MCID: NRP002
MIFTS: 46

Neuroepithelioma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Neuroepithelioma

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Wikipedia:64 Neuroblastoma (NB) is the most common extracranial solid cancer in childhood and the most common cancer... more...

MalaCards based summary: Neuroepithelioma, also known as neuroectodermal tumors, is related to peripheral primitive neuroectodermal tumor and neuroblastoma. An important gene associated with Neuroepithelioma is EWSR1 (EWS RNA-binding protein 1), and among its related pathways are Transcription CREB pathway and Monoamine GPCRs. The compounds noradrenaline and phenylpropanolamine have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland, bone and brain, and related mouse phenotypes are endocrine/exocrine gland and normal.

Description from OMIM:46 612219

Aliases & Classifications for Neuroepithelioma

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Sources:
42NIH Rare Diseases, 46OMIM, 44Novoseek, 61UMLS
See all sources

Neuroepithelioma, Aliases & Descriptions:

Name: Neuroepithelioma 42 46 44
 
Neuroectodermal Tumors 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Related Diseases for Neuroepithelioma

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Diseases related to Neuroepithelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 46)
idRelated DiseaseScoreTop Affiliating Genes
1peripheral primitive neuroectodermal tumor30.7MYCN, EWSR1
2neuroblastoma10.5
3cerebral primitive neuroectodermal tumor10.5EWSR1
4neuroectodermal tumor10.4
5sarcoma10.4
6bone peripheral neuroepithelioma10.2
7embryonal rhabdomyosarcoma10.2EWSR1, MYCN
8soft tissue peripheral neuroepithelioma10.1
9neuronitis10.1
10ganglioneuroblastoma10.1NPY, MYCN
11thyroid medullary carcinoma10.1MYCN, CCK
12psychotic disorder10.1DRD1, CCK
13bulimia nervosa10.1NPY, CCK
14autonomic neuropathy10.1NPY, CCK
15ganglioneuroma10.1NPY, MYCN
16eating disorder10.1NPY, CCK
17anxiety disorder10.1CCK, NPY
18respiratory failure10.1NPY, CCK
19prader-willi syndrome10.1NPY, CCK
20anorexia nervosa10.1NPY, CCK
21alcohol dependence10.1DRD1, NPY
22mood disorder10.0DRD1, NPY
23congestive heart failure10.0NPY, ADRB1
24hepatitis10.0
25hepatitis c10.0
26olfactory neuroblastoma10.0
27coloboma10.0
28microphthalmia10.0
29meningioma10.0
30retinoblastoma10.0
31rhabdomyosarcoma10.0
32transitional cell carcinoma10.0
33cerebellar degeneration10.0
34paraneoplastic cerebellar degeneration10.0
35hepatitis c virus10.0
36teratoma10.0
37essential hypertension10.0NPY, DRD1, ADRB1
38neuroendocrine tumor9.9MYCN, CCK, NPY
39embryonal cancer9.9LIF, MYCN
40huntington's disease9.9DRD1, NPY
41schizophrenia9.9CCK, DRD1, NPY
42congenital heart disease9.8LIF, ADRB1, NPY
43pheochromocytoma9.8MYCN, LIF, NPY
44obesity9.6LIF, ADRB1, CCK, NPY
45malignant glioma9.6MYCN, LIF, ADRB1, NPY
46alzheimer's disease9.6LIF, CCK, DRD1, NPY

Graphical network of the top 20 diseases related to Neuroepithelioma:



Diseases related to neuroepithelioma

Symptoms for Neuroepithelioma

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Clinical features from OMIM:

612219

Drugs & Therapeutics for Neuroepithelioma

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Drug clinical trials:

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Search NIH Clinical Center for Neuroepithelioma

Genetic Tests for Neuroepithelioma

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Anatomical Context for Neuroepithelioma

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MalaCards organs/tissues related to Neuroepithelioma:

32
Adrenal gland, Bone, Brain, Cerebellum, Spinal cord, Colon, Kidney, Uterus, Cervix, Pineal

Animal Models for Neuroepithelioma or affiliated genes

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MGI Mouse Phenotypes related to Neuroepithelioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.2EWSR1, LIF, ADRB1, CCK
2MP:00028738.2EWSR1, MYCN, DRD1, NPY
3MP:00053818.1NPY, DRD1, LIF, MYCN
4MP:00053698.1EWSR1, MYCN, LIF, ADRB1, DRD1
5MP:00053758.0NPY, DRD1, ADRB1, LIF, EWSR1
6MP:00107687.9DRD1, ADRB1, LIF, MYCN, EWSR1
7MP:00053907.9EWSR1, MYCN, LIF, ADRB1, NPY
8MP:00036317.5MYCN, LIF, CCK, DRD1, NPY
9MP:00053787.4EWSR1, MYCN, LIF, ADRB1, DRD1, NPY
10MP:00053767.2MYCN, LIF, ADRB1, CCK, DRD1, NPY

Publications for Neuroepithelioma

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Articles related to Neuroepithelioma:

(show top 50)    (show all 121)
idTitleAuthorsYear
1
Solitary epidural brain metastasis of a peripheral neuroepithelioma (a primitive neuroectodermal tumor): a case report. (22470583)
2008
2
Polyphenotypic peripheral neuroepithelioma occuring in the foot: a case report. (17474251)
2007
3
Paraneoplastic cerebellar degeneration in olfactory neuroepithelioma. (16361612)
2006
4
Olfactory neuroepithelioma: an immunohistochemical and ultrastructural study. (17080716)
2006
5
Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. (12873973)
2003
6
Antisense to glucosylceramide synthase in human neuroepithelioma affects cell growth but not apoptosis. (12032678)
2002
7
Peripheral neuroepithelioma with ganglion cells: report of two cases and review of the literature. (9841705)
1999
8
An autopsy case of peripheral neuroepithelioma in posterior mediastinum with p53 point mutation. (9617873)
1998
9
Collision tumor: a peripheral neuroepithelioma and a transitional-cell carcinoma occurring simultaneously in the renal pelvis. (9869830)
1997
10
Retinoic acid-induced regulation of neuropeptide Y receptor expression and function in the neuroepithelioma line SK-N-MC. (9165460)
1997
11
Paracrine mediation of calcium signaling in human SK-N-MCIXC neuroepithelioma cells. (8760029)
1996
12
Intra- and intercellular calcium signaling in human neuroepithelioma cells. (8906559)
1996
13
Immunohistochemical profile of monoclonal antibody O13: antibody that recognizes glycoprotein p30/32MIC2 and is useful in diagnosing Ewing's sarcoma and peripheral neuroepithelioma. (7513503)
1994
14
Second messenger activators regulate CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC. (7514375)
1994
15
Neuroepithelioma (primitive neuroectodermal tumor) and Ewing's sarcoma. At least a partial consensus. (8204005)
1994
16
Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma. (8439553)
1993
17
Regulation of CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC in response to second messenger activators. (7694875)
1993
18
Peripheral neuroepithelioma of the soft tissues. A retrospective analysis of fifteen pediatric patients. (8328643)
1993
19
Use of HBA 71 and anti-beta 2-microglobulin to distinguish peripheral neuroepithelioma from neuroblastoma. (8375858)
1993
20
Fine needle aspiration of peripheral neuroepithelioma of soft tissues. (1542998)
1992
21
Unicolor and bicolor in situ hybridization in the diagnosis of peripheral neuroepithelioma and related tumors. (1384659)
1992
22
Expression of p53 in human neuroblastoma- and neuroepithelioma-derived cell lines. (1741160)
1992
23
Cyclic AMP potentiates receptor-stimulated phosphoinositide hydrolysis in human neuroepithelioma cells. (1355263)
1992
24
Peripheral neuroepithelioma: a light microscopic, immunocytochemical, and ultrastructural study. (1371873)
1992
25
Case report 682. Neuroepithelioma of soft tissues of the knee. (1896883)
1991
26
Adult peripheral neuroepithelioma in Meckel's cave. (1997905)
1991
27
Identification of multiple phosphoinositide-linked receptors on human SK-N-MC neuroepithelioma cells. (1681032)
1991
28
Characterization and regulation of beta 1-adrenergic receptors in a human neuroepithelioma cell line. (1671088)
1991
29
The cholecystokinin gene is abundantly co-expressed with gastrin-releasing peptide, enkephalin and neuropeptide Y genes in a clonal human neuroepithelioma cell line. (2384178)
1990
30
Nerve growth factor-induced differentiation of human neuroblastoma and neuroepithelioma cell lines. (1964795)
1990
31
Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line. (2205380)
1990
32
A case of malignant neuroepithelioma in the retroperitoneum]. (2407879)
1990
33
Neuropeptide Y binding and inhibition of cAMP accumulation in human neuroepithelioma cells. (2159234)
1990
34
Peripheral neuroectodermal tumour (neuroepithelioma) of the thoracopulmonary region: light and electron microscopic cytology. (2102358)
1990
35
Spontaneous olfactory neuroepithelioma in a domestic medaka (Oryzias latipes). (2720659)
1989
36
Expression of the cholecystokinin gene by cultured human primitive neuroepithelioma cell lines. (2753982)
1989
37
Primary peripheral neuroepithelioma of the orbit with intracranial extension. (3191459)
1988
38
Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepithelioma. (3390826)
1988
39
Treatment of peripheral neuroepithelioma in children and young adults. (3316513)
1987
40
Neuroepithelioma (neuroblastoma) arising in an adult. A case report. (4044631)
1985
41
Extraskeletal Ewing's sarcoma (peripheral neuroepithelioma). (4089998)
1985
42
Peripheral neuroepithelioma in childhood. (6498781)
1984
43
Chromosome translocation in peripheral neuroepithelioma. (6749231)
1984
44
Olfactory neuroepithelioma in a cynomolgus monkey (Macaca fascicularis). (1123841)
1975
45
Malignant neuroepithelioma in childhood. A report of three cases. (5372849)
1969
46
Tumors in amphibians. I. Histology of a neuroepithelioma in Siredon mexicanum. (4163837)
1967
47
Olfactory neuroepithelioma. Report of a case (13853935)
1959
48
Neuroepithelioma; its place in the histogenetic classification of primary neuroectodermal brain tumors. (13097186)
1953
49
Intraorbital melanosis and intracranial neuroepithelioma of the optic nerve. (20990384)
1946
50
Neuroepithelioma of the Cerebellum. (19969839)
1929

Variations for Neuroepithelioma

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Expression for genes affiliated with Neuroepithelioma

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Expression patterns in normal tissues for genes affiliated with Neuroepithelioma

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Pathways for genes affiliated with Neuroepithelioma

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Compounds for genes affiliated with Neuroepithelioma

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Compounds related to Neuroepithelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1noradrenaline2910.0DRD1, ADRB1
2phenylpropanolamine44 25 1212.0ADRB1, DRD1
3raclopride44 2910.9CCK, DRD1
4asenapine29 1210.9ADRB1, DRD1
5[met]enkephalin449.8NPY, CCK
6cyclo(his-pro)449.7CCK, NPY
7octadecaneuropeptide449.7CCK, NPY
8sulpiride44 29 1211.7NPY, DRD1
9bethanechol44 29 1211.7CCK, NPY
10enterostatin449.7CCK, NPY
11npff449.7CCK, NPY
12alpha msh449.7CCK, NPY
13incretin449.7NPY, CCK
14prazosin44 29 50 1212.6NPY, ADRB1
15muscimol44 60 2911.6NPY, DRD1
16fenfluramine44 29 1211.6CCK, NPY
17nicardipine44 29 1211.6CCK, DRD1
18oxyntomodulin44 6010.6NPY, CCK
19orlistat44 60 1211.6NPY, CCK
20phosphoramidon44 1210.4CCK, NPY
21methamphetamine44 50 1211.4NPY, DRD1
22amphetamine44 50 1211.3NPY, DRD1, CCK
23atropine44 29 1211.3NPY, DRD1, CCK
24opiate449.3CCK, DRD1, NPY
25cocaine44 1210.3NPY, DRD1, CCK
26naloxone44 29 50 1212.2DRD1, CCK
27gaba449.2NPY, DRD1, CCK
28nmda44 2910.1NPY, DRD1, ADRB1
29phenylephrine44 29 25 1212.0LIF, ADRB1, NPY
30isoproterenol44 1210.0NPY, ADRB1, LIF
31catecholamine448.9MYCN, ADRB1, DRD1, NPY
32glutamine448.9NPY, CCK, EWSR1
33adenylate448.9NPY, DRD1, CCK, ADRB1
34acth448.8LIF, CCK, NPY
35glutamate448.8ADRB1, CCK, DRD1, NPY
36genistein44 29 60 3 25 1213.7MYCN, LIF, DRD1
37paraffin448.5EWSR1, MYCN, LIF, NPY
38carbachol44 29 1210.5NPY, DRD1, CCK, LIF
39acetylcholine44 50 29 25 1212.5LIF, CCK, DRD1, NPY
40glucose448.3LIF, ADRB1, CCK, NPY
41serine448.3EWSR1, MYCN, LIF, ADRB1, DRD1
42cyclic amp44 259.2EWSR1, LIF, ADRB1, DRD1, NPY
43arginine448.2NPY, CCK, ADRB1, LIF, EWSR1
44norepinephrine44 25 1210.1LIF, ADRB1, CCK, DRD1, NPY
45forskolin44 50 1210.1LIF, ADRB1, CCK, DRD1, NPY
46nitric oxide44 25 1210.1MYCN, LIF, ADRB1, DRD1, NPY
47calcium44 50 25 1210.7EWSR1, LIF, ADRB1, CCK, DRD1, NPY
48retinoic acid44 258.6EWSR1, MYCN, LIF, ADRB1, CCK, NPY
49dopamine44 29 25 1210.6NPY, DRD1, CCK, ADRB1, LIF, MYCN
50tyrosine447.2EWSR1, MYCN, LIF, ADRB1, CCK, DRD1

GO Terms for genes affiliated with Neuroepithelioma

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Biological processes related to Neuroepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1activation of adenylate cyclase activityGO:0071909.7DRD1, ADRB1
2behavioral fear responseGO:0016629.6DRD1, CCK
3positive regulation of cAMP biosynthetic processGO:0308199.6DRD1, ADRB1
4memoryGO:0076139.3DRD1, ADRB1
5G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.3DRD1, NPY
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1CCK, LIF

Molecular functions related to Neuroepithelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuropeptide hormone activityGO:0051849.3NPY, CCK
2dopamine bindingGO:0352409.3DRD1, ADRB1

Products for genes affiliated with Neuroepithelioma

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Sources for Neuroepithelioma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet