MCID: NRP002
MIFTS: 49

Neuroepithelioma malady

Neuronal, Cancer categories

Summaries for Neuroepithelioma

Sources:
64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Neuroblastoma (NB) is the most common extracranial solid cancer in childhood and the most common cancer... more...

MalaCards: Neuroepithelioma, also known as neuroectodermal tumors, is related to cerebral primitive neuroectodermal tumor and childhood medulloblastoma. An important gene associated with Neuroepithelioma is EWSR1 (EWS RNA-binding protein 1), and among its related pathways are Selected targets of CREB1 and Notch Pathway. The compounds cycloheximide and askin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and kidney, and related mouse phenotypes are adipose tissue and embryogenesis.

Description from OMIM:47 612219

Aliases & Classifications for Neuroepithelioma

Sources:
43NIH Rare Diseases, 47OMIM, 45Novoseek, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Aliases & Descriptions:

neuroepithelioma 43 47 45
neuroectodermal tumors 61


Related Diseases for Neuroepithelioma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Neuroepithelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 212)
idRelated DiseaseScoreTop Affiliating Genes
1cerebral primitive neuroectodermal tumor31.0MYC, MYCN
2childhood medulloblastoma30.6MYC, MYCN
3astrocytoma30.3NGF
4synovial sarcoma30.3CD99, EWSR1, FLI1
5fibrous histiocytoma30.2EWSR1
6merkel cell carcinoma30.2ENO2
7stomach cancer30.2MYCN, MYC, LIF, CD99, GRP
8olfactory neuroblastoma30.1FLI1, ENO2, CD99
9paraganglioma30.0ENO2, GRP
10angiosarcoma30.0CHAT, FLI1
11lymphoblastic lymphoma30.0FLI1, CD99, ENO2
12wilms tumor30.0ENO2, EWSR1, FLI1, MYCN
13duodenal ulcer30.0CCK, GRP
14squamous cell carcinoma30.0ENO2, PCSK2, UGCG, LIF, MYC, GRP
15pheochromocytoma30.0NGF, NPY, DDC, LIF, CHAT, MYCN
16extraskeletal ewing sarcoma29.9EWSR1, CD99
17teratoma29.9CD99, LIF, ENO2
18melanotic neuroectodermal tumor11.1
19supratentorial primitive neuroectodermal tumor10.9
20intracranial primitive neuroectodermal tumor10.6
21rhabdoid tumor10.5
22n syndrome10.5
23atypical teratoid rhabdoid tumor10.4
24soft tissue peripheral neuroepithelioma10.4
25supratentorial primitive neuroectodermal tumors, childhood10.4
26bone peripheral neuroepithelioma10.3
27cerebellopontine angle primitive neuroectodermal10.3
28vagina sarcoma10.3
29vulvar sarcoma10.3
30unilateral retinoblastoma10.2
31localized peripheral primitive neuroectodermal tumor10.2
32ependymoma10.2
33malignant peripheral neuroectodermal tumor of the cervix uteri10.2
34trilateral retinoblastoma10.2
35ovarian cystic teratoma10.2
36pediatric ependymoma10.2
37ganglioglioma10.2
38gastrointestinal stromal tumor10.2
39penis sarcoma10.2
40clear cell sarcoma10.2
41cauda equina syndrome10.2
42acute leukemia10.2
43brain medulloblastoma10.2
44pineoblastoma, childhood10.2
45desmoplastic small round cell tumor10.2
46embryonal tumor with multilayered rosettes10.2
47heart tumor10.2
48nonseminomatous germ cell tumor10.2
49germ cell tumors10.2
50malignant peripheral neuroectodermal tumor of the corpus uteri10.2

Graphical network of the top 20 diseases related to Neuroepithelioma:



Diseases related to neuroepithelioma

Clinical Features for Neuroepithelioma

Sources:
47OMIM
See all sources

Clinical features from OMIM:

612219

Drugs & Therapeutics for Neuroepithelioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Neuroepithelioma

Drug clinical trials:

Search ClinicalTrials for Neuroepithelioma

Search NIH Clinical Center for Neuroepithelioma

Search CenterWatch for Neuroepithelioma

Genetic Tests for Neuroepithelioma

Anatomical Context for Neuroepithelioma

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Neuroepithelioma:

33
Spinal cord, Brain, Kidney, Uterus, Cerebellum, Colon, Adrenal gland, Cervix, T cells, Pineal

Animal Models for Neuroepithelioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Neuroepithelioma

Sources:
51PubMed
See all sources

Articles related to Neuroepithelioma:

(show top 50)    (show all 126)
idTitleAuthorsYear
1
Collision tumor of the stomach: an unusual combination of adenocarcinoma and immature "neuroepitheliomatous" teratoma. (22142638)
2012
2
Hepatitis C virus infection of neuroepithelioma cell lines. (20538002)
2010
3
Paraneoplastic cerebellar degeneration in olfactory neuroepithelioma. (16361612)
2006
4
Evidence against a direct effect of leptin on insulin-like growth factor-I (IGF-I), IGFBP-2 and IGF-I receptor expression in human SK-N-MC neuroepithelioma cells. (15932773)
2005
5
Signalling pathways involved in the chemotactic activity of CXCL12 in cultured rat cerebellar neurons and CHP100 neuroepithelioma cells. (12576222)
2003
6
Antisense to glucosylceramide synthase in human neuroepithelioma affects cell growth but not apoptosis. (12032678)
2002
7
Olfactory neuroepithelioma in a dog: an immunohistochemical and electron microscopic study. (12014590)
2002
8
Regulation of human beta(1)-adrenergic receptors and their mRNA in neuroepithelioma SK-N-MC cells: effects of agonist, forskolin, and protein kinase A. (11705454)
2001
9
Olfactory neuroepithelioma arising from the olfactory placode. (10774945)
2000
10
N-Oleoylethanolamine inhibits glucosylation of natural ceramides in CHP-100 neuroepithelioma cells: possible implications for apoptosis. (10049730)
1999
11
An autopsy case of peripheral neuroepithelioma in posterior mediastinum with p53 point mutation. (9617873)
1998
12
Olfactory esthesioneuroblastoma (olfactory neuroblastoma/olfactory neuroepithelioma). (9846465)
1998
13
Potentiation of G-protein-coupled receptor-induced MAP kinase activation by exogenous EGF receptors in SK-N-MC neuroepithelioma cells. (9790898)
1998
14
Is the deletion of the short arm of chromosome 1 a prognostic factor in pediatric peripheral primitive neuroepithelioma (PNET)? (8531854)
1996
15
Malignant neuroepithelioma of the colon. (7720900)
1995
16
Physical and biological characterization of a growth-inhibitory activity purified from the neuroepithelioma cell line A673. (7826358)
1995
17
The establishment and characterization of a peripheral neuroepithelioma cell line in soft tissue of extremity. (7853855)
1995
18
Interphase molecular cytogenetics of Ewing's sarcoma and peripheral neuroepithelioma t(11;22) with flanking and overlapping cosmid probes. (8194041)
1994
19
Regulation of CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC in response to second messenger activators. (7694875)
1993
20
Peripheral neuroepithelioma of the soft tissues. A retrospective analysis of fifteen pediatric patients. (8328643)
1993
21
Use of HBA 71 and anti-beta 2-microglobulin to distinguish peripheral neuroepithelioma from neuroblastoma. (8375858)
1993
22
Fine needle aspiration of peripheral neuroepithelioma of soft tissues. (1542998)
1992
23
Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoints. (1283315)
1992
24
Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines. (1741160)
1992
25
Cyclic AMP potentiates receptor-stimulated phosphoinositide hydrolysis in human neuroepithelioma cells. (1355263)
1992
26
Retinoblastoma, microphthalmia, coloboma, and neuroepithelioma of the pineal body. (1416626)
1992
27
Case report 682. Neuroepithelioma of soft tissues of the knee. (1896883)
1991
28
Identification of multiple phosphoinositide-linked receptors on human SK-N-MC neuroepithelioma cells. (1681032)
1991
29
Antisense inhibition of N-myc reduces cell growth but does not affect c-myc expression in the neuroepithelioma cell line CHP100. (2068146)
1991
30
Importance of phenotypic and molecular characterization for identification of a neuroepithelioma tumor cell line, NUB-20. (2158399)
1990
31
t(11;22) in three cases of peripheral neuroepithelioma. (2278971)
1990
32
Expression of the cholecystokinin gene by cultured human primitive neuroepithelioma cell lines. (2753982)
1989
33
Peripheral primitive neuroectodermal tumor (peripheral neuroepithelioma) in children. A review of the St. Jude experience and controversies in diagnosis and management. (2551479)
1989
34
Case 3. Primitive neuroectodermal tumor-peripheral neuroepithelioma. (2748481)
1989
35
Primary peripheral neuroepithelioma of the orbit with intracranial extension. (3191459)
1988
36
Two new cases of primary peripheral neuroepithelioma of soft tissue with translocation t(11;22)(q24;q12). (3164249)
1988
37
Peripheral neuroepithelioma in childhood. Immunohistochemical demonstration of epithelial differentiation. (3178431)
1988
38
Treatment of peripheral neuroepithelioma in children and young adults. (3316513)
1987
39
Peripheral neuroepithelioma: genetic analysis of tumor derived cell lines. (3991729)
1985
40
Peripheral neuroepithelioma in childhood. (6498781)
1984
41
Congenital primitive neuroectodermal tumor (neuroepithelioma) of the chest wall. (7110059)
1982
42
Neuroepithelioma--a rare malignant peripheral nerve tumor of primitive origin: report of two new cases and a review of the literature. (6170419)
1981
43
Peripheral neuroepithelioma: a light and electron microscopic study. (7438020)
1980
44
Malignant neuroepithelioma in childhood. A report of three cases. (5372849)
1969
45
NEUROEPITHELIOMA OF THE ORBIT. (14288946)
1965
46
Olfactory neuroepithelioma (neuroblastoma). (13649039)
1959
47
Neuroepithelioma; its place in the histogenetic classification of primary neuroectodermal brain tumors. (13097186)
1953
48
Neuroepithelioma of the stomach. (20265999)
1947
49
Intraorbital melanosis and intracranial neuroepithelioma of the optic nerve. (20990384)
1946
50
Recurrent Neuroepithelioma. (16692415)
1917

Genetic Variations for Neuroepithelioma

Expression for genes affiliated with Neuroepithelioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Neuroepithelioma

Search GEO for disease gene expression data for Neuroepithelioma.

Pathways for genes affiliated with Neuroepithelioma

Sources:
12EMD Millipore, 60Tocris Bioscience, 50PharmGKB, 38NCBI BioSystems Database, 54Reactome, 30KEGG, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Neuroepithelioma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Neuroepithelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.7MYCN
2askin4510.4EWSR1, ENO2, NGF
3forskolin45 50 1112.4CCK, NPY, CHAT, ADRB1, ENO2
4nmda45 2911.4CHAT, GRP, NGF, ADRB1
5homovanillic acid45 2411.3MYCN, ENO2, CHAT, DDC
6oxyntomodulin45 6011.3GRP, PCSK2, CCK, NPY
7atropine45 29 1112.3GRP, DRD1, NPY, NGF, CCK
86-hydroxydopamine4510.2NPY, NGF, MYC, DDC, CHAT, DRD1
9phenylephrine45 29 11 2413.2LIF, NPY, EDN1, NGF, ADRB1
10glutamate4510.2ADRB1, CHAT, DDC, DRD1, NPY, CCK
11cyclo(his-pro)4510.2NPY, GRP, CCK
12cocaine45 1111.2NGF, GRP, CHAT, CCK, DRD1, NPY
13tetrodotoxin45 60 2912.2ENO2, GRP, EDN1, NPY, CCK
14acetylcholine45 50 29 11 2414.2GRP, CHAT, ENO2, NGF, CCK, DRD1
15phosphoramidon45 1111.2CCK, NPY, EDN1, GRP
16catecholamine4510.2DDC, CHAT, DRD1, MYCN, ADRB1, NPY
17serine4510.1DRD1, UGCG, LIF, PCSK2, MYCN, ADRB1
18ibmx45 29 6012.1ENO2, GRP, PCSK2, EDN1, CCK, DRD1
19carbachol45 29 1112.1GRP, LIF, EDN1, DRD1, NPY, CCK
20dbc-amp4510.1ENO2, CHAT, LIF, MYCN, NGF
215-hydroxytryptamine4510.1CCK, CHAT, DDC, ENO2, NPY, EDN1
22gaba4510.1ENO2, GRP, CHAT, DDC, DRD1, NPY
23epinephrine45 11 2412.1NPY, EDN1, DDC, ADRB1, NGF, KITLG
24choline45 11 2412.0DDC, LIF, NPY, GRP, NGF, CHAT
25histamine45 29 2412.0CCK, NGF, GRP, DDC, EDN1, NPY
26acth4510.0NPY, CCK, LIF, ENO2, PCSK2, GRP
27pd 98,059459.9KITLG, ENO2, NGF, LIF, EDN1, MYC
28genistein45 29 60 2 11 2414.9DRD1, MYCN, EDN1, LIF, KITLG, NGF
29dopamine45 29 11 2412.9CHAT, ADRB1, ENO2, MYCN, LIF, DRD1
30cyclic amp45 2410.9NGF, PCSK2, EWSR1, NPY, DRD1, LIF
31adenylate459.9NPY, DRD1, GRP, ENO2, ADRB1, NGF
32actinomycin d459.9LIF, KITLG, NGF, MYCN, MYC, EDN1
33glucose459.9ADRB1, PCSK2, CHAT, UGCG, KITLG, NPY
34gf 109203x45 6010.9NPY, NGF, EDN1, GRP, KITLG
35arginine459.9EDN1, LIF, GRP, NGF, PCSK2, ADRB1
36nitric oxide45 11 2411.8ADRB1, NPY, EDN1, LIF, CHAT, MYCN
37cyclosporin a45 29 6011.8EDN1, CCK, UGCG, LIF, KITLG, NGF
38lactate459.7LIF, CHAT, GRP, MYCN, NPY, ENO2
39paraffin459.7KITLG, MYCN, MYC, GRP, CHAT, LIF
40vegf459.7EDN1, LIF, GRP, MYCN, CD99, KITLG
41alanine459.7KITLG, NGF, GRP, ADRB1, ENO2, DDC
42testosterone45 60 11 2412.7CCK, ENO2, KITLG, NGF, GRP, NPY
43dexamethasone45 50 29 1112.7ADRB1, ENO2, CCK, LIF, CHAT, GRP
44sodium nitroprusside459.6NPY, EDN1, CHAT, MYC, CCK
45cisplatin45 50 60 1112.6ENO2, KITLG, MYCN, MYC, GRP, LIF
46norepinephrine45 11 2411.5DRD1, CHAT, LIF, DDC, EDN1, NPY
47thymidine45 2410.5NGF, ENO2, MYC, KITLG, GRP, EDN1
48calcium45 50 11 2412.4CHAT, LIF, EDN1, DRD1, EWSR1, NPY
49retinoic acid45 2410.3EWSR1, KITLG, PCSK2, NGF, MYCN, MYC
50tyrosine459.2MYC, CCK, EWSR1, NPY, DRD1, MYCN

GO Terms for genes affiliated with Neuroepithelioma

Sources:
16Gene Ontology
See all sources

Cellular components related to Neuroepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1perikaryonGO:04320410.1ENO2, PCSK2, CCK
2extracellular spaceGO:0056159.2KITLG, CCK, NPY, EDN1, LIF, GRP

Biological processes related to Neuroepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1rhythmic excitationGO:04317910.4CHAT, EDN1
2elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.3EDN1, DRD1
3memoryGO:00761310.2ADRB1, NGF, DRD1
4sensory perception of painGO:01923310.2EDN1, NGF, ADRB1
5positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.0KITLG, LIF, CCK
6negative regulation of hormone secretionGO:04688810.0LIF, EDN1

Molecular functions related to Neuroepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.3ADRB1, DRD1
2neuropeptide hormone activityGO:0051849.8GRP, NPY, CCK

Products for genes affiliated with Neuroepithelioma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Neuroepithelioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet