinoma

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Disease Ontology:8 A carcinoma that derives from neuroendocrine cells.

MalaCards based summary: Neuroendocrine Carcinoma, also known as carcinoma, neuroendocrine, is related to merkel cell carcinoma and neuroendocrine tumor. An important gene associated with Neuroendocrine Carcinoma is GPR112 (G protein-coupled receptor 112), and among its related pathways are Cytoskeleton remodeling Keratin filaments and TP53 network. The compounds mucicarmine and silver have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and cervix, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Aliases & Classifications for Neuroendocrine Carcinoma

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Neuroendocrine Carcinoma, Aliases & Descriptions:

Name: Neuroendocrine Carcinoma 8
 
Carcinoma, Neuroendocrine 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:1800
MeSH34 D018278
SNOMED-CT57 253000007, 55937004
NCIt39 C3773

Related Diseases for Neuroendocrine Carcinoma

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Diseases related to Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1merkel cell carcinoma31.4NKX2-1, SYP, CHGA
2neuroendocrine tumor31.3CHGA
3large cell carcinoma30.4TP63, CHGA, NKX2-1, SYP
4paraganglioma30.4CHGA, SYP
5lung cancer30.4CHGA, NKX2-1, SYP, TP63, KRT18
6cervical squamous cell carcinoma30.3CDKN2A, TP63, KRT8
7pleomorphic adenoma30.3TP63, KRT18
8thyroid medullary carcinoma30.3NOTCH1, NKX2-1, CHGA
9adenosquamous carcinoma30.2TP63, CHGA, NKX2-1, KRT8
10basal cell carcinoma30.2KRT8, TP63, CTNNB1
11retinoblastoma30.1KRT18, SYP, CDKN2A
12cholangiocarcinoma30.1KRT18, CDH1, KRT8
13breast cancer30.0NOTCH1, CTNNB1, CDH1
14pancreatic cancer29.9KRT8, CDH1, CDKN2A
15tubular adenocarcinoma29.7TP63, CHGA, SYP, CDH1, CTNNB1
16lung small cell carcinoma29.6CHGA, TP63, KRT8, NKX2-1, SYP, KRT18
17adenocarcinoma29.2NKX2-1, KRT18, TP63, CHGA, CTNNB1, CDKN2A
18prostate cancer29.2CDH1, KRT18, TP63, CHGA, KRT8, NOTCH1
19ovarian cancer28.9CDKN2A, KRT8, KRT18, NOTCH1, CDH1, CTNNB1
20lung adenocarcinoma28.9CDKN2A, KRT18, KRT8, TP63, CDH1, CTNNB1
21adenoma28.7TP63, KRT8, NKX2-1, SYP, CHGA, CTNNB1
22melanoma28.6CTNNB1, TP63, NKX2-1, KRT18, NOTCH1, CDKN2A
23large cell neuroendocrine carcinoma11.2
24small cell neuroendocrine carcinoma11.0
25pulmonary large cell neuroendocrine carcinoma10.7
26prostatitis10.7
27pancreatitis10.6
28thymic neuroendocrine carcinoma10.6
29small cell carcinoma10.6
30hepatitis10.6
31neuroendocrine carcinoma of the cervix10.6
32pulmonary blastoma10.5NKX2-1
33dysembryoplastic neuroepithelial tumor10.5SYP
34cushing's syndrome10.5
35thyroiditis10.5
36ovarian large-cell neuroendocrine carcinoma10.4
37cervicitis10.4
38leukoplakia10.4KRT8
39actinic keratosis10.4TP63
40central neurocytoma10.4CHGA, SYP
41sinusitis10.4
42laryngitis10.4
43teratoma10.4
44pancreatic islet cell tumors10.4CHGA, SYP
45endocrine gland cancer10.4CHGA, SYP
46pineocytoma10.4CHGA, SYP
47ganglioglioma10.3SYP, CHGA
48gastrinoma10.3CHGA, SYP
49pancreatic ductal carcinoma10.3KRT8, CHGA
50cirrhosis, noncryptogenic10.3KRT18, KRT8

Graphical network of the top 20 diseases related to Neuroendocrine Carcinoma:



Diseases related to neuroendocrine carcinoma

Symptoms for Neuroendocrine Carcinoma

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Drugs & Therapeutics for Neuroendocrine Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Neuroendocrine Carcinoma

Search NIH Clinical Center for Neuroendocrine Carcinoma

Genetic Tests for Neuroendocrine Carcinoma

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Anatomical Context for Neuroendocrine Carcinoma

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MalaCards organs/tissues related to Neuroendocrine Carcinoma:

32
Lung, Breast, Cervix, Prostate, Colon, Pancreas, Skin, Liver, Lymph node, Thymus, Thyroid, Ovary, Kidney, Brain, Adrenal gland, Testis, Endothelial, Bone, Heart, Skeletal muscle, Small intestine, Salivary gland, Tonsil, Tongue, Appendix, Bronchial epithelium

Animal Models for Neuroendocrine Carcinoma or affiliated genes

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Publications for Neuroendocrine Carcinoma

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Articles related to Neuroendocrine Carcinoma:

(show top 50)    (show all 723)
idTitleAuthorsYear
1
Primary neuroendocrine carcinoma of male breast: A cytologically diagnosed rare entity. (25210242)
2014
2
Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp. (24966991)
2014
3
Treatment options for patients with large cell neuroendocrine carcinoma of the lung. (24719260)
2014
4
Impact of histological subtype on long-term outcomes of neuroendocrine carcinoma of the breast. (25399232)
2014
5
Solid neuroendocrine carcinoma of the breast: a rare tumor. (24984553)
2014
6
Metastatic small cell neuroendocrine carcinoma of the pelvic floor. (24065309)
2013
7
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of large cell neuroendocrine carcinoma of the gallbladder and common bile duct: report of a case. (22623519)
2013
8
Multimodality therapy for large cell neuroendocrine carcinoma of the thymus. (24088498)
2013
9
A rare breast tumor: solid neuroendocrine carcinoma. (22672972)
2013
10
Primary neuroendocrine carcinoma of ocular adnexa. (24294530)
2013
11
Mixed large cell neuroendocrine carcinoma with squamous cell carcinoma of the rectum: Report of a rare case and review of the literature. (24240071)
2013
12
Mammary neuroendocrine carcinoma with mucinous differentiation: a clinicopathological study of 15 cases. (24004514)
2013
13
Primary cutaneous neuroendocrine carcinoma, Merkel cell carcinoma. Case series 1991-2012. (24094946)
2013
14
Neuroendocrine carcinoma of the extrahepatic bile duct: case report and literature review. (23901240)
2013
15
Treatment of poorly differentiated neuroendocrine carcinoma of the pancreas. (23846932)
2013
16
Paranasal sinus neuroendocrine carcinoma: a case report and review of the literature. (23476846)
2013
17
Large cell neuroendocrine carcinoma of female genital tract: a clinicopathological study of two cases with review of literature. (24426770)
2013
18
Ectopic adrenalcorticotropic hormone syndrome improved by transarterial embolization to hepatic metastatic lesions of pancreatic neuroendocrine carcinoma: a case report. (23071243)
2012
19
Late recurrence of a seminoma of the testis with a poorly differentiated neuroendocrine carcinoma component. (22084429)
2012
20
Ten years survival with excellent outcome after living donor liver transplantation from 70 years old donor for primary hepatic neuroendocrine carcinoma: Case report. (22288038)
2012
21
Metastatic 5-mm rectal neuroendocrine carcinoma. (21664197)
2011
22
Refractory gastroesophageal variceal bleeding secondary to neuroendocrine carcinoma in the pancreatic tail. (21577041)
2011
23
A phase II trial of imatinib mesylate in merkel cell carcinoma (neuroendocrine carcinoma of the skin): A Southwest Oncology Group study (S0331). (20019577)
2010
24
Primary neuroendocrine carcinoma coexisting with hemangioma in the liver: report of a case. (20107963)
2010
25
Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum. (20162505)
2010
26
Neuroendocrine Carcinoma of the Bladder. (20740160)
2010
27
Diffuse pancreatic serous cystadenoma associated with neuroendocrine carcinoma: a case report and review of literature. (19129617)
2009
28
Glucose transporter-1 in pulmonary neuroendocrine carcinomas: expression and survival analysis. (19234439)
2009
29
Large-cell neuroendocrine carcinoma of the kidney: Clinicopathologic features. (19672368)
2009
30
Expression of Notch-1 and alteration of the E-cadherin/beta-catenin cell adhesion complex are observed in primary cutaneous neuroendocrine carcinoma (Merkel cell carcinoma). (19396152)
2009
31
Primary neuroendocrine carcinoma of the breast. (19136787)
2009
32
Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate. (19125417)
2009
33
Combined primary neuroendocrine carcinoma and hepatocellular carcinoma of the liver. (19686999)
2009
34
Postirradiated neuroendocrine carcinoma of the sinonasal tract. (18520182)
2008
35
Small cell carcinomas and large cell neuroendocrine carcinomas of the endometrium and cervix: polypoid tumors and those arising in polyps may have a favorable prognosis. (18580310)
2008
36
Neuroendocrine carcinoma of the breast. Our experience and a proposal of a therapeutic algorithm for a rare tumor]. (18507954)
2008
37
Neuroendocrine carcinoma metastatic to the breast. (18248556)
2008
38
Fine-needle aspiration cytology of large cell neuroendocrine carcinoma of the lung: a cytohistologic correlation study of 11 cases. (18433011)
2008
39
A case series and immunophenotypic analysis of CK20-/CK7+ primary neuroendocrine carcinoma of the skin. (18001414)
2007
40
Role of chemotherapy and the receptor tyrosine kinases KIT, PDGFRalpha, PDGFRbeta, and Met in large-cell neuroendocrine carcinoma of the lung. (16314638)
2005
41
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. (15022286)
2004
42
The prognostic role of c-kit protein expression in resected large cell neuroendocrine carcinoma of the lung. (14726070)
2004
43
A study of moderately differentiated neuroendocrine carcinomas of the larynx and an examination of non-neoplastic larynx tissue for neuroendocrine cells. (15235358)
2004
44
Primary coexistent neuroendocrine carcinoma, hepatoid adenocarcinoma, and tubular adenocarcinoma of the stomach with focal trophoblastic differentiation in metastatic lymph nodes. (12858843)
2003
45
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (11510007)
2001
46
Small cell neuroendocrine carcinoma of the thymus complicated by Cushing's syndrome. Report of a 58-year-old woman with a 3-year history of hypertension. (11261817)
2001
47
Anti-Ri-associated paraneoplastic cerebellar degeneration without opsoclonus in a patient with a neuroendocrine carcinoma of the stomach. (10826224)
2000
48
Primary hepatic carcinoid and neuroendocrine carcinoma: clinicopathological and immunohistochemical study of five cases. (10365851)
1999
49
Large cell neuroendocrine carcinoma of the lung: a histologic and immunohistochemical study of 22 cases. (9591721)
1998
50
Immunohistochemical and flow cytometric study of neuroendocrine carcinoma of the skin. (7551012)
1995

Variations for Neuroendocrine Carcinoma

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Expression for genes affiliated with Neuroendocrine Carcinoma

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Expression patterns in normal tissues for genes affiliated with Neuroendocrine Carcinoma

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Pathways for genes affiliated with Neuroendocrine Carcinoma

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Pathways related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7KRT18, KRT8
2
Show member pathways
9.4CDKN2A, TP63
39.4NOTCH1, NKX2-1, SYP
49.2NOTCH1, CTNNB1
59.2CTNNB1, NOTCH1
69.1CDH1, KRT18, KRT8
79.0CTNNB1, CDH1
89.0CDH1, CTNNB1
99.0CTNNB1, CDH1
109.0CDH1, CTNNB1
119.0CTNNB1, CDH1
129.0CDH1, CTNNB1
139.0TP63, NOTCH1, CDKN2A
14
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion60
Pathogenic Escherichia coli infection37
8.7CTNNB1, CDH1, KRT18
158.6NOTCH1, CDH1, CTNNB1
168.6CTNNB1, CDH1, NOTCH1
178.5CTNNB1, CDH1, CDKN2A
18
Show member pathways
Signaling Pathways in Glioblastoma37
8.5CTNNB1, CDH1, CDKN2A
19
Show member pathways
7.7KRT18, NOTCH1, CDKN2A, CDH1, CTNNB1

Compounds for genes affiliated with Neuroendocrine Carcinoma

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Compounds related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1mucicarmine449.7TP63, SYP, NKX2-1
2silver449.1CHGA, SYP, CDKN2A, CDH1
3forskolin44 50 1111.0KRT18, KRT8, NKX2-1, SYP, CHGA
4gold449.0CHGA, SYP, KRT8, KRT18, CDKN2A
5formaldehyde44 249.9CHGA, SYP, NKX2-1, KRT18, CDH1
6sodium bisulfite448.8CDKN2A, CDH1, CTNNB1
7etoposide44 50 61 1111.8CHGA, SYP, KRT8, CDH1
8crcs448.7CDKN2A, CDH1, CTNNB1
9methylcellulose448.7CTNNB1, CDH1, KRT18
10doxycycline44 119.7KRT18, NOTCH1, CDKN2A, CTNNB1
11p002448.7CHGA, KRT18, CDH1, CTNNB1
12cyclic amp44 249.6CDH1, CDKN2A, NKX2-1, SYP, CHGA
13egcg448.4CTNNB1, CDH1, CDKN2A, KRT18
14bromodeoxyuridine448.4TP63, CHGA, KRT8, KRT18, CTNNB1
15mg 13244 619.4KRT18, CDKN2A, CDH1, CTNNB1
16dopamine44 28 24 1111.4CHGA, SYP, KRT18, CDKN2A, CTNNB1
17adriamycin448.4KRT8, CDKN2A, CDH1, CTNNB1
18b 723448.4TP63, CHGA, SYP, NKX2-1, KRT8, CDH1
19retinoid448.4KRT8, KRT18, CDH1, CTNNB1
205fluorouracil448.3KRT18, CDKN2A, CDH1, CTNNB1
21creatinine448.3CHGA, SYP, KRT8, KRT18, CDKN2A, CDH1
22lipid448.2CHGA, SYP, KRT8, KRT18, NOTCH1, CDKN2A
23phosphotyrosine448.2CTNNB1, CDH1, KRT8, SYP
24n acetylcysteine448.1CTNNB1, CDH1, CDKN2A, KRT18
25paclitaxel44 50 1110.1CHGA, KRT8, CDKN2A, CDH1, CTNNB1
26agar448.1KRT8, KRT18, CDKN2A, CDH1, CTNNB1
27butyrate448.1CTNNB1, CDH1, CDKN2A, KRT18, KRT8
28sucrose44 24 1110.0CHGA, SYP, KRT8, KRT18, CDH1, CTNNB1
29oligonucleotide448.0CHGA, NKX2-1, KRT8, KRT18, CDKN2A, CTNNB1
30aspartate447.9CTNNB1, CDH1, CDKN2A, NOTCH1, KRT18
31threonine447.9NKX2-1, KRT8, KRT18, NOTCH1, CDKN2A, CTNNB1
32genistein44 28 61 2 24 1112.7SYP, KRT8, NOTCH1, CDKN2A, CDH1, CTNNB1
33cysteine447.7CHGA, SYP, KRT8, CDKN2A, CDH1, CTNNB1
34glycogen44 248.6CHGA, SYP, KRT8, KRT18, NOTCH1, CDH1
35hematoxylin447.5TP63, CHGA, SYP, NKX2-1, KRT8, KRT18
36glutamate447.4TP63, CHGA, SYP, KRT18, NOTCH1, CDH1
37matrigel447.4TP63, CHGA, KRT8, KRT18, NOTCH1, CDH1
38cisplatin44 50 61 1110.4TP63, CHGA, SYP, KRT8, CDKN2A, CDH1
39paraffin447.3CTNNB1, TP63, CDKN2A, KRT18, KRT8, NKX2-1
40steroid447.3TP63, CHGA, SYP, NKX2-1, KRT8, KRT18
41doxorubicin44 50 119.2TP63, KRT8, KRT18, NOTCH1, CDKN2A, CDH1
42dexamethasone44 50 28 1110.1CHGA, SYP, NKX2-1, KRT18, NOTCH1, CDKN2A
43calcium44 50 24 1110.0TP63, CHGA, SYP, KRT8, NOTCH1, CDKN2A
44testosterone44 61 24 1110.0TP63, CHGA, SYP, KRT8, KRT18, CDKN2A
45serine446.7CHGA, SYP, NKX2-1, KRT8, KRT18, NOTCH1
46tyrosine446.7TP63, CHGA, SYP, NKX2-1, KRT8, KRT18
47progesterone44 28 61 24 1110.7TP63, CHGA, SYP, NKX2-1, KRT8, KRT18
48vegf446.6TP63, CHGA, SYP, KRT8, KRT18, NOTCH1
49retinoic acid44 247.2CDH1, CDKN2A, NOTCH1, KRT18, KRT8, NKX2-1
50estrogen446.2TP63, CTNNB1, CDH1, CDKN2A, NOTCH1, KRT18

GO Terms for genes affiliated with Neuroendocrine Carcinoma

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Cellular components related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.1CTNNB1, CDH1
2lateral plasma membraneGO:0163289.0CTNNB1, CDH1
3cell-cell adherens junctionGO:0059138.9CDH1, CTNNB1
4transcription factor complexGO:0056678.8CTNNB1, NKX2-1, TP63
5cytoplasmic side of plasma membraneGO:0098988.7CTNNB1, CDH1
6perinuclear region of cytoplasmGO:0484718.4CHGA, KRT18, CDH1, CTNNB1
7nucleoplasmGO:0056547.5CTNNB1, TP63, NKX2-1, KRT8, NOTCH1, CDKN2A

Biological processes related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1hepatocyte apoptotic processGO:09728410.0KRT18, KRT8
2endoderm developmentGO:0074929.9NOTCH1, NKX2-1
3tumor necrosis factor-mediated signaling pathwayGO:0332099.8KRT8, KRT18
4somatic stem cell divisionGO:0481039.8CDKN2A, NOTCH1
5pituitary gland developmentGO:0219839.7CDH1, NKX2-1
6extrinsic apoptotic signaling pathwayGO:0971919.6KRT18, KRT8
7epithelial tube branching involved in lung morphogenesisGO:0604419.6NKX2-1, CTNNB1
8negative regulation of oligodendrocyte differentiationGO:0487159.5CTNNB1, NOTCH1
9cell fate specificationGO:0017089.5CTNNB1, NOTCH1
10regulation of protein localization to cell surfaceGO:20000089.4CDH1, CTNNB1
11proximal/distal pattern formationGO:0099549.4TP63, CTNNB1
12cellular response to indole-3-methanolGO:0716819.4CDH1, CTNNB1
13embryonic hindlimb morphogenesisGO:0351169.3CTNNB1, NOTCH1
14epithelial to mesenchymal transitionGO:0018379.3CTNNB1, NOTCH1
15positive regulation of mesenchymal cell proliferationGO:0020539.1TP63, CTNNB1
16cellular component disassembly involved in execution phase of apoptosisGO:0069219.0CTNNB1, CDH1
17hair follicle morphogenesisGO:0310699.0TP63, NOTCH1, CTNNB1
18embryonic limb morphogenesisGO:0303268.8CTNNB1, TP63
19negative regulation of transcription from RNA polymerase II promoterGO:0001228.6CTNNB1, NOTCH1, NKX2-1, TP63
20negative regulation of transcription, DNA-templatedGO:0458928.4TP63, NOTCH1, CDKN2A, CTNNB1
21positive regulation of transcription from RNA polymerase II promoterGO:0459448.1CTNNB1, CDKN2A, NOTCH1, NKX2-1, TP63
22positive regulation of transcription, DNA-templatedGO:0458937.5CTNNB1, CDH1, CDKN2A, NOTCH1, NKX2-1, TP63

Molecular functions related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.7KRT18, KRT8
2protein complex bindingGO:0324038.9CTNNB1, KRT8, SYP
3transcription regulatory region DNA bindingGO:0442128.9CTNNB1, NKX2-1, TP63
4structural molecule activityGO:0051988.8KRT8, KRT18, CTNNB1
5protein bindingGO:0055156.1TP63, NKX2-1, KRT8, KRT18, NOTCH1, CDKN2A

Products for genes affiliated with Neuroendocrine Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
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