MCID: NRP002
MIFTS: 41

Neuroepithelioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Neuroepithelioma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Neuroblastoma (NB) is the most common extracranial solid cancer in childhood and the most common cancer... more...

MalaCards: Neuroepithelioma, also known as neuroectodermal tumors, is related to medulloblastoma and cerebral primitive neuroectodermal tumor. An important gene associated with Neuroepithelioma is EWSR1 (EWS RNA-binding protein 1), and among its related pathways are Selected targets of CREB1 and Notch Pathway. The compounds cycloheximide and askin have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, and related mouse phenotypes are adipose tissue and embryogenesis.

Description from OMIM:46 612219

Aliases & Classifications for Neuroepithelioma

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42NIH Rare Diseases, 46OMIM, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroepithelioma 42 46 44
neuroectodermal tumors 60


Related Diseases for Neuroepithelioma

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17GeneCards, 18GeneDecks
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Diseases related to Neuroepithelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 242)
idRelated DiseaseScoreTop Affiliating Genes
1medulloblastoma31.1NGF, ENO2, LIF, MYC, MYCN
2cerebral primitive neuroectodermal tumor30.9MYC, MYCN
3neuroblastoma30.6CHAT, MYC, ENO2, MYCN, NGF
4sarcoma30.6FLI1, KITLG, ENO2, MYCN, CD99, EWSR1
5peripheral primitive neuroectodermal tumor30.5ENO2, CD99, FLI1, EWSR1
6childhood medulloblastoma30.5MYC, MYCN
7pancreatitis30.4CCK, KITLG
8neuroendocrine tumor30.4MYCN, ENO2, CCK, GRP, NPY
9astrocytoma30.3NGF
10synovial sarcoma30.3CD99, EWSR1, FLI1
11leukemia30.3EWSR1, UGCG, FLI1, LIF, KITLG, CD99
12fibrous histiocytoma30.2EWSR1
13merkel cell carcinoma30.2ENO2
14stomach cancer30.1MYCN, MYC, LIF, CD99, GRP
15olfactory neuroblastoma30.1FLI1, ENO2, CD99
16paraganglioma29.9ENO2, GRP
17angiosarcoma29.9CHAT, FLI1
18malignant glioma29.9GRP, ENO2
19osteosarcoma29.9NGF, MYCN, MYC
20myeloid leukemia29.9LIF, MYC, KITLG
21duodenal ulcer29.9CCK, GRP
22squamous cell carcinoma29.9ENO2, PCSK2, UGCG, LIF, MYC, GRP
23melanoma29.9MYC, GRP, ENO2, DDC, FLI1, EWSR1
24pheochromocytoma29.9NGF, NPY, DDC, LIF, CHAT, MYCN
25meningioma29.9DRD1
26hepatitis29.9MYCN, CD99, DDC
27rhabdomyosarcoma29.9ENO2, MYCN, EWSR1, FLI1, CD99
28retinoblastoma29.8ENO2, MYCN, MYC, NGF
29melanotic neuroectodermal tumor11.1
30supratentorial primitive neuroectodermal tumor10.9
31cerebritis10.6
32intracranial primitive neuroectodermal tumor10.5
33kidney sarcoma10.5
34primitive neuroectodermal tumor10.4
35atypical teratoid rhabdoid tumor10.4
36soft tissue peripheral neuroepithelioma10.3
37cervicitis10.3
38extraosseous ewing's sarcoma10.3
39prostatitis10.3
40cerebellopontine angle primitive neuroectodermal10.3
41pineoblastoma10.3
42thyroiditis10.3
43vulvar sarcoma10.3
44bone peripheral neuroepithelioma10.3
45unilateral retinoblastoma10.2
46localized peripheral primitive neuroectodermal tumor10.2
47cerebellopontine angle tumor10.2
48cystic teratoma10.2
49embryonal rhabdomyosarcoma10.2
50mature teratoma10.2

Graphical network of the top 20 diseases related to Neuroepithelioma:



Diseases related to neuroepithelioma

Clinical Features for Neuroepithelioma

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46OMIM
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Clinical features from OMIM:

612219

Drugs & Therapeutics for Neuroepithelioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Neuroepithelioma

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Anatomical Context for Neuroepithelioma

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32MalaCards
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MalaCards organs/tissues related to Neuroepithelioma:

32
Adrenal gland

Animal Models for Neuroepithelioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neuroepithelioma:

36 (show all 16)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537510.2ADRB1, LIF, EWSR1
2MP:000538010.1EDN1
3MP:00053699.9DRD1, FLI1, CHAT, MYC, MYCN, NGF
4MP:00053799.9CCK, EWSR1, LIF, MYC, PCSK2, KITLG
5MP:00053819.8NPY, DRD1, EDN1, LIF, MYC, MYCN
6MP:00053909.7EWSR1, NPY, EDN1, LIF, CHAT, MYC
7MP:00107719.7EWSR1, DRD1, LIF, MYC, NGF, PCSK2
8MP:00053709.7NPY, FLI1, LIF, MYC, MYCN, KITLG
9MP:00028739.7EWSR1, NPY, DRD1, EDN1, UGCG, CHAT
10MP:00036319.6ENO2, CCK, NPY, DRD1, EDN1, DDC
11MP:00053869.4NPY, DRD1, UGCG, DDC, LIF, CHAT
12MP:00053859.4LIF, DDC, FLI1, EDN1, DRD1, CHAT
13MP:00053849.3EWSR1, DRD1, UGCG, FLI1, DDC, LIF
14MP:00053789.3EWSR1, NPY, DRD1, UGCG, FLI1, DDC
15MP:00053769.2DDC, UGCG, EDN1, DRD1, NPY, CCK
16MP:00107689.1DDC, FLI1, UGCG, EDN1, DRD1, EWSR1

Publications for Neuroepithelioma

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Genetic Variations for Neuroepithelioma

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Expression for genes affiliated with Neuroepithelioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroepithelioma

Search GEO for disease gene expression data for Neuroepithelioma.

Pathways for genes affiliated with Neuroepithelioma

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12EMD Millipore, 59Tocris Bioscience, 49PharmGKB, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 4Cell Signaling Technology
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Compounds for genes affiliated with Neuroepithelioma

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Neuroepithelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.7MYCN
2askin4410.4EWSR1, ENO2, NGF
3forskolin44 49 1112.4CCK, NPY, CHAT, ADRB1, ENO2
4nmda44 2811.4CHAT, GRP, NGF, ADRB1
5homovanillic acid44 2411.3MYCN, ENO2, CHAT, DDC
6oxyntomodulin44 5911.3GRP, PCSK2, CCK, NPY
7atropine44 28 1112.3GRP, DRD1, NPY, NGF, CCK
86-hydroxydopamine4410.2NPY, NGF, MYC, DDC, CHAT, DRD1
9phenylephrine44 28 11 2413.2LIF, NPY, EDN1, NGF, ADRB1
10glutamate4410.2ADRB1, CHAT, DDC, DRD1, NPY, CCK
11cyclo(his-pro)4410.2NPY, GRP, CCK
12cocaine44 1111.2NGF, GRP, CHAT, CCK, DRD1, NPY
13tetrodotoxin44 59 2812.2ENO2, GRP, EDN1, NPY, CCK
14acetylcholine44 49 28 11 2414.2GRP, CHAT, ENO2, NGF, CCK, DRD1
15phosphoramidon44 1111.2CCK, NPY, EDN1, GRP
16catecholamine4410.2DDC, CHAT, DRD1, MYCN, ADRB1, NPY
17serine4410.1DRD1, UGCG, LIF, PCSK2, MYCN, ADRB1
18ibmx44 28 5912.1ENO2, GRP, PCSK2, EDN1, CCK, DRD1
19carbachol44 28 1112.1GRP, LIF, EDN1, DRD1, NPY, CCK
20dbc-amp4410.1ENO2, CHAT, LIF, MYCN, NGF
215-hydroxytryptamine4410.1CCK, CHAT, DDC, ENO2, NPY, EDN1
22gaba4410.1ENO2, GRP, CHAT, DDC, DRD1, NPY
23epinephrine44 11 2412.1NPY, EDN1, DDC, ADRB1, NGF, KITLG
24choline44 11 2412.0DDC, LIF, NPY, GRP, NGF, CHAT
25histamine44 28 2412.0CCK, NGF, GRP, DDC, EDN1, NPY
26acth4410.0NPY, CCK, LIF, ENO2, PCSK2, GRP
27pd 98,059449.9KITLG, ENO2, NGF, LIF, EDN1, MYC
28genistein44 28 59 2 11 2414.9DRD1, MYCN, EDN1, LIF, KITLG, NGF
29dopamine44 28 11 2412.9CHAT, ADRB1, ENO2, MYCN, LIF, DRD1
30cyclic amp44 2410.9NGF, PCSK2, EWSR1, NPY, DRD1, LIF
31adenylate449.9NPY, DRD1, GRP, ENO2, ADRB1, NGF
32actinomycin d449.9LIF, KITLG, NGF, MYCN, MYC, EDN1
33glucose449.9ADRB1, PCSK2, CHAT, UGCG, KITLG, NPY
34gf 109203x44 5910.9NPY, NGF, EDN1, GRP, KITLG
35arginine449.9EDN1, LIF, GRP, NGF, PCSK2, ADRB1
36nitric oxide44 11 2411.8ADRB1, NPY, EDN1, LIF, CHAT, MYCN
37cyclosporin a44 28 5911.8EDN1, CCK, UGCG, LIF, KITLG, NGF
38lactate449.7LIF, CHAT, GRP, MYCN, NPY, ENO2
39paraffin449.7KITLG, MYCN, MYC, GRP, CHAT, LIF
40vegf449.7EDN1, LIF, GRP, MYCN, CD99, KITLG
41alanine449.7KITLG, NGF, GRP, ADRB1, ENO2, DDC
42testosterone44 59 11 2412.7CCK, ENO2, KITLG, NGF, GRP, NPY
43dexamethasone44 49 28 1112.7ADRB1, ENO2, CCK, LIF, CHAT, GRP
44sodium nitroprusside449.6NPY, EDN1, CHAT, MYC, CCK
45cisplatin44 49 59 1112.6ENO2, KITLG, MYCN, MYC, GRP, LIF
46norepinephrine44 11 2411.5DRD1, CHAT, LIF, DDC, EDN1, NPY
47thymidine44 2410.5NGF, ENO2, MYC, KITLG, GRP, EDN1
48calcium44 49 11 2412.4CHAT, LIF, EDN1, DRD1, EWSR1, NPY
49retinoic acid44 2410.3EWSR1, KITLG, PCSK2, NGF, MYCN, MYC
50tyrosine449.2MYC, CCK, EWSR1, NPY, DRD1, MYCN

GO Terms for genes affiliated with Neuroepithelioma

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16Gene Ontology
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Cellular components related to Neuroepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:04320410.1ENO2, PCSK2, CCK
2extracellular spaceGO:0056159.2KITLG, CCK, NPY, EDN1, LIF, GRP

Biological processes related to Neuroepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1rhythmic excitationGO:04317910.4CHAT, EDN1
2elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.3EDN1, DRD1
3memoryGO:00761310.2ADRB1, NGF, DRD1
4sensory perception of painGO:01923310.2EDN1, NGF, ADRB1
5positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.0KITLG, LIF, CCK
6negative regulation of hormone secretionGO:04688810.0LIF, EDN1

Molecular functions related to Neuroepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.3ADRB1, DRD1
2neuropeptide hormone activityGO:0051849.8GRP, NPY, CCK

Products for genes affiliated with Neuroepithelioma

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  • Antibodies
  • Proteins
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Sources for Neuroepithelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet