Neuroendocrine Tumor malady

Wikipedia: Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous...⁴⁴ more...

MalaCards: Neuroendocrine Tumor, also known as neuroendocrine tumors, is related to pulmonary neuroendocrine tumor and gastrointestinal neuroendocrine tumor. An important gene associated with Neuroendocrine Tumor is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Signal transduction_PTEN pathway and Colorectal cancer. The compounds tetrodotoxin and c-peptide have been mentioned in the context of this disorder. Affiliated tissues include lymph node, thymus and brain, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

Aliases & Descriptions:

neuroendocrine tumor 6 8 neuroendocrine tumors 32 43 neuroendocrine tumor (disorder) 6

endocrine gland neoplasms 43 neuroendocrine neoplasm 6

Diseases related to neuroendocrine tumor by text searches and GeneDecks gene sharing:

(show top 50)    (show all 900)

id	Related Disease	Score	Top Affiliating Genes
1	pulmonary neuroendocrine tumor	36.2	RB1, CHGA, FSCN1, CDH2, CDKN2A, CDH1
2	gastrointestinal neuroendocrine tumor	34.9	VEGFA, CHGA, CD44, MKI67, ENO2, GHRL
3	intestinal neuroendocrine tumor	34.0	CHGA, CDX2, TPH1, SST
4	endocrine gland cancer	33.9	RET, GCG, VIP, CHGA, IAPP, GNAS
5	multiple endocrine neoplasia	30.5	RET, CNC, GCG, VIP, SDHD, SCT
6	somatostatinoma	30.2	GCG, VIP, CHGA, MEN1, ENO2, CALCA
7	vipoma	30.2	VIP, SCT, CHGA, MEN1, CALCA, GH1
8	cushing's syndrome	29.9	RET, CNC, CHGA, AVPR1B, INS, MEN1
9	carcinoid syndrome	29.8	VIP, VEGFA, CHGA, MEN1, ENO2, IGF1
10	neurofibromatosis	29.5	RET, KIT, RAF1, SDHD, S100B, MEN1
11	pancreatic islet cell tumors	29.4	CEACAM3, PTHLH, SST, GAST
12	acromegaly	29.4	CNC, GCG, VIP, VEGFA, CHGA, CDKN1B
13	merkel cell carcinoma	29.2	KIT, CHGA, MUC1, ENO2, MAPK10, SST
14	paraganglioma	29.1	RET, KIT, VIP, BCL2, SDHAF2, SDHD
15	squamous cell carcinoma	29.1	CD44, CDH1, MKI67, CCND1, PTHLH, KRT19
16	pancreatic ductal carcinoma	28.9	VEGFA, MUC1, CDKN2A, TP53, NTS, KRT20
17	sclerosing hemangioma	28.7	RB1, CHGA, MUC1, CEACAM3, CDKN2A, CDH1
18	gastrinoma	28.6	GCG, VIP, SCT, CHGA, CDKN2A, INS
19	carcinoid tumors	28.5	RET, GCG, VIP, RAF1, RASSF1, CLDN4
20	hemangioma of lung	28.3	RB1, MUC1, CEACAM3, CDKN2A, CALCA, ERBB2
21	pancreatic endocrine tumors	28.2	GCG, VIP, BCL2, CHGB, CHGA, MTA1
22	hypercalcemia	28.0	SCT, CHGA, MEN1, IL2, IL6, CCND1
23	hypoglycemia	28.0	GCG, VEGFA, SCT, CHGA, INS, MEN1
24	pancreatic cancer	28.0	RET, GCG, VIP, VEGFA, RAF1, BIRC5
25	hemangioma	27.9	RET, RB1, VEGFA, SDHAF2, SDHD, CHGA
26	mediastinitis	27.7	KIT, SDHD, CEACAM3, IL6, ENO2, CCNE1
27	neuroepithelioma	27.4	RET, CD99, GRP, ENO2, MAPK10, MAPK1
28	small cell carcinoma	26.9	KIT, RB1, VIP, VEGFA, RASSF1, BCL2
29	pheochromocytoma	26.4	RET, KIT, VIP, VEGFA, RAF1, BIRC5
30	differentiating neuroblastoma	26.2	RET, BCL2, CHGA, ASCL1, IL6, MAPK1
31	duodenitis	25.0	KIT, GCG, VIP, BRAF, BCL2, SCT
32	lung carcinoma	24.9	PIK3CA, RB1, BRAF, VEGFA, RAF1, RASSF1
33	pituitary adenoma	24.4	RET, CNC, KIT, RB1, VIP, BRAF
34	choroiditis	23.2	VIP, BRAF, VEGFA, RAF1, RASSF1, BIRC5
35	pancreatitis	23.1	PIK3CA, RET, KIT, GCG, RB1, VIP
36	carcinoma	22.1	ZNF410, PIK3CA, PDCD4, RET, CNC, KIT
37	thyroid carcinoma	22.0	PIK3CA, RET, RB1, BRAF, VEGFA, RAF1
38	thyroiditis	21.7	PIK3CA, RET, CNC, KIT, GCG, RB1
39	prostate carcinoma	20.7	RB1, BRAF, VEGFA, VCL, RASSF1, BIRC5
40	pancreatic carcinoma	20.6	PIK3CA, RET, RB1, VIP, VEGFA, RAF1
41	retinoblastoma	20.5	PIK3CA, KIT, RB1, VIP, VEGFA, RAF1
42	neuronitis	19.3	PIK3CA, RET, KIT, GCG, RB1, VIP
43	neuroblastoma	18.9	PIK3CA, RET, KIT, RB1, VIP, VEGFA
44	prostatitis	18.8	PIK3CA, PDCD4, RET, KIT, RB1, VIP
45	adenocarcinoma	18.6	PIK3CA, RET, KIT, GCG, RB1, VIP
46	adenoma	18.5	ZNF410, PIK3CA, PDCD4, RET, CNC, KIT
47	fibrosis	17.6	PIK3CA, KIT, VIP, VEGFA, BIRC5, BCL2
48	hepatitis	16.9	PIK3CA, KIT, GCG, RB1, VIP, BRAF
49	neuroendocrine carcinoma	14.6	KIT, GCG, SCG2, CHGA, MUC1, S100B
50	familial medullary thyroid carcinoma	14.5	RET, CHGA, MKI67, GRP, ENO2, CALCA

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to neuroendocrine tumor:

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MGI Mouse Phenotypes related to neuroendocrine tumor:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	RET, ATOH1, ITGB3, ASCL1, INSM1, CALCA
2	endocrine/exocrine gland phenotype	MP:0005379	10.4	PDCD4, RET, AVPR1B, ATOH1, CDKN1B, CDC25C
3	craniofacial phenotype	MP:0005382	9.8	KIT, BAMBI, L1CAM, ASCL1, INSM1, FGF9
4	taste/olfaction phenotype	MP:0005394	9.6	INSM1, ENO2, MAPK1, CASP3, DRD2, TERT
5	hematopoietic system phenotype	MP:0005397	9.6	KIT, BRAF, BCL2, BCL2L1, JUND, APC
6	normal phenotype	MP:0002873	9.4	RET, VIP, BRAF, VEGFA, SDHD, BAMBI
7	limbs/digits/tail phenotype	MP:0005371	9.0	RET, KIT, RB1, VEGFA, VCL, BAMBI
8	pigmentation phenotype	MP:0001186	8.7	KIT, RB1, BRAF, BCL2, L1CAM, CDKN1B
9	no phenotypic analysis	MP:0003012	8.6	RET, RB1, VEGFA, MUC1, L1CAM, ATOH1
10	renal/urinary system phenotype	MP:0005367	8.4	PDCD4, RET, KIT, BRAF, BCL2, CHGA
11	embryogenesis phenotype	MP:0005380	8.3	PIK3CA, RET, KIT, BRAF, VCL, RAF1
12	hearing/vestibular/ear phenotype	MP:0005377	8.3	KIT, RB1, BCL2, BAX, ATOH1, CDKN1B
13	liver/biliary system phenotype	MP:0005370	8.2	KIT, VEGFA, JUND, INS, MEN1, MET
14	immune system phenotype	MP:0005387	8.1	PDCD4, KIT, BRAF, RAF1, MTOR, JUND
15	digestive/alimentary phenotype	MP:0005381	7.9	RET, KIT, GCG, RB1, BRAF, VEGFA
16	integument phenotype	MP:0010771	7.8	KIT, RB1, BRAF, RAF1, BCL2, BCL2L1
17	nervous system phenotype	MP:0003631	7.3	KIT, RB1, BRAF, VCL, RAF1, BCL2L1
18	behavior/neurological phenotype	MP:0005386	7.3	PIK3CA, KIT, RB1, VIP, BRAF, SCT
19	adipose tissue phenotype	MP:0005375	7.2	PIK3CA, RB1, BRAF, BCL2, MTOR, CDKN1B
20	mortality/aging	MP:0010768	7.2	PIK3CA, PDCD4, RET, GCG, RB1, BRAF
21	reproductive system phenotype	MP:0005389	7.0	PIK3CA, PDCD4, RET, VIP, VEGFA, L1CAM
22	skeleton phenotype	MP:0005390	6.1	KIT, RB1, BRAF, VEGFA, RAF1, BAMBI
23	vision/eye phenotype	MP:0005391	5.4	PIK3CA, KIT, RB1, BRAF, VEGFA, RAF1
24	muscle phenotype	MP:0005369	5.1	PIK3CA, RET, KIT, RB1, BRAF, VEGFA
25	tumorigenesis	MP:0002006	5.1	PIK3CA, PDCD4, RET, KIT, RB1, BRAF
26	homeostasis/metabolism phenotype	MP:0005376	4.4	PIK3CA, RET, KIT, GCG, RB1, VIP
27	cardiovascular system phenotype	MP:0005385	3.7	PIK3CA, RET, KIT, RB1, BRAF, VEGFA
28	growth/size phenotype	MP:0005378	3.3	PIK3CA, RET, KIT, GCG, RB1, BRAF
29	cellular phenotype	MP:0005384	3.0	PIK3CA, RET, KIT, RB1, BRAF, VEGFA

Articles related to neuroendocrine tumor:

(show top 50)    (show all 313)

id	Title	Authors	Year	Affiliating Genes
1	Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors. (21245995)	Kuiper P.... Verspaget H.W.	2011	VEGFA, ENG
2	Serum and ascites chromogranin-A in patients with met astatic neuroendocrine tumors. (21483253)	Warner R.R.... Kim M.K.	2011	CHGA
3	Peptide receptor radionuclide therapy in patients wit h gastroenteropancreatic neuroendocrine tumors. (20113677)	Kwekkeboom D.J.... Krenning E.P.	2010	SST
4	18F-fluorodeoxyglucose positron emission tomography p redicts survival of patients with neuroendocrine tumors. (20103666)	Binderup T.... Kjaer A.	2010	CHGA
5	Neuroendocrine tumors of the ampulla of Vater: biolog ical behavior and surgical management. (19528385)	Carter J.T.... Way L.W.	2009	VIP
6	Is it time to widen the use of somatostatin analogs i n neuroendocrine tumors? (19704053)	Oberg K.E.	2009	SST
7	IL-6-174 C/G polymorphism in the gastroenteropancreatic neuroendocrine tumors (GEP-NETs). (17950274)	Berkovic M.C.... Kapitanovic S.	2007	IL6
8	Chromogranin A: is it a useful marker of neuroendocrine tumors? (17513802)	Campana D.... Tomassetti P.	2007	CHGA
9	CK19 and CD99 immunoexpression profile in goblet cell (mucin-producing neuroendocrine tumors) and classical carcinoids of the vermiform appendix. (17652531)	Alsaad K.O.... Chetty R.	2007	KRT19, CD99
10	The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors? (16428931)	Kunnimalaiyaan M.... Chen H.	2006	RAF1
11	Clinicopathologic characteristics of colorectal neuroendocrine tumor (16929153)	Jung S.H.... Kim J.C.	2006	SYP, CHGA
12	Neuroendocrine tumors of the gastrointestinal tract: recent advances in molecular genetics, diagnosis, and treatment. (15933475)	Oberg K.	2005	GNAS
13	The radionuclide molecular imaging and therapy of neuroendocrine tumors. (15810878)	Li S.... Beheshti M.	2005	ANXA5
14	Alteration of the E-cadherin/beta-catenin cell adhesion system is common in pulmonary neuroendocrine tumors and is an independent predictor of lymph node metastasis in atypical carcinoids. (15712207)	Pelosi G.... Viale G.	2005	CDH1, CTNNB1, FSCN1
15	Accuracy and clinical correlates of two different methods for chromogranin A assay in neuroendocrine tumors. (15646836)	Ferrari L.... Bombardieri E.	2004	CHGA
16	Consensus report on the use of somatostatin analogs for the management of neuroendocrine tumors of the gastroenteropancreatic system. (15151956)	Oberg K.... Wiedenmann B.	2004	SST
17	CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors. (15316316)	Barbareschi M.... Doglioni C.	2004	CDX2
18	RET and neuroendocrine tumors. (15013219)	Ichihara M.... Takahashi M.	2004	RET, MAPK1, MAPK8
19	Neuroendocrine tumor markers and enterochromaffin-like cell hyper/dysplasia in type 1 diabetes. (15161793)	De Block C.E.... Van Gaal L.F.	2004	ENO2, CHGA, GAST
20	Programmed cell death protein 4 (PDCD4) acts as a tumor suppressor in neuroendocrine tumor cells. (15153438)	Goke R.... Lankat-Buttgereit B.	2004	CA2, PDCD4
21	Divergent cyclin B1 expression and Rb/p16/cyclin D1 pathway aberrations among pulmonary neuroendocrine tumors. (15154011)	Igarashi T.... Okayasu I.	2004	RB1, CCND1, CCNB1
22	Diagnostic value of tumor M2-pyruvate kinase in neuroendocrine tumors. A comparative study with chromogranin A. (12926146)	Pezzilli R.... Corinaldesi R.	2003	CHGA
23	Immunohistochemical localization of endothelin-converting enzyme-1 in neuroendocrine tumors and normal human tissue. (14658484)	Hsu Y.H.... Huang S.C.	2003	ECE1
24	Pancreatic neuroendocrine tumor with extensive vascularisation and parathyroid hormone-related protein (PTHrP)--associated hypercalcemia of malignancy. (11573150)	Clemens P.... Lamberts R.	2001	PTHLH
25	Chromogranin A in human neuroendocrine tumors: an imm unohistochemical study with region-specific antibodies. (11688460)	Portel-Gomes G.M.... Stridsberg M.	2001	CHGA
26	CCK receptors in human neuroendocrine tumors: clinical implications. (11713969)	Reubi J.C.	2001	CCKBR, GAST
27	A Phase II study of high-dose paclitaxel in patients with advanced neuroendocrine tumors. (11301403)	Ansell S.M.... Rubin J.	2001	CSF3
28	Neuroendocrine tumors in the brain. (11762340)	Cavalla P.... Schiffer D.	2001	SST
29	Hypercalcitoninemia in a sporadic asymptomatic neuroendocrine tumor of the pancreatic tail. (11124561)	Machens A.... Dralle H.	2000	CALCA
30	Choroidal metastasis as the initial manifestation of a pigmented neuroendocrine tumor. (10865324)	Eagle R.C.... Shields C.L.	2000	CALCA, SYP
31	Differential retinoblastoma and p16(INK4A) protein expression in neuroendocrine tumors of the lung. (10649246)	Dosaka-Akita H.... Benedict W.F.	2000	RB1, CDKN2A
32	New molecular aspects in the diagnosis and therapy of neuroendocrine tumors of the gastroenteropancreatic system. (10626288)	Pape U.F.... Wiedenmann B.	2000	SST
33	Endoscopic ultrasound is highly accurate and directs management in patients with neuroendocrine tumors of the pancreas. (11007228)	Anderson M.A.... Scheiman J.M.	2000	SCT
34	Levels and molecular properties of secretoneurin-immunoreactivity in the serum and urine of control and neuroendocrine tumor patients. (10634410)	Ischia R.... Winkler H.	2000	CHGA, SCG2
35	Somatostatin analogues in diagnosis and management of neuroendocrine tumors (10723232)	Nalewajka-KoA8odziejczak J.	1999	SST
36	Treatment with high dose [(111)In-DTPA-D-PHE1]-octreotide in patients with neuroendocrine tumors--evaluation of therapeutic and toxic effects. (10380830)	Tiensuu Janson E.... Westlin J.E.	1999	SST
37	The relationship between MIB-1 proliferation index and outcome in pancreatic neuroendocrine tumors. (9495200)	Gentil Perret A.... Boucheron S.	1998	MKI67
38	Plasma chromogranin A in prostatic carcinoma and neuroendocrine tumors. (8996358)	Kimura N.... Nagura H.	1997	CHGA
39	Familial neuroendocrine tumors as a model of hereditary cancer. (9090493)	Anderson R.J.... Lynch H.T.	1997	RET
40	Induction of apoptosis in neuroendocrine tumors of the digestive system during treatment with somatostatin analogs. (9408151)	Imam H.... Oberg K.	1997	SST
41	Tissue-specific expression of human achaete-scute homologue-1 in neuroendocrine tumors: transcriptional regulation by dual inhibitory regions. (9186001)	Chen H.... Ball D.W.	1997	ASCL1
42	Drug therapy in metastatic neuroendocrine tumors of the gastroenteropancreatic system. (8893342)	Faiss S.... Wiedenmann B.	1996	SST
43	Tyrosine hydroxylase indicates cell differentiation of catecholamine biosynthesis in neuroendocrine tumors. (7523477)	Iwase K.... Kishikawa T.	1994	TH, ENO2
44	Immunogold detection of chromogranin A in the neuroendocrine tumor. (8427030)	Silver M.M.... Hearn S.S.	1993	CHGA
45	Medical treatment of neuroendocrine tumors. (8171735)	Bajetta E.... Bochicchio A.M.	1993	SST
46	Detection of functional interferon alpha receptors in human neuroendocrine tumor cell lines using a new monoclonal antibody. (1316782)	Rosolen A.... Neckers L.M.	1992	IFNA1
47	Abnormal p53 expression in lung neuroendocrine tumors. Diagnostic and prognostic implications. (1364172)	Roncalli M.... Viale G.	1992	TP53
48	Somatostatin-producing neuroendocrine tumor of the ampulla (ampullary somatostatinoma). Evidence of prosomatostatin production. (1371903)	Sawady J.... Aron D.C.	1992	SST
49	Argyrophilic carcinoma of the male breast. A neuroendocrine tumor containing predominantly chromogranin B (secretogranin I). (1928556)	Scopsi L.... Rilke F.	1991	CHGB
50	Determination of plasma calcitonin gene-related peptide concentrations by a new immunochemiluminometric assay in normal persons and patients with medullary thyroid carcinoma and other neuroendocrine tumors. (1991803)	Carter W.B.... Heath H.	1991	CALCA

Genes related to neuroendocrine tumor according to GeneCards:

(show top 50)    (show all 196)

id	Symbol	Description	Score	GeneCards Section Context
1	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications
2	SST	somatostatin	11.0	Publications
3	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
4	ASCL1	achaete-scute complex homolog 1 (Drosophila)	11.0	Publications
5	GGH	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)	11.0	Publications
6	GRP	gastrin-releasing peptide	11.0	Publications
7	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
8	NKX2-1	NK2 homeobox 1	11.0	Publications
9	CDX2	caudal type homeobox 2	11.0	Publications
10	CCNB1	cyclin B1	11.0	Publications
11	GHRL	ghrelin/obestatin prepropeptide	11.0	Publications
12	CPE	carboxypeptidase E	11.0	Publications
13	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
14	INSM1	insulinoma-associated 1	11.0	Functions, Publications
15	NKX2-2	NK2 homeobox 2	11.0	Publications
16	CHGB	chromogranin B (secretogranin 1)	11.0	Publications
17	MEN1	multiple endocrine neoplasia I	11.0	Publications
18	DLK1	delta-like 1 homolog (Drosophila)	11.0	Publications
19	SSTR2	somatostatin receptor 2	11.0	Publications
20	SRPX	sushi-repeat containing protein, X-linked	11.0	Publications
21	SCG2	secretogranin II	11.0	Publications
22	SYP	synaptophysin	11.0	Publications
23	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	11.0	Publications
24	GAST	gastrin	11.0	Publications
25	GHSR	growth hormone secretagogue receptor	11.0	Publications
26	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	11.0	Publications
27	GRPR	gastrin-releasing peptide receptor	11.0	Publications
28	HDC	histidine decarboxylase	11.0	Publications
29	VIP	vasoactive intestinal peptide	11.0	Publications
30	ADCYAP1	adenylate cyclase activating polypeptide 1 (pituitary)	11.0	Publications
31	TPH1	tryptophan hydroxylase 1	11.0	Publications
32	CCKBR	cholecystokinin B receptor	11.0	Publications
33	SOCS1	suppressor of cytokine signaling 1	11.0	Publications
34	SLC6A2	solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2	11.0	Publications
35	TRAF3	TNF receptor-associated factor 3	11.0	Publications
36	NTS	neurotensin	11.0	Publications
37	SLC18A2	solute carrier family 18 (vesicular monoamine), member 2	11.0	Publications
38	TAC1	tachykinin, precursor 1	11.0	Publications
39	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0	Publications
40	IFI27	interferon, alpha-inducible protein 27	11.0	Publications
41	PSG2	pregnancy specific beta-1-glycoprotein 2	11.0	Publications
42	TJP1	tight junction protein 1	11.0	Publications
43	GDNF	glial cell derived neurotrophic factor	11.0	Publications
44	SCT	secretin	11.0	Publications
45	CEACAM3	carcinoembryonic antigen-related cell adhesion molecule 3	11.0	Publications
46	GAL	galanin prepropeptide	11.0	Publications
47	KRT20	keratin 20	11.0	Publications
48	KRT19	keratin 19	11.0	Publications
49	RET	ret proto-oncogene	11.0	Publications
50	CCK	cholecystokinin	11.0	Publications

Pathways related to neuroendocrine tumor according to GeneDecks:

(show top 50)    (show all 250)

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction_PTEN pathway41	10.8	TSC2, IGF1R
2	Colorectal cancer20	10.5	SMAD3, MAPK8, BRAF
3	Signal transduction_AKT signaling41	9.9	CDKN1B, CCND1, IGF1R, TP53, PTEN, MTOR
4	Breast Cancer Regulation by Stathmin136	9.6	NRP2, EGFR, ADCY2, TEK, ERBB2, GHRH
5	Bladder cancer20	9.6	RASSF1, RAF1, VEGFA, BRAF, RB1, EGFR
6	Transcription Receptor-mediated HIF regulation10	9.5	MAPK1, INS, RAF1, IGF1R, IGF1, TSC2
7	Signal transduction PTEN pathway10	9.4	IGF1, MAPK1, MTOR, RAF1, PIK3CA, PTEN
8	Glioma20	9.4	PIK3CA, RB1, EGFR, PTEN, TP53, IGF1
9	Glioblastoma Multiforme36	9.3	EGFR, TSC2, RB1, MAPK1, TP53, BRAF
10	Melanoma20	9.3	PTEN, TP53, IGF1, IGF1R, CCND1, MAPK1
11	Development IGF-RI signaling10	9.2	RAF1, MAPK1, CCND1, MTOR, IGF1R, BCL2L1
12	Transcription_Receptor-mediated HIF regulation41	9.2	TSC2, RPS6KB1, PIK3CA, PTEN, VEGFA, RAF1
13	Development_IGF-1 receptor signaling41	9.1	PIK3CA, RAF1, MTOR, BCL2L1, MAPK1, CCND1
14	Regulation of eIF4 and p70S6K36	9.1	IL6, RPS6KB1, IL2, ITGB3, MAPK14, BAX
15	Akt Signaling36	9.0	IGF1R, TNF, TEK, CTGF, TSC2, CCND1
16	Endometrial cancer20	9.0	RAF1, CTNNB1, EGFR, PIK3CA, CTNNA1, PTEN
17	Small cell lung cancer20	9.0	PTEN, ITGAV, TP53, BCL2L1, CCNE1, CCND1
18	TGF-beta Signaling Pathways37	8.8	JUND, RPS6KB1, MAPK10, MAPK1, NFKB1, MTOR
19	JNK Pathway36	8.7	TP53, IL6, ANGPT1, RAF1, TEK, DAXX
20	Progesterone-mediated oocyte maturation20	8.7	MAPK1, MAPK10, MAPK8, INS, MAPK14, RAF1
21	PTEN Pathway36	8.4	IGF1R, PTEN, MET, BRAF, KIT, CTGF
22	Mitochondrial Apoptosis36	8.3	KIT, BCL2, BCL2L1, BAX, CDKN2A, EGFR
23	14-3-3 Induced Intracellular Signaling36	8.3	MAPK8, MAPK10, MAPK1, IGF1R, IGF1, GH1
24	Ras Pathway36	8.3	KIT, BRAF, EGFR, CTGF, TEK, GHRH
25	Rac1 Pathway36	8.3	MET, RAF1, ITGAV, ITGB3, IL2, IL6
26	p53 Mediated Apoptosis36	8.2	GH1, IGF1R, GHRH, PTEN, TP53, EGFR
27	Focal adhesion20	8.0	CTNNB1, MAPK8, CCND1, MAPK10, MAPK1, ITGAV
28	Prostate cancer20	8.0	NFKB1, PIK3CA, RB1, BRAF, CTNNB1, PTEN
29	Hepatitis C20	7.7	TP53, PIK3CA, BRAF, RAF1, IFNA2, MAPK8
30	Cellular Apoptosis Pathway36	7.6	IGF1, TNF, EGFR, GH1, IL2, MET
31	Pathways in cancer20	7.5	SLC2A1, EGFR, CTNNB1, CTNNA1, PTEN, PTCH1
32	ERK Signaling36	7.5	ERBB2, ADCY2, ECM1, CSF3, EGFR, NFKB1
33	ILK Signaling36	7.4	KIT, GH1, IGF1, IGF1R, MAPK1, MAPK10
34	Endothelin-1 Signaling Pathway36	7.4	KIT, BRAF, RAF1, IL2, IL6, ANGPT1
35	PPAR Pathway36	7.3	ITGB3, IL2, KIT, RAF1, ITGAV, MET
36	Molecular Mechanisms of Cancer36	7.2	BCL2, BCL2L1, BAX, CDKN1B, CDKN2A, CDH1
37	Colorectal Cancer Metastasis36	7.0	NFKB1, CCND1, ADCY2, TP53, MAPK1, APC
38	JAK-STAT Pathway36	6.8	SOCS1, PRL, EGFR, ANGPT1, MAPK1, IGF1R
39	Estrogen Pathway36	6.7	KIT, BRAF, RAF1, BCL2, MET, IL2
40	GSK3 Signaling36	6.7	MET, IL6, APC, MAPK8, MAPK1, MAPK14
41	p70S6K Signaling36	6.7	INS, MAPK8, RAF1, KIT, MET, IL2
42	Pancreatic Adenocarcinoma36	6.5	IL2, MAPK1, CCNE1, CCNB1, CCND1, IGF1R
43	GPCR Pathway36	6.5	IGF1, KIT, GH1, GHRH, ERBB2, TEK
44	p38 Signaling36	6.4	GH1, GHRH, ERBB2, TP53, TNF, TEK
45	Renin-Angiotensin Pathway36	6.4	IL6, IL2, MET, RAF1, KIT, NFKB1
46	MAPK Family Pathway36	6.4	IL2, BRAF, RAF1, BCL2, BAX, GHRH
47	PAK Pathway36	6.3	BAX, BCL2, KIT, GH1, IL6, IL2
48	Rho Family GTPases36	5.9	ANGPT2, ANGPT1, MAPK8, MAPK10, MAPK1, IGF1R
49	MAPK Signaling36	5.9	NFKB1, TNF, TEK, CTGF, ADCY2, EGFR
50	Antioxidant Action of Vitamin-C36	5.8	IGF1, GHRH, TNF, SLC2A1, CSF3, EGFR

Compounds related to neuroendocrine tumor according to GeneDecks:

(show top 50)    (show all 450)

id	Compound	Score	Top Affiliating Genes
1	tetrodotoxin32	11.0	GCG, VIP, SCT, MME, GRP, ENO2
2	c-peptide32	10.9	GCG, SCT, CCK, GHRL, PDX1, CPE
3	dopamine32 9 18 9	13.9	PIK3CA, RET, GCG, VIP, RAF1, SCG2
4	atropine32 9 9	12.9	GCG, VIP, SCT, MME, GRP, CCK
5	clonidine32 9 9	12.7	SCT, CHGA, IGF1, CALCA, GH1, GHRH
6	epinephrine32 9 18 9	13.6	GCG, VIP, SCT, CHGA, INS, GRP
7	creatinine32	10.5	GCG, CHGA, MUC1, S100B, CEACAM3, CDKN2A
8	acetylcholine32 9 18 9	13.4	GCG, VIP, VCL, RAF1, SCG2, SCT
9	glucose32	10.4	KIT, GCG, BRAF, VCL, SCG2, SCT
10	estradiol32 9 18 9	13.4	RB1, BIRC5, MUC1, MTOR, CEACAM5, CDKN1B
11	methionine32	10.3	RET, KIT, VCL, RASSF1, CHGA, S100B
12	histamine32 18	11.2	PIK3CA, KIT, GCG, VIP, RAF1, SCG2
13	octreotide32 42 9 9	13.2	GCG, VIP, VEGFA, SCT, CHGA, MME
14	gnrh32	10.2	GCG, RAF1, SCG2, CDC25C, MME, MKI67
15	agar32	9.9	PIK3CA, RET, RB1, BRAF, RASSF1, BIRC5
16	arginine32	9.8	PIK3CA, RET, GCG, VIP, BRAF, SCT
17	atp32	9.7	PIK3CA, RET, KIT, RB1, BRAF, VCL
18	2-deoxyglucose32	9.7	INS, GRP, ANXA5, MAPK10, IGF1, CALCA
19	depsipeptide32	9.7	RB1, BRAF, RAF1, BCL2, BCL2L1, BAX
20	nitric oxide32 9 18 9	12.6	KIT, RB1, VCL, BIRC5, CHGA, MUC1
21	adenylate32	9.6	PIK3CA, GCG, VIP, SCG2, SCT, CHGA
22	camptothecin32 42 9 9	12.4	RB1, BIRC5, BCL2, BCL2L1, BAX, CDKN1B
23	n acetylcysteine32	9.3	RAF1, BIRC5, CDKN1B, CDKN2A, CDH1, ANXA5
24	thymidylate32	9.3	RB1, VEGFA, BIRC5, BCL2, BCL2L1, BAX
25	testosterone32 9 18 9	12.2	PIK3CA, RET, KIT, RB1, VIP, VCL
26	cysteine32	9.2	GCG, VCL, RAF1, BCL2L1, SCG2, SCT
27	calcitriol32 42 9 18 9	13.1	RB1, CDKN1B, CD44, CDH1, GRP, IL2
28	matrigel32	9.1	PIK3CA, RB1, BRAF, VEGFA, VCL, BCL2L1
29	calcium32 9 18 9	12.0	KIT, RB1, VIP, BRAF, VCL, BIRC5
30	glycogen32 18	10.0	PIK3CA, KIT, GCG, CHGA, MTOR, S100B
31	etoposide32 42 9 9	11.9	PIK3CA, RB1, BIRC5, BCL2, BCL2L1, CHGA
32	glutamate32	8.8	PIK3CA, GCG, VIP, BRAF, L1CAM, JUND
33	taxane32	8.8	VEGFA, BIRC5, BCL2, MTOR, ESR1, ERBB2
34	methotrexate32 34 42 9 9	12.8	KIT, RB1, BIRC5, MUC1, CEACAM3, CDKN1B
35	retinoid32	8.8	BCL2, BCL2L1, BAX, CDH1, MAPK8, MAPK14
36	geldanamycin32 9 9	10.6	BRAF, VEGFA, VCL, RAF1, BIRC5, BCL2L1
37	docetaxel32 34 9 9	11.5	KIT, VEGFA, RAF1, BIRC5, BCL2, BCL2L1
38	sulforaphane32	8.4	RB1, CDC25C, MGMT, MAPK8, MAPK14, MAPK1
39	mg 13232 42	9.3	BIRC5, BCL2L1, BAX, CDKN1B, CDKN2A, CDH1
40	adriamycin32	8.2	RB1, BIRC5, BCL2, BCL2L1, MUC1, BAX
41	lactacystin32	8.2	RAF1, BIRC5, BCL2, BCL2L1, CDKN1B, CDC25C
42	alanine32	8.1	RET, GCG, VIP, BRAF, RAF1, RASSF1
43	lactate32	7.8	PIK3CA, KIT, GCG, VIP, BIRC5, CHGA
44	bortezomib32 9 9	9.6	VEGFA, BIRC5, BCL2, BCL2L1, BAX, CDKN1B
45	gemcitabine32 34 9 9	10.5	VEGFA, BIRC5, BCL2, BCL2L1, MUC1, BAX
46	oxygen32 18	8.5	RB1, BIRC5, BCL2, BCL2L1, SDHD, BAX
47	ag 147832	7.4	PIK3CA, RAF1, CDKN1B, MET, MAPK8, MAPK14
48	5fluorouracil32	7.3	PIK3CA, KIT, GCG, RB1, VEGFA, BIRC5
49	triptolide32	6.4	VEGFA, BCL2, BAX, IL2, IL6, ANXA5
50	actinomycin d32	4.9	PIK3CA, KIT, RB1, VEGFA, BIRC5, BCL2

Cellular components related to neuroendocrine tumor according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	secretory granule	GO:030141	10.5	GHRL, POMC, CPE, GAL, INS, CHGA
2	cell-cell adherens junction	GO:005913	10.4	TJP1, APC, CDH1, CDH2, VCL, CTNNB1
3	neuronal cell body	GO:043025	10.2	CALCA, SST, TAC1, SLC18A2, HDC, ALCAM
4	membrane	GO:016020	9.3	NRP2, EGFR, TSC2, STK11, SLC6A2, SLC2A1
5	extracellular region	GO:005576	9.0	NTS, CTGF, SST, PTHLH, TEK, GHRL
6	nucleoplasm	GO:005654	8.3	PLK1, SMAD3, SP1, TERT, TP53, ERCC1
7	extracellular space	GO:005615	7.4	GGH, SST, DLK1, PTHLH, TNF, HMOX1
8	cytosol	GO:005829	7.2	CTNNB1, CTNNA1, CTGF, DAXX, PTEN, TJP1
9	plasma membrane	GO:005886	7.2	SSTR3, SSTR4, SSTR5, CTGF, CTNNA1, CTNNB1
10	cytoplasm	GO:005737	6.7	DAXX, SSTR2, SSTR3, SSTR5, SP1, CTNNB1
11	nucleus	GO:005634	5.2	CTNNB1, SNAI1, SMAD3, PLK1, NOTCH1, RPS6KB1

Biological processes related to neuroendocrine tumor according to GeneDecks:

(show top 50)    (show all 64)

id	Name	GO ID	Score	Top Affiliating Genes
1	feeding behavior	GO:007631	11.0	GAL, NKX2-1, NPY, CRH, DRD2, CALCA
2	somatostatin signaling pathway	GO:038170	10.9	SSTR5, SSTR4, SSTR3, SSTR2, SSTR1
3	positive regulation of endothelial cell proliferation	GO:001938	10.7	ECM1, NF1, NRP2, TEK, HTR2B, ITGB3
4	response to estrogen stimulus	GO:043627	10.5	GAL, KRT19, CTNNA1, HMOX1, GHRL, ESR1
5	osteoblast development	GO:002076	10.5	SHH, SMAD3, PTHLH, GLI2, MEN1, JUND
6	positive regulation of multicellular organism growth	GO:040018	10.4	DRD2, GHSR, GHRL, GHRH, GH1, BCL2
7	cell migration	GO:016477	10.4	CTGF, SNAI1, RPS6KB1, PSG2, PTEN, ENG
8	negative regulation of cyclin-dependent protein kinase activity	GO:045736	10.2	PLK1, CASP3, APC, MEN1, CDKN2A, CDKN1B
9	response to ethanol	GO:045471	10.2	MGMT, CCNE1, CCND1, RPS6KB1, SHH, TH
10	cell cycle arrest	GO:007050	10.2	TSC2, SMAD3, TP53, APC, MEN1, CDKN2A
11	female pregnancy	GO:007565	10.2	ADCYAP1, RLN1, PRL, PSG2, CRH, PTHLH
12	positive regulation of gene expression	GO:010628	10.1	NKX2-1, DNMT1, DNMT3B, CTGF, MAPK8, MET
13	positive regulation of JAK-STAT cascade	GO:046427	10.1	PRL, NOTCH1, GH1, IL6, IL29, KIT
14	release of cytochrome c from mitochondria	GO:001836	10.0	SMAD3, TP53, CASP3, CCK, BAX, BCL2L1
15	cellular response to amino acid stimulus	GO:071230	10.0	SOCS1, DNMT1, DNMT3A, DNMT3B, TNF, CDH1
16	angiogenesis	GO:001525	10.0	TEK, PTEN, CTGF, NRP2, ECM1, HMOX1
17	regulation of protein localization	GO:032880	9.9	ADCYAP1, SHH, MAPK8, INS, CDH2, BCL2
18	response to estradiol stimulus	GO:032355	9.9	SOCS1, ENO2, CCNE1, ESR1, GH1, PTGS2
19	cell-cell signaling	GO:007267	9.9	SSTR1, SSTR2, SSTR3, SHH, TAC1, POMC
20	phosphatidylinositol-mediated signaling	GO:048015	9.9	TSC2, TYMS, RPS6KB1, PTEN, ERBB2, IGF1
21	positive regulation of cell differentiation	GO:045597	9.9	NEUROD4, NEUROD1, CTGF, CCNE1, INS, CDX2
22	negative regulation of cell migration	GO:030336	9.8	NKX2-1, SHH, NF1, PTEN, DRD2, ENG
23	Ras protein signal transduction	GO:007265	9.8	NF1, TP53, IGF1, MAPK1, MAPK14, CDKN2A
24	heart development	GO:007507	9.7	NF1, SHH, TSC2, TH, ECE1, HDAC9
25	response to hypoxia	GO:001666	9.7	SMAD3, NF1, SHH, TH, ECE1, DRD2
26	endocrine pancreas development	GO:031018	9.7	NEUROD1, NKX2-2, PDX1, IAPP, IL6, INSM1
27	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.7	TP53, GH1, IGF1, CCK, ANGPT1, IL6
28	fibroblast growth factor receptor signaling pathway	GO:008543	9.6	ADCY2, TSC2, CTGF, PTEN, MAPK1, FGF9
29	positive regulation of protein phosphorylation	GO:001934	9.6	CTGF, TEK, TNF, ERBB2, CCND1, ENG
30	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.5	NFKB1, PDX1, SHH, DNMT3B, DNMT3A, DNMT1
31	positive regulation of cell migration	GO:030335	9.4	EGFR, NOTCH1, SMAD3, SNAI1, IGF1R, APC
32	cell proliferation	GO:008283	9.4	ERCC1, TP53, PTEN, PLK1, EGFR, PRL
33	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.4	TEK, TNF, ANGPT1, IL6, MET, CD44
34	cell surface receptor signaling pathway	GO:007166	9.4	ADCYAP1R1, PRL, GFRA1, EGFR, SSTR1, SST
35	wound healing	GO:042060	9.3	POU2F3, NF1, SMAD3, ERBB2, ENG, INS
36	positive regulation of apoptotic process	GO:043065	9.3	PTGS2, CTNNB1, NF1, NEUROD1, GAL, TNF
37	positive regulation of transcription, DNA-dependent	GO:045893	9.3	SNAI1, CTNNB1, SP1, TNF, SMAD3, NOTCH1
38	response to drug	GO:042493	9.2	PTGS2, SST, CTNNB1, RPS6KB1, DNMT3B, SOCS1
39	MAPK cascade	GO:000165	8.9	EGFR, NF1, TNF, MAPK1, MEN1, INS
40	axon guidance	GO:007411	8.9	ERBB2, NRP2, SHH, EGFR, GFRA1, NKX2-1
41	blood coagulation	GO:007596	8.8	MAPK1, IGF1, IFNA2, IFNB1, GNAS, TP53
42	negative regulation of cell proliferation	GO:008285	8.8	RAF1, CDKN1B, CDKN2A, MEN1, IL29, SSTR1
43	induction of apoptosis	GO:006917	8.8	SMAD3, DAXX, PTEN, TNF, TRAF3, CASP3
44	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.8	NFKB1, NOTCH1, SMAD3, CTNNB1, SP1, DRD2
45	nerve growth factor receptor signaling pathway	GO:048011	8.7	PTEN, NFKB1, TSC2, ADCY2, ADCYAP1, ADCYAP1R1
46	anti-apoptosis	GO:006916	8.4	IER3, GHRL, HMOX1, TNF, TEK, TERT
47	signal transduction	GO:007165	8.1	NTS, TEK, TRAF3, ERBB2, ESR1, ALCAM
48	apoptotic process	GO:006915	8.0	TJP1, TNF, TP53, TRAF3, CASP3, PTEN
49	positive regulation of cell proliferation	GO:008284	7.9	FGF9, NOTCH1, PDX1, SHH, EGFR, CSF3
50	negative regulation of apoptotic process	GO:043066	7.4	GCG, IL6, APC, ANGPT1, MAPK8, IGF1R

Molecular functions related to neuroendocrine tumor according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	neuropeptide hormone activity	GO:005184	10.9	GAL, ADCYAP1, NPY, CRH, NTS, CCK
2	somatostatin receptor activity	GO:004994	10.8	SSTR5, SSTR4, SSTR3, SSTR2, SSTR1
3	receptor binding	GO:005102	10.7	GFRA1, POMC, NPY, PGR, ADCYAP1, GDNF
4	beta-catenin binding	GO:008013	10.1	SMAD3, CTNNA1, ESR1, APC, MET, CDH1
5	transcription factor binding	GO:008134	10.0	NEUROD1, NKX2-2, DNMT1, SMAD3, CTNNB1, SP1
6	hormone activity	GO:005179	9.9	INS, CCK, IGF1, IAPP, CALCA, GH1
7	protein kinase binding	GO:019901	9.7	SOCS1, PLK1, SMAD3, PTEN, TP53, CCND1
8	protein phosphatase binding	GO:019903	9.6	EGFR, RPA2, CTNNB1, ERBB2, CDH1, CDKN1B
9	protein heterodimerization activity	GO:046982	9.0	ENO2, ERBB2, TP53, EGFR, NEUROD1, ADCY2
10	enzyme binding	GO:019899	8.9	NOTCH1, EGFR, CSF3, SLC18A2, PGR, ECM1
11	identical protein binding	GO:042802	8.6	ESR1, ERBB2, TP53, TNF, EGFR, SYP
12	protein homodimerization activity	GO:042803	8.5	TERT, PTGS2, DAXX, SP1, SMAD3, NFKB1
13	protein binding	GO:005515	4.1	TP53, CRH, PLK1, NOTCH1, RPS6KB1, RPA2