MCID: NRP002
MIFTS: 46

Neuroepithelioma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Neuroepithelioma

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Neuroblastoma (NB) is the most common extracranial solid cancer in childhood and the most common cancer... more...

MalaCards: Neuroepithelioma, also known as neuroectodermal tumors, is related to peripheral primitive neuroectodermal tumor and neuroblastoma. An important gene associated with Neuroepithelioma is EWSR1 (EWS RNA-binding protein 1), and among its related pathways are Transcription CREB pathway and Monoamine GPCRs. The compounds noradrenaline and phenylpropanolamine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, brain and bone, and related mouse phenotypes are endocrine/exocrine gland and normal.

Description from OMIM:48 612219

Aliases & Classifications for Neuroepithelioma

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44NIH Rare Diseases, 48OMIM, 46Novoseek, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroepithelioma 44 48 46
neuroectodermal tumors 63


Related Diseases for Neuroepithelioma

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18GeneCards, 19GeneDecks
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Diseases related to Neuroepithelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral primitive neuroectodermal tumor30.6MYCN, EWSR1
2neuroblastoma10.5
3sarcoma10.5
4primitive neuroectodermal tumor10.5
5soft tissue peripheral neuroepithelioma10.2
6bone peripheral neuroepithelioma10.2
7neuronitis10.1
8cerebral primitive neuroectodermal tumor10.1EWSR1
9embryonal rhabdomyosarcoma10.1EWSR1, MYCN
10thyroid medullary carcinoma10.0MYCN, CCK
11psychotic disorder10.0DRD1, CCK
12ganglioneuroblastoma10.0NPY, MYCN
13bulimia nervosa10.0NPY, CCK
14autonomic neuropathy10.0NPY, CCK
15ganglioneuroma10.0NPY, MYCN
16eating disorder10.0NPY, CCK
17anxiety disorder10.0CCK, NPY
18respiratory failure10.0NPY, CCK
19prader-willi syndrome10.0NPY, CCK
20alcohol dependence10.0DRD1, NPY
21anorexia nervosa10.0NPY, CCK
22congestive heart failure10.0NPY, ADRB1
23mood disorder10.0DRD1, NPY
24essential hypertension10.0NPY, DRD1, ADRB1
25huntington's disease10.0DRD1, NPY
26neuroendocrine tumor10.0MYCN, CCK, NPY
27hepatitis c10.0
28olfactory neuroblastoma10.0
29microphthalmia10.0
30coloboma10.0
31hepatitis10.0
32meningioma10.0
33retinoblastoma10.0
34rhabdomyosarcoma10.0
35transitional cell carcinoma10.0
36cerebellar degeneration10.0
37paraneoplastic cerebellar degeneration10.0
38hepatitis c virus10.0
39teratoma10.0
40glaucoma10.0NPY, ADRB1
41embryonal cancer10.0LIF, MYCN
42schizophrenia10.0CCK, DRD1, NPY
43congenital heart disease9.9LIF, ADRB1, NPY
44pheochromocytoma9.9MYCN, LIF, NPY
45obesity9.9LIF, ADRB1, CCK, NPY
46malignant glioma9.9MYCN, LIF, ADRB1, NPY
47alzheimer's disease9.9LIF, CCK, DRD1, NPY

Graphical network of the top 20 diseases related to Neuroepithelioma:



Diseases related to neuroepithelioma

Symptoms for Neuroepithelioma

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48OMIM
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Clinical features from OMIM:

612219

Drugs & Therapeutics for Neuroepithelioma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neuroepithelioma

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Anatomical Context for Neuroepithelioma

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34MalaCards
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MalaCards organs/tissues related to Neuroepithelioma:

34
Adrenal gland, Brain, Bone, Pineal, Cervix, Colon, Uterus, Kidney, Spinal cord, Cerebellum

Animal Models for Neuroepithelioma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Neuroepithelioma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2EWSR1, LIF, ADRB1, CCK
2MP:00028738.2EWSR1, MYCN, DRD1, NPY
3MP:00053818.1NPY, DRD1, LIF, MYCN
4MP:00053698.1EWSR1, MYCN, LIF, ADRB1, DRD1
5MP:00053758.0NPY, DRD1, ADRB1, LIF, EWSR1
6MP:00107687.9DRD1, ADRB1, LIF, MYCN, EWSR1
7MP:00053907.9EWSR1, MYCN, LIF, ADRB1, NPY
8MP:00036317.5MYCN, LIF, CCK, DRD1, NPY
9MP:00053787.4EWSR1, MYCN, LIF, ADRB1, DRD1, NPY
10MP:00053767.2MYCN, LIF, ADRB1, CCK, DRD1, NPY

Publications for Neuroepithelioma

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53PubMed
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Articles related to Neuroepithelioma:

(show top 50)    (show all 124)
idTitleAuthorsYear
1
Solitary epidural brain metastasis of a peripheral neuroepithelioma (a primitive neuroectodermal tumor): a case report. (22470583)
2008
2
Polyphenotypic peripheral neuroepithelioma occuring in the foot: a case report. (17474251)
2007
3
Paraneoplastic cerebellar degeneration in olfactory neuroepithelioma. (16361612)
2006
4
Olfactory neuroepithelioma: an immunohistochemical and ultrastructural study. (17080716)
2006
5
Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. (12873973)
2003
6
Antisense to glucosylceramide synthase in human neuroepithelioma affects cell growth but not apoptosis. (12032678)
2002
7
Peripheral neuroepithelioma with ganglion cells: report of two cases and review of the literature. (9841705)
1999
8
An autopsy case of peripheral neuroepithelioma in posterior mediastinum with p53 point mutation. (9617873)
1998
9
Collision tumor: a peripheral neuroepithelioma and a transitional-cell carcinoma occurring simultaneously in the renal pelvis. (9869830)
1997
10
Retinoic acid-induced regulation of neuropeptide Y receptor expression and function in the neuroepithelioma line SK-N-MC. (9165460)
1997
11
Paracrine mediation of calcium signaling in human SK-N-MCIXC neuroepithelioma cells. (8760029)
1996
12
Intra- and intercellular calcium signaling in human neuroepithelioma cells. (8906559)
1996
13
Immunohistochemical profile of monoclonal antibody O13: antibody that recognizes glycoprotein p30/32MIC2 and is useful in diagnosing Ewing's sarcoma and peripheral neuroepithelioma. (7513503)
1994
14
Second messenger activators regulate CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC. (7514375)
1994
15
Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma. (8439553)
1993
16
Regulation of CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC in response to second messenger activators. (7694875)
1993
17
Peripheral neuroepithelioma of the soft tissues. A retrospective analysis of fifteen pediatric patients. (8328643)
1993
18
Use of HBA 71 and anti-beta 2-microglobulin to distinguish peripheral neuroepithelioma from neuroblastoma. (8375858)
1993
19
Fine needle aspiration of peripheral neuroepithelioma of soft tissues. (1542998)
1992
20
Unicolor and bicolor in situ hybridization in the diagnosis of peripheral neuroepithelioma and related tumors. (1384659)
1992
21
Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoints. (1283315)
1992
22
Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines. (1741160)
1992
23
Cyclic AMP potentiates receptor-stimulated phosphoinositide hydrolysis in human neuroepithelioma cells. (1355263)
1992
24
Peripheral neuroepithelioma: a light microscopic, immunocytochemical, and ultrastructural study. (1371873)
1992
25
Case report 682. Neuroepithelioma of soft tissues of the knee. (1896883)
1991
26
Adult peripheral neuroepithelioma in Meckel's cave. (1997905)
1991
27
Identification of multiple phosphoinositide-linked receptors on human SK-N-MC neuroepithelioma cells. (1681032)
1991
28
Characterization and regulation of beta 1-adrenergic receptors in a human neuroepithelioma cell line. (1671088)
1991
29
The cholecystokinin gene is abundantly co-expressed with gastrin-releasing peptide, enkephalin and neuropeptide Y genes in a clonal human neuroepithelioma cell line. (2384178)
1990
30
Nerve growth factor-induced differentiation of human neuroblastoma and neuroepithelioma cell lines. (1964795)
1990
31
Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line. (2205380)
1990
32
A case of malignant neuroepithelioma in the retroperitoneum]. (2407879)
1990
33
Neuropeptide Y binding and inhibition of cAMP accumulation in human neuroepithelioma cells. (2159234)
1990
34
Peripheral neuroectodermal sarcoma of soft tissue (peripheral neuroepithelioma): a pathologic study of ten cases with differential diagnosis regarding other small, round-cell sarcomas. (2656493)
1989
35
Spontaneous olfactory neuroepithelioma in a domestic medaka (Oryzias latipes). (2720659)
1989
36
Expression of the cholecystokinin gene by cultured human primitive neuroepithelioma cell lines. (2753982)
1989
37
Primary peripheral neuroepithelioma of the orbit with intracranial extension. (3191459)
1988
38
Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepithelioma. (3390826)
1988
39
Treatment of peripheral neuroepithelioma in children and young adults. (3316513)
1987
40
Neuroepithelioma (neuroblastoma) arising in an adult. A case report. (4044631)
1985
41
Extraskeletal Ewing's sarcoma (peripheral neuroepithelioma). (4089998)
1985
42
Peripheral neuroepithelioma in childhood. (6498781)
1984
43
Chromosome translocation in peripheral neuroepithelioma. (6749231)
1984
44
Olfactory neuroepithelioma in a cynomolgus monkey (Macaca fascicularis). (1123841)
1975
45
Malignant neuroepithelioma in childhood. A report of three cases. (5372849)
1969
46
Tumors in amphibians. I. Histology of a neuroepithelioma in Siredon mexicanum. (4163837)
1967
47
Olfactory neuroepithelioma. Report of a case (13853935)
1959
48
Neuroepithelioma; its place in the histogenetic classification of primary neuroectodermal brain tumors. (13097186)
1953
49
Intraorbital melanosis and intracranial neuroepithelioma of the optic nerve. (20990384)
1946
50
Neuroepithelioma of the Cerebellum. (19969839)
1929

Variations for Neuroepithelioma

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Expression for genes affiliated with Neuroepithelioma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroepithelioma

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Pathways for genes affiliated with Neuroepithelioma

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51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 52PharmGKB, 13EMD Millipore, 5Cell Signaling Technology, 31KEGG
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Compounds for genes affiliated with Neuroepithelioma

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30IUPHAR, 46Novoseek, 25HMDB, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 3BitterDB
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Compounds related to Neuroepithelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1noradrenaline3010.0DRD1, ADRB1
2phenylpropanolamine46 25 1212.0ADRB1, DRD1
3raclopride46 3010.9CCK, DRD1
4asenapine30 1210.9ADRB1, DRD1
5[met]enkephalin469.8NPY, CCK
6cyclo(his-pro)469.7CCK, NPY
7octadecaneuropeptide469.7CCK, NPY
8sulpiride46 30 1211.7NPY, DRD1
9bethanechol46 30 1211.7CCK, NPY
10enterostatin469.7CCK, NPY
11npff469.7CCK, NPY
12alpha msh469.7CCK, NPY
13incretin469.7NPY, CCK
14prazosin46 30 52 1212.6NPY, ADRB1
15muscimol46 62 3011.6NPY, DRD1
16fenfluramine46 30 1211.6CCK, NPY
17nicardipine46 30 1211.6CCK, DRD1
18oxyntomodulin46 6210.6NPY, CCK
19orlistat46 62 1211.6NPY, CCK
20phosphoramidon46 1210.4CCK, NPY
21methamphetamine46 52 1211.4NPY, DRD1
22amphetamine46 52 1211.3NPY, DRD1, CCK
23atropine46 30 1211.3NPY, DRD1, CCK
24opiate469.3CCK, DRD1, NPY
25cocaine46 1210.3NPY, DRD1, CCK
26naloxone46 30 52 1212.2DRD1, CCK
27gaba469.2NPY, DRD1, CCK
28nmda46 3010.1NPY, DRD1, ADRB1
29phenylephrine46 30 25 1212.0LIF, ADRB1, NPY
30isoproterenol46 1210.0NPY, ADRB1, LIF
31catecholamine468.9MYCN, ADRB1, DRD1, NPY
32glutamine468.9NPY, CCK, EWSR1
33adenylate468.9NPY, DRD1, CCK, ADRB1
34acth468.8LIF, CCK, NPY
35glutamate468.8ADRB1, CCK, DRD1, NPY
36genistein46 30 62 3 25 1213.7MYCN, LIF, DRD1
37paraffin468.5EWSR1, MYCN, LIF, NPY
38carbachol46 30 1210.5NPY, DRD1, CCK, LIF
39acetylcholine46 52 30 25 1212.5LIF, CCK, DRD1, NPY
40glucose468.3LIF, ADRB1, CCK, NPY
41serine468.3EWSR1, MYCN, LIF, ADRB1, DRD1
42cyclic amp46 259.2EWSR1, LIF, ADRB1, DRD1, NPY
43arginine468.2NPY, CCK, ADRB1, LIF, EWSR1
44norepinephrine46 25 1210.1LIF, ADRB1, CCK, DRD1, NPY
45forskolin46 52 1210.1LIF, ADRB1, CCK, DRD1, NPY
46nitric oxide46 25 1210.1MYCN, LIF, ADRB1, DRD1, NPY
47calcium46 52 25 1210.7EWSR1, LIF, ADRB1, CCK, DRD1, NPY
48retinoic acid46 258.6EWSR1, MYCN, LIF, ADRB1, CCK, NPY
49dopamine46 30 25 1210.6NPY, DRD1, CCK, ADRB1, LIF, MYCN
50tyrosine467.2EWSR1, MYCN, LIF, ADRB1, CCK, DRD1

GO Terms for genes affiliated with Neuroepithelioma

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17Gene Ontology
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Biological processes related to Neuroepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation of adenylate cyclase activityGO:0071909.7DRD1, ADRB1
2behavioral fear responseGO:0016629.6DRD1, CCK
3positive regulation of cAMP biosynthetic processGO:0308199.6DRD1, ADRB1
4memoryGO:0076139.3DRD1, ADRB1
5G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.3DRD1, NPY
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1CCK, LIF

Molecular functions related to Neuroepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.3NPY, CCK
2dopamine bindingGO:0352409.3DRD1, ADRB1

Products for genes affiliated with Neuroepithelioma

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Sources for Neuroepithelioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
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60SNOMED-CT via Orphanet
63UMLS
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