MCID: NRF003
MIFTS: 48

Neurofibrosarcoma malady

Rare diseases, Cancer diseases, Neuronal diseases categories
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Summaries for Neurofibrosarcoma

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Wikipedia:65 A malignant peripheral nerve sheath tumor (MPNST) (also known as \"Malignant schwannoma,\"... more...

MalaCards based summary: Neurofibrosarcoma, also known as malignant peripheral nerve sheath tumor, is related to neurofibromatosis and malignant peripheral nerve sheath tumor. An important gene associated with Neurofibrosarcoma is MXI1 (MAX interactor 1, dimerization protein), and among its related pathways are Hippo signaling pathway and Glioblastoma Multiforme. The compounds gemcitabine and guanosine have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and small intestine, and related mouse phenotypes are hearing/vestibular/ear and tumorigenesis.

Aliases & Classifications for Neurofibrosarcoma

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Neurofibrosarcoma, Aliases & Descriptions:

Name: Neurofibrosarcoma 8 9 42 46 10 44
Malignant Peripheral Nerve Sheath Tumor 62
 
Neurosarcoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:3512
SNOMED-CT57 404037002, 19897006
MeSH34 D018319

Related Diseases for Neurofibrosarcoma

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Diseases related to Neurofibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis31.2NF1, NF2
2malignant peripheral nerve sheath tumor30.8NF1, NF2
3neurofibroma30.5NF2, TP73, NF1
4sarcoma30.3NF1, DCK, NF2
5ovarian cancer29.7DCK, TP73, NF2
6nervous system cancer10.2NF1, NF2
7acoustic neuroma10.2NF2, NF1
8plexiform neurofibroma10.2NF1, TP73
9multiple endocrine neoplasia10.2NF1, NF2
10pilocytic astrocytoma10.2TP73, NF1
11gastrointestinal stromal tumor10.2NF1, NF2
12neurilemmoma10.2NF1, NF2
13hypoglycemia10.1
14mediastinitis10.1
15ependymoma10.0NF2, NF1, TP73
16meningioma10.0NF2, NF1, TP73
17malignant glioma10.0NF2, NF1
18astrocytoma10.0NF2, NF1, TP73
19myeloid leukemia10.0MXI1, NF1, TP73
20ankylosing spondylitis10.0
21myasthenia gravis10.0
22wilms tumor10.0
23childhood malignant schwannoma10.0
24endocervicitis10.0
25hyperinsulinemic hypoglycemia10.0
26graves' disease10.0
27adult malignant schwannoma10.0
28femoral neuropathy10.0
29cerebritis10.0
30spindle cell sarcoma10.0
31angiosarcoma10.0
32leiomyosarcoma10.0
33lipoma10.0
34neuroma10.0
35neuropathy10.0
36prostatitis10.0
37spondylitis10.0
38thymoma10.0
39pheochromocytoma10.0
40soft tissue sarcoma10.0
41hydromyelia10.0
42myoclonus10.0
43hematologic cancer9.9DCK, TP73
44colorectal cancer9.9NF2, TP73, NF1
45glioblastoma9.9TP73, NF1, MXI1
46lung adenocarcinoma9.9DCK, TP73
47osteosarcoma9.9TP73, DCK, NF2
48prostate cancer9.9NF2, TP73, MXI1
49ipex syndrome9.8TP73, DCK, NF2
50brain cancer9.8NF1, TP73, NF2, MXI1

Graphical network of the top 20 diseases related to Neurofibrosarcoma:



Diseases related to neurofibrosarcoma

Symptoms for Neurofibrosarcoma

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Drugs & Therapeutics for Neurofibrosarcoma

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Drug clinical trials:

Search ClinicalTrials for Neurofibrosarcoma

Search NIH Clinical Center for Neurofibrosarcoma

Genetic Tests for Neurofibrosarcoma

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Anatomical Context for Neurofibrosarcoma

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MalaCards organs/tissues related to Neurofibrosarcoma:

32
Breast, Bone, Small intestine, Liver, Skin, Ovary, Prostate, Tongue

Animal Models for Neurofibrosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Neurofibrosarcoma:

36 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.9NF1, NF2, TP73
2MP:00020068.7MXI1, NF1, NF2, TP73
3MP:00053678.7INSRR, NF2, NF1, MXI1
4MP:00053898.7INSRR, TP73, NF2, MXI1
5MP:00053798.6MXI1, NF1, NF2, TP73
6MP:00053828.6NF1, NF2, TP73
7MP:00053768.1INSRR, TP73, NF2, NF1, MXI1
8MP:00053848.1MXI1, NF1, DCK, TP73
9MP:00107688.0INSRR, TP73, NF2, NF1, MXI1
10MP:00053978.0TP73, DCK, NF1, MXI1
11MP:00053877.8TP73, DCK, NF2, NF1, MXI1

Publications for Neurofibrosarcoma

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Articles related to Neurofibrosarcoma:

(show top 50)    (show all 121)
idTitleAuthorsYear
1
Molecular characteristics and pathogenicity of an avian leukosis virus isolated from avian neurofibrosarcoma. (22545526)
2012
2
Neurofibrosarcoma - complicating neurofibromatosis-I: case report and review of relevant literature. (16160727)
2005
3
Pediatric neurofibrosarcoma. (12632346)
2003
4
Metastatic spinal neurofibrosarcoma. (11880913)
2002
5
Association of soft tissue sarcomas other than neurofibrosarcoma with neurofibromatosis. (12555884)
2002
6
Posterior mediastinal neurofibrosarcoma in a patient with von Recklinghausen's disease. (10413818)
1999
7
Case report: isolated neurofibrosarcoma of the liver: US, CT and MR findings. (9112953)
1997
8
Metastatic multicentric neurofibrosarcoma of the lumbosacral plexus in a cow. (8740716)
1996
9
Bone scans in neurofibromatosis: neurofibroma, plexiform neuroma and neurofibrosarcoma. (8917174)
1996
10
Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis. (8499945)
1993
11
Treatment of a large high-grade neurofibrosarcoma with concomitant vinblastine, doxorubicin, and radiotherapy. (1435843)
1992
12
von Recklinghausen's neurofibromatosis with neurofibrosarcoma. (1900842)
1991
13
Pigmented neurofibrosarcoma mimicking a large haemangioma. (1806329)
1991
14
A case of neurofibrosarcoma associated with neurofibromatosis--ganglioside analysis. (1806326)
1991
15
Chromosomes 17 and 22 involved in marker formation in neurofibrosarcoma in von Recklinghausen disease. A cytogenetic and in situ hybridization study. (2118474)
1990
16
A novel population of cells in the peripheral blood of a cow with a neurofibrosarcoma. (2251765)
1990
17
Pigmented neurofibrosarcoma mimicking a large haemangioma. (2279344)
1990
18
A case of neurofibrosarcoma associated with neurofibromatosis: light microscopic, ultrastructural, immunohistochemical and biochemical investigations. (2116469)
1990
19
Neurofibrosarcoma complicating pregnancy. (2502488)
1989
20
Malignant schwannoma (neurofibrosarcoma) metastatic to spine. Surgical decompression and stabilization. (2727803)
1989
21
Neurofibrosarcoma [corrected] as a complication of NF-1. (3152467)
1988
22
Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis. (3100319)
1987
23
Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue. (3103455)
1987
24
Sacral neurofibrosarcoma--a case report. (3729850)
1986
25
Rapidly progressive neurofibrosarcoma. (6723630)
1984
26
Neurofibrosarcoma of the vagus nerve. (6844194)
1983
27
Neurofibrosarcoma and irradiation. (6288200)
1982
28
CT demonstration of a neurofibrosarcoma causing femoral neuropathy. (6815243)
1982
29
Neurofibrosarcoma of the cauda equina. Case report. (7463146)
1981
30
Morphological studies in malignant tumors of the peripheral nervous system (neurofibrosarcoma, malignant schwannoma, schwann cell sarcoma). (6939219)
1981
31
Neurofibrosarcoma of the duodenum in von Recklinghausen's disease. (105775)
1979
32
Neurofibrosarcoma of the radial nerve in von Recklinghausen's disease with metastatic angiosarcoma. (96219)
1978
33
Anal neurofibrosarcoma treated with fast neutron irradiation. (638549)
1978
34
Neurofibrosarcoma of the mandible. (266068)
1977
35
Morphologic aspects of the neurofibrosarcoma (neurogenic sarcoma). (98330)
1977
36
Clinical-pathological conference: Case 10, part 2. Neurofibrosarcoma. (1053649)
1975
37
Hyperinsulinemic hypoglycemia associated with a neurofibrosarcoma. (1130933)
1975
38
Neurofibrosarcoma of spermatic cord. (1168964)
1975
39
Sacral neurofibrosarcoma: an angiographic evaluation. Case report. (4826602)
1974
40
Neurogenic sarcoma (neurofibrosarcoma) of the tongue. (4742987)
1973
41
Neurofibrosarcoma of the orbit (malignant change in a plexiform neurofibromatosis). (4199807)
1972
42
Neurofibrosarcoma of sciatic nerve. (5508532)
1970
43
Hydromyelia in Von Recklinghausen's disease with neurofibrosarcoma. (4976961)
1969
44
Massive neurofibrosarcoma of the anterior abdominal wall. (4221755)
1966
45
Neurofibrosarcoma of the stomach. (13244990)
1955
46
Neurofibrosarcoma of the vagus nerve; report of a case. (15405150)
1950
47
Neurofibrosarcoma, with invasion of right innominate vein and superior vena cava. (18892591)
1948
48
Retroperitoneal neurofibrosarcoma]. (20255856)
1947
49
Neurofibrosarcoma of the small intestine associated with von Recklinghausen's disease. (20272751)
1947
50
NEUROFIBROSARCOMA OF THE SMALL BOWEL: REPORT OF TWO CASES. (17857318)
1939

Variations for Neurofibrosarcoma

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Expression for genes affiliated with Neurofibrosarcoma

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Expression patterns in normal tissues for genes affiliated with Neurofibrosarcoma

Search GEO for disease gene expression data for Neurofibrosarcoma.

Pathways for genes affiliated with Neurofibrosarcoma

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Pathways related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NF2, TP73
29.4NF1, NF2
3
Show member pathways
Signaling Pathways in Glioblastoma37
9.3NF1, INSRR

Compounds for genes affiliated with Neurofibrosarcoma

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Compounds related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gemcitabine44 50 1111.2DCK, TP73
2guanosine44 24 1111.2NF1, DCK
3azathioprine44 2 50 1112.2DCK, TP73
4vincristine44 50 1111.1TP73, DCK
55-aza-2deoxycytidine449.1DCK, TP73
6cytochalasin d44 6110.1NF1, NF2
7paraffin449.1TP73, NF2, NF1
8camptothecin44 61 1111.0DCK, TP73
9progesterone44 28 61 24 1113.0TP73, NF2, NF1
10tyrosine447.8NF1, NF2, DCK, TP73, INSRR

GO Terms for genes affiliated with Neurofibrosarcoma

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Cellular components related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056347.6MXI1, NF1, NF2, DCK, TP73

Biological processes related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-matrix adhesionGO:0019539.5NF1, NF2
2negative regulation of MAPK cascadeGO:0434099.4NF1, NF2
3actin cytoskeleton organizationGO:0300369.4NF1, NF2
4negative regulation of protein kinase activityGO:0064699.3NF2, NF1
5negative regulation of cell migrationGO:0303369.1NF1, NF2

Products for genes affiliated with Neurofibrosarcoma

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Sources for Neurofibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet