MCID: NRP002
MIFTS: 46

Neuroepithelioma malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Neuroepithelioma

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65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Neuroblastoma (NB) is the most common extracranial solid cancer in childhood and the most common cancer... more...

MalaCards: Neuroepithelioma, also known as neuroectodermal tumors, is related to peripheral primitive neuroectodermal tumor and neuroblastoma. An important gene associated with Neuroepithelioma is EWSR1 (EWS RNA-binding protein 1), and among its related pathways are Transcription CREB pathway and Monoamine GPCRs. The compounds noradrenaline and phenylpropanolamine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, brain and bone, and related mouse phenotypes are endocrine/exocrine gland and normal.

Description from OMIM:47 612219

Aliases & Classifications for Neuroepithelioma

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43NIH Rare Diseases, 47OMIM, 45Novoseek, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

neuroepithelioma 43 47 45
neuroectodermal tumors 62


Related Diseases for Neuroepithelioma

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17GeneCards, 18GeneDecks
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Diseases related to Neuroepithelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 47)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral primitive neuroectodermal tumor30.6MYCN, EWSR1
2neuroblastoma10.5
3sarcoma10.5
4primitive neuroectodermal tumor10.5
5soft tissue peripheral neuroepithelioma10.2
6bone peripheral neuroepithelioma10.2
7neuronitis10.1
8cerebral primitive neuroectodermal tumor10.1EWSR1
9embryonal rhabdomyosarcoma10.1EWSR1, MYCN
10thyroid medullary carcinoma10.0MYCN, CCK
11psychotic disorder10.0DRD1, CCK
12ganglioneuroblastoma10.0NPY, MYCN
13bulimia nervosa10.0NPY, CCK
14autonomic neuropathy10.0NPY, CCK
15ganglioneuroma10.0NPY, MYCN
16eating disorder10.0NPY, CCK
17anxiety disorder10.0CCK, NPY
18respiratory failure10.0NPY, CCK
19prader-willi syndrome10.0NPY, CCK
20alcohol dependence10.0DRD1, NPY
21anorexia nervosa10.0NPY, CCK
22congestive heart failure10.0NPY, ADRB1
23mood disorder10.0DRD1, NPY
24essential hypertension10.0NPY, DRD1, ADRB1
25huntington's disease10.0DRD1, NPY
26neuroendocrine tumor10.0MYCN, CCK, NPY
27hepatitis c10.0
28olfactory neuroblastoma10.0
29microphthalmia10.0
30coloboma10.0
31hepatitis10.0
32meningioma10.0
33retinoblastoma10.0
34rhabdomyosarcoma10.0
35transitional cell carcinoma10.0
36cerebellar degeneration10.0
37paraneoplastic cerebellar degeneration10.0
38hepatitis c virus10.0
39teratoma10.0
40glaucoma10.0NPY, ADRB1
41embryonal cancer10.0LIF, MYCN
42schizophrenia10.0CCK, DRD1, NPY
43congenital heart disease9.9LIF, ADRB1, NPY
44pheochromocytoma9.9MYCN, LIF, NPY
45obesity9.9LIF, ADRB1, CCK, NPY
46malignant glioma9.9MYCN, LIF, ADRB1, NPY
47alzheimer's disease9.9LIF, CCK, DRD1, NPY

Graphical network of the top 20 diseases related to Neuroepithelioma:



Diseases related to neuroepithelioma

Symptoms for Neuroepithelioma

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47OMIM
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Clinical features from OMIM:

612219

Drugs & Therapeutics for Neuroepithelioma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Neuroepithelioma

Search NIH Clinical Center for Neuroepithelioma

Genetic Tests for Neuroepithelioma

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Anatomical Context for Neuroepithelioma

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33MalaCards
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MalaCards organs/tissues related to Neuroepithelioma:

33
Adrenal gland, Brain, Bone, Pineal, Cervix, Colon, Uterus, Kidney, Spinal cord, Cerebellum

Animal Models for Neuroepithelioma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Neuroepithelioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2EWSR1, LIF, ADRB1, CCK
2MP:00028738.2EWSR1, MYCN, DRD1, NPY
3MP:00053818.1NPY, DRD1, LIF, MYCN
4MP:00053698.1EWSR1, MYCN, LIF, ADRB1, DRD1
5MP:00053758.0NPY, DRD1, ADRB1, LIF, EWSR1
6MP:00107687.9DRD1, ADRB1, LIF, MYCN, EWSR1
7MP:00053907.9EWSR1, MYCN, LIF, ADRB1, NPY
8MP:00036317.5MYCN, LIF, CCK, DRD1, NPY
9MP:00053787.4EWSR1, MYCN, LIF, ADRB1, DRD1, NPY
10MP:00053767.2MYCN, LIF, ADRB1, CCK, DRD1, NPY

Publications for Neuroepithelioma

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52PubMed
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Articles related to Neuroepithelioma:

(show top 50)    (show all 124)
idTitleAuthorsYear
1
Solitary epidural brain metastasis of a peripheral neuroepithelioma (a primitive neuroectodermal tumor): a case report. (22470583)
2008
2
Polyphenotypic peripheral neuroepithelioma occuring in the foot: a case report. (17474251)
2007
3
Paraneoplastic cerebellar degeneration in olfactory neuroepithelioma. (16361612)
2006
4
Olfactory neuroepithelioma: an immunohistochemical and ultrastructural study. (17080716)
2006
5
Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. (12873973)
2003
6
Antisense to glucosylceramide synthase in human neuroepithelioma affects cell growth but not apoptosis. (12032678)
2002
7
Peripheral neuroepithelioma with ganglion cells: report of two cases and review of the literature. (9841705)
1999
8
An autopsy case of peripheral neuroepithelioma in posterior mediastinum with p53 point mutation. (9617873)
1998
9
Collision tumor: a peripheral neuroepithelioma and a transitional-cell carcinoma occurring simultaneously in the renal pelvis. (9869830)
1997
10
Retinoic acid-induced regulation of neuropeptide Y receptor expression and function in the neuroepithelioma line SK-N-MC. (9165460)
1997
11
Paracrine mediation of calcium signaling in human SK-N-MCIXC neuroepithelioma cells. (8760029)
1996
12
Intra- and intercellular calcium signaling in human neuroepithelioma cells. (8906559)
1996
13
Immunohistochemical profile of monoclonal antibody O13: antibody that recognizes glycoprotein p30/32MIC2 and is useful in diagnosing Ewing's sarcoma and peripheral neuroepithelioma. (7513503)
1994
14
Second messenger activators regulate CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC. (7514375)
1994
15
Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma. (8439553)
1993
16
Regulation of CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC in response to second messenger activators. (7694875)
1993
17
Peripheral neuroepithelioma of the soft tissues. A retrospective analysis of fifteen pediatric patients. (8328643)
1993
18
Use of HBA 71 and anti-beta 2-microglobulin to distinguish peripheral neuroepithelioma from neuroblastoma. (8375858)
1993
19
Fine needle aspiration of peripheral neuroepithelioma of soft tissues. (1542998)
1992
20
Unicolor and bicolor in situ hybridization in the diagnosis of peripheral neuroepithelioma and related tumors. (1384659)
1992
21
Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoints. (1283315)
1992
22
Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines. (1741160)
1992
23
Cyclic AMP potentiates receptor-stimulated phosphoinositide hydrolysis in human neuroepithelioma cells. (1355263)
1992
24
Peripheral neuroepithelioma: a light microscopic, immunocytochemical, and ultrastructural study. (1371873)
1992
25
Case report 682. Neuroepithelioma of soft tissues of the knee. (1896883)
1991
26
Adult peripheral neuroepithelioma in Meckel's cave. (1997905)
1991
27
Identification of multiple phosphoinositide-linked receptors on human SK-N-MC neuroepithelioma cells. (1681032)
1991
28
Characterization and regulation of beta 1-adrenergic receptors in a human neuroepithelioma cell line. (1671088)
1991
29
The cholecystokinin gene is abundantly co-expressed with gastrin-releasing peptide, enkephalin and neuropeptide Y genes in a clonal human neuroepithelioma cell line. (2384178)
1990
30
Nerve growth factor-induced differentiation of human neuroblastoma and neuroepithelioma cell lines. (1964795)
1990
31
Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line. (2205380)
1990
32
A case of malignant neuroepithelioma in the retroperitoneum]. (2407879)
1990
33
Neuropeptide Y binding and inhibition of cAMP accumulation in human neuroepithelioma cells. (2159234)
1990
34
Peripheral neuroectodermal sarcoma of soft tissue (peripheral neuroepithelioma): a pathologic study of ten cases with differential diagnosis regarding other small, round-cell sarcomas. (2656493)
1989
35
Spontaneous olfactory neuroepithelioma in a domestic medaka (Oryzias latipes). (2720659)
1989
36
Expression of the cholecystokinin gene by cultured human primitive neuroepithelioma cell lines. (2753982)
1989
37
Primary peripheral neuroepithelioma of the orbit with intracranial extension. (3191459)
1988
38
Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepithelioma. (3390826)
1988
39
Treatment of peripheral neuroepithelioma in children and young adults. (3316513)
1987
40
Neuroepithelioma (neuroblastoma) arising in an adult. A case report. (4044631)
1985
41
Extraskeletal Ewing's sarcoma (peripheral neuroepithelioma). (4089998)
1985
42
Peripheral neuroepithelioma in childhood. (6498781)
1984
43
Chromosome translocation in peripheral neuroepithelioma. (6749231)
1984
44
Olfactory neuroepithelioma in a cynomolgus monkey (Macaca fascicularis). (1123841)
1975
45
Malignant neuroepithelioma in childhood. A report of three cases. (5372849)
1969
46
Tumors in amphibians. I. Histology of a neuroepithelioma in Siredon mexicanum. (4163837)
1967
47
Olfactory neuroepithelioma. Report of a case (13853935)
1959
48
Neuroepithelioma; its place in the histogenetic classification of primary neuroectodermal brain tumors. (13097186)
1953
49
Intraorbital melanosis and intracranial neuroepithelioma of the optic nerve. (20990384)
1946
50
Neuroepithelioma of the Cerebellum. (19969839)
1929

Variations for Neuroepithelioma

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Expression for genes affiliated with Neuroepithelioma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neuroepithelioma

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Pathways for genes affiliated with Neuroepithelioma

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50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 51PharmGKB, 12EMD Millipore, 5Cell Signaling Technology, 30KEGG
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Compounds for genes affiliated with Neuroepithelioma

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29IUPHAR, 45Novoseek, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 3BitterDB
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Compounds related to Neuroepithelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1noradrenaline2910.0DRD1, ADRB1
2phenylpropanolamine45 24 1112.0ADRB1, DRD1
3raclopride45 2910.9CCK, DRD1
4asenapine29 1110.9ADRB1, DRD1
5[met]enkephalin459.8NPY, CCK
6cyclo(his-pro)459.7CCK, NPY
7octadecaneuropeptide459.7CCK, NPY
8sulpiride45 29 1111.7NPY, DRD1
9bethanechol45 29 1111.7CCK, NPY
10enterostatin459.7CCK, NPY
11npff459.7CCK, NPY
12alpha msh459.7CCK, NPY
13incretin459.7NPY, CCK
14prazosin45 29 51 1112.6NPY, ADRB1
15muscimol45 61 2911.6NPY, DRD1
16fenfluramine45 29 1111.6CCK, NPY
17nicardipine45 29 1111.6CCK, DRD1
18oxyntomodulin45 6110.6NPY, CCK
19orlistat45 61 1111.6NPY, CCK
20phosphoramidon45 1110.4CCK, NPY
21methamphetamine45 51 1111.4NPY, DRD1
22amphetamine45 51 1111.3NPY, DRD1, CCK
23atropine45 29 1111.3NPY, DRD1, CCK
24opiate459.3CCK, DRD1, NPY
25cocaine45 1110.3NPY, DRD1, CCK
26naloxone45 29 51 1112.2DRD1, CCK
27gaba459.2NPY, DRD1, CCK
28nmda45 2910.1NPY, DRD1, ADRB1
29phenylephrine45 29 24 1112.0LIF, ADRB1, NPY
30isoproterenol45 1110.0NPY, ADRB1, LIF
31catecholamine458.9MYCN, ADRB1, DRD1, NPY
32glutamine458.9NPY, CCK, EWSR1
33adenylate458.9NPY, DRD1, CCK, ADRB1
34acth458.8LIF, CCK, NPY
35glutamate458.8ADRB1, CCK, DRD1, NPY
36genistein45 29 61 3 24 1113.7MYCN, LIF, DRD1
37paraffin458.5EWSR1, MYCN, LIF, NPY
38carbachol45 29 1110.5NPY, DRD1, CCK, LIF
39acetylcholine45 51 29 24 1112.5LIF, CCK, DRD1, NPY
40glucose458.3LIF, ADRB1, CCK, NPY
41serine458.3EWSR1, MYCN, LIF, ADRB1, DRD1
42cyclic amp45 249.2EWSR1, LIF, ADRB1, DRD1, NPY
43arginine458.2NPY, CCK, ADRB1, LIF, EWSR1
44norepinephrine45 24 1110.1LIF, ADRB1, CCK, DRD1, NPY
45forskolin45 51 1110.1LIF, ADRB1, CCK, DRD1, NPY
46nitric oxide45 24 1110.1MYCN, LIF, ADRB1, DRD1, NPY
47calcium45 51 24 1110.7EWSR1, LIF, ADRB1, CCK, DRD1, NPY
48retinoic acid45 248.6EWSR1, MYCN, LIF, ADRB1, CCK, NPY
49dopamine45 29 24 1110.6NPY, DRD1, CCK, ADRB1, LIF, MYCN
50tyrosine457.2EWSR1, MYCN, LIF, ADRB1, CCK, DRD1

GO Terms for genes affiliated with Neuroepithelioma

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16Gene Ontology
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Biological processes related to Neuroepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation of adenylate cyclase activityGO:0071909.7DRD1, ADRB1
2behavioral fear responseGO:0016629.6DRD1, CCK
3positive regulation of cAMP biosynthetic processGO:0308199.6DRD1, ADRB1
4memoryGO:0076139.3DRD1, ADRB1
5G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.3DRD1, NPY
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1CCK, LIF

Molecular functions related to Neuroepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.3NPY, CCK
2dopamine bindingGO:0352409.3DRD1, ADRB1

Products for genes affiliated with Neuroepithelioma

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Sources for Neuroepithelioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
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37MGI
40NCIt
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44NINDS
45Novoseek
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48OMIM via Orphanet
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59SNOMED-CT via Orphanet
62UMLS
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