MCID: NRG003
MIFTS: 30

Neurogenic Arthropathy

Categories: Neuronal diseases, Bone diseases

Aliases & Classifications for Neurogenic Arthropathy

MalaCards integrated aliases for Neurogenic Arthropathy:

Name: Neurogenic Arthropathy 12 14 69
Arthropathy Associated with Neurological Disorder 12
Neuropathic Arthropathy 12
Arthropathy, Neurogenic 41
Charcot's Arthropathy 12
Charcot's Joint 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14286
ICD10 32 M14.6
ICD9CM 34 713.5
MeSH 41 D001177
UMLS 69 C0003892

Summaries for Neurogenic Arthropathy

MalaCards based summary : Neurogenic Arthropathy, also known as arthropathy associated with neurological disorder, is related to mitochondrial dna depletion syndrome 6 and mpv17-related hepatocerebral mitochondrial dna depletion syndrome, and has symptoms including metatarsalgia and arthralgia. An important gene associated with Neurogenic Arthropathy is SLCO2A1 (Solute Carrier Organic Anion Transporter Family Member 2A1), and among its related pathways/superpathways is Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Hyaluronic acid and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Neurogenic Arthropathy

Diseases related to Neurogenic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 mitochondrial dna depletion syndrome 6 11.2
2 mpv17-related hepatocerebral mitochondrial dna depletion syndrome 11.2
3 arthropathy 10.4
4 ovary sarcoma 10.1 CD34 HBA1
5 ovarian angiosarcoma 10.1 CD34 HBA1
6 intravascular fasciitis 10.1 CD34 HBA1
7 pediatric angiosarcoma 10.0 CD34 HBA1
8 thyroid angiosarcoma 10.0 CD34 HBA1
9 spleen angiosarcoma 10.0 CD34 HBA1
10 bone epithelioid hemangioma 10.0 CD34 HBA1
11 thyroid sarcoma 10.0 CD34 HBA1
12 hobnail hemangioma 10.0 CD34 HBA1
13 hemangioma of liver 10.0 CD34 HBA1
14 extraosseous osteosarcoma 10.0 CD34 HBA1
15 spleen cancer 10.0 CD34 HBA1
16 breast angiosarcoma 10.0 CD34 HBA1
17 conventional angiosarcoma 10.0 CD34 HBA1
18 venous hemangioma 10.0 CD34 HBA1
19 mixed liposarcoma 10.0 CD34 HBA1
20 interstitial emphysema 10.0 CD34 HBA1
21 angiomyoma 10.0 CD34 HBA1
22 chorioangioma 10.0 CD34 HBA1
23 spindle cell liposarcoma 10.0 CD34 HBA1
24 mesenchymal cell neoplasm 10.0 CD34 HBA1
25 infiltrating lipoma 10.0 CD34 HBA1
26 integumentary system benign neoplasm 10.0 CD34 HBA1
27 lymphangiosarcoma 10.0 CD34 HBA1
28 hemangioma of intra-abdominal structure 10.0 CD34 HBA1
29 congenital epulis 10.0 CD34 HBA1
30 liver angiosarcoma 9.9 CD34 HBA1
31 cardiovascular organ benign neoplasm 9.9 CD34 HBA1
32 benign perivascular tumor 9.9 CD34 HBA1
33 nephrogenic adenofibroma 9.9 CD34 HBA1
34 diabetes mellitus 9.9
35 neuropathy 9.9
36 glomangioma 9.9 CD34 HBA1
37 connective tissue cancer 9.9 CD34 HBA1
38 type 1 diabetes mellitus 7 9.8 HBA1 INS
39 type 1 diabetes mellitus 11 9.8 HBA1 INS
40 diabetic neuropathy 9.8
41 myeloma, multiple 9.7 CD34 MYOM2
42 cell type cancer 9.7 CD34 HBA1
43 cell type benign neoplasm 9.7 CD34 INS
44 glomeruloid hemangioma 9.7 CD34 HBA1 MYOM2
45 peripheral nervous system disease 9.7 INS MYOM2
46 retinal vascular disease 9.6 HBA1 INS
47 myelofibrosis 9.6 CD34 SLCO2A1
48 glucose metabolism disease 9.6 HBA1 INS
49 meninges hemangiopericytoma 9.4 CD34 HBA1 INS

Comorbidity relations with Neurogenic Arthropathy via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Heart Disease Hypertension, Essential
Microvascular Complications of Diabetes 1 Peripheral Vascular Disease
Tabes Dorsalis

Graphical network of the top 20 diseases related to Neurogenic Arthropathy:



Diseases related to Neurogenic Arthropathy

Symptoms & Phenotypes for Neurogenic Arthropathy

UMLS symptoms related to Neurogenic Arthropathy:


metatarsalgia, arthralgia

Drugs & Therapeutics for Neurogenic Arthropathy

Drugs for Neurogenic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
2 Adjuvants, Immunologic Phase 4
3 Protective Agents Phase 4,Phase 2,Phase 3
4 Viscosupplements Phase 4
5
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
7
Zoledronic acid Approved Phase 2, Phase 3 118072-93-8 68740
8 Antiemetics Phase 2, Phase 3
9 Anti-Inflammatory Agents Phase 2, Phase 3
10 Antineoplastic Agents, Hormonal Phase 2, Phase 3
11 Autonomic Agents Phase 2, Phase 3
12 Bone Density Conservation Agents Phase 2, Phase 3
13 Diphosphonates Phase 2, Phase 3
14 Gastrointestinal Agents Phase 2, Phase 3
15 glucocorticoids Phase 2, Phase 3
16 Hormone Antagonists Phase 2, Phase 3
17 Hormones Phase 2, Phase 3
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
19 Methylprednisolone acetate Phase 2, Phase 3
20 Methylprednisolone Hemisuccinate Phase 2, Phase 3
21 Neuroprotective Agents Phase 2, Phase 3
22 Peripheral Nervous System Agents Phase 2, Phase 3
23 Prednisolone acetate Phase 2, Phase 3
24 Prednisolone hemisuccinate Phase 2, Phase 3
25 Prednisolone phosphate Phase 2, Phase 3
26
Teriparatide Approved, Investigational Phase 2 52232-67-4 16133850
27 Calcium, Dietary Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Platelet-rich Plasma vs. Hyaluronic Acid for Glenohumeral Osteoarthritis Recruiting NCT02984228 Phase 4 Hyaluronic Acid
2 Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus Recruiting NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
3 Efficacy of Teriparatide in Diabetic Inactive Charcot Neuroarthropathy of Foot Active, not recruiting NCT02023411 Phase 2 Teriparatide
4 Genetic Contribution to the Pathophysiology of the Charcot Foot in Qatari Patients With Diabetes Recruiting NCT02316483

Search NIH Clinical Center for Neurogenic Arthropathy

Cochrane evidence based reviews: arthropathy, neurogenic

Genetic Tests for Neurogenic Arthropathy

Anatomical Context for Neurogenic Arthropathy

MalaCards organs/tissues related to Neurogenic Arthropathy:

38
Bone

Publications for Neurogenic Arthropathy

Articles related to Neurogenic Arthropathy:

(show all 16)
# Title Authors Year
1
Knee Arthrodesis in Navajo Familial Neurogenic Arthropathy: A Case Report and Review of the Literature. ( 29252332 )
2013
2
Orthopaedic manifestations of Navajo familial neurogenic arthropathy. ( 20357597 )
2010
3
Neurogenic arthropathy of the knee due to chronic alcoholism: two case reports. ( 15259559 )
2003
4
The management of neurogenic arthropathy: a tale of two charcots. ( 10398548 )
1999
5
Neurogenic arthropathy. Differential diagnosis. ( 1297565 )
1992
6
Radiographic and therapeutic aspects of neurogenic arthropathy. ( 1297567 )
1992
7
Pathologic features of neurogenic arthropathy. ( 1297566 )
1992
8
Neurogenic arthropathy of the hand and wrist. ( 2428861 )
1986
9
Idiopathic neurogenic arthropathy. ( 4044822 )
1985
10
Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy. ( 6681882 )
1983
11
Marked gallium accumulation in neurogenic arthropathy. ( 6271936 )
1981
12
Neurogenic arthropathies (Charcot's joints) in children. Description of a case traced or occult spinal dysraphism. ( 1095279 )
1975
13
Neurogenic arthropathy due to diabetes mellitus. ( 5567123 )
1971
14
Neurogenic arthropathy. A critical review. ( 14405308 )
1960
15
Neurogenic arthropathy associated with diabetes mellitus; review of the literature and report of one case in a juvenile diabetic. ( 13263342 )
1955
16
Neurogenic arthropathy (Charcot joint) associated with diabetic neuropathy; report of two cases. ( 20287629 )
1947

Variations for Neurogenic Arthropathy

Expression for Neurogenic Arthropathy

Search GEO for disease gene expression data for Neurogenic Arthropathy.

Pathways for Neurogenic Arthropathy

Pathways related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.61 CD34 INS

GO Terms for Neurogenic Arthropathy

Sources for Neurogenic Arthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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