MCID: NRN004
MIFTS: 61

Neuroendocrine Tumor malady

Neuronal diseases, Cancer diseases categories

Summaries for Neuroendocrine Tumor

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63Wikipedia, 32MalaCards
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Wikipedia:63 Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous... more...

MalaCards: Neuroendocrine Tumor, also known as neuroendocrine tumors, is related to pancreatitis and neuroendocrine carcinoma. An important gene associated with Neuroendocrine Tumor is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Neuroscience. The compounds tyrosine and vegf have been mentioned in the context of this disorder. Affiliated tissues include lung, pancreas and liver, and related mouse phenotypes are nervous system and homeostasis/metabolism.

Aliases & Classifications for Neuroendocrine Tumor

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10DISEASES, 8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroendocrine tumor 8 10
neuroendocrine tumors 44 60
neuroendocrine carcinoma 10
carcinoma neuroendocrine 44
neuroendocrine neoplasm 8


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Disease Ontology8 DOID:169
ICD9CM27 209-209.99, 209
MeSH34 D018358
NCIt39 C3809

Related Diseases for Neuroendocrine Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Neuroendocrine Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 358)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.5SST
2neuroendocrine carcinoma31.0CHGA, GRP, SST, CDX2, ENO2, ASCL1
3thyroiditis30.7CALCA
4von hippel-lindau disease30.7MEN1
5duodenitis30.6GAST
6adenocarcinoma30.5SYP, NKX2-1, GHRL, MEN1, GAST, CCNB1
7paraganglioma30.5ENO2, SST, SSTR2, GRP, CALCA, GAST
8pheochromocytoma30.5ENO2, ASCL1, CDX2, SST, SSTR2, CALCA
9gastrinoma30.4CHGA, GRP, SSTR2, SST, ENO2, SYP
10cushing's syndrome30.4CALCA, MEN1, GHRL, SYP, CHGA, SST
11acromegaly30.4MEN1, GHRL, SSTR2, SST, GGH
12hypercalcemia30.4CHGA, MEN1, GAST, CALCA
13adenoma30.4CHGB, SSTR2, SST, MKI67, CDX2, GGH
14thyroid medullary carcinoma30.4GAST, MEN1, GHRL, NKX2-1, CHGA, CHGB
15thyroid cancer30.4CCNB1, CALCA, NKX2-1
16lung small cell carcinoma30.3CHGA, GRP, SSTR2, SST, INSM1, ENO2
17pituitary adenoma30.3MEN1, GHRL, SYP, CHGA, CHGB, SSTR2
18hypoglycemia30.3SST, CHGA, GHRL, GAST
19non-small cell lung carcinoma30.2NKX2-1, SYP, CHGA, GRP, ENO2
20insulinoma30.2CALCA, GAST, MEN1, GHRL, CHGA, GRP
21prostate cancer30.2CCNB1, CHGA, CHGB, GRP, MKI67, CDX2
22retinoblastoma30.2CCNB1, MEN1, SYP, MKI67, ENO2
23neurofibromatosis30.2ENO2, SST, MEN1
24pancreas disease30.2GAST
25islet cell tumor30.2SST, GAST
26melanoma30.1CCNB1, GHRL, NKX2-1, GRP, SSTR2, MKI67
27papillary carcinoma30.1CALCA, NKX2-1, SYP, CHGA, SSTR2, MKI67
28tubular adenocarcinoma30.1SYP, CHGA, CDX2, ENO2
29adenosquamous carcinoma30.1GRP, CHGA, NKX2-1
30hepatocellular carcinoma30.1CCNB1, MEN1, GHRL, NKX2-1, GRP, SSTR2
31lung cancer30.1NKX2-1, SYP, CHGA, GRP, CDX2, ENO2
32diarrhea30.1CPE, SST, CHGA, GAST, CALCA
33pancreatic cancer30.1CDX2, SST, SSTR2, GAST
34gastritis30.1GAST, GHRL, CDX2
35neuroblastoma30.1SYP, ENO2
36gastrointestinal stromal tumor30.1ENO2, MKI67
37acinar cell carcinoma30.1CHGA, GAST
38gastroduodenitis29.9GAST
39breast cancer29.9CCNB1, CALCA, MEN1, GRP, SSTR2, MKI67
40prolactinoma29.9SST, SSTR2, CHGB, CHGA, MEN1
41esophagitis29.9CDX2, GAST
42endometrial carcinoma29.9CCNB1, NKX2-1, MKI67
43barrett's esophagus29.9GAST, MKI67, CDX2
44cholangiocarcinoma29.9CDX2, CCNB1
45thymoma29.9NKX2-1
46parathyroid carcinoma29.9MEN1
47hypertension29.9CALCA
48bladder adenocarcinoma29.9CDX2
49olfactory neuroblastoma29.9SYP, ENO2
50squamous cell carcinoma29.9CCNB1, NKX2-1, SYP, CHGA, GRP, MKI67

Graphical network of the top 20 diseases related to Neuroendocrine Tumor:



Diseases related to neuroendocrine tumor

Clinical Features for Neuroendocrine Tumor

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Drugs & Therapeutics for Neuroendocrine Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Genetic Tests for Neuroendocrine Tumor

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Anatomical Context for Neuroendocrine Tumor

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32MalaCards
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MalaCards organs/tissues related to Neuroendocrine Tumor:

32
Lung, Pancreas, Liver, Prostate, Thyroid, Breast, Pituitary, Small intestine, Kidney, Cervix, Bone, Endothelial, Testes, Colon, Thymus, Spleen, Lymph node, Pancreatic islet, Brain, Appendix, Ovary, Adrenal gland, Heart, Testis, Spinal cord, Smooth muscle, Bone marrow, Pineal

Animal Models for Neuroendocrine Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuroendocrine Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000363111.3MEN1, NKX2-1, NKX2-2, SYP, CHGB, SSTR2
2MP:000537611.0CALCA, GAST, MEN1, GHRL, NKX2-2, CHGB
3MP:000537911.0CPE, GAST, MEN1, CHGB, CDX2, INSM1
4MP:000538110.8GAST, MEN1, GHRL, NKX2-1, SSTR2, SST

Publications for Neuroendocrine Tumor

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50PubMed
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Articles related to Neuroendocrine Tumor:

(show top 50)    (show all 985)
idTitleAuthorsYear
1
Recurrent acute pancreatitis in a patient with wirsungocele and neuroendocrine tumor of ampulla of Vater. (23306346)
2013
2
Surgery for a gastroenteropancreatic neuroendocrine tumor (GEPNET) in multiple endocrine neoplasia type 1. (23076685)
2013
3
Peritoneal metastasis of a neuroendocrine tumor of the gallbladder. (23826575)
2013
4
Expression of gremlin 1 correlates with increased angiogenesis and progression-free survival in patients with pancreatic neuroendocrine tumors. (22706573)
2013
5
Thymic neuroendocrine tumor presenting with the ectopic ACTH syndrome. (23676563)
2013
6
Immunohistochemical studies of pulmonary large cell neuroendocrine carcinoma: a possible association between staining patterns with neuroendocrine markers and tumor response to chemotherapy. (22498090)
2013
7
Gut neuroendocrine tumor blood qPCR fingerprint assay: characteristics and reproducibility. (24127543)
2013
8
Staging and treatment response evaluation in a metastatic neuroendocrine tumor of the pancreas with G2 grading: insights from multimodality diagnostic approach by F-18-FDG and Ga-68-DOTANOC PET/CT. (23247870)
2013
9
Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors. (22575867)
2012
10
Neuroendocrine tumor of the pancreas in a patient with tuberous sclerosis: a case report and review of the literature. (22169969)
2012
11
Neoadjuvant chemotherapy with capecitabine and temozolomide for unresectable pancreatic neuroendocrine tumor. (23275776)
2012
12
Risk factors for disease progression in advanced jejunoileal neuroendocrine tumors. (22205326)
2012
13
A giant neuroendocrine tumor of the thymus gland causing superior vena cava syndrome. (22644816)
2012
14
Long-term prognosis of an endoscopically treated rectal neuroendocrine tumor: 10-year experience in a single institution. (22647741)
2012
15
Preoperative finding of gastric neuroendocrine tumor (gastric carcinoid) in a patient evaluated for bariatric surgery. (21233025)
2011
16
Identification of Mac-2-binding protein as a putative marker of neuroendocrine tumors from the analysis of cell line secretomes. (20019050)
2010
17
Neuroendocrine tumor of the bladder. (21234264)
2010
18
The value of 11C-5-hydroxy-tryptophan positron emission tomography in neuroendocrine tumor diagnosis and management: experience from one center. (20332708)
2010
19
Interesting image. Pancreatic neuroendocrine tumor with involvement of the inferior mesenteric vein diagnosed by Ga-68 DOTA-TATE PET/CT. (20026975)
2010
20
Predicting neuroendocrine tumor (carcinoid) neoplasia using gene expression profiling and supervised machine learning. (19197975)
2009
21
Selective expression of CD44, a putative prostate cancer stem cell marker, in neuroendocrine tumor cells of human prostate cancer. (19189306)
2009
22
Biochemical testing for neuroendocrine tumors. (19855234)
2009
23
O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors. (19118063)
2009
24
Primary neuroendocrine carcinoma of the liver. From carcinoid tumor to small-cell hepatic carcinoma: case reports and review of the literature]. (18210116)
2008
25
Is surgery indicated for patients with symptomatic nonfunctioning pancreatic neuroendocrine tumor and unresectable hepatic metastases? (17960455)
2007
26
Chromogranin A: is it a useful marker of neuroendocrine tumors? (17513802)
2007
27
p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors. (17145768)
2007
28
Familial neuroendocrine tumor syndromes: from genetics to clinical practice. (17001463)
2006
29
Phase II study of temozolomide and thalidomide in patients with metastatic neuroendocrine tumors. (16421420)
2006
30
Laparoscopic distal pancreatectomy for neuroendocrine tumors of the pancreas. (15816491)
2005
31
Identification of tumor suppressor loci on the long arm of chromosome 5 in pulmonary large cell neuroendocrine carcinoma. (16236978)
2005
32
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia as a precursor to pulmonary neuroendocrine tumors. (15136447)
2004
33
Radical surgery for large-sized slow-growing neuroendocrine tumor of the pancreas. (17955585)
2002
34
Primary neuroendocrine tumor (carcinoid) of the mesocolon. (11344846)
2001
35
CCK receptors in human neuroendocrine tumors: clinical implications. (11713969)
2001
36
Molecular genetics of neuroendocrine tumors. (10940682)
2000
37
Endoscopic ultrasound is highly accurate and directs management in patients with neuroendocrine tumors of the pancreas. (11007228)
2000
38
Immunohistology of neuroendocrine and neuroectodermal tumors. (10968705)
2000
39
Neuroendocrine differentiation in Ewing's sarcomas and primitive neuroectodermal tumors revealed by reverse transcriptase-polymerase chain reaction of chromogranin mRNA. (9646033)
1998
40
The coexistence of 2 different neuroendocrine tumors of the upper gastrointestinal tract and pancreas]. (9861888)
1998
41
Metastatic neuroendocrine tumors to the thyroid gland mimicking medullary carcinoma: a pathologic and immunohistochemical study of six cases. (9236831)
1997
42
Somatostatin receptor scintigraphy and therapy of neuroendocrine (APUD) tumors of the head and neck. (8725546)
1996
43
Immunohistochemical study of pancreatic neuroendocrine tumor in Panthera tigris tigris. (8827685)
1996
44
Somatostatin receptor scintigraphy in neuroendocrine tumors exemplified by a patient with hepatic metastases of gastrinoma]. (7513113)
1994
45
A metastatic neuroendocrine anaplastic small cell tumor in a patient with multiple endocrine neoplasia type 1 syndrome. Assessment of disease status and response to doxorubicin, cyclophosphamide, etoposide chemotherapy through scintigraphic imaging with 111In-pentetreotide. (7922988)
1994
46
Tyrosine hydroxylase indicates cell differentiation of catecholamine biosynthesis in neuroendocrine tumors. (7523477)
1994
47
Somatostatin analogue therapy in functioning neuroendocrine gut tumors. (8359571)
1993
48
Scintigraphic localization of neuroendocrine tumors and their metastases using a somatostatin analog [111In-DTPA-d-phe1] octreotide]. (8101999)
1993
49
Galanin immunoreactivity in neuroendocrine tumors. (1718239)
1991
50
Nicotine, acetylcholine and bombesin are trophic growth factors in neuroendocrine cell lines derived from experimental hamster lung tumors. (1698239)
1990

Genetic Variations for Neuroendocrine Tumor

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Expression for genes affiliated with Neuroendocrine Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroendocrine Tumor

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Pathways for genes affiliated with Neuroendocrine Tumor

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53Reactome, 37NCBI BioSystems Database, 29KEGG, 4Cell Signaling Technology
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Compounds for genes affiliated with Neuroendocrine Tumor

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.9SSTR2, MKI67, CDX2, ENO2, ASCL1, GRP
2vegf4411.8MKI67, CALCA, SYP, MEN1, GRP, GHRL
3octreotide44 59 28 1114.7CALCA, GAST, CHGA, GRP, SSTR2, SST
4acth4411.6SST, CALCA, GAST, GHRL, SYP, CHGA
5paraffin4411.6CDX2, CCNB1, GHRL, MKI67, NKX2-1, ENO2
6thymidine44 2412.6GRP, CCNB1, MEN1, GHRL, SSTR2, MKI67
7calcium44 49 11 2414.6CCNB1, GAST, MEN1, SYP, CHGA, CHGB
8norepinephrine44 11 2413.6ENO2, CHGB, GRP, SST, SYP, GHRL
9adenylate4411.5CALCA, GAST, GRP, GHRL, SST, SSTR2
10testosterone44 59 11 2414.5GRP, SST, MKI67, CHGA, GAST, ENO2
11dopamine44 28 11 2414.5GAST, ENO2, CPE, SSTR2, GRP, GHRL
125-hydroxytryptamine4411.5ENO2, SST, CALCA, GHRL, SYP, CHGA
13gnrh4411.5NKX2-1, CHGA, GRP, SSTR2, SST, MKI67
14histamine44 28 2413.5SSTR2, CALCA, GAST, GRP, GHRL, SST
15acetylcholine44 49 28 11 2415.5SYP, CHGA, GRP, CALCA, ENO2, SST
16lactate4411.4CALCA, ENO2, GGH, MKI67, SST, GRP
17cisplatin44 49 59 1114.4CHGA, GAST, GRP, SYP, MKI67, ENO2
18serine4411.4CPE, CHGB, SYP, CCNB1, MEN1, GHRL
19retinoic acid44 2412.4ASCL1, NKX2-1, CCNB1, ENO2, MKI67, SST
20gaba4411.4GRP, CHGA, SST, GAST, GHRL, SYP
21epinephrine44 11 2413.4CALCA, MKI67, GRP, CHGA, GHRL, GAST
22progesterone44 59 28 11 2415.4NKX2-1, CHGA, MKI67, CDX2, ENO2, CCNB1
23111in-pentetreotide4411.3SSTR2, SST, CALCA, SYP, CHGA
24peptidylglycine4411.3CHGB, GRP, CPE, CHGA, GAST
25forskolin44 49 1113.3SSTR2, CALCA, ENO2, CPE, NKX2-1
26oxyntomodulin44 5912.3GHRL, SST, GRP, CHGA, GAST
27spec-t4411.2CALCA, SST, SSTR2, GRP, ENO2
28glucose4411.2GAST, GHRL, SSTR2, CPE, CCNB1
29dexamethasone44 49 28 1114.2ENO2, CHGB, GRP, NKX2-1, GHRL
30hematoxylin4411.2ENO2, NKX2-1, SYP, MKI67, CHGA
31c-peptide4411.2CPE, SST, CHGA, GHRL, GAST
32propranolol44 28 49 11 2415.2GRP, CALCA, GAST, CHGA, SST
33mibg4411.1CALCA, ENO2, CHGA, SST
34atropine44 28 1113.1GRP, GAST, CALCA, GHRL
35glutamate4411.1GHRL, CPE, GAST
36pirenzepine44 28 1113.1GAST, GRP, GHRL, SST
37dtpa4411.1GRP, SSTR2, GAST, SST
385-hydroxyindoleacetic acid44 2412.1ENO2, SST, CHGA, GAST
39creatinine4411.0GRP, GAST, GHRL, SYP, CHGA
40hydrocortisone44 2 59 1114.0SST, GAST, CALCA, GRP, GHRL
41guanine44 11 2413.0SSTR2, CALCA, GRP
42lafutidine4410.9GAST, SST, CALCA
43vitamin d4410.9CALCA, CHGA, GHRL, CDX2, GAST, MEN1
44smcc4410.9SYP, CHGA, ENO2
45nifedipine44 49 28 1113.9GAST, GHRL, GRP, SST, CHGA
46minigastrin4410.9SST, GRP, GAST
47loxiglumide4410.8GAST, SST, GRP
48bromodeoxyuridine4410.7GAST, CCNB1, ENO2, MKI67, CHGA
49pepsinogen4410.7GRP, GAST, CHGA
50carbachol44 28 1112.5GAST, GHRL, CHGA, GRP, SST

GO Terms for genes affiliated with Neuroendocrine Tumor

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16Gene Ontology
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Cellular components related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.1CPE, SST, GRP, CHGB, CHGA, GHRL

Biological processes related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex GABAergic interneuron differentiationGO:02189210.7ASCL1, NKX2-1
2spinal cord oligodendrocyte cell fate specificationGO:02153010.6ASCL1, NKX2-2
3neuron fate specificationGO:04866510.6ASCL1, NKX2-2
4type B pancreatic cell developmentGO:00332310.5NKX2-2, INSM1
5neuropeptide signaling pathwayGO:00721810.4CPE, GRP, CALCA

Molecular functions related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.8SST, CHGB, GAST, CALCA

Products for genes affiliated with Neuroendocrine Tumor

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Sources for Neuroendocrine Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet