Neurofibrosarcoma malady

Wikipedia: A malignant peripheral nerve sheath tumor (also known as \"Malignant schwannoma,\"...⁴⁴ more...

MalaCards: Neurofibrosarcoma, also known as malignant peripheral nerve sheath tumor, is related to neurofibromatosis and cellular schwannoma. An important gene associated with Neurofibrosarcoma is NF2 (neurofibromin 2 (merlin)). The compounds guanosine and paraffin have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and renal/urinary system.

Aliases & Descriptions:

neurofibrosarcoma 6 7 30 33 8 32 43 malignant peripheral nerve sheath tumor 43

neurosarcoma 6

Diseases related to neurofibrosarcoma by text searches and GeneDecks gene sharing:

(show all 44)

id	Related Disease	Score	Top Affiliating Genes
1	neurofibromatosis	35.7	NF2, NF1
2	cellular schwannoma	31.6	NF2, NF1
3	plexiform neurofibroma	31.6	NF1, NF2
4	melanoma	30.5	MXI1, TP73, NF1, NF2, PRNT
5	neuroblastoma	28.0	DCK, NF2, NF1, TP73, INSRR, MXI1
6	malignant peripheral nerve sheath tumor	27.5	NF1, NF2
7	neurofibroma	27.5	TP73, NF1, NF2
8	nervous system cancer	13.1	NF2, NF1
9	acoustic neuroma	13.1	NF2, NF1
10	blue rubber bleb nevus syndrome	12.9	MXI1, NF1
11	neurilemmoma	12.9	NF1, NF2
12	brain cancer	12.9	TP73, NF1
13	neuroma	12.8	NF2, NF1
14	benign tumors	12.6	TP73, NF1, NF2
15	ependymoma	12.6	TP73, NF1, NF2
16	fibromatosis	12.6	NF1, NF2
17	gastrointestinal stromal tumor	12.6	TP73, NF1, NF2
18	boomerang dysplasia	12.5	NF2, NF1, TP73
19	malignant glioma	12.4	NF2, NF1, TP73
20	pilocytic astrocytoma	12.3	TP73, NF1
21	medulloblastoma	12.3	NF1, TP73, MXI1
22	astrocytoma	11.7	DCK, NF2, NF1, TP73
23	myeloid leukemia	11.4	MXI1, TP73, NF1, DCK
24	glioblastoma	11.3	DCK, NF2, NF1, TP73, MXI1
25	pancreatic cancer	11.2	DCK, NF2, NF1, TP73, MXI1
26	hepatocellular carcinoma	11.1	DCK, NF2, NF1, TP73, MXI1
27	adenocarcinoma	11.1	DCK, NF2, NF1, TP73, MXI1
28	pancreatitis	10.9	MXI1, TP73, NF1, NF2, DCK
29	epithelioid malignant peripheral nerve sheath tumor	10.5
30	sarcoma	10.5
31	synovial sarcoma	10.3
32	malignant triton tumor	9.4
33	rhabdomyosarcoma	8.0
34	soft tissue sarcoma	8.0
35	angiosarcoma	8.0
36	askin's tumor	8.0
37	malignant glandular tumor of peripheral nerve sheath	8.0
38	malignant melanocytic neoplasm of the peripheral nerve sheath	8.0
39	melanocytic psammomatous mpnst	8.0
40	monophasic synovial sarcoma	8.0
41	neuropathy	8.0
42	ovarian cancer	5.7
43	adult malignant schwannoma	5.7
44	childhood malignant schwannoma	5.7

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to neurofibrosarcoma:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	tumorigenesis	MP:0002006	8.3	MXI1, TP73, NF1, NF2
2	renal/urinary system phenotype	MP:0005367	7.9	NF2, NF1, INSRR, MXI1
3	immune system phenotype	MP:0005387	7.9	MXI1, TP73, NF1, NF2, DCK

Articles related to neurofibrosarcoma:

id	Title	Authors	Year	Affiliating Genes
1	Retroperitoneal neurofibrosarcoma in a patient with n eurofibromatosis. 2: A case report and review of the literature. (14692188)	Chen Y.... Valderrama E.	2003	NF1, NF2
2	A study of the influence of newly synthesized acyclonucleosides and 1,2,3,4-tetrahydroisoquinoline derivatives on deoxythymidine and deoxycytidine kinase activities in human neurofibrosarcoma and ovarian cancer. (14740004)	Modrzejewska H.... Greger J.	2003	DCK
3	Aberrant CpG island methylation in neurofibromas and neurofibrosarcomas. (12883734)	Gonzalez-Gomez P.... Rey J.A.	2003	TP73
4	Mxi1 mutations in human neurofibrosarcomas. (10470286)	Li X.J.... Sugimura H.	1999	MXI1

Genes related to neurofibrosarcoma according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	NF2	neurofibromin 2 (merlin)	11.0	Publications
2	TP73	tumor protein p73	11.0	Publications
3	NF1	neurofibromin 1	11.0	Publications
4	PRNT	prion protein (testis specific)	11.0
5	INSRR	insulin receptor-related receptor	11.0
6	MXI1	MAX interactor 1	11.0	Publications
7	DCK	deoxycytidine kinase	11.0	Publications

Compounds related to neurofibrosarcoma according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	guanosine32 9 18 9	12.5	NF1, DCK
2	paraffin32	8.9	NF2, NF1, TP73
3	tyrosine32	8.0	INSRR, TP73, NF1, NF2, DCK

Biological processes related to neurofibrosarcoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell-matrix adhesion	GO:001953	9.6	NF1, NF2
2	negative regulation of cell migration	GO:030336	9.6	NF1, NF2
3	negative regulation of MAPK cascade	GO:043409	9.5	NF1, NF2
4	negative regulation of protein kinase activity	GO:006469	9.3	NF1, NF2