MCID: NRF003
MIFTS: 45

Neurofibrosarcoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Neurofibrosarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A malignant peripheral nerve sheath tumor (MPNST) (also known as \"Malignant schwannoma,\"... more...

MalaCards: Neurofibrosarcoma, also known as malignant peripheral nerve sheath tumor, is related to melanoma and neurofibromatosis. An important gene associated with Neurofibrosarcoma is MXI1 (MAX interactor 1, dimerization protein), and among its related pathways is Glioblastoma Multiforme. The compounds azathioprine and guanosine have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and small intestine, and related mouse phenotypes are hearing/vestibular/ear and tumorigenesis.

Aliases & Classifications for Neurofibrosarcoma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

neurofibrosarcoma 8 9 42 46 10 44
malignant peripheral nerve sheath tumor 60
neurosarcoma 8


External Ids:

Disease Ontology8 DOID:3512
SNOMED-CT56 404037002, 19897006
MeSH34 D018319

Related Diseases for Neurofibrosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Neurofibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma31.1NF2, NF1, MXI1, TP73
2neurofibromatosis30.8NF2, NF1
3gastrointestinal stromal tumor30.6NF1, NF2
4adenocarcinoma30.4DCK, NF2, MXI1, TP73
5malignant peripheral nerve sheath tumor30.3NF1
6neurofibroma30.3NF2, NF1, TP73
7plexiform neurofibroma29.8TP73, NF1
8ovarian cancer29.8DCK, NF2, TP73
9epithelioid malignant peripheral nerve sheath tumor11.0
10peripheral nerve schwannoma10.9
11malignant triton tumor10.8
12synovial sarcoma10.7
13ganglioneuroma10.7
14perineurioma10.6
15cervicitis10.5
16malignant glandular tumor of peripheral nerve sheath10.4
17hepatitis a10.4
18hepatitis10.4
19malignant mesothelioma10.4
20neuroblastoma10.4
21thyroiditis10.4
22malignant cardiac peripheral nerve sheath neoplasm10.3
23malignant oculomotor nerve tumor10.3
24malignant peritoneal mesothelioma10.3
25malignant spindle cell melanoma10.3
26papillary carcinoma10.3
27cellular schwannoma10.3
28plexiform schwannoma10.3
29smooth muscle tumor10.3
30malignant epithelial mesothelioma10.3
31cervix melanoma10.3
32bladder carcinoma in situ10.3
33meningocele10.3
34intussusception10.3
35aortic malignant tumor10.3
36monophasic synovial sarcoma10.3
37fibrous synovial sarcoma10.3
38melanocytic psammomatous mpnst10.3
39small cell sarcoma10.3
40horner's syndrome10.3
41bladder carcinoma10.3
42bladder disease10.3
43complex regional pain syndrome10.3
44dermatomyositis10.3
45gallbladder adenocarcinoma10.3
46hodgkin's lymphoma10.3
47in situ carcinoma10.3
48liposarcoma10.3
49lung cancer10.3
50malignant leptomeningeal tumor10.3

Graphical network of the top 20 diseases related to Neurofibrosarcoma:



Diseases related to neurofibrosarcoma

Clinical Features for Neurofibrosarcoma

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Drugs & Therapeutics for Neurofibrosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Neurofibrosarcoma

Drug clinical trials:

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Genetic Tests for Neurofibrosarcoma

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Anatomical Context for Neurofibrosarcoma

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32MalaCards
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MalaCards organs/tissues related to Neurofibrosarcoma:

32
Breast, Bone, Small intestine, Liver, Skin, Ovary, Prostate, Tongue

Animal Models for Neurofibrosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neurofibrosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1TP73, NF1, NF2
2MP:00020068.8TP73, MXI1, NF1, NF2
3MP:00053678.7NF2, NF1, INSRR, MXI1
4MP:00053798.4TP73, MXI1, NF1, NF2
5MP:00053878.0DCK, NF2, NF1, MXI1, TP73

Publications for Neurofibrosarcoma

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50PubMed
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Articles related to Neurofibrosarcoma:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Neurofibrosarcoma of the gallbladder: a case report. (23938157)
2013
2
Gross and histopathological characteristics of two lipomas and a neurofibrosarcoma detected in aquacultured southern bluefin tuna, Thunnus maccoyii (Castelnau), in South Australia. (18353015)
2008
3
The genetic predisposition to and histogenesis of neurofibromas and neurofibrosarcoma in neurofibromatosis type 1. (17613220)
2007
4
Neurofibrosarcoma - complicating neurofibromatosis-I: case report and review of relevant literature. (16160727)
2005
5
Pediatric neurofibrosarcoma. (12632346)
2003
6
Retroperitoneal neurofibrosarcoma in a patient with neurofibromatosis. 2: A case report and review of the literature. (14692188)
2003
7
Aberrant CpG island methylation in neurofibromas and neurofibrosarcomas. (12883734)
2003
8
Cerebral air emboli in a child with neurofibrosarcoma. (10227545)
1999
9
Neurofibrosarcoma-derived Schwann cells overexpress platelet-derived growth factor (PDGF) receptors and are induced to proliferate by PDGF BB. (9766530)
1998
10
Removal of a thymoma via median sternotomy in a rabbit with recurrent appendicular neurofibrosarcoma. (9787381)
1998
11
Case 3: Neurofibromatosis I with metastases from a thigh neurofibrosarcoma. (9725330)
1998
12
Case report: isolated neurofibrosarcoma of the liver: US, CT and MR findings. (9112953)
1997
13
Metastatic multicentric neurofibrosarcoma of the lumbosacral plexus in a cow. (8740716)
1996
14
Bone scans in neurofibromatosis: neurofibroma, plexiform neuroma and neurofibrosarcoma. (8917174)
1996
15
Orbital neurofibrosarcoma: a case report. (8919474)
1995
16
Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis. (8499945)
1993
17
Neurofibrosarcoma of the intrathoracic vagus nerve. Case report. (8211005)
1993
18
Involvement of 22q12 in a neurofibrosarcoma in neurofibromatosis type 1. (8467471)
1993
19
Treatment of a large high-grade neurofibrosarcoma with concomitant vinblastine, doxorubicin, and radiotherapy. (1435843)
1992
20
von Recklinghausen's neurofibromatosis with neurofibrosarcoma. (1900842)
1991
21
Pigmented neurofibrosarcoma mimicking a large haemangioma. (1806329)
1991
22
Bronchial neurofibrosarcoma. (1929641)
1991
23
Immunohistochemical localization of type I, III, IV, V, and VI collagens and laminin in neurofibroma and neurofibrosarcoma. (1928621)
1991
24
Chromosomes 17 and 22 involved in marker formation in neurofibrosarcoma in von Recklinghausen disease. A cytogenetic and in situ hybridization study. (2118474)
1990
25
A case of neurofibrosarcoma associated with neurofibromatosis: light microscopic, ultrastructural, immunohistochemical and biochemical investigations. (2116469)
1990
26
Neurofibrosarcoma of skin and subcutaneous tissues. (1689440)
1990
27
Neurofibrosarcoma complicating pregnancy. (2502488)
1989
28
Malignant schwannoma (neurofibrosarcoma) metastatic to spine. Surgical decompression and stabilization. (2727803)
1989
29
Neurofibrosarcoma as a complication of von Recklinghausen neurofibromatosis. (2517529)
1989
30
Rapidly progressive neurofibrosarcoma. (6723630)
1984
31
Neurofibrosarcoma in a 19-year-old cat. (6612976)
1983
32
Postirradiation neurofibrosarcoma. (6821867)
1983
33
Update on biologic behavior and surgical implications of neurofibromatosis and neurofibrosarcoma. (6405495)
1983
34
Neurofibrosarcoma and irradiation. (6288200)
1982
35
CT demonstration of a neurofibrosarcoma causing femoral neuropathy. (6815243)
1982
36
Morphological studies in malignant tumors of the peripheral nervous system (neurofibrosarcoma, malignant schwannoma, schwann cell sarcoma). (6939219)
1981
37
Neurofibrosarcoma of the hypoglossal nerve. (1176827)
1975
38
Sacral neurofibrosarcoma: an angiographic evaluation. Case report. (4826602)
1974
39
Neurofibrosarcoma of the orbit (malignant change in a plexiform neurofibromatosis). (4199807)
1972
40
Neurofibrosarcoma of sciatic nerve. (5508532)
1970
41
Hydromyelia in Von Recklinghausen's disease with neurofibrosarcoma. (4976961)
1969
42
Establishment and characterization of a feline neurofibrosarcoma (FNFS) cell line. (5813750)
1969
43
Neurofibrosarcoma of the prostate: a case report. (13752403)
1961
44
Digital neurofibrosarcoma in infancy. (13476342)
1957
45
Presacral neurofibrosarcoma. (13092362)
1953
46
CLINICAL pathologic conference; neurofibrosarcoma of the breast. (14804072)
1951
47
Neurofibrosarcoma of the vagus nerve; report of a case. (15405150)
1950
48
Neurofibrosarcoma of the anterior mediastinum; surgical removal. (15437582)
1950
49
Neurofibrosarcoma of the neck; report of case with ten year survival after roentgen therapy. (14771327)
1950
50
Retroperitoneal neurofibrosarcoma]. (20255856)
1947

Genetic Variations for Neurofibrosarcoma

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Expression for genes affiliated with Neurofibrosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurofibrosarcoma

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Pathways for genes affiliated with Neurofibrosarcoma

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51QIAGEN
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Pathways related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NF1, NF2

Compounds for genes affiliated with Neurofibrosarcoma

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44Novoseek, 49PharmGKB, 2BitterDB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1azathioprine44 49 2 1112.4TP73, DCK
2guanosine44 11 2411.3DCK, NF1
3gemcitabine44 49 1111.3TP73, DCK
4paraffin449.2TP73, NF1, NF2
5progesterone44 59 28 11 2412.8TP73, NF1, NF2
6tyrosine448.1TP73, INSRR, NF1, NF2, DCK

GO Terms for genes affiliated with Neurofibrosarcoma

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16Gene Ontology
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Biological processes related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-matrix adhesionGO:0019539.5NF1, NF2
2negative regulation of cell migrationGO:0303369.5NF1, NF2
3negative regulation of MAPK cascadeGO:0434099.4NF1, NF2
4negative regulation of protein kinase activityGO:0064699.2NF1, NF2

Products for genes affiliated with Neurofibrosarcoma

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Sources for Neurofibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet