MCID: NRN004
MIFTS: 51

Neuroendocrine Tumor malady

Summaries for Neuroendocrine Tumor

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous... more...

MalaCards: Neuroendocrine Tumor, also known as neuroendocrine tumors, is related to neuroendocrine carcinoma and multiple endocrine neoplasia. An important gene associated with Neuroendocrine Tumor is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Neuroscience. The compounds tyrosine and vegf have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and homeostasis/metabolism.

Aliases & Classifications for Neuroendocrine Tumor

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt
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Aliases & Descriptions:

neuroendocrine tumor 8 10
neuroendocrine tumors 45 61
neuroendocrine neoplasm 8


External Ids:

Disease Ontology8 DOID:169
ICD9CM27 209-209.99, 209
MeSH35 D018358
NCIt40 C3809

Related Diseases for Neuroendocrine Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neuroendocrine Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 229)
idRelated DiseaseScoreTop Affiliating Genes
1neuroendocrine carcinoma31.1CALCA, GAST, MEN1, NKX2-1, ASCL1, ENO2
2multiple endocrine neoplasia30.9CHGB, CHGA, GAST, MEN1, CALCA
3adenocarcinoma30.6CHGA, CHGB, GRP, SSTR2, GHRL, SST
4paraganglioma30.5CHGB, CHGA, SYP, MEN1, GAST, CALCA
5pheochromocytoma30.5CHGA, ASCL1, ENO2, CALCA, SYP, CDX2
6cushing's syndrome30.5SST, CHGA, CALCA, SYP, GHRL, MEN1
7gastrinoma30.5ENO2, SST, SSTR2, GRP, CHGA, SYP
8acromegaly30.5GGH, MEN1, GHRL, SSTR2, SST
9hypercalcemia30.5CALCA, CHGA, MEN1, GAST
10carcinoid syndrome30.4ASCL1, ENO2, GGH, CDX2, MKI67, SST
11adenoma30.4ENO2, ASCL1, GGH, CDX2, MKI67, CCNB1
12thyroid medullary carcinoma30.4ASCL1, ENO2, SST, SSTR2, GRP, CHGB
13thyroid cancer30.4NKX2-1, CALCA, CCNB1
14hypoglycemia30.4SST, GHRL, GAST, CHGA
15neurofibromatosis30.4ENO2, MEN1, SST
16insulinoma30.3CPE, INSM1, SST, SSTR2, GRP, CHGA
17pituitary tumors30.3INSM1, SST, MEN1, GHRL, CHGA, CHGB
18pancreatic islet cell tumors30.1SYP, CALCA, GAST, MEN1, CHGA, SST
19gastrointestinal stromal tumor30.1MKI67, ENO2
20acinar cell carcinoma30.1GAST, CHGA
21squamous cell carcinoma29.9MKI67, ENO2, GRP, SYP, NKX2-1, CCNB1
22colorectal cancer29.9GAST, MEN1, NKX2-1, MKI67, CDX2, GRP
23atrophic gastritis29.9GHRL, SST, CDX2, GAST, CHGA, MEN1
24somatostatinoma29.9SST, SSTR2, CHGA, GAST, CALCA
25merkel cell carcinoma29.9SYP, CHGA, SST, ENO2, NKX2-1
26large cell carcinoma29.9CHGA, ENO2, GRP, SYP, NKX2-1
27vipoma29.9SST, CHGA, MEN1, GAST
28ependymoma29.9SYP, MKI67, MEN1, ENO2
29hyperinsulinemic hypoglycemia29.9SST, CHGA, GAST
30phaeochromocytoma29.9CHGA, CALCA
31teratoma29.9ENO2, NKX2-1
32adrenocortical carcinoma29.9CHGA, MKI67, SYP
33gastric ulcer29.9GAST, GHRL
34von hippel-lindau disease29.9MEN1
35pernicious anemia29.9GAST
36arthritis29.9CALCA, GHRL
37duodenal ulcer29.9GRP, GAST
38amyotrophic lateral sclerosis29.9SYP
39pancreatic ductal carcinoma29.9CHGA, GRP
40neuroepithelioma29.9SYP, ENO2
41anal neuroendocrine tumor10.9
42somatostatin analog10.7
43n syndrome10.7
44pancreatic endocrine tumors10.5
45intestinal neuroendocrine tumor10.4
46small cell carcinoma10.3
47gastro-enteropancreatic neuroendocrine tumor10.3
48acute pancreatitis10.2
49esophageal neuroendocrine tumor10.2
50gastrointestinal neuroendocrine tumor cancer10.2

Graphical network of the top 20 diseases related to Neuroendocrine Tumor:



Diseases related to neuroendocrine tumor

Clinical Features for Neuroendocrine Tumor

Drugs & Therapeutics for Neuroendocrine Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Neuroendocrine Tumor

Drug clinical trials:

Search ClinicalTrials for Neuroendocrine Tumor

Search NIH Clinical Center for Neuroendocrine Tumor

Search CenterWatch for Neuroendocrine Tumor

Genetic Tests for Neuroendocrine Tumor

Anatomical Context for Neuroendocrine Tumor

Animal Models for Neuroendocrine Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Neuroendocrine Tumor

Sources:
51PubMed
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Articles related to Neuroendocrine Tumor:

(show top 50)    (show all 993)
idTitleAuthorsYear
1
Capsaicin induces cytotoxicity in pancreatic neuroendocrine tumor cells via mitochondrial action. (24075930)
2014
2
Humoral hypercalcemia of malignancy caused by parathyroid hormone-related peptide-secreting neuroendocrine tumors. Report of six cases. (23719609)
2013
3
Bone metastasis from a neuroendocrine tumor detected by 99m-technetium-hydrazinonicotinyl-Tyr3-octreotide single-photon emission computed tomography/computed tomography. (24250034)
2013
4
An unusual presentation of neuroendocrine tumor of the small bowel. (22678987)
2013
5
Neuroendocrine tumor of the cystic duct. (23082709)
2012
6
The importance of clinical information in patients with gastroenteropancreatic neuroendocrine tumor. (22584507)
2012
7
Unusual, metastatic, or neuroendocrine tumor of the pancreas: a diagnosis with endoscopic ultrasound-guided fine-needle aspiration and immunohistochemistry. (22421714)
2012
8
Spindle cell typical carcinoid tumor (well-differentiated neuroendocrine carcinoma) diagnosed by electromagnetic navigation bronchoscopy with cytologic rapid on-site evaluation. (21987437)
2012
9
11C-5-hydroxytryptophan positron emission tomography after radiofrequency ablation of neuroendocrine tumor liver metastases. (22381780)
2012
10
A reoperation of a local recurrent nonfunctioning pancreatic neuroendocrine tumor after pancreaticoduodenectomy. (23089418)
2012
11
Human neuroendocrine tumor cell lines as a three-dimensional model for the study of human neuroendocrine tumor therapy. (22929519)
2012
12
Long-term disease control with sunitinib in a patient with metastatic pancreatic neuroendocrine tumor (NET) associated with Von Hippel-Lindau syndrome (VHL). (22415670)
2012
13
Concomitant Nonfunctional Pancreatic Neuroendocrine Tumor and Gastric GIST in a Patient Without Neurofibromatosis Type 1. (22083533)
2011
14
Histologic features of low- and intermediate-grade neuroendocrine carcinoma (typical and atypical carcinoid tumors) of the lung. (20462655)
2011
15
Coincidence of mature cystic teratoma and serotonin-producing neuroendocrine tumor of the ileum. (22105478)
2011
16
A case of primary uterine cervical neuroendocrine tumor with meningeal carcinomatosis confirmed by diagnostic imaging and autopsy. (21161314)
2011
17
Cocaine- and amphetamine-regulated transcript in neuroendocrine tumors. (21832817)
2011
18
Neuroendocrine tumor in choledochal cyst--case report and review of literature. (22246096)
2011
19
IL-2 -330 T/G SNP and serum values-potential new tumor markers in neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NETs). (20049409)
2010
20
The North American Neuroendocrine Tumor Society (NANETS) guidelines: mission, goals, and process. (20664469)
2010
21
Dual role of RASSF1 as a tumor suppressor and an oncogene in neuroendocrine tumors of the lung. (21036752)
2010
22
RegIV expression showing specificity to gastrointestinal tract and its potential role in diagnosing digestive tract neuroendocrine tumor. (20349522)
2010
23
Invasive neuroendocrine tumor of the kidney: a case report. (21139916)
2009
24
Primary neuroendocrine tumor of the sacrum: case report and review of the literature. (19360403)
2009
25
Differential cytotoxicity of novel somatostatin and dopamine chimeric compounds on bronchopulmonary and small intestinal neuroendocrine tumor cell lines. (18618499)
2008
26
Frequency and number of neuroendocrine tumor cells in prostate cancer: no difference between radical prostatectomy specimens from patients with and without neoadjuvant hormonal therapy. (17342745)
2007
27
Differential expression of alternatively spliced mRNA forms of the insulin-like growth factor 1 receptor in human neuroendocrine tumors. (16596194)
2006
28
Neuroendocrine tumors express PAC1 receptors. (16888199)
2006
29
Poorly differentiated neuroendocrine tumor of the larynx: challenging and highly aggressive. (17168143)
2006
30
Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor. (16253894)
2005
31
Interpretation of the post-surgical Somatostatin Receptor Scintigram of a Primary Neuroendocrine Tumor of the Thymus: a case report and literature review. (15788105)
2005
32
A novel approach in the treatment of neuroendocrine gastrointestinal tumors: additive antiproliferative effects of interferon-gamma and meta-iodobenzylguanidine. (15154969)
2004
33
hASH1 expression is closely correlated with endocrine phenotype and differentiation extent in pulmonary neuroendocrine tumors. (14657947)
2004
34
Nonsteroidal anti-inflammatory drugs inhibit growth of human neuroendocrine tumor cells via G1 cell-cycle arrest. (14566837)
2003
35
Demonstration of high monoaminoxidase-A levels in neuroendocrine gastroenteropancreatic tumors in vitro and in vivo-tumor visualization using positron emission tomography with 11C-harmine. (12900293)
2003
36
Preoperative localization of a neuroendocrine tumor of the pancreas with EUS-guided fine needle tattooing. (11923783)
2002
37
Pigmented neuroendocrine tumor of the lung, showing neuromelanin. (12685551)
2002
38
Cystic fibrosis transmembrane conductance regulator modulates neurosecretory function in pulmonary neuroendocrine cell-related tumor cell line models. (12397014)
2002
39
Comparative study of serotonin and bombesin in adenocarcinomas and neuroendocrine tumors of the colon. (11783909)
2001
40
Neuroendocrine tumor markers. (11587555)
2001
41
Malignant Sertoli cell tumor of the ovary metastatic to the lung mimicking neuroendocrine carcinoma: report of a case. (10459047)
1999
42
Yttrium 90 DOTATOC: a new somatostatin analog for cancer therapy of neuroendocrine tumors]. (10479965)
1999
43
Mechanism of retinoblastoma gene inactivation in the spectrum of neuroendocrine lung tumors. (9476905)
1998
44
CD44 isoform expression in the diffuse neuroendocrine system. II. Benign and malignant tumors. (8985743)
1996
45
Immunohistochemical study of 17 cases of rectal neuroendocrine tumors]. (8767675)
1996
46
Clinical efficacy of octreotide in the treatment of metastatic neuroendocrine tumors. A study by the Italian Trials in Medical Oncology Group. (8625251)
1996
47
Primary cutaneous neuroendocrine tumors. Diagnostic use of cytogenetic and MIC2 analysis. (7627931)
1995
48
Immunohistochemistry of synapsin I and synaptophysin in human nervous system and neuroendocrine tumors. Applications in diagnostic neuro-oncology. (8287627)
1993
49
The role of interleukin-1 and tumor necrosis factor alpha in the neurochemical and neuroendocrine responses to endotoxin. (1473014)
1992
50
Recent advances in carcinoids and gastrointestinal neuroendocrine tumors. (2043691)
1991

Genetic Variations for Neuroendocrine Tumor

Expression for genes affiliated with Neuroendocrine Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroendocrine Tumor

Search GEO for disease gene expression data for Neuroendocrine Tumor.

Pathways for genes affiliated with Neuroendocrine Tumor

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG, 4Cell Signaling Technology
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Compounds for genes affiliated with Neuroendocrine Tumor

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
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Compounds related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.9SSTR2, MKI67, CDX2, ENO2, ASCL1, GRP
2vegf4511.8MKI67, CALCA, SYP, MEN1, GRP, GHRL
3octreotide45 60 29 1114.7CALCA, GAST, CHGA, GRP, SSTR2, SST
4acth4511.6SST, CALCA, GAST, GHRL, SYP, CHGA
5paraffin4511.6CDX2, CCNB1, GHRL, MKI67, NKX2-1, ENO2
6thymidine45 2412.6GRP, CCNB1, MEN1, GHRL, SSTR2, MKI67
7calcium45 50 11 2414.6CCNB1, GAST, MEN1, SYP, CHGA, CHGB
8norepinephrine45 11 2413.6ENO2, CHGB, GRP, SST, SYP, GHRL
9adenylate4511.5CALCA, GAST, GRP, GHRL, SST, SSTR2
10testosterone45 60 11 2414.5GRP, SST, MKI67, CHGA, GAST, ENO2
11dopamine45 29 11 2414.5GAST, ENO2, CPE, SSTR2, GRP, GHRL
125-hydroxytryptamine4511.5ENO2, SST, CALCA, GHRL, SYP, CHGA
13gnrh4511.5NKX2-1, CHGA, GRP, SSTR2, SST, MKI67
14histamine45 29 2413.5SSTR2, CALCA, GAST, GRP, GHRL, SST
15acetylcholine45 50 29 11 2415.5SYP, CHGA, GRP, CALCA, ENO2, SST
16lactate4511.4CALCA, ENO2, GGH, MKI67, SST, GRP
17cisplatin45 50 60 1114.4CHGA, GAST, GRP, SYP, MKI67, ENO2
18serine4511.4CPE, CHGB, SYP, CCNB1, MEN1, GHRL
19retinoic acid45 2412.4ASCL1, NKX2-1, CCNB1, ENO2, MKI67, SST
20gaba4511.4GRP, CHGA, SST, GAST, GHRL, SYP
21epinephrine45 11 2413.4CALCA, MKI67, GRP, CHGA, GHRL, GAST
22progesterone45 60 29 11 2415.4NKX2-1, CHGA, MKI67, CDX2, ENO2, CCNB1
23111in-pentetreotide4511.3SSTR2, SST, CALCA, SYP, CHGA
24peptidylglycine4511.3CHGB, GRP, CPE, CHGA, GAST
25forskolin45 50 1113.3SSTR2, CALCA, ENO2, CPE, NKX2-1
26oxyntomodulin45 6012.3GHRL, SST, GRP, CHGA, GAST
27spec-t4511.2CALCA, SST, SSTR2, GRP, ENO2
28glucose4511.2GAST, GHRL, SSTR2, CPE, CCNB1
29dexamethasone45 50 29 1114.2ENO2, CHGB, GRP, NKX2-1, GHRL
30hematoxylin4511.2ENO2, NKX2-1, SYP, MKI67, CHGA
31c-peptide4511.2CPE, SST, CHGA, GHRL, GAST
32propranolol45 29 50 11 2415.2GRP, CALCA, GAST, CHGA, SST
33mibg4511.1CALCA, ENO2, CHGA, SST
34atropine45 29 1113.1GRP, GAST, CALCA, GHRL
35glutamate4511.1GHRL, CPE, GAST
36pirenzepine45 29 1113.1GAST, GRP, GHRL, SST
37dtpa4511.1GRP, SSTR2, GAST, SST
385-hydroxyindoleacetic acid45 2412.1ENO2, SST, CHGA, GAST
39creatinine4511.0GRP, GAST, GHRL, SYP, CHGA
40hydrocortisone45 2 60 1114.0SST, GAST, CALCA, GRP, GHRL
41guanine45 11 2413.0SSTR2, CALCA, GRP
42lafutidine4510.9GAST, SST, CALCA
43vitamin d4510.9CALCA, CHGA, GHRL, CDX2, GAST, MEN1
44smcc4510.9SYP, CHGA, ENO2
45nifedipine45 50 29 1113.9GAST, GHRL, GRP, SST, CHGA
46minigastrin4510.9SST, GRP, GAST
47loxiglumide4510.8GAST, SST, GRP
48bromodeoxyuridine4510.7GAST, CCNB1, ENO2, MKI67, CHGA
49pepsinogen4510.7GRP, GAST, CHGA
50carbachol45 29 1112.5GAST, GHRL, CHGA, GRP, SST

GO Terms for genes affiliated with Neuroendocrine Tumor

Sources:
16Gene Ontology
See all sources

Cellular components related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.1CPE, SST, GRP, CHGB, CHGA, GHRL

Biological processes related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cerebral cortex GABAergic interneuron differentiationGO:02189210.7ASCL1, NKX2-1
2spinal cord oligodendrocyte cell fate specificationGO:02153010.6ASCL1, NKX2-2
3neuron fate specificationGO:04866510.6ASCL1, NKX2-2
4type B pancreatic cell developmentGO:00332310.5NKX2-2, INSM1
5neuropeptide signaling pathwayGO:00721810.4CPE, GRP, CALCA

Molecular functions related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00517910.8SST, CHGB, GAST, CALCA

Products for genes affiliated with Neuroendocrine Tumor

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Sources for Neuroendocrine Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet