MCID: NRF003
MIFTS: 42

Neurofibrosarcoma malady

Neuronal, Cancer categories

Summaries for Neurofibrosarcoma

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64Wikipedia, 33MalaCards
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Wikipedia:64 A malignant peripheral nerve sheath tumor (MPNST) (also known as \"Malignant schwannoma,\"... more...

MalaCards: Neurofibrosarcoma, also known as malignant peripheral nerve sheath tumor, is related to neurofibromatosis and gastrointestinal stromal tumor. An important gene associated with Neurofibrosarcoma is MXI1 (MAX interactor 1, dimerization protein), and among its related pathways is Glioblastoma Multiforme. The compounds azathioprine and guanosine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, small intestine and liver, and related mouse phenotypes are hearing/vestibular/ear and tumorigenesis.

Aliases & Classifications for Neurofibrosarcoma

Sources:
8Disease Ontology, 9diseasecard, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Aliases & Descriptions:

neurofibrosarcoma 8 9 43 47 10 45
malignant peripheral nerve sheath tumor 61
neurosarcoma 8


External Ids:

Disease Ontology8 DOID:3512
SNOMED-CT57 404037002, 19897006
MeSH35 D018319

Related Diseases for Neurofibrosarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Neurofibrosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 85)
idRelated DiseaseScoreTop Affiliating Genes
1neurofibromatosis30.9NF2, NF1
2gastrointestinal stromal tumor30.7NF1, NF2
3adenocarcinoma30.4DCK, NF2, MXI1, TP73
4plexiform neurofibroma30.1TP73, NF1
5epithelioid malignant peripheral nerve sheath tumor11.0
6malignant triton tumor10.8
7benign peripheral nerve sheath tumor10.8
8synovial sarcoma10.7
9ganglioneuroma10.7
10malignant perineurioma10.7
11small cell sarcoma10.5
12malignant mesenchymal tumor10.5
13benign schwannoma10.5
14malignant cardiac peripheral nerve sheath neoplasm10.3
15malignant oculomotor nerve tumor10.3
16malignant peritoneal mesothelioma10.3
17malignant spindle cell melanoma10.3
18papillary carcinoma10.3
19cellular schwannoma10.3
20plexiform schwannoma10.3
21smooth muscle tumor10.3
22malignant epithelial mesothelioma10.3
23cervix melanoma10.3
24meningocele10.3
25intussusception10.3
26aortic malignant tumor10.3
27monophasic synovial sarcoma10.3
28fibrous synovial sarcoma10.3
29malignant glandular tumor of peripheral nerve sheath10.3
30melanocytic psammomatous mpnst10.3
31askin's tumor10.3
32mediastinum neurofibroma10.3
33horner's syndrome10.3
34bladder carcinoma10.3
35bladder disease10.3
36t cell deficiency10.3
37giant congenital nevus10.3
38carotid body tumor10.3
39desmoplastic small round cell tumor10.3
40heart tumor10.3
41neural crest tumor10.3
42cutaneous malignant melanoma10.3
43hemorrhage, intracerebral10.3
44venous thrombosis10.3
4517q11.2 microduplication syndrome10.3
46solitary fibrous tumor10.3
47hypoglycemia10.1
48soft tissue sarcoma10.1
49pancreatic cancer10.0DCK
50medulloblastoma10.0TP73

Graphical network of the top 20 diseases related to Neurofibrosarcoma:



Diseases related to neurofibrosarcoma

Clinical Features for Neurofibrosarcoma

Drugs & Therapeutics for Neurofibrosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Neurofibrosarcoma

Drug clinical trials:

Search ClinicalTrials for Neurofibrosarcoma

Search NIH Clinical Center for Neurofibrosarcoma

Search CenterWatch for Neurofibrosarcoma

Genetic Tests for Neurofibrosarcoma

Anatomical Context for Neurofibrosarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Neurofibrosarcoma:

33
Spinal cord, Small intestine, Liver, Breast, Skin, Ovary, Prostate, Tongue

Animal Models for Neurofibrosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Neurofibrosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.1TP73, NF1, NF2
2MP:00020068.8TP73, MXI1, NF1, NF2
3MP:00053678.7NF2, NF1, INSRR, MXI1
4MP:00053798.4TP73, MXI1, NF1, NF2
5MP:00053878.0DCK, NF2, NF1, MXI1, TP73

Publications for Neurofibrosarcoma

Sources:
51PubMed
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Articles related to Neurofibrosarcoma:

(show top 50)    (show all 122)
idTitleAuthorsYear
1
Molecular characteristics and pathogenicity of an avian leukosis virus isolated from avian neurofibrosarcoma. (22545526)
2012
2
Endocervical fibroblastic malignant peripheral nerve sheath tumor (neurofibrosarcoma): report of a novel entity possibly related to endocervical CD34 fibrocytes. (21317712)
2011
3
Neurofibrosarcoma - complicating neurofibromatosis-I: case report and review of relevant literature. (16160727)
2005
4
Total sacrectomy and reconstruction with structural allografts for neurofibrosarcoma of the sacrum. A case report. (15805218)
2005
5
Retroperitoneal neurofibrosarcoma in a patient with neurofibromatosis. 2: A case report and review of the literature. (14692188)
2003
6
Malignant spinal neurofibrosarcoma. (10752112)
2000
7
Cerebral air emboli in a child with neurofibrosarcoma. (10227545)
1999
8
Orbital neurofibrosarcoma in a dog. (11397256)
1999
9
Case report: isolated neurofibrosarcoma of the liver: US, CT and MR findings. (9112953)
1997
10
Bone scans in neurofibromatosis: neurofibroma, plexiform neuroma and neurofibrosarcoma. (8917174)
1996
11
Paraneoplastic opsoclonus-myoclonus syndrome and neurofibrosarcoma. (8864716)
1996
12
Clonal karyotypic evolution in a pediatric neurofibrosarcoma. (7621409)
1995
13
Orbital neurofibrosarcoma: a case report. (8919474)
1995
14
Neurofibrosarcoma of the intrathoracic vagus nerve. Case report. (8211005)
1993
15
Involvement of 22q12 in a neurofibrosarcoma in neurofibromatosis type 1. (8467471)
1993
16
Treatment of a large high-grade neurofibrosarcoma with concomitant vinblastine, doxorubicin, and radiotherapy. (1435843)
1992
17
von Recklinghausen's neurofibromatosis with neurofibrosarcoma. (1900842)
1991
18
Oral neurofibrosarcoma associated with neurofibromatosis type I. (1923446)
1991
19
Bronchial neurofibrosarcoma. (1929641)
1991
20
Immunohistochemical localization of type I, III, IV, V, and VI collagens and laminin in neurofibroma and neurofibrosarcoma. (1928621)
1991
21
A novel population of cells in the peripheral blood of a cow with a neurofibrosarcoma. (2251765)
1990
22
Neurofibrosarcoma of skin and subcutaneous tissues. (1689440)
1990
23
Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis. (3100319)
1987
24
Immunoreactivity for Leu-7 in neurofibrosarcoma and other spindle cell sarcomas of soft tissue. (3103455)
1987
25
Rectus abdominis myocutaneous free-flap reconstruction following a cranio-orbital-maxillary resection for neurofibrosarcoma. (2959974)
1987
26
Rapidly progressive neurofibrosarcoma. (6723630)
1984
27
Neurofibrosarcoma and the sign of Leser-TrAclat. (6432241)
1984
28
Neurofibrosarcoma in a 19-year-old cat. (6612976)
1983
29
Neurofibrosarcoma of the vagus nerve. (6844194)
1983
30
CT demonstration of a neurofibrosarcoma causing femoral neuropathy. (6815243)
1982
31
Morphologic aspects of the neurofibrosarcoma (neurogenic sarcoma). (98330)
1977
32
Clinical-pathological conference: Case 10, part 2. Neurofibrosarcoma. (1053649)
1975
33
Hyperinsulinemic hypoglycemia associated with a neurofibrosarcoma. (1130933)
1975
34
Neurofibrosarcoma of the hypoglossal nerve. (1176827)
1975
35
Sacral neurofibrosarcoma: an angiographic evaluation. Case report. (4826602)
1974
36
Neurofibrosarcoma of the orbit (malignant change in a plexiform neurofibromatosis). (4199807)
1972
37
Neurofibrosarcoma of sciatic nerve. (5508532)
1970
38
Hydromyelia in Von Recklinghausen's disease with neurofibrosarcoma. (4976961)
1969
39
Establishment and characterization of a feline neurofibrosarcoma (FNFS) cell line. (5813750)
1969
40
Neurofibrosarcoma. (6078229)
1967
41
TRIGEMINAL NEUROFIBROSARCOMA: REPORT OF CASE. (14075488)
1963
42
Retroperitoneal pelvic neurofibrosarcoma. (13808579)
1960
43
Mediastinal neurofibrosarcoma causing hypoglycemia. (14439307)
1959
44
Digital neurofibrosarcoma in infancy. (13476342)
1957
45
Neurofibrosarcoma; report of a case in a seven-year-old girl. (13361526)
1956
46
Presacral neurofibrosarcoma. (13092362)
1953
47
Neurofibrosarcoma of the vagus nerve; report of a case. (15405150)
1950
48
Neurofibrosarcoma of the anterior mediastinum; surgical removal. (15437582)
1950
49
Neurofibrosarcoma of the neck; report of case with ten year survival after roentgen therapy. (14771327)
1950
50
Primary neurofibrosarcoma of the diaphragm; report of two cases. (14785027)
1950

Genetic Variations for Neurofibrosarcoma

Expression for genes affiliated with Neurofibrosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Neurofibrosarcoma

Search GEO for disease gene expression data for Neurofibrosarcoma.

Pathways for genes affiliated with Neurofibrosarcoma

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52QIAGEN
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Pathways related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NF1, NF2

Compounds for genes affiliated with Neurofibrosarcoma

Sources:
45Novoseek, 50PharmGKB, 2BitterDB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
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Compounds related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1azathioprine45 50 2 1112.4TP73, DCK
2guanosine45 11 2411.3DCK, NF1
3gemcitabine45 50 1111.3TP73, DCK
4paraffin459.2TP73, NF1, NF2
5progesterone45 60 29 11 2412.8TP73, NF1, NF2
6tyrosine458.1TP73, INSRR, NF1, NF2, DCK

GO Terms for genes affiliated with Neurofibrosarcoma

Sources:
16Gene Ontology
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Biological processes related to Neurofibrosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of cell-matrix adhesionGO:0019539.5NF1, NF2
2negative regulation of cell migrationGO:0303369.5NF1, NF2
3negative regulation of MAPK cascadeGO:0434099.4NF1, NF2
4negative regulation of protein kinase activityGO:0064699.2NF1, NF2

Products for genes affiliated with Neurofibrosarcoma

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Sources for Neurofibrosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet