MCID: NRN001
MIFTS: 50

Neuroendocrine Carcinoma malady

Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Neuroendocrine Carcinoma

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Neuroendocrine Carcinoma, Aliases & Descriptions:

Name: Neuroendocrine Carcinoma 9 11
 
Carcinoma, Neuroendocrine 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:1800
MeSH33 D018278
SNOMED-CT55 253000007, 55937004
NCIt38 C3773

Summaries for Neuroendocrine Carcinoma

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Disease Ontology:9 A carcinoma that derives from neuroendocrine cells.

MalaCards based summary: Neuroendocrine Carcinoma, also known as carcinoma, neuroendocrine, is related to merkel cell carcinoma and neuroendocrine tumor. An important gene associated with Neuroendocrine Carcinoma is GPR112 (G protein-coupled receptor 112), and among its related pathways are Cytoskeleton remodeling Keratin filaments and TP53 network. The compounds mucicarmine and silver have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and cervix, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Related Diseases for Neuroendocrine Carcinoma

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Diseases related to Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1merkel cell carcinoma31.3NKX2-1, SYP, CHGA
2neuroendocrine tumor31.2CHGA
3islet cell tumor30.6CHGA, SYP
4large cell carcinoma30.4TP63, CHGA, NKX2-1, SYP
5paraganglioma30.4CHGA, SYP
6lung cancer30.4CHGA, NKX2-1, SYP, TP63, KRT18
7cervical squamous cell carcinoma30.3CDKN2A, TP63, KRT8
8pleomorphic adenoma30.3TP63, KRT18
9adenosquamous carcinoma30.2TP63, CHGA, NKX2-1, KRT8
10basal cell carcinoma30.2KRT8, TP63, CTNNB1
11retinoblastoma30.1KRT18, SYP, CDKN2A
12cholangiocarcinoma30.1KRT18, CDH1, KRT8
13breast cancer29.9NOTCH1, CTNNB1, CDH1
14pancreatic cancer29.9KRT8, CDH1, CDKN2A
15tubular adenocarcinoma29.7TP63, CHGA, SYP, CDH1, CTNNB1
16adenocarcinoma29.2NKX2-1, KRT18, TP63, CHGA, CTNNB1, CDKN2A
17small cell cancer of the lung, somatic29.2CHGA, TP63, KRT8, NKX2-1, SYP, KRT18
18prostate cancer29.2CDH1, KRT18, TP63, CHGA, KRT8, NOTCH1
19hepatocellular carcinoma29.1NKX2-1, KRT8, CDKN2A, CTNNB1, CDH1, KRT18
20adenoma28.7TP63, KRT8, NKX2-1, SYP, CHGA, CTNNB1
21melanoma28.6CTNNB1, TP63, NKX2-1, KRT18, NOTCH1, CDKN2A
22large cell neuroendocrine carcinoma11.2
23small cell neuroendocrine carcinoma11.0
24pulmonary large cell neuroendocrine carcinoma10.8
25prostatitis10.7
26pancreatitis10.6
27thymic neuroendocrine carcinoma10.6
28neuroendocrine carcinoma of the cervix10.6
29small cell carcinoma10.6
30hepatitis10.6
31pulmonary blastoma10.5NKX2-1
32primary hepatic neuroendocrine carcinoma10.5
33thyroiditis10.5
34dysembryoplastic neuroepithelial tumor10.5SYP
35cushing's syndrome10.5
36cervicitis10.5
37ovarian large-cell neuroendocrine carcinoma10.5
38leukoplakia10.4KRT8
39actinic keratosis10.4TP63
40sinusitis10.4
41laryngitis10.4
42teratoma10.4
43central neurocytoma10.4CHGA, SYP
44endocrine gland cancer10.4CHGA, SYP
45pineocytoma10.4CHGA, SYP
46lung combined large cell neuroendocrine carcinoma10.3
47urinary bladder small cell neuroendocrine carcinoma10.3
48cervical large cell neuroendocrine carcinoma10.3
49ganglioglioma10.3SYP, CHGA
50gastrinoma10.3CHGA, SYP

Graphical network of the top 20 diseases related to Neuroendocrine Carcinoma:



Diseases related to neuroendocrine carcinoma

Symptoms for Neuroendocrine Carcinoma

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Drugs & Therapeutics for Neuroendocrine Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Neuroendocrine Carcinoma

Search NIH Clinical Center for Neuroendocrine Carcinoma

Genetic Tests for Neuroendocrine Carcinoma

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Anatomical Context for Neuroendocrine Carcinoma

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MalaCards organs/tissues related to Neuroendocrine Carcinoma:

31
Lung, Breast, Cervix, Prostate, Colon, Pancreas, Skin, Liver, Lymph node, Thyroid, Ovary, Thymus, Kidney, Brain, Adrenal gland, Testis, Endothelial, Bone, Heart, Small intestine, Salivary gland, Tonsil, Tongue, Appendix, Bronchial epithelium

Animal Models for Neuroendocrine Carcinoma or affiliated genes

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Publications for Neuroendocrine Carcinoma

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Articles related to Neuroendocrine Carcinoma:

(show top 50)    (show all 759)
idTitleAuthorsYear
1
Large Cell Neuroendocrine Carcinoma of the Nasopharynx: A Pediatric Case. (25851554)
2015
2
p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. (25512615)
2015
3
Primary neuroendocrine carcinoma of male breast: A cytologically diagnosed rare entity. (25210242)
2014
4
Cutaneous metastasis from pulmonary large cell neuroendocrine carcinoma in the scalp. (24966991)
2014
5
Treatment options for patients with large cell neuroendocrine carcinoma of the lung. (24719260)
2014
6
Impact of histological subtype on long-term outcomes of neuroendocrine carcinoma of the breast. (25399232)
2014
7
Solid neuroendocrine carcinoma of the breast: a rare tumor. (24984553)
2014
8
Metastatic small cell neuroendocrine carcinoma of the pelvic floor. (24065309)
2013
9
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of large cell neuroendocrine carcinoma of the gallbladder and common bile duct: report of a case. (22623519)
2013
10
Multimodality therapy for large cell neuroendocrine carcinoma of the thymus. (24088498)
2013
11
A rare breast tumor: solid neuroendocrine carcinoma. (22672972)
2013
12
Primary neuroendocrine carcinoma of ocular adnexa. (24294530)
2013
13
Mixed large cell neuroendocrine carcinoma with squamous cell carcinoma of the rectum: Report of a rare case and review of the literature. (24240071)
2013
14
Mammary neuroendocrine carcinoma with mucinous differentiation: a clinicopathological study of 15 cases. (24004514)
2013
15
Primary cutaneous neuroendocrine carcinoma, Merkel cell carcinoma. Case series 1991-2012. (24094946)
2013
16
Neuroendocrine carcinoma of the extrahepatic bile duct: case report and literature review. (23901240)
2013
17
Treatment of poorly differentiated neuroendocrine carcinoma of the pancreas. (23846932)
2013
18
Paranasal sinus neuroendocrine carcinoma: a case report and review of the literature. (23476846)
2013
19
Ectopic adrenalcorticotropic hormone syndrome improved by transarterial embolization to hepatic metastatic lesions of pancreatic neuroendocrine carcinoma: a case report. (23071243)
2012
20
Late recurrence of a seminoma of the testis with a poorly differentiated neuroendocrine carcinoma component. (22084429)
2012
21
Ten years survival with excellent outcome after living donor liver transplantation from 70 years old donor for primary hepatic neuroendocrine carcinoma: Case report. (22288038)
2012
22
Metastatic 5-mm rectal neuroendocrine carcinoma. (21664197)
2011
23
Refractory gastroesophageal variceal bleeding secondary to neuroendocrine carcinoma in the pancreatic tail. (21577041)
2011
24
A phase II trial of imatinib mesylate in merkel cell carcinoma (neuroendocrine carcinoma of the skin): A Southwest Oncology Group study (S0331). (20019577)
2010
25
Primary neuroendocrine carcinoma coexisting with hemangioma in the liver: report of a case. (20107963)
2010
26
Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum. (20162505)
2010
27
Neuroendocrine Carcinoma of the Bladder. (20740160)
2010
28
Diffuse pancreatic serous cystadenoma associated with neuroendocrine carcinoma: a case report and review of literature. (19129617)
2009
29
Glucose transporter-1 in pulmonary neuroendocrine carcinomas: expression and survival analysis. (19234439)
2009
30
Large-cell neuroendocrine carcinoma of the kidney: Clinicopathologic features. (19672368)
2009
31
Expression of Notch-1 and alteration of the E-cadherin/beta-catenin cell adhesion complex are observed in primary cutaneous neuroendocrine carcinoma (Merkel cell carcinoma). (19396152)
2009
32
Primary neuroendocrine carcinoma of the breast. (19136787)
2009
33
Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate. (19125417)
2009
34
Combined primary neuroendocrine carcinoma and hepatocellular carcinoma of the liver. (19686999)
2009
35
Postirradiated neuroendocrine carcinoma of the sinonasal tract. (18520182)
2008
36
Small cell carcinomas and large cell neuroendocrine carcinomas of the endometrium and cervix: polypoid tumors and those arising in polyps may have a favorable prognosis. (18580310)
2008
37
Neuroendocrine carcinoma of the breast. Our experience and a proposal of a therapeutic algorithm for a rare tumor]. (18507954)
2008
38
Neuroendocrine carcinoma metastatic to the breast. (18248556)
2008
39
A case series and immunophenotypic analysis of CK20-/CK7+ primary neuroendocrine carcinoma of the skin. (18001414)
2007
40
Role of chemotherapy and the receptor tyrosine kinases KIT, PDGFRalpha, PDGFRbeta, and Met in large-cell neuroendocrine carcinoma of the lung. (16314638)
2005
41
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. (15022286)
2004
42
The prognostic role of c-kit protein expression in resected large cell neuroendocrine carcinoma of the lung. (14726070)
2004
43
A study of moderately differentiated neuroendocrine carcinomas of the larynx and an examination of non-neoplastic larynx tissue for neuroendocrine cells. (15235358)
2004
44
Primary coexistent neuroendocrine carcinoma, hepatoid adenocarcinoma, and tubular adenocarcinoma of the stomach with focal trophoblastic differentiation in metastatic lymph nodes. (12858843)
2003
45
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (11510007)
2001
46
Small cell neuroendocrine carcinoma of the thymus complicated by Cushing's syndrome. Report of a 58-year-old woman with a 3-year history of hypertension. (11261817)
2001
47
Anti-Ri-associated paraneoplastic cerebellar degeneration without opsoclonus in a patient with a neuroendocrine carcinoma of the stomach. (10826224)
2000
48
Primary hepatic carcinoid and neuroendocrine carcinoma: clinicopathological and immunohistochemical study of five cases. (10365851)
1999
49
Large cell neuroendocrine carcinoma of the lung: a histologic and immunohistochemical study of 22 cases. (9591721)
1998
50
Immunohistochemical and flow cytometric study of neuroendocrine carcinoma of the skin. (7551012)
1995

Variations for Neuroendocrine Carcinoma

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Expression for genes affiliated with Neuroendocrine Carcinoma

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Search GEO for disease gene expression data for Neuroendocrine Carcinoma.

Pathways for genes affiliated with Neuroendocrine Carcinoma

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Pathways related to Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7KRT18, KRT8
2
Show member pathways
9.4CDKN2A, TP63
39.4NOTCH1, NKX2-1, SYP
49.2NOTCH1, CTNNB1
59.2CTNNB1, NOTCH1
69.1CDH1, KRT18, KRT8
79.0CTNNB1, CDH1
89.0CDH1, CTNNB1
99.0CTNNB1, CDH1
109.0CDH1, CTNNB1
119.0CTNNB1, CDH1
129.0CDH1, CTNNB1
139.0TP63, NOTCH1, CDKN2A
14
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion58
Pathogenic Escherichia coli infection36
Cytoskeleton remodeling Slit Robo signaling
8.7CTNNB1, CDH1, KRT18
158.6NOTCH1, CDH1, CTNNB1
168.6CTNNB1, CDH1, NOTCH1
178.5CTNNB1, CDH1, CDKN2A
18
Show member pathways
Signaling Pathways in Glioblastoma36
8.5CTNNB1, CDH1, CDKN2A
19
Show member pathways
7.7KRT18, NOTCH1, CDKN2A, CDH1, CTNNB1

Compounds for genes affiliated with Neuroendocrine Carcinoma

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Compounds related to Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1mucicarmine439.6TP63, NKX2-1, SYP
2silver439.1SYP, CHGA, CDH1, CDKN2A
3forskolin43 49 1211.0KRT18, SYP, CHGA, NKX2-1, KRT8
4gold439.0KRT8, SYP, CHGA, CDKN2A, KRT18
5formaldehyde43 249.9CDH1, NKX2-1, SYP, KRT18, CHGA
6sodium bisulfite438.9CTNNB1, CDH1, CDKN2A
7etoposide43 49 59 1211.8CHGA, KRT8, CDH1, SYP
8crcs438.7CDKN2A, CDH1, CTNNB1
9methylcellulose438.7CTNNB1, CDH1, KRT18
10doxycycline43 129.7NOTCH1, CDKN2A, KRT18, CTNNB1
11p002438.7KRT18, CDH1, CTNNB1, CHGA
12cyclic amp43 249.6CDKN2A, CHGA, CDH1, SYP, NKX2-1
13egcg438.4CDKN2A, KRT18, CDH1, CTNNB1
14bromodeoxyuridine438.4TP63, KRT18, KRT8, CHGA, CTNNB1
15mg 13243 599.4KRT18, CDKN2A, CDH1, CTNNB1
16dopamine43 28 24 1211.4SYP, KRT18, CTNNB1, CHGA, CDKN2A
17adriamycin438.4KRT8, CDKN2A, CDH1, CTNNB1
18b 723438.4CDH1, KRT8, NKX2-1, SYP, TP63, CHGA
19retinoid438.4KRT8, CDH1, CTNNB1, KRT18
205fluorouracil438.3KRT18, CDH1, CTNNB1, CDKN2A
21creatinine438.3KRT18, CDH1, SYP, CHGA, CDKN2A, KRT8
22lipid438.2SYP, CDKN2A, KRT8, CHGA, KRT18, NOTCH1
23phosphotyrosine438.2SYP, KRT8, CTNNB1, CDH1
24n acetylcysteine438.1CDKN2A, CDH1, CTNNB1, KRT18
25paclitaxel43 49 1210.1CTNNB1, CDH1, CDKN2A, CHGA, KRT8
26agar438.1CDH1, KRT8, KRT18, CDKN2A, CTNNB1
27butyrate438.1KRT18, CTNNB1, CDH1, CDKN2A, KRT8
28sucrose43 24 1210.0CTNNB1, CDH1, KRT8, CHGA, SYP, KRT18
29oligonucleotide438.0KRT8, CDKN2A, NKX2-1, CHGA, KRT18, CTNNB1
30aspartate437.9CTNNB1, CDH1, NOTCH1, KRT18, CDKN2A
31threonine437.9NKX2-1, CTNNB1, CDKN2A, KRT8, NOTCH1, KRT18
32genistein43 28 59 2 24 1212.7CDH1, CTNNB1, SYP, KRT8, NOTCH1, CDKN2A
33cysteine437.7CDKN2A, CDH1, CTNNB1, CHGA, SYP, KRT8
34glycogen43 248.6NOTCH1, CDH1, CTNNB1, KRT18, KRT8, SYP
35hematoxylin437.5TP63, KRT18, NKX2-1, SYP, CHGA, KRT8
36glutamate437.4CHGA, SYP, KRT18, NOTCH1, CDH1, CTNNB1
37matrigel437.4CDH1, NOTCH1, KRT18, KRT8, CHGA, TP63
38cisplatin43 49 59 1210.4TP63, CDH1, CTNNB1, CDKN2A, KRT8, SYP
39paraffin437.3TP63, CHGA, CTNNB1, CDKN2A, KRT18, KRT8
40steroid437.3TP63, SYP, NKX2-1, KRT18, KRT8, CDKN2A
41doxorubicin43 49 129.2NOTCH1, CTNNB1, CDH1, KRT18, KRT8, TP63
42dexamethasone43 49 28 1210.1NOTCH1, CHGA, SYP, CTNNB1, CDH1, KRT18
43calcium43 49 24 1210.0CDH1, CDKN2A, NOTCH1, KRT8, CHGA, TP63
44testosterone43 59 24 1210.0CDH1, TP63, CDKN2A, KRT18, KRT8, SYP
45serine436.7CHGA, SYP, NKX2-1, KRT8, CTNNB1, CDH1
46tyrosine436.7NKX2-1, SYP, CHGA, KRT18, NOTCH1, CDH1
47progesterone43 28 59 24 1210.7TP63, CTNNB1, CDH1, KRT18, NKX2-1, CDKN2A
48vegf436.6CDKN2A, KRT18, CDH1, NOTCH1, KRT8, SYP
49estrogen436.2SYP, CHGA, TP63, CDKN2A, NKX2-1, KRT8
50retinoic acid43 247.2TP63, CHGA, SYP, NKX2-1, KRT8, CTNNB1

GO Terms for genes affiliated with Neuroendocrine Carcinoma

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Cellular components related to Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:00163429.1CTNNB1, CDH1
2lateral plasma membraneGO:00163289.0CTNNB1, CDH1
3cell-cell adherens junctionGO:00059138.9CDH1, CTNNB1
4transcription factor complexGO:00056678.8CTNNB1, NKX2-1, TP63
5cytoplasmic side of plasma membraneGO:00098988.7CTNNB1, CDH1
6perinuclear region of cytoplasmGO:00484718.4CHGA, KRT18, CDH1, CTNNB1
7nucleoplasmGO:00056547.5CTNNB1, TP63, NKX2-1, KRT8, NOTCH1, CDKN2A

Biological processes related to Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1hepatocyte apoptotic processGO:009728410.0KRT18, KRT8
2endoderm developmentGO:00074929.9NOTCH1, NKX2-1
3tumor necrosis factor-mediated signaling pathwayGO:00332099.8KRT8, KRT18
4somatic stem cell divisionGO:00481039.8CDKN2A, NOTCH1
5pituitary gland developmentGO:00219839.7CDH1, NKX2-1
6extrinsic apoptotic signaling pathwayGO:00971919.6KRT18, KRT8
7epithelial tube branching involved in lung morphogenesisGO:00604419.6NKX2-1, CTNNB1
8negative regulation of oligodendrocyte differentiationGO:00487159.5CTNNB1, NOTCH1
9cell fate specificationGO:00017089.5CTNNB1, NOTCH1
10regulation of protein localization to cell surfaceGO:020000089.4CDH1, CTNNB1
11proximal/distal pattern formationGO:00099549.4TP63, CTNNB1
12cellular response to indole-3-methanolGO:00716819.4CDH1, CTNNB1
13embryonic hindlimb morphogenesisGO:00351169.3CTNNB1, NOTCH1
14epithelial to mesenchymal transitionGO:00018379.3CTNNB1, NOTCH1
15positive regulation of mesenchymal cell proliferationGO:00020539.1TP63, CTNNB1
16cellular component disassembly involved in execution phase of apoptosisGO:00069219.0CTNNB1, CDH1
17hair follicle morphogenesisGO:00310699.0TP63, NOTCH1, CTNNB1
18embryonic limb morphogenesisGO:00303268.8CTNNB1, TP63
19negative regulation of transcription from RNA polymerase II promoterGO:00001228.6CTNNB1, NOTCH1, NKX2-1, TP63
20negative regulation of transcription, DNA-templatedGO:00458928.4TP63, NOTCH1, CDKN2A, CTNNB1
21positive regulation of transcription from RNA polymerase II promoterGO:00459448.1CTNNB1, CDKN2A, NOTCH1, NKX2-1, TP63
22positive regulation of transcription, DNA-templatedGO:00458937.5CTNNB1, CDH1, CDKN2A, NOTCH1, NKX2-1, TP63

Molecular functions related to Neuroendocrine Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:00971109.7KRT18, KRT8
2protein complex bindingGO:00324038.9CTNNB1, KRT8, SYP
3transcription regulatory region DNA bindingGO:00442128.9CTNNB1, NKX2-1, TP63
4structural molecule activityGO:00051988.8KRT8, KRT18, CTNNB1
5protein bindingGO:00055156.1TP63, NKX2-1, KRT8, KRT18, NOTCH1, CDKN2A

Products for genes affiliated with Neuroendocrine Carcinoma

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Sources for Neuroendocrine Carcinoma

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3CDC
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25ICD10
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