Neurofibroma malady

NIH Rare Diseases: A neurofibroma is a non-cancerous (benign) tumor that develops from the cells and tissues that cover nerves. Some people who develop neurofibromas have a genetic condition known as neurofibromatosis (NF). There are different types of NF, but type 1 is the most common.³⁰

MalaCards: Neurofibroma is related to plexiform neurofibroma and neurofibromatosis. An important gene associated with Neurofibroma is NF1 (neurofibromin 1), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Akt Signaling. The compounds threonine and glucose have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and b cells, and related mouse phenotypes are growth/size and endocrine/exocrine gland.

Wikipedia: A neurofibroma is a benign nerve sheath tumor in the peripheral nervous system. Usually found in...⁴⁴ more...

Aliases & Descriptions:

neurofibroma 6 30 32 43

Diseases related to neurofibroma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 582)

id	Related Disease	Score	Top Affiliating Genes
1	plexiform neurofibroma	34.4	MMP13, TP73, NF1, PDGFRA
2	neurofibromatosis	32.5	KIT, KITLG, RASA2, S100B, MSH6, MMP13
3	atypical neurofibroma	31.7	CD34, NF1, PDPN
4	malignant peripheral nerve sheath tumor	30.2	KIT, S100A1, S100B, CDKN2A, CD34, MMP13
5	neurofibrosarcoma	28.6	TP73, NF1, NF2
6	neuroma	28.1	S100B, B2M, CD34, ANK3, MAPK10, SST
7	cellular schwannoma	28.0	S100A1, S100B, NF1, NF2, DSP
8	ganglioneuroblastoma	27.9	S100B, MBP, DLK1, SST
9	ganglioglioma	27.7	S100B, APOD, CALB2, NES, HGF
10	microphthalmia	27.1	KIT, S100B, MLANA, MITF, MAPK10, NF2
11	acoustic neuroma	26.8	B2M, SST, NF2, TGFB1
12	gastrointestinal stromal tumor	23.7	KIT, KITLG, VEGFA, VCAN, S100A1, S100B
13	meningioma	20.4	VEGFA, VCAN, S100A1, S100B, B2M, CDKN2A
14	astrocytoma	19.0	KIT, VEGFA, BMP6, S100A1, S100B, MSH6
15	neuroblastoma	17.6	KIT, KITLG, VEGFA, BMP6, CLDN5, S100B
16	melanoma	15.6	KIT, KITLG, VEGFA, VCAN, BMP6, S100A1
17	langerhans-cell histiocytosis	13.8	S100A1, S100B, F13A1
18	neurilemmoma	13.8	CD34, NF1, NF2
19	carney triad	13.8	KIT, PDGFRA, PDPN
20	ossifying fibromyxoid tumor	13.8	S100A1, S100B, MBP
21	rosai-dorfman disease	13.8	S100A1, S100B, PDGFRA
22	fibrous histiocytoma	13.7	S100B, CD34, MITF, F13A1
23	gastrointestinal stromal tumor, somatic	13.7	KIT, PDGFRA
24	lentigo maligna melanoma	13.7	S100B, MLANA, MITF
25	kidney clear cell sarcoma	13.7	KIT, S100B, MITF
26	sm-ahnmd	13.7	KIT, KITLG, PDGFRA
27	chronic myelomonocytic leukemia	13.7	KIT, KITLG, NF1, PDGFRA
28	indolent systemic mastocytosis	13.7	KIT, KITLG
29	chondroma	13.7	KIT, S100A1, GLI1, PDGFRA
30	endometrial stromal sarcoma	13.7	KIT, S100B, CD34, PDGFRA
31	blue rubber bleb nevus syndrome	13.7	S100B, MLANA, MITF, NF1
32	cutaneous fibrous histiocytoma	13.7	KITLG, S100A1, S100B, CD34, F13A1
33	piebaldism	13.7	KIT, KITLG, MITF, PDGFRA
34	sarcomatoid mesothelioma	13.7	S100A1, CALB2, PDPN
35	cafe-au-lait spots	13.7	KITLG, MSH6, NF1
36	malignant mixed mullerian tumor	13.7	KIT, S100A1, S100B
37	ossifying fibroma	13.7	S100A1, CD34, F13A1, CALB2
38	myoepithelioma	13.6	KITLG, S100A1, S100B
39	anaplastic ependymoma	13.6	S100B, PTEN, NF2
40	epithelioid sarcoma	13.6	CD34, CALB2, KRT8
41	glomus tumor	13.6	S100A1, S100B, CD34
42	pigmentation disease	13.6	KIT, MITF, TYR
43	fibrosarcoma of bone	13.6	KIT, CDKN2A, PDGFRA
44	amelanotic melanoma	13.6	S100A1, S100B, TYR
45	mast-cell leukemia	13.6	KIT, KITLG, ISG20
46	polymorphous low-grade adenocarcinoma	13.6	KIT, S100A1, S100B, MYH11
47	parachordoma	13.6	S100B, KRT8, MYH11
48	adenoameloblastoma	13.6	CALB2, GLI1, PDPN, KRT8
49	renal oncocytoma	13.6	KIT, KITLG, S100A1, KRT8
50	myelodysplastic syndrome	13.5	KIT, KITLG, CD34, DLK1, NF1, PDGFRA

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to neurofibroma:

²²

MGI Mouse Phenotypes related to neurofibroma:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	INF	CNP, NF1, NF2, PDGFRA, PDPN, KRT8
2	endocrine/exocrine gland phenotype	MP:0005379	9.5	TYR, NF2, NF1, GHR, IFNG, MITF
3	hearing/vestibular/ear phenotype	MP:0005377	9.1	NF2, NF1, TP73, MBP, APOD, MITF
4	liver/biliary system phenotype	MP:0005370	8.6	EGFR, NF2, NF1, GHR, IFNG, MET
5	pigmentation phenotype	MP:0001186	8.4	TYR, EGFR, PDGFRA, NF1, PTEN, MITF
6	renal/urinary system phenotype	MP:0005367	8.3	PDGFRA, EGFR, TYR, GAPDH, MYH11, NF2
7	reproductive system phenotype	MP:0005389	8.2	TGFB1, TYR, KRT8, PDGFRA, NF2, DLK1
8	normal phenotype	MP:0002873	8.1	TYR, PDGFRA, NF1, SST, GLI1, CALB2
9	no phenotypic analysis	MP:0003012	7.9	NEU1, TYR, EGFR, SST, GLI1, MET
10	tumorigenesis	MP:0002006	7.6	TP73, PTEN, NF1, NF2, PDGFRA, EGFR
11	skeleton phenotype	MP:0005390	6.8	PTEN, DLK1, NF2, PDPN, EGFR, TYMP
12	muscle phenotype	MP:0005369	6.5	NF1, PDGFRA, PDPN, EGFR, TGFB1, NEU1
13	vision/eye phenotype	MP:0005391	5.5	PTEN, DLK1, NF1, NF2, EGF, EGFR
14	digestive/alimentary phenotype	MP:0005381	5.4	PTEN, SST, PDGFRA, PDPN, KRT8, EGF
15	cardiovascular system phenotype	MP:0005385	5.1	KRT8, PDPN, PDGFRA, NF1, PTEN, EGFR
16	homeostasis/metabolism phenotype	MP:0005376	4.3	NF2, NF1, SST, DLK1, PTEN, TP73
17	cellular phenotype	MP:0005384	INF	EGFR, PDGFRA, NF1, DLK1, PTEN, TYMP
18	integument phenotype	MP:0010771	INF	PDPN, EGF, EGFR, TYR, , NEU1
19	embryogenesis phenotype	MP:0005380	INF	, TYR, EGFR, KRT8, PDGFRA, NF2
20	immune system phenotype	MP:0005387	INF	NF2, PDGFRA, PDPN, KRT8, EGFR, TYMP
21	behavior/neurological phenotype	MP:0005386	INF	MAPK10, ANK3, MBP, APOD, MITF, S100B
22	hematopoietic system phenotype	MP:0005397	INF	GAPDH, HGF, KRT8, PDGFRA, NF1,
23	mortality/aging	MP:0010768	INF	MYH11, GAPDH, NEU1, NES, F13A1, IFNG
24	craniofacial phenotype	MP:0005382	INF	PDGFRA, NF2, NF1, , TP73, MITF
25	limbs/digits/tail phenotype	MP:0005371	INF	GHR, , NF1, PDGFRA, EGFR, TYR
26	nervous system phenotype	MP:0003631	INF	PTEN, , NF1, NF2, PDGFRA, EGFR
27	respiratory system phenotype	MP:0005388	INF	MYH11, NF2, NF1, , F13A1, CNP

Articles related to neurofibroma:

(show top 50)    (show all 78)

id	Title	Authors	Year	Affiliating Genes
1	Distinguishing neurofibroma from desmoplastic melanom a: the value of the CD34 fingerprint. (21457155)	Yeh I.... McCalmont T.H.	2011	CD34
2	S100B and neurofibromin immunostaining and X-inactiva tion patterns of laser-microdissected cells indicate a multicellular origin of some NF1-associated neurofibromas. (21674567)	Tucker T.... Friedman J.M.	2011	S100B, NF1
3	Perinatal or adult Nf1 inactivation using tamoxifen-i nducible PlpCre each cause neurofibroma formation. (21551249)	Mayes D.A.... Ratner N.	2011	NF1
4	Clinico-pathological and biomolecular findings in Italian patients with multiple cutaneous neurofibromas. (21838856)	Ponti G.... Seidenari S.	2011	NF1
5	A molecular analysis of individuals with neurofibroma tosis type 1 (NF1) and optic pathway gliomas (OPGs), and an assessment of genot ype-phenotype correlations. (21278392)	Sharif S.... Evans D.G.	2011	NF1
6	Podoplanin and CD34 in peripheral nerve sheath tumour s: focus on neurofibromatosis 1-associated atypical neurofibroma. (20821344)	Naber U.... Hagel C.	2011	CD34, PDPN
7	Plexiform neurofibroma genesis: questions of Nf1 gene dose and hyperactive mast cells. (20571392)	Staser K.... Clapp D.W.	2010	NF1
8	Primary localised pleural neurofibroma: expanding the spectrum of spindle cell tumours of the pleura. (20154031)	Langman G.... Papadaki L.	2010	S100B
9	Nestin-positive stem cells in neurofibromas from pati ents with neurofibromatosis type 1-tumorigenic or incidental? (20520523)	Pongpudpunth M.... Mahalingam M.	2010	NES
10	Mucosal Schwann cell 'hamartoma': clinicopathologic study of 26 neural colorectal polyps distinct from neurofibromas and mucosal neuromas. (19065103)	Gibson J.A.... Hornick J.L.	2009	S100B
11	Solitary submucous neurofibroma of the mandible: revi ew of the literature and report of a rare case. (19912641)	Depprich R.... Handschel J.	2009	S100B
12	Tranilast, an anti-allergic drug, down-regulates the growth of cultured neurofibroma cells derived from neurofibromatosis type 1. (19282654)	Yamamoto M.... Yamamoto Y.	2009	TGFB1, KITLG, AREG
13	Identification of growth hormone receptor in plexiform neurofibromas of patients with neurofibromatosis type 1. (18297205)	Cunha K.S.... Fonseca E.C.	2008	GHR
14	Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. (19041782)	Williams J.P.... Ratner N.	2008	EGFR, NF1
15	Germline and somatic NF1 gene mutations in plexiform neurofibromas. (18484666)	Upadhyaya M.... Mautner V.	2008	NF1
16	A gastrointestinal stromal tumor of the stomach morphologically resembling a neurofibroma: demonstration of a novel platelet-derived growth factor receptor alpha exon 18 mutation. (18657298)	Liu T.... Holden J.A.	2008	PDGFRA, KIT
17	Colocalized cellular schwannoma and plexiform neurofibroma in the absence of neurofibromatosis. Case report. (17695403)	Spinner R.J.... Gutmann D.H.	2007	NF1, NF2
18	NF1 plexiform neurofibroma growth rate by volumetric MRI: relationship to age and body weight. (17215493)	Dombi E.... Widemann B.C.	2007	NF1
19	An absence of cutaneous neurofibromas associated with a 3-bp inframe deletion in exon 17 of the NF1 gene (c.2970-2972 delAAT): evidence of a clinically significant NF1 genotype-phenotype correlation. (17160901)	Upadhyaya M.... Messiaen L.	2007	NF1
20	Neurofibromin-deficient Schwann cells have increased lysophosphatidic acid dependent survival and migration-implications for increased neurofibroma formation during pregnancy. (17236191)	Nebesio T.D.... Yang F.C.	2007	NF1
21	Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-beta signaling. (16835260)	Yang F.C.... Clapp D.W.	2006	NF1
22	Somatic loss of wild type NF1 allele in neurofibromas: Comparison of NF1 microdeletion and non-microdeletion patients. (16830335)	De Raedt T.... Legius E.	2006	NF1
23	Bladder neurofibroma: case report and bibliographic review (17190213)	Cabrera Castillo P.M.... De La PeA+a Barthel J.J.	2006	S100B
24	Somatostatinoma: collision with neurofibroma and ultrastructural features. (16874660)	Varikatt W.... Killingsworth M.C.	2006	SST
25	Tight junction proteins and perineurial cells in neurofibromas. (16087703)	Pummi K.P.... Peltonen S.A.	2006	TJP1, CLDN5, CLDN3
26	Pigmented neurofibroma: review of Japanese patients with an analysis of melanogenesis demonstrating coexpression of c-met protooncogene and microphthalmia-associated transcription factor. (16112003)	Motoi T.... Fukayama M.	2005	MITF, NF2, MLANA
27	Biallelic somatic inactivation of the NF1 gene through chromosomal translocations in a sporadic neurofibroma. (15986446)	Storlazzi C.T.... Mertens F.	2005	NF1
28	Apolipoprotein D is down-regulated during malignant transformation of neurofibromas. (16153462)	Hunter S.... Varma V.	2005	APOD
29	Elevated ankyrin G in a plexiform neurofibroma and neuromas associated with pain. (15519868)	Kretschmer T.... Kline D.G.	2004	ANK3
30	Gamma interferon gene transfection efficiently inhibits proliferation of neurofibroma cell lines in vitro. (12692353)	Nakayama J.... Kuroki M.	2003	ISG20
31	NF1 mutations and clinical spectrum in patients with spinal neurofibromas. (12746402)	Kluwe L.... Mautner V.F.	2003	NF1
32	Aberrant CpG island methylation in neurofibromas and neurofibrosarcomas. (12883734)	Gonzalez-Gomez P.... Rey J.A.	2003	TP73
33	Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1. (14514779)	Cunha K.S.... Da Fonseca E.C.	2003	GHR
34	PDGF-BB induces MAP kinase phosphorylation and VEGF expression in neurofibroma-derived cultured cells from patients with neurofibromatosis 1. (12484433)	Kotsuji-Maruyama T.... Otsuka F.	2002	MAPK10
35	Losses in chromosomes 17, 19, and 22q in neurofibromatosis type 1 and sporadic neurofibromas: a comparative genomic hybridization analysis. (12237234)	Koga T.... Kikuchi M.	2002	NF1
36	Gamma interferon directly inhibits the growth of neurofibroma cells in vitro. (12392063)	Nakayama J.... Terao H.	2002	IFNG
37	NF1 deletions in S-100 protein-positive and negative cells of sporadic and neurofibromatosis 1 (NF1)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors. (11438454)	Perry A.... Gutmann D.H.	2001	S100B
38	CDKN2A germline splicing mutation affecting both p16(ink4) and p14(arf) RNA processing in a melanoma/neurofibroma kindred. (11433531)	Petronzelli F.... Genuardi M.	2001	CDKN2A
39	Mitotic recombination effects homozygosity for NF1 germline mutations in neurofibromas. (11431704)	Serra E.... LA!zaro C.	2001	NF1
40	Pigmented (melanotic) neurofibroma: a clinicopathologic and immunohistochemical analysis of 19 lesions from 17 patients. (10716146)	Fetsch J.F.... Miettinen M.	2000	TYR, S100A1
41	Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts. (10900196)	Sherman L.S.... Ratner N.	2000	NF1, RASA2
42	Local injection of recombinant human stem cell factor promotes human skin mast cell survival and neurofibroma cell proliferation in the transplanted neurofibroma in nude mice. (10421057)	Demitsu T.... Yaoita H.	1999	KITLG
43	Deletions of the INK4A gene occur in malignant peripheral nerve sheath tumors but not in neurofibromas. (10595915)	Kourea H.P.... Woodruff J.M.	1999	CDKN2A
44	Quantitative analysis of NF1 and OMGP gene transcripts in sporadic gliomas, sporadic meningiomas and neurofibromatosis type 1-associated plexiform neurofibromas. (10378372)	Peters N.... von Deimling A.	1999	GAPDH, B2M
45	Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation. (10595918)	Nielsen G.P.... Louis D.N.	1999	CDKN2A
46	A novel glial growth inhibitory factor, gliostatin, derived from neurofibroma. (1613506)	Asai K.... Kato T.	1992	TYMP
47	The neurofibromatosis 1 gene transcripts expressed in peripheral nerve and neurofibromas bear the additional exon located in the GAP domain. (1280127)	Teinturier C.... Bernheim A.	1992	NF1
48	Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse. (1432035)	Lee J.K.... Martuza R.L.	1992	B2M
49	The neurofibroma in von Recklinghausen neurofibromatosis has a unicellular origin. (1715669)	Skuse G.R.... Rowley P.T.	1991	NF1
50	Immunohistochemical demonstration of factor XIIIa exp ression in neurofibromas. A practical means of differentiating these tumors fro m neurotized melanocytic nevi and schwannomas. (1690969)	Gray M.H.... Hsu A.	1990	F13A1

Genes related to neurofibroma according to GeneCards:

(show top 50)    (show all 51)

id	Symbol	Description	Score	GeneCards Section Context
1	NF1	neurofibromin 1	11.0	Publications
2	S100B	S100 calcium binding protein B	11.0	Publications
3	CD34	CD34 molecule	11.0	Publications
4	NF2	neurofibromin 2 (merlin)	11.0	Publications
5	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
6	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
7	TP73	tumor protein p73	11.0	Publications
8	CNP	2',3'-cyclic nucleotide 3' phosphodiesterase	11.0	Publications
9	APOD	apolipoprotein D	11.0	Publications
10	GLI1	GLI family zinc finger 1	11.0	Publications
11	S100A1	S100 calcium binding protein A1	11.0	Publications
12	PDPN	podoplanin	11.0	Publications
13	CNTN2	contactin 2 (axonal)	11.0	Publications
14	KITLG	KIT ligand	11.0	Publications
15	B2M	beta-2-microglobulin	11.0	Publications
16	GHR	growth hormone receptor	11.0	Publications
17	F13A1	coagulation factor XIII, A1 polypeptide	11.0	Publications
18	MITF	microphthalmia-associated transcription factor	11.0	Publications
19	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	11.0	Publications
20	ANK3	ankyrin 3, node of Ranvier (ankyrin G)	11.0	Publications
21	MET	met proto-oncogene (hepatocyte growth factor receptor)	11.0	Publications
22	MBP	myelin basic protein	11.0	Publications
23	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
24	CLDN5	claudin 5	11.0	Publications
25	ISG20	interferon stimulated exonuclease gene 20kDa	11.0	Publications
26	DLK1	delta-like 1 homolog (Drosophila)	11.0	Publications
27	CLDN3	claudin 3	11.0	Publications
28	MLANA	melan-A	11.0	Publications
29	AREG	amphiregulin	11.0	Publications
30	VCAN	versican	11.0	Expressions
31	NES	nestin	11.0	Publications
32	RASA2	RAS p21 protein activator 2	11.0	Publications
33	TJP1	tight junction protein 1	11.0	Publications
34	KRT8	keratin 8	11.0	Publications
35	CALB2	calbindin 2	11.0	Publications
36	NEU1	sialidase 1 (lysosomal sialidase)	11.0	Publications
37	TYMP	thymidine phosphorylase	11.0	Publications
38	MYH11	myosin, heavy chain 11, smooth muscle	11.0	Publications
39	MSH6	mutS homolog 6 (E. coli)	11.0	Publications
40	TYR	tyrosinase (oculocutaneous albinism IA)	11.0	Publications
41	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
42	SST	somatostatin	11.0	Publications
43	HGF	hepatocyte growth factor (hepapoietin A; scatter factor)	11.0	Publications
44	PTEN	phosphatase and tensin homolog	11.0	Publications
45	MAPK10	mitogen-activated protein kinase 10	11.0	Publications
46	BMP6	bone morphogenetic protein 6	11.0	Publications
47	IFNG	interferon, gamma	11.0	Publications
48	TGFB1	transforming growth factor, beta 1	11.0	Publications
49	EGFR	epidermal growth factor receptor	11.0	Publications
50	EGF	epidermal growth factor	11.0	Publications

Pathways related to neurofibroma according to GeneDecks:

(show top 50)    (show all 85)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.7	AREG
2	Akt Signaling36	10.0	PDGFRA, MET, HGF, KIT
3	CREB Pathway36	9.9	BMP6, KIT, KITLG, AREG, PDGFRA
4	PPAR Pathway36	9.6	EGFR, KITLG, AREG, PDGFRA, MET, KIT
5	14-3-3 Induced Intracellular Signaling36	9.6	MAPK10, PDGFRA, AREG, TP73, KITLG, TGFB1
6	Glioblastoma Multiforme36	9.5	PTEN, NF1, NF2, PDGFRA, EGFR
7	Telomerase Components in Cell Signaling36	8.9	MET, AREG, BMP6, PDGFRA, EGFR, KITLG
8	Ras Pathway36	8.6	KIT, AREG, MET, MAPK10, EGF, EGFR
9	Breast Cancer Regulation by Stathmin136	8.6	MAPK10, HGF, EGFR, EGF
10	Paxillin Interactions36	8.5	MAPK10, KITLG, EGFR, EGF, PDGFRA, KIT
11	ERK5 Signaling36	8.4	MET, AREG, BMP6, KITLG, EGFR, PDGFRA
12	Rac1 Pathway36	8.4	HGF, KITLG, BMP6, AREG, EGF, TGFB1
13	JNK Pathway36	8.2	TGFB1, EGF, PDGFRA, MAPK10, BMP6, KIT
14	Melanoma20	8.2	PTEN, PDGFRA, EGFR, EGF, MET, MITF
15	PTEN Pathway36	8.1	EGF, HGF, EGFR, PDGFRA, PTEN, MET
16	eIF2 Pathway36	8.1	KITLG, BMP6, KIT, AREG, MET, PDGFRA
17	Renin-Angiotensin Pathway36	7.9	KITLG, KIT, TGFB1, AREG, EGFR, BMP6
18	PAK Pathway36	7.7	KIT, BMP6, KITLG, MYH11, AREG, MET
19	Focal adhesion20	7.7	HGF, EGFR, PDGFRA, EGF, PTEN, MAPK10
20	Apoptotic Pathways in Synovial Fibroblasts36	7.6	EGFR, EGF, HGF, TGFB1, PDGFRA, MET
21	DHA Signaling36	7.6	KITLG, PDGFRA, MET, KIT, BMP6, AREG
22	Nanog in Mammalian ESC Pluripotency36	7.6	HGF, TGFB1, EGFR, KIT, KITLG, BMP6
23	Nuclear Receptor Activation by Vitamin-A36	7.6	KIT, BMP6, AREG, MET, PDGFRA, EGF
24	Activation of PKC through GPCR36	7.5	MET, AREG, KITLG, PDGFRA, EGF, EGFR
25	NF-KappaB (p50-p65) Pathway36	7.5	KITLG, EGF, MET, AREG, HGF, TGFB1
26	eNOS Signaling36	7.5	PDGFRA, KIT, KITLG, BMP6, AREG, EGF
27	Mitochondrial Apoptosis36	7.3	KITLG, HGF, TGFB1, EGFR, BMP6, KIT
28	Cellular Apoptosis Pathway36	7.3	TGFB1, EGFR, CDKN2A, EGF, PDGFRA, MET
29	IP3 Pathway36	7.3	TGFB1, HGF, KITLG, BMP6, EGF, PTEN
30	p53 Mediated Apoptosis36	7.3	PTEN, BMP6, KITLG, KIT, AREG, MET
31	Pancreatic Adenocarcinoma36	7.2	KITLG, KIT, BMP6, MET, EGFR, AREG
32	Intracellular Calcium Signaling36	7.2	KIT, HGF, MET, EGF, TGFB1, BMP6
33	TGF-Beta Pathway36	7.2	BMP6, AREG, MET, MAPK10, EGFR, TGFB1
34	p70S6K Signaling36	7.2	HGF, AREG, MET, MAPK10, PDGFRA, BMP6
35	NFAT in Immune Response36	7.2	KIT, HGF, TGFB1, KITLG, BMP6, AREG
36	Phospholipase-C Pathway36	7.2	HGF, TGFB1, EGFR, EGF, PDGFRA, MET
37	Estrogen Pathway36	7.2	EGFR, PDGFRA, EGF, TGFB1, HGF, AREG
38	GPCR Pathway36	7.2	MET, TGFB1, BMP6, AREG, KIT, MAPK10
39	GSK3 Signaling36	7.1	KITLG, BMP6, KIT, AREG, HGF, TGFB1
40	NF-KappaB Family Pathway36	7.1	HGF, TGFB1, EGFR, EGF, MET, AREG
41	Tec Kinases Signaling36	7.1	PDGFRA, AREG, KITLG, BMP6, MET, MAPK10
42	Cytokine-cytokine receptor interaction20	7.1	IFNG, MET, VEGFA, KITLG, KIT, GHR
43	JAK-STAT Pathway36	7.0	AREG, MET, IFNG, GHR, PDGFRA, HGF
44	MAPK Signaling36	7.0	HGF, BMP6, TGFB1, KIT, KITLG, MET
45	Epithelial Adherens Junctions36	7.0	PTEN, KITLG, MYH11, HGF, TGFB1, EGFR
46	Molecular Mechanisms of Cancer36	7.0	PDGFRA, MET, PTEN, EGFR, AREG, CDKN2A
47	Antioxidant Action of Vitamin-C36	6.9	BMP6, KIT, KITLG, AREG, MET, MYH11
48	Rho Family GTPases36	6.8	TGFB1, HGF, KITLG, BMP6, AREG, MET
49	Pathways in cancer20	6.7	TGFB1, MET, VEGFA, EGFR, EGF, PDGFRA
50	ILK Signaling36	INF	KIT, MAPK10, AREG, MET, KITLG, MYH11

Compounds related to neurofibroma according to GeneDecks:

(show top 50)    (show all 191)

id	Compound	Score	Top Affiliating Genes
1	threonine32	10.1	KRT8, NF2, MSH6
2	glucose32	9.2	KIT, GLI1, GAPDH, NES, TYMP, KRT8
3	agar32	9.1	CNTN2, KITLG, CDKN2A, CD34, MET, KRT8
4	ly29400232	9.1	MYH11, TJP1, VEGFA, TYR, TGFB1
5	agarose32	8.9	KIT, TGFB1, CDKN2A, NEU1, GAPDH, TJP1
6	hyaluronic acid32 18	9.9	BMP6, VCAN, MAPK10, CALB2, PTEN, B2M
7	hematoxylin32	8.9	KIT, S100A1, S100B, CDKN2A, CD34, MLANA
8	heparin32 9 18 9	11.6	MBP, HGF, EGF, KITLG, VCAN, F13A1
9	formaldehyde32 18	9.6	TGFB1, TYR, MAPK10, MBP, B2M, S100B
10	pge232	8.3	EGFR, EGF, SST, MAPK10, MMP13, HGF
11	polysaccharide32	8.0	VCAN, B2M, KITLG, PDPN, TYR, MAPK10
12	bromodeoxyuridine32	8.0	CNTN2, KITLG, BMP6, S100B, KRT8, EGF
13	erlotinib32 34 9 9	10.7	KIT, TYMP, EGFR, EGF, PTEN, AREG
14	lactate32	7.7	KRT8, SST, KIT, KITLG, BMP6, S100B
15	imatinib32 34 9 9	10.7	MAPK10, VEGFA, EGFR, PTEN, TP73, BMP6
16	phosphotyrosine32	7.5	GHR, MAPK10, RASA2, PDGFRA, EGF, EGFR
17	gefitinib32 34 9 9	10.5	HGF, MET, EGFR, EGF, PTEN, AREG
18	nitric oxide32 9 18 9	10.4	MET, NES, PTEN, IFNG, CALB2, TJP1
19	oligonucleotide32	7.3	CNTN2, KIT, VCAN, PDGFRA, KRT8, TGFB1
20	glutamine32	7.3	BMP6, KIT, GAPDH, S100B, B2M, MBP
21	rapamycin32 42	8.1	NF1, KIT, KITLG, VEGFA, MET, MAPK10
22	sb 20358032 42	8.1	HGF, IFNG, EGF, VEGFA, BMP6, MMP13
23	cysteine32	7.0	MMP13, NF1, MBP, MET, S100A1, S100B
24	indomethacin32 9 9	8.8	HGF, MBP, TGFB1, TYMP, EGF, BMP6
25	alanine32	6.7	GHR, MET, CDKN2A, B2M, GAPDH, PTEN
26	phosphatidylinositol32	6.7	TJP1, GHR, NF1, EGF, EGFR, HGF
27	doxorubicin32 34 9 9	9.7	MET, PTEN, SST, KRT8, EGF, EGFR
28	pd 98,05932	6.5	BMP6, HGF, TGFB1, EGFR, KIT, KITLG
29	vegf32	6.5	CNTN2, KIT, KITLG, VCAN, CLDN3, S100B
30	testosterone32 9 18 9	9.5	EGF, SST, GHR, CALB2, APOD, MET
31	tamoxifen32 34 9 9	9.4	GAPDH, TGFB1, EGFR, EGF, KRT8, PTEN
32	estrogen32	6.4	GHR, TJP1, NF1, PDGFRA, KRT8, EGF
33	actinomycin d32	6.4	EGF, TYMP, TGFB1, HGF, GAPDH, KRT8
34	thymidine32 18	7.3	CNTN2, KIT, KITLG, BMP6, S100B, TGFB1
35	5fluorouracil32	6.2	KIT, KITLG, VEGFA, CDKN2A, MAPK10, IFNG
36	dexamethasone32 42 34 9 9	10.0	TGFB1, AREG, HGF, DLK1, TJP1, GHR
37	genistein32 9 18 9	8.7	PTEN, CDKN2A, SST, TJP1, KITLG, IFNG
38	paclitaxel32 34 9 9	8.3	KIT, KITLG, VEGFA, BMP6, HGF, TGFB1
39	cisplatin32 34 9 9	8.3	TP73, PTEN, KRT8, EGF, EGFR, TYMP
40	paraffin32	4.4	CDKN2A, CD34, MMP13, MLANA, MITF, MET
41	cycloheximide32	3.6	CNTN2, PTEN, SST, KRT8, EGF, EGFR
42	dmso32	INF	NES, BMP6, TP73, TYR, , KITLG
43	serine32	INF	MAPK10, HGF, GAPDH, MYH11, NEU1, TGFB1
44	tgf beta132	INF	HGF, PTEN, TJP1, BMP6, KITLG, VCAN
45	retinoic acid32 42 18	INF	BMP6, S100B, B2M, CDKN2A, CD34, MMP13
46	progesterone32 42 9 18 9	INF	NF2, EGF, EGFR, TYMP, , NES
47	calcium32 9 18 9	INF	MAPK10, CLDN3, CNTN2, DLK1, HGF, RASA2
48	12-o-tetradecanoylphorbol 13-acetate32	INF	CD34, MMP13, MITF, AREG, MBP, BMP6
49	steroid32	INF	B2M, APOD, S100B, CDKN2A, KITLG, CNTN2
50	tyrosine32	INF	KITLG, VEGFA, BMP6, RASA2, S100A1, S100B

Cellular components related to neurofibroma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	INF	PTEN, , NF2, PDGFRA, PDPN, EGF
2	neuronal cell body	GO:043025	9.1	TGFB1, SST, GHR, MBP, APOD, MET
3	perinuclear region of cytoplasm	GO:048471	8.9	GAPDH, TYR, EGFR, NF2, APOD, CD34
4	platelet alpha granule lumen	GO:031093	8.2	HGF, TGFB1, EGF, F13A1, VEGFA
5	extracellular region	GO:005576	6.7	F13A1, GHR, SST, EGF, TGFB1, IFNG
6	extracellular space	GO:005615	5.5	CNP, HGF, TGFB1, EGFR, EGF, SST
7	cytoplasm	GO:005737	INF	, NF1, NF2, PDGFRA, KRT8, EGFR

Biological processes related to neurofibroma according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell-matrix adhesion	GO:001953	10.2	NF2, NF1, CDKN2A
2	cell chemotaxis	GO:060326	9.9	KIT, PDGFRA, HGF
3	negative regulation of hydrogen peroxide-mediated programmed cell death	GO:1901299	9.9	HGF, MET
4	positive regulation of DNA replication	GO:045740	9.7	KITLG, MET, GLI1, PDGFRA, EGFR
5	digestive tract morphogenesis	GO:048546	9.7	GLI1, TP73, EGFR
6	activation of MAPK activity	GO:000187	9.6	HGF, TP73, GHR, MAPK10, MET, KIT
7	positive regulation of gene expression	GO:010628	9.2	TGFB1, ANK3, MET, CD34, VEGFA, KIT
8	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.1	KITLG, VEGFA, GHR, HGF
9	positive regulation of peptidyl-threonine phosphorylation	GO:010800	9.1	MET, EGF, TGFB1
10	cell proliferation	GO:008283	8.9	TYR, EGFR, PDPN, PTEN, MET, ISG20
11	response to drug	GO:042493	8.8	NES, TGFB1, SST, IFNG, APOD, MET
12	positive regulation of cell migration	GO:030335	8.7	TGFB1, EGFR, PDPN, PDGFRA, VEGFA
13	platelet degranulation	GO:002576	8.4	HGF, TGFB1, EGF, F13A1, VEGFA
14	positive regulation of MAP kinase activity	GO:043406	8.2	TGFB1, EGFR, EGF, VEGFA, KITLG
15	positive regulation of cell proliferation	GO:008284	7.6	TGFB1, EGFR, EGF, PDGFRA, PTEN, GLI1

Molecular functions related to neurofibroma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	KIT, TJP1, PTEN, , NF1, NF2
2	platelet-derived growth factor receptor binding	GO:005161	9.3	TYMP, PDGFRA, VEGFA
3	identical protein binding	GO:042802	9.2	TP73, S100B, S100A1, CLDN3, CLDN5, CNTN2
4	protein homodimerization activity	GO:042803	8.3	TGFB1, TYR, PDGFRA, GHR, MSH6, S100B
5	protein heterodimerization activity	GO:046982	7.7	HGF, TGFB1, TYR, EGFR, MET, BMP6
6	growth factor activity	GO:008083	7.6	HGF, TGFB1, TYMP, EGF, BMP6, VEGFA