MCID: NRF003
MIFTS: 45

Neurofibrosarcoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Neurofibrosarcoma

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63Wikipedia, 32MalaCards
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Wikipedia:63 A malignant peripheral nerve sheath tumor (MPNST) (also known as \"Malignant schwannoma,\"... more...

MalaCards: Neurofibrosarcoma, also known as malignant peripheral nerve sheath tumor, is related to melanoma and neurofibromatosis. An important gene associated with Neurofibrosarcoma is MXI1 (MAX interactor 1, dimerization protein), and among its related pathways is Glioblastoma Multiforme. The compounds azathioprine and guanosine have been mentioned in the context of this disorder. Affiliated tissues include breast, skin and ovary, and related mouse phenotypes are hearing/vestibular/ear and tumorigenesis.

Aliases & Classifications for Neurofibrosarcoma

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8Disease Ontology, 9diseasecard, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

neurofibrosarcoma 8 9 42 46 10 44
malignant peripheral nerve sheath tumor 60
neurosarcoma 8


External Ids:

Disease Ontology8 DOID:3512
SNOMED-CT56 404037002, 19897006
MeSH34 D018319

Related Diseases for Neurofibrosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Neurofibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 101)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma31.1NF2, NF1, MXI1, TP73
2neurofibromatosis30.8NF2, NF1
3gastrointestinal stromal tumor30.6NF1, NF2
4adenocarcinoma30.4DCK, NF2, MXI1, TP73
5malignant peripheral nerve sheath tumor30.3NF1
6neurofibroma30.3NF2, NF1, TP73
7plexiform neurofibroma29.8TP73, NF1
8ovarian cancer29.8DCK, NF2, TP73
9epithelioid malignant peripheral nerve sheath tumor11.0
10peripheral nerve schwannoma10.9
11malignant triton tumor10.8
12synovial sarcoma10.7
13ganglioneuroma10.7
14perineurioma10.6
15cervicitis10.5
16malignant glandular tumor of peripheral nerve sheath10.4
17hepatitis a10.4
18hepatitis10.4
19malignant mesothelioma10.4
20neuroblastoma10.4
21thyroiditis10.4
22malignant cardiac peripheral nerve sheath neoplasm10.3
23malignant oculomotor nerve tumor10.3
24malignant peritoneal mesothelioma10.3
25malignant spindle cell melanoma10.3
26papillary carcinoma10.3
27cellular schwannoma10.3
28plexiform schwannoma10.3
29smooth muscle tumor10.3
30malignant epithelial mesothelioma10.3
31cervix melanoma10.3
32bladder carcinoma in situ10.3
33meningocele10.3
34intussusception10.3
35aortic malignant tumor10.3
36monophasic synovial sarcoma10.3
37fibrous synovial sarcoma10.3
38melanocytic psammomatous mpnst10.3
39small cell sarcoma10.3
40horner's syndrome10.3
41bladder carcinoma10.3
42bladder disease10.3
43complex regional pain syndrome10.3
44dermatomyositis10.3
45gallbladder adenocarcinoma10.3
46hodgkin's lymphoma10.3
47in situ carcinoma10.3
48liposarcoma10.3
49lung cancer10.3
50malignant leptomeningeal tumor10.3

Graphical network of the top 20 diseases related to Neurofibrosarcoma:



Diseases related to neurofibrosarcoma

Clinical Features for Neurofibrosarcoma

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Drugs & Therapeutics for Neurofibrosarcoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Neurofibrosarcoma

Genetic Tests for Neurofibrosarcoma

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Anatomical Context for Neurofibrosarcoma

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32MalaCards
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MalaCards organs/tissues related to Neurofibrosarcoma:

32
Breast, Skin, Ovary, Bone, Liver, Tongue, Small intestine, Prostate

Animal Models for Neurofibrosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Neurofibrosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1TP73, NF1, NF2
2MP:00020068.8TP73, MXI1, NF1, NF2
3MP:00053678.7NF2, NF1, INSRR, MXI1
4MP:00053798.4TP73, MXI1, NF1, NF2
5MP:00053878.0DCK, NF2, NF1, MXI1, TP73

Publications for Neurofibrosarcoma

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50PubMed
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Articles related to Neurofibrosarcoma:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Molecular characteristics and pathogenicity of an avian leukosis virus isolated from avian neurofibrosarcoma. (22545526)
2012
2
Endocervical fibroblastic malignant peripheral nerve sheath tumor (neurofibrosarcoma): report of a novel entity possibly related to endocervical CD34 fibrocytes. (21317712)
2011
3
Total sacrectomy and reconstruction with structural allografts for neurofibrosarcoma of the sacrum. A case report. (15805218)
2005
4
A study of the influence of newly synthesized acyclonucleosides and 1,2,3,4-tetrahydroisoquinoline derivatives on deoxythymidine and deoxycytidine kinase activities in human neurofibrosarcoma and ovarian cancer. (14740004)
2003
5
Metastatic spinal neurofibrosarcoma. (11880913)
2002
6
Association of soft tissue sarcomas other than neurofibrosarcoma with neurofibromatosis. (12555884)
2002
7
Neurofibrosarcoma in the nasal cavity. (23119773)
2001
8
Periocular neurofibrosarcoma in a horse. (11906658)
2001
9
Malignant spinal neurofibrosarcoma. (10752112)
2000
10
Posterior mediastinal neurofibrosarcoma in a patient with von Recklinghausen's disease. (10413818)
1999
11
Orbital neurofibrosarcoma in a dog. (11397256)
1999
12
Bone scans in neurofibromatosis: neurofibroma, plexiform neuroma and neurofibrosarcoma. (8917174)
1996
13
Paraneoplastic opsoclonus-myoclonus syndrome and neurofibrosarcoma. (8864716)
1996
14
Clonal karyotypic evolution in a pediatric neurofibrosarcoma. (7621409)
1995
15
von Recklinghausen's neurofibromatosis with neurofibrosarcoma. (1900842)
1991
16
A case of neurofibrosarcoma associated with neurofibromatosis--ganglioside analysis. (1806326)
1991
17
Oral neurofibrosarcoma associated with neurofibromatosis type I. (1923446)
1991
18
A novel population of cells in the peripheral blood of a cow with a neurofibrosarcoma. (2251765)
1990
19
Pigmented neurofibrosarcoma mimicking a large haemangioma. (2279344)
1990
20
Neurofibrosarcoma presenting as spontaneous haemothorax. (2119679)
1990
21
Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis. (3100319)
1987
22
Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue. (3103455)
1987
23
Rectus abdominis myocutaneous free-flap reconstruction following a cranio-orbital-maxillary resection for neurofibrosarcoma. (2959974)
1987
24
Sacral neurofibrosarcoma--a case report. (3729850)
1986
25
Neurofibrosarcoma and leiomyosarcoma in slaughterhouse broilers. (3927890)
1985
26
Neurofibrosarcoma and the sign of Leser-TrAclat. (6432241)
1984
27
Neurofibrosarcoma of the vagus nerve. (6844194)
1983
28
Computed tomography in retroperitoneal neurofibrosarcoma (malignant schwannoma). (6630653)
1983
29
Neurofibrosarcoma at irradiation site in a patient with neurofibromatosis and Wilms' tumor. (6286055)
1981
30
Neurofibrosarcoma of the duodenum in von Recklinghausen's disease. (105775)
1979
31
Bilateral trigeminal neurofibrosarcoma. Case report. (430141)
1979
32
Neurofibrosarcoma of the radial nerve in von Recklinghausen's disease with metastatic angiosarcoma. (96219)
1978
33
Anal neurofibrosarcoma treated with fast neutron irradiation. (638549)
1978
34
Morphologic aspects of the neurofibrosarcoma (neurogenic sarcoma). (98330)
1977
35
Neurofibrosarcoma complicating von Recklinghausen's disease. (820823)
1976
36
Clinical-pathological conference: Case 10, part 2. Neurofibrosarcoma. (1053649)
1975
37
Hyperinsulinemic hypoglycemia associated with a neurofibrosarcoma. (1130933)
1975
38
Neurofibrosarcoma following radiotherapy for ankylosing spondylitis. (1221941)
1975
39
Sacral neurofibrosarcoma: an angiographic evaluation. Case report. (4826602)
1974
40
Neurofibrosarcoma. (6078229)
1967
41
Massive neurofibrosarcoma of the anterior abdominal wall. (4221755)
1966
42
NEUROFIBROSARCOMA IN A DOG. (14329433)
1965
43
TRIGEMINAL NEUROFIBROSARCOMA: REPORT OF CASE. (14075488)
1963
44
Retroperitoneal pelvic neurofibrosarcoma. (13808579)
1960
45
Pheochromocytoma and neurofibrosarcoma in a patient with neurofibromatosis. (13732286)
1960
46
Mediastinal neurofibrosarcoma causing hypoglycemia. (14439307)
1959
47
Neurofibrosarcoma; report of a case in a seven-year-old girl. (13361526)
1956
48
Neurofibrosarcoma; a rare presacral tumor. (13201300)
1954
49
Neurofibrosarcoma of the facial nerve involving the tympanomastoid. (14856486)
1951
50
Primary neurofibrosarcoma of the diaphragm; report of two cases. (14785027)
1950

Genetic Variations for Neurofibrosarcoma

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Expression for genes affiliated with Neurofibrosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurofibrosarcoma

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Pathways for genes affiliated with Neurofibrosarcoma

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51QIAGEN
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Pathways related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NF1, NF2

Compounds for genes affiliated with Neurofibrosarcoma

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44Novoseek, 49PharmGKB, 2BitterDB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1azathioprine44 49 2 1112.4TP73, DCK
2guanosine44 11 2411.3DCK, NF1
3gemcitabine44 49 1111.3TP73, DCK
4paraffin449.2TP73, NF1, NF2
5progesterone44 59 28 11 2412.8TP73, NF1, NF2
6tyrosine448.1TP73, INSRR, NF1, NF2, DCK

GO Terms for genes affiliated with Neurofibrosarcoma

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16Gene Ontology
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Biological processes related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-matrix adhesionGO:0019539.5NF1, NF2
2negative regulation of cell migrationGO:0303369.5NF1, NF2
3negative regulation of MAPK cascadeGO:0434099.4NF1, NF2
4negative regulation of protein kinase activityGO:0064699.2NF1, NF2

Products for genes affiliated with Neurofibrosarcoma

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Sources for Neurofibrosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet