MCID: NRN004
MIFTS: 61

Neuroendocrine Tumor malady

Neuronal diseases, Cancer diseases categories

Summaries for Neuroendocrine Tumor

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63Wikipedia, 32MalaCards
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Wikipedia:63 Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous... more...

MalaCards: Neuroendocrine Tumor, also known as neuroendocrine tumors, is related to pancreatitis and neuroendocrine carcinoma. An important gene associated with Neuroendocrine Tumor is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Neuroscience. The compounds tyrosine and vegf have been mentioned in the context of this disorder. Affiliated tissues include lung, pancreas and liver, and related mouse phenotypes are nervous system and homeostasis/metabolism.

Aliases & Classifications for Neuroendocrine Tumor

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10DISEASES, 8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroendocrine tumor 8 10
neuroendocrine tumors 44 60
neuroendocrine carcinoma 10
carcinoma neuroendocrine 44
neuroendocrine neoplasm 8


External Ids:

Disease Ontology8 DOID:169
ICD9CM27 209-209.99, 209
MeSH34 D018358
NCIt39 C3809

Related Diseases for Neuroendocrine Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Neuroendocrine Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 358)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.5SST
2neuroendocrine carcinoma31.0CHGA, GRP, SST, CDX2, ENO2, ASCL1
3thyroiditis30.7CALCA
4von hippel-lindau disease30.7MEN1
5duodenitis30.6GAST
6adenocarcinoma30.5SYP, NKX2-1, GHRL, MEN1, GAST, CCNB1
7paraganglioma30.5ENO2, SST, SSTR2, GRP, CALCA, GAST
8pheochromocytoma30.5ENO2, ASCL1, CDX2, SST, SSTR2, CALCA
9gastrinoma30.4CHGA, GRP, SSTR2, SST, ENO2, SYP
10cushing's syndrome30.4CALCA, MEN1, GHRL, SYP, CHGA, SST
11acromegaly30.4MEN1, GHRL, SSTR2, SST, GGH
12hypercalcemia30.4CHGA, MEN1, GAST, CALCA
13adenoma30.4CHGB, SSTR2, SST, MKI67, CDX2, GGH
14thyroid medullary carcinoma30.4GAST, MEN1, GHRL, NKX2-1, CHGA, CHGB
15thyroid cancer30.4CCNB1, CALCA, NKX2-1
16lung small cell carcinoma30.3CHGA, GRP, SSTR2, SST, INSM1, ENO2
17pituitary adenoma30.3MEN1, GHRL, SYP, CHGA, CHGB, SSTR2
18hypoglycemia30.3SST, CHGA, GHRL, GAST
19non-small cell lung carcinoma30.2NKX2-1, SYP, CHGA, GRP, ENO2
20insulinoma30.2CALCA, GAST, MEN1, GHRL, CHGA, GRP
21prostate cancer30.2CCNB1, CHGA, CHGB, GRP, MKI67, CDX2
22retinoblastoma30.2CCNB1, MEN1, SYP, MKI67, ENO2
23neurofibromatosis30.2ENO2, SST, MEN1
24pancreas disease30.2GAST
25islet cell tumor30.2SST, GAST
26melanoma30.1CCNB1, GHRL, NKX2-1, GRP, SSTR2, MKI67
27papillary carcinoma30.1CALCA, NKX2-1, SYP, CHGA, SSTR2, MKI67
28tubular adenocarcinoma30.1SYP, CHGA, CDX2, ENO2
29adenosquamous carcinoma30.1GRP, CHGA, NKX2-1
30hepatocellular carcinoma30.1CCNB1, MEN1, GHRL, NKX2-1, GRP, SSTR2
31lung cancer30.1NKX2-1, SYP, CHGA, GRP, CDX2, ENO2
32diarrhea30.1CPE, SST, CHGA, GAST, CALCA
33pancreatic cancer30.1CDX2, SST, SSTR2, GAST
34gastritis30.1GAST, GHRL, CDX2
35neuroblastoma30.1SYP, ENO2
36gastrointestinal stromal tumor30.1ENO2, MKI67
37acinar cell carcinoma30.1CHGA, GAST
38gastroduodenitis29.9GAST
39breast cancer29.9CCNB1, CALCA, MEN1, GRP, SSTR2, MKI67
40prolactinoma29.9SST, SSTR2, CHGB, CHGA, MEN1
41esophagitis29.9CDX2, GAST
42endometrial carcinoma29.9CCNB1, NKX2-1, MKI67
43barrett's esophagus29.9GAST, MKI67, CDX2
44cholangiocarcinoma29.9CDX2, CCNB1
45thymoma29.9NKX2-1
46parathyroid carcinoma29.9MEN1
47hypertension29.9CALCA
48bladder adenocarcinoma29.9CDX2
49olfactory neuroblastoma29.9SYP, ENO2
50squamous cell carcinoma29.9CCNB1, NKX2-1, SYP, CHGA, GRP, MKI67

Graphical network of the top 20 diseases related to Neuroendocrine Tumor:



Diseases related to neuroendocrine tumor

Clinical Features for Neuroendocrine Tumor

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Drugs & Therapeutics for Neuroendocrine Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neuroendocrine Tumor

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Anatomical Context for Neuroendocrine Tumor

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32MalaCards
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MalaCards organs/tissues related to Neuroendocrine Tumor:

32
Lung, Pancreas, Liver, Prostate, Thyroid, Breast, Pituitary, Small intestine, Cervix, Kidney, Bone, Endothelial, Lymph node, Spleen, Thymus, Colon, Testes, Pancreatic islet, Brain, Appendix, Ovary, Testis, Heart, Adrenal gland, Spinal cord, Smooth muscle, Pineal, Bone marrow

Animal Models for Neuroendocrine Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuroendocrine Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.3MEN1, NKX2-1, NKX2-2, SYP, CHGB, SSTR2
2MP:000537611.0CALCA, GAST, MEN1, GHRL, NKX2-2, CHGB
3MP:000537911.0CPE, GAST, MEN1, CHGB, CDX2, INSM1
4MP:000538110.8GAST, MEN1, GHRL, NKX2-1, SSTR2, SST

Publications for Neuroendocrine Tumor

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50PubMed
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Articles related to Neuroendocrine Tumor:

(show top 50)    (show all 985)
idTitleAuthorsYear
1
Humoral hypercalcemia of malignancy caused by parathyroid hormone-related peptide-secreting neuroendocrine tumors. Report of six cases. (23719609)
2013
2
Nonfunctional neuroendocrine tumor of the pancreas: Case report and review of the literature. (23287065)
2013
3
Pancreatic neuroendocrine tumor with cystlike changes: evaluation with MDCT. (23436873)
2013
4
Elevated Ki-67 labeling index in 'synchronous liver metastases' of well differentiated enteropancreatic neuroendocrine tumor. (24274715)
2013
5
Usual and unusual neuroendocrine tumor metastases on (68)Ga-DOTANOC PET/CT: a pictorial review. (23235484)
2013
6
Deficiency of the macrophage growth factor CSF-1 disrupts pancreatic neuroendocrine tumor development. (21822305)
2012
7
Pancreatic neuroendocrine tumor: added value of fusion of T2-weighted imaging and high b-value diffusion-weighted imaging for tumor detection. (22386133)
2012
8
Spindle cell typical carcinoid tumor (well-differentiated neuroendocrine carcinoma) diagnosed by electromagnetic navigation bronchoscopy with cytologic rapid on-site evaluation. (21987437)
2012
9
11C-5-hydroxytryptophan positron emission tomography after radiofrequency ablation of neuroendocrine tumor liver metastases. (22381780)
2012
10
Gastroenteropancreatic neuroendocrine tumor cancer stem cells: do they exist? (22105614)
2012
11
Later diagnosed with a neuroendocrine tumor, case report of a 60-year-old. (23099981)
2012
12
A case of pancreatic neuroendocrine tumor in a patient with neurofibromatosis-1. (22824559)
2012
13
Double neuroendocrine ductal carcinomas in situ coexisting with a background of diffuse idiopathic neuroendocrine cell hyperplasia of breast: a case report and hypothesis of neuroendocrine tumor development. (22524661)
2012
14
Advances in pancreatic neuroendocrine tumor treatment. (21561358)
2011
15
Concomitant Nonfunctional Pancreatic Neuroendocrine Tumor and Gastric GIST in a Patient Without Neurofibromatosis Type 1. (22083533)
2011
16
Anti-vascular endothelial growth factor antibody single therapy for pancreatic neuroendocrine carcinoma exhibits a marked tumor growth-inhibitory effect. (22977618)
2011
17
The North American Neuroendocrine Tumor Society (NANETS) guidelines: mission, goals, and process. (20664469)
2010
18
Dual role of RASSF1 as a tumor suppressor and an oncogene in neuroendocrine tumors of the lung. (21036752)
2010
19
Role of somatostatins in gastroenteropancreatic neuroendocrine tumor development and therapy. (20637207)
2010
20
Treatment with tandem [(90)Y]DOTA-TATE and [(177)Lu] DOTA-TATE of neuroendocrine tumors refractory to conventional therapy: preliminary results. (20168290)
2010
21
Primary neuroendocrine tumor of the sacrum: case report and review of the literature. (19360403)
2009
22
The effect of transforming growth factor beta on human neuroendocrine tumor BON cell proliferation and differentiation is mediated through somatostatin signaling. (18567806)
2008
23
Somatostatin-producing neuroendocrine tumors of the duodenum and pancreas: incidence, types, biological behavior, association with inherited syndromes, and functional activity. (18310290)
2008
24
Non-functioning well-differentiated neuroendocrine tumor of the extrahepatic bile duct: an unusual suspect? (17897922)
2007
25
Chemoembolization and bland embolization of neuroendocrine tumor metastases to the liver. (17609443)
2007
26
Intestinal neuroendocrine tumor in a patient with pituitary adenoma. A case report and review of the current screening recommendations. (18021452)
2007
27
Neuroendocrine tumors secreting growth hormone-releasing hormone: Pathophysiological and clinical aspects. (17036195)
2006
28
Genes involved in neuroendocrine tumor biology. (17001466)
2006
29
Effects of the tyrosine kinase inhibitor imatinib on neuroendocrine tumor cell growth. (15785039)
2005
30
Insulinoma, a rare neuroendocrine tumor: a case report. (15751752)
2005
31
RET and neuroendocrine tumors. (15013219)
2004
32
Serotonin release during percutaneous radiofrequency ablation in a patient with symptomatic liver metastases of a neuroendocrine tumor. (15143927)
2004
33
Sertoli cell tumor of the testis (not otherwise specified) with the expression of neuroendocrine markers and without the expression of inhibin-alpha. (15363041)
2004
34
Immunohistochemical localization of endothelin-converting enzyme-1 in neuroendocrine tumors and normal human tissue. (14658484)
2003
35
Pigmented neuroendocrine tumor of the lung, showing neuromelanin. (12685551)
2002
36
Xenin-immunoreactive cells and extractable xenin in neuroendocrine tumors of duodenal origin. (12404236)
2002
37
Neuroendocrine tumors in the brain. (11762340)
2001
38
Divergent differentiation in neuroendocrine tumors of the adrenal gland. (10839612)
2000
39
Malignant Sertoli cell tumor of the ovary metastatic to the lung mimicking neuroendocrine carcinoma: report of a case. (10459047)
1999
40
Summing up 15 years of somatostatin analog therapy in neuroendocrine tumors: future outlook. (10399030)
1999
41
Malignant neuroendocrine tumor presenting a huge mediastinal mass controlled with radiation therapy. (9869108)
1998
42
Molecular alterations to human chromosome 3p loci in neuroendocrine lung tumors. (9740075)
1998
43
Mechanism of retinoblastoma gene inactivation in the spectrum of neuroendocrine lung tumors. (9476905)
1998
44
High expression of the POU factor Brn3a in aggressive neuroendocrine tumors. (8989239)
1997
45
Immunohistochemical study of 17 cases of rectal neuroendocrine tumors]. (8767675)
1996
46
Clinical efficacy of octreotide in the treatment of metastatic neuroendocrine tumors. A study by the Italian Trials in Medical Oncology Group. (8625251)
1996
47
Use of long-acting somatostatin analog, lanreotide, in neuroendocrine tumors. (21607321)
1994
48
The role of interleukin-1 and tumor necrosis factor alpha in the neurochemical and neuroendocrine responses to endotoxin. (1473014)
1992
49
Serum chromogranin A in the diagnosis and follow-up of neuroendocrine tumors of the gastroenteropancreatic tract. (1413839)
1992
50
Epithelial and neuroendocrine tumors of the duodenum. (1925122)
1991

Genetic Variations for Neuroendocrine Tumor

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Expression for genes affiliated with Neuroendocrine Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroendocrine Tumor

Search GEO for disease gene expression data for Neuroendocrine Tumor.

Pathways for genes affiliated with Neuroendocrine Tumor

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology
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Compounds for genes affiliated with Neuroendocrine Tumor

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.9SSTR2, MKI67, CDX2, ENO2, ASCL1, GRP
2vegf4411.8MKI67, CALCA, SYP, MEN1, GRP, GHRL
3octreotide44 59 28 1114.7CALCA, GAST, CHGA, GRP, SSTR2, SST
4acth4411.6SST, CALCA, GAST, GHRL, SYP, CHGA
5paraffin4411.6CDX2, CCNB1, GHRL, MKI67, NKX2-1, ENO2
6thymidine44 2412.6GRP, CCNB1, MEN1, GHRL, SSTR2, MKI67
7calcium44 49 11 2414.6CCNB1, GAST, MEN1, SYP, CHGA, CHGB
8norepinephrine44 11 2413.6ENO2, CHGB, GRP, SST, SYP, GHRL
9adenylate4411.5CALCA, GAST, GRP, GHRL, SST, SSTR2
10testosterone44 59 11 2414.5GRP, SST, MKI67, CHGA, GAST, ENO2
11dopamine44 28 11 2414.5GAST, ENO2, CPE, SSTR2, GRP, GHRL
125-hydroxytryptamine4411.5ENO2, SST, CALCA, GHRL, SYP, CHGA
13gnrh4411.5NKX2-1, CHGA, GRP, SSTR2, SST, MKI67
14histamine44 28 2413.5SSTR2, CALCA, GAST, GRP, GHRL, SST
15acetylcholine44 49 28 11 2415.5SYP, CHGA, GRP, CALCA, ENO2, SST
16lactate4411.4CALCA, ENO2, GGH, MKI67, SST, GRP
17cisplatin44 49 59 1114.4CHGA, GAST, GRP, SYP, MKI67, ENO2
18serine4411.4CPE, CHGB, SYP, CCNB1, MEN1, GHRL
19retinoic acid44 2412.4ASCL1, NKX2-1, CCNB1, ENO2, MKI67, SST
20gaba4411.4GRP, CHGA, SST, GAST, GHRL, SYP
21epinephrine44 11 2413.4CALCA, MKI67, GRP, CHGA, GHRL, GAST
22progesterone44 59 28 11 2415.4NKX2-1, CHGA, MKI67, CDX2, ENO2, CCNB1
23111in-pentetreotide4411.3SSTR2, SST, CALCA, SYP, CHGA
24peptidylglycine4411.3CHGB, GRP, CPE, CHGA, GAST
25forskolin44 49 1113.3SSTR2, CALCA, ENO2, CPE, NKX2-1
26oxyntomodulin44 5912.3GHRL, SST, GRP, CHGA, GAST
27spec-t4411.2CALCA, SST, SSTR2, GRP, ENO2
28glucose4411.2GAST, GHRL, SSTR2, CPE, CCNB1
29dexamethasone44 49 28 1114.2ENO2, CHGB, GRP, NKX2-1, GHRL
30hematoxylin4411.2ENO2, NKX2-1, SYP, MKI67, CHGA
31c-peptide4411.2CPE, SST, CHGA, GHRL, GAST
32propranolol44 28 49 11 2415.2GRP, CALCA, GAST, CHGA, SST
33mibg4411.1CALCA, ENO2, CHGA, SST
34atropine44 28 1113.1GRP, GAST, CALCA, GHRL
35glutamate4411.1GHRL, CPE, GAST
36pirenzepine44 28 1113.1GAST, GRP, GHRL, SST
37dtpa4411.1GRP, SSTR2, GAST, SST
385-hydroxyindoleacetic acid44 2412.1ENO2, SST, CHGA, GAST
39creatinine4411.0GRP, GAST, GHRL, SYP, CHGA
40hydrocortisone44 2 59 1114.0SST, GAST, CALCA, GRP, GHRL
41guanine44 11 2413.0SSTR2, CALCA, GRP
42lafutidine4410.9GAST, SST, CALCA
43vitamin d4410.9CALCA, CHGA, GHRL, CDX2, GAST, MEN1
44smcc4410.9SYP, CHGA, ENO2
45nifedipine44 49 28 1113.9GAST, GHRL, GRP, SST, CHGA
46minigastrin4410.9SST, GRP, GAST
47loxiglumide4410.8GAST, SST, GRP
48bromodeoxyuridine4410.7GAST, CCNB1, ENO2, MKI67, CHGA
49pepsinogen4410.7GRP, GAST, CHGA
50carbachol44 28 1112.5GAST, GHRL, CHGA, GRP, SST

GO Terms for genes affiliated with Neuroendocrine Tumor

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16Gene Ontology
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Cellular components related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.1CPE, SST, GRP, CHGB, CHGA, GHRL

Biological processes related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex GABAergic interneuron differentiationGO:02189210.7ASCL1, NKX2-1
2spinal cord oligodendrocyte cell fate specificationGO:02153010.6ASCL1, NKX2-2
3neuron fate specificationGO:04866510.6ASCL1, NKX2-2
4type B pancreatic cell developmentGO:00332310.5NKX2-2, INSM1
5neuropeptide signaling pathwayGO:00721810.4CPE, GRP, CALCA

Molecular functions related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.8SST, CHGB, GAST, CALCA

Products for genes affiliated with Neuroendocrine Tumor

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Sources for Neuroendocrine Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet