MCID: NRF003
MIFTS: 48

Neurofibrosarcoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Neurofibrosarcoma

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66Wikipedia, 34MalaCards
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Wikipedia:66 A malignant peripheral nerve sheath tumor (MPNST) (also known as \"Malignant schwannoma,\"... more...

MalaCards: Neurofibrosarcoma, also known as malignant peripheral nerve sheath tumor, is related to neurofibromatosis and malignant peripheral nerve sheath tumor. An important gene associated with Neurofibrosarcoma is MXI1 (MAX interactor 1, dimerization protein), and among its related pathways are Hippo signaling pathway and Glioblastoma Multiforme. The compounds gemcitabine and guanosine have been mentioned in the context of this disorder. Affiliated tissues include breast, bone and small intestine, and related mouse phenotypes are hearing/vestibular/ear and tumorigenesis.

Aliases & Classifications for Neurofibrosarcoma

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9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 48OMIM, 11DISEASES, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

neurofibrosarcoma 9 10 44 48 11 46
malignant peripheral nerve sheath tumor 63
neurosarcoma 9


External Ids:

Disease Ontology9 DOID:3512
SNOMED-CT59 404037002, 19897006
MeSH36 D018319

Related Diseases for Neurofibrosarcoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Neurofibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 59)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis31.0NF1, NF2
2malignant peripheral nerve sheath tumor30.5NF1, NF2
3sarcoma30.4NF1, DCK, NF2
4neurofibroma30.4NF2, TP73, NF1
5ovarian cancer29.9DCK, TP73, NF2
6hypoglycemia10.1
7mediastinitis10.1
8nervous system cancer10.1NF1, NF2
9acoustic neuroma10.1NF2, NF1
10plexiform neurofibroma10.1NF1, TP73
11multiple endocrine neoplasia10.0NF1, NF2
12pilocytic astrocytoma10.0TP73, NF1
13gastrointestinal stromal tumor10.0NF1, NF2
14neurilemmoma10.0NF1, NF2
15ependymoma10.0NF2, NF1, TP73
16meningioma10.0NF2, NF1, TP73
17malignant glioma10.0NF2, NF1
18astrocytoma10.0NF2, NF1, TP73
19myeloid leukemia10.0MXI1, NF1, TP73
20hematologic cancer10.0DCK, TP73
21colorectal cancer10.0NF2, TP73, NF1
22glioblastoma multiforme10.0TP73, NF1, MXI1
23lung adenocarcinoma10.0DCK, TP73
24osteosarcoma10.0TP73, DCK, NF2
25prostate cancer10.0NF2, TP73, MXI1
26ipex syndrome10.0TP73, DCK, NF2
27brain cancer10.0NF1, TP73, NF2, MXI1
28retinoblastoma10.0TP73, DCK, NF1
29ankylosing spondylitis10.0
30childhood malignant schwannoma10.0
31adult malignant schwannoma10.0
32spindle cell sarcoma10.0
33femoral neuropathy10.0
34cerebritis10.0
35endocervicitis10.0
36graves' disease10.0
37hyperinsulinemic hypoglycemia10.0
38angiosarcoma10.0
39leiomyosarcoma10.0
40lipoma10.0
41myasthenia gravis10.0
42neuroma10.0
43neuropathy10.0
44prostatitis10.0
45spondylitis10.0
46thymoma10.0
47pheochromocytoma10.0
48wilms tumor10.0
49soft tissue sarcoma10.0
50hydromyelia10.0

Graphical network of the top 20 diseases related to Neurofibrosarcoma:



Diseases related to neurofibrosarcoma

Symptoms for Neurofibrosarcoma

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Drugs & Therapeutics for Neurofibrosarcoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Neurofibrosarcoma

Drug clinical trials:

Search ClinicalTrials for Neurofibrosarcoma

Search NIH Clinical Center for Neurofibrosarcoma

Search CenterWatch for Neurofibrosarcoma

Genetic Tests for Neurofibrosarcoma

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Anatomical Context for Neurofibrosarcoma

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34MalaCards
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MalaCards organs/tissues related to Neurofibrosarcoma:

34
Breast, Bone, Small intestine, Liver, Skin, Ovary, Prostate, Tongue

Animal Models for Neurofibrosarcoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Neurofibrosarcoma:

38 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.9NF1, NF2, TP73
2MP:00020068.7MXI1, NF1, NF2, TP73
3MP:00053678.7INSRR, NF2, NF1, MXI1
4MP:00053898.7INSRR, TP73, NF2, MXI1
5MP:00053798.6MXI1, NF1, NF2, TP73
6MP:00053828.6NF1, NF2, TP73
7MP:00053768.1INSRR, TP73, NF2, NF1, MXI1
8MP:00053848.1MXI1, NF1, DCK, TP73
9MP:00107688.0INSRR, TP73, NF2, NF1, MXI1
10MP:00053978.0TP73, DCK, NF1, MXI1
11MP:00053877.8TP73, DCK, NF2, NF1, MXI1

Publications for Neurofibrosarcoma

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53PubMed
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Articles related to Neurofibrosarcoma:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Molecular characteristics and pathogenicity of an avian leukosis virus isolated from avian neurofibrosarcoma. (22545526)
2012
2
Neurofibrosarcoma - complicating neurofibromatosis-I: case report and review of relevant literature. (16160727)
2005
3
Pediatric neurofibrosarcoma. (12632346)
2003
4
Metastatic spinal neurofibrosarcoma. (11880913)
2002
5
Association of soft tissue sarcomas other than neurofibrosarcoma with neurofibromatosis. (12555884)
2002
6
Posterior mediastinal neurofibrosarcoma in a patient with von Recklinghausen's disease. (10413818)
1999
7
Case report: isolated neurofibrosarcoma of the liver: US, CT and MR findings. (9112953)
1997
8
Metastatic multicentric neurofibrosarcoma of the lumbosacral plexus in a cow. (8740716)
1996
9
Bone scans in neurofibromatosis: neurofibroma, plexiform neuroma and neurofibrosarcoma. (8917174)
1996
10
Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis. (8499945)
1993
11
Treatment of a large high-grade neurofibrosarcoma with concomitant vinblastine, doxorubicin, and radiotherapy. (1435843)
1992
12
von Recklinghausen's neurofibromatosis with neurofibrosarcoma. (1900842)
1991
13
Pigmented neurofibrosarcoma mimicking a large haemangioma. (1806329)
1991
14
A case of neurofibrosarcoma associated with neurofibromatosis--ganglioside analysis. (1806326)
1991
15
Chromosomes 17 and 22 involved in marker formation in neurofibrosarcoma in von Recklinghausen disease. A cytogenetic and in situ hybridization study. (2118474)
1990
16
A novel population of cells in the peripheral blood of a cow with a neurofibrosarcoma. (2251765)
1990
17
Pigmented neurofibrosarcoma mimicking a large haemangioma. (2279344)
1990
18
A case of neurofibrosarcoma associated with neurofibromatosis: light microscopic, ultrastructural, immunohistochemical and biochemical investigations. (2116469)
1990
19
Neurofibrosarcoma complicating pregnancy. (2502488)
1989
20
Malignant schwannoma (neurofibrosarcoma) metastatic to spine. Surgical decompression and stabilization. (2727803)
1989
21
Neurofibrosarcoma [corrected] as a complication of NF-1. (3152467)
1988
22
Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis. (3100319)
1987
23
Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue. (3103455)
1987
24
Sacral neurofibrosarcoma--a case report. (3729850)
1986
25
Neurofibrosarcoma in a 19-year-old cat. (6612976)
1983
26
Neurofibrosarcoma of the vagus nerve. (6844194)
1983
27
Neurofibrosarcoma and irradiation. (6288200)
1982
28
CT demonstration of a neurofibrosarcoma causing femoral neuropathy. (6815243)
1982
29
Neurofibrosarcoma of the cauda equina. Case report. (7463146)
1981
30
Morphological studies in malignant tumors of the peripheral nervous system (neurofibrosarcoma, malignant schwannoma, schwann cell sarcoma). (6939219)
1981
31
Neurofibrosarcoma of the duodenum in von Recklinghausen's disease. (105775)
1979
32
Neurofibrosarcoma of the radial nerve in von Recklinghausen's disease with metastatic angiosarcoma. (96219)
1978
33
Anal neurofibrosarcoma treated with fast neutron irradiation. (638549)
1978
34
Neurofibrosarcoma of the mandible. (266068)
1977
35
Morphologic aspects of the neurofibrosarcoma (neurogenic sarcoma). (98330)
1977
36
Clinical-pathological conference: Case 10, part 2. Neurofibrosarcoma. (1053649)
1975
37
Hyperinsulinemic hypoglycemia associated with a neurofibrosarcoma. (1130933)
1975
38
Neurofibrosarcoma of spermatic cord. (1168964)
1975
39
Sacral neurofibrosarcoma: an angiographic evaluation. Case report. (4826602)
1974
40
Neurogenic sarcoma (neurofibrosarcoma) of the tongue. (4742987)
1973
41
Neurofibrosarcoma of the orbit (malignant change in a plexiform neurofibromatosis). (4199807)
1972
42
Neurofibrosarcoma of sciatic nerve. (5508532)
1970
43
Hydromyelia in Von Recklinghausen's disease with neurofibrosarcoma. (4976961)
1969
44
Massive neurofibrosarcoma of the anterior abdominal wall. (4221755)
1966
45
Neurofibrosarcoma of the stomach. (13244990)
1955
46
Neurofibrosarcoma of the vagus nerve; report of a case. (15405150)
1950
47
Neurofibrosarcoma, with invasion of right innominate vein and superior vena cava. (18892591)
1948
48
Retroperitoneal neurofibrosarcoma]. (20255856)
1947
49
Neurofibrosarcoma of the small intestine associated with von Recklinghausen's disease. (20272751)
1947
50
NEUROFIBROSARCOMA OF THE SMALL BOWEL: REPORT OF TWO CASES. (17857318)
1939

Variations for Neurofibrosarcoma

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Expression for genes affiliated with Neurofibrosarcoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurofibrosarcoma

Search GEO for disease gene expression data for Neurofibrosarcoma.

Pathways for genes affiliated with Neurofibrosarcoma

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51PathCards, 31KEGG, 54QIAGEN, 39NCBI BioSystems Database
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Pathways related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NF2, TP73
29.4NF1, NF2
3
Show member pathways
Signaling Pathways in Glioblastoma39
9.3NF1, INSRR

Compounds for genes affiliated with Neurofibrosarcoma

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46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 3BitterDB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gemcitabine46 52 1211.2TP73, DCK
2guanosine46 25 1211.2DCK, NF1
3azathioprine46 3 52 1212.2TP73, DCK
4vincristine46 52 1211.1DCK, TP73
55-aza-2deoxycytidine469.1TP73, DCK
6cytochalasin d46 6210.1NF1, NF2
7paraffin469.1TP73, NF2, NF1
8camptothecin46 62 1211.0DCK, TP73
9progesterone46 30 62 25 1213.0NF2, NF1, TP73
10tyrosine467.8NF1, NF2, DCK, TP73, INSRR

GO Terms for genes affiliated with Neurofibrosarcoma

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17Gene Ontology
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Cellular components related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:0056347.6MXI1, NF1, NF2, DCK, TP73

Biological processes related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-matrix adhesionGO:0019539.5NF1, NF2
2negative regulation of MAPK cascadeGO:0434099.4NF1, NF2
3actin cytoskeleton organizationGO:0300369.4NF1, NF2
4negative regulation of protein kinase activityGO:0064699.3NF2, NF1
5negative regulation of cell migrationGO:0303369.1NF1, NF2

Products for genes affiliated with Neurofibrosarcoma

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Sources for Neurofibrosarcoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet