Neurofibromatosis malady

NIH Rare Diseases: Neurofibromatosis (NF) is a genetic neurological disorder that can affect the brain, spinal cord, nerves and skin. Tumors, or neurofibromas, grow along the body's nerves or on or underneath the skin. There are three types of neurofibromatosis: Neurofibromatosis type 1 (NF1) causes skin changes and deformed bones and usually starts at birth. Neurofibromatosis type 2 (NF2) causes hearing loss, ringing in the ears and poor balance. It often starts in the teen years. Schwannomatosis causes intense pain. It is the rarest type. Neurofibromatosis can either be an inherited disorder or the product of a gene mutation. Both NF1 and NF2 are caused by two separate abnormal genes and may be inherited from parents who have NF or may be the result of a mutation in the sperm or egg cells. NF is considered an autosomal dominant disorder.The gene for NF1 is located on chromosome 17. The gene for NF2 is located on chromosome 22. There is no cure for neurofibromatosis. Treatment is aimed at controlling symptoms. Depending on the type of disease and how bad it is, treatment may include surgery to remove tumors, radiation therapy and medicines.³⁰

MalaCards: Neurofibromatosis, also known as bilateral acoustic neurofibromatosis, is related to neuroma and t-cell leukemia. An important gene associated with Neurofibromatosis is NF1 (neurofibromin 1), and among its related pathways are Pancreatic cancer and Renal cell carcinoma. The compounds phenylalanine and dopamine have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and spinal cord, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

MedlinePlus: Neurofibromatosis is a genetic disorder of the nervous system. it mainly affects how nerve cells form and grow. it causes tumors to grow on nerves. you can get neurofibromatosis from your parents, or it can happen because of a mutation (change) in your genes. once you have it, you can pass it along to your children. there are three types of neurofibromatosis: type 1 (nf1) causes skin changes and deformed bones and usually starts at birth. type 2 (nf2) causes hearing loss, ringing in the ears and poor balance. it often starts in the teen years. schwannomatosis causes intense pain. it is the rarest type. there is no cure. treatment is aimed at controlling symptoms. depending on the type of disease and how bad it is, treatment may include surgery to remove tumors, radiation therapy and medicines. nih: national institute of neurological disorders and stroke²³

NINDS: The neurofibromatoses are genetic disorders that cause tumors to grow in the nervous system. ³¹

Genetics Home Reference: Neurofibromatosis type 2 is a disorder characterized by the growth of noncancerous tumors in the nervous system. The most common tumors associated with neurofibromatosis type 2 are called vestibular schwannomas or acoustic neuromas. These growths develop along the nerve that carries information from the inner ear to the brain (the auditory nerve). Tumors that occur on nerves in other areas of the brain or spinal cord are also commonly seen with this condition.¹⁷

Wikipedia: Neurofibromatosis (commonly abbreviated NF; neurofibromatosis type 1 is also known as von Recklinghausen...⁴⁴ more...

OMIM: 162200

GeneReviews summary for nf1

GeneReviews summary for nf2

Aliases & Descriptions:

neurofibromatosis 6 7 44 30 17 31 8 32 23 bilateral acoustic neurofibromatosis 44 15 30 16 17 von recklinghausen disease 44 15 30 16 17 peripheral neurofibromatosis 6 44 16 17 neurofibromatosis type 2 6 30 17 32 neurofibromatosis type 1 6 30 17 32 nf2 15 30 16 17 nf1 15 30 16 17 central neurofibromatosis 6 15 17 neurofibromatosis type ii 44 15 30 neurofibromatosis 2 15 16 43 neurofibromatosis 1 6 15 43 banf 44 16 17 von recklinghausen's neurofibromatosis 15 16 schwannoma, acoustic, bilateral 44 17 neurofibromatosis central type 30 16 acoustic schwannomas bilateral 30 16 recklinghausen disease, nerve 44 17 familial acoustic neuromas 17 43 type 1 neurofibromatosis 30 16 neurofibromatosis type 4 6 30

acoustic neuroma 17 43 vestibular schwannoma neurofibromatosis 16 type iv neurofibromatosis of riccardi 6 neurofibromatosis type 4 of riccardi 30 recklinghausen's neurofibromatosis 6 acoustic neurinoma bilateral 30 von recklinghausen's disease 31 neurofibromatosis, atypical 30 multiple neurofibromatosis 44 acoustic neurofibromatosis 6 von reklinghausen disease 6 familial acoustic neuroma 44 neurofibromatosis, type 2 33 neurofibromatosis, type 1 33 neurofibromatosis type iv 6 recklinghausen's disease 30 neurofibromatosis type i 44 neurofibromatoses 43 neurilemmoma 43 nf 2 16 nf 1 16

Disease types for neurofibromatosis family:

neurofibromatosis type 3a	neurofibromatosis type 3b
neurofibromatosis type 5	neurofibromatosis type 6

Diseases related to neurofibromatosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 895)

id	Related Disease	Score	Top Affiliating Genes
1	neuroma	35.4	RET, RDX, VHL, S100B, B2M, MSH2
2	t-cell leukemia	33.4	MYC, RAF1, BLZF1, CDK2, CDK4, CCND3
3	malignant peripheral nerve sheath tumor	32.4	KIT, VIM, S100B, CDKN2B, CDKN2A, CD34
4	plexiform neurofibroma	31.3	MMP13, NF1, PDGFRA
5	noonan syndrome	31.3	RAF1, MAPK1, IGFBP3, HRAS, GHR, PTPN11
6	ovarian cancer	30.9	BRCA1, BRCA2, CDK2, CDKN2B, CDKN2A, CDK4
7	somatostatinoma	30.5	CHGA, MEN1, ENO2, SST, SSTR2, ACTC1
8	neurofibroma	30.5	KIT, KITLG, VIM, VEGFA, RASA2, UTP6
9	acute lymphoblastic leukemia	30.4	RECK, KIT, KITLG, RAN, MSH2, CDK2
10	colorectal cancer	30.3	MSH2, MLH1, HRAS, TP53, CYP2D6, TGFB1
11	human t-cell leukemia virus type 1	30.3	MYC, RAN, BLZF1, CDK2, CDK4, CD44
12	burkitt's lymphoma	30.2	MYC, CDK4, CD44, CCND3, EZR, PTPN11
13	myeloproliferative disorder	30.2	KIT, KITLG, RAP1A, RAN, HRAS, PTPN11
14	chronic myelomonocytic leukemia	30.0	KIT, KITLG, PTPN11, NF1, PDGFRA, RUNX1
15	perineurioma	29.8	KIT, VIM, B3GAT1, S100B, CD34, NF2
16	multiple endocrine neoplasia type 2a	29.7	RET, VHL, NF1, ACTC1, GDNF
17	pancreatic cancer	29.7	RET, BRCA2, VEGFA, RAF1, RAN, RAC1
18	sotos syndrome	29.5	LRRC37B, ATAD5, IGFBP3, TEFM, CRLF3, NF1
19	microphthalmia	29.4	KIT, S100B, MAPK10, MAPK1, GJA1, SMARCA4
20	multiple endocrine neoplasia	29.4	RET, BRCA1, BRCA2, VHL, SDHB, SDHC
21	b-cell lymphomas	29.3	MYC, BLZF1, CDK2, CDKN2B, CDKN2A, CDK4
22	optic nerve glioma	29.1	FABP7, TNFRSF11B, NES
23	pulmonic stenosis	29.0	RAF1, HRAS, PTPN11, NF1, KRAS
24	spindle cell sarcoma	28.9	VIM, S100B, ACTC1, DES
25	hypercalcemia	28.9	VIM, CHGA, B2M, MEN1, IL6, TNFRSF11B
26	hemimegalencephaly	28.9	MYC, PTEN, CREB1, TSC2, PSMC4, WISP1
27	meninges hemangiopericytoma	28.8	VIM, IGFBP3, NF2, DES, EPB41L3
28	non-hodgkin lymphoma	28.8	KITLG, MYC, B2M, MSH2, CDKN2B, CD34
29	cafe-au-lait spots	28.8	KITLG, MSH2, MSH6, MLH1, PTPN11, NF1
30	brain cancer	28.7	CD44, GJA1, EGFR, PMS2
31	leopard syndrome	28.6	RAF1, HRAS, AKT1, PTPN11, NF1, ACP1
32	oligodendroglioma	28.6	CDKN2B, CDKN2A, PTEN, EGFR, GFAP
33	ganglioneuroma	28.6	RET, VHL, CHGA, S100B, CD44, ENO2
34	acoustic neuroma	28.6	VHL, B2M, MSH2, MKI67, IL6, SST
35	carney triad	28.6	KIT, SDHB, SDHC, SDHD, PDGFRA, PDPN
36	juvenile myelomonocytic leukemia	28.5	RASA2, RAF1, RASA1, HRAS, TP53, PTEN
37	fibrous meningioma	28.4	S100B, NF2, DES
38	prostate carcinoma	28.4	BRCA2, VEGFA, RASA2, ERBB2, TP53, TERT
39	parkinson's disease	28.4	BLVRB, BLZF1, FMR1, APP, AKT1, CYP2D6
40	muscular dystrophy	28.3	SGCG, VIM, VEGFA, VCL, CELF1, APP
41	short stature	28.3	RAF1, SDC2, MMP13, FMR1, IGF1R, IGFBP3
42	anaplastic ependymoma	28.2	S100B, PTEN, NF2, GFAP
43	vaccinia	28.1	KIF5B, KITLG, VCL, RAN, S100B, MAPK1
44	myelodysplastic syndrome	28.1	KIT, KITLG, RAP1A, RAN, CDKN2B, CD34
45	atypical neurofibroma	28.1	CD34, NF1, PDPN
46	glomus tumor	28.1	VIM, VHL, SDHB, SDHD, S100B, CDKN2B
47	cystic fibrosis	28.1	RECK, BRCA1, VEGFA, MSN, AREG, GSN
48	neuroendocrine tumor	27.9	RET, RAF1, SDHD, CHGA, MKI67, MEN1
49	cellular schwannoma	27.9	VIM, S100B, NF1, NF2, GFAP
50	influenza	27.9	RECK, RAF1, BLZF1, PAK1, B2M, IL6

Clinical features from OMIM: 162200

Approved drugs:

Drug clinical trials:

Genetic tests related to neurofibromatosis:

id	Genetic test	Affiliating Genes
1	Neurofibromatosis clinical/research	NF1, NF2

MalaCards organs/tissues related to neurofibromatosis:

²²

MGI Mouse Phenotypes related to neurofibromatosis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.7	RET, KIF5B, BRCA1, BRCA2, YAP1, CELF1
2	respiratory system phenotype	MP:0005388	10.5	SH3BP2, RET, BRCA1, GSN, ICAM2, CASK
3	craniofacial phenotype	MP:0005382	10.4	SH3BP2, KIT, KITLG, RASA1, MEN1, MAP3K11
4	hematopoietic system phenotype	MP:0005397	10.0	SH3BP2, KIT, BRCA1, BRCA2, VHL, RAP1A
5	other phenotype	MP:0005395	9.9	RECK, CDKN2A, APP, GJA1, DLK1, SPP1
6	renal/urinary system phenotype	MP:0005367	9.6	RET, KIT, BRCA1, VHL, CHGA, CDKN2B
7	hearing/vestibular/ear phenotype	MP:0005377	9.6	KIT, KITLG, RDX, MYC, RASA1, MDK
8	limbs/digits/tail phenotype	MP:0005371	9.2	RECK, RET, KIT, KITLG, BRCA1, BRCA2
9	normal phenotype	MP:0002873	9.1	RET, BRCA1, BRCA2, VHL, VEGFA, MYC
10	embryogenesis phenotype	MP:0005380	9.1	RECK, RET, KIT, KIF5B, VIM, BRCA1
11	pigmentation phenotype	MP:0001186	8.3	KIT, KITLG, BRCA1, MYC, RAC1, CDKN2A
12	behavior/neurological phenotype	MP:0005386	8.2	SGCG, KIT, RDX, VIM, VIPR2, BRCA2
13	liver/biliary system phenotype	MP:0005370	8.1	SH3BP2, RECK, KIT, RDX, VHL, VEGFA
14	no phenotypic analysis	MP:0003012	7.8	RET, VEGFA, MYC, RASA1, CD44, APP
15	reproductive system phenotype	MP:0005389	7.7	RET, VIPR2, BRCA1, BRCA2, VHL, VEGFA
16	nervous system phenotype	MP:0003631	7.6	SH3BP2, RECK, KIT, KITLG, RDX, BRCA1
17	digestive/alimentary phenotype	MP:0005381	7.6	SH3BP2, RET, KIT, KITLG, BRCA1, BRCA2
18	integument phenotype	MP:0010771	7.4	SH3BP2, RECK, KIT, KITLG, BRCA1, BRCA2
19	immune system phenotype	MP:0005387	7.2	KIT, VIM, VIPR2, BRCA1, BRCA2, RAP1A
20	adipose tissue phenotype	MP:0005375	6.7	VIPR2, BRCA1, MYC, IL6, IGF1R, IGFBP3
21	tumorigenesis	MP:0002006	6.5	RET, KIT, KITLG, BRCA1, BRCA2, VHL
22	vision/eye phenotype	MP:0005391	6.2	SH3BP2, KIT, KITLG, VIM, VEGFA, RAF1
23	skeleton phenotype	MP:0005390	6.2	SH3BP2, RECK, SGCG, KIT, KITLG, BRCA1
24	mortality/aging	MP:0010768	5.5	SH3BP2, RECK, RET, SGCG, KIF5B, KITLG
25	growth/size phenotype	MP:0005378	5.3	RECK, RET, SGCG, KIT, KIF5B, KITLG
26	muscle phenotype	MP:0005369	4.7	SH3BP2, RET, SGCG, KIT, VIM, BRCA1
27	cellular phenotype	MP:0005384	4.2	SH3BP2, RET, SGCG, KIT, KIF5B, KITLG
28	cardiovascular system phenotype	MP:0005385	3.5	RECK, RET, SGCG, KIT, KITLG, VIM
29	homeostasis/metabolism phenotype	MP:0005376	2.6	SH3BP2, RET, SGCG, KIT, KIF5B, KITLG

Articles related to neurofibromatosis:

(show top 50)    (show all 468)

id	Title	Authors	Year	Affiliating Genes
1	NF1 microdeletions in neurofibromatosis type 1: from genotype to phenotype. (20513137)	Pasmant E.... Vidaud D.	2010	NF1
2	The course of cognitive-behavioral development in chi ldren with the FMR1 mutation, Williams-Beuren syndrome, and neurofibromatosis t ype 1: The effect of gender. (20503326)	Fisch G.S.... Simensen R.	2010	FMR1
3	A novel mutation of the IL12RB1 gene in a child with nocardiosis, recurrent salmonellosis and neurofibromatosis type I: first case r eport from Thailand. (19839503)	Luangwedchakarn V.... Fleisher T.A.	2009	IL12RB1
4	Molecular characterization of permanent cell lines from primary, metastatic and recurrent malignant peripheral nerve sheath tumors (MPNST) with underlying neurofibromatosis-1. (19414372)	Fang Y.... Jhanwar S.C.	2009	NF1
5	Neurofibromatosis 2 [Bilateral acoustic neurofibromat osis, central neurofibromatosis, NF2, neurofibromatosis type II]. (19652604)	Evans D.G.	2009	NF2
6	Tranilast, an anti-allergic drug, down-regulates the growth of cultured neurofibroma cells derived from neurofibromatosis type 1. (19282654)	Yamamoto M.... Yamamoto Y.	2009	TGFB1, KITLG, AREG
7	Identification of mutations in the NF2 gene in Polish patients with neurofibromatosis type 2. (18670066)	L/aniewski-Wol/l/k M.... Szpecht-Potocka A.	2008	NF2
8	Neurofibromatosis: novel and recurrent mutations in Turkish patients. (18021924)	Terzi Y.K.... Ayter S.	2007	NF1
9	Mid-aortic syndrome with renovascular hypertension and multisystem involvement in a girl with familiar neurofibromatosis von Recklinghausen type 1. (18063929)	Petrak B.... Marikova T.	2007	NF1
10	Mitotic recombination as evidence of alternative pathogenesis of gastrointestinal stromal tumours in neurofibromatosis type 1. (17209131)	Stewart D.R.... Brooks D.G.	2007	PDGFRA, KIT
11	Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2. (16409122)	Messerli S.M.... Breakefield X.O.	2006	NF2
12	Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons. (17114577)	Walker J.A.... Bernards A.	2006	NF1
13	The spectrum of NF1 mutations in Korean patients with neurofibromatosis type 1. (16479075)	Jeong S.Y.... Kim H.J.	2006	NF1
14	Absence of c-kit gene mutations in gastrointestinal stromal tumours from neurofibromatosis type 1 patients. (14694524)	Kinoshita K.... Matsuzawa Y.	2004	KIT
15	Characterization of the somatic mutational spectrum of the neurofibromatosis type 1 (NF1) gene in neurofibromatosis patients with benign and malignant tumors. (14722917)	Upadhyaya M.... Cooper D.N.	2004	CDKN2A
16	HNPCC mutation MLH1 P648S makes the functional protein unstable, and homozygosity predisposes to mild neurofibromatosis type 1. (15139004)	Raevaara T.E.... Nystroem-Lahti M.	2004	MLH1
17	NF1 exon 7 skipping and sequence alterations in exonic splice enhancers (ESEs) in a neurofibromatosis 1 patient. (13680360)	Colapietro P.... Larizza L.	2003	NF1, SRSF2
18	Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. (12077339)	Bajenaru M.L.... Gutmann D.H.	2002	NF1
19	Localization of the 17q breakpoint of a constitutiona l 1;17 translocation in a patient with neuroblastoma within a 25-kb segment loc ated between the ACCN1 and TLK2 genes and near the distal breakpoints of two mi crodeletions in neurofibromatosis type 1 patients. (12203774)	Van Roy N.... Speleman F.	2002	AA06
20	C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both the type II transcript and apobec-1, the catalytic subunit of the apolipoprotein B mRNA-editing enzyme. (11727199)	Mukhopadhyay D.... Davidson N.O.	2002	NF1, APOB, APOBEC1
21	Aetiology of spinal deformities in neurofibromatosis 1: new hypotheses. (11359370)	Abdel-Wanis M.E.... Kawahara N.	2001	NF1
22	Mosaic (segmental) neurofibromatosis type 1 (NF1) and type 2 (NF2): no longer neurofibromatosis type 5 (NF5). (11391665)	Ruggieri M.	2001	NF2
23	Mild familial neurofibromatosis 2 associates with expression of merlin with altered COOH-terminus. (10720287)	Sainio M.... CarpAcn O.	2000	NF2
24	Human MLH1 deficiency predisposes to hematological malignancy and neurofibromatosis type 1. (9927033)	Ricciardone M.D.... OztA1rk M.	1999	MLH1
25	Fetal antigen 1, a member of the epidermal growth factor superfamily, in neurofibromas and serum from patients with neurofibromatosis type 1. (10354070)	Jensen C.H.... Rasmussen H.B.	1999	DLK1
26	Mouse tumor model for neurofibromatosis type 1. (10591653)	Vogel K.S.... Parada L.F.	1999	TP53, NF1
27	Site-specific DNA methylation in the neurofibromatosis (NF1) promoter interferes with binding of CREB and SP1 transcription factors. (10435592)	Mancini D.N.... Rodenhiser D.I.	1999	CREB1
28	A rare combination of pheochromocytoma ans somatostatin-rich neuroendocrine tumor of Vater's papilla (carcinoid) in a patient with von Recklinghausen neurofibromatosis (9577907)	Hardt P.D.... Hinrichs B.	1998	NF1, SST
29	Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli. (9516485)	Shaw R.J.... Jacks T.	1998	NF2
30	Localization and functional domains of the neurofibromatosis type II tumor suppressor, merlin. (9563848)	Shaw R.J.... Jacks T.	1998	RDX
31	Neurofibromatosis versus schwannomatosis (9676422)	Mautner V.F.... Kluwe L.	1998	NF1, NF2
32	A clinical variant of neurofibromatosis type 1: familial spinal neurofibromatosis with a frameshift mutation in the NF1 gene. (9529361)	Ars E.... Estivill X.	1998	NF1
33	Loss of the NF2 gene and merlin occur by the tumorlet stage of schwannoma development in neurofibromatosis 2. (9862639)	Stemmer-Rachamimov A.O.... Louis D.N.	1998	NF2
34	Mutational and functional analysis of the neurofibromatosis type 1 (NF1) gene. (9003501)	Upadhyaya M.... Cooper D.N.	1997	NF1
35	Skin abnormalities in neurofibromatosis 2. (9420538)	Mautner V.F.... Gottschalk J.	1997	NF1
36	The neurofibromatosis type I messenger RNA undergoes base- modification RNA editing. (8602361)	Skuse G.R.... Smith H.C.	1996	NF1
37	Phosphorylation of neurofibromatosis type 1 gene product (neurofibromin) by cAMP-dependent protein kinase. (8612763)	Izawa I.... Saya H.	1996	NF1
38	Evidence for the presence of two amino-terminal isoforms of neurofibromin, a gene product responsible for neurofibromatosis type 1. (7570581)	Suzuki H.... Shibahara S.	1995	NF1
39	The comparison between the growth fraction of bilater al vestibular schwannomas in neurofibromatosis 2 (NF2) and unilateral vestibula r schwannomas using the monoclonal antibody MIB 1. (7668124)	Aguiar P.H.... Ostertag H.	1995	MKI67
40	Genomic organization of the neurofibromatosis 1 gene (NF1). (7774960)	Li Y.... Viskochil D.	1995	NF1
41	Neurofibromatosis type 2 protein co-localizes with elements of the cytoskeleton. (7485397)	den Bakker M.A.... Zwarthoff E.C.	1995	NF2, RDX
42	Multiple transcripts of the neurofibromatosis type 1 gene in human brain and in brain tumours. (7874833)	Takahashi K.... Shibahara S.	1994	NF1
43	Mutational analysis of patients with neurofibromatosis 2. (7913580)	MacCollin M.M.... Gusella J.F.	1994	NF2
44	The neurofibromatosis type 2 gene is inactivated in schwannomas. (8162016)	Twist E.C.... Rouleau G.A.	1994	NF2
45	Molecular cloning and characterization of alternatively spliced transcripts of the mouse neurofibromatosis 2 gene. (7506121)	Hara T.... Kley N.	1994	NF2
46	Ring chromosome 22 and neurofibromatosis. (1424240)	Tommerup N.... Petersen G.B.	1992	NF1
47	Recurrence of a nonsense mutation in the NF1 gene causing classical neurofibromatosis type 1. (1757093)	Estivill X.... Ravella A.	1991	NF1
48	The neurofibroma in von Recklinghausen neurofibromatosis has a unicellular origin. (1715669)	Skuse G.R.... Rowley P.T.	1991	NF1
49	Type 1 neurofibromatosis gene: correction. (2125369)		1990	NF1
50	Progress toward the isolation and characterization of the genes causing neurofibromatosis. (1669691)	Menon A.G.... Seizinger B.R.	1990	NF1, NF2

Genes related to neurofibromatosis according to GeneCards:

(show top 50)    (show all 197)

id	Symbol	Description	Score	GeneCards Section Context
1	NF1	neurofibromin 1	11.1	Summaries, Orthologs, Aliases & Descriptions, Publications
2	NF2	neurofibromin 2 (merlin)	11.1	Summaries, Publications, Orthologs
3	APOBEC1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1	11.0	Summaries, Publications
4	RNF135	ring finger protein 135	11.0	Summaries, Publications
5	SPRED1	sprouty-related, EVH1 domain containing 1	11.0	Summaries, Publications
6	CRTAC1	cartilage acidic protein 1	11.0	Summaries, Publications
7	NF1L1P	neurofibromatosis type 1 pseudogene	11.0	Aliases & Descriptions
8	PTPN11	protein tyrosine phosphatase, non-receptor type 11	11.0	Publications
9	CRLF3	cytokine receptor-like factor 3	11.0	Summaries, Publications
10	SDHD	succinate dehydrogenase complex, subunit D, integral membrane protein	11.0	Publications
11	SDHB	succinate dehydrogenase complex, subunit B, iron sulfur (Ip)	11.0	Publications
12	RASA2	RAS p21 protein activator 2	11.0	Publications
13	RASA1	RAS p21 protein activator (GTPase activating protein) 1	11.0	Publications
14	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
15	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.0	Publications
16	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0	Publications
17	RET	ret proto-oncogene	11.0	Publications
18	CREB1	cAMP responsive element binding protein 1	11.0	Publications
19	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	11.0	Publications
20	OMG	oligodendrocyte myelin glycoprotein	11.0	Publications
21	HGS	hepatocyte growth factor-regulated tyrosine kinase substrate	11.0	Publications
22	RDX	radixin	11.0	Publications
23	SDCBP	syndecan binding protein (syntenin)	11.0
24	MSN	moesin	11.0	Publications
25	EZR	ezrin	11.0	Publications
26	PMS2	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	11.0	Publications
27	ETV5	ets variant 5	11.0	Publications
28	CCL7	chemokine (C-C motif) ligand 7	11.0
29	TSC1	tuberous sclerosis 1	11.0	Publications
30	KIT	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	11.0	Publications
31	SLC9A3R1	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1	11.0
32	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa	11.0
33	EPOR	erythropoietin receptor	11.0
34	GDNF	glial cell derived neurotrophic factor	11.0	Publications
35	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications
36	MLH1	mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)	11.0	Publications
37	MSH6	mutS homolog 6 (E. coli)	11.0	Publications
38	NGFR	nerve growth factor receptor	11.0	Publications
39	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
40	MEN1	multiple endocrine neoplasia I	11.0
41	KITLG	KIT ligand	11.0	Publications
42	PXN	paxillin	11.0	Publications
43	BLZF1	basic leucine zipper nuclear factor 1	11.0
44	RECK	reversion-inducing-cysteine-rich protein with kazal motifs	11.0
45	S100B	S100 calcium binding protein B	11.0	Publications
46	KRT14	keratin 14	11.0
47	SPTBN1	spectrin, beta, non-erythrocytic 1	11.0	Publications
48	MSH2	mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)	11.0	Publications
49	EPB41L3	erythrocyte membrane protein band 4.1-like 3	11.0
50	SST	somatostatin	11.0	Publications

Pathways related to neurofibromatosis according to GeneDecks:

(show top 50)    (show all 275)

id	Pathway	Score	Top Affiliating Genes
1	Pancreatic cancer20	11.0	BRCA2
2	Renal cell carcinoma20	10.8	RAP1A, PAK1, RAC1, HRAS, VHL, RAF1
3	Translation Regulation activity of EIF4F10	10.6	PAK1
4	EGFR Inhibitor Pathway, Pharmacodynamics34	10.6	KRAS, HRAS
5	Neuroscience3	10.5	DPYSL2, APP, FABP7, FMR1, S100B, VHL
6	Colorectal cancer20	10.3	MSH2, MSH6, TGFB1, RAC1
7	Akt Signaling36	10.2	RAF1, IGF1R, KIT, YAP1, IL12RB1, IL6
8	Translation _Regulation of EIF4F activity41	10.1	TSC2, TSC1, AKT1, HRAS, MAP3K11, RAC1
9	Development EPO-induced MAPK pathway10	10.0	KRAS, EPOR, KIT, KITLG, RAP1A, RAF1
10	Development_EPO-induced MAPK pathway41	10.0	KIT, KITLG, RAP1A, RAF1, RAC1, EPOR
11	Development FGFR signaling pathway10	10.0	SDC2, MAPK10, MAPK1, MAP3K11, HRAS, AKT1
12	Development_FGFR signaling pathway41	10.0	RAF1, CREB1, PTPN11, AKT1, HRAS, MAP3K11
13	Paxillin Interactions36	9.6	EGFR, ERBB2, PDGFRA, AREG, PXN, EPHA3
14	Development_IGF-1 receptor signaling41	9.4	IGF1R, IGFBP3, HRAS, AKT1, PTEN, TSC1
15	Development_EGFR signaling via small GTPases41	9.4	MYC, RAF1, MAPK10, MAPK1, HRAS, ERBB2
16	Development IGF-RI signaling10	9.4	CCND3, TSC1, MYC, RAF1, MAPK1, PTEN
17	Breast Cancer Regulation by Stathmin136	9.3	NRP2, IGF1R, MAPK10, PAK1, RAF1, ERBB2
18	JNK Pathway36	9.1	MAPK10, IL6, MAP3K11, HRAS, TP53, PDGFRA
19	14-3-3 Induced Intracellular Signaling36	9.0	MAPK10, KITLG, RAF1, YAP1, AKT1, AREG
20	Rac1 Pathway36	9.0	RAF1, TGFB1, NRP2, PAK1, KITLG, IGF1R
21	Development EGFR signaling via small GTPases10	8.9	RAF1, ERBB2, HRAS, MAPK1, KRAS, MAPK10
22	Development_EGFR signaling pathway41	8.9	EGFR, HBEGF, STAT3, MYC, ERBB2, HRAS
23	Development Neurotrophin family signaling10	8.9	AKT1, RAF1, TP53, RAC1, HRAS, NGFR
24	Ras Pathway36	8.9	KIT, RAF1, RASA1, RAP1A, EPHA3, EGFR
25	EGF Pathway36	8.8	STAT3, PAK1, MAPK10, RAC1, RAF1, MYC
26	Focal adhesion20	8.8	CCND3, MAPK1, MAPK10, PAK1, RAF1, VCL
27	Development_Neurotrophin family signaling41	8.8	AKT1, HRAS, MAPK1, MAPK10, RAC1, RAF1
28	Glioblastoma Multiforme36	8.4	HRAS, AKT1, TP53, PTEN, NF1, NF2
29	Glioma20	8.4	CDKN2A, RAF1, IGF1R, EGFR, KRAS, PDGFRA
30	PTEN Pathway36	8.4	PTEN, NRP2, NGFR, PDGFRA, EGFR, PXN
31	Melanoma20	8.4	PTEN, EGFR, PDGFRA, TP53, AKT1, HRAS
32	ErbB signaling pathway20	8.3	AKT1, ERBB2, MAPK10, KRAS, EGFR, HBEGF
33	ILK Signaling36	8.3	MAPK10, MDK, AREG, CDH13, RAC1, VIM
34	Chronic myeloid leukemia20	8.3	HRAS, MYC, CDKN2A, CDK4, MAPK1, AKT1
35	p70S6K Signaling36	8.3	MAPK1, MAPK10, MDK, IL6, TGFB1, IGF1R
36	Endometrial cancer20	8.2	EGFR, MYC, RAF1, MLH1, MAPK1, HRAS
37	Renin-Angiotensin Pathway36	8.2	STAT3, MAPK10, MAPK1, CCL7, IGF1R, HRAS
38	Prostate cancer20	8.1	PTEN, AKT1, RAF1, CDK2, KRAS, MAPK1
39	MAPK signaling pathway20	8.1	MAPK1, EGFR, TGFB1, KRAS, RASA2, RAF1
40	GPCR Pathway36	7.9	MAPK10, CREB1, IGF1R, MAPK1, AREG, RAP1A
41	Estrogen Pathway36	7.8	ERBB2, BRCA1, EPOR, RAF1, PRKAR1A, TGFB1
42	ERK Signaling36	7.8	AREG, IL6, PAK1, RAP1A, KITLG, MYC
43	Bladder cancer20	7.7	CDK4, MYC, VEGFA, KRAS, TP53, HRAS
44	JAK-STAT Pathway36	7.6	EPHA3, KIT, AKT1, HRAS, IGF1R, STAT3
45	Telomerase Components in Cell Signaling36	7.6	KIT, TGFB1, MYC, AREG, IL6, MDK
46	Rho Family GTPases36	7.2	IL6, EPOR, KIT, PDGFRA, SPP1, TNC
47	Molecular Mechanisms of Cancer36	6.7	BRCA1, CCL7, IGF1R, HRAS, AKT1, TP53
48	Pancreatic Adenocarcinoma36	6.6	TP53, ERBB2, AKT1, IGF1R, CCND3, MAPK1
49	MAPK Signaling36	6.5	IL6, ERBB2, HRAS, IGF1R, MAP3K11, MAPK1
50	Pathways in cancer20	6.1	MAPK10, CDK4, CDKN2B, CDK2, MSH2, RAC1

Compounds related to neurofibromatosis according to GeneDecks:

(show top 50)    (show all 313)

id	Compound	Score	Top Affiliating Genes
1	phenylalanine32	10.9	RASA2, RASA1, BLZF1, PXN, SOAT1, GALK1
2	dopamine32 9 18 9	13.3	RET, RAF1, BLVRB, SDHB, S100B, CDKN2A
3	glucose32	10.2	KIT, VHL, VCL, BLVRB, PAK1, S100B
4	gtp32	10.1	RECK, RDX, RAP1A, RASA2, RASA3, RAF1
5	leucine32	9.7	RECK, RET, KIT, VIM, MYC, RAC1
6	superoxide32 18	10.7	KITLG, RAP1A, RAN, RAC1, BLVRB, BLZF1
7	nitric oxide32 9 18 9	12.5	KIT, KITLG, VHL, VCL, RAP1A, BLVRB
8	atp32	9.4	RECK, RET, KIT, KIF5B, BRCA1, VCL
9	hematoxylin32	9.4	KIT, VIM, BLVRB, CHGA, S100B, CDKN2A
10	arginine32	9.4	RECK, RET, RAP1A, RAN, RAC1, RASA1
11	aspartate32	9.3	RET, VIM, RAF1, SDHB, S100B, B2M
12	iron32 18	10.3	RECK, KITLG, VIM, VHL, BLVRB, BLZF1
13	hyaluronic acid32 18	10.3	RDX, VIM, MYC, RAC1, B2M, MSN
14	agar32	9.2	RET, KITLG, VIM, BRCA1, RAP1A, RAC1
15	cysteine32	9.2	RECK, BRCA1, VCL, RAF1, RAN, RAC1
16	cytochalasin d32 42	10.2	KITLG, VIM, VCL, RAF1, RAC1, PAK1
17	choline32 9 18 9	12.1	RET, VIM, RAF1, BLVRB, S100B, APOB
18	bromodeoxyuridine32	9.0	KITLG, VIM, MYC, CHGA, S100B, CDK2
19	proline32	9.0	VIM, BRCA1, BRCA2, VHL, VCL, RAC1
20	acetylcholine32 9 18 9	12.0	VIM, VCL, RAF1, RAC1, BLVRB, BLZF1
21	glycogen32 18	9.9	KIT, VIM, VHL, MYC, SDHB, CHGA
22	12-o-tetradecanoylphorbol 13-acetate32	8.8	RET, VCL, MYC, RAP1A, RAF1, CD34
23	sb 20358032 42	9.7	VIM, VEGFA, RAC1, CDK4, MMP13, AREG
24	wortmannin32 42	9.6	RET, KITLG, VIM, VCL, RAF1, RAC1
25	oxygen32 18	9.5	KITLG, BRCA1, RAP1A, RAN, RAC1, BLVRB
26	phosphotyrosine32	8.5	RECK, RET, KIT, RDX, BRCA1, VCL
27	cholesterol32 9 18 9	11.3	RECK, KITLG, RAC1, BLZF1, SDHB, SDHC
28	estrogen32	8.3	RDX, BRCA1, BRCA2, VHL, RAF1, PAK1
29	phosphoinositide32	8.2	KIT, VIM, VCL, RAP1A, RAF1, RAC1
30	calcium32 9 18 9	11.2	RECK, KIT, KITLG, RDX, BRCA1, VHL
31	herbimycin a32 42	9.0	RET, KITLG, MYC, RAF1, CDK2, CDK4
32	glutamate32	7.9	VIM, BLVRB, BLZF1, PAK1, SDCBP, SDHB
33	alanine32	7.9	RET, KITLG, BRCA1, MYC, RAF1, RASA1
34	lipid32	7.9	RECK, RET, KIF5B, KITLG, RDX, VIM
35	matrigel32	7.7	VIM, BRCA2, VEGFA, VCL, RAC1, CHGA
36	n acetylcysteine32	7.7	RAF1, CDKN2A, CDK4, FOSL2, AREG, MAPK10
37	glutamine32	7.7	KIT, VIM, BRCA1, BRCA2, VCL, RAP1A
38	creatinine32	7.2	KITLG, VIM, SDHB, CHGA, S100B, B2M
39	imatinib32 34 9 9	10.0	RET, KIT, KITLG, VEGFA, MYC, RAF1
40	pd 98,05932	6.8	RECK, RET, KIT, KITLG, MYC, RAF1
41	retinoic acid32 42 18	8.8	RET, KIT, KITLG, BRCA1, BRCA2, MYC
42	5fluorouracil32	6.5	KIT, KITLG, BRCA1, VEGFA, MSH2, CDK2
43	butyrate32	6.5	RET, KITLG, VIM, MYC, RAF1, BLZF1
44	thymidine32 18	7.1	KIT, KITLG, BRCA1, BRCA2, MYC, RAF1
45	actinomycin d32	6.1	KIT, KITLG, VIM, VHL, VEGFA, MYC
46	paraffin32	5.7	RET, KIT, KITLG, VIM, BRCA1, BRCA2
47	genistein32 9 18 9	8.6	RET, KITLG, VIM, BRCA1, BRCA2, VEGFA
48	testosterone32 9 18 9	8.6	RET, KIT, KITLG, VIM, BRCA1, BRCA2
49	tamoxifen32 34 9 9	8.2	VIM, BRCA1, BRCA2, VEGFA, MYC, RAF1
50	curcumin32	5.1	VEGFA, MYC, RAF1, CDK2, CDK4, MMP13

Cellular components related to neurofibromatosis according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	extrinsic to membrane	GO:019898	10.9	EPB41L3, EPB41, NF2, GHR, EZR, MSN
2	ruffle	GO:001726	10.7	SLC9A3R1, PDPN, EZR, GSN, S100B, PAK1
3	lamellipodium	GO:030027	10.7	PXN, TSC1, PDPN, NF2, AKT1, GSN
4	mitochondrial respiratory chain complex II	GO:005749	10.6	SDHB, SDHC, SDHD
5	microvillus membrane	GO:031528	10.6	SLC9A3R1, PDPN, EZR, MSN
6	filopodium membrane	GO:031527	10.4	GAP43, PDPN, NF2, MSN
7	focal adhesion	GO:005925	10.0	PXN, EZR, MAPK1, MSN, SDCBP, PAK1
8	perinuclear region of cytoplasm	GO:048471	9.5	SPP1, NF2, EGFR, TSC2, CX3CR1, GAPDH
9	axon	GO:030424	9.4	NF1, TGFB1, NEFH, GAP43, NOV, NRP2
10	protein complex	GO:043234	9.1	TSC1, TOP2A, DPYSL2, SYP, PRKAR1A, SOX9
11	nucleolus	GO:005730	8.4	CREB1, SMARCB1, SPTBN1, SPRED1, TBL1XR1, TERT
12	plasma membrane	GO:005886	7.9	SPTBN1, NRP2, NGFR, NF2, PDGFRA, SPRED1
13	nucleoplasm	GO:005654	7.6	AKT1, TP53, TERT, TBL1XR1, SRSF2, SMARCB1
14	extracellular space	GO:005615	7.5	SPP1, SST, DLK1, TNXB, TNFRSF11B, EGFR
15	extracellular region	GO:005576	7.5	SPP1, SST, CYR61, TNFRSF11B, TNC, NOV
16	cytosol	GO:005829	7.3	KRT14, RHOD, RNF135, NGFR, SPTBN1, PTPN11
17	cytoplasm	GO:005737	6.0	GAPDH, KRT14, PDGFRA, RNF135, NF2, NF1
18	nucleus	GO:005634	5.5	CRYBA1, NLK, NF1, NF2, NFIC, NFIX

Biological processes related to neurofibromatosis according to GeneDecks:

(show all 46)

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell-matrix adhesion	GO:001953	10.9	NF2, NF1, CASK, CDKN2A, RASA1
2	actin cytoskeleton organization	GO:030036	10.8	EPB41, SLC9A3R1, SHROOM3, KRAS, NF2, NF1
3	activation of MAPKK activity	GO:000186	10.8	RAF1
4	negative regulation of cell migration	GO:030336	10.7	SLC9A3R1, CX3CR1, NF2, NF1, PTEN, GTPBP4
5	hemopoiesis	GO:030097	10.6	RUNX1, MEN1, CD34, BRCA2, KITLG, KIT
6	protein stabilization	GO:050821	10.5	GAPDH, TSC1, CREB1, PTEN, GTPBP4, CDKN2A
7	insulin-like growth factor receptor signaling pathway	GO:048009	10.4	TSC2, GHR, AKT1, IGF1R
8	fibroblast growth factor receptor signaling pathway	GO:008543	10.3	CREB1, KRAS, TSC2, PRKAR1A, PTPN11, PTEN
9	extracellular matrix organization	GO:030198	10.3	SOX9, GFAP, NF1, SMARCA4, CYR61, TNFRSF11B
10	wound healing	GO:042060	10.3	PDGFRA, NF1, ERBB2, SDC2, PAK1, RAF1
11	heart development	GO:007507	10.2	GJA1, ERBB2, PTEN, NRP2, NF1, TSC2
12	insulin receptor signaling pathway	GO:008286	10.2	TSC2, TSC1, KRAS, PTPN11, AKT1, HRAS
13	phosphatidylinositol-mediated signaling	GO:048015	10.1	TOP2A, TSC2, PDGFRA, CREB1, PTEN, ERBB2
14	protein kinase B signaling cascade	GO:043491	10.1	SOX9, TGFB1, TSC2, PTEN, AKT1
15	nerve growth factor receptor signaling pathway	GO:048011	10.1	NGFR, KRAS, TSC2, STAT3, PRKAR1A, OMG
16	response to wounding	GO:009611	10.1	GAP43, CX3CR1, TGFB1, GFAP, NGFR, TNC
17	positive regulation of fibroblast proliferation	GO:048146	10.0	CDK4, FOSL2, NGFR, PDGFRA, EGFR, MYC
18	cell adhesion	GO:007155	10.0	PXN, OMG, CX3CR1, WISP1, WISP2, EPHA3
19	response to estradiol stimulus	GO:032355	9.9	OXT, STAT3, DHH, TGFB1, GHR, ENO2
20	positive regulation of DNA replication	GO:045740	9.8	KITLG, IGF1R, HRAS, PDGFRA, EGFR
21	lamellipodium assembly	GO:030032	9.7	CDH13, RAC1, VCL, KIT
22	protein autophosphorylation	GO:046777	9.7	EGFR, PDGFRA, NLK, ERBB2, AKT1, IGF1R
23	response to gamma radiation	GO:010332	9.7	TP53, APOBEC1, MEN1, MYC, BRCA2
24	axon guidance	GO:007411	9.6	NRP2, CREB1, NGFR, KRAS, EGFR, DPYSL2
25	positive regulation of protein phosphorylation	GO:001934	9.6	SOX9, TGFB1, KRAS, CYR61, ERBB2, AKT1
26	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.6	TGFB1, AKT1, IL6, CD44, PAK1, RAF1
27	response to drug	GO:042493	9.6	CREB1, ACTC1, TOP2A, TGFB1, DPYSL2, STAT3
28	Ras protein signal transduction	GO:007265	9.4	KRAS, NF1, TP53, HRAS, MAPK1, CDKN2A
29	MAPK cascade	GO:000165	9.3	TGFB1, EGFR, KRAS, NF1, HRAS, MAPK1
30	cell cycle arrest	GO:007050	9.2	TGFB1, MYC, MSH2, CDKN2B, CDKN2A, MEN1
31	positive regulation of cell cycle arrest	GO:071158	9.2	TGFB1, CRLF3, TP53, CDKN2A, BRCA1
32	positive regulation of epithelial cell proliferation	GO:050679	9.1	SOX9, TGFB1, EGFR, ERBB2, HRAS, MYC
33	epidermal growth factor receptor signaling pathway	GO:007173	9.1	HBEGF, TSC2, TGFB1, PXN, PRKAR1A, SOX9
34	positive regulation of MAP kinase activity	GO:043406	9.0	TGFB1, EGFR, KRAS, ERBB2, VEGFA, KITLG
35	positive regulation of cell migration	GO:030335	8.8	TGFB1, HBEGF, EGFR, PDPN, PDGFRA, CYR61
36	cell proliferation	GO:008283	8.7	ERBB2, TP53, PTEN, CYR61, PDPN, EGFR
37	negative regulation of cell proliferation	GO:008285	8.6	TP53, PTEN, SST, SSTR2, NF2, TSC1
38	apoptotic process	GO:006915	8.5	TP53, TNFRSF11B, PTEN, NGB, NGFR, ACTC1
39	signal transduction	GO:007165	8.4	GDNF, EGFR, PDPN, CREB1, TNXB, TNFRSF11B
40	platelet activation	GO:030168	8.1	TGFB1, AKT1, MAPK1, APP, IL6, RAC1
41	positive regulation of cell proliferation	GO:008284	8.0	PTEN, SUZ12, PDGFRA, KRAS, EGFR, TIAL1
42	virus-host interaction	GO:019048	8.0	CX3CR1, STAT3, TGFB1, PDGFRA, CREB1, SMARCB1
43	positive regulation of transcription, DNA-dependent	GO:045893	8.0	TP53, TBL1XR1, SMARCA4, CREB1, CRLF3, TGFB1
44	negative regulation of apoptotic process	GO:043066	7.9	PTEN, CYR61, EGFR, CX3CR1, SOX9, NES
45	blood coagulation	GO:007596	7.6	AKAP1, AKT1, TP53, PTPN11, KRAS, HBG2
46	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.2	SMARCA4, SMARCB1, CREB1, CRLF3, NFIC, NFIX

Molecular functions related to neurofibromatosis according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	four-way junction DNA binding	GO:000400	10.6	MSH2, MSH6, MEN1
2	structural constituent of eye lens	GO:005212	10.5	CRYBB3, CRYBB2, CRYBA4, CRYBA1, VIM
3	insulin-like growth factor binding	GO:005520	10.3	WISP2, WISP1, NOV, CYR61, IGFBP3, IGF1R
4	structural constituent of cytoskeleton	GO:005200	10.1	EPB41, DES, GFAP, KRT14, SPTBN1, MSN
5	protein homodimerization activity	GO:042803	9.6	TERT, CRYBA1, CRYBB2, PDGFRA, TSC2, TOP2A
6	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.5	EGFR, PDGFRA, ERBB2, KIT, RET
7	heparin binding	GO:008201	9.4	HBEGF, NRP2, CYR61, TNXB, CCL7, APP
8	protein kinase binding	GO:019901	9.2	STAT3, DPYSL2, SPRED1, PTEN, TP53, GHR
9	protein N-terminus binding	GO:047485	9.0	TGFB1, TSC1, SMARCA4, TBL1XR1, TP53, MEN1
10	identical protein binding	GO:042802	8.4	TP53, CRYBB2, EGFR, SYP, OMG, EPOR
11	enzyme binding	GO:019899	8.1	TP53, PTEN, EGFR, TOP2A, TGFB1, AKT1
12	protein heterodimerization activity	GO:046982	7.1	RUNX1, TGFB1, TOP2A, EGFR, TP53, ERBB2
13	ATP binding	GO:005524	7.1	PDGFRA, NLK, SMARCA4, TP53, ERBB2, AKT1
14	protein binding	GO:005515	3.7	CASK, SRSF2, SPRED1, SPTBN1, SMARCA4, SMARCB1