MCID: NRG003
MIFTS: 28

Neurogenic Arthropathy

Categories: Bone diseases, Neuronal diseases

Aliases & Classifications for Neurogenic Arthropathy

MalaCards integrated aliases for Neurogenic Arthropathy:

Name: Neurogenic Arthropathy 12 14 69
Arthropathy Associated with Neurological Disorder 12
Neuropathic Arthropathy 12
Arthropathy, Neurogenic 42
Charcot's Arthropathy 12
Charcot's Joint 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14286
ICD10 33 M14.6
ICD9CM 35 713.5
MeSH 42 D001177
UMLS 69 C0003892

Summaries for Neurogenic Arthropathy

MalaCards based summary : Neurogenic Arthropathy, also known as arthropathy associated with neurological disorder, is related to mpv17-related hepatocerebral mitochondrial dna depletion syndrome and mitochondrial dna depletion syndrome 6, and has symptoms including arthralgia and metatarsalgia. An important gene associated with Neurogenic Arthropathy is SLCO2A1 (Solute Carrier Organic Anion Transporter Family Member 2A1), and among its related pathways/superpathways is Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Hyaluronic acid and Adjuvants, Immunologic have been mentioned in the context of this disorder. Affiliated tissues include bone.

Related Diseases for Neurogenic Arthropathy

Diseases related to Neurogenic Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
id Related Disease Score Top Affiliating Genes
1 mpv17-related hepatocerebral mitochondrial dna depletion syndrome 11.0
2 mitochondrial dna depletion syndrome 6 11.0
3 arthropathy 10.3
4 dysgraphia 10.1 CD34 HBA1
5 ovarian lymphoma 10.1 CD34 HBA1
6 neurofibroma 10.1 CD34 HBA1
7 conventional angiosarcoma 10.1 CD34 HBA1
8 pleomorphic adenoma 10.1 CD34 HBA1
9 dermoid cyst 10.1 CD34 HBA1
10 papillary meningioma of the cerebellum 10.1 CD34 HBA1
11 cervical adenoma malignum 10.1 CD34 HBA1
12 cervical endometrial stromal sarcoma 10.1 CD34 HBA1
13 coronary aneurysm 10.1 CD34 HBA1
14 hemopneumothorax 10.1 CD34 HBA1
15 fibrillary astrocytoma 10.1 CD34 HBA1
16 thyroid angiosarcoma 10.1 CD34 HBA1
17 thyroid sarcoma 10.1 CD34 HBA1
18 uremia 10.1 CD34 HBA1
19 median neuropathy 10.1 CD34 HBA1
20 hyperlucent lung 10.1 CD34 HBA1
21 encephalitozoonosis 10.1 CD34 HBA1
22 rectosigmoid junction neoplasm 10.0 CD34 HBA1
23 cutaneous liposarcoma 10.0 CD34 HBA1
24 fibrosarcoma of bone 10.0 CD34 HBA1
25 renal adenoma 10.0 CD34 HBA1
26 mucinous intrahepatic cholangiocarcinoma 10.0 CD34 HBA1
27 connective tissue benign neoplasm 10.0 CD34 HBA1
28 tactile epilepsy 10.0 CD34 HBA1
29 mucin-rich endometrial endometrioid adenocarcinoma 10.0 CD34 HBA1
30 ossifying fibromyxoid tumor 10.0 CD34 HBA1
31 bone benign neoplasm 10.0 CD34 HBA1
32 hilar cholangiocellular carcinoma 9.9 CD34 HBA1
33 nodular tenosynovitis 9.9 CD34 HBA1
34 hyperpituitarism 9.9 CD34 HBA1
35 gestational choriocarcinoma 9.9 CD34 HBA1
36 neuropathy 9.8
37 cpt deficiency, hepatic, type ia 9.8 CD34 MYOM2
38 paroxysmal nonkinesigenic dyskinesia 2 9.8 HBA1 INS
39 neuropathy, hereditary sensory and autonomic, type ic 9.8 HBA1 INS
40 diabetic neuropathy 9.7
41 salivary gland adenoid cystic carcinoma 9.6 CD34 HBA1 MYOM2
42 male reproductive organ benign neoplasm 9.6 CD34 INS
43 vernal conjunctivitis 9.5 HBA1 INS
44 pancreatic acinar cell adenocarcinoma 9.5 INS MYOM2
45 pericardial tuberculosis 9.3 CD34 HBA1 INS
46 hypertrichosis 9.3 HBA1 INS
47 survival motor neuron spinal muscular atrophy 9.1 HBA1 INS
48 vulvar dystrophy 8.3 CD34 HBA1 INS MYOM2 SLCO2A1

Comorbidity relations with Neurogenic Arthropathy via Phenotypic Disease Network (PDN):


Acute Cystitis Decubitus Ulcer
Deficiency Anemia Diabetic Polyneuropathy
Heart Disease Hypertension, Essential
Microvascular Complications of Diabetes 1 Peripheral Vascular Disease
Tabes Dorsalis

Graphical network of the top 20 diseases related to Neurogenic Arthropathy:



Diseases related to Neurogenic Arthropathy

Symptoms & Phenotypes for Neurogenic Arthropathy

UMLS symptoms related to Neurogenic Arthropathy:


arthralgia, metatarsalgia

Drugs & Therapeutics for Neurogenic Arthropathy

Drugs for Neurogenic Arthropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
2 Adjuvants, Immunologic Phase 4
3 Protective Agents Phase 4,Phase 2,Phase 3
4 Viscosupplements Phase 4
5
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
7
Zoledronic acid Approved Phase 2, Phase 3 118072-93-8 68740
8 Antiemetics Phase 2, Phase 3
9 Anti-Inflammatory Agents Phase 2, Phase 3
10 Antineoplastic Agents, Hormonal Phase 2, Phase 3
11 Autonomic Agents Phase 2, Phase 3
12 Bone Density Conservation Agents Phase 2, Phase 3
13 Diphosphonates Phase 2, Phase 3
14 Gastrointestinal Agents Phase 2, Phase 3
15 glucocorticoids Phase 2, Phase 3
16 Hormone Antagonists Phase 2, Phase 3
17 Hormones Phase 2, Phase 3
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
19 Methylprednisolone acetate Phase 2, Phase 3
20 Methylprednisolone Hemisuccinate Phase 2, Phase 3
21 Neuroprotective Agents Phase 2, Phase 3
22 Peripheral Nervous System Agents Phase 2, Phase 3
23 Prednisolone acetate Phase 2, Phase 3
24 Prednisolone hemisuccinate Phase 2, Phase 3
25 Prednisolone phosphate Phase 2, Phase 3
26
Teriparatide Approved, Investigational Phase 2 52232-67-4 16133850
27 Calcium, Dietary Phase 2
28 Antirheumatic Agents Phase 1, Phase 2
29 Interleukin 1 Receptor Antagonist Protein Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumentated Posterolateral Fusionin The IVANOS-study Completed NCT02895555 Phase 4
2 Platelet-rich Plasma vs. Hyaluronic Acid for Glenohumeral Osteoarthritis Recruiting NCT02984228 Phase 4 Hyaluronic Acid
3 Zoledronic Acid or Methylprednisolone for Active Charcot's Neuroarthropathy of Foot in Patients With Diabetes Mellitus Recruiting NCT03289338 Phase 2, Phase 3 Zoledronic Acid;Methylprednisolone;Placebos
4 The Clinical Effect of i-FACTOR® Versus Allograft in Non-instrumented Posterolateral Spondylodesis Operation in the Elderly With Spinal Stenosis Due to Degenerative Spondylolisthesis Active, not recruiting NCT01618435 Phase 3
5 Efficacy of Teriparatide in Diabetic Inactive Charcot Neuroarthropathy of Foot Active, not recruiting NCT02023411 Phase 2 Teriparatide
6 Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease Terminated NCT00069329 Phase 1, Phase 2 anakinra
7 The Use of PET/CT to Evaluate Synovitis in the Temporomandibular Joint (TMJ) Withdrawn NCT01471418 Phase 2 PET/CT with 18-FDG
8 Characterization of Local and Systemic Bone Markers in Diabetes Patients With Charcot Osteoarthropathy Unknown status NCT02386579
9 Neurogenic Inflammation in Diabetes Completed NCT01370837
10 Genetic Contribution to the Pathophysiology of the Charcot Foot in Qatari Patients With Diabetes Recruiting NCT02316483

Search NIH Clinical Center for Neurogenic Arthropathy

Cochrane evidence based reviews: arthropathy, neurogenic

Genetic Tests for Neurogenic Arthropathy

Anatomical Context for Neurogenic Arthropathy

MalaCards organs/tissues related to Neurogenic Arthropathy:

39
Bone

Publications for Neurogenic Arthropathy

Articles related to Neurogenic Arthropathy:

(show all 15)
id Title Authors Year
1
Orthopaedic manifestations of Navajo familial neurogenic arthropathy. ( 20357597 )
2010
2
Neurogenic arthropathy of the knee due to chronic alcoholism: two case reports. ( 15259559 )
2003
3
The management of neurogenic arthropathy: a tale of two charcots. ( 10398548 )
1999
4
Pathologic features of neurogenic arthropathy. ( 1297566 )
1992
5
Radiographic and therapeutic aspects of neurogenic arthropathy. ( 1297567 )
1992
6
Neurogenic arthropathy. Differential diagnosis. ( 1297565 )
1992
7
Neurogenic arthropathy of the hand and wrist. ( 2428861 )
1986
8
Idiopathic neurogenic arthropathy. ( 4044822 )
1985
9
Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy. ( 6681882 )
1983
10
Marked gallium accumulation in neurogenic arthropathy. ( 6271936 )
1981
11
Neurogenic arthropathies (Charcot's joints) in children. Description of a case traced or occult spinal dysraphism. ( 1095279 )
1975
12
Neurogenic arthropathy due to diabetes mellitus. ( 5567123 )
1971
13
Neurogenic arthropathy. A critical review. ( 14405308 )
1960
14
Neurogenic arthropathy associated with diabetes mellitus; review of the literature and report of one case in a juvenile diabetic. ( 13263342 )
1955
15
Neurogenic arthropathy (Charcot joint) associated with diabetic neuropathy; report of two cases. ( 20287629 )
1947

Variations for Neurogenic Arthropathy

Expression for Neurogenic Arthropathy

Search GEO for disease gene expression data for Neurogenic Arthropathy.

Pathways for Neurogenic Arthropathy

Pathways related to Neurogenic Arthropathy according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.61 CD34 INS

GO Terms for Neurogenic Arthropathy

Sources for Neurogenic Arthropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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