Neuroepithelioma malady

Wikipedia: Neuroblastoma (N.B.) is the most common extracranial solid cancer in childhood and the most common...⁴⁴ more...

MalaCards: Neuroepithelioma, also known as neuroectodermal tumors, is related to supratentorial primitive neuroectodermal tumor and medulloblastoma. An important gene associated with Neuroepithelioma is NET1 (neuroepithelial cell transforming 1), and among its related pathways are Apoptosis and survival Role of CDK5 in neuronal death and survival and Signal transduction_PTEN pathway. The compounds glucose and carbachol have been mentioned in the context of this disorder. Affiliated tissues include adrenal gland and cervix, and related mouse phenotypes are hematopoietic system and liver/biliary system.

OMIM: 612219

neuroepithelioma 7 30 33 32 neuroectodermal tumors 43

Diseases related to neuroepithelioma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 429)

id	Related Disease	Score	Top Affiliating Genes
1	supratentorial primitive neuroectodermal tumor	34.7	MYC, MYCN, CD99, DDC
2	medulloblastoma	32.0	NCAM1, MYC, MYCN, LIF, UGCG, ENO2
3	ewing's family of tumors	30.9	NCAM1, MYC, MYCN, GRP, EWSR1, NGF
4	extraosseous ewing's sarcoma	30.8	CD99, EWSR1
5	rhabdoid tumors	30.7	NCAM1, MYC, MYCN, ENO2, IGF1R
6	cerebral primitive neuroectodermal tumor	30.6	NCAM1, KITLG, MYC, MYCN, CD99, FLI1
7	lymphoblastic lymphoma	29.3	CD99, FLI1, ENO2
8	peripheral primitive neuroectodermal tumor	28.4	KITLG, FLI1, MAPK1, CASP3, EWSR1
9	vaginitis	27.2	LIF, LEP, CD99, CASP3, EDN1, EGFR
10	sarcoma	27.0	NCAM1, RET, KITLG, MYC, MYCN, LEP
11	synovial sarcoma	26.5	MYCN, CD99, FLI1, MAPK1, IGF1R, IGFBP2
12	duodenitis	26.3	KITLG, MYCN, LEP, B2M, GRP, ENO2
13	soft tissue sarcoma	25.7	KITLG, MYC, LEP, B2M, MAPK10, IGF1R
14	wilms tumor	25.5	NCAM1, RET, MYC, MYCN, FLI1, ENO2
15	malignant glioma	25.3	KITLG, MYC, GRP, MAPK1, IGF1R, IGF1
16	neuroectodermal tumors	24.9	NCAM1, KITLG, MYC, MYCN, CD99, FLI1
17	retinoblastoma	22.9	NCAM1, KITLG, MYC, MYCN, ENO2, MAPK10
18	cerebritis	22.5	NCAM1, KITLG, LPAR3, MYC, MYCN, LIF
19	astrocytoma	22.5	NCAM1, RET, LPAR3, MYC, GRP, ENO2
20	hypoxia	20.1	RET, KITLG, MYC, MYCN, LIF, LEP
21	pancreatitis	18.2	NCAM1, RET, KITLG, PCSK2, MYC, LIF
22	prostatitis	18.2	NCAM1, RET, KITLG, LPAR3, MYC, LIF
23	neuroblastoma	17.9	NCAM1, RET, KITLG, PCSK2, MYC, MYCN
24	neuronitis	17.0	NCAM1, RET, KITLG, PCSK2, LPAR3, MYC
25	carcinoma	16.1	NCAM1, RET, KITLG, PCSK2, LPAR3, MYC
26	bladder sarcoma	13.8	CD99, FLI1
27	central nervous system cancer	13.8	CD99, FLI1, EWSR1
28	esthesioneuroblastoma	13.7	CD99, FLI1, ENO2
29	labyrinthitis	13.7	CHAT, NPY, ADRB1
30	acute mountain sickness	13.6	ENO2, CCK, EDN1
31	desmoplastic small round cell tumor	13.6	CD99, FLI1, ENO2, EWSR1
32	cognitive disease	13.6	CHAT, ENO2, DRD1
33	orbit embryonal rhabdomyosarcoma	13.6	NCAM1, MYCN, EWSR1
34	esophageal atresia	13.6	MYCN, GRP, ENO2, NPY
35	merkel cell carcinoma	13.5	NCAM1, ENO2, MAPK10
36	corticobasal degeneration	13.5	MYC, MAPK1, CASP3
37	insensitivity to pain	13.5	MAPK10, MAPK1, NGF
38	anhidrosis	13.5	MAPK10, MAPK1, NGF
39	hepatorenal syndrome	13.5	EDN1, EDN3, NPY
40	ganglioneuroblastoma	13.5	MYCN, ENO2, NPY
41	nicotine dependence	13.4	NCAM1, CHAT, DRD1, DDC
42	status epilepticus	13.4	LIF, ENO2, CASP3, NPY
43	angiosarcoma	13.4	KITLG, MYC, CHAT, FLI1
44	alveolar rhabdomyosarcoma	13.4	MYCN, ENO2, IGF1R
45	cerebral artery occlusion	13.3	MAPK1, NOS1, NGF, EDN1
46	diabetic polyneuropathy	13.3	LIF, NOS1, NGF
47	progressive supranuclear palsy	13.3	MYC, CHAT, MAPK1, CASP3, NGF
48	familial medullary thyroid carcinoma	13.3	RET, GRP, ENO2
49	drug dependence	13.2	NCAM1, DRD1, PPYR1, NOS1, NPY
50	vitiligo	13.2	KITLG, CASP3, DDC, EDN1, NPY

Clinical features from OMIM: 612219

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to neuroepithelioma:

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MGI Mouse Phenotypes related to neuroepithelioma:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.1	FLI1, MYCN, EWSR1
2	liver/biliary system phenotype	MP:0005370	9.6	MYCN, LIF, FLI1, CREM, EGFR
3	respiratory system phenotype	MP:0005388	9.6	RET, MYCN, LIF, CREM, NOS1
4	endocrine/exocrine gland phenotype	MP:0005379	9.1	PPYR1, EWSR1, PCSK2, RET, NRG1
5	immune system phenotype	MP:0005387	9.0	EGFR, IGFBP2, DRD1, EWSR1, IGF1R, FLI1
6	renal/urinary system phenotype	MP:0005367	8.9	EWSR1, IGFBP2, MYCN, CASP3, DDC, RET
7	normal phenotype	MP:0002873	8.4	RET, NOS1, NPY, DRD1, PPYR1, IGF1
8	limbs/digits/tail phenotype	MP:0005371	8.4	RET, KITLG, IGF1R, LEP, EGFR, MYCN
9	pigmentation phenotype	MP:0001186	8.3	EDN3, EGFR, CASP3, LEP, MYC, KITLG
10	embryogenesis phenotype	MP:0005380	7.9	MYC, UGCG, EGFR, NRG1, MYCN, FLI1
11	adipose tissue phenotype	MP:0005375	7.7	PPYR1, LIF, LEP, IGF1R, IGF1, ADRB1
12	skeleton phenotype	MP:0005390	7.6	ADRB1, EGFR, MYCN, NOS1, CASP3, MYC
13	integument phenotype	MP:0010771	7.5	PCSK2, KITLG, IGF1R, EWSR1, DRD1, PPYR1
14	vision/eye phenotype	MP:0005391	7.4	LEP, MYCN, KITLG, NCAM1, CASP3, DRD1
15	tumorigenesis	MP:0002006	7.3	IGF1R, EGFR, EWSR1, IGF1, LEP, FLI1
16	reproductive system phenotype	MP:0005389	7.3	B2M, CASP3, EWSR1, PPYR1, NRG1, CHAT
17	digestive/alimentary phenotype	MP:0005381	7.0	RET, KITLG, MYC, MYCN, EGFR, LIF
18	behavior/neurological phenotype	MP:0005386	6.8	NGF, LIF, CHAT, NPY, NOS1, LEP
19	nervous system phenotype	MP:0003631	6.8	DDC, NRG1, CREM, NOS1, NGF, EDN1
20	growth/size phenotype	MP:0005378	6.5	CHAT, IGF1R, CASP3, EWSR1, DRD1, NGF
21	mortality/aging	MP:0010768	6.1	LEP, NCAM1, MYCN, KITLG, PCSK2, NGF
22	muscle phenotype	MP:0005369	5.9	LIF, LEP, CHAT, FLI1, MAPK1, IGF1R
23	cardiovascular system phenotype	MP:0005385	4.7	CREM, NOS1, EDN1, EGFR, ADRB1, LEP
24	cellular phenotype	MP:0005384	4.7	FLI1, PCSK2, KITLG, RET, NCAM1, ENO2
25	homeostasis/metabolism phenotype	MP:0005376	4.4	NOS1, EGFR, DRD1, IGF1R, ADRB1, PPYR1

Articles related to neuroepithelioma:

(show all 33)

id	Title	Authors	Year	Affiliating Genes
1	Evidence against a direct effect of leptin on insulin-like growth factor-I (IGF-I), IGFBP-2 and IGF-I receptor expression in human SK-N-MC neuroepithelioma cells. (15932773)	Kiess W.... Kratzsch J.	2005	IGF1R, IGF1, LEP
2	Integration of G protein signals by extracellular signal-regulated protein kinases in SK-N-MC neuroepithelioma cells. (15992362)	Chan A.S.... Wong Y.H.	2005	MAPK1, PPYR1
3	From transcription profile to expression: the signaling repertoire of the SK-N-MC neuroepithelioma cell-line. (15648446)	Bader J.E.... Beck-Sickinger A.G.	2004	RNY5
4	Constitutive activation of the neuregulin-1/erbB signaling pathway promotes the proliferation of a human peripheral neuroepithelioma cell line. (15015657)	Fallon K.B.... Carroll S.L.	2004	EGFR, NRG1
5	Cyclic AMP-mediated upregulation of the expression of neuronal NO synthase in human A673 neuroepithelioma cells results in a decrease in the level of bioactive NO production: analysis of the signaling mechanisms that are involved. (15170357)	Boissel J.P.... Forstermann U.	2004	NOS1, CREM
6	Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells. (12873973)	Di Sano F.... Piacentini M.	2003	UGCG, RTN1, RTN3
7	Signalling pathways involved in the chemotactic activity of CXCL12 in cultured rat cerebellar neurons and CHP100 neuroepithelioma cells. (12576222)	Floridi F.... Limatola C.	2003	MAPK1
8	Caspase inhibition shifts neuroepithelioma cell response to okadaic acid from apoptosis to an apoptotic-like form of death. (12659841)	Romano E.... Spinedi A.	2003	CASP3
9	Regulation of human beta(1)-adrenergic receptors and their mRNA in neuroepithelioma SK-N-MC cells: effects of agonist, forskolin, and protein kinase A. (11705454)	Bahouth S.W.... Lima J.J.	2001	ADRB1
10	Potentiation of okadaic acid-induced ceramide elevation but not apoptosis by inhibition of glucosylceramide synthase in human neuroepithelioma cells. (11274971)	Di Bartolomeo S.... Spinedi A.	2001	UGCG
11	Ceramide accumulation precedes caspase-dependent apoptosis in CHP-100 neuroepithelioma cells exposed to the protein phosphatase inhibitor okadaic acid. (10453072)	Spinedi A.... Piacentini M.	1999	DUSP19
12	Potentiation of G-protein-coupled receptor-induced MAP kinase activation by exogenous EGF receptors in SK-N-MC neuroepithelioma cells. (9790898)	Buist A.... den Hertog J.	1998	MAPK10, EDN1, LPAR3
13	Collision tumor: a peripheral neuroepithelioma and a transitional-cell carcinoma occurring simultaneously in the renal pelvis. (9869830)	Phan S.T.... Weidner N.	1997	CD99
14	Retinoic acid-induced regulation of neuropeptide Y receptor expression and function in the neuroepithelioma line SK-N-MC. (9165460)	Shorter N.A.... Pence J.C.	1997	NPY
15	Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation. (9121763)	van Puijenbroek A.A.... den Hertog J.	1997	RET, MAPK1
16	Paracrine mediation of calcium signaling in human SK-N-MCIXC neuroepithelioma cells. (8760029)	Palmer R.K.... Fisher S.K.	1996	CANT1
17	Isolation of a novel oncogene, NET1, from neuroepithelioma cells by expression cDNA cloning. (8649828)	Chan A.M.-L.... Miki T.	1996	NET1
18	Intra- and intercellular calcium signaling in human neuroepithelioma cells. (8906559)	Palmer R.K.... Fisher S.K.	1996	EDN1
19	Peripheral neuroepithelioma (peripheral primitive neuroectodermal tumor) of the uterine cervix. (9111767)	Sato S.... Sakuma H.	1996	ENO2
20	Second messenger activators regulate CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC. (7514375)	Mania-Farnell B.L.... Davis T.P.	1994	CCK
21	Agonist-specific calcium signaling and phosphoinositide hydrolysis in human SK-N-MCIXC neuroepithelioma cells. (7964729)	Palmer R.K.... Fisher S.K.	1994	EDN1
22	Human FLI-1 localizes to chromosome 11q24 and has an aberrant transcript in neuroepithelioma. (8439553)	Hromas R.... Klemsz M.J.	1993	FLI1
23	Use of HBA 71 and anti-beta 2-microglobulin to distinguish peripheral neuroepithelioma from neuroblastoma. (8375858)	Pappo A.S.... Parham D.M.	1993	B2M
24	Regulation of CCK mRNA in the human neuroepithelioma cell line SK-N-MCIXC in response to second messenger activators. (7694875)	Mania-Farnell B.L.... Davis T.P.	1993	CCK, DYT10
25	Peripheral neuroepithelioma: a light microscopic, immunocytochemical, and ultrastructural study. (1371873)	Cavazzana A.O.... Triche T.J.	1992	B2M
26	Cyclic AMP potentiates receptor-stimulated phosphoino sitide hydrolysis in human neuroepithelioma cells. (1355263)	Fisher S.K.... Landon R.E.	1992	EDN1
27	Characterization and regulation of beta 1-adrenergic receptors in a human neuroepithelioma cell line. (1671088)	Fishman P.H.... Duman R.S.	1991	ADRB1
28	Antisense inhibition of N-myc reduces cell growth but does not affect c-myc expression in the neuroepithelioma cell line CHP100. (2068146)	Rosolen A.... Neckers L.M.	1991	MYC
29	Identification of multiple phosphoinositide-linked receptors on human SK-N-MC neuroepithelioma cells. (1681032)	Fisher S.K.... Landon R.E.	1991	EDN3, EDN1
30	The cholecystokinin gene is abundantly co-expressed with gastrin-releasing peptide, enkephalin and neuropeptide Y genes in a clonal human neuroepithelioma cell line. (2384178)	Verbeeck M.A.... Burbach J.P.	1990	NPY, CCK, GRP
31	Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line. (2205380)	Rosolen A.... Neckers L.M.	1990	MYC
32	Neuropeptide Y binding and inhibition of cAMP accumulation in human neuroepithelioma cells. (2159234)	Lobaugh L.A.... Blackshear P.J.	1990	NPY
33	A case of malignant neuroepithelioma in the retroperitoneum (2407879)	Hara T.... Sugihara T.	1990	ENO2

Genes related to neuroepithelioma according to GeneCards:

(show all 43)

id	Symbol	Description	Score	GeneCards Section Context
1	NET1	neuroepithelial cell transforming 1	11.1	Publications, Aliases & Descriptions
2	EWSR1	Ewing sarcoma breakpoint region 1	11.0
3	CD99	CD99 molecule	11.0	Publications
4	ADRB1	adrenoceptor beta 1	11.0	Publications
5	UGCG	UDP-glucose ceramide glucosyltransferase	11.0	Publications
6	FLI1	Friend leukemia virus integration 1	11.0	Publications, UniProt Related
7	MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	11.0
8	GRP	gastrin-releasing peptide	11.0	Publications
9	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
10	CCK	cholecystokinin	11.0	Publications
11	NPY	neuropeptide Y	11.0	Publications
12	CHAT	choline O-acetyltransferase	11.0
13	DRD1	dopamine receptor D1	11.0
14	PCSK2	proprotein convertase subtilisin/kexin type 2	11.0
15	EDN1	endothelin 1	11.0	Publications
16	DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	11.0
17	LIF	leukemia inhibitory factor	11.0
18	KITLG	KIT ligand	11.0
19	MAPK1	mitogen-activated protein kinase 1	11.0	Publications
20	MAPK10	mitogen-activated protein kinase 10	11.0	Publications
21	NOS1	nitric oxide synthase 1 (neuronal)	11.0	Publications
22	NGF	nerve growth factor (beta polypeptide)	11.0
23	MYC	v-myc myelocytomatosis viral oncogene homolog (avian)	11.0	Publications
24	NCAM1	neural cell adhesion molecule 1	11.0
25	CASP3	caspase 3, apoptosis-related cysteine peptidase	11.0	Publications
26	RNY5	RNA, Ro-associated Y5	11.0	Publications
27	PPYR1	pancreatic polypeptide receptor 1	11.0	Publications
28	RTN3	reticulon 3	11.0	Publications
29	CREM	cAMP responsive element modulator	11.0	Publications
30	CANT1	calcium activated nucleotidase 1	11.0	Publications
31	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0	Publications
32	EDN3	endothelin 3	11.0	Publications
33	LPAR3	lysophosphatidic acid receptor 3	11.0	Publications
34	DUSP19	dual specificity phosphatase 19	11.0	Publications
35	RTN1	reticulon 1	11.0	Publications
36	B2M	beta-2-microglobulin	11.0	Publications
37	IGF1R	insulin-like growth factor 1 receptor	11.0	Publications
38	RET	ret proto-oncogene	11.0	Publications
39	DYT10	dystonia 10	11.0	Publications
40	LEP	leptin	11.0	Publications
41	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
42	NRG1	neuregulin 1	11.0	Publications
43	EGFR	epidermal growth factor receptor	11.0	Publications

Pathways related to neuroepithelioma according to GeneDecks:

(show top 50)    (show all 88)

id	Pathway	Score	Top Affiliating Genes
1	Apoptosis and survival Role of CDK5 in neuronal death and survival10	10.7	NGF
2	Signal transduction_PTEN pathway41	10.5	IGF1R
3	Sympathetic Nerve Pathway (Neuroeffector Junction)34	10.3	ADRB1, CHAT, DDC, NPY
4	Development_EGFR signaling via small GTPases41	10.3	MAPK1, MYC, MAPK10
5	Development_Ligand-independent activation of ESR1 and ESR241	10.1	IGF1, DRD1, ADRB1
6	Development EGFR signaling via small GTPases10	9.8	MAPK10, MYC, MAPK1, EGFR
7	Neuroscience3	9.6	MYCN, ENO2, NOS1, NGF, NCAM1, RET
8	Apoptosis and survival_Role of CDK5 in neuronal death and survival41	9.4	CASP3, NGF, NRG1, MAPK1, MAPK10
9	Development IGF-RI signaling10	9.3	MYC, MAPK1, IGF1R, IGFBP2, IGF1
10	Development_IGF-1 receptor signaling41	9.3	IGFBP2, IGF1, IGF1R, MYC, MAPK1
11	NFAT and Cardiac Hypertrophy36	9.2	EDN1, IGF1, IGF1R, MAPK10, LIF, MAPK1
12	ERK5 Signaling36	9.2	NRG1, KITLG, EGFR, MYC
13	Development Ligand-independent activation of ESR1 and ESR210	9.2	NRG1, DRD1, EGFR, ADRB1, MAPK1
14	Signal transduction PTEN pathway10	9.0	IGF1R, CASP3, EGFR, MAPK1, IGF1
15	Endothelin-1 Signaling Pathway36	9.0	CASP3, EGFR, EDN1, NOS1, IGF1R, MAPK1
16	ErbB signaling pathway20	9.0	EGFR, MAPK10, MAPK1, NRG1, MYC
17	Development ERBB-family signaling10	9.0	EGFR, NRG1, MYC
18	Pathways in cancer20	8.9	CASP3, IGF1R, EGFR, MAPK1, MAPK10, MYC
19	Breast Cancer Regulation by Stathmin136	8.9	NET1, EGFR, NRG1, IGF1R, MAPK10
20	Glioblastoma Multiforme36	8.9	MYC, IGF1, IGF1R, MAPK1, EGFR
21	Signaling Involved in Cardiac Hypertrophy36	8.8	LIF, MAPK10, MAPK1, IGF1R, IGF1, EGFR
22	Ras Pathway36	8.8	MAPK1, NET1, EGFR, IGF1R, NRG1, MAPK10
23	14-3-3 Induced Intracellular Signaling36	8.6	NRG1, IGF1, MAPK1, MAPK10, KITLG, IGF1R
24	Molecular Mechanisms of Cancer36	8.4	CASP3, KITLG, MYC, IGF1R, EGFR, NRG1
25	p53 Mediated Apoptosis36	8.2	CASP3, EGFR, IGF1, IGF1R, KITLG, NRG1
26	Telomerase Components in Cell Signaling36	8.1	KITLG, IGF1, MYC, EGFR, NRG1, IGF1R
27	Activation of PKC through GPCR36	8.1	NET1, EGFR, NRG1, IGF1, IGF1R, KITLG
28	Rap1 Pathway36	8.1	KITLG, NET1, MAPK1, IGF1R, NRG1, EGFR
29	Mitochondrial Apoptosis36	8.1	EGFR, IGF1, CASP3, KITLG, IGF1R, NRG1
30	ILK Signaling36	8.1	MAPK1, IGF1R, KITLG, IGF1, NRG1, MAPK10
31	Tyrosine Kinases / Adaptors3	8.1	NRG1, IGF1R, KITLG, RET, EGFR
32	Pancreatic Adenocarcinoma36	8.1	IGF1R, IGF1, NRG1, EGFR, NET1, KITLG
33	p70S6K Signaling36	8.1	EGFR, NRG1, IGF1, IGF1R, MAPK1, MAPK10
34	Renin-Angiotensin Pathway36	8.1	KITLG, MAPK10, MAPK1, IGF1R, IGF1, NRG1
35	DHA Signaling36	8.0	CASP3, KITLG, IGF1R, IGF1, NRG1, EGFR
36	GPCR Pathway36	8.0	MAPK1, IGF1R, NET1, EGFR, NRG1, IGF1
37	NFAT in Immune Response36	8.0	NRG1, IGF1, MAPK1, MAPK10, KITLG, IGF1R
38	PPAR Pathway36	7.9	EGFR, IGF1R, NRG1, KITLG, IGF1, MAPK1
39	Cellular Apoptosis Pathway36	7.9	IGF1R, NRG1, KITLG, CASP3, EGFR, IGF1
40	Estrogen Pathway36	7.9	MAPK10, KITLG, MAPK1, IGF1R, IGF1, EGFR
41	PAK Pathway36	7.9	EGFR, NRG1, IGF1, IGF1R, LIF, KITLG
42	eIF2 Pathway36	7.9	KITLG, MAPK1, IGF1, NRG1, EGFR, IGF1R
43	GSK3 Signaling36	7.9	EGFR, KITLG, NRG1, IGF1R, IGF1, MAPK1
44	Activation of PKA through GPCR36	7.9	ADRB1, NRG1, EGFR, CREM, IGF1R, IGF1
45	Rho Family GTPases36	7.8	NRG1, IGF1, EGFR, NET1, IGF1R, MAPK1
46	Nanog in Mammalian ESC Pluripotency36	7.8	EGFR, NRG1, IGF1, IGF1R, MAPK1, KITLG
47	Antioxidant Action of Vitamin-C36	7.8	IGF1, NRG1, IGF1R, MAPK10, LIF, KITLG
48	MAPK Signaling36	7.7	MAPK10, MYC, MAPK1, IGF1R, NRG1, IGF1
49	Activation of cAMP-Dependent PKA36	7.7	KITLG, CREM, IGF1R, IGF1, NRG1, EGFR
50	MAPK Family Pathway36	7.7	KITLG, NRG1, IGF1, MAPK1, MAPK10, NET1

Compounds related to neuroepithelioma according to GeneDecks:

(show top 50)    (show all 246)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.2	PPYR1, PCSK2, EDN3
2	carbachol32 9 9	11.8	LPAR3, GRP, MAPK10, CCK, DRD1, EDN3
3	sodium nitroprusside32	9.8	CHAT, DUSP19, NPY, EDN3, CCK
4	rapamycin32 42	10.3	KITLG, MAPK10, IGF1R, DUSP19, EGFR
5	phenylephrine32 9 18 9	12.1	EDN3, NGF, DYT10, LEP, LIF, ADRB1
6	ly29400232	8.6	NRG1, PPYR1, RET, LEP, MAPK1, CASP3
7	gaba32 42	9.4	CCK, ENO2, DDC, NRG1, NOS1, NCAM1
8	histamine32 18	9.4	NOS1, NGF, KITLG, GRP, MAPK10, CCK
9	prostaglandin f2alpha32	8.4	EDN3, NPY, DYT10, IGF1, GRP, IGF1R
10	thapsigargin32 42	9.4	GRP, LPAR3, EDN3, MAPK10, MAPK1, EDN1
11	ibmx32	8.4	IGF1, DYT10, DRD1, IGF1R, CCK, MAPK10
12	gf 109203x32 42	9.3	MAPK1, KITLG, GRP, MAPK10, DYT10, NPY
13	lactate32	8.1	ENO2, MAPK10, GRP, CHAT, MYCN, KITLG
14	cyclosporin a32 42	9.0	NOS1, DUSP19, NGF, MAPK10, B2M, UGCG
15	12-o-tetradecanoylphorbol 13-acetate32	7.9	MAPK1, IGFBP2, NRG1, LIF, NGF, MYC
16	gnrh32	7.8	EDN3, NCAM1, NPY, NRG1, IGF1, IGFBP2
17	indomethacin32 9 9	9.8	MYC, NPY, EDN3, EDN1, LEP, B2M
18	arginine32	7.8	RET, EDN3, EDN1, ADRB1, NGF, NOS1
19	glutamine32	7.8	IGF1, CANT1, IGF1R, NOS1, NGF, NPY
20	herbimycin a32 42	8.8	DYT10, KITLG, MYC, MAPK10, MAPK1, IGF1R
21	pge232	7.7	NRG1, MAPK10, LIF, CCK, IGF1R, EGFR
22	creatinine32	7.7	EDN1, NGF, CANT1, B2M, IGF1, IGF1R
23	norepinephrine32 9 18 9	10.7	ENO2, MAPK10, CCK, CANT1, DUSP19, DRD1
24	dopamine32 9 18 9	10.5	NCAM1, RET, ADRB1, MYCN, LIF, CHAT
25	adenylate32	7.3	NOS1, NGF, EDN3, NPY, ADRB1, CREM
26	doxorubicin32 34 9 9	10.2	GRP, B2M, UGCG, MYCN, MYC, NCAM1
27	nmda32 42	8.1	LEP, CHAT, GRP, ENO2, MAPK10, MAPK1
28	alanine32	7.1	ADRB1, MAPK10, IGF1R, GRP, B2M, DDC
29	actinomycin d32	7.0	EDN1, KITLG, MYC, MYCN, LIF, GRP
30	forskolin32 42 9 9	10.0	MAPK1, CCK, IGF1R, IGFBP2, DYT10, DUSP19
31	acetylcholine32 9 18 9	9.9	NCAM1, LIF, LEP, CHAT, GRP, ENO2
32	glutamate32	6.8	DDC, NRG1, CREM, NOS1, EDN3, ADRB1
33	thymidine32 18	7.8	IGF1R, IGFBP2, IGF1, NRG1, NGF, MAPK10
34	cyclic amp32 18	7.7	PCSK2, ADRB1, NPY, EDN3, LPAR3, LIF
35	dexamethasone32 42 34 9 9	10.7	NCAM1, KITLG, PCSK2, MYC, LIF, LEP
36	cisplatin32 34 9 9	9.7	B2M, UGCG, LEP, LIF, MYCN, MYC
37	estrogen32	6.7	IGF1, IGFBP2, IGF1R, MAPK10, GRP, CHAT
38	paraffin32	6.5	CHAT, B2M, CD99, GRP, ENO2, IGF1R
39	tamoxifen32 34 9 9	9.4	MAPK10, MYC, LEP, UGCG, GRP, IGF1R
40	calcium32 9 18 9	9.3	PPYR1, NRG1, NOS1, NGF, RNY5, EDN1
41	wortmannin32 42	6.8	LEP, NRG1, PPYR1, GRP, MAPK10, MAPK1
42	vegf32	5.7	NCAM1, RET, KITLG, LPAR3, MYC, MYCN
43	genistein32 9 18 9	8.6	KITLG, PPYR1, MYC, MYCN, LIF, B2M
44	pd 98,05932	5.5	CHAT, ENO2, MAPK10, MAPK1, IGF1R, IGF1
45	testosterone32 9 18 9	8.3	NPY, EGFR, EDN3, NGF, NOS1, NRG1
46	cycloheximide32	4.8	EDN1, GRP, MAPK10, NGF, NOS1, NRG1
47	phosphatidylinositol32	4.3	EGFR, LIF, MYC, KITLG, RET, NCAM1
48	retinoic acid32 42 18	6.2	GRP, B2M, UGCG, CHAT, LIF, MYCN
49	tyrosine32	3.5	NCAM1, RET, KITLG, PCSK2, LPAR3, MYC
50	serine32	2.9	NCAM1, RET, KITLG, PCSK2, LPAR3, MYC

Cellular components related to neuroepithelioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:030424	9.8	DRD1, CCK, CHAT, MYC, DDC
2	extracellular region	GO:005576	6.4	NCAM1, NPY, KITLG, LEP, B2M, GRP
3	extracellular space	GO:005615	5.7	B2M, LIF, PCSK2, KITLG, GRP, CCK

Biological processes related to neuroepithelioma according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	rhythmic excitation	GO:043179	10.3	EDN1, CHAT
2	memory	GO:007613	10.2	ADRB1, NGF, DRD1, CHAT
3	negative regulation of hormone secretion	GO:046888	10.2	EDN3, LIF, EDN1
4	elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway	GO:051482	10.1	LPAR3, EDN1, DRD1
5	blood circulation	GO:008015	10.0	NPY, EDN3, FLI1, PPYR1
6	release of cytochrome c from mitochondria	GO:001836	9.9	CASP3, CCK, MYC
7	eating behavior	GO:042755	9.8	DRD1, CCK, LEP
8	positive regulation of MAP kinase activity	GO:043406	9.7	KITLG, EDN1, EDN3, EGFR
9	neural crest cell migration	GO:001755	9.7	EDN3, KITLG, RET
10	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	KITLG, LIF, CCK, IGF1
11	positive regulation of mitosis	GO:045840	9.5	EDN3, IGF1, EDN1
12	response to drug	GO:042493	9.3	ENO2, NGF, MYC, CHAT, B2M, EDN1
13	positive regulation of cell migration	GO:030335	9.1	EDN1, RET, IGF1R, EGFR, DRD1
14	positive regulation of DNA replication	GO:045740	9.1	EGFR, IGF1, IGF1R, KITLG
15	positive regulation of Ras protein signal transduction	GO:046579	9.1	IGF1, KITLG, NRG1
16	bone mineralization involved in bone maturation	GO:035630	9.0	LEP, IGF1
17	positive regulation of MAPK cascade	GO:043410	8.9	DUSP19, LEP, LPAR3, LIF, IGF1
18	MAPK cascade	GO:000165	8.7	NRG1, EGFR, MYC, RET, MAPK1
19	positive regulation of cell proliferation	GO:008284	7.7	LIF, LEP, CCK, IGF1R, IGF1, NGF
20	signal transduction	GO:007165	6.8	EDN3, MAPK10, MAPK1, CCK, IGF1R, IGFBP2

Molecular functions related to neuroepithelioma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuropeptide hormone activity	GO:005184	9.8	NPY, GRP, CCK
2	hormone activity	GO:005179	8.7	LEP, CCK, IGF1, EDN1, EDN3
3	growth factor activity	GO:008083	8.0	NGF, NRG1, IGF1, LEP, LIF, KITLG
4	protein binding	GO:005515	4.9	NRG1, CREM, NOS1, EGFR, RTN1, ADRB1