MCID: NRN001
MIFTS: 58

Neuroendocrine Carcinoma malady

Cancer diseases, Neuronal diseases categories

Summaries for Neuroendocrine Carcinoma

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A carcinoma that derives from neuroendocrine cells.

MalaCards: Neuroendocrine Carcinoma, also known as carcinoma, neuroendocrine, is related to merkel cell carcinoma and neuroendocrine tumor. An important gene associated with Neuroendocrine Carcinoma is GPR112 (G protein-coupled receptor 112), and among its related pathways are Cytoskeleton remodeling Keratin filaments and TP53 network. The compounds mucicarmine and silver have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and cervix, and related mouse phenotypes are liver/biliary system and no phenotypic analysis.

Aliases & Classifications for Neuroendocrine Carcinoma

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9Disease Ontology, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroendocrine carcinoma 9
carcinoma, neuroendocrine 63


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Disease Ontology9 DOID:1800
MeSH36 D018278
SNOMED-CT59 55937004, 253000007
NCIt41 C3773

Related Diseases for Neuroendocrine Carcinoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Neuroendocrine Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1merkel cell carcinoma31.0NKX2-1, SYP, CHGA
2neuroendocrine tumor30.7CHGA
3adenocarcinoma30.7TP63, CHGA, CTNNB1, CDH1, CDKN2A, NOTCH1
4lung cancer30.4TP63, CHGA, SYP, NKX2-1, KRT18
5large cell carcinoma30.3TP63, CHGA, SYP, NKX2-1
6basal cell carcinoma30.3TP63, KRT8, CTNNB1
7cervical squamous cell carcinoma30.2CDKN2A, KRT8, TP63
8retinoblastoma30.2CDKN2A, KRT18, SYP
9prostate cancer30.1TP63, CHGA, KRT8, KRT18, NOTCH1, CDH1
10paraganglioma30.1CHGA, SYP
11tubular adenocarcinoma30.0TP63, CHGA, SYP, CDH1, CTNNB1
12pleomorphic adenoma30.0KRT18, TP63
13thyroid medullary carcinoma30.0CHGA, NKX2-1, NOTCH1
14hepatocellular carcinoma30.0NKX2-1, KRT8, KRT18, NOTCH1, CDKN2A, CDH1
15adenoma30.0TP63, CHGA, SYP, NKX2-1, KRT8, KRT18
16lung small cell carcinoma30.0TP63, CHGA, SYP, NKX2-1, KRT8, KRT18
17cholangiocarcinoma30.0KRT8, KRT18, CDH1
18adenosquamous carcinoma30.0TP63, CHGA, NKX2-1, KRT8
19pancreatic cancer30.0KRT8, CDKN2A, CDH1
20breast cancer29.9CTNNB1, CDH1, NOTCH1
21lung adenocarcinoma29.9TP63, NKX2-1, KRT8, KRT18, CDKN2A, CDH1
22cervical cancer29.9TP63, KRT8, KRT18, NOTCH1, CDKN2A
23melanoma29.8TP63, NKX2-1, KRT8, KRT18, NOTCH1, CDKN2A
24large cell neuroendocrine carcinoma11.1
25small cell neuroendocrine carcinoma10.9
26pulmonary large cell neuroendocrine carcinoma10.7
27prostatitis10.7
28pancreatitis10.6
29cutaneous neuroendocrine carcinoma10.6
30small cell carcinoma10.6
31neuroendocrine carcinoma of the cervix10.6
32thymic neuroendocrine carcinoma10.6
33hepatitis10.6
34cushing's syndrome10.5
35thyroiditis10.5
36cervicitis10.4
37ovarian large-cell neuroendocrine carcinoma10.4
38sinusitis10.3
39teratoma10.3
40cervical large cell neuroendocrine carcinoma10.3
41duodenitis10.3
42lung combined large cell neuroendocrine carcinoma10.2
43urinary bladder small cell neuroendocrine carcinoma10.2
44breast large cell neuroendocrine carcinoma10.2
45nasopharyngitis10.2
46mucinous adenocarcinoma10.2
47laryngitis10.2
48syndrome of inappropriate antidiuretic hormone10.2
49multiple endocrine neoplasia10.2
50paraneoplastic syndromes10.2

Graphical network of the top 20 diseases related to Neuroendocrine Carcinoma:



Diseases related to neuroendocrine carcinoma

Symptoms for Neuroendocrine Carcinoma

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Drugs & Therapeutics for Neuroendocrine Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Neuroendocrine Carcinoma

Drug clinical trials:

Search ClinicalTrials for Neuroendocrine Carcinoma

Search NIH Clinical Center for Neuroendocrine Carcinoma

Search CenterWatch for Neuroendocrine Carcinoma

Genetic Tests for Neuroendocrine Carcinoma

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Anatomical Context for Neuroendocrine Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Neuroendocrine Carcinoma:

34
Lung, Breast, Cervix, Prostate, Colon, Pancreas, Skin, Liver, Lymph node, Thyroid, Thymus, Ovary, Kidney, Testis, Brain, Adrenal gland, Endothelial, Small intestine, Tongue, Salivary gland, Bone, Skeletal muscle, Heart, Appendix

Animal Models for Neuroendocrine Carcinoma or affiliated genes

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38MGI
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Publications for Neuroendocrine Carcinoma

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53PubMed
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Articles related to Neuroendocrine Carcinoma:

(show top 50)    (show all 672)
idTitleAuthorsYear
1
Prognostic Factors for Small Cell Neuroendocrine Carcinoma of the Uterine Cervix: An Institutional Experience. (24401981)
2014
2
Metastatic small cell neuroendocrine carcinoma of the pelvic floor. (24065309)
2013
3
Endoscopic ultrasound-guided fine-needle aspiration diagnosis of large cell neuroendocrine carcinoma of the gallbladder and common bile duct: report of a case. (22623519)
2013
4
Multimodality therapy for large cell neuroendocrine carcinoma of the thymus. (24088498)
2013
5
Primary neuroendocrine carcinoma of ocular adnexa. (24294530)
2013
6
Mixed large cell neuroendocrine carcinoma with squamous cell carcinoma of the rectum: Report of a rare case and review of the literature. (24240071)
2013
7
Mammary neuroendocrine carcinoma with mucinous differentiation: a clinicopathological study of 15 cases. (24004514)
2013
8
Primary cutaneous neuroendocrine carcinoma, Merkel cell carcinoma. Case series 1991-2012. (24094946)
2013
9
Neuroendocrine carcinoma of the extrahepatic bile duct: case report and literature review. (23901240)
2013
10
Treatment of poorly differentiated neuroendocrine carcinoma of the pancreas. (23846932)
2013
11
Paranasal sinus neuroendocrine carcinoma: a case report and review of the literature. (23476846)
2013
12
Large cell neuroendocrine carcinoma of female genital tract: a clinicopathological study of two cases with review of literature. (24426770)
2013
13
Advanced composite of large cell neuroendocrine carcinoma and squamous cell carcinoma: a case report of uterine cervical cancer in a virgin woman. (24062959)
2013
14
Thymic neuroendocrine carcinoma producing ectopic adrenocorticotropic hormone and Cushing's syndrome. (24088497)
2013
15
Ectopic adrenalcorticotropic hormone syndrome improved by transarterial embolization to hepatic metastatic lesions of pancreatic neuroendocrine carcinoma: a case report. (23071243)
2012
16
Late recurrence of a seminoma of the testis with a poorly differentiated neuroendocrine carcinoma component. (22084429)
2012
17
Ten years survival with excellent outcome after living donor liver transplantation from 70 years old donor for primary hepatic neuroendocrine carcinoma: Case report. (22288038)
2012
18
Large cell neuroendocrine carcinoma arising in mature cystic teratoma: a case report and review of the literature. (23091901)
2012
19
Metastatic 5-mm rectal neuroendocrine carcinoma. (21664197)
2011
20
Refractory gastroesophageal variceal bleeding secondary to neuroendocrine carcinoma in the pancreatic tail. (21577041)
2011
21
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (21415004)
2011
22
A phase II trial of imatinib mesylate in merkel cell carcinoma (neuroendocrine carcinoma of the skin): A Southwest Oncology Group study (S0331). (20019577)
2010
23
Primary neuroendocrine carcinoma coexisting with hemangioma in the liver: report of a case. (20107963)
2010
24
Ectopic Cushing's syndrome caused by a well differentiated ACTH-secreting neuroendocrine carcinoma of the ileum. (20162505)
2010
25
Neuroendocrine Carcinoma of the Bladder. (20740160)
2010
26
Diffuse pancreatic serous cystadenoma associated with neuroendocrine carcinoma: a case report and review of literature. (19129617)
2009
27
Glucose transporter-1 in pulmonary neuroendocrine carcinomas: expression and survival analysis. (19234439)
2009
28
Large-cell neuroendocrine carcinoma of the kidney: Clinicopathologic features. (19672368)
2009
29
Expression of Notch-1 and alteration of the E-cadherin/beta-catenin cell adhesion complex are observed in primary cutaneous neuroendocrine carcinoma (Merkel cell carcinoma). (19396152)
2009
30
Primary neuroendocrine carcinoma of the breast. (19136787)
2009
31
Shared TP53 gene mutation in morphologically and phenotypically distinct concurrent primary small cell neuroendocrine carcinoma and adenocarcinoma of the prostate. (19125417)
2009
32
Combined primary neuroendocrine carcinoma and hepatocellular carcinoma of the liver. (19686999)
2009
33
Primary small cell neuroendocrine carcinoma of the nasal cavity after successful curative therapy of nasopharyngeal carcinoma: a case report. (19419920)
2009
34
Postirradiated neuroendocrine carcinoma of the sinonasal tract. (18520182)
2008
35
Small cell carcinomas and large cell neuroendocrine carcinomas of the endometrium and cervix: polypoid tumors and those arising in polyps may have a favorable prognosis. (18580310)
2008
36
Neuroendocrine carcinoma of the breast. Our experience and a proposal of a therapeutic algorithm for a rare tumor]. (18507954)
2008
37
Neuroendocrine carcinoma metastatic to the breast. (18248556)
2008
38
Fine-needle aspiration cytology of large cell neuroendocrine carcinoma of the lung: a cytohistologic correlation study of 11 cases. (18433011)
2008
39
Moderately differentiated neuroendocrine carcinoma of the larynx. (19434271)
2008
40
A case series and immunophenotypic analysis of CK20-/CK7+ primary neuroendocrine carcinoma of the skin. (18001414)
2007
41
Role of chemotherapy and the receptor tyrosine kinases KIT, PDGFRalpha, PDGFRbeta, and Met in large-cell neuroendocrine carcinoma of the lung. (16314638)
2005
42
Genetic alterations in early-stage pulmonary large cell neuroendocrine carcinoma. (15022286)
2004
43
The prognostic role of c-kit protein expression in resected large cell neuroendocrine carcinoma of the lung. (14726070)
2004
44
A study of moderately differentiated neuroendocrine carcinomas of the larynx and an examination of non-neoplastic larynx tissue for neuroendocrine cells. (15235358)
2004
45
Primary coexistent neuroendocrine carcinoma, hepatoid adenocarcinoma, and tubular adenocarcinoma of the stomach with focal trophoblastic differentiation in metastatic lymph nodes. (12858843)
2003
46
Combined large cell neuroendocrine carcinoma and spindle cell carcinoma of the lung. (11510007)
2001
47
Small cell neuroendocrine carcinoma of the thymus complicated by Cushing's syndrome. Report of a 58-year-old woman with a 3-year history of hypertension. (11261817)
2001
48
Primary hepatic carcinoid and neuroendocrine carcinoma: clinicopathological and immunohistochemical study of five cases. (10365851)
1999
49
Large cell neuroendocrine carcinoma of the lung: a histologic and immunohistochemical study of 22 cases. (9591721)
1998
50
Immunohistochemical and flow cytometric study of neuroendocrine carcinoma of the skin. (7551012)
1995

Variations for Neuroendocrine Carcinoma

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Expression for genes affiliated with Neuroendocrine Carcinoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroendocrine Carcinoma

Search GEO for disease gene expression data for Neuroendocrine Carcinoma.

Pathways for genes affiliated with Neuroendocrine Carcinoma

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Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 5Cell Signaling Technology, 31KEGG, 13EMD Millipore, 54QIAGEN
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Pathways related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7KRT8, KRT18
2
Show member pathways
9.4TP63, CDKN2A
39.4SYP, NKX2-1, NOTCH1
49.2NOTCH1, CTNNB1
59.2NOTCH1, CTNNB1
69.1KRT8, CDH1, KRT18
79.0CTNNB1, CDH1
89.0CDH1, CTNNB1
99.0CTNNB1, CDH1
109.0CTNNB1, CDH1
119.0CTNNB1, CDH1
129.0CDH1, CTNNB1
139.0NOTCH1, TP63, CDKN2A
14
Show member pathways
Neurophysiological process Receptor mediated axon growth repulsion61
Pathogenic Escherichia coli infection39
8.7KRT18, CTNNB1, CDH1
158.6CDH1, CTNNB1, NOTCH1
168.6CDH1, CTNNB1, NOTCH1
178.5CDKN2A, CTNNB1, CDH1
18
Show member pathways
Signaling Pathways in Glioblastoma39
8.5CTNNB1, CDH1, CDKN2A
19
Show member pathways
7.7KRT18, NOTCH1, CDH1, CTNNB1, CDKN2A

Compounds for genes affiliated with Neuroendocrine Carcinoma

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB
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Compounds related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show top 50)    (show all 100)
idCompoundScoreTop Affiliating Genes
1mucicarmine469.6TP63, NKX2-1, SYP
2silver469.1SYP, CHGA, CDH1, CDKN2A
3forskolin46 52 1211.0KRT18, SYP, CHGA, NKX2-1, KRT8
4gold469.0KRT8, SYP, CHGA, CDKN2A, KRT18
5formaldehyde46 259.9CDH1, NKX2-1, SYP, KRT18, CHGA
6sodium bisulfite468.9CTNNB1, CDH1, CDKN2A
7etoposide46 52 62 1211.8CHGA, KRT8, CDH1, SYP
8crcs468.7CDKN2A, CDH1, CTNNB1
9methylcellulose468.7CTNNB1, CDH1, KRT18
10doxycycline46 129.7NOTCH1, CDKN2A, KRT18, CTNNB1
11p002468.7KRT18, CDH1, CTNNB1, CHGA
12cyclic amp46 259.6CDKN2A, CHGA, CDH1, SYP, NKX2-1
13egcg468.4CDKN2A, KRT18, CDH1, CTNNB1
14bromodeoxyuridine468.4TP63, KRT18, KRT8, CHGA, CTNNB1
15mg 13246 629.4KRT18, CDKN2A, CDH1, CTNNB1
16dopamine46 30 25 1211.4SYP, KRT18, CTNNB1, CHGA, CDKN2A
17adriamycin468.4KRT8, CDKN2A, CDH1, CTNNB1
18b 723468.4CDH1, KRT8, NKX2-1, SYP, TP63, CHGA
19retinoid468.4KRT8, CDH1, CTNNB1, KRT18
205fluorouracil468.3KRT18, CDH1, CTNNB1, CDKN2A
21creatinine468.3KRT18, CDH1, SYP, CHGA, CDKN2A, KRT8
22lipid468.2SYP, CDKN2A, KRT8, CHGA, KRT18, NOTCH1
23phosphotyrosine468.2SYP, KRT8, CTNNB1, CDH1
24n acetylcysteine468.1CDKN2A, CDH1, CTNNB1, KRT18
25paclitaxel46 52 1210.1CTNNB1, CDH1, CDKN2A, CHGA, KRT8
26agar468.1CDH1, KRT8, KRT18, CDKN2A, CTNNB1
27butyrate468.1KRT18, CTNNB1, CDH1, CDKN2A, KRT8
28sucrose46 25 1210.0CTNNB1, CDH1, KRT8, CHGA, SYP, KRT18
29oligonucleotide468.0KRT8, CDKN2A, NKX2-1, CHGA, KRT18, CTNNB1
30aspartate467.9CTNNB1, CDH1, NOTCH1, KRT18, CDKN2A
31threonine467.9NKX2-1, CTNNB1, CDKN2A, KRT8, NOTCH1, KRT18
32genistein46 30 62 3 25 1212.7CDH1, CTNNB1, SYP, KRT8, NOTCH1, CDKN2A
33cysteine467.7CDKN2A, CDH1, CTNNB1, CHGA, SYP, KRT8
34glycogen46 258.6NOTCH1, CDH1, CTNNB1, KRT18, KRT8, SYP
35hematoxylin467.5TP63, KRT18, NKX2-1, SYP, CHGA, KRT8
36glutamate467.4CHGA, SYP, KRT18, NOTCH1, CDH1, CTNNB1
37matrigel467.4CDH1, NOTCH1, KRT18, KRT8, CHGA, TP63
38cisplatin46 52 62 1210.4TP63, CDH1, CTNNB1, CDKN2A, KRT8, SYP
39paraffin467.3TP63, CHGA, CTNNB1, CDKN2A, KRT18, KRT8
40steroid467.3TP63, SYP, NKX2-1, KRT18, KRT8, CDKN2A
41doxorubicin46 52 129.2NOTCH1, CTNNB1, CDH1, KRT18, KRT8, TP63
42dexamethasone46 52 30 1210.1NOTCH1, CHGA, SYP, CTNNB1, CDH1, KRT18
43calcium46 52 25 1210.0CDH1, CDKN2A, NOTCH1, KRT8, CHGA, TP63
44testosterone46 62 25 1210.0CDH1, TP63, CDKN2A, KRT18, KRT8, SYP
45serine466.7CHGA, SYP, NKX2-1, KRT8, CTNNB1, CDH1
46tyrosine466.7NKX2-1, SYP, CHGA, KRT18, NOTCH1, CDH1
47progesterone46 30 62 25 1210.7TP63, CTNNB1, CDH1, KRT18, NKX2-1, CDKN2A
48vegf466.6CDKN2A, KRT18, CDH1, NOTCH1, KRT8, SYP
49estrogen466.2SYP, CHGA, TP63, CDKN2A, NKX2-1, KRT8
50retinoic acid46 257.2TP63, CHGA, SYP, NKX2-1, KRT8, CTNNB1

GO Terms for genes affiliated with Neuroendocrine Carcinoma

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17Gene Ontology
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Cellular components related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catenin complexGO:0163429.1CTNNB1, CDH1
2lateral plasma membraneGO:0163289.0CTNNB1, CDH1
3cell-cell adherens junctionGO:0059138.9CDH1, CTNNB1
4transcription factor complexGO:0056678.8CTNNB1, NKX2-1, TP63
5cytoplasmic side of plasma membraneGO:0098988.7CTNNB1, CDH1
6perinuclear region of cytoplasmGO:0484718.4CHGA, KRT18, CDH1, CTNNB1
7nucleoplasmGO:0056547.5CTNNB1, TP63, NKX2-1, KRT8, NOTCH1, CDKN2A

Biological processes related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1hepatocyte apoptotic processGO:09728410.0KRT18, KRT8
2endoderm developmentGO:0074929.9NOTCH1, NKX2-1
3tumor necrosis factor-mediated signaling pathwayGO:0332099.8KRT8, KRT18
4somatic stem cell divisionGO:0481039.8CDKN2A, NOTCH1
5pituitary gland developmentGO:0219839.7CDH1, NKX2-1
6extrinsic apoptotic signaling pathwayGO:0971919.6KRT18, KRT8
7epithelial tube branching involved in lung morphogenesisGO:0604419.6NKX2-1, CTNNB1
8negative regulation of oligodendrocyte differentiationGO:0487159.5CTNNB1, NOTCH1
9cell fate specificationGO:0017089.5CTNNB1, NOTCH1
10regulation of protein localization to cell surfaceGO:20000089.4CDH1, CTNNB1
11proximal/distal pattern formationGO:0099549.4TP63, CTNNB1
12cellular response to indole-3-methanolGO:0716819.4CDH1, CTNNB1
13embryonic hindlimb morphogenesisGO:0351169.3CTNNB1, NOTCH1
14epithelial to mesenchymal transitionGO:0018379.3CTNNB1, NOTCH1
15positive regulation of mesenchymal cell proliferationGO:0020539.1TP63, CTNNB1
16cellular component disassembly involved in execution phase of apoptosisGO:0069219.0CTNNB1, CDH1
17hair follicle morphogenesisGO:0310699.0TP63, NOTCH1, CTNNB1
18embryonic limb morphogenesisGO:0303268.8CTNNB1, TP63
19negative regulation of transcription from RNA polymerase II promoterGO:0001228.6CTNNB1, NOTCH1, NKX2-1, TP63
20negative regulation of transcription, DNA-templatedGO:0458928.4TP63, NOTCH1, CDKN2A, CTNNB1
21positive regulation of transcription from RNA polymerase II promoterGO:0459448.1CTNNB1, CDKN2A, NOTCH1, NKX2-1, TP63
22positive regulation of transcription, DNA-templatedGO:0458937.5CTNNB1, CDH1, CDKN2A, NOTCH1, NKX2-1, TP63

Molecular functions related to Neuroendocrine Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1scaffold protein bindingGO:0971109.7KRT18, KRT8
2protein complex bindingGO:0324038.9CTNNB1, KRT8, SYP
3transcription regulatory region DNA bindingGO:0442128.9CTNNB1, NKX2-1, TP63
4structural molecule activityGO:0051988.8KRT8, KRT18, CTNNB1
5protein bindingGO:0055156.1TP63, NKX2-1, KRT8, KRT18, NOTCH1, CDKN2A

Products for genes affiliated with Neuroendocrine Carcinoma

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Sources for Neuroendocrine Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet