MCID: NRN004
MIFTS: 58

Neuroendocrine Tumor malady

Neuronal diseases, Cancer diseases categories
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Summaries for Neuroendocrine Tumor

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65Wikipedia, 33MalaCards
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Wikipedia:65 Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous... more...

MalaCards: Neuroendocrine Tumor, also known as neuroendocrine tumors, is related to multiple endocrine neoplasia and cushing's syndrome. An important gene associated with Neuroendocrine Tumor is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Adenylate cyclase activating neuropeptides and SIDS Susceptibility Pathways. The compounds lithium chloride and ghrp-6 have been mentioned in the context of this disorder. Affiliated tissues include lung, pancreas and liver, and related mouse phenotypes are digestive/alimentary and normal.

Aliases & Classifications for Neuroendocrine Tumor

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10DISEASES, 8Disease Ontology, 45Novoseek, 62UMLS, 40NCIt, 27ICD9CM, 58SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroendocrine tumor 8 10
neuroendocrine tumors 45 62
neuroendocrine carcinoma 10
carcinoma neuroendocrine 45
neuroendocrine neoplasm 8


External Ids:

Disease Ontology8 DOID:169
NCIt40 C3809
ICD9CM27 209, 209-209.99
MeSH35 D018358

Related Diseases for Neuroendocrine Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Neuroendocrine Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1multiple endocrine neoplasia31.1CHGA, CALCA
2cushing's syndrome30.7SST
3gastrinoma30.7CHGA, SST
4paraganglioma30.7CHGA, SST, CALCA
5acromegaly30.6SST, GHRL, GGH
6pheochromocytoma30.6CHGA, ASCL1, SST, CALCA, CDX2
7hypoglycemia30.5GHRL, SST, CHGA
8large cell carcinoma30.4CHGA, NKX2-1
9thyroid cancer30.4CHGA, SST, CALCA, NKX2-1
10pituitary adenoma30.3MKI67, CHGA, SST, GHRL
11neuroendocrine carcinoma30.3CHGA, ASCL1, SST, CALCA, NKX2-1, CDX2
12adenocarcinoma30.3MKI67, CHGA, ASCL1, SST, GHRL, NKX2-1
13tubular adenocarcinoma30.3CHGA, CDX2
14insulinoma30.2CPE, CHGA, SST, GHRL, CALCA
15gastritis30.2GHRL, CDX2
16diarrhea30.2CPE, CHGA, SST, CALCA
17non-small cell lung carcinoma30.1CDX2, NKX2-1, CHGA, MKI67
18adenoma30.1MKI67, CHGA, ASCL1, SST, GHRL, CALCA
19lung small cell carcinoma30.1CHGA, ASCL1, SST, CALCA, NKX2-1
20vipoma30.1SST, CHGA
21hyperinsulinemic hypoglycemia30.1CHGA, SST
22phaeochromocytoma30.1CHGA, CALCA
23somatostatinoma30.0CALCA, SST, CHGA
24melanoma30.0MKI67, TPH1, GHRL, NKX2-1, CDX2
25pancreatic cancer30.0CDX2, SST, CHGA
26adenosquamous carcinoma30.0CHGA, NKX2-1
27merkel cell carcinoma30.0CHGA, SST, NKX2-1
28hepatocellular carcinoma30.0CDX2, NKX2-1, GHRL, MKI67
29barrett's esophagus30.0MKI67, CDX2
30atrophic gastritis29.9CDX2, GHRL, SST, CHGA
31lung cancer29.9CDX2, NKX2-1, ASCL1, CHGA
32breast cancer29.8MKI67, CHGA, GHRL, NKX2-1, CDX2
33thyroid medullary carcinoma29.8CHGA, ASCL1, SST, GHRL, CALCA, NKX2-1
34carcinoid syndrome29.8MKI67, TPH1, CDX2, GGH, NKX2-1, CALCA
35pancreatitis11.0
36small cell neuroendocrine carcinoma10.9
37somatostatin analog10.7
38hepatitis10.7
39pulmonary neuroendocrine tumor10.7
40cutaneous neuroendocrine carcinoma10.6
41neuroendocrine carcinoma of the cervix10.6
42thymic neuroendocrine carcinoma10.6
43gastrointestinal neuroendocrine tumor10.6
44thyroiditis10.6
45intestinal neuroendocrine tumor10.5
46von hippel-lindau disease10.5
47prostatitis10.5
48duodenitis10.4
49ovarian large-cell neuroendocrine carcinoma10.4
50hypercalcemia10.4

Graphical network of the top 20 diseases related to Neuroendocrine Tumor:



Diseases related to neuroendocrine tumor

Symptoms for Neuroendocrine Tumor

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Drugs & Therapeutics for Neuroendocrine Tumor

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Neuroendocrine Tumor

Search NIH Clinical Center for Neuroendocrine Tumor

Genetic Tests for Neuroendocrine Tumor

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Anatomical Context for Neuroendocrine Tumor

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33MalaCards
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MalaCards organs/tissues related to Neuroendocrine Tumor:

33
Lung, Pancreas, Liver, Thyroid, Breast, Prostate, Pituitary, Kidney, Small intestine, Bone, Testes, Spleen, Thymus, Cervix, Endothelial, Appendix, Colon, Lymph node, Pancreatic islet, Heart, Adrenal gland, Brain, Ovary, Spinal cord, Smooth muscle, Pineal, Bone marrow

Animal Models for Neuroendocrine Tumor or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Neuroendocrine Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.5CDX2, NKX2-1, GHRL, SST, CPE
2MP:00028738.3ASCL1, SST, GHRL, CALCA, NKX2-2, CDX2
3MP:00053798.1CDX2, CPE, CHGA, ASCL1, GHRL, NKX2-2
4MP:00053787.9TPH1, CPE, CHGA, ASCL1, SST, NKX2-2
5MP:00053867.9TPH1, CPE, ASCL1, SST, GHRL, CALCA
6MP:00053767.5TPH1, CPE, CHGA, SST, GHRL, CALCA

Publications for Neuroendocrine Tumor

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52PubMed
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Articles related to Neuroendocrine Tumor:

(show top 50)    (show all 830)
idTitleAuthorsYear
1
Primary large-cell neuroendocrine tumor of the breast. (23458218)
2013
2
Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model. (24139798)
2013
3
The dedifferentiation of neuroendocrine tumor metastases: myth or reality? (23529331)
2013
4
Endoscopic submucosal dissection of a duodenal neuroendocrine tumor. (24368076)
2013
5
MK-2206 causes growth suppression and reduces neuroendocrine tumor marker production in medullary thyroid cancer through Akt inhibition. (23900743)
2013
6
INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors. (23438439)
2013
7
Sunitinib malate as first-line treatment for an advanced, poorly differentiated pancreatic neuroendocrine tumor. (23718311)
2013
8
99mTc-tektrotyd SPECT/MRI in the diagnosis of a gastroenteropancreatic neuroendocrine tumor. (22391730)
2012
9
Retrospective analysis of seventy-one patients with neuroendocrine tumor and review of the literature. (21618056)
2012
10
Duodenal gastrinoma with multiple gastric neuroendocrine tumors secondary to chronic Helicobacter pylori gastritis. (22588069)
2012
11
Neuroendocrine tumor of the uterine cervix: a clinicopathologic study of 14 cases. (22695823)
2012
12
Neuroendocrine tumor of the cystic duct. (23082709)
2012
13
Somatostatin and dopamine receptor profile of gastroenteropancreatic neuroendocrine tumors: an immunohistochemical study. (21287294)
2011
14
Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case. (21390554)
2011
15
Comparison of (68)Ga-DOTA-Tyr(3)-octreotide and (18)F-fluoro-L-dihydroxyphenylalanine positron emission tomography in neuroendocrine tumor patients. (20168288)
2010
16
Mammalian target of rapamycin signaling activation patterns in neuroendocrine tumors of the lung. (20817788)
2010
17
ZM447439, a novel promising aurora kinase inhibitor, provokes antiproliferative and proapoptotic effects alone and in combination with bio- and chemotherapeutic agents in gastroenteropancreatic neuroendocrine tumor cell lines. (19923785)
2010
18
Chromogranin A as a biochemical marker for the management of neuroendocrine tumors: a multicenter study developed in Argentina. (19845257)
2009
19
Hepatic ablation for neuroendocrine tumor metastases. (20017158)
2009
20
Thyroid metastases from typical carcinoid of the lung differentiating between medullary thyroid carcinoma and neuroendocrine tumor metastasis to the thyroid. (19415998)
2009
21
Cytomorphology of a metastatic basaloid squamous carcinoma from an intranasal tumor: a diagnostic mimic for a neuroendocrine tumor--a rare case report. (19373914)
2009
22
LKB1 protein expression in neuroendocrine tumors of the lung. (18199157)
2008
23
The effect of transforming growth factor beta on human neuroendocrine tumor BON cell proliferation and differentiation is mediated through somatostatin signaling. (18567806)
2008
24
Gastrointestinal neuroendocrine tumors: a role for targeted therapies? (17639038)
2007
25
Neuroendocrine tumors. Molecular targeted therapy for carcinoid and islet-cell carcinoma. (17382271)
2007
26
Non-functioning well-differentiated neuroendocrine tumor of the extrahepatic bile duct: an unusual suspect? (17897922)
2007
27
The novel mTOR inhibitor RAD001 (everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells. (17310129)
2007
28
Familial neuroendocrine tumor syndromes: from genetics to clinical practice. (17001463)
2006
29
RET and neuroendocrine tumors. (17036197)
2006
30
TNF-alpha promoter single nucleotide polymorphisms in gastroenteropancreatic neuroendocrine tumors. (17164537)
2006
31
Peptide receptors in neuroendocrine tumors of the lung as potential tools for radionuclide diagnosis and therapy. (17043625)
2006
32
Identification of DLK1 variants in pituitary- and neuroendocrine tumors. (16403460)
2006
33
The Raf-1 pathway: a molecular target for treatment of select neuroendocrine tumors? (16428931)
2006
34
Neuroendocrine tumor of small bowel. (15332039)
2004
35
Accuracy and clinical correlates of two different methods for chromogranin A assay in neuroendocrine tumors. (15646836)
2004
36
RET and neuroendocrine tumors. (15013219)
2004
37
Circulating ghrelin levels in patients with pancreatic and gastrointestinal neuroendocrine tumors: identification of one pancreatic ghrelinoma. (12843152)
2003
38
Nonsteroidal anti-inflammatory drugs inhibit growth of human neuroendocrine tumor cells via G1 cell-cycle arrest. (14566837)
2003
39
Liver transplantation for metastatic neuroendocrine tumor disease. (12644147)
2003
40
Preoperative localization of a neuroendocrine tumor of the pancreas with EUS-guided fine needle tattooing. (11923783)
2002
41
The pigmented "black" neuroendocrine tumor of the pancreas: a question of origin. (11745274)
2001
42
Tumor markers in neuroendocrine tumors. (10940685)
2000
43
Correlative immunohistochemical and reverse transcriptase polymerase chain reaction analysis of somatostatin receptor type 2 in neuroendocrine tumors of the lung. (10718213)
2000
44
Molecular genetics of neuroendocrine tumors. (10940682)
2000
45
Somatostatin receptor scintigraphy in neuroendocrine tumors exemplified by a patient with hepatic metastases of gastrinoma]. (7513113)
1994
46
A benign neuroendocrine tumor of the lung: study on the origin of the so-called sclerosing hemangioma of the lung]. (8082241)
1994
47
A calcitonin-producing neuroendocrine tumor of the larynx: a case report. (8236510)
1993
48
Immunogold detection of chromogranin A in the neuroendocrine tumor. (8427030)
1993
49
Somatostatin receptor imaging in the diagnosis and treatment of neuroendocrine tumors. (1356013)
1992
50
Detection of functional interferon alpha receptors in human neuroendocrine tumor cell lines using a new monoclonal antibody. (1316782)
1992

Variations for Neuroendocrine Tumor

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Expression for genes affiliated with Neuroendocrine Tumor

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroendocrine Tumor

Search GEO for disease gene expression data for Neuroendocrine Tumor.

Pathways for genes affiliated with Neuroendocrine Tumor

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50PathCards, 12EMD Millipore, 38NCBI BioSystems Database, 5Cell Signaling Technology, 55Reactome
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Pathways related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6CALCA, CPE
29.4NKX2-2, SST, ASCL1, TPH1
39.3MKI67, TPH1, NKX2-2, NKX2-1
4
Show member pathways
9.2CDX2, GHRL, CPE

Compounds for genes affiliated with Neuroendocrine Tumor

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45Novoseek, 29IUPHAR, 24HMDB, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 3BitterDB
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Compounds related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 82)
idCompoundScoreTop Affiliating Genes
1lithium chloride4510.3CHGA, ASCL1
2ghrp-629 4511.2GHRL, SST
3lafutidine4510.2SST, CALCA
45-hydroxytryptophan4510.2TPH1, CHGA, SST
55-hydroxyindoleacetic acid45 2411.2TPH1, CHGA, SST
6111in-pentetreotide4510.1CHGA, SST, CALCA
7mibg4510.1CALCA, SST, CHGA
8clonidine45 51 29 1113.0CHGA, SST, CALCA
9oxyntomodulin45 6111.0GHRL, SST, CHGA
10levodopa45 1111.0TPH1, CHGA, SST
11propranolol45 29 51 24 1114.0CALCA, SST, CHGA
12ghrp4510.0GHRL, SST
13cinacalcet45 29 1111.9CALCA, GHRL
14amphetamine45 51 1111.9TPH1, SST, GHRL
15naloxone45 29 51 1112.9SST, GHRL, GGH
16hematoxylin459.9MKI67, CHGA, NKX2-1
17p002459.9CHGA, TPH1, MKI67
18atropine45 29 1111.8CALCA, GHRL, SST
19pramlintide45 1110.8GHRL, CALCA
20gaba459.7GHRL, SST, CHGA, TPH1
21acth459.7CHGA, SST, GHRL, CALCA
22peptidylglycine459.6CHGA, CPE
23amide459.6GHRL, CHGA, CPE
24histamine45 29 2411.5CALCA, GHRL, SST, CHGA
25c-peptide459.5GHRL, SST, CHGA, CPE
26hydrocortisone45 3 61 1112.5CALCA, GHRL, SST
27epinephrine45 24 1111.5MKI67, CHGA, SST, GHRL, CALCA
285-hydroxytryptamine459.5TPH1, CHGA, SST, GHRL, CALCA
29vitamin d459.4CHGA, GHRL, CALCA, CDX2
30norepinephrine45 24 1111.4TPH1, CHGA, SST, GHRL, CALCA
31acetylcholine45 51 29 24 1113.4TPH1, CHGA, SST, GHRL, CALCA
32testosterone45 61 24 1112.4CALCA, GHRL, SST, CHGA, MKI67
33gnrh459.4MKI67, CHGA, SST, GHRL, NKX2-1
34vegf459.3MKI67, CHGA, SST, GHRL, CALCA
35progesterone45 29 61 24 1113.3MKI67, TPH1, CHGA, NKX2-1, CDX2
36octreotide45 61 29 1112.2GGH, CALCA, GHRL, SST, CHGA, MKI67
37paraffin459.2MKI67, CHGA, GHRL, NKX2-1, CDX2
38nitric oxide45 24 1111.2MKI67, TPH1, CHGA, GHRL, CALCA
39lactate459.2MKI67, CHGA, SST, GHRL, CALCA, GGH
40cyclic amp45 2410.2NKX2-1, CALCA, GHRL, CHGA, TPH1
41arginine459.0MKI67, TPH1, CPE, CHGA, SST, GHRL
42fatty acid458.9MKI67, CHGA, GHRL, CDX2
43glucose458.9MKI67, CPE, CHGA, SST, GHRL, GGH
44zinc45 249.8MKI67, CPE, CHGA, GHRL, NKX2-1
45forskolin45 51 1110.7NKX2-1, CALCA, GHRL, CHGA, CPE, TPH1
46dopamine45 29 24 1111.6TPH1, CPE, CHGA, ASCL1, SST, GHRL
47glutamate458.6TPH1, CPE, CHGA, SST, GHRL, CALCA
48lysine458.6ASCL1, CPE, HIST1H1B, MKI67
49estrogen458.6MKI67, TPH1, CHGA, GHRL, CALCA, NKX2-1
50tyrosine458.6MKI67, TPH1, CHGA, ASCL1, GHRL, NKX2-1

GO Terms for genes affiliated with Neuroendocrine Tumor

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16Gene Ontology
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Cellular components related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430259.6CALCA, SST, ASCL1
2transport vesicle membraneGO:0306589.4CHGA, CPE

Biological processes related to Neuroendocrine Tumor according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1spinal cord oligodendrocyte cell fate specificationGO:02153010.1NKX2-2, ASCL1
2neuron fate specificationGO:04866510.0NKX2-2, ASCL1
3response to heatGO:0094089.9CALCA, SST
4cerebral cortex GABAergic interneuron differentiationGO:0218929.9NKX2-1, ASCL1
5negative regulation of ossificationGO:0302799.9TPH1, CALCA
6oligodendrocyte developmentGO:0140039.8NKX2-2, ASCL1
7response to hormoneGO:0097259.3NKX2-1, GHRL

Products for genes affiliated with Neuroendocrine Tumor

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Sources for Neuroendocrine Tumor

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet