MCID: NRN004
MIFTS: 60

Neuroendocrine Tumor malady

Cancer diseases, Neuronal diseases categories
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Summaries for Neuroendocrine Tumor

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Wikipedia:65 Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous... more...

MalaCards based summary: Neuroendocrine Tumor, also known as neuroendocrine neoplasm, is related to multiple endocrine neoplasia and cushing's syndrome. An important gene associated with Neuroendocrine Tumor is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Adenylate cyclase activating neuropeptides and SIDS Susceptibility Pathways. The compounds lithium chloride and ghrp-6 have been mentioned in the context of this disorder. Affiliated tissues include lung, pancreas and liver, and related mouse phenotypes are digestive/alimentary and normal.

Disease Ontology:8 An endocrine gland cancer that has material basis in neuroendocrine cells.

Aliases & Classifications for Neuroendocrine Tumor

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 57SNOMED-CT, 34MeSH, 27ICD9CM
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Neuroendocrine Tumor, Aliases & Descriptions:

Name: Neuroendocrine Tumor 8 10
Neuroendocrine Neoplasm 8 62
Neuroendocrine Tumors 44 62
 
Carcinoma, Neuroendocrine 62
Carcinoma Neuroendocrine 44
Neuroendocrine Carcinoma 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:169
NCIt39 C3809
MeSH34 D018358
ICD9CM27 209, 209-209.99

Related Diseases for Neuroendocrine Tumor

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Diseases related to Neuroendocrine Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 261)
idRelated DiseaseScoreTop Affiliating Genes
1multiple endocrine neoplasia31.4CHGA, CALCA
2cushing's syndrome31.3SST
3gastrinoma31.2CHGA, SST
4paraganglioma31.0CHGA, SST, CALCA
5tubular adenocarcinoma30.8CHGA, CDX2
6acromegaly30.8SST, GHRL, GGH
7hypoglycemia30.7GHRL, SST, CHGA
8vipoma30.7SST, CHGA
9hyperinsulinemic hypoglycemia30.6CHGA, SST
10bladder adenocarcinoma30.6CDX2
11large cell carcinoma30.5CHGA, NKX2-1
12pheochromocytoma30.5CHGA, ASCL1, SST, CALCA, CDX2
13phaeochromocytoma30.5CHGA, CALCA
14pituitary adenoma30.5MKI67, CHGA, SST, GHRL
15adenosquamous carcinoma30.4CHGA, NKX2-1
16gastritis30.4GHRL, CDX2
17somatostatinoma30.4CALCA, SST, CHGA
18pancreatic cancer30.3CDX2, SST, CHGA
19diarrhea30.3CPE, CHGA, SST, CALCA
20insulinoma30.2CPE, CHGA, SST, GHRL, CALCA
21merkel cell carcinoma30.1CHGA, SST, NKX2-1
22lung small cell carcinoma30.0CHGA, ASCL1, SST, CALCA, NKX2-1
23barrett's esophagus30.0MKI67, CDX2
24non-small cell lung carcinoma30.0CDX2, NKX2-1, CHGA, MKI67
25atrophic gastritis29.9CDX2, GHRL, SST, CHGA
26neuroendocrine carcinoma29.9CHGA, ASCL1, SST, CALCA, NKX2-1, CDX2
27lung cancer29.7CDX2, NKX2-1, ASCL1, CHGA
28adenocarcinoma29.6MKI67, CHGA, ASCL1, SST, GHRL, NKX2-1
29breast cancer29.6MKI67, CHGA, GHRL, NKX2-1, CDX2
30melanoma29.6MKI67, TPH1, GHRL, NKX2-1, CDX2
31thyroid medullary carcinoma29.3CHGA, ASCL1, SST, GHRL, CALCA, NKX2-1
32adenoma29.1MKI67, CHGA, ASCL1, SST, GHRL, CALCA
33carcinoid syndrome28.7MKI67, TPH1, CDX2, GGH, NKX2-1, CALCA
34pancreatitis11.1
35small cell neuroendocrine carcinoma11.0
36somatostatin analog10.7
37hepatitis10.7
38pulmonary neuroendocrine tumor10.7
39thymic neuroendocrine carcinoma10.6
40neuroendocrine carcinoma of the cervix10.6
41gastrointestinal neuroendocrine tumor10.6
42von hippel-lindau disease10.6
43thyroiditis10.6
44intestinal disease10.6SST
45prostatitis10.5
46duodenitis10.5
47ovarian large-cell neuroendocrine carcinoma10.4
48endocrine gland cancer10.4SST, CHGA
49zollinger-ellison syndrome10.4CHGA, SST
50wermer syndrome10.4CHGA, SST

Graphical network of the top 20 diseases related to Neuroendocrine Tumor:



Diseases related to neuroendocrine tumor

Symptoms for Neuroendocrine Tumor

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Drugs & Therapeutics for Neuroendocrine Tumor

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Drug clinical trials:

Search ClinicalTrials for Neuroendocrine Tumor

Search NIH Clinical Center for Neuroendocrine Tumor

Genetic Tests for Neuroendocrine Tumor

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Anatomical Context for Neuroendocrine Tumor

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MalaCards organs/tissues related to Neuroendocrine Tumor:

32
Lung, Pancreas, Liver, Thyroid, Breast, Prostate, Pituitary, Small intestine, Bone, Kidney, Spleen, Thymus, Testes, Endothelial, Spinal cord, Colon, Cervix, Pancreatic islet, Bone marrow, Lymph node, Brain, Heart, Appendix, Pineal, Smooth muscle, Adrenal gland, Ovary

Animal Models for Neuroendocrine Tumor or affiliated genes

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MGI Mouse Phenotypes related to Neuroendocrine Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5CDX2, NKX2-1, GHRL, SST, CPE
2MP:00028738.3ASCL1, SST, GHRL, CALCA, NKX2-2, CDX2
3MP:00053798.1CDX2, CPE, CHGA, ASCL1, GHRL, NKX2-2
4MP:00053787.9TPH1, CPE, CHGA, ASCL1, SST, NKX2-2
5MP:00053867.9TPH1, CPE, ASCL1, SST, GHRL, CALCA
6MP:00053767.5TPH1, CPE, CHGA, SST, GHRL, CALCA

Publications for Neuroendocrine Tumor

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Articles related to Neuroendocrine Tumor:

(show top 50)    (show all 865)
idTitleAuthorsYear
1
Primary large-cell neuroendocrine tumor of the breast. (23458218)
2013
2
Inhibin-expressing clear cell neuroendocrine tumor of the ampulla: an unusual presentation of von Hippel-Lindau disease. (23913169)
2013
3
Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model. (24139798)
2013
4
The dedifferentiation of neuroendocrine tumor metastases: myth or reality? (23529331)
2013
5
Endoscopic submucosal dissection of a duodenal neuroendocrine tumor. (24368076)
2013
6
MK-2206 causes growth suppression and reduces neuroendocrine tumor marker production in medullary thyroid cancer through Akt inhibition. (23900743)
2013
7
INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors. (23438439)
2013
8
99mTc-tektrotyd SPECT/MRI in the diagnosis of a gastroenteropancreatic neuroendocrine tumor. (22391730)
2012
9
Retrospective analysis of seventy-one patients with neuroendocrine tumor and review of the literature. (21618056)
2012
10
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. (22588069)
2012
11
Neuroendocrine tumor of the uterine cervix: a clinicopathologic study of 14 cases. (22695823)
2012
12
Neuroendocrine tumor of the cystic duct. (23082709)
2012
13
Somatostatin and dopamine receptor profile of gastroenteropancreatic neuroendocrine tumors: an immunohistochemical study. (21287294)
2011
14
Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case. (21390554)
2011
15
Comparison of (68)Ga-DOTA-Tyr(3)-octreotide and (18)F-fluoro-L-dihydroxyphenylalanine positron emission tomography in neuroendocrine tumor patients. (20168288)
2010
16
Mammalian target of rapamycin signaling activation patterns in neuroendocrine tumors of the lung. (20817788)
2010
17
ZM447439, a novel promising aurora kinase inhibitor, provokes antiproliferative and proapoptotic effects alone and in combination with bio- and chemotherapeutic agents in gastroenteropancreatic neuroendocrine tumor cell lines. (19923785)
2010
18
Chromogranin A as a biochemical marker for the management of neuroendocrine tumors: a multicenter study developed in Argentina. (19845257)
2009
19
Hepatic ablation for neuroendocrine tumor metastases. (20017158)
2009
20
Thyroid metastases from typical carcinoid of the lung differentiating between medullary thyroid carcinoma and neuroendocrine tumor metastasis to the thyroid. (19415998)
2009
21
Cytomorphology of a metastatic basaloid squamous carcinoma from an intranasal tumor: a diagnostic mimic for a neuroendocrine tumor--a rare case report. (19373914)
2009
22
LKB1 protein expression in neuroendocrine tumors of the lung. (18199157)
2008
23
The effect of transforming growth factor beta on human neuroendocrine tumor BON cell proliferation and differentiation is mediated through somatostatin signaling. (18567806)
2008
24
Gastrointestinal neuroendocrine tumors: a role for targeted therapies? (17639038)
2007
25
Neuroendocrine tumors. Molecular targeted therapy for carcinoid and islet-cell carcinoma. (17382271)
2007
26
Non-functioning well-differentiated neuroendocrine tumor of the extrahepatic bile duct: an unusual suspect? (17897922)
2007
27
The novel mTOR inhibitor RAD001 (everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells. (17310129)
2007
28
Familial neuroendocrine tumor syndromes: from genetics to clinical practice. (17001463)
2006
29
RET and neuroendocrine tumors. (17036197)
2006
30
TNF-alpha promoter single nucleotide polymorphisms in gastroenteropancreatic neuroendocrine tumors. (17164537)
2006
31
Peptide receptors in neuroendocrine tumors of the lung as potential tools for radionuclide diagnosis and therapy. (17043625)
2006
32
Identification of DLK1 variants in pituitary- and neuroendocrine tumors. (16403460)
2006
33
The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors? (16428931)
2006
34
Neuroendocrine tumor of small bowel. (15332039)
2004
35
Accuracy and clinical correlates of two different methods for chromogranin A assay in neuroendocrine tumors. (15646836)
2004
36
RET and neuroendocrine tumors. (15013219)
2004
37
Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. (12843152)
2003
38
Nonsteroidal anti-inflammatory drugs inhibit growth of human neuroendocrine tumor cells via G1 cell-cycle arrest. (14566837)
2003
39
Liver transplantation for metastatic neuroendocrine tumor disease. (12644147)
2003
40
Preoperative localization of a neuroendocrine tumor of the pancreas with EUS-guided fine needle tattooing. (11923783)
2002
41
The pigmented "black" neuroendocrine tumor of the pancreas: a question of origin. (11745274)
2001
42
Tumor markers in neuroendocrine tumors. (10940685)
2000
43
Correlative immunohistochemical and reverse transcriptase polymerase chain reaction analysis of somatostatin receptor type 2 in neuroendocrine tumors of the lung. (10718213)
2000
44
Molecular genetics of neuroendocrine tumors. (10940682)
2000
45
Somatostatin receptor scintigraphy in neuroendocrine tumors exemplified by a patient with hepatic metastases of gastrinoma]. (7513113)
1994
46
A benign neuroendocrine tumor of the lung: study on the origin of the so-called sclerosing hemangioma of the lung]. (8082241)
1994
47
A calcitonin-producing neuroendocrine tumor of the larynx: a case report. (8236510)
1993
48
Immunogold detection of chromogranin A in the neuroendocrine tumor. (8427030)
1993
49
Somatostatin receptor imaging in the diagnosis and treatment of neuroendocrine tumors. (1356013)
1992
50
Detection of functional interferon alpha receptors in human neuroendocrine tumor cell lines using a new monoclonal antibody. (1316782)
1992

Variations for Neuroendocrine Tumor

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Expression for genes affiliated with Neuroendocrine Tumor

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Expression patterns in normal tissues for genes affiliated with Neuroendocrine Tumor

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Pathways for genes affiliated with Neuroendocrine Tumor

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Pathways related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CALCA, CPE
29.4NKX2-2, SST, ASCL1, TPH1
39.3MKI67, TPH1, NKX2-2, NKX2-1
4
Show member pathways
9.2CDX2, GHRL, CPE

Compounds for genes affiliated with Neuroendocrine Tumor

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Compounds related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1lithium chloride4410.3CHGA, ASCL1
2ghrp-628 4411.2GHRL, SST
3lafutidine4410.2SST, CALCA
45-hydroxytryptophan4410.2TPH1, CHGA, SST
55-hydroxyindoleacetic acid44 2411.2TPH1, CHGA, SST
6111in-pentetreotide4410.1CHGA, SST, CALCA
7mibg4410.1CALCA, SST, CHGA
8clonidine44 50 28 1113.0CHGA, SST, CALCA
9oxyntomodulin44 6111.0GHRL, SST, CHGA
10levodopa44 1111.0TPH1, CHGA, SST
11propranolol44 28 50 24 1114.0CALCA, SST, CHGA
12ghrp4410.0GHRL, SST
13cinacalcet44 28 1111.9CALCA, GHRL
14amphetamine44 50 1111.9TPH1, SST, GHRL
15naloxone44 28 50 1112.9SST, GHRL, GGH
16hematoxylin449.9MKI67, CHGA, NKX2-1
17p002449.9CHGA, TPH1, MKI67
18atropine44 28 1111.8CALCA, GHRL, SST
19pramlintide44 1110.8GHRL, CALCA
20gaba449.7GHRL, SST, CHGA, TPH1
21acth449.7CHGA, SST, GHRL, CALCA
22peptidylglycine449.6CHGA, CPE
23amide449.6GHRL, CHGA, CPE
24histamine44 28 2411.5CALCA, GHRL, SST, CHGA
25c-peptide449.5GHRL, SST, CHGA, CPE
26hydrocortisone44 2 61 1112.5CALCA, GHRL, SST
27epinephrine44 24 1111.5MKI67, CHGA, SST, GHRL, CALCA
285-hydroxytryptamine449.5TPH1, CHGA, SST, GHRL, CALCA
29vitamin d449.4CHGA, GHRL, CALCA, CDX2
30norepinephrine44 24 1111.4TPH1, CHGA, SST, GHRL, CALCA
31acetylcholine44 50 28 24 1113.4TPH1, CHGA, SST, GHRL, CALCA
32testosterone44 61 24 1112.4CALCA, GHRL, SST, CHGA, MKI67
33gnrh449.4MKI67, CHGA, SST, GHRL, NKX2-1
34vegf449.3MKI67, CHGA, SST, GHRL, CALCA
35progesterone44 28 61 24 1113.3MKI67, TPH1, CHGA, NKX2-1, CDX2
36octreotide44 61 28 1112.2GGH, CALCA, GHRL, SST, CHGA, MKI67
37paraffin449.2MKI67, CHGA, GHRL, NKX2-1, CDX2
38nitric oxide44 24 1111.2MKI67, TPH1, CHGA, GHRL, CALCA
39lactate449.2MKI67, CHGA, SST, GHRL, CALCA, GGH
40cyclic amp44 2410.2NKX2-1, CALCA, GHRL, CHGA, TPH1
41arginine449.0MKI67, TPH1, CPE, CHGA, SST, GHRL
42fatty acid448.9MKI67, CHGA, GHRL, CDX2
43glucose448.9MKI67, CPE, CHGA, SST, GHRL, GGH
44zinc44 249.8MKI67, CPE, CHGA, GHRL, NKX2-1
45forskolin44 50 1110.7NKX2-1, CALCA, GHRL, CHGA, CPE, TPH1
46dopamine44 28 24 1111.6TPH1, CPE, CHGA, ASCL1, SST, GHRL
47glutamate448.6TPH1, CPE, CHGA, SST, GHRL, CALCA
48lysine448.6ASCL1, CPE, HIST1H1B, MKI67
49estrogen448.6MKI67, TPH1, CHGA, GHRL, CALCA, NKX2-1
50tyrosine448.6MKI67, TPH1, CHGA, ASCL1, GHRL, NKX2-1

GO Terms for genes affiliated with Neuroendocrine Tumor

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Cellular components related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.6CALCA, SST, ASCL1
2transport vesicle membraneGO:0306589.4CHGA, CPE

Biological processes related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1spinal cord oligodendrocyte cell fate specificationGO:02153010.1NKX2-2, ASCL1
2neuron fate specificationGO:04866510.0NKX2-2, ASCL1
3response to heatGO:0094089.9CALCA, SST
4cerebral cortex GABAergic interneuron differentiationGO:0218929.9NKX2-1, ASCL1
5negative regulation of ossificationGO:0302799.9TPH1, CALCA
6oligodendrocyte developmentGO:0140039.8NKX2-2, ASCL1
7response to hormoneGO:0097259.3NKX2-1, GHRL

Products for genes affiliated with Neuroendocrine Tumor

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Sources for Neuroendocrine Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet